Gene NvecPTP-sf2-5 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily NvecPTP-sf2
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP048_AA protein Get Run
NvecP048_AA_316-591 phosphatase_domain Get Run
NvecP048_AA_603-884 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 311-772 6.6e-229 756.2 In-house 2-462 (564) alignment 
Range on Protein: 311-772
Range on HMM: 2-462/564.0
SKPISVAHFPKYVAIMQANRGIRLEAEYKNVSNEQQFSWDAARKAANKKKNRYGNIVTYDHSRVVLERVNGDEDSDYINASFIHGFDgTPRSYIASQGPP
||||.||.....|| ..||.....| |||.....|||.|.||.| |||.|||| ||| ||||||||..|.|||.|||||||||.|.. ....|||.||| 
skpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPl

PPTFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPEK-TETYGGVTVTLHQTEVFADYVIRTFILFREERAVRRMVRQFNFTVWPDKGVPQYATAVL
..|.| ||||||||||..|||||.|.| ||.||||||||| |||||..||||...| .|||.||||.| ....   |.||||.|| |||.|||..||..|
aetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslL

AFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENFNQTTQKL
...|||||||..||||..|||||||||||..||||||||..| ..||||..|..||||.|..||||.|||.|||.|.||||.|||||..|||..|..|||
dlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkL

ASVNRKFQMTGYALEFQRLNsfTSREIPAEEKSVGEEPQNLQKNRFCDIVALNSCRVMLRKEHADEESDYINAVFLHAHRERNAFIATQHPLLETVEDFW
|.|.....|||..||||||.  |..||..||..|...|.|..|||| .|.||.||||.|....|.||||||||..|.|.||..||||||.|| .||||||
aeveedtemtgleleFqrLa..takeieleefavatkpknkkknrfsnilalescrvvlsairakeesdyinasyleayrekrafiatqaplkntvedfw

RMVTDYDIGTIVMLNNLHE-LDQEYPQYWPDHGATKYGHIGVSVLSKQEKGDVISTKLEVTRKK
|||.......||||..|.| |..|. .|..|..|||||.|...||.|.||.|.. .| .|..|.
rmvweeevkiivmltkleekleeesseyysdleatkyGeitikvlkkkeksdilfrkkkvevke
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 593-890 9.4e-146 479.7 In-house 1-297 (298) alignment 
Range on Protein: 593-890
Range on HMM: 1-297/298.0
GNTEIQSENFNQTTQKLASVNRKFQMTGYALEFQRLNSFTSrEIPAEEKSVGEEPQNLQKNRFCDIVALNSCRVMLRKEHADEESDYINAVFLHAHRERN
|||||..|......||||.|..|...|||||||||||| .| ||..|||.|...|.| .|||..||.||.|.||.|.||.||||||||||.||||...||
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvss.eieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn

AFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ-EYPQYWPDHGATKYGHIGVSVLSKQEKGDVISTKLEVTRKKVRrKTHEVRHLHHVSWPDK
||||||.|| |||||||||||..||||||||.||.|||. .|..||||.|...||.| ||.|||.|..|.|..||.|..||.. |..|||.||..|||||
afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdk

CIPEVACSVLDLLDDVQTSQQQCGNAPVLVQCSNGVGRSGTFCVISSVIERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKYLGSFSDYA
..||.|.||||||..|..||||.||.||.||||.||||||||..|.||.||.|.|||.|||||.|..|..|||||.. .||||.|......| ||.|..
gvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 308-598 9.3e-133 437.1 In-house 3-298 (298) alignment 
Range on Protein: 308-598
Range on HMM: 3-298/298.0
DDLSKPISVAHFPKYVAIMQANRGIRLEAEYKNVSNEQQ----FSWDAARKAANKKKNRYGNIVTYDHSRVVLERVNGDEDSDYINASFIHGFDGTPrSY
.......  |...|..|...... .....|...... ..    .....||| .||||||| .|...|.||||||....||.||||||||.|...|.. ..
teieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn.af

IASQGPPPPTFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPE-KTETYGGVTVTLHQTEVFADYVIRTFILFREERAVRRMVRQFNFTVWPDKGVP
||.|.| ..|.|.|||||.|.....|||||||.||.|||.|||||. ..|||| .||.|...|.|||...|.... ..... .|.|||..||.|||||||
iatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvp

QYATAVLAFRRKVRAlNPRDAG--PVIVHCSAGVGRTGAYIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQ
..||.||...||||| ....||  ||||.|||||||.|..|.||..||..|....||.......|||.||..|||.|||.||..||||||...|.||.
enatsvldllrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndeie
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 641-891 8.4e-125 410.0 In-house 1-250 (250) alignment 
Range on Protein: 641-891
Range on HMM: 1-250/250.0
KSVGEEPQNLQKNRFCDIVALNSCRVMLRKEHADEESDYINAVFLHAHRERNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQEYPQYWPDH
|||...|||..|||. ||.||.|.||.| ||..|.|||||||.|||...||.||||||.|| .|.|||||||.....||||||.||.| ...|.||||  
ksvakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPve

GATKYGHIGVSVLSKQEKGDVISTKLEVTRKKvRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQTSQQQCGNAPVLVQCSNGVGRSGTFCVISSVI
.|.|||.. ||.|||.|..|....|| ....| . .   ||.||.|.||||..|||| .||.||..||.||||.|||||.||||.||||||.|..|..|.
kaekyGdvtvsllskeefadytkrklklskak.kaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavl

ERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKYLGSFSDYAN
||||.|.|.|||.|||..| .||.|||||.||||.|.||.|.| |..|||.
erlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedyar
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 351-599 7.9e-119 390.4 In-house 3-245 (250) alignment 
Range on Protein: 351-599
Range on HMM: 3-245/250.0
AARKAANKKKNRYGNIVTYDHSRVVLERVNGDEDSDYINASFIHGFDGTpRSYIASQGPPPPTFEGFWRMVWEQNSQSIVMLTNLVELGKTkCHKYWP-E
 |.| .||.|||| .|...|.||||||...||..||||||||.||.|.. ...||.||| ..|.|.|||||.|..|..|||||||.| .|| .|.||| |
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve

KTETYGGVTVTLHQTEVFADYVIRTFILFREERAVRRMVRQFNFTVWPDKGVPQYATAVLAFRRKVRALNPR-DAGPVIVHCSAGVGRTGAYIVIDAMLE
|.|.||.|||.|...|.||||..|...| ....| .|.|||..|.||||||||..|||||....||.| ... ...||||.|||||||.||.|.|||.||
kaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavle

QAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCgnteiqS
..|....||.......|||||||.|...|||.|.....|.||..      .
rlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds......v
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 314-628 6.5e-111 365.4 In-house 2-318 (318) alignment 
Range on Protein: 314-628
Range on HMM: 2-318/318.0
ISVAHFPKYVAIMQANRGIRLEAEYKNV-SNEQQFSWDAARKAANKKKNRYGNIVTYDHSRVVLERVNGDEDSDYINASFIHGFDgTPRSYIASQGPPPP
||| .. . |. ....  . |..||...  .|.....  . . .||.|||| ||..|||.|| |. ..|.|.||||||..| |.    ..|||.|.| | 
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyr.rkkayiaaqaPlpe

TFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPEK-TETYGGVTVTLHQTEVFADYVIRTFILFREERAVRRMVRQFNFTVWPDKGVPQYATAVLAF
|.| ||||||||||. |||||...| ||.|.|.|||.| ...|| ..|.|...  ..|||.|.| . |.|    |.|||...| |||.|||. .. .|..
tieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldl

RRKVRALN-PRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENFNQTTQKLA
 |.|.. . . .|||..||||||||||| .|..|..||..| . .||. ..   ||. |. ||||..|| ||. ..||||..|.||........  ..| 
vrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelr

SVNRKFQMTGYALEFQRL
 .. .  .|   .|||||
eqdpesgttemdaefqrl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 312-626 3.4e-106 349.9 In-house 3-319 (319) alignment 
Range on Protein: 312-626
Range on HMM: 3-319/319.0
KPISVAHFPKYVAIMQANRGIRLEAEYKNVSNEQQFSWDAARKAANKKKNRYGNIVTYDHSRVVLERVNGDEDSDYINASFIHGFDGTpRSYIASQGPPP
..| |... ... .....    || |.|.... .....| | |  ||||||| ||..||..||||  ..| |.||||||||| |..   . .|| |.|  
teievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqer.ekfiatqaPle

PTFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPEKT-ETYGGVTVTLHQTEVFADYVIRTFILFREERAV-RRMVRQFNFTVWPDKGVPQYATAVL
 |.| |||||||..|  .||||.||| .| |..|||||.. |.|| ..||| . |  .||.|| . | .    |  |.| .| .| |||..||..||..|
ntiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatsll

AFRRKVRALNPR-DAGPVIVHCSAGVGRTGAYIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENFNQTTQK
.. ...|    . ..||..|||||||||||..||.|||||. | . ..|. ..   ||  |. |||..|||.||. |.|||...|.|||. .....  ..
dllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkq

LASVNRKFQMTGYALEFQ
||. . .  .|| . |||
laekvadtgetglerefq
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 351-589 1.7e-100 330.1 In-house 1-239 (239) alignment 
Range on Protein: 351-589
Range on HMM: 1-239/239.0
AARKAANKKKNRYGNIVTYDHSRVVLERVNGDEDSDYINASFIHGFDGTPRSYIASQGPPPPTFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPEK
||.|  || |||| |||||||||||||... |  |||||||... .||.|..|||.||   ..   ||||.|..    ||||| |.|  | |||.|||. 
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

TETYGGVTVTLHQTEVFADYVIRTFILFREERAVRRMVRQFNFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQA
|  |  . |||..|||||||.||||.. .  ..  | | |. ||||||||||||||||| .|||.   .   | | ..|||||||||||..|||||| ||
tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

KINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
| ..|||| ||. |.|.|||||||| ||| ||| |||||
kkqktvdifnyvkairedrphmvqtseqyvfihlavlea
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 350-588 3.3e-100 329.2 In-house 1-239 (239) alignment 
Range on Protein: 350-588
Range on HMM: 1-239/239.0
DAARKAANKKKNRYGNIVTYDHSRVVLERVNGDEDSDYINASFIHGFDGTPRSYIASQGPPPPTFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPE
.||.|  || |||| |||||||||||||... |  |||||||... .||.|..|||.||   ..   ||||.|..    ||||| |.|  | |||.|||.
eaakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd

KTETYGGVTVTLHQTEVFADYVIRTFILFREERAVRRMVRQFNFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQ
 |  |  . |||..|||||||.||||.. .  ..  | | |. ||||||||||||||||| .|||.   .   | | ..|||||||||||..|||||| |
stskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq

AKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
|| ..|||| ||. |.|.|||||||| ||| ||| ||||
akkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_PTPRB_pd Subfamily PTPRB 311-592 4.5e-100 329.5 In-house 4-287 (293) alignment 
Range on Protein: 311-592
Range on HMM: 4-287/293.0
SKPISVAHFPKYVAIMQANRGIRLEAEYKNVSN-EQQFSWDAARKAANKKKNRYGNIVTYDHSRVVLERVNGDEDSDYINASFIHGFDgTPRSYIASQGP
||||.. .| ..|. |.|.  .|.  ||..... ... . .||..|.|..|||| ||..|||||| |. ......||||||..|.|.  .|| .||.|||
skpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgyn.sprefiatqGP

PPPTFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPEK--TETYGGVTVTLHQTEVFADYVIRTFILFReeRAVRRMVRQFNFTVWPDKGVPQYATA
 | |.. |||||||..|. |||||.||| ||.||..|||..  . .|| ..||| ..|.  |.|||.. . .  .  .| |||..|| ||| |||. ...
lpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektkt

VLAFRRKVRALN--PRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTC
.|.| |.||       ...|..|||||||||||..| .| .|.. . . .|||   ...||..| ..|||..|| |||..||. |. 
lldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk
subfamily_PTPRG_pd Subfamily PTPRG 314-606 1.9e-98 325.1 In-house 1-303 (563) alignment 
Range on Protein: 314-606
Range on HMM: 1-303/563.0
ISVAHFPKYVAIMQANRGIRLEAEYK---NVSNEQQFSWDAARKAANKKKNRYGNIVTYDHSRVVLERVNGDEDS-DYINASFIHGFDgTPRSYIASQGP
. | .| |.|| . |.  |....|..   . ......  ....|  ||.|||| |||.||.||| |. . | ... |||||..|.|.    . .||.|||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyq.kskafiatqgp

PPPTFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPE-KTETYGGVTVTLHQTEVFADYVIRTFILFR------EERAVRRMVRQFNFTVWPDKGVP
 . ||. ||||.||||.. |||.||||| |. ||. |||. ..|||| ..||| ..||.| | .||...        ...   ..|||...| |||.|||
lkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvP

QYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENF
.... || | .|  | |...|||..||||||||||| |||.|..|.| . . .|.. . |  .|  |...|||.||| |.| |.|||.. ..||...|. 
ehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqv

NQTT
..  
eelk
subfamily_PTPRK_pd Subfamily PTPRK 315-610 2.6e-98 323.7 In-house 5-297 (314) alignment 
Range on Protein: 315-610
Range on HMM: 5-297/314.0
SVAHFPKYVAIMQANRGIRLEAEYKNVSNEqqfsWDAARKAANKKKNRYGNIVTYDHSRVVLERVNGDEDSDYINASFIHGFDgTPRSYIASQGPPPPTF
 ||   . .|..... |  .  ||... .     ||||.|  |..|||.|.|..||.|||.|  ..|| .||||||..| ..   |. .|. ||| . | 
rvadllqsiallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsyk.rpaafivtqgPlqetv

EGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPEKTETYGGVTVTLHQTEVFADYVIRTFILFREERA--VRRMVRQFNFTVWPDKGVPQYATAVLAFR
. |||.|...|. ||||||.||| |. || |||||.||.|| . |.| .||. |..|.|.| . . .|.   .|.||||.|. ||| .||..||..|.. 
kdfWrlvydencasivmltelvevgrvkClkyWPedtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklv

RKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENFNQTTQKLA
|.| . .. .||...|||||| ||||..|.|| .|. .. ...||. |   .||. .. ||.|.||| ||. ..|||  ||.| |   .|. .  .  
rrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalylesi
0051299 (Phosphotyrosine protein) phosphatases II 312-590 1.6e-96 318.4 In-house 3-286 (288) alignment 
Range on Protein: 312-590
Range on HMM: 3-286/288.0
KPISVAHFPKYVAIMQANRGIRLEAEYKNVSNEQ-QFSWDAARKAANKKKNRYGNIVTYDHSRVVLERVNGDEDSDYINASFIHGFDGTPRsYIASQGPP
..||| .. |.|  ..||   .|..|.. . . . .... ||.. .|..|||| .|. ||||||.|  ..|.|.|||||||.|.|.. . . .|| ||| 
teisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk.fIatqgPl

PPTFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP-EKTETYGGVTVTLHQTEVFADYVIRTFILFRE----ERAVRRMVRQFNFTVWPDKGVPQYA
| |.| |||||||||.. |||||.|||||..||..||| ....||| .||||  .||..||..||... .          |.|..| .| ||| |||...
pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

TAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
...|.| |.||  .. . |||.|||||||||||..|..| .||| . ...||. ...  ||. ||.|||| ||| |.. |.||.|
ellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0050432 (Phosphotyrosine protein) phosphatases II 311-594 6.4e-95 313.3 In-house 23-303 (308) alignment 
Range on Protein: 311-594
Range on HMM: 23-303/308.0
SKPISVAHFPKYVaiMQANRGIRLEAEYKNVSNEQQ-FSWDAARKAANKKKNRYGNIVTYDHSRVVLervngDEDSDYINASFIHGFD-GTPRSYIASQG
|...|| .. |..  ..|.   .||.|.. . . .  .....|.. .||.|||| .|. ||||||.|     ||.|||||||...|.. . || .|| ||
slklsvldllkll..ekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqg

PPPPTFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPE----KTETYGGVTVTLHQTEVFADYVIRTFILFREERAVRRMVRQFNFTVWPDKGVPQY
| | |.| |||||||||.. |||||.||| |. ||..|||.    ....||..||||  .||..||..||..|   .    |.|..| .| ||| |||..
PlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPps

ATAVLAFRRKVRALNprDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGN
....|.| ..||  .  . ||..|||||||||||..|..| .||| . ...||. ...  ||. ||.||||.||| |.. |.|| | .  
peilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
0040438 (Phosphotyrosine protein) phosphatases II 316-601 7.5e-95 313.1 In-house 2-287 (317) alignment 
Range on Protein: 316-601
Range on HMM: 2-287/317.0
VAHFPKYVAIMQANRGIRLEAEYKNVSNEQQFSWDAARKAANKKKNRYGNIVTYDHSRVVLERVNGDEDSDYINASFIHGFDGTPRsYIASQGPPPPTFE
| ......  . ..   .|. |.... . .  ... |.. .||.|||| .|. ||||||.|  ..||.||||||||...|.. ... .|| ||| | |.|
vldlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrk.fIatqgPlpntve

GFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP-EKTETYGGVTVTLHQTEVFADYVIRTFILFREERAVRRMVRQFNFTVWPDKGVPQYATAVLAFRRK
 ||||||||....|||||.|.|||. ||..||| ..| |||..|||| ..|. |....||. .   .    |.|..| .| ||| |||.. . .|.| ..
dFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldflea

VRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSEN
||. .... |||.|||||||||||..|... |||| . ...||. . .  ||. ||..||| ||| |.. |.|| |....| .   .
vrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepase
subfamily_PTPRA_pd Subfamily PTPRA 312-624 8.3e-95 312.4 In-house 12-329 (330) alignment 
Range on Protein: 312-624
Range on HMM: 12-329/330.0
KPISVAHFPKYVAIMQANRGIRLEAEYKNVSN-EQQFSWDAARKAANKKKNRYGNIVTYDHSRVVLERVNGDEDSDYINASFIHGFDGTpRSYIASQGPP
 |. | .. . . | .|.   ..  |....   . | . ..| |  ||.|||. ||. ||.|||.|  ..| |.|||||||||.|.     ..||.||| 
fplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykek.dkfiaaqGPk

PPTFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPEK-TETYGGVTVTLHQTEVFADYVIRTFILFR----EERAVRRMVRQFNFTVWPDKGVPQYA
  | | ||||.|||.|..|||||.| |  ..||..|||.. . ||| ..|......|  || .| |.. .     ..   |.|||| || ||| |||  .
eetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfep

TAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENFNQT
  .| . .||..||.. |||..|||||||||||..||.||.||. | .| ||. . .  ||. ||.||||.||| ||. ..||    |.||..   ... 
iGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekh

TQKLASVNRKFQMTGYALE
 ||| .   ... .|   |
lqklynkitgtdkigleee
0046845 (Phosphotyrosine protein) phosphatases II 334-595 5.9e-92 303.3 In-house 2-279 (284) alignment 
Range on Protein: 334-595
Range on HMM: 2-279/284.0
LEAEYKNVSNEQQF---SWDAARKAANKKKNRYGNIVTYDHSRVVLERVNGD-EDSDYINASFIHGFD----GTPRSYIASQGPPPPTFEGFWRMVWEQN
||.|.. . . . .   |...|.. .|..|||| .|. ||||||.| ...|| |||||||||...|.|     ... .|| ||| | |.| |||||||||
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

SQSIVMLTNLVELGKTKCHKYWPEK--TETYGGVTVTLHQTEVFADYVIRTFILFREE-RAVRRMVRQFNFTVWPDKGVPQYATAVLAFRRKVRALNP--
.. |||||.||| |..||..|||..  . |||..||||  .||. ||..||. | ...     |.|..| .| ||| |||.... .|.| |.|| |..  
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

RDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKINR---TVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNT
 . ||..|||||||||||..|..| .||| . ..   .||. ...  ||. ||.|||| ||| |.. |.||.| ...|
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 312-609 1.9e-91 301.4 In-house 2-302 (305) alignment 
Range on Protein: 312-609
Range on HMM: 2-302/305.0
KPISVAHFPKYVAIMQANRGIRLEAEYKNVSNEqQFSWDAARKAANKKKNRYGNIVTYDHSRVVLERVNGDEDSDYINASFIHGFDGTpRSYIASQGPPP
|.|..... .|.  ....    |||.||.. .| . | |  .| |||.|||. .|...|..|. |   . ..||||||||...|...   .||..||| .
kiialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrk.kkyivaqgPlk

PTFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPEKTET---YGGVTVTLHQTEVFADYVIRTFILFR-EERAVRRMVRQFNFTVWPDKGVPQYATA
 | . |||...|   ..|||||.||| || ||..||||..     .| ..|.|.... ..||..| . .   .|    | | |...| |||.||||.||.
ntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfats

VLAFRRKVRALNPRDAG-PVIVHCSAGVGRTGAYIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENFNQTT
.| . ..|.    .| | |..|||||||||||..|..| .||..|   .||. ..| .||. |. ||||..|| |.| |. | .|||.|.|  .|..   
llslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarv

QKL
.||
nkl
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 312-607 3.4e-91 300.5 In-house 4-296 (315) alignment 
Range on Protein: 312-607
Range on HMM: 4-296/315.0
KPISVAHFPKYVAIMQANRGIRLEAEYKNVSNEQQFSWDAARKAANKKKNRYGNIVTYDHSRVVLERVNGDEDSDYINASFIHGFDgTPRSYIASQGPPP
.|| . ..  |||  .|.    .. .|...   | .  | |.|  ||.|||| ||..||.||| |  .. |..|||.||.|| |..  .| |||.||| .
qpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGyn.kkrryiaaqgpnv

PTFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPEKTETYGGVTVTLHQTEVFADYVIRTFILFREERaVrRMVRQFNFTVWPDKGVPQYATAVLAF
 . . |||.|.|..   |||||||||  | |. ||||.|  .|| .|||. . ||. .| .||.    ... . | | |...| ||| |||.|..... .
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviyGkitvtrkseevnteytvrtlsvvfgdn.i.revvqlhytswpdmgvpkytiplmnl

RRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENFNQTTQ
 |.|.  .  ..|...|||||||||||..| .||.|.||.... .|. |..  .|. | .|||. ||| ||..|.||.. ||.| |  . . |  .
irtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqryd
0043336 (Phosphotyrosine protein) phosphatases II 313-588 5.3e-91 300.2 In-house 1-275 (278) alignment 
Range on Protein: 313-588
Range on HMM: 1-275/278.0
PISVAHFPKYVAIMQANRGIRLEAEYKNVSNEQQFSWDAARKAANKKKNRYGNIVTYDHSRVVLERVNGDEDSDYINASFIHGFDGTPRsYIASQGPPPP
|||| ...|... . .|   .|..|.... . . .... |.. .||.|||| .|. ||||||.|. ..||.||||||||.. |.. ... .||.||| | 
pisvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprk.fiatqgPlpe

TFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPEKTETYGGVTVTLHQTEVFADYVIRTFILFREERAVRRMVRQFNFTVWPDKGVPQYATAVLAFR
|.| |||||||.....|||||.|||||..||..|||....|||..||||  .|...||..||. . .      |.|... .. ||| |||   . .| | 
tvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldfl

RKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
..||  .. . |||.|||||||||||..|... .|||.. ...||. . .  ||. ||..||| .|| |.. |.||
kavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
0039614 (Phosphotyrosine protein) phosphatases II 313-594 7e-90 296.8 In-house 13-293 (297) alignment 
Range on Protein: 313-594
Range on HMM: 13-293/297.0
PISVAHFPKYVAIMQANRGIRLEAEYKNVSNEQQfSWDAARKAANKKKNRYGNIVTYDHSRVVLERVNG-DEDSDYINASFIHGFDGTPRSYIASQGPPP
||.. ... .. ...||   .|..|.... . .  ..  |.. .||.|||| .|. ||||||.|  ..| |.||||||||.. |.| ..| .||.||| |
piplsvldlllllekansktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlp

PTFEGFWRMVWEQNSQSIVMLTNLVELGKtKCHKYWPEKTETYGGVTVTLHQTEVFADYVIRTFILFReeRAVRRMVRQFNFTVWPDKGVPQYATAVLAF
 |.| ||||||||....|||||.|||||. ||..||||...|||..|||| ..|. ..|..||. . .      |.|..| .| ||| |||.... .| |
etvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeeggtygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslelllef

RRKVRALNPR--DAGPVIVHCSAGVGRTGAYIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGN
 ..||  . .  . |||.|||||||||||..|... |||| . ...||. . .  ||. ||..||| .|| |.. |.|| | ...
lelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 356-588 1e-89 294.9 In-house 2-237 (237) alignment 
Range on Protein: 356-588
Range on HMM: 2-237/237.0
ANKKKNRYGNIVTYDHSRVVLERVNGDedSDYINASFIHGFDGTPRSYIASQGPPPPTFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPE--KTET
 || ||||||||.||||||||.   ..  ||||||....||||||..|||.|||  .. . ||.|||...   ||||| |.|  . |||||||.  . ..
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGGVTVTLHQTEVFADYVIRTFILFREE-RAVRRMVRQFNFTVWPDKGVPQYATAVLAFRRKVRALNPR--DAGPVIVHCSAGVGRTGAYIVIDAMLEQA
|| .||.|.. | |.|| .|...|...      |.. |..||.|||.||||...|.| ||...   .|   ..|| |.|||||||||| ..|||||| ||
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

KINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
| .. ||| ||. .. .|||...|||.|| ||| ..||
kekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
0036941 (Phosphotyrosine protein) phosphatases II 342-597 2.8e-89 294.6 In-house 24-284 (297) alignment 
Range on Protein: 342-597
Range on HMM: 24-284/297.0
SNEQQFSWDAARKAANKKKNRYGNIVTYDHSRVVLervnGDEDSDYINASFIHGFdGTPRSYIASQGPPPPTFEGFWRMVWEQNSQSIVMLTNLVELGKT
..  ..|...|.. .|..|||| .|. |||.||.|    .||.|||||||.. |. . .| .|| ||| | |.| |||||||||...|||||.|||||. 
pllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgy.dlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgre

KCHKYWP---EKTETYGGVTVTLHQTEV--FADYVIRTFILFREERAVRRMVRQFNFTVWPDKGVPQYATAVLAFRRKVRALNPR--DAGPVIVHCSAGV
||..|||   ... |||..||||  .||  ..||..||. .   .    |.|..| .| ||| |||.... .|.| ..||  ..   . |||.|||||||
kcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGv

GRTGAYIVIDAMLEQAK---INRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEI
||.|..|..| ||.| .   ....||| ...  ||. ||..||| ||| |.. |.|| | ...| .
gRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltke
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 321-589 9.3e-89 292.3 In-house 10-278 (288) alignment 
Range on Protein: 321-589
Range on HMM: 10-278/288.0
KYVAIMQANRGIRLEAEYKNVSN-EQQFSWDAARKAANKKKNRYGNIVTYDHSRVVLERVNGDEDSDYINASFIHGfDGTPRSYIASQGPPPPTFEGFWR
..||...|.    .. ||..... |.. | .|.|.| |.||||| ||..||. || |. ..  ...||||||.|.| ..  . |||.||| . | . ||.
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidg.ekkkkkyiatqgPladtvndfWe

MVWEQNSQSIVMLTNLVELGKTKCHKYWPEKTE--TYGGVTVTLHQTEVFADYVIRTFILFreERAVRRMVRQFNFTVWPDKGVPQYATAVLAFRRKVRA
.|.|.... |||||.||| |||||..|||.. .   || ||||| ...   |.| |...|    .  .. . |.....|||.|||. .. .|...|.|  
lvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkv

LNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
 |. |.||.|||||||||||| .|..||.... . . ..|. . .  ||| |. .|||..|| ||....|. 
anqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsl
0045450 (Phosphotyrosine protein) phosphatases II 310-590 1.1e-87 290.0 In-house 5-304 (307) alignment 
Range on Protein: 310-590
Range on HMM: 5-304/307.0
LSKPISVAHFPKYVAIMQANRGIRLEAEYKNVSNEQQF---SWDAARKAANKKKNRYGNIVTYDHSRVVLERVNGD-EDSDYINASFI--------HGFD
||..|.. .. ..|......   .|..|.. . ... |   ....|.. .||.|||| .|. |||.||.|  ..|. |||||||||..        .|.|
lslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgyd

GtPRSYIASQGPPPPTFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPEK--TETYGGVTVTLHQTEVFADYVIRTFILFRE-ERAVRRMVRQFNFT
  .| .|| ||| | |.| ||||.|||... |||||.|||||. ||..|||..  . ||| .||||  .|. ..|..||. . .  .    |.|..| .|
l.krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhyt

VWPDKGVPQYATAVLAFRRKVRALNPR--DAGPVIVHCSAGVGRTGAYIVIDAMLEQAKINRT---VDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
 ||| |||..   .|.| ..||. . .  . |||.|||||||||||..|... ||.| . . |   ||... .  ||. ||..||. ||| |.. |.|| 
gwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel

L
|
l
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 326-591 3.7e-87 287.0 In-house 9-277 (281) alignment 
Range on Protein: 326-591
Range on HMM: 9-277/281.0
MQANRGIRLEAEYKNVSN-EQQFSWDAARKAANKKKNRYGNIVTYDHSRVVLERVNGDEDSDYINASFIHGFDGtPRSYIASQGPPPPTFEGFWRMVWEQ
...|    .  ||..... ... .  |... .|..|||| ||| ||..||.... . ....|||||.|. |..| .. |||.||| | ... ||.|||||
lsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykg.ekeyiatqgPvPaslvafWqmvweq

NSQSIVMLTNLVELGKTKCHKYWPEKT--ETYGGVTVTLHQTEVFADYVIRTFILfREERAVRRMVRQFNFTVWPDKGVPQYATAVLAFRRKV-RALNPR
. . |||.|. .| || |||.|||...   .|| |||. ...|  | |. |.| | ..| .  | |.|...| |||.|||. ....| ||..| .. ...
kvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekk

DAGPVIVHCSAGVGRTGAYIVIDAMLEQAKI-NRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALT
   |...||||||||||.|| .| ......  ....|... .  |||.|  ||||  ||.|.. |||.|| 
tkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
0047943 (Phosphotyrosine protein) phosphatases II 329-590 3.8e-87 287.5 In-house 9-272 (273) alignment 
Range on Protein: 329-590
Range on HMM: 9-272/273.0
NRGIRLEAEYKNVSNEQ-QFSWDAARKAANKKKNRYGNIVTYDHSRVVLervnGDEDSDYINASFIHGFDGTPRsYIASQGPPPPTFEGFWRMVWEQNSQ
.   .|..|.. . . . .... .|.. .||.|||| .|. ||||||.|    ||..|||||||.. |.. ... .|| ||| | |.| |||||||||..
lgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrk.fiatqgPlpntvedfwrmvweqnvr

SIVMLTNLVELGKTKCHKYWPEK----TETYGGVTVTLHQTEVFADYVIRTFILFREERAVRRMVRQFNFTVWPDKGVPQYATAVLAFRRKVRALNPR--
 |||||.|||||. ||..|||..    ..||| .||||  .|...||..||..| . .    |.|..| .| ||| |||.. . .| | ..||  .    
viVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealp

DAGPVIVHCSAGVGRTGAYIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
. |||.|||||||||||..|..| .|.| . ...||. ...  ||. ||.|||| ||| |.. |.|| |
sngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0050432 (Phosphotyrosine protein) phosphatases II 585-889 5e-85 280.8 In-house 7-305 (308) alignment 
Range on Protein: 585-889
Range on HMM: 7-305/308.0
AVLEALTCGNTEIQSENFNQTTQKLAS-VNRKFQMTGYALEFQRLNSFTSreipAEEKSVGEEPQNLQKNRFCDIVALNSCRVMLrkehaDEESDYINAV
|.||.|....|.|. ...... ..|.  ..........  ||..|.|..      .| ||.. |.|  |||. ||... ..|| |     ||.|||||| 
allelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkp....lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAs

FLHAH--RERNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELD-QEYPQYWPDH---GATKYGHIGVSVLSKQEKGDVISTKLEVTRKKVRrKT
. . .  . ...|||||.|| .||||||||| .... .||||..|.| . . ..||||.    | ..||.. | .|| ....|.. ..||.| ..   ..
yvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg.es

HEVRHLHHVSWPDKCIPEVACSVLDLLDDVQTSQqqcGNAPVLVQCSNGVGRSGTFCVISSVIERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQ
..|.|.|. .||| ..|. . ..||.|. |..|.   .. |..| ||.||||.|||...  ..|.|..|. .|||...|..|  |||.|... ||.|.|.
rtvthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyr

IIQKYLGSFSDY
....|| ..  .
alleylklkltk
DSPc_SM00195 335-590 4.3e-83 274.0 In-house 3-262 (263) alignment 
Range on Protein: 335-590
Range on HMM: 3-262/263.0
EAEYKNVSNEQ-QFSWDAARKAANKKKNRYGNIVTYDHSRVVLERVNGDEDSDYINASFIHGFdGTPRSYIASQGPPPPTFEGFWRMVWEQNSQSIVMLT
..|.... ... . . . |.| .||.|||| ||. |||.|| |.. ...|.||||||..| |    ...||| ||| | |.| |||||||.... |||||
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NLVELGKTKCHKYWPEK---TETYGGVTVTLHQTEVFA-DYVIRTFILFREERAVRRMVRQFNFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVH
. .| ||.||..||||.   .||.| ..|.| ..|    ....||. |  |..   | |.|.... |||.|||. .. ||.. |.|.  . .  ||..||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGVGRTGAYIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
|||||||||....|| .|.. . . .||| . . .||| ||.||||.|||.||. |.||..
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 335-590 4.3e-83 274.0 In-house 3-262 (263) alignment 
Range on Protein: 335-590
Range on HMM: 3-262/263.0
EAEYKNVSNEQ-QFSWDAARKAANKKKNRYGNIVTYDHSRVVLERVNGDEDSDYINASFIHGFdGTPRSYIASQGPPPPTFEGFWRMVWEQNSQSIVMLT
..|.... ... . . . |.| .||.|||| ||. |||.|| |.. ...|.||||||..| |    ...||| ||| | |.| |||||||.... |||||
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NLVELGKTKCHKYWPEK---TETYGGVTVTLHQTEVFA-DYVIRTFILFREERAVRRMVRQFNFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVH
. .| ||.||..||||.   .||.| ..|.| ..|    ....||. |  |..   | |.|.... |||.|||. .. ||.. |.|.  . .  ||..||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGVGRTGAYIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
|||||||||....|| .|.. . . .||| . . .||| ||.||||.|||.||. |.||..
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0051299 (Phosphotyrosine protein) phosphatases II 593-883 2.4e-82 271.9 In-house 1-286 (288) alignment 
Range on Protein: 593-883
Range on HMM: 1-286/288.0
GNTEIQSENFNQTTQKLAsvnrKFQMTGYALEFQRLNSFTSReipaEEKSVGEEPQNLQKNRFCDIVALNSCRVMLRKEHADEESDYINAVFLHAHRERN
|.|||. |.. .. .||     . ..||.. ||..| |..       . |..  |.||.|||. ||......|| |. .. .|.|||||| ... ..  .
gdteisveellklvlkll....angltglleefeellsllpd....ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkr

AFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELD-QEYPQYWPDHGATKYGHIGVSVLSKQEKGDVISTKLEVTRKK---VRRKTHEVRHLHHVSW
.|||||.|| .||||||||| .... .||||..|.||. . ..||||..| ..||.| |  || ....|.. ..||||...      ....|.|.|. .|
kfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnw

PDKCIPEVACSVLDLLDDVQTSQQqCGNAPVLVQCSNGVGRSGTFCVISSVIERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKYL
|| ..|. . ..||.| .|.....  |. ||.| ||.||||.|||...  ..|.|..|...||....||.|  |||.|... ||.|.|...  ||
pdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 313-634 2.7e-82 271.5 In-house 1-320 (515) alignment 
Range on Protein: 313-634
Range on HMM: 1-320/515.0
PISVAHFPKYVAimQANRGIRLEAEYKNVSNEQQFSWDAARKAANKKKNRYGNIVTYDHSRVVLERVNGDEDSDYINASFIHGFDGtPRSYIASQGPPPP
|. .| || .|.  ....   .  |....   . .    |..  | |||||.||. || .|| || .| . .|||.|||.|..||   ..||||||| . 
plplaqfPafvn..knrhttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdn.dkayiasqgPnka

TFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPE---KTETYGGVTVTLHQTEVFADYVIRTFILFREERavRRMVRQFNFTVWPDKGVPQYATAVL
. . |||.|...|   |.|.|.| |  | || ||||.   ..  .| . | |  .|  .. ..|.. . ...    | | ||.|| |||||||. ....|
svddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssll

AFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENFNQTTQKL
 . ..|.| . . . |.|.|||||||||| .| || .. .||  |.||. |..  .|..||..|||.|||.||. |||| |   || |    | .  | |
klikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdl

ASVNRKFQMTGYALEFQRLNSFTSR
 |       .  . ||| |.|..  
hssgdgrgrskmtkefqtlkslcpd
subfamily_Ptp69D_pd Subfamily Ptp69D 324-609 3.6e-82 270.9 In-house 14-305 (307) alignment 
Range on Protein: 324-609
Range on HMM: 14-305/307.0
AIMQANRGIRLEAEYKNVS-NEQQFSWDAARKAANKKKNRYGNIVTYDHSRVVLERVNGDEDSDYINASFIHGFDGTpRSYIASQGPPPPTFEGFWRMVW
   . .    |. ||...  .| . |  .. |  |. |||| .|...|. ||.|...||.|||||||||||.|.. . ...||.|.|   | . ||||..
ksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykek.kkfiaaqdPveatigDfWRmia

EQNSQSIVMLTNLVELGKTKCHKYWP-EKTETYGGVTVTLHQTEVFADYVIRTFILFREERAV-----RRMVRQFNFTVWPDKGVPQYATAVLAFRRKVR
||... ||||.|| |  . ||.|||| |..  || . |.| ..|   ||.||.. . . .  .     .| | |...| |.|  ||. |...| . ..||
eqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvr

ALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENFNQTTQKL
 |.  . .|..|||||||||.| .. .| .|.| | . .||| .    ||..|. .||  |||.|.. |.|.  . |.|... ...... ..|
elyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledaierl
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 312-612 3.3e-81 267.6 In-house 1-299 (315) alignment 
Range on Protein: 312-612
Range on HMM: 1-299/315.0
KPISVAHFPKYVAimQANRGIRLEAEYKNVSNEQQFSWDAARKAANKKKNRYGNIVTYDHSRVVLERVNGDEDSDYINASFIHGFDGtPRSYIASQGPPP
.|| ||.|| .|   .  .   .  |.... . . .   .||.  | |||||.||. .|..||.|| .. . ||||||||.|...|   ..||||||| .
qpipvaqfpafvn..knrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdd.dkayiasqgPlk

PTFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPE---KTETYGGVTVTLHQTEVFADYVIRTFiLFREERAVrRMVRQFNFTVWPDKGVPQYATAV
 . . |||||....  .|||.|.. |  | || .|||.   ..  .| . |.| ..|  .| |.| .   |.  .  | | ||.|| ||||||.. ....
asvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrksees.rtvtqfqftewPdkGvdkqtssl

LAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENFNQTTQK
| . ..|.| | ..  ...|||||||||||  | || ...|.| .|.||. |..  ||..||..|||.|.|.||. |||| |   || |   .| .  | 
lklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqd

LASV
| . 
lhts
0040439 (Phosphotyrosine protein) phosphatases II 349-590 1.5e-80 265.7 In-house 3-246 (249) alignment 
Range on Protein: 349-590
Range on HMM: 3-246/249.0
WDAARKAANKKKNRYGNIVTYDHSRVVLERVNGDEDSDYINASFIHGFDGTPRsYIASQGPPPPTFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP
.. |.. .||.|||| .|. ||||||.|. ..| ..|||||||.|.|.. ..| .|| ||| | |.| ||||.||.....|||||.|||||. ||..|||
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr.fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

-EKTETYGGVTVTLHQTEVFADYVIRTFILFREERAVRRMVRQFNFTVWPDKGVPQYATAVLAFRRKVRALNPR--DAGPVIVHCSAGVGRTGAYIVIDA
 ... .||..|||| ..||..||..||. | . .    |.|.....| ||| |||..   .|.| ..||  . .  . |||.|||||||||||..|... 
lggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

MLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
|||| . ...||. ...  ||. ||..||. ||| |.. |.|| |
mleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 624-893 9.2e-80 263.1 In-house 25-290 (318) alignment 
Range on Protein: 624-893
Range on HMM: 25-290/318.0
EFQRLNSftSREIPAEEKSvgEEPQNLQKNRFCDIVALNSCRVMLRKEHADEESDYINAVFLHAHRERNAFIATQHPLLETVEDFWRMVTDYDIGTIVML
|..||.   |.| ... ||   || | .|||. .|.| ...|| |.. . .|.|||||| ..  .|...|.||.| || ||.||||||| . .  .||||
eyerlsr..seetvtslks..lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivml

NNLHELDQ-EYPQYWPDHGATKYGHIGVSVLSKQEKGDVISTKLEVTRKKVRrKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQTSQQQCGNAPVLVQ
 ...|  .    .|||..|...||.. | . .. | .| .  ...|||...  .. .||  |. ||||. .|| ..|.|||. .|.. ||..|. |..| 
tqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteee.esrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvh

CSNGVGRSGTFCVISSVIERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKYLGSFSDYANFS
|| |||| |.|.......||.| |...||||..|..| .|.  |    ||.|.|......| |.  ... |
CsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdas
subfamily_PTPN12_pd Subfamily PTPN12 333-590 2.5e-79 261.2 In-house 16-277 (290) alignment 
Range on Protein: 333-590
Range on HMM: 16-277/290.0
RLEAEYKNVSNEQQFSWDAARKAANKKKNRYGNIVTYDHSRVVLERVNGDEDSDYINASFIHGFDGTpRSYIASQGPPPPTFEGFWRMVWEQNSQSIVML
.| .. ..  .|...| .|..|  |.||||| .|. ||.|||.|.. ...|.||||||.||.| .|.  .|||.||| | | . ||||.||.| . .||.
klkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegk.leyiaaqgPLpktlddfWrmiweknveivvma

TNLVELGKTKCHKYWPEKT---ETYGGVTVTLHQTEVFA-DYVIRTFILFREerAVRRMVRQFNFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIV
 ..|||||.||..||||..    ..| ..|||.. . .  |..|||. . ..    .|.|.||..| |||.|||. |. .|.. ..|| |. ... |..|
CrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvv

HCSAGVGRTGAYIVIDA---MLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
||||||||||. |.||    .|.. ||. ..|. . .. |||.|. .|||||||.... ||.| .
hCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
0046845 (Phosphotyrosine protein) phosphatases II 623-888 2.9e-79 261.7 In-house 4-279 (284) alignment 
Range on Protein: 623-888
Range on HMM: 4-279/284.0
LEFQRLNSFTSREIpaEEKSVGEEPQNLQKNRFCDIVALNSCRVMLRKEHAD-EESDYINAVFLHAH-----RERNAFIATQHPLLETVEDFWRMVTDYD
 ||..|.|.|   .   . ||.  |.|| |||. ||......|| |. .. | |.|||||| ... .     . ...|||||.|| .||||||||| ...
eefeellsltvkll..lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

IGTIVMLNNLHELDQ-EYPQYWPDHG-ATKYGHIGVSVLSKQEKGDVISTKLEVTRKKVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQTSQQQ-
. .||||..|.| ..  ..||||. |   .||.. | .||...|.|.. ..||.|....  ....|.|.|. |||| ..|. . ..|..|..|...... 
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

CGNAPVLVQCSNGVGRSGTFCVISSVIERLKTEQ---VIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKYLGSFSD
 |. |..| ||.||||.|||...  ..|.|..|.   ..||....||.|  |||.|..| ||.|.|.... || ..  
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 333-610 6.9e-79 260.4 In-house 35-311 (319) alignment 
Range on Protein: 333-610
Range on HMM: 35-311/319.0
RLEAEYKNVSNEQQFSWD--AARKAANKKKNRYGNIVTYDHSRVVLERVNGDEDSDYINASFIHGFDgTPRSYIASQGPPPPTFEGFWRMVWEQNSQSIV
.||.|......      |   |    || |||..||...|...| |||..| | ||||||||. |.   .  |||.||| . | . ||||.||.|. .||
klevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyq.rkdkyiaaqGPldntladfWrmiweyncstiv

MLTnlvelgKTKCHKYWPEKT-ETYGGVTVTLHQTEVFADYVIRTFILFR-EERAVRRMVRQFNFTVWPDKGVPQYATAVLAFRRKVRALNPRDAG--PV
.||      | || .||| |. ....   | ..  |  |.||.| . | .  .    | ..|| |  |||.|||.|.. .. . .||| |. .  .  ..
llt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhrani

IVHCSAGVGRTGAYIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENFNQTTQKLA
.|||||||||||.|||.|..|.. | .. ||. |..  ||..|...||   || ||.||.||    |....   .|    ..|.
vvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleels
0042113 (Phosphotyrosine protein) phosphatases II 350-589 7.3e-79 259.9 In-house 2-242 (245) alignment 
Range on Protein: 350-589
Range on HMM: 2-242/245.0
DAARKAANKKKNRYGNIVTYDHSRVVLERVNGDEDSDYINASFIHGFDGTPRsYIASQGPPPPTFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP-
. |.. .||.|||| .|. |||.||.|  ..||.||||||||...|.. ||. .||.||| | |.| ||||.||.....|||||...|||. ||..||| 
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpk.fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl

EKTETYGGVTVTLHQTEVFADYVIRTFILFREERAVRRMVRQFNFTVWPDKGVPQYATAVLAFRRKVRALNP-RDAGPVIVHCSAGVGRTGAYIVIDAML
. . |||..||||  .|...||..||. . ..     |.|... .. ||| ||| .   .| | . ||      . |||.|||||||||||..|... ||
gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylml

EQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
||.. ...|.. . .  ||. ||..||| .|| |.. |.|| 
eqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
Y_phosphatase Protein-tyrosine phosphatase 357-588 8.2e-79 259.7 Pfam-A 1-235 (235) alignment 
Range on Protein: 357-588
Range on HMM: 1-235/235.0
NKKKNRYGNIVTYDHSRVVLervNGDED-SDYINASFIHGFDgTPRSYIASQGPPPPTFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP---EKTE
||||||| .|. ||..|| |   .|.|. ||||||....|.. .....||.||| . |.| ||||||......|||||.|.| |..||..|||   |...
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

TYGGVTVTLH-QTE-VFADYVIRTFILFREERA-VRRMVRQFNFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQ
||| ..|.|  ...   ..|..|.. |  ...   .|.|.|. .| |||.|||. ....| . |||.  .  . |||.||||||||||| ....|..|||
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

AKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
.. ...||. ...  ||| ||.|||. ||| |.. |.||
leaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 357-588 8.2e-79 259.7 In-house 1-235 (235) alignment 
Range on Protein: 357-588
Range on HMM: 1-235/235.0
NKKKNRYGNIVTYDHSRVVLervNGDED-SDYINASFIHGFDgTPRSYIASQGPPPPTFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP---EKTE
||||||| .|. ||..|| |   .|.|. ||||||....|.. .....||.||| . |.| ||||||......|||||.|.| |..||..|||   |...
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

TYGGVTVTLH-QTE-VFADYVIRTFILFREERA-VRRMVRQFNFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQ
||| ..|.|  ...   ..|..|.. |  ...   .|.|.|. .| |||.|||. ....| . |||.  .  . |||.||||||||||| ....|..|||
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

AKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
.. ...||. ...  ||| ||.|||. ||| |.. |.||
leaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_PTPN6_pd Subfamily PTPN6 336-588 9.9e-79 259.5 In-house 30-295 (306) alignment 
Range on Protein: 336-588
Range on HMM: 30-295/306.0
AEYKNV---SNEQQFSWDAARKAANKKKNRYGNIVTYDHSRVVLErVNGDEDSDYINASFIH-GFDGTPRSYIASQGPPPPTFEGFWRMVWEQNSQSIVM
 |....    .....| . ..|. ||.|||| ||. .||.||.|.  ..  .||||||..|.  . |. .||||.||  . | . ||||||..||. |||
eefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivm

LTNLVELGKTKCHKYWPEK--TETYGGVTVTLHQTEVFADYVIRTFILF-REERAVRRMVRQFNFTVWPDKGVPQYATAVLAFRRKVRA----LNPRDAG
.|. || || || .|||..  .|.|| ..||  . .  |||..|.. .  ...    | |.|..|..|||.|||.   |||.| ..|..    |. ..||
ttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeag

PVIVHCSAGVGRTGAYIVIDAMLEQA---KINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
|..||||||.||||..||||..|..    ...  .||..    .|. |  .|||..|| |.. |. .
pivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikk
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 312-602 5.1e-78 257.2 In-house 8-296 (297) alignment 
Range on Protein: 312-602
Range on HMM: 8-296/297.0
KPISVAHFPkyvAIMQANRGIRLEAEYKNVSNEQ-QFSWDAARKAANKKKNRYGNIVTYDHSRVVLERVNGDEDSDYINASFIHGFDGtprSYIASQGPP
.|| ...|.   ...| ||   .. |  .   |   ..   |.|  | .|.|| ||. || ||| |. || | ||||.||||..|.      .|..| | 
rpiplsdfa...tlvqknrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh...rlittqmPm

PPTFEGFWRMVWEQNSQSIVMLTNLVELGKtKCHKYWPEKT-ETYGGVTVTLHQTEVFADYVIRTFILFREERAVRRMVRQFNFTVWPDKGVPQ--YATA
. | . ||.||.... . ||||... |  | || .||..|.  |.| |.|.|. ..    .. |.. . ...  .||.|.|..|. |||| |..   |..
katvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsass

VLAFRRKVRALNPRDAG-PVIVHCSAGVGRTGAYIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENF
.| .   ||      |  |..|||.||||||| .. || .. .|| . .||| ...  ||..||..|||||||.|.. |||||| . .|.||.. |
llklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqasyf
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 618-887 1.3e-77 256.0 In-house 22-287 (319) alignment 
Range on Protein: 618-887
Range on HMM: 22-287/319.0
MTGYALEFQRLNSFTSReipaeEKSVGEEPQNLQKNRFCDIVALNSCRVMLRKEHADEESDYINAVFLHAHRERNAFIATQHPLLETVEDFWRMVTDYDI
.|. . ||. |.  ..      . .  ....| .|||. .|.| . .||.| . .  |.|||||| |. ...||..||||| || .|.||||||| ....
etllekefkllkeavnd.....tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeees

GTIVMLNNLHE-LDQEYPQYWPDHGATKYGHIGVSVLSKQEKGDVISTKLEVTRKKVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQTSQQQCGN
 ..|||..| | |. .. .|||..  ..||.. | .....|. |.|  ||.. .|.   .| || | .. .|||. .|| | |.|||| ... |...  .
sivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqs

APVLVQCSNGVGRSGTFCVISSVIERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKYLGSFS
 |. | ||.|||| |||.|.. ..||.| |.|.|||....|.|. |.  |.   || |.|... ... ...
gPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd
0045098 (Phosphotyrosine protein) phosphatases II 348-593 2.5e-77 255.3 In-house 24-275 (278) alignment 
Range on Protein: 348-593
Range on HMM: 24-275/278.0
SWDAARKAANKKKNRYGNIVTYDHSRVVlervngdedsDYINASFIHGFdgtPRSYIASQGPPPPTFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYW
..  | .  |..|||| .|. ||||||.          ||||||.|.|.   |. .|| ||| | |.. ||||.||.....|||||.|||||. ||..||
eitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy...pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqyw

PEKT-ETYGGVTVTLHQTEVFADYVIRTFILFRE----ERAVRRMVRQFNFTVWPDKGVPQYA--TAVLAFRRKVRALNPR-------------DAGPVI
||.  .|||..|||| ..||. ||..||...       |    | |...... ||| ||| .   . .| . . .|. . .             . |||.
peggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvl

VHCSAGVGRTGAYIVIDAMLEQAkiNRTVDIRNYLIALRKDRPH-MVQTKEQYSFIHSAVLEALTCG
|||||||||||...... |||.   ...||. ...  ||. ||. .||..||| |.. ..|| | .|
VHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 352-610 3.1e-77 254.9 In-house 20-275 (284) alignment 
Range on Protein: 352-610
Range on HMM: 20-275/284.0
ARKAANKKKNRYGNIVTYDHSRVVLERVNGDEDSDYINASFIHGFDgTPRSYIASQGPPPPTFEGFWRMVWEQNSQSIVMLTnlvelgKTKCHKYWPEKT
|    || |||.|.|...|...| |||. | | ||||||||| |.   .  |||.||| . | . ||||.||.|. .||.||      | || .||| |.
anldqnkdknrighilafdknvvklerliGeefsdyinasfitGyq.rkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplki

-ETYGGVTVTLHQTEVFADYVIRTFILFR-EERAVRRMVRQFNFTVWPDKGVPQYATAVLAFRRKVRALNPRDAG--PVIVHCSAGVGRTGAYIVIDAML
 ....   | ..  |  ..||.| . | .  .    | .||| |  |||.|||.|.. .... .||| |. .  .  ...|||||||||||.|||.|..|
vikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvll

EQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENFNQTTQKLA
.. | .. ||. |..  ||..|...||   || ||.||.||    |....   .|    ..|.
drmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleels
0036941 (Phosphotyrosine protein) phosphatases II 611-885 3.4e-77 255.0 In-house 5-279 (297) alignment 
Range on Protein: 611-885
Range on HMM: 5-279/297.0
SVNRKFQMTGYALEFQRLnsftSREIPAEEKSVGEEPQNLQKNRFCDIVALNSCRVMLrkehADEESDYINAVFLHAHRERNAFIATQHPLLETVEDFWR
 ..........  ||..|     . ..  ..||.. |.||.|||. ||......|| |     ||.|||||| ..  ..  ..|||||.|| .|||||||
llekllflalllkefeel....lpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWr

MVTDYDIGTIVMLNNLHELDQ-EYPQYWPDH--GATKYGHIGVSVLSKQE--KGDVISTKLEVTRKKVRrKTHEVRHLHHVSWPDKCIPEVACSVLDLLD
|| .... .||||..| ||.   ..||||.   .  .||.. | .|| ..  ..|.. ..|||| ..   ....|.|.|. .||| ..|| . |.||...
mvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgng.esrtvthfhytgwpdhgvpespaslldfie

DVQTSQQQC-GNAPVLVQCSNGVGRSGTFCVISSVIERLK---TEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKYLGS
 |.. ...  .. |||| ||.||||||||...  ....|.   .|. .|.....| .|  |||||..| ||.|.|......| .
lvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkk
0040438 (Phosphotyrosine protein) phosphatases II 616-883 5.9e-77 254.4 In-house 15-276 (317) alignment 
Range on Protein: 616-883
Range on HMM: 15-276/317.0
FQMTGYALEFQRLNSFtsreiPAEEKSVGEEPQNLQKNRFCDIVALNSCRVMLRKEHADEESDYINAVFLHAHRERNAFIATQHPLLETVEDFWRMVTDY
 ..|.   ||..| |.     . .. ||.| |.| .|||. ||. . ..|| |  .  |..|||||| . . ......|||||.|| .||||||||| ..
sdftalleefedllsl.....kldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweq

DIGTIVMLNNLHELD-QEYPQYWPDHGATKYGHIGVSVLSKQEKGDVISTKLEVTRKkVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQTSQQqC
....||||..| ||. . . ||||. . ..||.. | .|| .|..... ..|||. .    ....|.|.|. .||| ..|.   ..||.|. |.....  
gvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavreale.d

GNAPVLVQCSNGVGRSGTFCVISSVIERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKYL
.. |||| ||.||||.|||...  ..|.|..|. .||....|..|  |||||... ||.|.|.....||
pggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
0047943 (Phosphotyrosine protein) phosphatases II 612-883 2.3e-76 252.2 In-house 5-272 (273) alignment 
Range on Protein: 612-883
Range on HMM: 5-272/273.0
VNRKFQMTGYALEFQRLNSFTSreipAEEKSVGEEPQNLQKNRFCDIVALNSCRVMLrkehADEESDYINAVFLHAHRERNAFIATQHPLLETVEDFWRM
.......|....||..| |..       ..||.. |.|..|||. ||......|| |     |..|||||| ..  ..  ..|||||.|| .||||||||
lekllgltllleefelllslkp....lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrm

VTDYDIGTIVMLNNLHELDQ-EYPQYWPDHG---ATKYGHIGVSVLSKQEKGDVISTKLEVTRKKVRRkTHEVRHLHHVSWPDKCIPEVACSVLDLLDDV
| .... .||||..|.||..  ..||||. |    ..||.. | .|| ..|.|.. ..||.|...    ...|.|.|. .||| ..|.   |.|.....|
vweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielv

QTSQQQC-GNAPVLVQCSNGVGRSGTFCVISSVIERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKYL
.. .... .| ||.| ||.||||.|||...  ....|..|. .||....|..|  |||.|... ||.|.|... .||
rkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0039614 (Phosphotyrosine protein) phosphatases II 612-886 2.6e-76 252.2 In-house 25-292 (297) alignment 
Range on Protein: 612-886
Range on HMM: 25-292/297.0
VNRKFQMTGYALEFQRLNSFTSreipaEeKSVGEEPQNLQKNRFCDIVALNSCRVMLRKEHA-DEESDYINAVFLHAHRE-RNAFIATQHPLLETVEDFW
.......|.. |||..| |..      . .|... |.|  |||. ||......|| |  |   |..|||||| ..  ..   ..|||||.|| |||||||
lekansktllllefeellslkp.....d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFw

RMVTDYDIGTIVMLNNLHELDQEYPQYWPDHGAtKYGHIGVSVLSKQEKGDVISTKLEVTRkkvRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQT
||| .... .||||..| ||.. ..||||. |  .||.. | .|. ....... ..||||.     ....|.|.....||| ..|. . ..|..|. |..
rmvweqgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtlevtn...ngesrtvthfqytgwpdhgvppslellleflelvre

SQQQC-GNAPVLVQCSNGVGRSGTFCVISSVIERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKYLGSF
 .... .. |||| ||.||||.|||...  ..|.|..|. .||....|..|  |||||... ||.|.|......|  .
alaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
subfamily_PTPRA_pd Subfamily PTPRA 629-882 1.1e-75 249.6 In-house 39-294 (330) alignment 
Range on Protein: 629-882
Range on HMM: 39-294/330.0
NSFTSREIPAEEKSVgEEPQNLQKNRFCDIVALNSCRVMLRKEHADEESDYINAVFLHAHRERNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHE
|.. . .| |  .   .. .| .|||. .|.  .  ||.| . .  |||||||| |.. ..|.. |||.| |. |||||||||. ...  ||||| .|.|
nalPagpiqatlela.skeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelke

LDQEY-PQYWPDHGATKYGHIGVSVLSKQEKGDVISTKLEVTR---KKVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQTSQQQCGNaPVLVQCS
 ..|   |||||.|.  ||.| |.|  ...  |.   |. |..   .. ..|.  || .|  ||||  .|  .  .|.||  |.. .|| .. |. | ||
rkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcs

NGVGRSGTFCVISSVIERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKY
 ||||.|||.|...|.||.|.|...|||...||.| .||  | .. ||.|.|.....|
aGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 638-886 3.7e-75 247.9 In-house 35-286 (305) alignment 
Range on Protein: 638-886
Range on HMM: 35-286/305.0
AEEKSVGEEPQNLQKNRFCDIVALNSCRVMLRKEHADEESDYINAVFLHAHRERNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQEY-PQY
 |   ||.. .| .|||. .|. |.  |..|.... ...|||||| ...........|..| || .||.||||.. .. . ||||| .| | ...   ||
eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqY

WPDHGAT--KYGHIGVSVLSKQEKGDVISTKLEVTRKKVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQTSQQQCGNAPVLVQCSNGVGRSGTFC
||.  .   ..|.. | . |...  | |  ||... ..  .... | ...  .|||. .|. | |.|.|...|| .|..  . |.|| ||.||||.|.|.
WpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfi

VISSVIERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKYLGSF
...  .||||.|.|.|||.|.|..| .|...|..| ||||......... ..
avdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg
0037934 (Phosphotyrosine protein) phosphatases II 349-588 1.4e-74 246.0 In-house 2-240 (243) alignment 
Range on Protein: 349-588
Range on HMM: 2-240/243.0
WDAARKAANKKKNRYGNIVTYDHSRVVLervngdEDSDYINASFIHGFDgtpRsYIASQGPPPPTFEG----FWRMVWEQNSQSIVMLTNLVELGKTKCH
.  |.. .|..|||| .|..||||||.|      |.||||||..| ...   | .||.||| | |.|     ||||.||.....|||||.|||||. ||.
fsiallpenlsknrysdilpydhsrvkl......egsdyinanliyvtp...r.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekca

KYWPEKTeTYGGVTVTLHQTEVFADYVIRTFILFREE-RAVRRMVRQFNFTVWPDKGVPQYATAVLAFRRKVRAL--------NPRDAGPVIVHCSAGVG
.|||... |||..|||| ..|...||..||. | . .   . |.|... .. ||| |||.  . .|.| ..||.         .  . |||.||||||||
qywpgev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvg

RTGAYIVIDAMLEQAkinrTVDIRNYLIALRKDRPH-MVQTKEQYSFIHSAVLE
|||..|... ||..     .||. ...  ||. ||. .||| .|| |.. |.||
RtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
DSPc_SM00195 624-883 6.4e-74 244.0 In-house 5-262 (263) alignment 
Range on Protein: 624-883
Range on HMM: 5-262/263.0
EFQRLNSFTSREipaeEKSVGEEPQNLQKNRFCDIVALNSCRVMLRKEHADEESDYINAVFLHAHRERNAFIATQHPLLETVEDFWRMVTDYDIGTIVML
||..|.. || .    |.. .|...| .|||. .|.  .. || | ||. .|.|||||| ..  .......||||.|| .|||||||||.. .. .||||
efekleestspk....etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

NNLHEL-DQEYPQYWPDH--GATKYGHIGVSVLSKQEKG-DVISTKLEVTRKKVrRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQTSQQQCgNAPV
..  |   ..  .|||.   | ...|.| | . ....|  ..| ..||.| ..  ..|..|..... .|||. .|. . |||.||  |..|...  ..|.
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpi

LVQCSNGVGRSGTFCVISSVIERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKYL
.|.||.||||.|||..|......|..|. .|.|...|..| .|||.|..|.|| |.|..| .|.
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 624-883 6.4e-74 244.0 In-house 5-262 (263) alignment 
Range on Protein: 624-883
Range on HMM: 5-262/263.0
EFQRLNSFTSREipaeEKSVGEEPQNLQKNRFCDIVALNSCRVMLRKEHADEESDYINAVFLHAHRERNAFIATQHPLLETVEDFWRMVTDYDIGTIVML
||..|.. || .    |.. .|...| .|||. .|.  .. || | ||. .|.|||||| ..  .......||||.|| .|||||||||.. .. .||||
efekleestspk....etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

NNLHEL-DQEYPQYWPDH--GATKYGHIGVSVLSKQEKG-DVISTKLEVTRKKVrRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQTSQQQCgNAPV
..  |   ..  .|||.   | ...|.| | . ....|  ..| ..||.| ..  ..|..|..... .|||. .|. . |||.||  |..|...  ..|.
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpi

LVQCSNGVGRSGTFCVISSVIERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKYL
.|.||.||||.|||..|......|..|. .|.|...|..| .|||.|..|.|| |.|..| .|.
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0045450 (Phosphotyrosine protein) phosphatases II 618-883 1.4e-73 243.6 In-house 26-304 (307) alignment 
Range on Protein: 618-883
Range on HMM: 26-304/307.0
MTGYALEFQRLNSFTSREipAEEKSVGEEPQNLQKNRFCDIVALNSCRVMLRKEHAD-EESDYINAVFL--------HAHRERNAFIATQHPLLETVEDF
.||.. ||..|.|.| .     | |... |.|  |||. ||......|| |  .. . |.|||||| .         . ..  ..|||||.|| ||||||
ltgllkefekllsvtvfl..lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedF

WRMVTDYDIGTIVMLNNLHELDQE-YPQYWPDHGAT-KYGHIGVSVLSKQEKGDVISTKLEVTRKKVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDD
|||. ......||||..| ||..| ..||||| | .  ||.. | .||........ ..||||...   ....|.|.|. .||| ..|.   ..||... 
wrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfiee

VQTSQQQC-GNAPVLVQCSNGVGRSGTFCVISSVIERLKTEQV---IDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKYL
|.. .... .. |||| || ||||.|||...  ....|..|..   .|.....|..|  |||||... ||.|.|......|
vrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 327-613 5.2e-73 241.0 In-house 18-311 (325) alignment 
Range on Protein: 327-613
Range on HMM: 18-311/325.0
QANRGIRLEAEYKNVSNEQQFSWDAARKAANKKKNRYGNIVTYDHSRVVLERVNGDEDSDYINASFIHGFDGTpRSYIASQGPPPPTFEGFWRMV--WEq
.|.    .  |.. . ...  .  .| | .||.|||. |.|..|.||||||  . | .|||||||... . .    ..|.| | . | . .||.|  |. 
kaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkk.dvflaaqaPltatindlWrlvldWr.

nsQSIVMLTNLVELGKTKCHKYWPEK---TETYGGVTVTLHQTEVFADYVIRTFILFREERAVRRMVRQFNFTVWPDKGVPQYATAVLAFRRKVRAL---
   |.|...| ..||| .| .|||..   . |.||. | |   | ..||| | . . . ..   | |.||..  |.| ||... ...... . | |.   
..csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavser

---NPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENFNQTTQKLASVN
   | . ..|..|||||||||||..| . ..|..   .  ||| ...  |||||| ||.| .||..|. |. ||. .|||..   .|.     |   |
vtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklsslqern
subfamily_PTPN9_pd Subfamily PTPN9 321-588 8.7e-73 239.9 In-house 8-288 (297) alignment 
Range on Protein: 321-588
Range on HMM: 8-288/297.0
KYVAIMQaNRGIRleAEYKNVSNEQQ-FSWDAARKAANKKKNRYGNIVTYDHSRVVLERVNGDEDSDYINASFIHGFDgTPRSYIASQGPPPPTFEGFWR
.||  .. .||..   ||... ||.     .|... || .|||| ... ||..||||..|..|| ||||||.|. |.   ....|| ||| . |.. |||
ayvkekg.krGls..keyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGyk.qkkafiatqGplkktvsdfWr

MVWEQNSQSIVMLTNLVELGKTKCHKYWP---EKTETYGGVTVTLHQTEVFADYVIRTFILFREERAVRRMVRQFNFTVWPDKGVPQYATAVLAFRRKVR
|||||.   ||| | .|| |. || .|||   |... .| ..|.  ..|.  ||..|.. . . .    | |  | |. ||| |||. |...| ...|||
mvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvr

A--------LNPRDA-----GPVIVHCSAGVGRTGAYIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
         | ....      |..||||||.||||..| .|  |.. .   |||... .  ||. | ...|| ||| | . ||||
ekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
0043336 (Phosphotyrosine protein) phosphatases II 614-883 3e-72 238.7 In-house 15-277 (278) alignment 
Range on Protein: 614-883
Range on HMM: 15-277/278.0
RKFQMTGYALEFQRLNSFTSreipaEEKSVGEEPQNLQKNRFCDIVALNSCRVMLRKEHADEESDYINAVFLHAHRERNAFIATQHPLLETVEDFWRMVT
 .   |.. |||..|.||.      ...|... |.| .|||. ||......|| |  .  |. |||||| ..  ..  ..|||||.|| |||||||||| 
llnlktllllefeellsfkl.....dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvw

DYDIGTIVMLNNLHELD-QEYPQYWPdHGATKYGHIGVSVLSKQEKGDVISTKLEVTRkKVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQTSQQ
.... |||||..| ||. . . ||||  | ..||.. | .|. ....|.. ..||||. .   ....|.|.|...||| ..||   ..||.| .|.. ..
elgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtn.lgdgesrtvthyhylgwpdhgvpeslsllldflkavreale

qCGNAPVLVQCSNGVGRSGTFCVISSVIERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKYL
   | |||| ||.||||.|||...  ..|.|..|. .|.....|..|  |||||... ||.|.|.... ||
.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
Y_phosphatase Protein-tyrosine phosphatase 649-880 9e-72 236.6 Pfam-A 1-234 (235) alignment 
Range on Protein: 649-880
Range on HMM: 1-234/235.0
NLQKNRFCDIVALNSCRVMLrkEHADEESDYINAVFLHAHRERNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHEL-DQEYPQYWP--DHGATKY
|..|||. ||.. .. || |  .. ...|||||| ... ..| ..|||||.|| .|.|||||||..... .||||..| |  .....||||  ... ..|
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GHIGVSVL--SKQEKGDVISTKLEVTRKKVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQTSQqQCGNAPVLVQCSNGVGRSGTFCVISSVIERL
|.| | .   .|... ... .|||.. || .....||..||. .|||...|| . |.|||...|..|. .  ..||.|.||.||||.|||.... ..|.|
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

KTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQ
..|. .||.|..|..| .|||.|.||.||.|.|..|.
eaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 649-880 9e-72 236.6 In-house 1-234 (235) alignment 
Range on Protein: 649-880
Range on HMM: 1-234/235.0
NLQKNRFCDIVALNSCRVMLrkEHADEESDYINAVFLHAHRERNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHEL-DQEYPQYWP--DHGATKY
|..|||. ||.. .. || |  .. ...|||||| ... ..| ..|||||.|| .|.|||||||..... .||||..| |  .....||||  ... ..|
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GHIGVSVL--SKQEKGDVISTKLEVTRKKVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQTSQqQCGNAPVLVQCSNGVGRSGTFCVISSVIERL
|.| | .   .|... ... .|||.. || .....||..||. .|||...|| . |.|||...|..|. .  ..||.|.||.||||.|||.... ..|.|
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

KTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQ
..|. .||.|..|..| .|||.|.||.||.|.|..|.
eaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 616-880 4.1e-71 234.4 In-house 18-276 (288) alignment 
Range on Protein: 616-880
Range on HMM: 18-276/288.0
FQMTGYALEFQRLNSFTSreipAEEKSVGEEPQNLQKNRFCDIVALNSCRVMLRKEHADEESDYINAVFLHAHRERNAFIATQHPLLETVEDFWRMVTDY
 . ||.  |.. | .. .     .....|....| .|||. .|....  || |.| .  ...||||| ... .......|||| || .||.|||..| ..
rnrtgfseeynsLaalek....tksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyen

DIGTIVMLNNLHELD-QEYPQYWPDHGA-TKYGHIGVSVLSKQEKGDVISTKLEVTRKKVRRkthEVRHLHHVSWPDKCIPEVACSVLDLLDDVQTSQQQ
.. |||||..| | . ..  .|||| .  ..||.. | .....|..|..  ||.. .|| ..   |. .... .|||. .|| .  .|.||. |....|.
ktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkktel...eitqyqylaWpdhgvPeskapllellrqvkvanqa

CgNAPVLVQCSNGVGRSGTFCVISSVIERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQ
    |..|.||.||||.||| ..  .|.....|..|||. .....| .|.  |. |.||.|.|... 
d.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_PTPN3_pd Subfamily PTPN3 345-589 8.2e-71 233.2 In-house 29-274 (280) alignment 
Range on Protein: 345-589
Range on HMM: 29-274/280.0
QQFSWDAARKAANKKKNRYGNIVTYDHSRVVLErvngDEDSDYINASFIH-GFDG--TPRSYIASQGPPPPTFEGFWRMVWEQNSQSIVMLTNLVELGKT
.. . .||||..| .|||| .|..||. || |.    ....|||||...    ..  .   |||.||| . | . ||.|||||.|. |||||.||| |..
pglaisaarkpenlsknryrdilpydatrvklk....esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrv

KCHKYWPEKTE--TYGGVTVTLHQTEVFADYVIRTFILFREERAVRRMVRQFNFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGA
|||.||||...  .||. .|......    ||.| ..| ..|   .|.. |. .. |||.|||. .. .| | ..||.|   .  ||.||||||.|||| 
kChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGv

YIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
.|...  |    ... | . . .  .|  |  .|||..|| |.  |.|..
lilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
subfamily_Ptp69D_pd Subfamily Ptp69D 619-883 1.7e-70 232.6 In-house 22-286 (307) alignment 
Range on Protein: 619-883
Range on HMM: 22-286/307.0
TGYALEFQRLNSFtsrEIPaEEKSVGEEPQNLQKNRFCDIVALNSCRVMLRKEHADEESDYINAVFLHAHRERNAFIATQHPLLETVEDFWRMVTDYDIG
 |.| |...|..    ||.  . .|.|.  |. |||. ||.| .. ||.|.|   .|.|||||| |.....|.. ||| | |. .|..|||||... .. 
fglakeyekLear...eid.kstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevt

TIVMLNNLHELDQE-YPQYWPDHGATKYGHIGVSVLSKQEKGDVISTKLEVTRKKV----RRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQTSQQQ
.|||| || | ...  ..|||.   ..||.| | . |.....| |  .|.|..||       ....|   |. .|.|  .|||| ..|.|.. |.  ...
livmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykl

CgNAPVLVQCSNGVGRSGTFCVISSVIERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKYL
  ..|..| ||.||||||.|  ..|....||.|. .|.|...| .| .|.  |.|| ||||.|. . .| 
n.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldys
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 334-588 1.9e-70 232.1 In-house 7-266 (274) alignment 
Range on Protein: 334-588
Range on HMM: 7-266/274.0
LEAEYKNVSNEQqfSWDAARKAANKKKNRYGNIVTYDHSRVVLERVNGDE-DSDYINASFIHGFDGTPRSYIASQGPPPPTFEGFWRMVWEQNSQSIVML
||.|. ..  .   . .  . . ...|||| .|.  ..|||.||. .... ||.|||| .|.|.|.. . |.| ||| | | . ||||......| ||||
lekeflelPlnf..dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivml

TNLVELGKTKCHKYWPEKTET-----YGGVTVTLHQTEVFADYVIRTFILFREERavRRMVRQFNFTVWPDKGVPQYATAVLAFRRKVRALNPR---DAG
|.| |  ..||..|.|.....     ||.| .. ...    || .|...|   ||  .| |  . .| |||. .|. |...| . ..|.  . .    ..
tklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenakla

PVIVHCSAGVGRTGAYIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
||.||||||.||||..| |.  . | . . .||. .    || ||  ||||.||| .|| |. .
pvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl
subfamily_PTPRK_pd Subfamily PTPRK 643-879 2.2e-69 228.7 In-house 37-273 (314) alignment 
Range on Protein: 643-879
Range on HMM: 37-273/314.0
VGEEPQNLQKNRFCDIVALNSCRVMLRKEHADEESDYINAVFLHAHRERNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELD-QEYPQYWPDHG
.  . .| .|||. ||.| . .||.|   . | .|||||| .. ...  .|||.||.|| |||.||||.| |..  .||||..| |    .  .|||...
aakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedt

ATkYGHIGVSVLSKQEKGDVISTKLEVTR-KKVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQTSQQQcGNAPVLVQCSNGVGRSGTFCVISSVI
 . ||.| | ... . . ....  . |.. ..   ...|||......|||  .|  | ..|.|.  |..||.. .. ...| ||.| ||.|||..|..|.
ev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivl

ERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQII
. ...|.|.|||...| .| ...  ||   ||.|.|..|
dmieregvvdvfnavktlrsrkvnmveteeqykfiydvi
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 314-594 3.2e-69 228.0 In-house 2-287 (290) alignment 
Range on Protein: 314-594
Range on HMM: 2-287/290.0
ISVAHFPKYVAIMQANRGIRLEAEYKNV-SNEQQFSWDAARKAANKKKNRYGNIVTYDHSRVVLERVNGDED--SDYINASFIHGFDGTpRSYIASQGPP
| | .| ..||  .|.   . ....| . | |....   .    ||..||. ||| ||  |..| ...|..|   .||||..|.|.    ..||| ||| 
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykek.kqyiatqgpv

PPTFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPEK-TETYGGVTVTLHQTEVFADYVIRTFILFREER-AVRRMVRQFNFTVWPDKG-VPQYATA
. |   ||...|....  |||||| .| ||.||..|||.. |..|| ....|.. |.. .|..|.. .  ..  . ...| |...| |...| |....| 
sntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqti

VLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGN
.|.... ..    |  ....||||..|||.. .....  ....|..  .|. . |  .|  .| .|||..|| .|.. ||..|.. .
llvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfe
subfamily_PTPN13_pd Subfamily PTPN13 336-591 2.9e-68 225.1 In-house 15-270 (273) alignment 
Range on Protein: 336-591
Range on HMM: 15-270/273.0
AEYKNVSNEQ-QFSWDAARKAANKKKNRYGNIVTYDHSRVVLERVNGdedsdYINASFIHGFDGT-PRSYIASQGPPPPTFEGFWRMVWEQNSQSIVMLT
 |.|.. . . . . . ..|..||.|||| |.. ||..|| |.   |     |||||.|.   |    .|||.||| | | . ||.|||||... |.|.|
eefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvt

NLVELGKTKCHKYWPEKTE----TYGGVTVTLHQTEVFADYVIRTFILFREERAVRRMVRQFNFTVWPDKGVPQYATAVLAFRRKVRALNPrDAGPVIVH
. .| || |||.||||...     .. ..|.| ...   ..|.|.. .   | .  | | ..||. ||| |||. |. .| | ..|| |.  ||||..||
lekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvh

CSAGVGRTGAYIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALT
||||.||.|..|.||..|.  . .. .|... .  ||. |  .||||.|| |.. |.||.|.
csaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
0040439 (Phosphotyrosine protein) phosphatases II 642-883 4e-68 225.0 In-house 4-246 (249) alignment 
Range on Protein: 642-883
Range on HMM: 4-246/249.0
SVGEEPQNLQKNRFCDIVALNSCRVMLRKEHADEESDYINAVFLHAHRERNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHEL-DQEYPQYWPDH
||.. | |. |||. ||......|| |      . |||||| ...  .  ..|||||.|| |||||||||. ...|..||||..| ||  . . ||||. 
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplg

GATKYGHIGVSVLSKQEKGDVISTKLEVTRKkVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQTSQQQC-GNAPVLVQCSNGVGRSGTFCVISSV
| ..||.. | .|| ..|.|.. ..||.|..    ....|.|.....|||  .|.   ..||... |.. ....  . |||| ||.||||.|||...  .
gsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylm

IERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKYL
.|.|..|. .|.....| .|  |||||... ||.|.|......|
leqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0042113 (Phosphotyrosine protein) phosphatases II 642-883 8.5e-68 223.7 In-house 2-243 (245) alignment 
Range on Protein: 642-883
Range on HMM: 2-243/245.0
SVGEEPQNLQKNRFCDIVALNSCRVMLRKEHADEESDYINAVFLHAHRERNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQE-YPQYWPDH
||.. | | .|||. ||......|| |  .  |. |||||| . . .|  . |||||.|| |||||||||. ...| |||||....||... ..||||..
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

GATKYGHIGVSVLSKQEKGDVISTKLEVTRkKVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQTSQQQCGNAPVLVQCSNGVGRSGTFCVISSVI
. ..||.. | .|| . ..|.. ..||||. .   ...||.|.|...||| ..|.   ..||.|. |.. .....| |||| || ||||.|||...  ..
esltygdftvtllseehlddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylml

ERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKYL
|.|..|. .......|..|  |||||... ||.|.|......|
eqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 312-613 1e-67 223.3 In-house 2-259 (392) alignment 
Range on Protein: 312-613
Range on HMM: 2-259/392.0
KPISVAHFPKYVAimQANRGIRLEAEYKNVSNEQQFSWDAARKAANKKKNRYGNIVTYDHSRVVLERVNGDEDSDYINASFIHGFDGTpRSYIASQGPPP
.|| ||.|| .|   .  .   .  |.... . . .   .|.|  |.|||||.||. || .||.|| ..   ||||.|||.|..||   ..||||||| .
qpipvaqfpafve..knrhsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdne.kayiasqgpna

PTFEGFWRMVWEQNSQSIVMLTNLVELGktkchkywpektetyggvtvtlhqtevfadyvirtfilfreERAVRRMVRQFNFTVWPDKGVPQYATAVLAF
 ... |||||...|  .|.|.|.| |                                                | | || || ||||.||......| |
aslddfwrmvfqenvttiamvtklkegd.........................................kgddartvaqfhftewPdkdvpkhtssllkf

RRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENFNQTTQKLAS
 ..|.|   . . |.|.||||||||||  | ||... .||  | ||. |..  .|. ||.||||||||.||. |||| |   || |    | .  |.| .
ikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlst

VN
  
ss
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 316-597 1.2e-67 222.9 In-house 4-285 (287) alignment 
Range on Protein: 316-597
Range on HMM: 4-285/287.0
VAHFPKYVAIMQANRGIRLEAEYKNVSN--EQQFSWDAARKAANKKKNRYGNIVTYDHSRVVLErvngDEDSDYINASFIHGFDGTpRSYIASQGPPPPT
| .| ..||  .|.     .  .. . .  ... .   .    ||.|||. .|. .|  ||.|.    .|. |||||.|| |.    . .|....|   |
vekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykek.kafiiaesPmfnt

FEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPEKT-ETYGGVTVTLHQTEVFADYVIRTFILFREE-RAVRRMVRQFNFTVWPDKG-VPQYATAVLA
   ||......| . ||||... |  . .|..||||..  ..|  ...| . || |.|..|.. . ...  . ...|.|...| |...| |....| .| 
arnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillv

FRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEI
. .....   |  ....||||..|||.. .. ..  ....| . ..|. . |   |  .|..||| ||| ||  .||| |....|  
ieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetys
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 614-892 2.3e-67 222.0 In-house 15-287 (287) alignment 
Range on Protein: 614-892
Range on HMM: 15-287/287.0
RKFQMTGYALEFQRLNSFTSREipaEEKSVGEEPQNLQKNRFCDIVALNSCRVMLRkehaDEESDYINAVFLHAHRERNAFIATQHPLLETVEDFWRMVT
..   .|.   |. |.. | ||   .|  ..  .|| .|||. .|.  .  ||.|.    .|. |||||||. ...|..|||... |. .|. .||... 
hakgnegfknqftvleqvtqre...devthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWklid

DYDIGTIVMLNNLHELDQEY-PQYWPDHGATKYGHIGVSVLSKQEKGDVISTKLEVTRKKVRRKTHEVRHLHHVSWPDKC-IPEVACSVLDLlDDVQTSQ
|  . .|||| ...| |.|   ||||.. .. .|.  ...|... . ..|  ||||..|.   ....|.  .  .|...  ..| . ..| . ..   .|
drnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvi.eemyktq

QQCGNAPVLVQCSNGVGRSGTFCVISSVIERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKYLGSFSDYANF
.. ||....| ||..||||..|| .   |.. ||| |||||||.|. |. .||.|   .|| | ..|...|| ||. |..|
rkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysdf
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 338-588 4.4e-67 220.9 In-house 1-262 (270) alignment 
Range on Protein: 338-588
Range on HMM: 1-262/270.0
YKNVSNEQQFSWDAARKAANKKKNRYGNIVTYDHSRVVLERVNGDEDSDYINASFIHGFDGTPRSYIASQGPPPPTFEGFWRMVWEQNSQSIVMLTNLVE
.|....|.. . |    | .|| ||| .|.   ..||.||... |. . |||| ...|||| ...|||..|| | | . ||||.||.....|||.|.|.|
fkeldkeetsesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleE

LGKTKCHKYWPEKTET-----YGGVTVtLHQTEVFADYVIRTFILFREERAVRRMVrQFNFTVWPDKGVPQYAT------AVLAFRRKVRALNPRD--AG
 |..|| .|||.....     .| ..| | ..|. ..  |.| .  .|.   ||.|  | .. |||.|||. .        .|.  |.||. . .   |.
kgrkkCerYWpaepkekvkledgkikv.lalseekeegyiltrlrleekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae

PVIVHCSAGVGRTGAYIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
|..|||||||||||  |..| ...  . .. ||. . . .|||||. .||. ||| |.. ||.|
PllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 612-889 4.5e-67 220.9 In-house 13-289 (290) alignment 
Range on Protein: 612-889
Range on HMM: 13-289/290.0
VNRKFQMTGYALEFQRLNSFTSReipaEEKSVGEEPQNLQKNRFCDIVALNSCRVMLR--KEHADEESDYINAVFLHAHRERNAFIATQHPLLETVEDFW
 ... ...|.  .|..|.|. |     ..  ||  ..| ..||| .||  .  |..||   .| | . .||||.... ..|....|||| |. .|. |||
nghakgnegfrnqfkmldsgese....htvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFW

RMVTDYDIGTIVMLNNLHELDQE-YPQYWPDHGATKYGHIGVSVLSKQEKGDVISTKLEVTRKKVRRKTHEVRHLHHVSWPDKC-IPEVAcSVLDLLDDV
... . ..  |||| |  | ...   |||||.....||.. . .|. ..  . | .||||. |.   ....| ...  .|...  ... . ..| ..  .
kliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpq.tillvieem

QTSQQQCGNAPVLVQCSNGVGRSGTFCVISSVIERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKYLGSFSDY
.  | . || ...| ||..||||..||..   |.. |||.|||||||.|. |. .|| |..  || . .||. .|| ||. |
yktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 352-604 1.2e-66 220.0 In-house 41-293 (439) alignment 
Range on Protein: 352-604
Range on HMM: 41-293/439.0
AR--KAANKKKNRYGNIVTYDHSRVVLERVNGDEDSDYINASFIHGFDgTPRSYIASQGPPPPTFEGFWRMVWEQNSQSIVMLTNLVELGKtkchkYWPE
.   .  .. |||| .....||.||.|. . |   | |||| .|.|.  ... |||.|||   | . |||.|.|...  |||||||||  |     ||| 
slaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyy.ddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywps

KTETY-GGVTVTLHQTEVFADYVIRTFILFREE--RAVRRMVRQFNFTVWPDKGVPQYATAVLAFRRKVRALNP-RDAGPVIVHCSAGVGRTGAYIVIDA
..|.. | ..|   .   . .|||| | .| |       | | || .. |||| ||  |. || | | . . |  .. |||.|||||||||||. | .| 
daevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdi

MLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENFNQ
 ||| |..  |||.  .  |||.| .|||.  || ||. |||| .  |.. .. ..|..
aleqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefkk
subfamily_PTPN1_pd Subfamily PTPN1 337-596 5.3e-66 217.3 In-house 11-279 (290) alignment 
Range on Protein: 337-596
Range on HMM: 11-279/290.0
EYKNVSNEQ-QFSWDAARKAANKKKNRYGNIVTYDHSRVVLERvngdEDSDYINASFIHgFDGTPRSYIASQGPPPPTFEGFWRMVWEQNSQSIVMLTNL
 |.....|  .|.  .|.. .|...||| ..  |||||..|||    .| ||||||... ..   |||| .||| | | . ||.|||||.|...||| ..
iyldirkeasdfptreaklpenrnlnryrdvspydhsrikler....adndyinaslve.leeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkv

VELGKTKCHKYWPEKTE----TYG--GVTVTLHQTEVFADYVIRTFILFREERAVRRMVRQFNFTVWPDKGVPQYATAVLAFRRKVRAL--NPRDAGPVI
|| ...||..|||.. |    ..    ..|.| ..|.   |..|.. |   .    | . .| .| ||| |||.  .| | |  |||      .| ||..
vekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpav

VHCSAGVGRTGAYIVIDAMLEQAK---INRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTC--GNTE
.|||||.||.|.....|..| . .      .|||.. |..||| |  ..||..|  | . |.||   .  |.. 
ihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdss
subfamily_CG7180_pd Subfamily CG7180 320-594 5.4e-66 217.2 In-house 6-294 (296) alignment 
Range on Protein: 320-594
Range on HMM: 6-294/296.0
PKYVAIMQANRgIRLEAEYKNVSNEQQFSWDAARKAANKKKNRYGNIVTYDHSRVVLERVNGDEDSDYINASFIHGFDgTPRSYIASQGPPPPTFEGFWR
 |.|  ..  | .  . |.| ... ..    .. .. |..|||. ..| ||. |||||...|.|.||||||... .|   .. ||  ..|   | . |||
lklvdkrrkfr.veyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsfl.kkkeyivteapkketvdefWr

MVWEQNSQSIVMLTNLVELGKtKCHKYWPEK-TETYGGVTVTLHQTEVFADYVIRTFILFRE----------ERAVRRMVRQFNFTVWPD-KGVPQYATA
.|........|.||.  .  | ....|||.|  | || . | . ... .|. .|||| | ..          . |  |.|..|..|.|.  . ||  ..|
lvydeeisavvvLtktfdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstna

VLAFRRKVRALNPRD-----AGPVIVHCSAGVGRTGAYIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGN
.. .||.|| .  .       |||.|..| |..|.|.|. ||| ||.....  ||. ...  ||..||..|...|.| .|   .|||. |. 
lielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk
subfamily_PTPRN_pd Subfamily PTPRN 333-589 1.5e-65 215.8 In-house 30-291 (297) alignment 
Range on Protein: 333-589
Range on HMM: 30-291/297.0
RLEAEYKNVSNE--QQFSWDAARKAANKKKNRYGNIVTYDHSRVVLERVNGDEDSDYINASFIHGFDGTPRSYIASQGPPPPTFEGFWRMVWEQNSQSIV
|||.|.. . .   .. . ..|..  | ||||. ....|||||| |.. . .|.|||||||.|   |    .|||.||| . |   ||.||||| .  ||
rlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvviv

MLTNLVELGKTKCHKYWPEK-TETYGGVTVTLHQTEVFA-DYVIRTFILFREERAVRRMVRQFNFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIV
.||.| | | ..|..|||.. .|.|.   | |    ... ||..|.| |   .    | | || |  ||..|||  | ..| |||||       . |..|
nltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivv

HCSAGVGRTGAYIVIDAMLEQ-AKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
|||.|.||||.||.|| .|.. .|  . .||   |  || .||..|.||.|. |. .|| | 
hcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaee
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 641-885 2.6e-65 215.5 In-house 43-286 (297) alignment 
Range on Protein: 641-885
Range on HMM: 43-286/297.0
KSVGEEPQNLQKNRFCDIVALNSCRVMLRKEHADEESDYINAVFLHAHRErnAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQEYPQYWPDH
. | |.  |..|.|. .|.  .| ||.|.    | .|||.|| |... ..   .|.|| |  .||.|||.|| |... ||||||...| |..  .||.|.
qtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdk

GATKYGHIGVSVLSKQEKGDVISTKLEVTRKKVrRKTHEVRHLHHVSWPDKCIPE--VACSVLDLLDDVQTSQQQCGNAPVLVQCSNGVGRSGTFCVISS
| |..|.. | .|| .|.   |  .||||. |  .... |.  ..|.|||| ...   | |.|.|...|. . .|  ..|.|| |..|||| | .. | |
gvttfGdvsvvllsvsereGfikrelevtkgka.karrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltids

VIERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKYLGS
|. . | |. .|.|...|..| .||  |    || | |... ..| |
vvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlealls
0045098 (Phosphotyrosine protein) phosphatases II 638-884 1.1e-64 213.8 In-house 22-273 (278) alignment 
Range on Protein: 638-884
Range on HMM: 22-273/278.0
AEEKSVGEEPQNLQKNRFCDIVALNSCRVMlrkehadeesDYINAVFLHAHreRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHEL-DQEYPQY
  | ...  . || |||. ||......||           ||||| ... .  ...|||||.|| .||.|||||. ...| .||||..|.||  . ..||
pseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqy

WPDHGATKYGHIGVSVLSKQEKGDVISTKLEVTRK---KVRRKTHEVRHLHHVSWPDKCIPEVA--CSVLDLLDDVQTSQQ------------QCGNAPV
||..|   ||.. | .|| .. .|.. ..|.||     .   ....|.||| ..||| ..|.     |.|.||. ..  ..            . .. ||
wpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpv

LVQCSNGVGRSGTFCVISSVIERLktEQVIDVFQVIKRIRVNRPG-AVESLTQYVFCYQIIQKYLG
|| || ||||.||....  ..|.|  |...|.....| .|  ||| ||..| ||.|.|. ....| 
lVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_PTPRB_pd Subfamily PTPRB 595-883 1.6e-63 209.4 In-house 5-285 (293) alignment 
Range on Protein: 595-883
Range on HMM: 5-285/293.0
TEIQSENFNQTTQKLASVNrKfqmTGYALEFQRLNSFTSREipaeEKSVGEEPQNLQKNRFCDIVALNSCRVMLRKEHADEESDYINAVFLHAHRERNAF
..|. |.|..  .|... . .   .... |...|... . .    .... |...| .|||. .|.. .  || | . . ...|||||| ... .. .. |
kpiklekfeehvkkmkads.d...lrfseeyeelkavgkdq....avkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynspref

IATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ-EYPQYWPDH-GATKYGHIGVSVLSKQEKGDVISTKLEVTRkkvRRKTHEVRHLHHVSWPDKC
|||| || |||.|||||| .    .|||| .| |  .    .|||..  .. ||.| |......|. | .  .|....   ......||..|..||||  
iatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhg

IPEVACSVLDLLDDVQTSQ-QQCGNAPVLVQCSNGVGRSGTFCVISSVIERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKYL
.|| . ..||..  |.... ... ..|..| || ||||.|||  .  .......|...|.| .. ..| .|   | . .||.| .| ....|
vPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll
subfamily_PTPRG_pd Subfamily PTPRG 619-884 1.6e-63 209.8 In-house 19-288 (563) alignment 
Range on Protein: 619-884
Range on HMM: 19-288/563.0
TGYALEFQRL-NSFTSREIPAEEksvGEEPQNLQKNRFCDIVALNSCRVMLRKEHADEES-DYINAVFLHAHRERNAFIATQHPLLETVEDFWRMVTDYD
.|.. ||. | .  .|....||     ..|.| .||| ..||| .. || |..    ... ||||| ... ..  .||||||.|| .|..|||||. .  
igfseefealqsetiskdldaeh...sqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqn

IGTIVMLNNLHEL-DQEYPQYWPDHGATKYGHIGVSVLSKQEKGDVISTKLEVTRKKVRRK-----THEVRHLHHVSWPDKCIPEVACSVLDLLDDVQTS
  .|||. || |   .. ..|||  .. .||.. |   ... .    . .| .   |...|      ..||. |  .|||.. || .  ||      ...
vaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaa

QQQcGNAPVLVQCSNGVGRSGTFCVISSVIERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKYLG
...    |..| ||.||||.||..|..........|....||...|.|| .|.  |..  ||.| ...... . 
nka.eaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaia
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 644-879 5.7e-63 207.7 In-house 44-275 (315) alignment 
Range on Protein: 644-879
Range on HMM: 44-275/315.0
GEEPQNLQKNRFCDIVALNSCRVMLRKEHADEESDYINAVFLHAHRERNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQEYPQ-YWPDHgA
  . .| ||||. .|.| .  || |     |..|||.|| |.  .  .. .||.| |. ..|.||||.| ..|||.||||.|| | ...  . ||||.  
akkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.k

TKYGHIGVSVLSKQEKGDVISTKLEVTRKkvrRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQTSQQQCGnAPVLVQCSNGVGRSGTFCVISSVIER
  ||.| |.  |.. . ..    | |. .    . .||  ||. ||||  .|. . ....|   |.  ...   ....| ||.||||.|||. ...|...
viyGkitvtrkseevnteytvrtlsvvfg...dnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavldq

LKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQII
...|..|||...|...| || ..|... || | |...
aeaenaidvynfitgvrqnrikmvqvaeqyqfiydal
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 619-883 6.5e-63 207.8 In-house 23-288 (325) alignment 
Range on Protein: 619-883
Range on HMM: 23-288/325.0
TGYALEFQRLNSFTsreipAEEKSVGEEPQNLQKNRFCDIVALNSCRVMLRKEHADEESDYINAVFLHAHRERNAFIATQHPLLETVEDFWRMVTDYDIG
 |.| ||. | |       .  | |   |.| .|||| ..|||.  ||.|   . | .|||||| .|. ..... |.|.| || .|..|.||.| |.   
dgfahefgllpsdd.....giakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcs

TIVMLNNLHELDQEYPQYWPDH--GATKYGHIGVSVLSKQEKGDVISTKLEVTRKKvRRKTHEVRHLHHVSWPDKCIPEVACSV---LDLLDDVQTSQQQ
 .|.|| | . ...  .|||..   . ..| . |.. . .|  | .  .|.| . | . .|  |. ... ||.|   ..  ...   |.|.. |.   . 
vvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvk.kGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservta

--CGNAPVLVQCSNGVGRSGTFCVISSVIERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKYL
   . .|.|| ||.||||.|.|  . |..... .|  .|.|...|..| .||  ||.  ||...|. . ...
ntkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_PTPN12_pd Subfamily PTPN12 619-883 4.5e-62 204.6 In-house 8-277 (290) alignment 
Range on Protein: 619-883
Range on HMM: 8-277/290.0
TGYALEFQRLNSFTSREIPAE--EKSVGEEPQNLQKNRFCDIVALNSCRVMLRKEHADEESDYINAVFLHAHRERNAFIATQHPLLETVEDFWRMVTDYD
  .| |||.| . ...    .  ....||...| .|||. ||.  .  ||.|.|.. .|.|||||| |..   .. ..||.| || .|..|||||. ...
eefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiwekn

IGTIVMLNNLHELDQEY-PQYWPDHGAT--KYGHIGVSVLSKQEKG-DVISTKLEVTRKkvrRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQTSQQ
.  .||. .. ||..    .|||..| .  ..|.. |.. ...    | .   |.|...   .....|. .|. .|||. .|. | |.|.|...|.. |.
veivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe

qCGNAPVLVQCSNGVGRSGTFCVISSVIERLKTEQV---IDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKYL
   .||..| || |||| || ..|  | | ||.|..   .|||... ..| .|. .| .  ||.. |. . ...
.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
0037934 (Phosphotyrosine protein) phosphatases II 644-883 5.9e-61 201.4 In-house 5-242 (243) alignment 
Range on Protein: 644-883
Range on HMM: 5-242/243.0
GEEPQNLQKNRFCDIVALNSCRVMLrkehadEESDYINAVFLHAHrERnaFIATQHPLLETVED----FWRMVTDYDIGTIVMLNNLHEL-DQEYPQYWP
.  |.|| |||..||....  || |      | |||||| .     .|  .||||.|| |||||    ||||. ...|..||||..| ||  . ..||||
allpenlsknrysdilpydhsrvkl......egsdyinanliyvt.pr..liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

dhGATKYGHIGVSVLSKQEKGDVISTKLEVTRKKVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQTSQQQ-------CGNAPVLVQCSNGVGRSG
  | . ||.. | .|| ....|.. ..|......    |..|.|.|...||| ..|.   ..||.||.|.. ...        .. |||| || ||||.|
..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtG

TFCVISSVIERLkteQvIDVFQVIKRIRVNRPG-AVESLTQYVFCYQIIQKYL
|....  ....|   . .|.....|..|  ||| ||... ||.|.|......|
tliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 614-890 1.1e-60 200.6 In-house 27-299 (319) alignment 
Range on Protein: 614-890
Range on HMM: 27-299/319.0
RKF--QMTGYALEFQRLnsfTSREIPAEEKSVGEEPQNLQKNRFCDIVALNSCRVMLRKEHADEESDYINAVFLHAHRERNAFIATQHPLLETVEDFWRM
..|  ..| .  ||.|.   . . ..  ...  . .||  |||. .|.| .  .| |..    | |||||| |.  .. .. .||.| || .|..|||||
sdfdddltklevefrra...cklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrm

VTDYDIGTIVMLNnlhelDQEYPQYWPDHGATKYGHIGVSVLSKQEKGDVISTKLEVTRKKVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQ-TS
. .|.. |||.|       .   |||| ..  |...  |.| | .|  . .  ..|....   .   ...  |   |||.  |. .  .. |.. |.   
iweyncstivllt.....kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhlt

QQQCGNAPVLVQCSNGVGRSGTFCVISSVIERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQ-KYLGSFSDYA
... ..|...| || ||||.|.. |.  ...|.| |. .||..... .| .|.  |..|.|| |.|  .  ..| ..|| |
skenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdva
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 636-883 1.1e-60 200.1 In-house 31-277 (315) alignment 
Range on Protein: 636-883
Range on HMM: 31-277/315.0
IPAEEKSVGEEPQNLQKNRFCDIVALNSCRVMLRKEHADEESDYINAVFLHAHRERNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ-EYP
 .. .. |. |..| .|||. .|. |.| ||.|     . .|||||| ....  . .|.||.| ||  .|.|||||| .... ||||.....| |. .  
PdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcr

QYWPD--HGATKYGHIGVSVLSKQEKGDVISTKLeVTRKKvrRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQTSqQQCGNAPVLVQCSNGVGRSGT
|||||    ....| | |..|| .  .| .  || ||||    ... |   .   |||| ... . |.| |. .|... ..  . ..|| || ||||.| 
qywPdrkadsvefGsikvellsleadtdgvarkl.vtrks..eesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGv

FCVISSVIERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKYL
.. | .|....| ....|||...| .| .||  | .  .| | |......|
visidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledl
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 634-890 1.3e-59 197.0 In-house 10-263 (284) alignment 
Range on Protein: 634-890
Range on HMM: 10-263/284.0
REIPAEEKSVGEEPQNLQKNRFCDIVALNSCRVMLRKEHADEESDYINAVFLHAHRERNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNnlhelDQEY
. ... ...  . .||  |||. .|.| .  .| |..    | |||||| |.  .. .. .|||| || .|..|||||. .|.. |||.|      ..  
lgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.....kdkc

PQYWPDHGATKYGHIGVSVLSKQEKGDVISTKLEVTRKKVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQ-TSQQQCGNAPVLVQCSNGVGRSGT
 |||| ..  |...  |.| | .|  . .  ..|....   ..  ..|  |   |||.  |. .  .. |.. |.  .... ..|...| || ||||.|.
sqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgv

FCVISSVIERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQ-KYLGSFSDYA
. |.  ...|.| |. .||..... .| .|.  |..|.|| |.|  .  ..| ..|| |
yivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdva
subfamily_PTPN6_pd Subfamily PTPN6 595-884 4.2e-59 195.0 In-house 2-298 (306) alignment 
Range on Protein: 595-884
Range on HMM: 2-298/306.0
TEIQSENFNQTTQKLASVNRKFQMTGYALEFQRLNSFTSREIpaEEKSVGEEPQNLQKNRFCDIVALNSCRVMLRkEHADEESDYINAVFLH--AHRERN
|.. ... .|  ..|   . ... .|.  ||..|.   ...    ... |. |.| .|||.  |.  .  ||.|. |.   .|||||| ...  .. ...
tsllakeieqrvselekeeeslekagfeeefeelqqeeakkl..lsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdk

AFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ-EYPQYWPDHGAT-KYGHIGVSVLSKQEKGDVISTKLEVTRKKVRRKTHEVRHLHHVSWPD
..||||  | .||.|||||| . .   |||. .  |  .    .||||. .. .||.| |. .|.... | |  .| |..||  ....||...|. ||||
syiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPd

KCIPEVACSVLDLLDDVQTSQQQCG---NAPVLVQCSNGVGRSGTFCVISSVIERLKT---EQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKYLG
. .|.    |||.|.||.. |...    . |..| ||.|.|| ||| ||  ... ...   .  ||. ...| .|  | | |   .|| | |..|.||. 
hgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyie
subfamily_PTPN23_pd Subfamily PTPN23 338-589 4.3e-59 194.7 In-house 21-279 (288) alignment 
Range on Protein: 338-589
Range on HMM: 21-279/288.0
YKNVS-----NEQQFSWDAARKaaNKKKNRYGNIVTYDHSRVVLErvngDEDSDYINASFIHGFDGTPRSYIASQGPPPPTFEGFWRMVWEQNSQSIVML
.|..      . ...|  .|..  . .|||. .|. |||.||.|.    ..  |||||||...   .  ..||.|.| ..|   ||.||.|| |. ||||
fkeleqkqdkearkrsiaiakl..yseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVml

TNLVELGKTKCHKYWPEK---TETYGGVTVTLHQTEVFADYVIRTFILFREERAVRRMVRQFNFTVWPDKGVPQYATAVLAFRRKVRA----LNPRDAGP
..  ||||.|...||||.   |...| ..|||....    .| |...|  ..    ..|.  ..| ||. |||.    .|.|  .|..     . .   |
lskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktP

VIVHCSAGVGRTGAYIVI-DAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
..|||||||||||.. ..  |. |  | |  .|| . .  ||..| .|||.|||. |  .|||||
lvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 642-883 9.9e-59 193.8 In-house 36-276 (515) alignment 
Range on Protein: 642-883
Range on HMM: 36-276/515.0
SVGEEPQNLQKNRFCDIVALNSCRVMLRKEHADEESDYINAVFLHAHRERNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQE-YPQYWPD-
.| .|  | .|||. .|. ..| || |   . . .|||.|| ....    .|.||.| |.  .|.||||.| .... ||.|...|.| |.    .|||| 
tvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdk

-HGATKYGHIGVSVLSKQEKGDVISTKLEVTRKKvrrKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQTSQQQCGnAPVLVQCSNGVGRSGTFCVISS
   . |.|.| |...| .  .. |  ||.|.. .   ... |   |   |||| .|. . |.| |. .|.....|    |... || |||| | .. | |
pgdsvkfGsikvelvsleactggikrkltvlkgd...dsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtGvvisids

VIERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKYL
|. . || ...|||.... || .||  |    || | |.... .|
vvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 614-883 1.9e-58 192.8 In-house 10-276 (281) alignment 
Range on Protein: 614-883
Range on HMM: 10-276/281.0
RKFQMTGYALEFQRLNSFTSREiPAeekSVGEEPQNLQKNRFCDIVALNSCRVMLRKEHADEESDYINAVFLHAHRERNAFIATQHPLLETVEDFWRMVT
.. . .|.. |.. |..   .. .|   .  ....| .|||. .||| .  || . ........||||| |. . .. ...|||| |. .....||.|| 
sqndnaGfieeyeklaaigvdn.ta...taskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvw

DYDIGTIVMLNNLHELDQ-EYPQYWPDHG-ATKYGHIGVSVLSKQEKGDVISTKLEVTRKKvrRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQTSQ
.... .|||. .  | ..    .||||.  ..|||.. |. ....||   |. |....|..   .| ||..|....|||. .|. .  .|.  ..|.  .
eqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleres..getreveqlaytaWPdhGvPattkellefrkevlklt

QQCGNAPVLVQCSNGVGRSGTFCVISSVIERLKTE-QVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKYL
..  .||... || ||||.||.  .  .......| . .|| .|.. .| .|   | ...|| | |... ..|
ekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 324-596 2.9e-58 191.9 In-house 10-299 (301) alignment 
Range on Protein: 324-596
Range on HMM: 10-299/301.0
AIMQANRgirLEAEYKNVSNEQQFSWDAARKAANKKKNRYGNIVTYDHSRVVLERVNG--DEDSDYINASFIHGFDGTpRSYIASQGPPPPTFEGFWRMV
|....|.   .|..||....... | .   . .||. ||. ||..||. |..|.  .       .|||||.|.|.  . . .||.|||   |   |||..
aakhsnk...feeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysek.kkfiaaqgpmkktlvdfWrli

WEQNSQSIVMLTNLVELGKTKCHKYWPE---KTETYGGVTVTLHQTEVFADYVIRTFILFREE--------------R-AVRRMVRQFNFTVWPDKGV-P
|..  .||||.||| |  |.||..|||.   ..|..| .||||... |. |.||| . .  ..              .    . | |.. | ||. || .
wqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvr

QYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTE
...| . .    . . .  . |||.||||..|.|.| |. ..  |||.| .  ||. .   |.|. .| .|.| |||..|. .. . |.. .|.
eprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnsty
subfamily_PTPN9_pd Subfamily PTPN9 641-882 4.5e-58 191.6 In-house 34-289 (297) alignment 
Range on Protein: 641-882
Range on HMM: 34-289/297.0
KSVGEEPQNLQKNRFCDIVALNSCRVMLRKEHADEESDYINAVFLHAHRERNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ-EYPQYWP-
  . . . ||.|||. |.. ... ||.| |.. ||.|||||| |.  .....|||||| || .||.|||||| . .. .|||   . |  .    |||| 
flasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpl

-DHGATKYGHIGVSVLSKQEKGDVISTKLEVTRKKVrRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQTSQQ------------QCGNAPVLVQCSN
 .. ....|.. ||... .|. |   ..||... |  ... .| |   .||||  .|. | |.||.|. |.  |             .. . |..| || 
eeessaefgdlsvsnveveeeedykvrvleiknvkt.eesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsa

GVGRSGTFCVISSVIERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKY
|.||.|||. .   ..||......||....|..|  |  ..    ||.|||. .  |
GiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 339-587 2e-57 189.2 In-house 20-274 (287) alignment 
Range on Protein: 339-587
Range on HMM: 20-274/287.0
KNVSNEQQFSWDAARKAANKKKNRYGNIVTYDHSRVVLErVNGDEDSDYINASFIHGFDGTpRSYIASQGPPPPTFEGFWRMVWEQNSQSIVMLTNLVEL
|. |.   . . || . |. |||||.... .|..||.|   .|.  |||||| .. ..     ..||.||| . |   |||.|.|..| |....|  || 
kedsesstatfkaaeelaavkknryadvlPiddtrvlls.aegelGsdyinanyvasytdd.eafiaaqgPiaatvrdfwravletrsasvitmtrevee

GKTKCHKYWPEKTE--TYGGVTVT-LHQTEVFADYVIRTFILFREERAVRRMVRQFNFTVWPDKGVPQYATAVLAFRRKV-----RALNPRDAGPVIVHC
.. ||.|||||.      || .|. | ..    .| .|.. |   |    |.|.|...  ||||...  | ... |  .|      | .  ..||..||.
arlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhd

SAGVGRTGAYIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVL
..|.||.| .. . ..... .    ||. . .| ||. |  .||.  |. ..  |. 
dvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_PTPRD_pd Subfamily PTPRD 732-890 2.8e-57 189.7 In-house 132-288 (564) alignment 
Range on Protein: 732-890
Range on HMM: 132-288/564.0
EYPQYWPDHGATKYGHIGVSVLSKQEKGDVISTKLEVtRKKVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQTSQqQCGNAPVLVQCSNGVGRSG
.. .|||..| ..||.. |.. ...|. |.. ..... .|| .....|||. |..||||...|| |.|.|||...|.... .... |..|.||.||||.|
kchkYWPekgtetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTG

TFCVISSVIERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKYLGSFSDYA
||.||....||.|.|...|..|..|..| .|.  |.. .||.|....|...| ....  
tfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntev
subfamily_PTPN14_pd Subfamily PTPN14 336-590 3e-57 188.9 In-house 27-296 (300) alignment 
Range on Protein: 336-590
Range on HMM: 27-296/300.0
AEYKNVSNEQ-QFSWDAARKAANKKKNRYGNIVTYDHSRVVLERVNgDEDSDYINASFIHG-FDGTPRSYIASQGPPPPTFEGFWRMVWEQNSQSIVMLT
.|| ...... .   ..|.   |..|||. ... |...|| |   . .....||||| |.    |. ||||..||| . | . ||.|||||. | |||||
teyeripkkredallstaklpenaeknrfkdvlPyednrvelsptk.enstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlt

NLVELGKTKCHKYWPEK-----TETYGGVTVTLHQTEVFADYVIRTFILFREERAVRRMVRQFNFTVWPDKGVPQYATAVLAFRRKVRALNPR-------
.  | ||.|..||.|..     | ..|   || . .|    .. ... |       .| |  . .| |||.|||.  .  | . ..|...  .       
eeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseves

--DAGPVIVHCSAGVGRTGAYIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
     ||.|||||||||||  |. | ...  . |...||.. |  ||. | ..|||  || |....... |
keskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 647-884 3.9e-56 185.1 In-house 26-269 (274) alignment 
Range on Protein: 647-884
Range on HMM: 26-269/274.0
PQNLQKNRFCDIVALNSCRVMLRKEHADEE-SDYINAVFLHAH-RERNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ-EYPQYWPDHGAT
. . .|||...|.  .  ||.|..|....| |.|||| ...   .| .|..||| || .||.|||||.   ..  |||| .|.| ..    .|.||.  .
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

----KYGHIGVSVLSKQEKGDVISTKLEVTRKKVrrkTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQTSQQQCGN--APVLVQCSNGVGRSGTFCVIS
    .||.. . | .. |. |   .|| .   .    ...| |  . .|||.  |. | ..|||...|..|...  .  |||.| || |.|| | |  ||
eiserygdveikvekiverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiais

SVIERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKYLG
  . .|. |.|.||....  .|..| | |..  || . .... .|| 
iavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_CG7180_pd Subfamily CG7180 617-883 4.4e-56 184.7 In-house 11-290 (296) alignment 
Range on Protein: 617-883
Range on HMM: 11-290/296.0
QMTGYALEFQRLNSFTSReIPAEEKSVGEEPQNLQKNRFCDIVALNSCRVMLRKEHADEESDYINAVFLHAHRERNAFIATQHPLLETVEDFWRMVTDYD
..  . .|.. .   |.| .  ..   | . .|..|||  ..|  .  ||.|.| . .|.|||||||.  ..   ...| |. |  |||..|||.| | .
krrkfrveyklelkltpr.leigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydee

IGTIVMLNNLHELDQEYPQYWPDHGATKYGHIGVSVLSKQEKGDVISTKLEVTRK---------KVRRKTHEVRHLHHVSWPD-KCIPEVACSVLDLLDD
| ..|.| .  .  . ||.||| .. ..||.| | ......  .. . .. .|.|         .|  .|  |....   |.  . .| .. ....|.  
isavvvLtktfdfakmypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrr

VQTSQQQC----GNAPVLVQCSNGVGRSGTFCVISSVIERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKYL
|.. ...      ..||.| .|.|..||| .. |   .| .. |. .|||. .|..| .||. ||. ..| ..|.......
vrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 639-891 1.5e-55 183.0 In-house 30-301 (301) alignment 
Range on Protein: 639-891
Range on HMM: 30-301/301.0
EEKSVGEEPQNLQKNRFCDIVALNSCRVMLRKEHA--DEESDYINAVFLHAHRERNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHEL-DQEYPQ
.. .|| . .| . ||| .|. ..  |..|.....    . .|||| .... .|...|||.| |. .|. ||||.. ..   .|||. ||.|   ..  |
ksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceq

YWPDHGATKY--GHIGVSVLSKQEKGDVISTKLEVTRK--------------KVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQTSQQQCGNAPV
|||.  |...  |.. | . ..|   | .  .| |. .              | ......|  |. ..||.  .      ||  .|||   ||. | .||
ywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpv

LVQCSNGVGRSGTFCVISSVIERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKYLGSFSDYAN
.| ||..|.|||..| .|  .|  | | |.|||||.|..| ..||||  | ||.. |..|..||   | |||
vVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstyan
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 348-605 2.6e-55 182.3 In-house 24-281 (283) alignment 
Range on Protein: 348-605
Range on HMM: 24-281/283.0
SWDAARKAANKKKNRYGNIVTYDHSRVVLERVNGdedsDYINASFIH--GFDGTPRSYIASQGPPPPTFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHK
. | |    ||.|||. .||..|  || |.  .     |||||.||     .   . ||..|.|   |   ||.||....  .|||||.| |  . || .
dadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsq

YWPEK-TETYGGVTVTLHQTEVFADYVIRTFILFREERAVRRM-VRQFNFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVI
|||.. .| ||  ||||..      ..|. ..|  .  |   . .  . .  | . |      ... | . .   .    ||..||||.|.|||...| .
yWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaa

DAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENFNQT
 | ...|. .  ||. . .  .|..|. .|||..|| ..| .|||   ||.|.|   .. .|
sasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdlqst
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 629-879 6.4e-54 177.8 In-house 13-262 (283) alignment 
Range on Protein: 629-879
Range on HMM: 13-262/283.0
NSFTSREIPAEEKSVGEEPQNLQKNRFCDIVALNSCRVMLRKEHAdeesDYINAVFLH---AHRERNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNN
. .    .|  .  .    .| .|||. .||. .  || |. |      |||||||.     ... . .|..| || .|| |||.|| | .| .|||| .
evlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltk

LHE-LDQEYPQYWPDHGATKYGHIGVSVLSKQEKGDVISTKLEVTRKKVRRKTHEVRHLHHVSWpDKCIPEVACSVLDLLDDVQTSQQQCGNAPVLVQCS
| | |...  |||| .|. .||   |..     .   |  .| .  .   ..|  . |   . |  .. ..     |  .. |.. |..  ..|..| ||
lqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW.leygeqaiinslvkfnkvislqteskkgPivvhCs

NGVGRSGTFCVISSVIERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQII
.|.||...|. .|. .. ..|| |.|||.|.| .|..|..|| .| || . ....
tgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
subfamily_PTPN23_pd Subfamily PTPN23 619-882 7.7e-54 177.4 In-house 15-279 (288) alignment 
Range on Protein: 619-882
Range on HMM: 15-279/288.0
TGYALEFQRLNSFTSREipAEEKSVGEEPQNLQKNRFCDIVALNSCRVMLRkehaDEESDYINAVFLHAHR-ERNAFIATQHPLLETVEDFWRMVTDYDI
|.   .|. |..   .|  |...|.     . .|||. ||.  .. ||.||    ... ||||| |..        ||||| || .|. |||.|| .   
taldkkfkeleqkqdke..arkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqks

GTIVMLNNLHELDQE-YPQYWPDH--GATKYGHIGVSVLSKQEKGDVISTKLEVTRKKVRrKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQT---SQ
 .|||| . .||...   .||| .   ..|.|.. |.. |..| . ..  .|... .... ....|.||.  |||.  .|.   ..|..|| |..   ..
sviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldad.avksvshlqltsWpelGvPasPetllqfldevesayeav

QQCGNAPVLVQCSNGVGRSGTFCVISSVIERLKTE-QVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKY
|.  ..|..|.|| ||||.|.|... .... |...  ..|. ||..|.| .|   |.  .|. |.|... ..
qrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
0051429 (Phosphotyrosine protein) phosphatases II 385-592 5.7e-52 172.3 In-house 4-226 (272) alignment 
Range on Protein: 385-592
Range on HMM: 4-226/272.0
SDYINASFIHGFdGT---PRSYIASQGPPPPTFEGFWRMvWEQNSQSIVMLTNLVELGKTKCHKYWP-------------EKTETYGGVTVTLHQTEVFA
|.||||... |. |    |. ...|.|| | | ..|||. .|..  .||.|....|.|. ||..|||             . | .|| ..|||...|.. 
sgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

DYVIRTFILFRE-ERAVRRMVRQFNFTVWPDKGVPQYAtaVLAFRRKVRAlnprdAGPVIVHCSAGVGRTGAYIVIDAMLEQAKINRTVD--------IR
||..|...| ..      |.|... .| ||| |||| |  .|.. . ...      |||.||||||..||| ..... .|..   .  ||        ..
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyle

NYLIALRKDRPHMVQTKEQYSFIHSAVLEAlTC
...  ||. ||..||| ||| |.. |.||.  .
eaveelraqrpgavqteeqylflyeallel.lr
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 639-883 2e-50 166.3 In-house 10-264 (270) alignment 
Range on Protein: 639-883
Range on HMM: 10-264/270.0
EEKSVGEEPQNLQKNRFCDIVALNSCRVMLRKEHADEESDYINAVFLH-AHRERNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQEY-PQY
.|... |  .. . ||. ||.     ||.| ... |... |||| ... .. |....||.. ||  |...||||. .    .|||. .|.|  ..   .|
sesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerY

WPDHGA----TKYGHIGVSVLSKQEKGDVISTKLEVTRKKvrrKTHEVRHLHHVSWPDKCIPEVAC------SVLDLLDDVQTSQQQCGNA-PVLVQCSN
|| .      ...|.| | .||.. .   | |.|....|    ..... | ....|||. .|. .       ..| .| .|. |...  .| |.|| ||.
Wpaepkekvkledgkikvlalseekeegyiltrlrleekg...eerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsa

GVGRSGTFCVISSVIERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKYL
||||.||. ..  ... |.... .|| ..|...| .|.  |.   || | |. ...| 
GvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveya
0041856 (Phosphotyrosine protein) phosphatases II 357-596 5.4e-49 161.6 In-house 1-177 (182) alignment 
Range on Protein: 357-596
Range on HMM: 1-177/182.0
NKKKNRYGNIVTYDHSRvvlervngdeDSDYINASFIHGFDGTPRsYIASQGPPPPTFEGFWRMVWEQNSQSIVMLTnlvelgktkCHKYWPektetygg
|..|||| .|. |||||          |.|||||... |   . | .|| |||.. |.. |.||..|.. ..||.||         .. |||        
nldknrysdilpydhsr..........dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywp........

vtvtlhqtevfaD-YvirtfilfreeravRRMVRQFNFTVWPDKGVPQyATAVLAFRRKVRAlnprDAGPVIVHCSAGVGRTGAYIVIDAMLEQakinrT
            . .               |.. |. .. ||| |||     .|.| ..|..    . |||.|||||||||||...... |...      
............ell..............erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....g

VDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTE
|.... .  .|. ||.||.| .|| |.. |.|| | ...|.
vsleeavklvrsrRpgmvitpnqyfflqlallellllkktr
subfamily_PTPN3_pd Subfamily PTPN3 635-882 2.8e-48 159.2 In-house 27-275 (280) alignment 
Range on Protein: 635-882
Range on HMM: 27-275/280.0
EIPAEEKSVGEEPQNLQKNRFCDIVALNSCRVMLRKEhadeESDYINAVFLHAHR----ERNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELD
  |  . |.   |.||.|||. ||.. .. ||.|...    |.||||| ..          | .|||| || .|..|||.|| . .. .|||| .| |  
kkpglaisaarkpenlsknryrdilpydatrvklkes....etdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverG

-QEYPQYWPDHG-ATKYGHIGVSVLSKQEKGDVISTKLEVTRKKVRrKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQTSQqQCGNAPVLVQCSNGVG
 .   ||||...  ..||.. | . ...|.  ..  .| ...|. . . ... .| ...|||...|. . ..|.... |.. . .  . ||.| || |.|
rvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketk.eerkilqlqylaWpdhgvPddsadflefvervrklr.sgkeePvvvhCsaGig

RSGTFCVISSVIERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVF-CYQIIQKY
|.| . ..   .  . ... . . ......|  |   |.. .|| | |  |.. |
rtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvy
subfamily_PTPN13_pd Subfamily PTPN13 624-884 4e-46 152.5 In-house 16-270 (273) alignment 
Range on Protein: 624-884
Range on HMM: 16-270/273.0
EFQRLNSFTsreiPAEEKSVGEEPQNLQKNRFCDIVALNSCRVMLRKEHAdeesdYINAVFLHAH--RERNAFIATQHPLLETVEDFWRMVTDYDIGTIV
||. |. .     | .. .||.. .| .|||. ...  .  || | .| .     |||| .....   ..  .||.| || |||.|||.|| . .   |.
efkelrelk....pldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaevia

MLNNLHELDQ-EYPQYWPDHGATK---YGHIGVSVLSKQEKGDVISTKLEVTRKKVrRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQTSQQqcGNA
|. .  | ..    .|||..   |   .. . |..|  |.. .    .|.|. ..  ....|| ||. |.|||  .|  | ..| ..  |.. |.   ..
mvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdses.gesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dag

PVLVQCSNGVGRSGTFCVISSVIERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKYLG
|..| || |.|||||. .|  |.. .. .. .|| ......|  | | | .  ||.|.|..| . |.
PivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 648-882 5.5e-46 151.7 In-house 32-258 (267) alignment 
Range on Protein: 648-882
Range on HMM: 32-258/267.0
QNLQKNRFCDIVALNSCRVMLRKEHADeesdYINAVFLHAHRERNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHEldQEYPQYWPDH--GATKY
.| ..||. | .  .  ||.||..  .    |||| ...... .||||.|| ||  |. ||. ...|... .||.| .  .  .. ...|| .   | ||
knqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvft..dnirlfwPPkmgqakky

GHIGVSVLSKQEKGDVISTKLEVTRKKvrRKTHEVRHLHHVSWPDKCipEVACSVLDLLDDVQTSQQQCGNAPVLVQCSNGVGRSGTFCVISSVIERLKT
  . |    ..|. |     ||.  |.    .|.|   ..  |  .   .    .  |.  .   | . || |..|.||.|||||||| || | .||.||
qdltvehslekeendyqiitlelkfkn..esahnvtlyyykkwnint..nnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqlerakt

EQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKY
|.| |.|. ...||  |.| |... .|....... .|
egvsdifdflrkirsqriglvdtkeryiyihellaey
0051429 (Phosphotyrosine protein) phosphatases II 677-886 3e-45 150.3 In-house 4-228 (272) alignment 
Range on Protein: 677-886
Range on HMM: 4-228/272.0
SDYINAVFLHAHRE---RNAFIATQHPLLETVEDFWRMvTDYDIGTIVMLNNLHELDQEY-PQYWP------------DHGATKYGHIGVSVLSKQEKGD
|.|||| ..        .........||  |..||||.  ...| |||.| ...|....  ..|||            ..    ||.. | .||.. . |
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

VISTKLEVTRKKVRRKTHEVRHLHHVSWPDKCIP-EVACSVLDLLDDvqtsqqqcgNAPVLVQCSNGVGRSGTFCVISSVIERLKTEQVID--------V
.| ..|..|..    ...||.|||. .||| ..| |  ...|.|| |         . |||| || |..|.||....  .....  |...|        .
yilrellltlllsagearevmhlhytdwpdhgvpqeallellellld.........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

FQVIKRIRVNRPGAVESLTQYVFCYQIIQKYLGSF
.......|  |||||.. .||.|.|......| |.
eeaveelraqrpgavqteeqylflyeallellrsl
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 649-880 3.3e-45 149.3 In-house 48-276 (439) alignment 
Range on Protein: 649-880
Range on HMM: 48-276/439.0
NLQKNRFCDIVALNSCRVMLRKEHADEESDYINAVFLHAHRERNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQeypqYWPDHGATKYGHI
.  |||. |..|..  ||.|..      | |||| ... . . . .|||| |  ||..||||.| .    ||||| || |  .    |||  . . || |
dqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk....ywpsdaevcygdi

GVSVLSKQEKGDVISTKLEVTRKKV-RRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQTSQQQCGNAPVLVQCSNGVGRSGTFCVISSVIERLKTEQ
 | |  . |  . .   . |  ..   .| . | ..|...|||| .|  |  |||.|  .......    ||.|.|| ||||.||   .   .|.||.|.
avrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklen

VIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQ
 .|.  ..| .| .|   |..| |||| |. . 
kvdikgivkvlrkqrkqmvqalcqyvfiynavl
0036282 (Phosphotyrosine protein) phosphatases II 385-583 2.1e-44 146.6 In-house 2-163 (174) alignment 
Range on Protein: 385-583
Range on HMM: 2-163/174.0
SDYINASFIHGFDGTPrSYIASQGPPPptfegFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPEktetyggvtvtlhqtevfadyvirtfilfrEERAV
|||||||.....  ||  .||.||| .     ||.|..|......|||....|||..||. ||||                                   
sdyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..............................lredl

RRMVRQFNFTVWPDKGVPQYATaVLAFRRKVRALNPR-DAGPVIVHCSAGVGRTGAYIVIDAMLEQAKiNRTVDIRNYLIALRKDRPHMVQTKEQYSFIH
.|.. |. .. ||| |||  .. .| | . |.    . . |||.|||||||||||. .... || . . ...||. ... .||. ||.|||| .|| |..
erlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly
subfamily_PTPRN_pd Subfamily PTPRN 638-879 6.3e-44 144.9 In-house 45-288 (297) alignment 
Range on Protein: 638-879
Range on HMM: 45-288/297.0
AEEKSVGEEPQNLQKNRFCDIVALNSCRVMLRKEHADEESDYINAVFLHAHRERN-AFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQEY-PQ
 . |.|.....|..|||  .... .  || |..| ..|.|||||| ..  |  |. |.|||| || .|| |||.|| .  .  ||.| .|.| . .   .
pstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckr

YWPDHGATKYGHIGVSVLSKQEKGDVISTKLEVTRKKVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQTSQQQcGNAPVLVQCSNGVGRSGTFCV
||||.|.  |.   | ..|.    |    .    .    ..|  |  .|..|||.. .|  | |.|..   |. | .    .|..| ||.|.||.|....
ywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG.rscpivvhcsdGaGrtGvyil

ISSVIERL-KTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQII
|  |..|| |  . ||.   .. .| .||| |..  |. |... .
idlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltav
subfamily_PTPN1_pd Subfamily PTPN1 640-879 1.8e-43 143.3 In-house 23-267 (290) alignment 
Range on Protein: 640-879
Range on HMM: 23-267/290.0
EKSVGEEPQNLQKNRFCDIVALNSCRVMLRKEHAdeesDYINAVFLHAHRERNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQE-YPQYWP
. .. ..|.| ..||. |.   . .|..|....     ||||| ...... .  .| || || .||. ||.|| . .  ..||||.. | .|    ||||
ptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywP

DHG---ATKYG--HIGVSVLSKQEKGDVISTKLEVTRKKVrRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQTSQQQC-GNAPVLVQCSNGVGRSGT
 .    . ..   .. | ..|...|   .  .||.. .|  ..|.|. | |...|||  .||   . |..| .|. |        |... || |.|||||
qgeeekellledtklkvkliseerksyytvrllelenlkt.qetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGt

FCVISSVIERLKTE---QVIDVFQVIKRIRVNRPGAVESLTQYVFCYQII
||.. ... ... .   . .|. .|.  .|  | | .    |  | |. |
fclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylai
subfamily_PTPN14_pd Subfamily PTPN14 634-883 2.4e-43 143.3 In-house 35-296 (300) alignment 
Range on Protein: 634-883
Range on HMM: 35-296/300.0
REIpAEEKSVGEEPQNLQKNRFCDIVALNSCRVMLRKEHADeESDYINAVFLHA--HRERNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ
..    . |... |.| .|||| |..  . .|| |   . . ...||||  ...    ..  .|..| ||  ||.|||.|| . ..  |||| . .|  .
kre.dallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgk

E-YPQYWPDH----GATKYGHIGVSVLSKQEKGDVISTKLEVTRKKvRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQTSQQQ--------CGNAP
|   .|.|..       ..|.  |.   ... . || |.|..      ..  .| || .. |||. .||   . |. |..||  ...          . |
eksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlp.skeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPP

VLVQCSNGVGRSGTFCVISSVIERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKYL
||| ||.||||.|   .   .|. |.....||. .|..|.|  |   |..|.|| | |... |||
vlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 638-879 6.1e-42 138.4 In-house 34-232 (392) alignment 
Range on Protein: 638-879
Range on HMM: 34-232/392.0
AEEKSVGEEPQNLQKNRFCDIVALNSCRVMLRKEHADEESDYINAVFLHAHRERNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDqeypqyw
. ...|.... ||.|||. .|. ..| ||.|       .|||.|| ....    .|.||.| |   ...|||||| . .. ||.|...|.| |       
iypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.......

pdhgatkyghigvsvlskqekgdvistklevtrkkVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQTSQQQCGnAPVLVQCSNGVGRSGTFCVIS
                                      ... |   | . |||| .|. ..|.| .. .|..   |    |....|| ||||.|    | 
...................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqyt.hpliihcsagvgrtgvvisid

SVIERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQII
||. . |. ...|||...  || .||  |..  || | |  .
svvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygav
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 333-589 6.7e-42 138.5 In-house 17-276 (307) alignment 
Range on Protein: 333-589
Range on HMM: 17-276/307.0
RLEAEYKNVSNEQQFSWDAARKAANKKKNRYGNIVTYDHSRVVLErVNGdEDSDYINASFIhGFDGTPRSYIASQGPPPPTFEGFWRMVWEQNSQSIVML
.|  |...... .  .  .    || .|||| ..   |..|.|.. ..|   |||| | .. |    |. .|..|||   |   || |. ... .|..||
alvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvk.fdg.lasdyihanyl.giaikpkkficaqgplentqysfwamaiqekvesviml

TNLVELGKTKCHKYWPE---KTETYGGVTVTLHQTEV------FADYVIRTFILFREERAVRRMVRQFNFTVWPDKGVPQYATAVLAFrrkVRALNpRDA
 ...||.| ||..|||    .. ..|  . |.  ...        . .|    |  .     | ....... |||.||||   . . .   . | .  | 
ckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainl...leavr.ydt

GPVIVHCSAGVGRTGAYIVIDAMLEQAK-INRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
 ||.|||||||||.|. . |  . ..        |... .  ||..|.. .||. || ..|  .|| 
npvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley
0049772 (Phosphotyrosine protein) phosphatases II 331-592 8.5e-42 139.3 In-house 20-282 (314) alignment 
Range on Protein: 331-592
Range on HMM: 20-282/314.0
GIRLEAEYKNVSNEQQFSWDAARKAANKKKNRYGNIVTYDhSRVVLERVNGDeDSDYINASFIHGFdgtpRSYIASQGPPPPTFEGF----------WRM
...|.  . . |  . ... .|.. .|..|||| .|. .| .||.| ..... .|||||||...||    ...||.||| . |.. |          |||
klllvlnrrslsvlpeltilvadlflnrdknryldilpad.nrvilpglpvs.gsdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrm

V--WEQNSQSIVM---------------------LTNLVELGktkchkywP--------EKTetyggvtvtlhqtevfadyvirtfilfREE---RAVRR
|  ...|.  |||                     |..| ..|        .        .                             .|      . |
vlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng........neptaadlellk...........................eelydpelfer

MVRQFNFTVWPDKGVPqYATAVLAFRRKVRALnpRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKinrtVDIRNYLIALRKDRP-----HMVQTKEQYSF
.. ..  . .|| ..|     ...| . ....  .. |||.|||.||.|||| ..|.. .. . .    |...  |  .|. ||     ..... ||| |
lgikylripvpDgsap.lledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyef

IHSAVLEALTC
|. |.||.|  
ilealleylkf
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 354-588 8.8e-42 137.7 In-house 53-281 (290) alignment 
Range on Protein: 354-588
Range on HMM: 53-281/290.0
KAANKKKNRYGNIVTYDHSRVVLErvNGdEDSDYINASFIHGFDgtpRSYIASQGPPPPTFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPEKT--
| .. ||||| ..|  | .||.|.  .|  | ||. | ...| .     .| .||.   |   .|||| ...   |||| .|.| ||.||..|.|||   
kntefkknrykdvvcndktrvilk..dG.ydGdyvhanyvkGlk...amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGe

-ETYGGVTVTLHQTEVF-ADYVIRTFILFREERAVRRMVRQFNFTVWPDKGVPQYATAVLAFRRKVRALnprdAGPVIVHCSAGVGRTGAYIVIDAMLEQ
  |.| .||.  . .   |. . .|. .   .     ... ..   |||| |.. . |.|   | .| .    .|||.||||||.||||... |.. |. 
vltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka....sGpvvvhcsaGiGrtGtfvaievglqi

AKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
    . .|. .   |||. |   ||   ||  .  ..|.
lldGkeldlldlvralrnsrlnsvqvdiqylalveilld
0046846 (Phosphotyrosine protein) phosphatases II 379-588 4.2e-41 135.9 In-house 6-171 (176) alignment 
Range on Protein: 379-588
Range on HMM: 6-171/176.0
VNGDEDSDYINASFIHGFDgtprsYIASQGPPPPTFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPEKTETYGgvtvtlhqtevfadyvirtfilf
   |.|.|||||..| |       .|| ||| | |.. |..|..|.. . .|.||..||||. ||. |||| ..                          
lgldldldyinanlilgsr.....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.......................

reeravrrmvrQFNFTVWPDKGVPQYaTAVLAFRRKVRALNPRDaGPVIVHCSAGVGRTGAYIVIDAMLEqakiNRTVDIRNYLIALRKDRP-HMVQTKE
           |. .. ||| |||.. ...| . . .|    .. |||.||||||.||||...... .      .. ... . |  .|. || ..||| |
...........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpe

QYSFIHSAVLE
|| |.. ..|.
Qyrflyefell
0036282 (Phosphotyrosine protein) phosphatases II 677-877 4.3e-41 135.8 In-house 2-164 (174) alignment 
Range on Protein: 677-877
Range on HMM: 2-164/174.0
SDYINAVFLHAHRERNAFIATQHPLLetvedFWRMVTDYDIGTIVMLNNLHELD-QEYPQYWPDhgatkyghigvsvlskqekgdvistklevtrkKVRR
|||||| .|. ..  . .||.|.||      ||.|. ...| |.|||....||.    ..|||.                                .   
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lred

KTHEVRHLHHVSWPDKCIPEVACsVLDLLDDVQTSQQQCGNAPVLVQCSNGVGRSGTFCVISSVIERLKtEQVIDVFQVIKRIRVNRPGAVESLTQYVFC
 .... ..... ||| . |...  .|.... |.. ...... |||| || ||||.||....  .. .|. | ..|........|  |||.|..  || |.
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfl

YQ
|.
yy
0041856 (Phosphotyrosine protein) phosphatases II 649-882 4.8e-41 135.7 In-house 1-170 (182) alignment 
Range on Protein: 649-882
Range on HMM: 1-170/182.0
NLQKNRFCDIVALNSCRvmlrkehadeESDYINAVFLHAHRERNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNnlheldqeYPQYWPDHGatkyghi
|| |||. ||.  .  |           .||||| ..   .  . |||||.|||.||.||.||. ...|.|||.|.         ..|||..        
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt........eelywpell.......

gvsvlskqekgdvistklevtrkkvrrkTHEVRHLHHVSWPDKCIPEvACSVLDLLDDVQTsqqqcGNAPVLVQCSNGVGRSGTFCVISSVIERlkteQv
                            .... ......||| ..|.   ..||....|.       . |||| || ||||.||....  ....    . 
............................erlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.

IDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKY
.......| .|  |||.|... ||.|.....  .
vsleeavklvrsrRpgmvitpnqyfflqlallel
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 648-879 5.2e-41 135.4 In-house 2-235 (237) alignment 
Range on Protein: 648-879
Range on HMM: 2-235/237.0
QNLQKNRFCDIVALNSCRVMLRKEHADeeSDYINAVFLHAHR-ERNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQE-YPQYWPDHG-ATK
.|  |||. .||| . .||.|.   ..  |||||| .|.      . .||.| ||  . .|||.|| .     ||||  | | ...   .|||.    . 
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGHIGVSVLSKQEKGDVISTKLEVTRKKVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQ-TSQQQCGNAPVLVQCSNGVGRSGTFCVISSVIERL
|| . ||.  |.|  |     | ....   ..   .   .  ||||. .|. ....| .  ..   |.     .| .. || ||||.| | || ... . 
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

KTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQII
| ..|.|... .. |  .||  ...  |||| .| |
kekkvvdiynyvysieedrpyiiqtkdqyvfihqti
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 597-882 6.1e-41 134.9 In-house 9-282 (290) alignment 
Range on Protein: 597-882
Range on HMM: 9-282/290.0
IQSENFNQTTqklaSVNRKFQMTGYALEF-QRLNSFTSREipAEEKSVGEEPQNLQKNRFCDIVALNSCRVMLRKEhadEESDYINAVFLHAHreRNAFI
.|.| |.. .    |   | .. ..| |. ..|  .   .    |... ..  ...|||. |.|  .  ||.|.      . ||. | ...    .  ||
vqteafekfa....sdvvkknvdelakeyleklkpylpvq..ylerkifdkntefkknrykdvvcndktrvilkdG...ydGdyvhanyvkGl..kamfi

ATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ-EYPQYWPDHG--ATKYGHIGVSVLSKQEKGDVISTKLEVTRKKVRRKTHEVRHLHHVSWPDKC
 || .| .|| |.|||| . .. .|||| .| |  .    ||.|..   .  .|.| |    ...| . |  |.   |.|   | | ..||. .|||||.
ltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdks

IPEVACSVLDLLDDVQTSqqqcgNAPVLVQCSNGVGRSGTFCVISSVIERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKY
..  . ..| .|  ...      . || | || |.||.|||  |   .. |   . .|. .... .|  | ..|.  .||.   .|. ..
valstlallrtlrilrka.....sGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 649-876 1.4e-40 133.9 In-house 8-234 (239) alignment 
Range on Protein: 649-876
Range on HMM: 8-234/239.0
NLQKNRFCDIVALNSCRVMLRKEHADEESDYINAVFLHAHR-ERNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELD-QEYPQYWPDHgATKYG
|  |||...||. .  ||.| |   |  |||||| .|. .    .|.||||  .  .  |||||. .     ||||  | |   ..  |||||  ..|| 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.tskyc

HIGVSVLSKQEKGDVISTKLeVTRKKVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVqTSQQQCGNAPVLVQCSNGVGRSGTFCVISSVIERLKTE
 . |..   .   | |   . |  .  . . . | . |   |||| .|. | .|| |   . | .   |  | ...|| ||||.|.| || ... . | .
nlrvtlrktevfadyiirtf.vmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrki.tkdslpgarpwvihcsagvgrtgaflvidamlrqakkq

QVIDVFQVIKRIRVNRPGAVESLTQYVFCY
. .|.|. .| || .||  |..  |||| .
ktvdifnyvkairedrphmvqtseqyvfih
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 649-876 1.4e-40 134.0 In-house 7-233 (239) alignment 
Range on Protein: 649-876
Range on HMM: 7-233/239.0
NLQKNRFCDIVALNSCRVMLRKEHADEESDYINAVFLHAHR-ERNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELD-QEYPQYWPDHgATKYG
|  |||...||. .  ||.| |   |  |||||| .|. .    .|.||||  .  .  |||||. .     ||||  | |   ..  |||||  ..|| 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.tskyc

HIGVSVLSKQEKGDVISTKLeVTRKKVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVqTSQQQCGNAPVLVQCSNGVGRSGTFCVISSVIERLKTE
 . |..   .   | |   . |  .  . . . | . |   |||| .|. | .|| |   . | .   |  | ...|| ||||.|.| || ... . | .
nlrvtlrktevfadyiirtf.vmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrki.tkdslpgarpwvihcsagvgrtgaflvidamlrqakkq

QVIDVFQVIKRIRVNRPGAVESLTQYVFCY
. .|.|. .| || .||  |..  |||| .
ktvdifnyvkairedrphmvqtseqyvfih
0049772 (Phosphotyrosine protein) phosphatases II 608-884 4.7e-40 133.6 In-house 5-281 (314) alignment 
Range on Protein: 608-884
Range on HMM: 5-281/314.0
KLASVNRKFQMTGYALEFQRLNSFTSREIPAEEKSVGEEPQNLQKNRFCDIVALNsCRVMLRKEHADEeSDYINAVFLHAHrerNAFIATQHPLLETVED
 |||...  ..  .  ....||. . . .|.    |.  . |  |||. ||.  . .||.| ... .  |||||| ... .   ..|||||.|| .||.|
plasfsellihddllklllvlnrrslsvlpeltilvadlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvd

F----------WRMV--TDYDIGTIVM---------------------LNNLHEL-DQEYPQYWPDHGatkyghigvsvlskqekgdvistklE------
|          ||||   |... .|||                     |..| .. ..  .......                          |      
freepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgngneptaadlellk.........................eelydpe

-VtrkkvrrkTHEVRHLHHVSWPDKCIPeVACSVLDLLDDVQTSqqqCGNAPVLVQCSNGVGRSGTFCVISSVIERLKteqViDVFQVIKRIRVNRP---
 .        .... ..... .|| . |     ....|. ...      . |||| |. |.||.|||.|.  .. .|.   | .. ......|  ||   
lf........erlgikylripvpDgsap.lledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllg...v.sleealedvrlkRpinp

--GAVESLTQYVFCYQIIQKYLG
  |..|.| ||.|.......|| 
npgfieqleqyefilealleylk
0043147 (Phosphotyrosine protein) phosphatases II 381-583 1.7e-39 130.6 In-house 1-154 (172) alignment 
Range on Protein: 381-583
Range on HMM: 1-154/172.0
GDEDSDYINASFIHGFDGTPRsYIASQGPPPPTFEGFWRMVWEQNSQSIVMLTNLvelgktkchkywpektetyggvtvtlhqtevfadyvirtfilFRE
|||.|||||||....   ..| .|| ||| . |.. ||||..|.. . ||.||.|                                          .  
gdegsdyinasyldlyyipdr.fiatqgplrntladfwrmlkelgithivnltel..........................................lyd

ERAVRRMVRQFNFTVWPDKGVPqYATAVLAFRRKVRA-LNPRDAGPVIVHCSAGVGRTGAYIVIDAMLeqakinRTVDIRNYLIALRKDRPHMVQTKEQY
   . |.. |. .. ||| |||  .  .| | . ..  |. .. |||.|||||||||||. .... ||      . ... . .  .|. ||..||...||
pellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqy

SFIH
 |..
rfly
0049260 (Phosphotyrosine protein) phosphatases II 399-583 1.5e-38 127.2 In-house 7-143 (152) alignment 
Range on Protein: 399-583
Range on HMM: 7-143/152.0
TPRSYIASQGPPPPTFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWpektetyggvtvtlhqtevfadyvirtfilfreeravrrmvrQFNFTVWPD
 |. .|| ||| | |.. ||||..|.. . |||||.|.|||| ||..|.                                          |. .. |||
mpfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................................qylhlpwpD

KGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLeqakinRTVDIRNYLIALRKDRPHMVQTKEQYSFIH
 |||. .  .| . . .. |. .. |||.|||||||||||...... ||      . |.. ...  .|. ||..|....|. |..
hgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
0043147 (Phosphotyrosine protein) phosphatases II 674-877 1.9e-38 127.2 In-house 2-155 (172) alignment 
Range on Protein: 674-877
Range on HMM: 2-155/172.0
DEESDYINAVFLHAHRERNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLheldqeypqywpdhgatkyghigvsvlskqekgdvistklevtRKKV
|| |||||| .|. ..  . ||||| || .|..|||||. ...|..||.|..|                                            .  
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydp

RRKTHEVRHLHHVSWPDKCIPeVACSVLDLLDDVQTSQQQCGNAPVLVQCSNGVGRSGTFCVISSVIerlkteQVIDVFQVIKRIRVNRPGAVESLTQYV
   .... ......||| . |  .  .|..|. ... .... . |||| || ||||.||....  ..      . ........ .|  |||||..  || 
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyr

FCYQ
|.|.
flyy
0046846 (Phosphotyrosine protein) phosphatases II 669-884 2.4e-38 127.0 In-house 4-174 (176) alignment 
Range on Protein: 669-884
Range on HMM: 4-174/176.0
RKEHADEESDYINAVFLHAHRernaFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQEY-PQYWPDhgATKYGHigvsvlskqekgdvistkle
|. . |. .||||| ..  .|    .||||.|| .|..||..|. ...|...|.|....||..   |.|||.   .|.|.                    
rllgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi....................

vtrkkvrrkthevrHLHHVSWPDKCIPEVaCSVLDLLDDVQTSQQQcgNAPVLVQCSNGVGRSGTFCVISsvieRLKTEQVIDVFQVIKRIRVNRP-GAV
              . .|. ||| ..|.    .|.||. ... ...  . |||| || |.||.||....      |..|. ..|.......|  || |||
..............qylhlpwpDhgvpdl.elllellefirealke..ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgav

ESLTQYVFCYQIIQKYLG
..  || |.|. ....|.
qtpeQyrflyefellllk
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 634-883 1.8e-37 123.7 In-house 24-277 (287) alignment 
Range on Protein: 634-883
Range on HMM: 24-277/287.0
REIPAEEKSvGEEPQNLQKNRFCDIVALNSCRVMLRKEhADEESDYINAVFLHAHRERNAFIATQHPLLETVEDFWRMVTDYDIGTIVML-NNLHELDQE
.  .|  |.  ||  . .|||..|.. ..  ||.| .| ..  |||||| .. .... .||||.| |.  || ||||.| .    .....  .. |  ..
esstatfka.aeelaavkknryadvlPiddtrvllsae.gelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlk

YPQYWPDH-GATKYGHIGVSVLSKQEKGDVIST-KLEVTRKKvRRKTHEVRHLHHVSWPDKCIPEVAC----SVLDLLDDVQTSQQQCGNAPVLVQCSNG
  .|||..    . |   | .|... |    ..  | .   .  |... |. |. .||||| ..  |      |||  . .. ...  .  |..| .. |
cykywPerevPmrvGGysvvlldydikePeygvralrlidle.trearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvG

VGRSGTFCVISSVIERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKYL
.||||..  .  ...||.    .|| .|. |.|  | . | .  |. . |. .  | 
iGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyy
0044763 (Phosphotyrosine protein) phosphatases II 369-587 4.7e-37 122.7 In-house 2-168 (178) alignment 
Range on Protein: 369-587
Range on HMM: 2-168/178.0
YDHSRVVLERVNGDEDSDYINASFIHGFdgtprSYIASQGPppptfEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPEKTEtyggvtvtlhqtevfa
.|..||.|. . | | |||||||.| ..      |..|..|     . ......|.. ..||.||. .|||. ||..||||...                
ldrtrvllsnleglersdyinaseilpg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

dyvirtfilfreeravrrmvRQFNFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQakinrTVDIRNYLIALRKD
                     |. .. .|| |||.    .|.| . .... ... |||.|||||||||.|. .... |...      ... . .  .|. 
....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrer

RPhMVQTKEQYSFIHSAVL
|| .|.. .|. ...   |
Rp.ivpnpgqlrqLyefel
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 331-588 5.5e-37 122.1 In-house 21-285 (305) alignment 
Range on Protein: 331-588
Range on HMM: 21-285/305.0
GIRLEAEYKNVSNEQQFS-WDAARKAANKKKNRYGNIVTYDHSRVVLervNGDEDSDYINASFIHGfDGTPRSYIASQGPPPPTFEGFWRMVWEQNSQSI
 . | ||....   ..|    | ..| ...|||| ..   |. || |   .|    .|| | ..      |. .| .| |   |   || | .... ..|
paglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvkl...egpwpheyihanyvst.ptnpkrfictqaplektcadfwymclqdkveai

VMLTNLVELGKTKCHKYWPEKTE-------TYGGVTVTLHQTEV--F----ADYVIRTFILFREERAVRRMVRQFNFTVWPDKGVPQYATAVLAFRRKVR
 || ||.| |  ||..|.. | .           ..| .  ..   |    .  | .| ..     .  | | .. .  |||.|||   .|.| .  | |
fmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekar

ALNprdaGPVIVHCSAGVGRTGAYIVIDAMLEQAKINRTVDIR-NYLIALRKDRPHMVQTKEQYSFIHSAVLE
..     ||..||||||.||||. .... .|.|    . ..     |  .|..|   .|| .|| |.|  .|.
psk....gpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 355-588 6e-37 122.1 In-house 31-257 (267) alignment 
Range on Protein: 355-588
Range on HMM: 31-257/267.0
AANKKKNRYGNIVTYDHSRVVLERVNGDedsdYINASFIHGFDgTPRSYIASQGPPPPTFEGFWRMVWEQNSQSIVMLTNlveLGKTKCHKYWPEK---T
  |...||. . . ||..||.|   . .    |||||...|.  | . .|. |.|   |   |. .. .|.   ||.||.    .. . ...|| |   .
eknqernrlddnlpyddtrvilrtkeee....yinasyvegyk.tknafivtqdplkntitdfltvihdqkvpvivlltk...vftdnirlfwPPkmgqa

ETYGGVTVTLHQTEVFADYVIRTFIL-FREERAVRrmVRQFNFTVWPDK-GVPQYATAVLAFRRKVRALNprDAGPVIVHCSAGVGRTGAYIVIDAMLEQ
. |  .||     .   || | |. | |..| |    |  . .  |  .     |   ...   | .  |     |..|.||.||||.|...|||..||.
kkyqdltvehslekeendyqiitlelkfknesahn..vtlyyykkwnintnnkpylkplfgilaknqlen..gnrPlvvacsdGvGrsGtflvidsqler

AKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
|| . ..|| ..|  .|. |. .|.|||.| .||  . |
aktegvsdifdflrkirsqriglvdtkeryiyihellae
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 647-883 2.9e-36 120.0 In-house 41-271 (288) alignment 
Range on Protein: 647-883
Range on HMM: 41-271/288.0
PQNLQKNRFCDIVALNSCRVMLRkehaDEESDYINAVFLHAHRERNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQEY-PQYWPDHG--AT
 .|  ..|. ..   . .|| |     |.   ||.|  . ... .. .| .| ||  |.| .|.|. . |.  ||||..| |. .|   .|.| .   ..
ianptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGeka

KYGHIgvSVLSKQEKgDVISTKLEVTRKKVRRKTHE---VRHLHHVSWPDKCIPEVACSVLDLLDDVqtsqqQCGNAPVLVQCSNGVGRSGTFCVISSVI
..|..      |... . |   ..|.  .. ....|   |..||   |.|...||   | | ||. .     .  . |..|..|.||||.||. .|  ..
rigrl..ctvvkkkr.adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililial

ERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKYL
| |. .  . . ..... | .|  |...  ||.. .... ..|
eslrlddflgirsllaklreerfkaiqtemqylyvhrcvleel
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 349-588 4.9e-36 118.9 In-house 46-287 (305) alignment 
Range on Protein: 349-588
Range on HMM: 46-287/305.0
WDAAR-KAANKKKNRYGNIVTYDHSRVVLERVNgdeDSDYINASFIHGFDGTPRSYIASQGPPPPTFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYW
..| .    .. |||| ..   |.| | |.. .    |||| | ..       . .|..|||   | . || || ... . |||| . ||||| || .||
fnanqsadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqyw

P----EKTETYGGVTVTLHQ-T-EVFADYVIRTFILFREE-RAVRRMVRQFNFTVWPDKGVPQYATAVLAFRRKVRAlnprDAGPVIVHCSAGVGRTGAY
|    || |  .|. |     .  .  |  |.  .|        .  ||....| |||.|||    . | .   .|        |..||||||.||||. 
paaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairg....skvpivvhcsagigrtgti

IVIDAMLEQAKINRTV-DIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
. |. .||.   |. .  . . . ||| .| . .|.  || |||  .|.
vaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 635-881 6.3e-36 118.7 In-house 19-293 (297) alignment 
Range on Protein: 635-881
Range on HMM: 19-293/297.0
EIPAEEKSVGEEPQNLQKNRFCDIVALNSCRVMLRKEHadEESDYINAVFLHAHRERN--AFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQE
|  .|. |.   .  |.|||. ||.| .. || |..     |.||||| ..    | .   .| .| || .||.|||..|.. |...|||. .| |  ..
eargesfssakrnsslrknryrdilatddtrvkllrvi..terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrd

--YPqYWPD--HGATKYGHIGVSVLSKQ--EKGDVISTKLEVTRKkvrRKTHEVRHLHHVSWPDKCIP----EVA------CS-------VLDLLD----
  .| |||.   .  | |.. |  ||.   |   || |.|..  .    ..  |||  ..||||. .|    ..       ||       .| |..    
kcap.ywpsvvqerlkagdvvveflsstsdefdrviltelqliyr...sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemfta

----DVQTSQQ-QCGNAPVLVQCSNGVGRSGTFCVISSVIERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQK
     ... .  .  ||..|| || ||||||       ....|. ... ||  ... .| .|.  |..| |. ..|... |
mvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_CG42327_pd Subfamily CG42327 337-516 7.4e-36 118.4 In-house 10-191 (319) alignment 
Range on Protein: 337-516
Range on HMM: 10-191/319.0
EYKNVSneQQFSWDAARKAANKKKNRYGNIVTYDHSRVVLERVNGDEDSDYINASFIHGFDGTPRSYIASQGPPPPTFEGFWRMVWEQNSQSIVMLTNLV
|....   |  .   .  .. |.|.|. |.|   ..||||.|.  |. . |..||.. |.| .| ||||.| .   .   |||.||||.|. || ||.| 
efrdlP..qliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdls

ELGKTKCHKYWPEK-----TETYGGVTVTLHQTEVFADYVIRTFILFREERAVRRMVRQFNFtVWPDKGVPQYATAVLAFRRKVR
|||  .| .|.| |     |..|| . ||| . ||   |.| |..| | ..   | .  . .  |.. .||   .|..|   .||
elGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevr
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 353-588 7.4e-36 118.2 In-house 33-267 (281) alignment 
Range on Protein: 353-588
Range on HMM: 33-267/281.0
RKAANKKKNRYGNIVTYDHSRVVLER-VNGDEDSDYINASFIHGfDGTPRSYIASQGPPPPTFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPEKT
 .  |.||||| ||   | ||| |.  .   . .||| | .|.      | || .|||   |   ||||.|..|. .|||| ...|  . || .|.| ..
nqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirs.pflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprna

E---TYGGVTVTLHQTEVFADYVIRTFILFREERavRRMVRQFNFTVWPDKGVPQYATAVLAFRRKVRAlnpRDAgPVIVHCSAGVGRTGAYIVIDAMLE
     .  ..|.  .. |    |   . |  |     |.. .. .  |||  ||. .  .|   ||.||   | . | ..||||||||.|. . ..  |.
hcclqfdklsvsyedstvnkslvttrlnlsyege..trlithwlwkewpdwqvpessevmlkilrkira...rst.ppvihcsagvgrsgtlmaveialq

QAKINRTV-DIRNYLIALRK-DRPHMVQTKEQYSFIHSAVLE
  .   |. ||.. .  ||   |   ||| .|| .|   .|.
sihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_ptpA1_pd Subfamily ptpA1 353-548 9.9e-35 115.1 In-house 43-254 (418) alignment 
Range on Protein: 353-548
Range on HMM: 43-254/418.0
RKAANKKKNRYGNIVTYDHSRVVLERVNGDEDSDYINASFIHGfdGTPRSYIASQGPPPPTFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPEKTE
 |  |  |||| ||.  .|.|| |....  | |||||| .| |    |. .|..||| | |   |||||||.  . ||||.   |  . || .||||.  
dkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg..aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqig

TyGGVTVTLHQTEVFADYVIRTFILFR-EERA------------VRRMVRQFNFTVWPDKGVPQYATAVLAF-----RRKVRALNPRD-AGPVIVHCSAG
    ...     |||  | .    . .  ||               | . |...  |||. .|...  .  .      |. . .   |   |.|||||||
g.eqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsag

VGRTGAYIVIDAMLE
|||||..     |..
vgrtgtfctavimmk
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 647-883 1.4e-34 114.5 In-house 39-277 (307) alignment 
Range on Protein: 647-883
Range on HMM: 39-277/307.0
PQNLQKNRFCDIVALNSCRVMLRKEHAdeESDYINAVFLHAHRERNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ-EYPQYWPDHGATK-
  | .|||. |. . . .|.... . .   |||| | .|    . . ||..| || .|. .|| |. . .. ...|| .. || .    ||||     | 
santdknryqdvkcqdkgrivvkfdgl..asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqkl

-YGHIG----VSVLSKQEKgDVISTKLEVTRKKV--RRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQTSQqqcgnAPVLVQCSNGVGRSGTFCVIS
 .|. .    |. |  ..        ..||  ||   .|.  ..||    |||. .|..  . ..||. |.  .      ||.| || |||||||   ||
vfgeapntisvanlgakkl.apdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydt.....npvvvhcsaGvGrsGtivais

SVIERL-KTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKYL
 | ... . .   |. .... .| .|. |...  ||.. .... .|.
lvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 334-595 1.7e-34 114.1 In-house 21-276 (288) alignment 
Range on Protein: 334-595
Range on HMM: 21-276/288.0
LEAEYKNVSNEQQFSwDAARKAANKKKNRYGNIVTYDHSRVVLErvngdEDSDYINASFIHGFDGTPRSYIASQGPPPPTFEGFWRMVWEQNSQSIVMLT
|. ||..  || .    .    ||  ..|| |.   | .|| |.     .|.|.  |. .      .|  | .| |   | | .|.|. |.. . ||||.
lkkeyrdspneasid.iidsfianptrdryenlprcditrvkls.....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlc

NLVELGKTKCHKYWPEKTET---YGG-VTVTLHQTeVFADYVIRTF-ILFREERAVRRMVRQFNFTVWPDKGVPQYATAVLAFRRKVRALNprdaGPVIV
.|.|.|| |  .|.| |      .|   ||. ..  .  | ...   .   .|   . .|..  .  |.|.|||.   . | .   ...|.     |..|
ellekGkeksaeyfPsklGekarigrlctvvkkkr.adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslq....kPivv

HCSAGVGRTGAYIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNT
|.||||||||. |.|  .||.....  . ||. |  ||..| . .||. || ..|  ||| |     
hssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelllkky
0049260 (Phosphotyrosine protein) phosphatases II 688-877 7.8e-34 111.9 In-house 5-144 (152) alignment 
Range on Protein: 688-877
Range on HMM: 5-144/152.0
HRERNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQE-YPQYWpdhgatkyghigvsvlskqekgdvistklevtrkkvrrkthevrHLHHV
..  ..|||||.|. .|..|||||. ...|.|||||..|.||. .  .||.                                            . .|.
yampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................qylhl

SWPDKCIPEVACSVLDLLDDVQTSqQQCGNAPVLVQCSNGVGRSGTFCVISSVIerlkteQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQ
 ||| . |. .  .|.||. ..   ..  . |||| || ||||.||....  ..      . ..........|  |||||..  |. |.|.
pwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
0051082 (Phosphotyrosine protein) phosphatases II 384-587 2e-33 110.4 In-house 2-150 (151) alignment 
Range on Protein: 384-587
Range on HMM: 2-150/151.0
DSDYINASFIHGFdgtprsYIASQGPppptFEGFWRMVWEQNSQSIVMLTNLVELGktKCHKYWPEKTetyggvtvtlhqtevfadyvirtfilfreera
 |||||.|.. |.      ...|.||     . |.....|.. ..||.|....| |  .|..|.||                                  
lsdyinfsyvtgg......lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg................................

vrRMVRQFNFTVWPDKGVPQYATAVLAFRRKVRAlnpRDAGPVIVHCSAGVGRTGAYIVIDAMLEQakinrtVDIRNYLIALRKDRPHMVQTKEQYSFIH
  . |... .. ||| |.|..  |||.| .....    . |||.||||||.||||. .... ||..      |..   |  .|. ||..||...|. |..
..ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfql

SAVL
 |.|
fall
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 331-596 2.7e-33 110.0 In-house 18-282 (312) alignment 
Range on Protein: 331-596
Range on HMM: 18-282/312.0
GIRLEAEYKNVSNEQQFSWDAArKAANKKKNRYGNIVTYDHSRVVLervNGDEDsDYINASFIHgFDGTPRSYIASQGPPPPTFEGFWRMVWEQNSQSIV
  .|  ||| | |  . |  .|     |  ||| ||  .|  |  |    |||.  || | |..     |  ....|||   |   ||...    | ||.
pqqltkeykavgnivsdsecta.flkfkdlnrypniqcwdrgrftl...agden.fyihanfvk.ictkperfvctqgplentcthfwqlalslgstsii

MLTNLVELGKTKCHKYWPEKTetyGGvtVTLHQTEVFADYVIR--------TFILFREERAVRR------MVRQFNFTVWPDKGVPQYATAVLafrRKVR
.|. .|| |  || ||  .     |   | | .  |...|.            |  |  . | .       . ..... |||.|.|.   . |   | . 
llcgfvedgsekcakyisdiv...gf..vdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtal...rlls

ALNpRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTE
|.. .|  ||| ||||||||||. ..|..|.   .  |  .... .. |||||   |..  || .   .||| | .    
avk.kdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskgly
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 689-880 2.8e-33 109.9 In-house 233-435 (440) alignment 
Range on Protein: 689-880
Range on HMM: 233-435/440.0
RERNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHelDQEYPQYWPDHG-ATKYGHIGVSvlsKQEKGDVISTKLEVTRKKVRRKTHEVRHLHHVS
  .||||||| ||  || ||||.| || | ||.|||.|   |.    |||    .  .| . |    ..   ..   |.     | . . ||.| .   .
skknafiatqmpldstvldfwrlvhdyristiimlnqln..dktcsiywpvntrsvtfgpftvg...hkgsenmnrvkvrtlelkykeevheirqfevqt

WPDKCIP-----EVAC--SVLDLLD-----DVQTSQQQ--CGN-APVLVQCSNGVGRSGTFCVISSVIERLKTEQVIDVFQVIKRIRVNRPGAVESLTQY
||          .  |  .||.|.|     ..| | .|   |.  |.||.|  |.  || || .  ..|.|. .  ||||| .. .|. ||  | .||.|
wptwiqsdgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvptltdy

VFCYQIIQ
..||... 
llcykllt
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 688-878 4.8e-33 109.0 In-house 1-199 (199) alignment 
Range on Protein: 688-878
Range on HMM: 1-199/199.0
HRERNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ-EYPQYWP--DHGATKYGHIGVSVLSKQEKGDVISTKLEVTRKK-VRRKTHEVRHL
|. .  .||||||| ||. |||.|| .   | |||.|.     . .|| |||  . |..||| . |.. .   | |   | | .| .      | |. | 
hkgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishy

HHVSWPDKCIPEVACSVLDLLD--DVQTSQQQCGNAPVLVQCSNGVGRSGTFCVISSVI---ERLKTeQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQI
   || .|  |.||  |  ..   .|    .|  .|||.|.||.| | .| |  .   .   |  ||  |.|.|.| ||.|  | | . || .| | ||.
qftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 337-598 7.3e-33 108.4 In-house 32-297 (310) alignment 
Range on Protein: 337-598
Range on HMM: 32-297/310.0
EYKNVSNEQQFSWDAARKAANKKKNRYGNIVTYDHSRVVLErVNGDEDSDYINASFIHGfDGTPRSYIASQGPPPPTFEGFWRMVWEQNSQSIVMLTNLV
.|...  .|. |        . .|||| ..|  | ||| |. ..     ||| | ...  .    ..| ||||   |   ||||.... ..||..| . .
qyrkldakqdssltyeaykkymhknrysdvvcldtsrvklk.idksryedyihanyvkt.nylrstficsqgplqhtiidfwrmifqeraesilllckvg

ELGKTKCHKYWPE--KTETYGGVTVTLHQtEVFADY----VIRTFI----LFREERAVRRM--VRQFNFTVWPDKGVPQYATAVLAFrrkvRALNPRDAG
| |. ||  |||    ||||| . ||    |   ..    .  ||.       |. |  .   |   ..  |||.|||.     .      | |     |
eegrpkcvgywpslgvtetygcirvtnls.esseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpq....rllaqvrhg

PVIVHCSAGVGRTGAYIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLeALTCGNTEIQ
|..||||||..|... . ..  .....    ||. .    |.|.|   .||. || .|.   . ... |.||. 
pcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvri.ifargeteva
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 692-878 9.7e-33 108.0 In-house 4-198 (198) alignment 
Range on Protein: 692-878
Range on HMM: 4-198/198.0
NAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ-EYPQYWP--DHGATKYGHIGVSVLSKQEKGDVISTKLEVTRKK-VRRKTHEVRHLHHVS
  .||||||| ||. |||.|| .   | |||.|.     . .|| |||  . |..||| . |.. .   | |   | | .| .      | |. |    |
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDKCIPEVACSVLDLLD--DVQTSQQQCGNAPVLVQCSNGVGRSGTFCVISSVI---ERLKTeQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQI
| .|  |.||  |  ..   .|    .|  .|||.|.||.| | .| |  .   .   |  ||  |.|.|.| ||.|  | | . || .| | ||.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 334-513 4.7e-32 106.0 In-house 9-191 (297) alignment 
Range on Protein: 334-513
Range on HMM: 9-191/297.0
LEAEYKNVSNEQQ-FSWDAARKAANKKKNRYGNIVTYDHSRVVLERVNgdEDSDYINASFIHGFD-GTPRSYIASQGPPPPTFEGFWRMVWEQNSQSIVM
||||.  . .|..  |. .|.. .  .|||| .|...| .|| | ||    ..||||| ..   |  ..  || .|||   | . ||..|.||. . |||
leaekdllldeargesfssakrnsslrknryrdilatddtrvkllrvi..terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivm

LTNLVELGKTKCHKYWPEKTE---TYGGVTVTlHQTEVFAD--YVIRTFiLFREERAVRRMVRQFNFTVWPDKGVPQYATAVLAFRR
...| | |. ||  |||.  .   . | | |  . ...  .   || |  |    |. .|.||  .|  |||.|||     .  |. 
vaklqedGrdkcapywpsvvqerlkagdvvve.flsstsdefdrvilte.lqliyrsesrvvrhvqflswpdhGvpsdledlvrfqa
PTPc_DSPc_SM00012 780-880 8.3e-32 104.9 In-house 2-104 (105) alignment 
Range on Protein: 780-880
Range on HMM: 2-104/105.0
VRHLHHVSWPDKCIPEVACSVLDLLDDVQTSQQQCG-NAPVLVQCSNGVGRSGTFCVISSVIERLKTE-QVIDVFQVIKRIRVNRPGAVESLTQYVFCYQ
|.|.|. .|||...|| . |.|.||..|........ ..||.|.||.||||.|||.... ....|..| . .|.||..|..|  |||.|....||.|.|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

IIQ
...
all
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 355-590 1e-31 105.0 In-house 33-270 (285) alignment 
Range on Protein: 355-590
Range on HMM: 33-270/285.0
AANKKKNRYGNIVTYDHSRVVLErvngDEDSDYINASFIHGFDGTPRSYIASQGPPPPTFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPEKTE--
 ||   ||| ..   . .||||.    . | ||| ||...       .||..||| | |.  ||.|.....   ..||  |.| |  ||  |.|||    
eanpdlnryadvrcieetrvvlk....nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgev

-TYGGVTV--TLHQTEVFADYVIRTFILFREERAVRRM--VRQFNFTVWPDKGVPQYATAVLAFRRKVRALNPRDAgPVIVHCSAGVGRTGAYIVIDAML
  .|   .  |  . |  |  .. .. .   | |      . . .   |||.  |. |  .. . . |. .||..  |. |||||||||| ... ||   
vkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkek.picvhcsagvgrtatfvgidyat

EQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
 .   |  ... . .  .|  | . ||.. |. |..  ..| .
irimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 485-625 4.4e-31 102.7 In-house 88-229 (440) alignment 
Range on Protein: 485-625
Range on HMM: 88-229/440.0
RRMVRQFNFTVWPDKGVPQYATAVLAFRRKVRALN-PRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIH
 | ..|...  |||||||..|  || . . |   .     ||..||||||.||||  |..|..| .|| .  .|| ... ..|..||.|||| |||.|.|
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvh

SAVLEALTCGNTEIQSENFNQTTQKLASVNRKFQMTGYALEF
 ||||.| ||.| |  ..  .  ...   | . . .    ||
eavlegllcgdtliledditerveqiqwpnphtdksplqqef
PTPc_DSPc_SM00012 488-588 4.7e-31 102.5 In-house 2-105 (105) alignment 
Range on Protein: 488-588
Range on HMM: 2-105/105.0
VRQFNFTVWPDKGVPQYATAVLAFRRKVRALNPRDA--GPVIVHCSAGVGRTGAYIVIDAMLEQAKIN-RTVDIRNYLIALRKDRPHMVQTKEQYSFIHS
|... .| |||.|||......| . |.|.  .   .  .||.||||||||||| ....| .|.| . . ..||| ... .||| ||.||||.|||.|.. 
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AVLE
|.||
alle
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 643-883 9.9e-31 101.6 In-house 42-287 (305) alignment 
Range on Protein: 643-883
Range on HMM: 42-287/305.0
VGEEPQNLQKNRFCDIVALNSCRVMLrkeHADEESDYINAVFLHAHRERNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELD-QEYPQYWPDH-
   | |. .|||. |.  |.  || |   ..    .|| | .. .  . . || || || .|  ||| |  .  . .| || || |   .   .|.. . 
afkeaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskd

-GATKYGHIGVSVLSKQEKGDVIS----TKLEVTR-----KKVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQTSQqqcgnAPVLVQCSNGVGRS
    ..   |  .  | |    ..    .| .||.     .    |.. | | | . |||. .|    ..|.|| . ..|.      |. | || |.||.
kdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpsk.....gpivvhcsagigrt

GTFCVISSVIERLKTEQVID-VFQVIKRIRVNRPGAVESLTQYVFCYQIIQKYL
|.  ..  ....| . |.|.   .....|| .|  .... .||.| .|.| .|.
gsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf
0051082 (Phosphotyrosine protein) phosphatases II 677-879 4.7e-30 99.5 In-house 3-149 (151) alignment 
Range on Protein: 677-879
Range on HMM: 3-149/151.0
SDYINAVFLHAHrernaFIATQHPlletVEDFWRMVTDYDIGTIVMLNNLHELDqEYPQYWPDHGatkyghigvsvlskqekgdvistklevtrkkvrrk
|||||. ..  .     ......|     .||.... ...| |||.|....| .  .|.|.|..|                                   
sdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg.ycpeylpelg...................................

tHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQTsqqqCGNAPVLVQCSNGVGRSGTFCVISSVIERlkteqvIDVFQVIKRIRVNRPGAVESLTQYVFCY
 .||.|.. ..|||  .|.   .||..|. ..     ..| |||| || |.||.||....  ....      ........ .|  |||.| . .|..|..
.ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfql

QII
. .
fal
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 633-881 1.3e-28 94.4 In-house 21-267 (281) alignment 
Range on Protein: 633-881
Range on HMM: 21-267/281.0
SREIPAEEKSVGEEPQNLQKNRFCDIVALNSCRVMLRKE-HADEESDYINAVFLHAHRERNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ
  . |..  .| ..| | .|||. .| .|.  || |. .    . .||| | ....   .  .| || |  ||  |||||. . .  .|||| .. | ..
pgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnr

EY-PQYWPD--HGATKYGHIGVSVLSKQEKGDVISTKLEVTRKkvrRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQTSqqqcgNAPVLVQCSNGVG
|   .|.|   | . .. .. ||      .  ...|.|... .    .|. . |     |||  .|| .  .| .|  ...       .| ...|| |||
ekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsye...getrlithwlwkewpdwqvpessevmlkilrkirar.....stppvihcsagvg

RSGTFCVISSVIERLKTEQ-VIDVFQVIKRIRVN-RPGAVESLTQYVFCYQIIQK
||||.  .   .. ...   . |. |.. ..||  |  .|..| ||.. ....  
rsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 648-883 1.6e-28 94.2 In-house 54-289 (305) alignment 
Range on Protein: 648-883
Range on HMM: 54-289/305.0
QNLQKNRFCDIVALNSCRVMLRKEHadeESDYINAVFLHAHR-ERNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ-EYPQYWPDHGATKY
 .  |||. |. . .   | | |      |||| | .. .     . ||..| || .|...|| || .  .  |||| .  || .    ||||     | 
iaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekl

GHI-GV--SVLSKQeKGDVISTKLEVTRKKVR---RKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQTSQqqcgnAPVLVQCSNGVGRSGTFCVISSV
    |.    .|   |     .....|  ..     ..  ||||.   |||. .| .  . |.||  .. |.      |..|.|| |.||.||   |  .
elksgivvenvsgs.kpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk.....vpivvhcsagigrtgtivaieyi

IERLKTE-QVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKYL
.|..  . ..  . ...| .| .|  ....  ||.| .... .|.
lekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
0044763 (Phosphotyrosine protein) phosphatases II 663-883 3.3e-28 93.9 In-house 4-171 (178) alignment 
Range on Protein: 663-883
Range on HMM: 4-171/178.0
SCRVMLRKEHADEESDYINAVFLHAHrernaFIATQHPLletvEDFWRMVTDYDIGTIVMLNNLHELD-QEYPQYWPDHGAtkyghigvsvlskqekgdv
 .|| | .    | ||||||..   .     ......|     .|..... ...|..||.|..  ||  .....|||.                      
rtrvllsnleglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag...................

istklevtrkkvrrkthevRHLHHVSWPDKCIPEVACSVLDLLDDVQTSQQQCGnAPVLVQCSNGVGRSGTFCVISSVIERlkteQViDVFQVIKRIRVN
                    . .|. .|| . |..   .|.... ... ....|  |||| || |||||||....  ....    .. .....|...|  
...................iqylhipipDhgvpdllehflefvefieealdekg.gpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrer

RPgAVESLTQYVFCYQIIQKYL
|| .|..  |. ..|.. ...|
Rp.ivpnpgqlrqLyefelrll
subfamily_ptpA1_pd Subfamily ptpA1 637-843 3.7e-28 93.4 In-house 35-256 (418) alignment 
Range on Protein: 637-843
Range on HMM: 35-256/418.0
PAEEKSVGEEPQNLQKNRFCDIVALNSCRVMLRKEHADEESDYINAVFLHAHRErNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHE-LDQEYPQ
   | | |.. .|  |||. .|. .|  || |.| .  | |||||| ..      . ||.|| || .|. |||||| .     ||||.   |    .  .
gpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdr

YWPDH-GATKYGHI--GVSVLS--KQEKGDVIS-TKLEVTRKKVR----RKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQTSQQQC-----GNAPVL
|||.. |  ..     |  |.     |  .||   . |.  ...|     .|... . ..  |||. ||. .  . .||  .   |.|       | |..
ywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpii

VQCSNGVGRSGTFCVISSVIERL
|.|| ||||.||||    ....|
vhcsagvgrtgtfctavimmkkl
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 649-883 5.9e-28 92.6 In-house 35-270 (285) alignment 
Range on Protein: 649-883
Range on HMM: 35-270/285.0
NLQKNRFCDIVALNSCRVMLRKeHadeESDYINAVFLHA-HRERNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQEY-PQYWPDHG--ATK
| . ||..|. ...  ||.|.. |   . ||| | ...   ......|.|| || ||. |||.|. .  |  ..||  | |   |    |.|..     |
npdlnryadvrcieetrvvlkn.h...drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvk

YGHIGVSVLSKQEKG--DVISTKLEVTrkKVRRKTHEVRHLHHV---SWPDKCIPEVACSVLDLLDDVQTSQQQcgNAPVLVQCSNGVGRSGTFCVISSV
.|.  ...   .|.     |   | |.  .    . |  .. ||    |||.  || |  ...|   |.  . .  . |. |.|| ||||. ||  |   
fgkyeitlteckeeaiagtilnaltvi..ntedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk..ekpicvhcsagvgrtatfvgidya

IERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKYL
  |.  .  |....... .|  |  ||.|  |..| | .. .|.
tirimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 357-582 3.1e-27 90.1 In-house 50-273 (301) alignment 
Range on Protein: 357-582
Range on HMM: 50-273/301.0
NKKKNRYGNIvTYDHSRVVLERVNGDedSDYINASFIHGFdGTPRSYIASQGPPPPTFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPEKTETY--
.|.|.|| ..   . |  |   |.|      | | .|    | |. .||.||| . | | || |.   . . ||||.. ||  ..||..| | |..    
pkdkhryptv.PckPstavevivdGk..rvPihanwipts.GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekld

-GGVTVTLHQTE-VFADYVIRTFILFRE--ERAVRRMVRQFNFTVWPDKGVPQYATAVLAFRRKVRalnpRDAGPVIVHCSAGVGRTGAYIVIDAMLEQA
 |  .......| .. . ...  .  ..  ..   | |  .... |.|.|||.  . .  .   |.    .   |..||||||.||. |.|  . .  . 
igrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvk....ksekPivvhcsaGiGrsvafigteylarev

KINRTVDIRNYLIALRKDRPHMVQTKEQYSFI
. ..|... . |  ||..| . |||..|  ..
eadptieltealkhlrehrwngvqtnsqlywm
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 680-872 4.1e-27 89.7 In-house 78-270 (301) alignment 
Range on Protein: 680-872
Range on HMM: 78-270/301.0
INAVFLHAHRERNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHE-LDQEYPQYWPDHGATK--YGHIGVSVLSKQE--KGDVISTKLEVTRKKVR
| | .. .. . . ||||| || .| |||| |.. ||. .|||| .  | | .   .| | . . |   |   . . .|.   . ...  .|||.    .
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

RKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQTSQQqcgnaPVLVQCSNGVGRSGTFCVISSVIERLKTEQVIDVFQVIKRIRVNRPGAVESLTQY
 .|. | |  ...|.|. .|.    . ||.. |. |..     |..|.||.|.||| .|     .  ...... |.. . .|..| .|  .|   .| 
fatrtvthyqysewtdrgvPkshaelfdlmelvkksek.....PivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsql
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 648-877 6.6e-27 88.9 In-house 51-284 (310) alignment 
Range on Protein: 648-877
Range on HMM: 51-284/310.0
QNLQKNRFCDIVALNSCRVMLRKEHADeESDYINAVFLHAHRERNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQEY-PQYWPDHGATK-Y
....|||..|.| |...|| |. ...    ||| | ....   |..|| .| ||  |. |||||. .    .|..| .  |  .     |||  | |. |
kymhknrysdvvcldtsrvklkidksr.yedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtety

GHIGVSVLSKQEKGD-V-------ISTKLEVTRKKVRRKTHEVRHLHHVSWPDKCIPEVACSVLDllddvQTSQQQCGNAPVLVQCSNGVGRSGTFCVIS
| | |. ||.  .   .       .  .. |  .    |   |  ..   |||. .|.  |  .      |    |    |..|.|| |..| .. . . 
gcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp.....qrllaqvrhgpcvvhcsagkdrlyvvvalk

SVIERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQ
  |..|.  . .|. .|.  .. .|   ...  ||..  .
lkidkldrglkvdaeevktellksraiciqtelqyliidr
subfamily_egg_pd Subfamily egg 646-882 1.9e-25 84.2 In-house 37-269 (307) alignment 
Range on Protein: 646-882
Range on HMM: 37-269/307.0
EPQNLQKNRFCDIVALNSCRVMLRKEHADEESDYINAVFLHAHRERNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELdQEYPQYWPDHGA--T
.  ||.| |   .   .|.|| |. ..     |.| |  .. .   | || .| || .||.||||||   ..  ||||.   |  .. . |||   .   
sdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes.erceyywpkaesdsl

K--YGHIGVSVLSKQEKGDVIstkLEVTRKKVRRKTHEVRHLHHVSWPDKCIPEVAcSVLDLLDDVQTSqqqcgNAPVLVQCSNGVGRSGTFCVISSVIE
.   | . .  |  ..| | .   . ||. |.    .| |.| |  .  .   .|  | | .|  ..         ||.||. .|| ...|.  |   . 
vtvpGslrienlkvdskadpl...frvtklklvGgddeerflehwqgdvnnssdvy.splrvlrklrnl.....skpvvvqdilGvskaatlvaieiall

RLKTEQV--IDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKY
 |    .    | . .. .| .|. .|||  .|.| |...  .
sllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlff
0048076 (Phosphotyrosine protein) phosphatases II 455-587 1.3e-24 81.9 In-house 14-140 (145) alignment 
Range on Protein: 455-587
Range on HMM: 14-140/145.0
GGVTvTLHQTEVFADYVIRT-FILFREERAVRRMVRQFNFTVWPDKGVPQYATAVLAFRRKVRALNPRDaGPVIVHCSAGVGRTGAYIVIDAMLEqakin
|... | .. | ..|. |.| . | .|.. . |.. |. .. ||| |||. .  .|.| . .... ... |||.|||||||||||...... ||.     
gslp.taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll.....

RTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVL
. |.. . |  .|. ||..|.. .|. |.. ..|
lgvsleealelvrsqrpgavpnpgqlrflyefel
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 648-882 2.2e-24 80.4 In-house 50-284 (302) alignment 
Range on Protein: 648-882
Range on HMM: 50-284/302.0
QNLQKNRFCDIVALNSCRVMLRKehadEESDYINAVFLHAHRERNAFIATQHPLLETV---EDFWRMVTDYDIGTIVMLNNLHELDQEYPQYWP-DHGA-
.||.||.  |. .|.| .| | .    |. .|.||  ..    ..  | .| | ....   |.||||| .  | ..|.|    ||..   ...|   |. 
knlkknqsedvpildsnlvklea....epdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgdy

TKYGHIGVSVLSKQ-EKGDVISTKLEVTRKKVRRKT-HEVRHlhHVSWPDKCIPEVACSVLDLLDDVqTSQQQCGNAPVLVQCSNGVGRSGTFCVISSVI
..||.. | .   .  ....    .||  . .      .| .  .  |..| .|.   ..     .|   ... .......   ||.|| |.| .   ..
keygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyv..ltnWkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGRagafltlavav

ERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKY
|.|....   . ...| || .|| ||.||.|||. | ..  |
eklqkgkepnikeivksiRsqRpravdslkQyvslyiallly
subfamily_egg_pd Subfamily egg 327-587 4.8e-23 76.3 In-house 15-267 (307) alignment 
Range on Protein: 327-587
Range on HMM: 15-267/307.0
QANRgiRLEAeYKNVSNEQQFSwdAARKAANKKKNRYGNIVTYDHSRVVLERVNGDEDSDYINASFIHGFDgTPRSYIASQGPPPPTFEGFWRMVWEQNS
. .|  |||   .....|. .    | .. |..| |   .   | ||| ||  .|    |.| |  ..|       .| .| |   | . |||||.... 
eler..rlev.leesvdeislt..taasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkp.llnefilaqaplkntvddfwrmvfqeev

QSIVMLTNLVELgkTKCHKYWPEKTE-T----YGGVTVTLHQTEVFADYVIRTfilfREERAVRRMVRQFNFTVWpdKGVPQYATAVLAFRRKVRALNpR
| |||||  .|    .|. |||   . .     |.. ..  . .  || . |      . . |     .     |  .|  .... |    | .| |  .
qyivmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrv....tklklvGgddeerflehw..qgdvnnssdvysplrvlrklr.n

DAGPVIVHCSAGVGRTGAYIVIDAMLEQA---KINRtVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVL
 . ||.|..  || .... . |.  | .     | .   ...    ||. |.  |..  .| |..  ||
lskpvvvqdilGvskaatlvaieiallsllrGpitk.slvlravvflrlrrrlsvesvllylfvyrlvl
0048179 (Phosphotyrosine protein) phosphatases II 467-584 6.6e-23 76.5 In-house 25-139 (144) alignment 
Range on Protein: 467-584
Range on HMM: 25-139/144.0
FADYVIRTFILFREE---RAVRRMVRQFNFTVWPDKGVPQYATAVLAFRRKVRALNPRDaGPVIVHCSAGVGRTGAYIVIDAMLeqakiNRTVDIRNYLI
.... |.| | ..||     . |.. |. .. ||| |||.... .|.| . .... ... |||.|||||||||||...... |.      . ... . | 
lkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk.....klglsleeala

ALRKDRPHMVQTKEQYSFIHS
 .|. ||..|.. .|. |.. 
lvrsrrpgavpnpgqlrfLle
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 401-583 3.3e-22 73.6 In-house 5-197 (199) alignment 
Range on Protein: 401-583
Range on HMM: 5-197/199.0
RSYIASQGPPPPTFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPE---KTETYGGVTVTLHQTEVFADYVIRTFILFREERA--VRRMVRQFNFTV
| |||.| |   |.  ||.||||  |  |||. .     ..    |||     |  || ..|| .   . .||.| ..||  .  |    | . ...|| 
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDKGVPQYAT---AVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKINRT--VDIRNYLIALRKDRPHMVQTKEQYSFIH
| .|  |. |     |.| |   .  .     ||||||| | | || .. .|  .   .  .|  ||. .    ||. |  .. . ..| ||.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 401-583 3.5e-22 73.5 In-house 4-196 (198) alignment 
Range on Protein: 401-583
Range on HMM: 4-196/198.0
RSYIASQGPPPPTFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPE---KTETYGGVTVTLHQTEVFADYVIRTFILFREERA--VRRMVRQFNFTV
| |||.| |   |.  ||.||||  |  |||. .     ..    |||     |  || ..|| .   . .||.| ..||  .  |    | . ...|| 
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDKGVPQYAT---AVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKINRT--VDIRNYLIALRKDRPHMVQTKEQYSFIH
| .|  |. |     |.| |   .  .     ||||||| | | || .. .|  .   .  .|  ||. .    ||. |  .. . ..| ||.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 358-463 5e-22 73.1 In-house 48-164 (350) alignment 
Range on Protein: 358-463
Range on HMM: 48-164/350.0
KKKNRYGNIVTYDHSRVVLER--------VNGDEDSDYINASFIHGF----DGTPRS-YIASQGPPPPTFEGFWRMVWEQNSQSIVMLTNLVELGKTKCH
  |||| ||. |.|||| |..            . .|||||....      .  |   ||| |.| | |.. |.... . . . |..||..|||.  ||.
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

KYWPEKteTYGGVTVTLHQ
.||.|   .| ..|| | .
rYWqeg..sydditvklas
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 413-590 3.8e-21 70.3 In-house 40-221 (255) alignment 
Range on Protein: 413-590
Range on HMM: 40-221/255.0
TFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP-EKTETYGGVTVTLHQTEVFADYVIRTFILFRE--ERAVRRMVRQFNFTVWPDKGVPQYATAVL
| . |....  .... .|||... | |. ||..|.| || |      |..  |.  || |.||  .  .  |.   . |. .... |..|  |. |  .|
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

AFRRKVRalnprDAGPVIVHCSAGVGRTGAYIVIDAMLE----QAKINRTVDI--RNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
   . ||     |. .|.||||.|.||. |..... .      . .   ||..  .. |  ||. |.  ..|  | .|    ||. .
nilkvvr.....dsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 696-880 6.6e-21 69.5 In-house 39-218 (255) alignment 
Range on Protein: 696-880
Range on HMM: 39-218/255.0
AtqhplleTVEDFWRMVTDYDIGTIVMLNNLHELD-QEYPQYWPDHGATKYGHIGVSVLSKQEKGDVISTKLEVTRKKV-RRKTHEVRHLHHVSWPDKCI
        ||. |....   .  ..||| ...| . ..  .|.|     |     |.| . .   ||.   ||.| .   ..|||.|.| ..  |..|  
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWiekna

PEVACSVLDLLDDVQTSQqqcgnaPVLVQCSNGVGRSGTFCVISSVIE----RLKTEQV--IDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQ
|| |  .| .|  |. |.      .|.|.||.|.||| .| .. .|       |.| .   .|  .... .| .|..|..   |  |.  .. 
Pelareilnilkvvrdsk......svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvl
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 332-587 7.8e-21 68.8 In-house 26-282 (302) alignment 
Range on Protein: 332-587
Range on HMM: 26-282/302.0
IRLEAEYKNVSNEQQfSWDA-ARKAANKKKNRYGNIVTYDHSRVVLERvngdEDSDYINASFIHGFDGTpRSYIASQGPPPPTF---EGFWRMVWEQNSQ
.....|.|.... .  . .      .| |||.  ..  .|. .| ||     |  .|.||| ..  . | || | .| |   .    | |||||.... .
aevkkefkkidtmkv.dlekCkafkknlkknqsedvpildsnlvklea....epdsyvnaskvevPelt.rsiilaQlpkvdsedsveeFWrmvfqekiv

SIVMLTNLVELGKtKCHKYWPEKTE---TYGGVTVTLHQTEVFADYVIRTF-ILFREERAVRRMVRQFNFTVWPDKGVPQYATAVLAFRRKVRALNPRDA
|.|.|    || |   ....|.|..   .|| . |   . |   . . |    .. |. .   ..    .| |..| ||.  ... .   || |..    
svvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikad

GPVIVHCSAGVGRTGAYIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVL
 ....    |.|| || ..  . .|. . .  . | . ....|..||..|.. .|| ... |.|
entvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiall
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 699-882 2.4e-20 67.2 In-house 98-287 (302) alignment 
Range on Protein: 699-882
Range on HMM: 98-287/302.0
HPLLETVEDFWRMVTDYDIGTIVMLNNLHELD-QEYPQYWPDH--GATKYGHIGVSVLSKQE-------KGDVISTKLEVTRKKVRRKT-HEVRHLHHVS
 |  .|.| .| .. .|... .| | .. | . . . .|. |.  |  |.|.  |  .| ..       | ..   ..|.. .|...|. . |  |.. .
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPDKCIPEVACSVLDLLDDVQTSQQQcgnapVLVQCSNGVGRSGTFCVISSVIERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKY
|||.  |. | . ||.|   .. ...     ||| ||.||||.||.  |   |.  ....| |. .... .|  | ||| . .| ..   .. | 
wpdhGapkeaytaldilkfcesykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkg
0048076 (Phosphotyrosine protein) phosphatases II 770-882 4.3e-20 67.3 In-house 37-142 (145) alignment 
Range on Protein: 770-882
Range on HMM: 37-142/145.0
RKKVRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQTSQQQcgNAPVLVQCSNGVGRSGTFCVISSVIErlktEQvIDVFQVIKRIRVNRPGAVESL
    .  .... ......||| ..|. .  .|..|. ... ...  . |||| || ||||.||....  ...    .. ..........|  |||||.. 
tselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqrpgavpnp

TQYVFCYQIIQKY
 |. |.|. ....
gqlrflyefelel
0048179 (Phosphotyrosine protein) phosphatases II 764-877 5.9e-20 66.9 In-house 48-139 (144) alignment 
Range on Protein: 764-877
Range on HMM: 48-139/144.0
TklevtrkkvrrktheVRHLHHVSWPDKCIPEVACSVLDLLDDVQTSQQqcGNAPVLVQCSNGVGRSGTFCVISsvieRLKTEQvIDVFQVIKRIRVNRP
.               . ...|..||| ..|. .  .|..|. ... ..   . |||| || ||||.||....     ..|... ..........|  ||
e...............giqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaay....lmkklg.lsleealalvrsrrp

GAVESLTQYVFCYQ
|||..  |. |...
gavpnpgqlrfLle
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 653-889 2e-19 64.5 In-house 47-282 (312) alignment 
Range on Protein: 653-889
Range on HMM: 47-282/312.0
NRFCDIVALNSCRVMLrkehADEESDYINAVFLHAHRERNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQEY-PQYWPDHG-AT------K
||. .|   .  |  |    | .|  || | |..     . |..|| || .|.  ||...      .|..|  . |   |   .|  |            
nrypniqcwdrgrftl....agdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrv

YGHIGVSVL-SKQEKGDVISTKLEVTRKKvRRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQTSQQqcgnaPVLVQCSNGVGRSGTFCVISSVIERL
|      .    . |  .    | |  |    .   . |    ||||. .|.   . | ||  |.  ..     ||. .|| ||||.||...| |.|  |
yteycteieiggkskdkithrvlkvvvka.tgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk.....pviahcsagvgrtgtlaliesmiaal

KTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKYLGSFSDY
.  .  .| ..   .| .|  .|. . |||.. ... ..| | . |
rhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskgly
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 648-882 2.1e-19 64.3 In-house 46-278 (303) alignment 
Range on Protein: 648-882
Range on HMM: 46-278/303.0
QNLQKNRFCDIVALNSCRVMLrkehadEESDYINAVFLHAHRERNAfIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQE-----YPQYwPDHGA
.|..||||.|.. |.  .| |       .| || | .|. . ...| | || ||  |  |||.|. .  .  ...|    | |.      .|.   |   
knmdknrfvdvicldhskvkl......sdssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprn.qdflk

TKYGHIGVSVLSKQEKGDVISTKLeVTRKKVRRKTheVRHLHHV-SWPDKCIPEV-ACSVLDLLDDVQTSQQQCG-NAPVLVQCSNGVGRSGTFCVISSV
 .   | |  . . | ||  . |. ..  .   |.    |.||  .|| . ||   .  ..  . ..|.  ..   . | .     |.||.|||... . 
feersirvgefkrvelgdgwvlkv.lsvsngdyks..flhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfeta

IERLKTEQV-IDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKY
   |..||  .|. .... .|  |  ||. |.|. . | .. ..
hlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaeh
subfamily_CG42327_pd Subfamily CG42327 650-810 3e-19 63.8 In-house 29-193 (319) alignment 
Range on Protein: 650-810
Range on HMM: 29-193/319.0
LQKNRFCDIVALNSCRVMLRKEHADEESDYINAVFLHAHRE-RNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELD-QEYPQYWPDH----GAT
 .|.|. ..| |   ||.|..   |... |..| ..  ... .| .||.| .| ..  ||||.| .    .|| | .|.||  .  ..|.| .    .  
kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnts

KYGHIGVSvLSKQEKGDVISTKLEVTRKKVRRKTHEVRHLHHvSWPDKCIPEVACSVLDLLDDVQTS
 ||.| |. | ..| .|   .   . ..  . .. |. |  .  |..  .|    ... .| .|..|
lyGdilvt.lkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
subfamily_hpo-7_pd Subfamily hpo-7 414-608 5e-19 63.2 In-house 47-245 (263) alignment 
Range on Protein: 414-608
Range on HMM: 47-245/263.0
FEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP-EKTETYGGVTVTLHQTEVFADYVIRTFILFR--EERAVRRMVRQFNFTVWPDKGVPQYATAVLA
 . |....  .... .|||..  | |. || .|.| || |      |..  |.|  | ...|  |    .|.   . |... .. |..|  |. |  .| 
idkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelareiln

FRRKVRalnprDAGPVIVHCSAGVGRTGAYIVIDAMLE----QAKINRTVDI--RNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENFNQ
  . .|     .  ...||||.|.||. |. |.. .      . .   ||..  .. |  ||. |.  ..|  | .|    ||. .   ... . |   |
ilkvar.....nskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfakgeleakyq

TTQK
  .|
eirk
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 661-879 6.3e-19 63.2 In-house 30-255 (290) alignment 
Range on Protein: 661-879
Range on HMM: 30-255/290.0
LNSCRVMLRKEHADEESDYINAVFLHAHrERNAFIATQHPLLET-------VEDFWRMVTDYDIGTIVMLNNLHELDQEYP-----QYWPDHGA--TKYG
..  ||.|.       .||| | ..    .  ..|.|| |. ..       .|.|| |. .  .  .||| . .| ...       .| |..     |..
veatrvvLkgygkrfnddyiHAnrvtcp.nglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfk

HIGVSVLSKQEKGDVISTKLEVTRKKvrRKTHEVRHLHHVSWPDKCIPEVACSVLDLLDDVQTSqqqcgNAPVLVQCSNGVGRSGTFCVISSVIERLK-T
 . |.  || .. ||.  .|.|.  .  .. . | |   ..| .  ..|   ..|.|.. |..|     ..||.| | .|. || ..  |      .  |
gltvkCkskekeddvetRelvvkfdd..eeeftvtHsllkgWnklnvqedtktllsliqkvkas.....ktpvivHcvdGiSrsAalaaiilgyQkiaet

EQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQII
.. . . .|.| .| .|  |. | ... |    |
sgsvkledvlkalrkqralaitsalelafvdagi
subfamily_hpo-7_pd Subfamily hpo-7 696-879 7.9e-19 62.6 In-house 42-223 (263) alignment 
Range on Protein: 696-879
Range on HMM: 42-223/263.0
AtqhpLLETVEDFWRMVTDYDIGTIVMLNNLHELD-QEYPQYWPDHGATKYGHIGVSVLSKQEKGDVISTKLEVTRK--KvRRKTHEVRHLHHVSWPDKC
     |..|.. |....      ..||| . .| . ..  .|.|     |     |.| . . . ||.   ||..    . ..|||.|.|  .. |..| 
l....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlge.KkkthtvkhysykgWiekn

IPEVACSVLDLLDDVQTSQqqcgnaPVLVQCSNGVGRSGTFCVISSVIE----RLKTEQV--IDVFQVIKRIRVNRPGAVESLTQYVFCYQII
 || | ..| .|. .. |.      .. | ||.|.|||  | |. .|       |.| .   .|  .... .| .|..|..   |  |   ..
dpelareilnilkvarnsk......slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmv
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 636-752 4.3e-18 60.1 In-house 34-162 (350) alignment 
Range on Protein: 636-752
Range on HMM: 34-162/350.0
IPAEEKSVGEEPQNLQKNRFCDIVALNSCRVMLR--------KEHADEESDYINAVFLHAH----RERNAF--IATQHPLLETVEDFWRMVTDYDIGTIV
 | ..  . |  .   |||. .|.  .  || |.        |.|. . .||||| .|.      .    |  |||| || .||.||.....  ..  |.
spsnDvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvil

MLNNLHELDQE-YPQYWPDHGatkYGHIGVSV
.|... ||. | . .||.. .   |  | | .
sltsdvelnlekcyrYWqegs...ydditvkl
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 359-602 5.4e-18 60.1 In-house 21-272 (290) alignment 
Range on Protein: 359-602
Range on HMM: 21-272/290.0
KKNRYGNiVTYDHSRVVLERVNGDEDSDYINASFIHGFDGTprSYIASQGPPPP-------TFEGFWRMVWEQNSQSIVMLTNLVELGKT----KCHKYW
...|. .     ..||||.       .||| |...   .|     |..| |          | | || |. . .....||| .  |  .      | || 
mdqRlev.pLveatrvvLkgygkrfnddyiHAnrvtcpngl..rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYv

PEKTE---TYGGVTVTLHQTEVFADYVIRTFILfREERAVRRMVRQFNFTVWPDKGVPQYATAVLAFRRKVRalnpRDAGPVIVHCSAGVGRTGAYIVID
||. .   ...|.||   . |   |  .|. .. . .  .   |    .  | .  |..    .|.  .||.        ||||||  |. |  |   |.
pesvgeelkfkgltvkCkskekeddvetRelvv.kfddeeeftvtHsllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGiSrsAalaaii

AML-EQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVL-EALTCGNTEIQSENF
      |. .  | ... | |||| | ..........|.  ...  |   ... ...|. 
lgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllaievldqfaeeete
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 397-590 4e-17 56.6 In-house 84-288 (302) alignment 
Range on Protein: 397-590
Range on HMM: 84-288/302.0
DGTPRSYIASQG---PPPPTFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPEKTE---TYGGVTVTLHQ----TEVFADYviRTFILF-------R
||| .    |.    |   | | .| .. . |   .| |...|| .. || .|. .| .   ..|  ||.  .     | |.|   ..| |.       .
dGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdk..ksfklytveiknek

EERAVRRMVRQFNFTVWPDKGVPQYATAVLAFRRKVRALNPRdagpVIVHCSAGVGRTGAYIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQY
 ...|.. |  . |. |||.| |. | . |   .   .        |.|||||||||||. . |   ..  . ... |. . .. .|. |   ||...| 
kkkkvkktvdilafsawpdhGapkeaytaldilkfcesykkn....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqql

SFIHSAVLEAL
 ..   |  .|
iylllcvtkgl
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 527-593 1.4e-16 54.6 In-house 2-68 (69) alignment 
Range on Protein: 527-593
Range on HMM: 2-68/69.0
IVHCSAGVGRTGAYIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCG
.||||.| ||||..| |   . . | .. ||| | .  .|| || ||  . .| ||| |. |||  |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 527-593 2e-16 54.1 In-house 1-67 (69) alignment 
Range on Protein: 527-593
Range on HMM: 1-67/69.0
IVHCSAGVGRTGAYIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCG
.||||.| ||||..| |   . . | .. ||| | .  .|| || ||  ...| ||| |. |||  |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 514-590 2.5e-16 54.4 In-house 220-295 (297) alignment 
Range on Protein: 514-590
Range on HMM: 220-295/297.0
KVRALNPRDAgPVIVHCSAGVGRTGAYIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
 .||  ||.| ...|||||||||.|  .  |..|.. . .|  |..  |  ||. |. .||| ||. ....|||. |
slraemprna.yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_CG42327_pd Subfamily CG42327 521-585 2.5e-16 54.2 In-house 245-310 (319) alignment 
Range on Protein: 521-585
Range on HMM: 245-310/319.0
RDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKIN-RTVDIRNYLIALRKDRPHMVQTKEQYSFIHSA
 . ||..|||| ||||||  |  |  ... . . |.||| . .  .|.|| . |.||||| ||.  
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv
subfamily_eak_pd Subfamily eak 348-515 2.8e-16 53.8 In-house 43-207 (332) alignment 
Range on Protein: 348-515
Range on HMM: 43-207/332.0
SWDAARKAANKKKNrYGNIVTYDHSRVVLERVNGDEDsDYINASFIhGFDGTPRSYIASQGPPPPTFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYW
|   ...  . ..|   .|| ||.  | |     ...  ||||| .  |    | || .  .       ||.|| ||.| .||.| . |||.  |  ||.
sisetarleavnrn.vvkivpydrylvrltssqlnrl.Gyinasla.efsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyf

PEKT---ETYGGVTVTLHQTEVFADYVIRTFILFREERAVRrmVRQFNFTVWPDKGVPQYAtAVLAFRRKV
|.||     .| . |.  .    . .  | ..| . . . |  |  ...  | .  .|.|    ||.|. .
pdktreelkfGildverkefvkrniletrllelskGnethr..vlhykvfGwtettlpkye.dflalrkvm
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 312-397 1.2e-15 51.8 In-house 4-87 (440) alignment 
Range on Protein: 312-397
Range on HMM: 4-87/440.0
KPISVAHFPKYVAIMQanRGIRLEAEYKNVSNEQQFSWDAARKAANKKKNRYGNIVTYDHSRVVLERVNGDEDSDYINASFIHGFD
.|| || |  ||   .  |    | |.  . .  .   | |    || |||| ||..||||||.|| |.|  ||||||||.| | .
rpiivadfadyvqnnr..rsrafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingie
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 312-408 5.1e-15 49.4 In-house 3-95 (95) alignment 
Range on Protein: 312-408
Range on HMM: 3-95/95.0
KPISVAHFPKYVAIMQANRGIRLEAEYKNVSNEQQFSWDAARKAANKKKNRYGNIVTYDHSRVVLErvnGDEDSDYINASFIHGFDGtPRSYIASQG
||| |. |  .|  |..|    .. |.| .|     .. .    ||  |||. ||. || .||||       ||||||| |. |.      |||.||
kpihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlt...tkrdsdyinacfvdgyar.kncyiaaqg
fn3 Fibronectin type III domain 1-78 3.9e-14 45.7 Pfam-A 2-79 (85) alignment 
Range on Protein: 1-78
Range on HMM: 2-79/85.0
APTSLSTTVLTSTSIRVTWSALPgtCTNGIVRKYVISYHKNGGSDETTEINAPRTS--FDISDLEKYTEYTIKVCGYTVK
||. || .  ||||....||. .    .| . .| . | . ||..|..|...|||.  . ...|. .|||...|  .. .
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavnga
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 583-769 6.7e-14 46.1 In-house 32-212 (244) alignment 
Range on Protein: 583-769
Range on HMM: 32-212/244.0
HSAVLEALTCGNTEIQSENFNQTTQKLASVNRKFQMTGYAlEFQRLNSFTSREIPAEEKSVgEEPQNLQKNRFCDIVALNSCRVMLRKEHAdeESDYINA
 .||| | .. |  |.   |..|   |.| ...      | .. . .    |  |.  | .  .|.|  |||    . ..  || | |        ||||
tnavlsanatknryinilpfdetrvilssskkegsdyina.nyiqgsqniirpdpsvmkda.fnpnnswknregaglpfdfnrvplskgsm..gntyina

VFLHAHRERNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDqeypQYWPDHGATKY--GHIGVSVLSKQEKGDVISTKLEVT
 |.        .| ||||| .|  |||.|. .  .  .|.|  . | |    .||||    ..    | |..  ..|  .. ...||. 
sfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed....eywpdseplewyeeditvtltdrdefknikasnleie
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 691-883 9e-14 44.8 In-house 114-309 (346) alignment 
Range on Protein: 691-883
Range on HMM: 114-309/346.0
RNAFIATQHPLLE---TVEDFWRMVTDYDIGTIVMLNNLHELDQEYPQYWPDHGaTKYGHIGVS---VLSKQEKGDVISTKLEVTRKKVrRKTHEVRHLH
 . .| .| | .|    ||||| |. . .|  . ..     | .     . |     | . |         .  ||     .||  .     .  ..  |
ehklivaqlpqmenesfvedfwymiyqeqihlvylmvpddklkntttslfnden.ggyqytgkmfinnrradvsgdpkeytievlpegn.sdsvicqvhh

HVSWPDKCIPEVACSVLDLLDDVQtSQQQCGNAPVLVQCSNGVGRSGTFCVISSVIERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKYL
|  |     |  .  .. .. .   |..|  || | |    | ||. .|      |..|      ......| |. .|||.|||..||   | |.  |.
hapwkhlqqppktlpiikmihqfl.sekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyi
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 354-589 1.3e-13 45.2 In-house 44-278 (303) alignment 
Range on Protein: 354-589
Range on HMM: 44-278/303.0
KAANKKKNRYGNIVTYDHSRVVLervngdEDSDYINASFIHgFDGTpRSYIASQGPPPPTFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPEKTET
   | .|||. ...  |||.| |       || || ||... .| . .  | .| | . |   ||.|. ||. . ...|    |  |   .  .|.. . 
fvknmdknrfvdvicldhskvkl......sdssyihasyle.ldss.kkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdf

YG----GVT-VTLHQTEVFADYVIRTFILfrEERAVRRMVRQFNFTVWPDKGVPQY-----ATAVLAFRRKVRALnpRDAGPVIVHCSAGVGRTGAYIVI
       .    ... |.   .|..   .   .   . ..    .  || . .|          .   .  .|     |. | .    .|.||.|.. ..
lkfeersirvgefkrvelgdgwvlkvlsv..sngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrky..sdstptvymslsgcgragtfalf

D-AMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
. | |   . . ..|. . |  .|. | | ||   |.|.... . | 
etahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaeh
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 358-465 2.4e-13 44.2 In-house 49-169 (349) alignment 
Range on Protein: 358-465
Range on HMM: 49-169/349.0
KKKNRYGNIVTYDHSRVVLERVN--------------GDEDSDYINASFIHGFDGTP-RSYIASQGPPPPTFEGFWRMVWEQNSQSIVMLTNLVELGKTK
  |||| .|. |.||||.|..                .    ||||| ...    .. . ||| | | | | . |....  .. . .. |..  ||.  |
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslek

CHKYWPEKteTYGGVTVTLHQTE
|..|| |   .| ..|| |  . 
cdiywqel..sysnitvklqnss
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 522-587 1e-12 42.5 In-house 261-341 (350) alignment 
Range on Protein: 522-587
Range on HMM: 261-341/350.0
DAGPVIVHCSAGVGRTGAYIVIDAMLE-----------QAKI---NRTVDI-RNYLIALRKDRPHMVQTKEQYSFIHSAVL
 . |..||||||||||| .. .| .|.             |.   ..| |.    .  ||| |  |||...|. ||. |.|
rsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeall
subfamily_CG42327_pd Subfamily CG42327 810-882 3e-12 40.8 In-house 241-314 (319) alignment 
Range on Protein: 810-882
Range on HMM: 241-314/319.0
SQQQCGNAPVLVQCSNGVGRSGTFCVISSVIERLKTE-QVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKY
| ..  . |. | ||.||||.|.       |..|..  . .|. |..  .| .|  || .  || | |.....|
sgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
fn3 Fibronectin type III domain 98-185 5.6e-12 38.8 Pfam-A 2-85 (85) alignment 
Range on Protein: 98-185
Range on HMM: 2-85/85.0
SPSAVSHSEINSTTFNISWSSIPkdQRNGIITSYDLELSSGQARRrrWSIPESFTSTLTYIVLHNLESCTIYHLRVRARTGKGPGPYS
.|. .| ||..||....|||  .  ...| ||.|..|... .  .  ..   . ..| |  .|..|.  | |..||.|..|.| ||.|
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekggge..ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_eak_pd Subfamily eak 634-796 8e-12 39.2 In-house 37-197 (332) alignment 
Range on Protein: 634-796
Range on HMM: 37-197/332.0
REIPAEEKSVGEEPQNLQKNrFCDIVALNSCRVMLRKEHADeESDYINAVFLHAHRERNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELD-QE
.  ..  .|...  .....|   .||  .   | |     . .  ||||  .      . .| |  .  . |  ||.|| .    .||.| .  ||. ..
dyqrllsisetarleavnrn.vvkivpydrylvrltssqln.rlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelklek

YPQYWPDHG--ATKYGHIGVSVLSKQEKGDVISTKLEVtrkKVRRKTHEVRHLHHVSWPDKCIPEV
. .|.||..    |.|.. |   .  ... .   .||.   ..  .||.| | .   | .  .| .
sdkyfpdktreelkfGildverkefvkrniletrllel...skGnethrvlhykvfGwtettlpky
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 346-455 5.8e-11 35.6 In-house 16-92 (169) alignment 
Range on Protein: 346-455
Range on HMM: 16-92/169.0
QFSWDAARKAANKKKNRYGNIVTYDHSRVVLERVNGDEDSDYINAsfihgfdgtprsyiasqgpppptfegfwRMVWEQNSQSIVMLTNLvelgkTKCHK
..    |  ..|. |||    ..  | || |.||  |  ||||||                            ||.|| |.  ||.| .           
eynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlgdt.....ddknn

YWPEKTETYG
.|||| .   
fwpekedyql
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 645-722 8.7e-11 35.9 In-house 33-115 (347) alignment 
Range on Protein: 645-722
Range on HMM: 33-115/347.0
EEPQNLQKNRFCDIVALNSCRVMLRKE-----HADEESDYINAVFLHAHRERNAFIATQHPLLETVEDFWRMVTDYDIGTIVM
|  ..|.|||  |    .. ||.|  |     .||.   ||||  ..    .. .| ||.|| .|| |||.||.   .  .| 
ewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 347-454 9.1e-11 34.9 In-house 16-90 (169) alignment 
Range on Protein: 347-454
Range on HMM: 16-90/169.0
FSWDAARKAANKKKNRYGNIVTYDHSRVVLERVNGDEDSDYINAsfihgfdgtprsyiasqgpppptfegfwRMVWEQNSQSIVMLTNLvelgkTKCHKY
.    |  ..|. |||    ..  | || |.||  |  ||||||                            ||.|| |.  ||.| .           .
ynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlGdt.....ddknnf

WPEKTETY
|||| .  
wpekedyq
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 351-498 1e-10 35.7 In-house 90-232 (244) alignment 
Range on Protein: 351-498
Range on HMM: 90-232/244.0
AARKAANKKKNRYGNIVTYDHSRVVLERvnGDEDSDYINASFIhGFDGTPRSYIASQGPPPPTFEGFWRMVWEQNSQSIVMLTNLVElgktkCHKYWPE-
 | .  |  ||| |  . .| .|| | .  |     ||||||. |  |    || .| |   |   ||.|. |.  . .|.|  . |       .|||. 
dafnpnnswknregaglpfdfnrvplsk..gsmgntyinasfv.gclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsvee.....edeywpds

-KTETYG-GVTVTLHQTEVFADYVIRTFILFREERAVRRMVRQFNFTVWPD
   | |   .|||| . . | .     . .  .     . .  |. . || 
eplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwps
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 820-877 1.4e-10 35.4 In-house 2-59 (69) alignment 
Range on Protein: 820-877
Range on HMM: 2-59/69.0
LVQCSNGVGRSGTFCVISSVIERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQ
.|.|| | ||.|||  |   . |.|.|...|.|  .. .|  ||  |    .|.| . 
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihd
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 676-789 2e-10 35.1 In-house 12-122 (130) alignment 
Range on Protein: 676-789
Range on HMM: 12-122/130.0
ESDYINAVFLHAHRERNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDqeypQYWPDHGATK-Y-GHIGVSVLSKQEKGDVISTKLEVTRKkV
. .|||| |.      . .. ||||| .|  |||.|. .  .  .|.|  . | |    .||||    . |  .| |..  ..|   . ...||. .. .
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed....eywpdsePlewyeediivtltdrdefknikasnleiesd.l

RRKTHEVRHLHHVSWP
 .  . .  ..   ||
neshqaltmfqisnwp
subfamily_eak_pd Subfamily eak 523-598 2.8e-10 34.1 In-house 237-313 (332) alignment 
Range on Protein: 523-598
Range on HMM: 237-313/332.0
AGPvIVHCSAGVGRTGAYIVIDAMLE--QAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQ
  | |. .. |  |.|...||| ...  ..|.. .  . ....  .. | | | .. |.|||. .||. |   | ...
fap.iiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnrlr
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 821-878 5.4e-10 33.5 In-house 2-59 (69) alignment 
Range on Protein: 821-878
Range on HMM: 2-59/69.0
VQCSNGVGRSGTFCVISSVIERLKTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQI
|.|| | ||.|||  |   . |.|.|...|.|  .. .|  ||  |    .|.| .. 
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihda
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 757-882 9.1e-10 32.8 In-house 200-343 (350) alignment 
Range on Protein: 757-882
Range on HMM: 200-343/350.0
EKGDVISTKLEVTRkkvrrkTHEVRHLHHVSWPDK---CIPEVACSVLD----LLDDVQTS--QQQCGNAPVLVQCSNGVGRSGTFCVISSVIE---RLK
....... .| ..        ..| .|.   |.|      ||   ..|.    |.||  .    ..   .|.|| || |||| ||.. . |...    |.
dnnsltaitlaasd......PyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeile

---T--------EQVID-VFQVIKRIRVNRPGAVESLTQYVFCYQIIQKY
             .. | ........|  |   | .|.|..|.|. .. |
nltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfy
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 640-739 8.2e-09 29.2 In-house 39-155 (349) alignment 
Range on Protein: 640-739
Range on HMM: 39-155/349.0
EKSVGEEPQNLQKNRFCDIVALNSCRVMLRKE--------HADEE------SDYINAVFLHAHRE--RNAFIATQHPLLETVEDFWRMVTDYDIGTIVML
.  . |  .   |||. ||.  .  ||.|.|         ..  |       ||||| .|.  |    . .|||| ||  ||.||.....   .  .. |
dvilseGvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsL

NNLHELDQEY-PQYWPD
|. .||. |   .|| .
nddkelslekcdiywqe
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 356-431 1.2e-08 28.9 In-house 36-115 (347) alignment 
Range on Protein: 356-431
Range on HMM: 36-115/347.0
ANKKKNRYGNIVTYDHSRVVLER-----VNGDEDSDYINASFIHgFDGTPRSYIASQGPPPPTFEGFWRMVWEQNSQSIVM
 . .|||  .    | .||||        . |.   ||||| |. || . . || .| | | |   ||.||   .   .| 
kslsknrskdvklidatrvvlspeksknsraddvetyinashik.fdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 641-698 2.6e-08 27.9 In-house 40-94 (95) alignment 
Range on Protein: 641-698
Range on HMM: 40-94/95.0
KSVGEEPQNLQKNRFCDIVALNSCRVMLRKEhadEESDYINAVFLHAHRERNAFIATQ
 .||    |. |||| .|.  .. ||.|       .||||||.|.  .  .|..||.|
ytvgsseanipknrflnifpydatrvvlttk...rdsdyinacfvdgyarkncyiaaq
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 522-588 2.8e-08 27.5 In-house 264-342 (349) alignment 
Range on Protein: 522-588
Range on HMM: 264-342/349.0
DAGPVIVHCSAGVGRTGAYIVIDAMLE--------QAKI---NRTVDIRNYLI-ALRKDRPHMVQTKEQYSFIHSAVLE
.  ...|||||| |||| .. .| .|.          ||   . . |.  . .  ||| |  |||   |. .|. |.|.
qlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLk
subfamily_PTPDC1_pd Subfamily PTPDC1 481-583 3.7e-08 28.0 In-house 76-169 (182) alignment 
Range on Protein: 481-583
Range on HMM: 76-169/182.0
ERAVRRMVRQFNFTvWPDKGVPQYATAvLAFRrKVRALNPrDAGPVIVHCSAGVGRTGAYIVIDAMLeQAkinrTVDIRNYLIALRKDRPHMVQTKEQYS
|  ... .  .||. |.| ||.   .. |    || |    . | | ||| || ||||  |    .  .      ..  . .  .|. ||. .||.||  
ealmeqgiyvynfg.wkDygvasleri.Ldiv.kvvafal.qegkvavhChaGlGrtGvliacylvy.ak....rltaekaiklvrskrpksiqtreqve

FIH
...
lvk
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 356-440 1.1e-07 25.6 In-house 33-115 (332) alignment 
Range on Protein: 356-440
Range on HMM: 33-115/332.0
ANKKKNRYGNIVTYDHSRVVLERVNGDedSDYINASFIHGFDGTpRSYIASQGPPPPTFE-GFWRMVWEQNSQSIVMLTNLVELGK
 |   ||   .  .||||| |   .|    |. |||.. |.     .|| .| |     |  ||||| |..   |... .. |  |
nnmdmnriphlycfdhsrvelapqdgk..ddfynaswvdgyskk.sayifaqapfndhteyvfwrmvserkpsmilvfgdidekqk
0038934 (Phosphotyrosine protein) phosphatases II 495-583 8.2e-07 24.4 In-house 86-170 (194) alignment 
Range on Protein: 495-583
Range on HMM: 86-170/194.0
VWPDKG-VPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIViDAMLEQakinRTVDIRNYLIALRKDRPHMVQTKEQYSFIH
 .||.| ||....    ..   . ||    | | ||| ||.||||  ..  ....     .  . .  .  .|  ||..... .... ..
pfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlva.aYLiyr....lgmsaeeAialfrekRpgaipnqdyleall
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 802-882 1.1e-06 22.3 In-house 249-343 (349) alignment 
Range on Protein: 802-882
Range on HMM: 249-343/349.0
DLLDDVQTS--QQQCGNAPVLVQCSNGVGRSGTFCVISSVIERLK--TEQ--VID--------VFQVIKRIRVNRPGAVESLTQYVFCYQIIQKY
||.||  .    ..   ...|| || | ||.|... . .... |.  ...   |.        .. ..  .|  |   |. |.|....|. . ||
dliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLky
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 402-478 2.6e-06 21.0 In-house 237-312 (440) alignment 
Range on Protein: 402-478
Range on HMM: 237-312/440.0
SYIASQGPPPPTFEGFWRMVWEQNSQSIVMLTNLVElgkTKCHKYWPEKTE--TYGGVTVTLHQTEVFADYVIRTFILF
..||.| |   |   |||.| . .  .|.|| .| .     |  ||| .|   |.|  ||  . .| .    .||. | 
afiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelk
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 437-583 4e-06 20.5 In-house 144-295 (332) alignment 
Range on Protein: 437-583
Range on HMM: 144-295/332.0
ELGKTKCHKYWPEKTETYGGVTVTLHQTEVFADYVIRTFILFREERAVRRMVRQFNFTVWPDK-GVPQYATAVLAFRR--KVRALN--PRDAGPVIVHCS
||    |.|.||||.      ..... .. ...  ..|| |   |.   .    . |  | |   .|.|   . |  .   .|. .      ||... |.
elkakicrkfwpekrskkdfpalsiqasddhsethmktfnltvtekkqdhqtvlmhfyewadasklpeymldmrasiklqyirsskktgvcigpimlvca

AGVGRTGAYIVIDAMLEQAKINRTVDIRNYLIALRKDRPHMVQTKEQYSFIH
.|| .   .  || .. .   .. | ... . |.. .|   ..|   ||   
tgvekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpystac
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 369-500 5.5e-06 20.7 In-house 5-125 (130) alignment 
Range on Protein: 369-500
Range on HMM: 5-125/130.0
YDHSRVVlervngdeDSDYINASFIhGFDGTPRSYIASQGPPPPTFEGFWRMVWEQNSQSIVMLTNLVElgktkCHKYWPEKT--ETY-GGVTVTLHQTE
.. ||.         . .||||||. |  |  . |. .| |   |   ||.|. |.    .|.|  . |       .|||.    | |   ..||| . .
fevsrlq........gntyinasfv.Gllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsvee.....edeywpdsePlewyeediivtltdrd

VFaDYVIRTFIlFREERAV--RRMVRQFNFTVWPDKG
 | ...  ...   |.  .   . .  |. . ||  |
ef.knikasnl.eiesdlneshqaltmfqisnwpsdg
0038934 (Phosphotyrosine protein) phosphatases II 779-878 5.6e-06 21.6 In-house 78-172 (194) alignment 
Range on Protein: 779-878
Range on HMM: 78-172/194.0
EVRHLHHVSWPDKCIPEVACSVLDLLDDVQTSQQQCGNAPVLVQCSNGVGRSGTFCVIsSVIERLKTeqviDVFQVIKRIRVNRPGAVESLTQYVFCYQI
   . ..  .||.. .     .|. || |..  ... .  |.| |  |.||.||...    |.||.     .. . |...|  ||||...  ..   .. 
agieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa.YLiyrlgm....saeeAialfrekRpgaipnqdyleallkr
subfamily_eak_pd Subfamily eak 815-883 8.4e-06 19.4 In-house 236-305 (332) alignment 
Range on Protein: 815-883
Range on HMM: 236-305/332.0
GNAPVlVQCSNGVGRSGTFCVISSVIERL--KTEQVIDVFQVIKRIRVNRPGAVESLTQYVFCYQIIQKYL
 .||. .|...|  |.|.| ||  .|. .  | . .  | ..| ...  |  .|    |. | |.|. .||
sfapi.iqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyl