Gene NvecPTP-sf2-6 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily NvecPTP-sf2
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP049_AA protein Get Run
NvecP049_AA_309-584 phosphatase_domain Get Run
NvecP049_AA_596-877 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 304-766 1.2e-237 785.1 In-house 2-463 (564) alignment 
Range on Protein: 304-766
Range on HMM: 2-463/564.0
SKPIPIALFPEYVAKMQANGGIRLENEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPL
|||||.| ..|.|||..||.....|.||||...||||.||||.|||||.|||||||||||||||||..|.|||.|||||||||.||. .....||.||||
skpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPl

PPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK-IETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVL
....| ||||||||||..|||||.|.| ||.|||||||.|  ||||..||||...| .||||||||.|.|.|.| ||.||||||| |||.|||..||..|
aetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslL

AFRRKVRALNPRDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSETYNQAMQKL
...|||||||..||||..|||||||.||||.||||||||..|...||||..|..||||.|..||||.|||.|||.|.||||.|||||..||...|..|||
dlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkL

ASVNRKFQMTGYALEFQRLNsvTSREIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFW
|.|.....|||..||||||.  |..||..||..|...|.|..|||||.|.||.||||.|....|.||||||||..|.|.|...||||||.|| .||||||
aeveedtemtgleleFqrLa..takeieleefavatkpknkkknrfsnilalescrvvlsairakeesdyinasyleayrekrafiatqaplkntvedfw

RMVTDYDIGTIVMLNNLHE-LDQEYPQYWPDHGATKYGHIGVSVLSKQEKGDVICTKLKVTRKKV
|||.......||||..|.| |..|. .|..|..|||||.|...||.|.||.|....| ||..|. 
rmvweeevkiivmltkleekleeesseyysdleatkyGeitikvlkkkeksdilfrkkkvevkek
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 586-883 2.3e-145 478.4 In-house 1-297 (298) alignment 
Range on Protein: 586-883
Range on HMM: 1-297/298.0
GNTEIQSETYNQAMQKLASVNRKFQMTGYALEFQRLNSVTSrEIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRN
|||||..|....|.||||.|..|...|||||||||||||.| ||..|||.|...|.| .|||..|||||.|.||.|..|.||||||||||.||||..|||
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvss.eieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn

AFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ-EYPQYWPDHGATKYGHIGVSVLSKQEKGDVICTKLKVTRKKVRrKTQEVCHLHHVSWPDK
||||||.|| |||||||||||..||||||||.||.|||. .|..||||.|...||.| ||.|||.|..|.|..||||..||.. |..||..||..|||||
afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdk

CIPELACSVLDLLDEAQTSQQQCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFDSFSDYA
..|| |.||||||.. ..||||.||.||.||||.||||||||.||.|||||.|.|||.|||||.|..|.. ||||.. .|| |.|.......|||.|..
gvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 301-591 6.8e-137 450.6 In-house 3-298 (298) alignment 
Range on Protein: 301-591
Range on HMM: 3-298/298.0
DDLSKPIPIALFPEYVAKMQANGGIRLENEYKKFNNGQQ----FPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPrSF
....... .|......|...... .....|....|....    . .|.||||.||.|||||.|.|.|.||||||....||.||||||||.|.|.|.. .|
teieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn.af

IASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPD-KIETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVP
||.|.||....|.|||||.|.....|||||||.||.|||.|||||| . |||| .||.|...| |||...|....||.|....|.|||.|||.|||||||
iatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvp

QYATAVLAFRRKVRAlNPRDAG--PVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQ
..||.||...||||| ....||  ||||.|||||.|.||.|.||..||..||...||.......|||.||..|||.|||.||..||||||...|.||.
enatsvldllrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndeie
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 344-592 8.9e-124 406.6 In-house 3-245 (250) alignment 
Range on Protein: 344-592
Range on HMM: 3-245/250.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTkCHKYWP-D
 |.||.||.|||||.|.|.|.||||||...||..||||||||.||||.. ..|||.||||....|.|||||.|..|..|||||||.| .|| .|.||| .
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve

KIETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR-DAGPVIVHCSAGVERTGTYIVIDAMLE
| |.||.|||.|...|.||||..|...|||||....|.|||.||.||||||||..|||||....||.| ... ...||||.||||| |.|..|.|||.||
kaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavle

QAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCgnteiqS
..||...||.......|||||||.|...|||.|.....|.||..      .
rlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds......v
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 634-884 3.9e-122 401.3 In-house 1-250 (250) alignment 
Range on Protein: 634-884
Range on HMM: 1-250/250.0
KSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQEYPQYWPDH
|||...|||..|||..|||||.|.||.|..|..|.|||||||.|||....|.||||||.|| .|.|||||||.....||||||.||.| ...|.||||  
ksvakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPve

GATKYGHIGVSVLSKQEKGDVICTKLKVTRKKvRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQCGNAPVLVQCSNGVGRSGTFCAISSVL
.|.|||.. ||.|||.|..|.. .|||....| . . . | .||.|.||||..|| | .||.||.. |.||||.|||||.||||.||||||.|.||..||
kaekyGdvtvsllskeefadytkrklklskak.kaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavl

ERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFDSFSDYAN
||||.|.|.|||.|||..| . |.|||| .|| |.|.||.|. ||..|||.
erlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedyar
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 307-621 1.4e-113 374.2 In-house 2-318 (318) alignment 
Range on Protein: 307-621
Range on HMM: 2-318/318.0
IPIALFPEYVAKMQANGGIRLENEYKKF-NNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPP
|..  . . |......| . |..||...  . ... .  . .|.||.|||||||.||||.|| |. ..|.|.||||||..| ||    ...||.|.||| 
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyr.rkkayiaaqaPlpe

AFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKI-ETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAF
..| ||||||||||. |||||...| ||.|.|.|||.|  ..|| ..|.|...  ..|| .|.| ... . . ||.|||.|.| |||.|||. .. .|..
tieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldl

RRKVRALN-PRDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSETYNQAMQKLA
 |.|.. . . .|||..||||||| |||..|..|..||..|.  .||. ..   ||. |. ||||..|| ||. ..||||..|.||....  .. ...| 
vrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelr

SVNRKFQMTGYALEFQRL
 .. .  .|   .|||||
eqdpesgttemdaefqrl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 305-619 2.4e-106 350.4 In-house 3-319 (319) alignment 
Range on Protein: 305-619
Range on HMM: 3-319/319.0
KPIPIALFPEYVAKMQANGGIRLENEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLP
..|... . |.. .....|   ||.|.|........ .. | |. ||.|||| ||.|||..||||  ..| |.||||||||| ||.   . ||| |.|| 
teievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqer.ekfiatqaPle

PAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKI-ETYGGVTVTLHQSEIFADYEIRTFILSKAKRSG-SRMVRQFHFTVWPDKGVPQYATAVL
 ..| |||||||..|  .||||.||| .| |..||||..  |.|| ..||| . |  .||.|| . | |..    .|.| .|..| |||..||..||..|
ntiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatsll

AFRRKVRALNPR-DAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSETYNQAMQK
.. ...|    . ..||..||||||| ||||.||.|||||. |.  ..|. ..   ||  |. |||..|||.||. |.|||...|.|||. .  .. ...
dllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkq

LASVNRKFQMTGYALEFQ
||. . .  .|| . |||
laekvadtgetglerefq
subfamily_PTPRG_pd Subfamily PTPRG 307-597 7.9e-102 336.3 In-house 1-301 (563) alignment 
Range on Protein: 307-597
Range on HMM: 1-301/563.0
IPIALFPEYVAKMQANGGIRLENEYK---KFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDS-DYINASFIHGYDgTPRSFIASQGP
.|.  | ..||.. |.| |....|..   .  . .... |...|| ||.|||| ||||||.||| |. . | ... |||||..|.||    . |||.|||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyq.kskafiatqgp

LPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP-DKIETYGGVTVTLHQSEIFADYEIRTFILSK--AK----RSGSRMVRQFHFTVWPDKGVP
|.  |. ||||.||||.. |||.||||| |. ||. ||| |. |||| ..||| ..|..| | .||... .   |    .   ..|||.|.| |||.|||
lkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvP

QYATAVLAFRRKVRALNPRDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSETY
.... || | .|  | |...|||..||||||| |||||||.|..|.| ..  .|.. . |  .|  |...|||.||| |.| |.|||.. ..||...|  
ehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqv

NQ
..
ee
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 343-581 2.7e-101 332.7 In-house 1-239 (239) alignment 
Range on Protein: 343-581
Range on HMM: 1-239/239.0
EAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPD
|||.|  || ||||||||.|||||||||... |  |||||||... |||.|...||.|| . ..   ||||.|..    ||||| |.|  | |||.||||
eaakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd

KIETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVERTGTYIVIDAMLEQ
    |  . |||...|.|||| ||||..|.  ..  | | |.|||||||||||||||||| .|||.   .   | | ..|||||| |||...|||||| |
stskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq

AKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
||| .|||| ||. |.|.|||||||| ||| ||| ||||
akkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 344-582 2.9e-101 332.6 In-house 1-239 (239) alignment 
Range on Protein: 344-582
Range on HMM: 1-239/239.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK
||.|  || ||||||||.|||||||||... |  |||||||... |||.|...||.|| . ..   ||||.|..    ||||| |.|  | |||.|||| 
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

IETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVERTGTYIVIDAMLEQA
   |  . |||...|.|||| ||||..|.  ..  | | |.|||||||||||||||||| .|||.   .   | | ..|||||| |||...|||||| ||
tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

KKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
|| .|||| ||. |.|.|||||||| ||| ||| |||||
kkqktvdifnyvkairedrphmvqtseqyvfihlavlea
subfamily_PTPRB_pd Subfamily PTPRB 304-585 2.7e-100 330.2 In-house 4-287 (293) alignment 
Range on Protein: 304-585
Range on HMM: 4-287/293.0
SKPIPIALFPEYVAKMQANGGIRLENEYKKFNN-GQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGP
|||| .  | |.|.||.|.  .|. .||..... |..   .||....|..|||| ||..|||||| |. ......||||||..|.||  .|| |||.|||
skpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgyn.sprefiatqGP

LPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK--IETYGGVTVTLHQSEIFADYEIRTFILSKakRSGSRMVRQFHFTVWPDKGVPQYATA
|| ... |||||||..|. |||||.||| ||.||..|||..    .|| ..||| ..|   |. ||.. ..|  .. .| |||.||| ||| |||. ...
lpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektkt

VLAFRRKVRALN--PRDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTC
.|.| |.||       ...|..||||||| ||||.| .| .|.. ... .|||   ...||..| ..|||..|| |||..||. |. 
lldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk
0040438 (Phosphotyrosine protein) phosphatases II 312-605 1.3e-98 325.5 In-house 5-298 (317) alignment 
Range on Protein: 312-605
Range on HMM: 5-298/317.0
FPEYVAKMQANGGIRLENEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRsFIASQGPLPPAFEGFW
..... .. ...  .|..|.... . .  ... |..|.||.|||| .|. ||||||.|  ..||.||||||||...|.. ... ||| |||||  .| ||
lllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrk.fIatqgPlpntvedFw

RMVWEQNSQSIVMLTNLVELGKTKCHKYWP-DKIETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRA
||||||....|||||.|.|||. ||..||| ..  |||..|||| . |  |....||. ... . | ||.|..||.| ||| |||.. . .|.| ..||.
rmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavre

LNPRDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSETYNQAMQKLASV
 .... |||.||||||| ||||.|... |||| .| ..||. . .  ||. ||..||| ||| |.. |.|| |....| .    .  ...||  .
aledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllkllip
0051299 (Phosphotyrosine protein) phosphatases II 305-583 2e-98 324.6 In-house 3-286 (288) alignment 
Range on Protein: 305-583
Range on HMM: 3-286/288.0
KPIPIALFPEYVAKMQANGGIRLENEYKKFNNGQ-QFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRsFIASQGPL
..|..  . ..| |..|||  .|..|.... . . .... ||..|.|..|||| .|..||||||.|  ..|.|.|||||||.|.||. . . ||| ||||
teisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk.fIatqgPl

PPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP-DKIETYGGVTVTLHQSEIFADYEIRTFILSKA----KRSGSRMVRQFHFTVWPDKGVPQYA
|  .| |||||||||.. |||||.|||||..||..||| .. .||| .||||   |...|| .||.....     . . ||.|..||.| ||| |||...
pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

TAVLAFRRKVRALNPRDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
...|.| |.||  .. . |||.||||||| ||||.|..| .||| .| ..||. ...  ||. ||.|||| ||| |.. |.||.|
ellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0050432 (Phosphotyrosine protein) phosphatases II 307-587 5.6e-98 323.3 In-house 26-303 (308) alignment 
Range on Protein: 307-587
Range on HMM: 26-303/308.0
IPIALFPEYVAKmqANGGIRLENEYKKFNNGQQ-FPWEAARKPANKNKNRYANIVAYDHSRVVLervngDEDSDYINASFIHGYD-GTPRSFIASQGPLP
...  . ... |  |..  .|| |...... .  .....|..|.||.|||| .|..||||||.|     ||.|||||||...||. . || ||| |||||
lsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlp

PAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK----IETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATA
  .| |||||||||.. |||||.||| |. ||..|||..    ...||..||||   |...|| .||..|.. . . ||.|..||.| ||| |||.....
ntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspei

VLAFRRKVRALNprDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGN
.|.| ..||  .  . ||..||||||| ||||.|..| .||| .| ..||. ...  ||. ||.||||.||| |.. |.|| | .  
lldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
subfamily_PTPRA_pd Subfamily PTPRA 305-617 3.2e-97 320.4 In-house 12-329 (330) alignment 
Range on Protein: 305-617
Range on HMM: 12-329/330.0
KPIPIALFPEYVAKMQANGGIRLENEYKKFNN-GQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPL
 |.|.  . | . . .|.   .. .|.. .     |   |.| |  ||.|||. ||. ||.|||.|  ..| |.|||||||||.||     .|||.|||.
fplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykek.dkfiaaqGPk

PPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK-IETYGGVTVTLHQSEIFADYEIRTFILS----KAKRSGSRMVRQFHFTVWPDKGVPQYA
  . | ||||.|||.|..|||||.| |  ..||..||||. . ||| ..|.......  || .| |..     ....  ||.||||||| ||| |||  .
eetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfep

TAVLAFRRKVRALNPRDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSETYNQA
  .| . .||..||.. |||..||||||| ||||.||.||.||. |  | ||. . .  ||. ||.||||.||| ||. ..||    |.||..  . .. 
iGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekh

MQKLASVNRKFQMTGYALE
.||| .   ... .|   |
lqklynkitgtdkigleee
subfamily_PTPRK_pd Subfamily PTPRK 316-600 4.4e-97 319.7 In-house 13-294 (314) alignment 
Range on Protein: 316-600
Range on HMM: 13-294/314.0
VAKMQANGGIRLENEYKKFNNGqqfpWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVW
.|..... |  . .||. . .|    |.||.|  |..|||. .|.|||.|||.|  ..|| .||||||..| .|   |. ||. ||||.   . |||.|.
iallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsyk.rpaafivtqgPlqetvkdfWrlvy

EQNSQSIVMLTNLVELGKTKCHKYWPDKIETYGGVTVTLHQSEIFADYEIRTFILSKA--KRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNP
..|. ||||||.||| |. || ||||.. |.|| . |.| ..|. |.. .|.| ..|.  . .. |.||||.|. ||| .||..||..|.. |.| . ..
dencasivmltelvevgrvkClkyWPedtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqe

RDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSETYNQAMQ
 .||...||||||  ||||.|.|| .|. ... ..||. |   .||. .. ||.|.||| ||. ..|||  ||.| |    .. .  
eeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalyl
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 305-603 9.5e-96 315.4 In-house 4-299 (315) alignment 
Range on Protein: 305-603
Range on HMM: 4-299/315.0
KPIPIALFPEYVAKMQANGGIRLENEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLP
.|||.  .  |||. .|.    ....|.    || .| . |.|  ||.|||| ||.|||.||| |  .. |..|||.||.|| ||.  .| .||.|||..
qpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGyn.kkrryiaaqgpnv

PAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKIETYGGVTVTLHQSEIFADYEIRTFilSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAF
 . . |||.|.|..   |||||||||  | |. ||||||  .|| .|||. . |.. .| .||.  |   ..  | | |.|.| ||| |||.|..... .
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviyGkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnl

RRKVRALNPRDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSETYNQAMQKLA
 |.|.  .  ..|...||||||| ||||.| .||.|.||.  . .|. |..  .|. | .|||. ||| ||..|.||.. ||.| |  . | |  . | 
irtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqrydsll
0046845 (Phosphotyrosine protein) phosphatases II 327-588 9.8e-94 309.2 In-house 2-279 (284) alignment 
Range on Protein: 327-588
Range on HMM: 2-279/284.0
LENEYKKFNNGQQF---PWEAARKPANKNKNRYANIVAYDHSRVVLERVNGD-EDSDYINASFIHGYD----GTPRSFIASQGPLPPAFEGFWRMVWEQN
|| |... .. . .   ....|..|.|..|||| .|..||||||.| ...|| |||||||||...|||     ... ||| |||||  .| |||||||||
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

SQSIVMLTNLVELGKTKCHKYWPDK--IETYGGVTVTLHQSEIFADYEIRTFILSKAK-RSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNP--
.. |||||.||| |..||..|||..    |||..||||   |.. || .||. |.. .  . ||.|..||.| ||| |||.... .|.| |.|| |..  
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

RDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSR---TVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNT
 . ||..||||||| ||||.|..| .||| .| .   .||. ...  ||. ||.|||| ||| |.. |.||.| ...|
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt
0043336 (Phosphotyrosine protein) phosphatases II 307-581 1.4e-92 305.4 In-house 2-275 (278) alignment 
Range on Protein: 307-581
Range on HMM: 2-275/278.0
IPIALFPEYVAKMQANGGIRLENEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRsFIASQGPLPPA
|..  ........ .|.  .|..|...... . .... |..|.||.|||| .|..||||||.|. ..||.||||||||.. ||. ... |||.|||||  
isvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprk.fiatqgPlpet

FEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKIETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRR
.| |||||||.....|||||.|||||..||..|||.. .|||..||||   | ..|| .||. ... . . ||.|...|.. ||| |||   . .| | .
vedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflk

KVRALNPRDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
.||  .. . |||.||||||| ||||.|... .|||..| ..||. . .  ||. ||..||| .|| |.. |.||
avrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
0039614 (Phosphotyrosine protein) phosphatases II 306-587 2.5e-92 304.8 In-house 13-293 (297) alignment 
Range on Protein: 306-587
Range on HMM: 13-293/297.0
PIPIALFPEYVAKMQANGGIRLENEYKKFNNGQQfPWEAARKPANKNKNRYANIVAYDHSRVVLERVNG-DEDSDYINASFIHGYDGTPRSFIASQGPLP
|||.  .. .. ...||.  .|..|...  . .  ... |..|.||.|||| .|..||||||.|  ..| |.||||||||.. ||| ..| |||.|||||
piplsvldlllllekansktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlp

PAFEGFWRMVWEQNSQSIVMLTNLVELGKtKCHKYWPDKIETYGGVTVTLHQSEIFADYEIRTFILSKakRSGSRMVRQFHFTVWPDKGVPQYATAVLAF
  .| ||||||||....|||||.|||||. ||..|||.. .|||..|||| . |  ..| .||. ...   . ||.|..|..| ||| |||.... .| |
etvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeeggtygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslelllef

RRKVRALNPR--DAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGN
 ..||  . .  . |||.||||||| ||||.|... |||| .| ..||. . .  ||. ||..||| .|| |.. |.|| | ...
lelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
0036941 (Phosphotyrosine protein) phosphatases II 327-590 1.1e-91 302.5 In-house 15-284 (297) alignment 
Range on Protein: 327-590
Range on HMM: 15-284/297.0
LENEYKKFNNGQ-QFPWEAARKPANKNKNRYANIVAYDHSRVVLervnGDEDSDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQNSQSIVML
|. |.... . . ......|..|.|..|||| .|..|||.||.|    .||.|||||||.. ||| . . ||| |||||  .| |||||||||...||||
llkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrk.fIatqgPlpntvedFWrmvweqnvtvIvml

TNLVELGKTKCHKYWP---DKIETYGGVTVTLHQSEI--FADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR--DAGP
|.|||||. ||..|||   ..  |||..||||   |.  ..|| .||. ... . . ||.|..||.| ||| |||.... .|.| ..||  ..   . ||
telvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggp

VIVHCSAGVERTGTYIVIDAMLEQAK---KSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEI
|.||||||| |.||.|..| ||.| .   | ..||| ...  ||. ||..||| ||| |.. |.|| | ...| .
vlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltke
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 305-603 2.4e-90 297.8 In-house 2-303 (305) alignment 
Range on Protein: 305-603
Range on HMM: 2-303/305.0
KPIPIALFPEYVAKMQANGGIRLENEYKKFNNGqQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLP
|.| .. . .|. .....    ||..||.. .  . . .  .| |||.|||...|. .|..|. |   . ..||||||||...||..   ..|..||||.
kiialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrk.kkyivaqgPlk

PAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKIET---YGGVTVTLHQSEIFADYEIRTFILSK-AKRSGSRMVRQFHFTVWPDKGVPQYATA
   . |||...|   ..|||||.||| || ||..|||...     .| ..|.|.... ..|| .| . .|.  . . || | |...| |||.||||.||.
ntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfats

VLAFRRKVRALNPRDAG-PVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSETYNQAM
.| . ..|.    .| | |..||||||| |||..|..| .||..||  .||. ..| .||. |. ||||..|| |.| |. | .|||.|.|  . .. ..
llslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarv

QKLA
.|| 
nklk
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 316-584 5.5e-90 296.3 In-house 6-277 (281) alignment 
Range on Protein: 316-584
Range on HMM: 6-277/281.0
VAKMQANGGIRLENEYKKFNN-GQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGtPRSFIASQGPLPPAFEGFWRMV
......|    . .||.|... |.. . .|.....|..|||| ||||||..||.... . ....|||||.|. ||.| .. .||.|||.| ... ||.||
lkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykg.ekeyiatqgPvPaslvafWqmv

WEQNSQSIVMLTNLVELGKTKCHKYWPDKI--ETYGGVTVTLHQSEIFADYEIRTFILsKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKV-RAL
|||. . |||.|. .| || |||.||||.    .|| |||. ...|  | |  |.| | ... . .| |.|...| |||.|||. ....| ||..| .. 
weqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlklt

NPRDAGPVIVHCSAGVERTGTYIVIDAMLEQAK-KSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALT
...   |...|||||| |||||| .| ...... . ...|... .  |||.|  ||||  ||.|.. |||.|| 
ekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
0047943 (Phosphotyrosine protein) phosphatases II 320-583 8.2e-90 296.2 In-house 7-272 (273) alignment 
Range on Protein: 320-583
Range on HMM: 7-272/273.0
QANGGIRLENEYKKFNNGQ-QFPWEAARKPANKNKNRYANIVAYDHSRVVLervnGDEDSDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQN
...|  .|. |.... . . ......|..|.||.|||| .|..||||||.|    ||..|||||||.. ||. ... ||| |||||  .| |||||||||
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrk.fiatqgPlpntvedfwrmvweqn

SQSIVMLTNLVELGKTKCHKYWPDK----IETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR
.. |||||.|||||. ||..|||..     .||| .||||   |...|| .||..|.. . . ||.|..||.| ||| |||.. . .| | ..||  .  
vrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalea

--DAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
  . |||.||||||| ||||.|..| .|.| .| ..||. ...  ||. ||.|||| ||| |.. |.|| |
lpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 349-581 1.6e-89 294.2 In-house 2-237 (237) alignment 
Range on Protein: 349-581
Range on HMM: 2-237/237.0
ANKNKNRYANIVAYDHSRVVLERVNGDedSDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPD--KIET
 || ||||.||||||||||||.   ..  ||||||....|.||||...||.|||| .. . ||.|||...   ||||| |.|  . |||||||.  . ..
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGGVTVTLHQSEIFADYEIRTFILSKA-KRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR--DAGPVIVHCSAGVERTGTYIVIDAMLEQA
|| .||.|.. | |.|| .|...|||  .  . |.. |..||.|||.||||...|.| ||...   .|   ..|| |.|||||| ||| ..|||||| ||
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

KKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
|. . ||| ||. .. .|||...|||.|| ||| ..||
kekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
0045450 (Phosphotyrosine protein) phosphatases II 303-583 4.5e-89 294.5 In-house 5-304 (307) alignment 
Range on Protein: 303-583
Range on HMM: 5-304/307.0
LSKPIPIALFPEYVAKMQANGGIRLENEYKKFNNGQQF---PWEAARKPANKNKNRYANIVAYDHSRVVLERVNGD-EDSDYINASFI--------HGYD
||..|..  .  .|.......  .|. |..|... . |   ....|..|.||.|||| .|..|||.||.|  ..|. |||||||||..        .|||
lslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgyd

GtPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK--IETYGGVTVTLHQSEIFADYEIRTFILSKA-KRSGSRMVRQFHFT
  .| ||| |||||  .| ||||.|||... |||||.|||||. ||..||||.    ||| .||||   |. ..| .||. ..   . . ||.|..||.|
l.krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhyt

VWPDKGVPQYATAVLAFRRKVRALNPR--DAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRT---VDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
 ||| |||..   .|.| ..||. . .  . |||.||||||| ||||.|... ||.| .|  |   ||... .  ||. ||..||. ||| |.. |.|| 
gwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel

L
|
l
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 314-582 9.5e-88 289.0 In-house 10-278 (288) alignment 
Range on Protein: 314-582
Range on HMM: 10-278/288.0
EYVAKMQANGGIRLENEYKKF-NNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWR
..|||..|..   ...||..  . ...   .|.|.. |..|||| ||..||. || |. ..  ...||||||.|.|.... . .||.||||. . . ||.
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkk.kkyiatqgPladtvndfWe

MVWEQNSQSIVMLTNLVELGKTKCHKYWPDKIE--TYGGVTVTLHQSEIFADYEIRTFILSkaKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRA
.|.|.... |||||.||| |||||..||||. .   || ||||| .|.   |.  |...|   |. . . . |.....|||.|||. .. .|...|.|  
lvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkv

LNPRDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
 |. |.||.|||||||| ||||.|..||.... ... ..|. . .  ||| |. .|||..|| ||....|. 
anqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsl
subfamily_Ptp69D_pd Subfamily Ptp69D 310-603 1.8e-85 281.8 In-house 7-306 (307) alignment 
Range on Protein: 310-603
Range on HMM: 7-306/307.0
ALFPEYVAKMQANGGIRLENEYKKFN-NGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLPPAFE
   .| . . . .    |..||.| . .  .   ... |  |. |||| .|.|.|. ||.|...||.|||||||||||.||. . ..|||.|.|.    .
ddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykek.kkfiaaqdPveatig

GFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP-DKIETYGGVTVTLHQSEIFADYEIRTFILSKAKRSG-----SRMVRQFHFTVWPDKGVPQYATAVL
 ||||..||... ||||.|| |  . ||.|||| ...  || . |.| ..|   || ||.. .|| | ..     || | |.|.| |.|  ||. |...|
DfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargll

AFRRKVRALNPRDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSETYNQAMQKL
 . ..|| |.  . .|..|||||||.|.|... .| .|.| |.  .||| .    ||..|. .||  |||.|.. |.|.  . |.|... .....|...|
klieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledaierl

A
.
c
DSPc_SM00195 328-583 1.9e-85 281.7 In-house 3-262 (263) alignment 
Range on Protein: 328-583
Range on HMM: 3-262/263.0
ENEYKKFNNGQ-QFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYdGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLT
..|..| .. . . . . |.|..||.|||| ||. |||.|| |.. ...|.||||||..| |.   ....|| |||||  .| |||||||.... |||||
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NLVELGKTKCHKYWPDKI---ETYGGVTVTLHQSEIFA-DYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVH
. .| ||.||..|||...   ||.| ..|.| . |.   ....||. |.| ... .| |.|.... |||.|||. .. ||.. |.|.  . .  ||..||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
|||||.||||...|| .|.. ..  .||| . . .||| ||.||||.|||.||. |.||..
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 328-583 1.9e-85 281.7 In-house 3-262 (263) alignment 
Range on Protein: 328-583
Range on HMM: 3-262/263.0
ENEYKKFNNGQ-QFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYdGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLT
..|..| .. . . . . |.|..||.|||| ||. |||.|| |.. ...|.||||||..| |.   ....|| |||||  .| |||||||.... |||||
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NLVELGKTKCHKYWPDKI---ETYGGVTVTLHQSEIFA-DYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVH
. .| ||.||..|||...   ||.| ..|.| . |.   ....||. |.| ... .| |.|.... |||.|||. .. ||.. |.|.  . .  ||..||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
|||||.||||...|| .|.. ..  .||| . . .||| ||.||||.|||.||. |.||..
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0050432 (Phosphotyrosine protein) phosphatases II 578-882 3.3e-83 274.9 In-house 7-305 (308) alignment 
Range on Protein: 578-882
Range on HMM: 7-305/308.0
AVLEALTCGNTEIQSETYNQAMQKLAS-VNRKFQMTGYALEFQRLNSVTSreipAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLhnehaDEESDYINAV
|.||.|....|.|. ..... ...|.  ..........  ||..|.||.      .| ||.. |.| .|||..||... ..|| |     ||.|||||| 
allelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkp....lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAs

FLHAH--RGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELD-QEYPQYWPDH---GATKYGHIGVSVLSKQEKGDVICTKLKVTRKKVRrKT
. . .  . ...|||||.|| .||||||||| .... .||||..|.| . . ..||||.    | ..||.. | .|| ....|.....|..| ..   ..
yvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg.es

QEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQqqcGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQ
 .| |.|. .||| ..|. . ..||.|.....|.   .. |..| ||.||||.|||.|.  .||.|..|. .|||...|..|   ||.|..| ||||.|.
rtvthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyr

IIQKYFDSFSDY
....|. ..  .
alleylklkltk
0040439 (Phosphotyrosine protein) phosphatases II 341-583 1.7e-82 272.1 In-house 2-246 (249) alignment 
Range on Protein: 341-583
Range on HMM: 2-246/249.0
PWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYW
... |..|.||.|||| .|..||||||.|. ..| ..|||||||.|.||. ..| ||| ||||| ..| ||||.||.....|||||.|||||. ||..||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr.fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqyw

P-DKIETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR--DAGPVIVHCSAGVERTGTYIVID
| ..  .||..|||| . |...|| .||. |.. . . ||.|.....| ||| |||..   .|.| ..||  . .  . |||.||||||| ||||.|...
plggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaay

AMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
 |||| .| ..||. ...  ||. ||..||. ||| |.. |.|| |
lmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 344-602 8.6e-82 270.0 In-house 55-310 (319) alignment 
Range on Protein: 344-602
Range on HMM: 55-310/319.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTnlvelgKTKCHKYWPDK
 |  . ||.|||. ||.|.|...| |||..| | ||||||||. ||   .  .||.||||. . . ||||.||.|. .||.||      | || .||| |
fanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyq.rkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplk

I-ETYGGVTVTLHQSEIFADYEIRTFILSK-AKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAG--PVIVHCSAGVERTGTYIVIDAM
| ....   | ..  |  |.| .| . ||. .|  . | ..||||  |||.|||.|.. .. . .||| |. .  .  ...||||||| |||.|||.|..
ivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvl

LEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSETYNQAMQKL
|.. |. . ||. |..  ||..|...||   || ||.||.||    |....    .   ...|
ldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleel
Y_phosphatase Protein-tyrosine phosphatase 350-581 1.2e-81 269.0 Pfam-A 1-235 (235) alignment 
Range on Protein: 350-581
Range on HMM: 1-235/235.0
NKNKNRYANIVAYDHSRVVLervNGDED-SDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP---DKIE
||.|||| .|..||..|| |   .|.|. ||||||....||. ....|||.||||.  .| ||||||......|||||.|.| |..||..|||   .. .
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

TYGGVTVTLH-QSE-IFADYEIRTFILSKAKRS-GSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVERTGTYIVIDAMLEQ
||| ..|.|  ... . ..| .|.. |.| |..  .|.|.|.|.| |||.|||. ....| . |||.  .  . |||.|||||||.||||....|..|||
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

AKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
... ..||. ...  ||| ||.|||. ||| |.. |.||
leaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 350-581 1.2e-81 269.0 In-house 1-235 (235) alignment 
Range on Protein: 350-581
Range on HMM: 1-235/235.0
NKNKNRYANIVAYDHSRVVLervNGDED-SDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP---DKIE
||.|||| .|..||..|| |   .|.|. ||||||....||. ....|||.||||.  .| ||||||......|||||.|.| |..||..|||   .. .
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

TYGGVTVTLH-QSE-IFADYEIRTFILSKAKRS-GSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVERTGTYIVIDAMLEQ
||| ..|.|  ... . ..| .|.. |.| |..  .|.|.|.|.| |||.|||. ....| . |||.  .  . |||.|||||||.||||....|..|||
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

AKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
... ..||. ...  ||| ||.|||. ||| |.. |.||
leaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 306-627 2.5e-81 268.3 In-house 1-320 (515) alignment 
Range on Protein: 306-627
Range on HMM: 1-320/515.0
PIPIALFPEYVAKMQANggIRLENEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGtPRSFIASQGPLPP
|.|.| || .|.| .      . .|.. .   . .|   |..  | .|||| ||. || .|| || .| . .|||.|||.|...|   ...||||||.. 
plplaqfPafvnknrht..tlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdn.dkayiasqgPnka

AFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK---IETYGGVTVTLHQSEIFADYEIRTFILSKAKRsgSRMVRQFHFTVWPDKGVPQYATAVL
. . |||.|...|   |.|.|.| |  | || ||||||      .| . | |   |  ..  .|.. . | .   || | ||||| |||||||. ....|
svddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssll

AFRRKVRALNPRDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSETYNQAMQKL
 . ..|.| . . . |.|.|||||| ||| .| || .. .||..|.||. |..  .|..||..|||.|||.||. |||| |   || |    . . .| |
klikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdl

ASVNRKFQMTGYALEFQRLNSVTSR
 |       .  . ||| |.|..  
hssgdgrgrskmtkefqtlkslcpd
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 305-605 4.1e-81 267.3 In-house 1-299 (315) alignment 
Range on Protein: 305-605
Range on HMM: 1-299/315.0
KPIPIALFPEYVAKMQANggIRLENEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGtPRSFIASQGPLP
.|||.| || .| | .      . .|.. . . . ..  .||.. | .|||| ||. .|..||.|| .. . ||||||||.|...|   ...|||||||.
qpipvaqfpafvnknrht..alfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdd.dkayiasqgPlk

PAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPD---KIETYGGVTVTLHQSEIFADYEIRTFILSKAKRsgSRMVRQFHFTVWPDKGVPQYATAV
 . . |||||....  .|||.|.. |  | || .||||   .   .| . |.| . |  .|  .| ... |..   || | ||.|| ||||||.. ....
asvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrksee..srtvtqfqftewPdkGvdkqtssl

LAFRRKVRALNPRDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSETYNQAMQK
| . ..|.| | ..  ...||||||| |||  | || ...|.|..|.||. |..  ||..||..|||.|.|.||. |||| |   || |    . . .| 
lklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqd

LASV
| . 
lhts
0051299 (Phosphotyrosine protein) phosphatases II 586-876 1.2e-80 266.3 In-house 1-286 (288) alignment 
Range on Protein: 586-876
Range on HMM: 1-286/288.0
GNTEIQSETYNQAMQKLAsvnrKFQMTGYALEFQRLNSVTSReipaEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRN
|.|||. | . ....||     . ..||.. ||..| |..       . |..  |.||.|||.|||......|| |.... .|.|||||| ... ..  .
gdteisveellklvlkll....angltglleefeellsllpd....ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkr

AFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELD-QEYPQYWPDHGATKYGHIGVSVLSKQEKGDVICTKLKVTRKK---VRRKTQEVCHLHHVSW
.|||||.|| .||||||||| .... .||||..|.||. . ..||||..| ..||.| |  || ....|.....|.||...      ....| |.|. .|
kfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnw

PDKCIPELACSVLDLLDEAQTSQQqCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYF
|| ..|. . ..||.| .......  |. ||.| ||.||||.|||.|.  .||.|..|...||....||.|   ||.|..| ||.|.|...  |.
pdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 346-603 1.5e-80 265.7 In-house 21-275 (284) alignment 
Range on Protein: 346-603
Range on HMM: 21-275/284.0
RKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTnlvelgKTKCHKYWPDKI-
  . ||.|||. .|.|.|...| |||. | | ||||||||| ||   .  .||.||||. . . ||||.||.|. .||.||      | || .||| || 
nldqnkdknrighilafdknvvklerliGeefsdyinasfitGyq.rkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkiv

ETYGGVTVTLHQSEIFADYEIRTFILSK-AKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAG--PVIVHCSAGVERTGTYIVIDAMLE
....   | ..  |  ..| .| . ||. .|  . | .|||||  |||.|||.|.. .... .||| |. .  .  ...||||||| |||.|||.|..|.
ikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlld

QAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSETYNQAMQKLA
. |. . ||. |..  ||..|...||   || ||.||.||    |....    .   ...|.
rmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleels
0042113 (Phosphotyrosine protein) phosphatases II 343-582 2.4e-80 264.7 In-house 2-242 (245) alignment 
Range on Protein: 343-582
Range on HMM: 2-242/245.0
EAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP-
. |..|.||.|||| .|..|||.||.|  ..||.||||||||...||. ||. |||.|||||  .| ||||.||.....|||||...|||. ||..||| 
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpk.fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl

DKIETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNP-RDAGPVIVHCSAGVERTGTYIVIDAML
. . |||..||||   |...|| .||. ... . . ||.|...|.. ||| ||| .   .| | . ||      . |||.||||||| ||||.|... ||
gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylml

EQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
||..| ..|.. . .  ||. ||..||| .|| |.. |.|| 
eqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
subfamily_PTPN12_pd Subfamily PTPN12 326-583 2e-79 261.5 In-house 16-277 (290) alignment 
Range on Protein: 326-583
Range on HMM: 16-277/290.0
RLENEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMVWEQNSQSIVML
.| .. .|. . .... ||..|. |..|||| .|. ||.|||.|.. ...|.||||||.||.| .|.  ..||.||||| . . ||||.||.| . .||.
klkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegk.leyiaaqgPLpktlddfWrmiweknveivvma

TNLVELGKTKCHKYWPDKIE---TYGGVTVTLHQSEIFA-DYEIRTFILSKAkrSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIV
 ..|||||.||..|||.. |   ..| ..|||.. . .  |. |||. . .   . ||.|.|||.| |||.|||. |. .|.. ..|| |. ... |..|
CrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvv

HCSAGVERTGTYIVIDAMLEQ---AKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
|||||| |||| |.|| . |.    | . ..|. . .. |||.|. .|||||||.... ||.| .
hCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_PTPN6_pd Subfamily PTPN6 329-582 2.5e-79 261.5 In-house 30-296 (306) alignment 
Range on Protein: 329-582
Range on HMM: 30-296/306.0
NEYKKF---NNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLErVNGDEDSDYINASFIH-GYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVM
.|....   .. ...  . ..|| ||.|||| ||. .||.||.|.  ..  .||||||..|.    |. .|.||.|| |.   . ||||||..||. |||
eefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivm

LTNLVELGKTKCHKYWPDKIE--TYGGVTVTLHQSEIFADYEIRTFILSK-AKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRA----LNPRDAG
.|. || || || .||||. |  .|| ..||  ...  |||..|.. .||  | . .| |.|.||..|||.|||.   |||.| ..|..    |. ..||
ttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeag

PVIVHCSAGVERTGTYIVIDAMLEQAKKS---RTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
|..||||||. ||||.||||..|.. .|.     .||..    .|. |  .|||..|| |.. |. . 
pivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikky
0045098 (Phosphotyrosine protein) phosphatases II 336-586 2.4e-78 258.6 In-house 19-275 (278) alignment 
Range on Protein: 336-586
Range on HMM: 19-275/278.0
NGQQFPWEAARKPANKNKNRYANIVAYDHSRVVlervngdedsDYINASFIHGYdgtPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTK
 |.   .. | .. |..|||| .|..||||||.          ||||||.|.||   |. ||| |||||  .. ||||.||.....|||||.|||||. |
lgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy...pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrek

CHKYWPDKI-ETYGGVTVTLHQSEIFADYEIRTFILSKA----KRSGSRMVRQFHFTVWPDKGVPQYA--TAVLAFRRKVRALNPR-------------D
|..|||..  .|||..|||| . |.. || .||...       .   || |...|.. ||| ||| .   . .| . . .|. . .             .
caqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssllllds

AGPVIVHCSAGVERTGTYIVIDAMLEQAkkSRTVDIRNYLIALRKDRPH-MVQTKEQYSFIHSAVLEALTCG
 |||.||||||| ||||..... |||.    ..||. ...  ||. ||. .||..||| |.. ..|| | .|
ggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 613-886 9.5e-78 256.4 In-house 21-290 (318) alignment 
Range on Protein: 613-886
Range on HMM: 21-290/318.0
GYALEFQRLNSVtsREIPAEEKSvgEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGT
 .  |..||. .  .| ... ||   || | .|||. .|.| ...|| |.. . .|.|||||| ..  .| ..|.||.| || ||.||||||| . .  .
llseeyerlsrs..eetvtslks..lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsav

IVMLNNLHELDQ-EYPQYWPDHGATKYGHIGVSVLSKQEKGDVICTKLKVTRKKVRrKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQCGNAP
|||| ...|  .    .|||..|...||.. | . .. | .| .  ..||||...  ....|   |. ||||. .|| ..|.|||. .... ||..|. |
ivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteee.esrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagp

VLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFDSFSDYANYS
..| || |||| |.|.|....|||.| |...||||..|..| . .  |    || |.|......  |.  ... |
ivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdas
0046845 (Phosphotyrosine protein) phosphatases II 616-882 1.1e-77 256.6 In-house 4-280 (284) alignment 
Range on Protein: 616-882
Range on HMM: 4-280/284.0
LEFQRLNSVTSREIpaEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHAD-EESDYINAVFLHAH-----RGRNAFIATQHPLLETVEDFWRMVTDYD
 ||..|.|.|   .   . ||.  |.||.|||..||......|| |.... | |.|||||| ... .     . ...|||||.|| .||||||||| ...
eefeellsltvkll..lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

IGTIVMLNNLHELDQ-EYPQYWPDHG-ATKYGHIGVSVLSKQEKGDVICTKLKVTRKKVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQ-
. .||||..|.| ..  ..||||. |   .||.. | .||...|.|.....|..|....  .. .| |.|. |||| ..|. . ..|..|......... 
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

CGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQ---VIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFDSFSDY
 |. |..| ||.||||.|||.|.  .||.|..|.   ..||....||.|   ||.|... ||.|.|.... |. ..  .
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltl
0037934 (Phosphotyrosine protein) phosphatases II 342-581 2.3e-76 251.8 In-house 2-240 (243) alignment 
Range on Protein: 342-581
Range on HMM: 2-240/243.0
WEAARKPANKNKNRYANIVAYDHSRVVLervngdEDSDYINASFIHGYDgtpRsFIASQGPLPPAFEG----FWRMVWEQNSQSIVMLTNLVELGKTKCH
.  |..|.|..|||| .|..||||||.|      |.||||||..| ...   | .||.|||||  .|     ||||.||.....|||||.|||||. ||.
fsiallpenlsknrysdilpydhsrvkl......egsdyinanliyvtp...r.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekca

KYWPDKIeTYGGVTVTLHQSEIFADYEIRTFILSKAK-RSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRAL--------NPRDAGPVIVHCSAGVE
.|||... |||..|||| ..| ..|| .||. |.  .    .|.|...|.. ||| |||.  . .|.| ..||.         .  . |||.||||||| 
qywpgev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvg

RTGTYIVIDAMLEQAkksrTVDIRNYLIALRKDRPH-MVQTKEQYSFIHSAVLE
||||.|... ||..     .||. ...  ||. ||. .||| .|| |.. |.||
RtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 612-880 1.2e-75 249.6 In-house 23-287 (319) alignment 
Range on Protein: 612-880
Range on HMM: 23-287/319.0
TGYALEFQRLNSVTSReipaeEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIG
|. . ||. |.  ..      . .  ....| .|||...|.| . .||.| . .  |.|||||| |. ... |..||||| || .|.||||||| .... 
tllekefkllkeavnd.....tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeess

TIVMLNNLHE-LDQEYPQYWPDHGATKYGHIGVSVLSKQEKGDVICTKLKVTRKKVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQCGNA
..|||..| | |. .. .|||..  ..||.. | .....|. |.|  |||. .|.   .| || | .. .|||. .|| | |.|||| . . |...  . 
ivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsg

PVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFDSFS
|. | ||.|||| |||.... .|||.| |.|.|||....|.|.  .  |. | || |.|... .. ....
PivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 305-595 1.9e-75 248.8 In-house 8-296 (297) alignment 
Range on Protein: 305-595
Range on HMM: 8-296/297.0
KPIPIALFPEYVAKMQANGgiRLENEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGtprSFIASQGPLP
.|||.. |. .| | .       ..|..   . . .|   |.|  | .|.||.||. || ||| |. || | ||||.||||..|.      .|..| | .
rpiplsdfatlvqknrhtd..vfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh...rlittqmPmk

PAFEGFWRMVWEQNSQSIVMLTNLVELGKtKCHKYWPDK-IETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQ--YATAV
 . . ||.||.... . ||||... |  | || .||.|| . |.| |.|.|.  .    .  |.. ..| |    |.|.|..|. |||| |..   |...
atvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassl

LAFRRKVRALNPRDAG-PVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSETY
| .   ||      |  |..|||.||| ||| .. || .. .||.  .||| ...  ||..||..|||||||.|.. |||||| . .|.||.. .
lklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqasyf
subfamily_PTPN9_pd Subfamily PTPN9 312-581 3.7e-75 247.7 In-house 6-288 (297) alignment 
Range on Protein: 312-581
Range on HMM: 6-288/297.0
FPEYVAKMQANGgirLENEYKKFNNGQ-QFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPAFEGF
. .|| ... .|   | .||..  | . .   .|....|| .||||.... ||..||||..|..|| ||||||.|. ||   ...||| ||||. ... |
lvayvkekgkrG...lskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGyk.qkkafiatqGplkktvsdf

WRMVWEQNSQSIVMLTNLVELGKTKCHKYWP---DKIETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRK
|||||||.   ||| | .|| |. || .|||   .. . .| ..|.  . |   ||..|.. ....| . || |  | |. ||| |||. |...| ...|
WrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlek

VRA--------LNPRDA-----GPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
||         | ....      |..||||||. ||||.| .|  |.. ..  |||... .  ||. | ...|| ||| | . ||||
vrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
0040438 (Phosphotyrosine protein) phosphatases II 609-877 5.1e-75 248.0 In-house 15-277 (317) alignment 
Range on Protein: 609-877
Range on HMM: 15-277/317.0
FQMTGYALEFQRLNSVtsreiPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDY
 ..|.   ||..| |.     . .. ||.| |.| .|||..||. . ..|| |...  |..|||||| . . .. ...|||||.|| .||||||||| ..
sdftalleefedllsl.....kldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweq

DIGTIVMLNNLHELD-QEYPQYWPDHGATKYGHIGVSVLSKQEKGDVICTKLKVTRKkVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQqC
....||||..| ||. . . ||||. . ..||.. | .|| .|..... ..|.|. .    .. .| |.|. .||| ..|.   ..||.|........  
gvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavreale.d

GNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFD
.. |||| ||.||||.|||.|.  .||.|..|. .||....|..|   ||||..| || |.|.....|. 
pggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylk
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 314-609 6.6e-75 247.2 In-house 12-314 (325) alignment 
Range on Protein: 314-609
Range on HMM: 12-314/325.0
EYVAKMQANGGIRLENEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRM
|.| | .|.    . .|..   . .    ..| ||.||.|||. |.||.|.||||||  . | .|||||||... . .    |.|.| ||. . . .||.
ehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkk.dvflaaqaPltatindlWrl

V--WEqnsQSIVMLTNLVELGKTKCHKYWPDK---IETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKV
|  |.    |.|...| ..||| .| .|||..     |.||. | |   | ..||  | . . ..|.  .| |.||..  |.| ||... ...... . |
vldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlv

RAL------NPRDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSETYNQAMQKL
 |.      | . ..|..||||||| |||..| . ..|..  .   ||| ...  |||||| ||.| .||..|. |. ||. .|||..   ...  .  |
kavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklssl

ASVNRKF
   |   
qernplt
0039614 (Phosphotyrosine protein) phosphatases II 602-879 9.3e-75 247.1 In-house 22-292 (297) alignment 
Range on Protein: 602-879
Range on HMM: 22-292/297.0
LASVNRKFQMTGYALEFQRLNSVTSreipaEeKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHA-DEESDYINAVFLHAHRG-RNAFIATQHPLLETVE
|  .......|.. |||..| |..      . .|... |.| .|||..||......|| |. |   |..|||||| ..  ..   ..|||||.|| ||||
llllekansktllllefeellslkp.....d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetve

DFWRMVTDYDIGTIVMLNNLHELDQEYPQYWPDHGAtKYGHIGVSVLSKQEKGDVICTKLKVTRkkvRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDE
|||||| .... .||||..| ||.. ..||||. |  .||.. | .|. ....... ..|.||.     .. .| |.....||| ..|... ..|..|..
dFwrmvweqgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtlevtn...ngesrtvthfqytgwpdhgvppslellleflel

AQTSQQQC-GNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFDSF
... .... .. |||| ||.||||.|||.|.  .||.|..|. .||....|..|   ||||..| || |.|.......  .
vrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
0047943 (Phosphotyrosine protein) phosphatases II 605-876 1.2e-74 246.6 In-house 5-272 (273) alignment 
Range on Protein: 605-876
Range on HMM: 5-272/273.0
VNRKFQMTGYALEFQRLNSVTSreipAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLhnehADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRM
.......|....||..| |..       ..||.. |.|..|||..||......|| |     |..|||||| ..  ..  ..|||||.|| .||||||||
lekllgltllleefelllslkp....lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrm

VTDYDIGTIVMLNNLHELDQ-EYPQYWPDHG---ATKYGHIGVSVLSKQEKGDVICTKLKVTRKKVRRkTQEVCHLHHVSWPDKCIPELACSVLDLLDEA
| .... .||||..|.||..  ..||||. |    ..||.. | .|| ..|.|.. ..|..|...    . .|.|.|. .||| ..|.   |.|......
vweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielv

QTSQQQC-GNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYF
.. .... .| ||.| ||.||||.|||.|.  .|..|..|. .||....|..|   ||.|..| ||.|.|... .|.
rkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0036941 (Phosphotyrosine protein) phosphatases II 604-878 1.3e-74 246.5 In-house 5-279 (297) alignment 
Range on Protein: 604-878
Range on HMM: 5-279/297.0
SVNRKFQMTGYALEFQRLnsvtSREIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLhnehADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWR
 ..........  ||..|     . ..  ..||.. |.||.|||..||......|| |     ||.|||||| ..  ..  ..|||||.|| .|||||||
llekllflalllkefeel....lpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWr

MVTDYDIGTIVMLNNLHELDQ-EYPQYWPDH--GATKYGHIGVSVLSKQE--KGDVICTKLKVTRKKVRrKTQEVCHLHHVSWPDKCIPELACSVLDLLD
|| .... .||||..| ||.   ..||||.   .  .||.. | .|| ..  ..|.. ..|.|| ..   .. .| |.|. .||| ..|| . |.||...
mvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgng.esrtvthfhytgwpdhgvpespaslldfie

EAQTSQQQC-GNAPVLVQCSNGVGRSGTFCAISSVLERLK---TEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFDS
.... ...  .. |||| ||.||||||||.|.  .|..|.   .|. .|.....| .|   ||||... ||.|.|....... .
lvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkk
0045450 (Phosphotyrosine protein) phosphatases II 610-876 2.1e-72 239.8 In-house 25-304 (307) alignment 
Range on Protein: 610-876
Range on HMM: 25-304/307.0
QMTGYALEFQRLNSVTSREipAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHAD-EESDYINAVFL--------HAHRGRNAFIATQHPLLETVED
 .||.. ||..|.||| .     | |... |.| .|||..||......|| |.... . |.|||||| .         . ..  ..|||||.|| |||||
fltgllkefekllsvtvfl..lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetved

FWRMVTDYDIGTIVMLNNLHELDQE-YPQYWPDHGAT-KYGHIGVSVLSKQEKGDVICTKLKVTRKKVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLD
||||. ......||||..| ||..| ..||||| | .  ||.. | .||...........|.||...   .. .|.|.|. .||| ..|.   ..||...
FwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfie

EAQTSQQQC-GNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQV---IDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYF
|... .... .. |||| || ||||.|||.|.  .|..|..|..   .|.....|..|   ||||..| || |.|.......
evrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_PTPRA_pd Subfamily PTPRA 621-876 3.4e-72 238.1 In-house 38-295 (330) alignment 
Range on Protein: 621-876
Range on HMM: 38-295/330.0
LNSVTSREIPAEEKSVgEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLH
.|.. . .| |  .   .. .| .|||. .|.  .  ||.| . .  |||||||| |.. .. .. |||.| |. |||||||||. ...  ||||| .|.
fnalPagpiqatlela.skeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelk

ELDQEY-PQYWPDHGATKYGHIGVSVLSKQEKGDVICTKLKVTR---KKVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQCGNaPVLVQC
| ..|   |||||.|.  ||.| |.|  ...  |.   |. |..   .. ..|.. |  .|  ||||  .|  .  .|.|| . .. .|| .. |. | |
erkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhc

SNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYF
| ||||.|||.....||||.|.|...|||...||.| . |  | .  || |.|.....|.
saGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 631-879 3.4e-72 238.2 In-house 35-286 (305) alignment 
Range on Protein: 631-879
Range on HMM: 35-286/305.0
AEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQEY-PQY
 |   ||.. .| .|||...|. |.  |..| ... ...|||||| ...........|..| || .||.||||.. .. . ||||| .| | ...   ||
eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqY

WPDHGAT--KYGHIGVSVLSKQEKGDVICTKLKVTRKKVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQCGNAPVLVQCSNGVGRSGTFC
||.  .   ..|.. | . |...  | |  |||.. ..  .... | ...  .|||. .|. | |.|.|... | .|..  . |.|| ||.||||.|.|.
WpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfi

AISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFDSF
|..  |||||.|.|.|||.|.|..| . ...|..  || |........  ..
avdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 341-581 1.1e-71 236.1 In-house 19-266 (274) alignment 
Range on Protein: 341-581
Range on HMM: 19-266/274.0
PWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDE-DSDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKY
. |  . . ...|||| .|.  ..|||.||. .... ||.|||| .|.|||.. . ..| ||||| . . ||||......| |||||.| |  ..||..|
dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavy

WPDKIET-----YGGVTVTLHQSEIFADYEIRTFILSKAKRsgSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR---DAGPVIVHCSAGVERTG
.||....     ||.| .. ..     ||..|...|....|  .| |  . .| |||. .|. |...| . ..|.  . .    ..||.||||||. |||
fPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtG

TYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
 .| |.  . | ... .||. .    || ||  ||||.||| .|| |. .
cfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 307-587 1.7e-71 235.4 In-house 2-287 (290) alignment 
Range on Protein: 307-587
Range on HMM: 2-287/290.0
IPIALFPEYVAKMQANGGIRLENEYKKFNNGQ-QFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDED--SDYINASFIHGYDGTpRSFIASQGPL
||.  | |.||. .|.|  . .|..|....|. ..  . .  . ||..||.|||| ||  |..| ...|..|   .||||..|.||    ...|| |||.
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykek.kqyiatqgpv

PPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK-IETYGGVTVTLHQSEIFADYEIRTFILSKAKR-SGSRMVRQFHFTVWPDKG-VPQYATA
.     ||...|....  |||||| .| ||.||..||||.  ..|| ....|.. |.. .| .|.. . . .    ...| |...| |...| |....| 
sntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqti

VLAFRRKVRALNPRDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGN
.|.... ..    |  ....||||..| |........  ....|.   .|. . |  .|  .| .|||..|| .|.. ||..|.. .
llvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfe
DSPc_SM00195 617-876 3.4e-71 235.0 In-house 5-262 (263) alignment 
Range on Protein: 617-876
Range on HMM: 5-262/263.0
EFQRLNSVTSREipaeEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVML
||..|.. || .    |.. .|...| .|||...|.  .. || |..|. .|.|||||| ..  .. ....||||.|| .|||||||||.. .. .||||
efekleestspk....etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

NNLHEL-DQEYPQYWPDH--GATKYGHIGVSVLSKQEKG-DVICTKLKVTRKKVrRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQCgNAPV
..  |   ..  .|||.   | ...|.| | . ....|  ..| ..|..| ..  ..|..| .... .|||. .|. . |||.|| ....|...  ..|.
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpi

LVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYF
.|.||.||||.|||..|...|..|..|. .|.|...|..| . ||.|.. .||||.|..| .|.
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 617-876 3.4e-71 235.0 In-house 5-262 (263) alignment 
Range on Protein: 617-876
Range on HMM: 5-262/263.0
EFQRLNSVTSREipaeEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVML
||..|.. || .    |.. .|...| .|||...|.  .. || |..|. .|.|||||| ..  .. ....||||.|| .|||||||||.. .. .||||
efekleestspk....etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

NNLHEL-DQEYPQYWPDH--GATKYGHIGVSVLSKQEKG-DVICTKLKVTRKKVrRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQCgNAPV
..  |   ..  .|||.   | ...|.| | . ....|  ..| ..|..| ..  ..|..| .... .|||. .|. . |||.|| ....|...  ..|.
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpi

LVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYF
.|.||.||||.|||..|...|..|..|. .|.|...|..| . ||.|.. .||||.|..| .|.
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 307-590 8.1e-71 233.3 In-house 2-285 (287) alignment 
Range on Protein: 307-590
Range on HMM: 2-285/287.0
IPIALFPEYVAKMQANGGIRLENEYKKFNNGQQFPWEAARK--PANKNKNRYANIVAYDHSRVVLErvngDEDSDYINASFIHGYDGTpRSFIASQGPLP
||.  | |.||| .|.|    .| .. ... .| . |   .  . ||.|||...|. .|  ||.|.    .|. |||||.|| ||    . ||....|. 
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykek.kafiiaesPmf

PAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKI-ETYGGVTVTLHQSEIFADYEIRTFILSKAK-RSGSRMVRQFHFTVWPDKG-VPQYATAV
 .   ||......| . ||||... |  . .|..|||..   ..|  ...| . |. |.| .|.. . . .  .  ..|.|...| |...| |....| .
ntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtil

LAFRRKVRALNPRDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEI
| . .....   |  ....||||..| |..... ..  ....|.  ..|. . |   |  .|..||| ||| ||  .||| |....|  
lvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetys
0043336 (Phosphotyrosine protein) phosphatases II 607-876 9.1e-71 233.9 In-house 15-277 (278) alignment 
Range on Protein: 607-876
Range on HMM: 15-277/278.0
RKFQMTGYALEFQRLNSVTSreipaEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVT
 .   |.. |||..|.|..      ...|... |.| .|||..||......|| |...  |. |||||| ..  ..  ..|||||.|| |||||||||| 
llnlktllllefeellsfkl.....dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvw

DYDIGTIVMLNNLHELD-QEYPQYWPdHGATKYGHIGVSVLSKQEKGDVICTKLKVTRkKVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQ
.... |||||..| ||. . . ||||  | ..||.. | .|. ....|.. ..|.||. .   ....|.|.|...||| ..||   ..||.| .... ..
elgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtn.lgdgesrtvthyhylgwpdhgvpeslsllldflkavreale

qCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYF
   | |||| ||.||||.|||.|.  .||.|..|. .|.....|..|   ||||..| || |.|.... |.
.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_PTPN3_pd Subfamily PTPN3 339-582 2e-69 228.6 In-house 30-274 (280) alignment 
Range on Protein: 339-582
Range on HMM: 30-274/280.0
QFPWEAARKPANKNKNRYANIVAYDHSRVVLErvngDEDSDYINASFIHG-YDG--TPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTK
.   .|||||.| .|||| .|..||. || |.    ....|||||...    ..  .   .||.||||. . . ||.|||||.|. |||||.||| |..|
glaisaarkpenlsknryrdilpydatrvklk....esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvk

CHKYWPDKIE--TYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVERTGTY
||.|||.. .  .||. .|......    | .| ..|.... . .|.. |. .. |||.|||. .. .| | ..||.|   .  ||.||||||..||| .
ChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvl

IVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
|...  |    ... | . . .  .|  |  .|||..|| |.  |.|..
illetalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 305-606 2.2e-69 228.8 In-house 2-259 (392) alignment 
Range on Protein: 305-606
Range on HMM: 2-259/392.0
KPIPIALFPEYVAKMQANggIRLENEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLP
.|||.| || .| | . .    . .|.. . . . .|  .|.|. |..|||| ||. || .||.|| ..   ||||.|||.|...|   ...|||||| .
qpipvaqfpafveknrhs..alffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdne.kayiasqgpna

PAFEGFWRMVWEQNSQSIVMLTNLVELGktkchkywpdkietyggvtvtlhqseifadyeirtfilskaKRSGSRMVRQFHFTVWPDKGVPQYATAVLAF
 ... |||||...|  .|.|.|.| |                                           |    | | ||||| ||||.||......| |
aslddfwrmvfqenvttiamvtklkegd.........................................kgddartvaqfhftewPdkdvpkhtssllkf

RRKVRALNPRDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSETYNQAMQKLAS
 ..|.|   . . |.|.|||||| |||  | ||... .|||.| ||. |..  .|. ||.||||||||.||. |||| |   || |    . . .|.| .
ikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlst

VN
  
ss
subfamily_PTPN1_pd Subfamily PTPN1 335-590 4.4e-69 227.4 In-house 17-280 (290) alignment 
Range on Protein: 335-590
Range on HMM: 17-280/290.0
NNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERvngdEDSDYINASFIHgYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKT
.. ..|| ..|..|.|.|.||| ..  |||||..|||    .| ||||||...  .   ||.| .||||| . . ||.|||||.|...||| ..|| ...
keasdfptreaklpenrnlnryrdvspydhsrikler....adndyinaslve.leeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqi

KCHKYWPDKIE----TY--GGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRAL--NPRDAGPVIVHCSAG
||..||| . |    ..    ..|.| . |.   | .|.. | . |   .| . .||.| ||| |||.  .| | |  |||      .| ||...|||||
kcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaG

VERTGTYIVIDAMLEQAKKSR---TVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTC--GNTEI
. |.||....|..| . .|.    .|||.. |..||| |  ..||..|  | . |.||   .  |.. .
iGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdssv
Y_phosphatase Protein-tyrosine phosphatase 642-873 5.8e-69 227.5 Pfam-A 1-234 (235) alignment 
Range on Protein: 642-873
Range on HMM: 1-234/235.0
NLHKNRFSDIIALNSCRVMLhnEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHEL-DQEYPQYWP--DHGATKY
|..|||..||.. .. || |  .. ...|||||| ... ..  ..|||||.|| .|.|||||||..... .||||..| |  .....||||  ... ..|
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GHIGVSVL--SKQEKGDVICTKLKVTRKKVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQqQCGNAPVLVQCSNGVGRSGTFCAISSVLERL
|.| | .   .|... ... .||... || .....|| .||. .|||...|| . |.|||... ..|. .  ..||.|.||.||||.|||.|.. .||.|
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

KTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQ
..|. .||.|..|..| . ||.|.| .|| |.|..|.
eaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 642-873 5.8e-69 227.5 In-house 1-234 (235) alignment 
Range on Protein: 642-873
Range on HMM: 1-234/235.0
NLHKNRFSDIIALNSCRVMLhnEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHEL-DQEYPQYWP--DHGATKY
|..|||..||.. .. || |  .. ...|||||| ... ..  ..|||||.|| .|.|||||||..... .||||..| |  .....||||  ... ..|
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GHIGVSVL--SKQEKGDVICTKLKVTRKKVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQqQCGNAPVLVQCSNGVGRSGTFCAISSVLERL
|.| | .   .|... ... .||... || .....|| .||. .|||...|| . |.|||... ..|. .  ..||.|.||.||||.|||.|.. .||.|
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

KTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQ
..|. .||.|..|..| . ||.|.| .|| |.|..|.
eaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Ptp69D_pd Subfamily Ptp69D 612-877 1.4e-67 223.0 In-house 22-287 (307) alignment 
Range on Protein: 612-877
Range on HMM: 22-287/307.0
TGYALEFQRLNSVtsrEIPaEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIG
 |.| |...|..    ||.  . .|.|.  |. |||. ||.| .. ||.|..   .|.|||||| |..... .. ||| | |. .|..|||||... .. 
fglakeyekLear...eid.kstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevt

TIVMLNNLHELDQE-YPQYWPDHGATKYGHIGVSVLSKQEKGDVICTKLKVTRKKV----RRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQ
.|||| || | ...  ..|||.   ..||.| | . |.....| |  .|.|..||       ....|   |. .|.|  .|| | ..|.|.....  ...
livmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykl

CgNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFD
  ..|..| ||.||||||.| |..|.|..||.|. .|.|...| .| . .  |.|  || |.|. . .| .
n.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 609-875 1.5e-67 222.7 In-house 18-278 (288) alignment 
Range on Protein: 609-875
Range on HMM: 18-278/288.0
FQMTGYALEFQRLNSVTSReipaEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDY
 . ||.  |.. | .. .     .....|....| .|||. .|....  || |.. .  ...||||| ... .......|||| || .||.|||..| ..
rnrtgfseeynsLaalekt....ksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyen

DIGTIVMLNNLHELD-QEYPQYWPDHGA-TKYGHIGVSVLSKQEKGDVICTKLKVTRKKVRRktqEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQ
.. |||||..| | . ..  .|||| .  ..||.. | .....|..|..  || . .|| ..   |. .... .|||. .|| .  .|.||.  ....|.
ktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkktel...eitqyqylaWpdhgvPeskapllellrqvkvanqa

CgNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKY
    |..|.||.||||.||| |.  .......|..|||. .....| . .  |.  .|| |.|... . 
d.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsl
0042113 (Phosphotyrosine protein) phosphatases II 635-876 3.2e-67 221.8 In-house 2-243 (245) alignment 
Range on Protein: 635-876
Range on HMM: 2-243/245.0
SVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQE-YPQYWPDH
||.. | | .|||.|||......|| | ..  |. |||||| . . .|  . |||||.|| |||||||||. ...| |||||....||... ..||||..
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

GATKYGHIGVSVLSKQEKGDVICTKLKVTRkKVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQCGNAPVLVQCSNGVGRSGTFCAISSVL
. ..||.. | .|| . ..|.....|.||. .   ...||.|.|...||| ..|.|  ..||.|..... .....| |||| || ||||.|||.|.  .|
esltygdftvtllseehlddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylml

ERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYF
|.|..|. .......|..|   ||||..| || |.|.......
eqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_PTPN13_pd Subfamily PTPN13 329-584 3.4e-67 221.6 In-house 15-270 (273) alignment 
Range on Protein: 329-584
Range on HMM: 15-270/273.0
NEYKKFNNGQ-QFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGdedsdYINASFIHGYDGTP-RSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLT
.|.|.... . .   | ..| .||.|||| |.. ||..|| |.   |     |||||.|.   |    ..||.||||| . . ||.|||||... |.|.|
eefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvt

NLVELGKTKCHKYWPDK----IETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPrDAGPVIVH
. .| || |||.|||..    .  .. ..|.| . .   .. .|.. ... . . || | ...|. ||| |||. |. .| | ..|| |.  ||||..||
lekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvh

CSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALT
||||. |.||.|.||..|.  .. . .|... .  ||. |  .||||.|| |.. |.||.|.
csaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_PTPRN_pd Subfamily PTPRN 326-582 4.5e-67 220.8 In-house 30-291 (297) alignment 
Range on Protein: 326-582
Range on HMM: 30-291/297.0
RLENEYKKFNNGQQFP--WEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIV
|||.|.. . . .. |   |.|... | .|||......|||||| |.. . .|.|||||||.|   |    ..||.||||.     ||.||||| .  ||
rlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvviv

MLTNLVELGKTKCHKYWPDK-IETYGGVTVTLHQSEIFA-DYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIV
.||.| | | ..|..||||.  |.|.   | |    |.. || .|.| |   . | .| | ||||  ||..|||  | ..| |||||       . |..|
nltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivv

HCSAGVERTGTYIVIDAMLEQAKK-SRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
|||.|. |||.||.|| .|.. .|  . .||   |  || .||..|.||.|. |. .|| | 
hcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaee
0040439 (Phosphotyrosine protein) phosphatases II 634-876 7e-67 220.9 In-house 3-246 (249) alignment 
Range on Protein: 634-876
Range on HMM: 3-246/249.0
KSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHEL-DQEYPQYWPD
.||.. | |..|||..||......|| |.     . |||||| ...  .  ..|||||.|| |||||||||. ...|..||||..| ||  . . ||||.
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

HGATKYGHIGVSVLSKQEKGDVICTKLKVTRKkVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQC-GNAPVLVQCSNGVGRSGTFCAISS
 | ..||.. | .|| ..|.|.....|..|..    .. .| |.....|||  .|.   ..||....... ....  . |||| ||.||||.|||.|.  
ggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

VLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYF
.||.|..|. .|.....| .|   ||||..| || |.|.......
mleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_PTPRK_pd Subfamily PTPRK 636-872 2.5e-66 218.6 In-house 37-273 (314) alignment 
Range on Protein: 636-872
Range on HMM: 37-273/314.0
VGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELD-QEYPQYWPDHG
.  . .| .|||. ||.| . .||.|.  . | .|||||| .. ...  .|||.||.|| |||.||||.| |..  .||||..| |    .  .|||...
aakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedt

ATkYGHIGVSVLSKQEKGDVICTKLKVTR-KKVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQcGNAPVLVQCSNGVGRSGTFCAISSVL
 . ||.| | ... . . ...   ..|.. ..   ...|| ......|||  .|  | ..|.|. . ..||.. .. ...| ||.| ||.|||.||..||
ev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivl

ERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQII
. ...|.|.|||...| .| . .  ||   || |.|..|
dmieregvvdvfnavktlrsrkvnmveteeqykfiydvi
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 602-884 4.1e-66 217.9 In-house 10-286 (287) alignment 
Range on Protein: 602-884
Range on HMM: 10-286/287.0
LASVNRKFQMTGYALEFQRLNSVTSREipaEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHnehaDEESDYINAVFLHAHRGRNAFIATQHPLLETVEDF
..  ...   .|.   |. |..|| ||   .|  ..  .|| .|||...|.  .  ||.|.    .|. |||||||. ... ..|||... |. .|. .|
fvakghakgnegfknqftvleqvtqre...devthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnf

WRMVTDYDIGTIVMLNNLHELDQEY-PQYWPDHGATKYGHIGVSVLSKQEKGDVICTKLKVTRKKVRRKTQEVCHLHHVSWPDKC-IPELACSVLdLLDE
|... |  . .|||| ...| |.|   ||||.. .. .|.  ...|... . ..|  ||.|..|.   ..|.|   .  .|...  ..| . ..| ...|
WkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtill.viee

AQTSQQQCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFDSFSDYAN
   .|.. ||....| ||..||||..|||.   ... ||| |||||||.|. |.  ||.|   .|| | ..|...| |||. |..
myktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysd
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 607-882 7.5e-65 213.6 In-house 15-289 (290) alignment 
Range on Protein: 607-882
Range on HMM: 15-289/290.0
RKFQMTGYALEFQRLNSVTSReipaEEKSVGEEPQNLHKNRFSDIIALNSCRVMLH--NEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRM
.. ...|.  .|..|.|  |     ..  ||  ..| ..|||..|.  .  |..|.  ..| | . .||||.... .. ....|||| |. .|. |||..
hakgnegfrnqfkmldsgese....htvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkl

VTDYDIGTIVMLNNLHELDQE-YPQYWPDHGATKYGHIGVSVLSKQEKGDVICTKLKVTRKKVRRKTQEVCHLHHVSWPDKC-IPELAcSVLDLLDEAQT
. . ..  |||| |  | ...   |||||.....||.. . .|. ..  . | .||.|. |.   ..|.| ...  .|...  ... . ..| .. | . 
iwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpq.tillvieemyk

SQQQCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFDSFSDY
 | . || ...| ||..||||..|||.   ... |||.|||||||.|. |.  || |..  || . .||. .|.|||. |
tqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 314-595 1e-64 213.7 In-house 9-291 (439) alignment 
Range on Protein: 314-595
Range on HMM: 9-291/439.0
EYVAKMQANGGIRLENEYKKFNNGQQ-FPWEA--ARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPAFEGF
|.| |.. |    ......| |  .  .  .|  | .  .. |||| ...|.||.||.|. . |   | |||| .|.||  ... .||.|||   . . |
ehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyy.ddklyiatqgpkkettddf

WRMVWEQNSQSIVMLTNLVELGKtkchkYWPDKIETY-GGVTVTLHQSEIFADYEIRTFILSKAKR--SGSRMVRQFHFTVWPDKGVPQYATAVLAFRRK
||.|.|...  |||||||||  |     ||| . |.. | ..|   .   . .| || | . . .      | | |||.. |||| ||  |. || | | 
wrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflra

VRALNP-RDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSETY
. . |  .. |||.||||||| |||| | .|  ||| |    |||.  .  |||.| .|||.  || ||. |||| .  |.. .. . .
insandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidef
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 344-581 1.7e-64 212.4 In-house 14-262 (270) alignment 
Range on Protein: 344-581
Range on HMM: 14-262/270.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK
      .|. ||||.|.   ..||.||... |. . |||| ...|.|| ....||..|||| . . ||||.||.....|||.|.|.| |..|| .||| .
lpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpae

IET-----YGGVTVtLHQSEIFADYEIRTFILSKAKRSGSRMVrQFHFTVWPDKGVPQYAT------AVLAFRRKVRALNPRD--AGPVIVHCSAGVERT
 ..     .| ..| | .||  ..  |.| .  . | .  |.|  |... |||.|||. .        .|.  |.||. . .   |.|..|||||||.||
pkekvkledgkikv.lalseekeegyiltrlrleekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRt

GTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
|| |..| ...  .... ||. . . .|||||. .||. ||| |.. ||.|
GtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_CG7180_pd Subfamily CG7180 344-587 3.7e-64 211.2 In-house 36-294 (296) alignment 
Range on Protein: 344-587
Range on HMM: 36-294/296.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKtKCHKYWPDK
.. .  |..|||. ..| ||. |||||...|.|.||||||... ..   .. .|  ..|   . . |||.|........|.||.  .  | ....||| |
gglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsfl.kkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnk

-IETYGGVTVTLHQSEIFADYEIRTFILSKA----------KRSGSRMVRQFHFTVWPD-KGVPQYATAVLAFRRKVRALNPRD-----AGPVIVHCSAG
  | || . | . ... .|. .|||| | |                |.|..|..|.|.  . ||  ..|.. .||.|| .  .       |||.|..| |
skeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdG

VERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGN
. |.| |. ||| ||...|   ||. ...  ||..||..|...|.| .|   .|||. |. 
asRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk
0045098 (Phosphotyrosine protein) phosphatases II 632-876 4.1e-63 208.7 In-house 23-272 (278) alignment 
Range on Protein: 632-876
Range on HMM: 23-272/278.0
EEKSVGEEPQNLHKNRFSDIIALNSCRVMlhnehadeesDYINAVFLHAHrgRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHEL-DQEYPQYW
 | ...  . ||.|||..||......||           ||||| ... .  ...|||||.|| .||.|||||. ...| .||||..|.||  . ..|||
seitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqyw

PDHGATKYGHIGVSVLSKQEKGDVICTKLKVTRK---KVRRKTQEVCHLHHVSWPDKCIPELA--CSVLDLLDEAQTSQQ------------QCGNAPVL
|..|   ||.. | .|| .. .|.. ..|.||     .   .. .|.||| ..||| ..|.|    |.|.||.. .  ..            . .. |||
peggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvl

VQCSNGVGRSGTFCAISSVLERLktEQVIDVFQVIKRIRVNLPG-AVESPTQYLFCYQIIQKYF
| || ||||.||..|.  .||.|  |...|.....| .|   || ||... || |.|. .....
VHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 637-875 1.1e-62 206.8 In-house 44-278 (315) alignment 
Range on Protein: 637-875
Range on HMM: 44-278/315.0
GEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQEYPQ-YWPDHgA
  . .| .|||. .||| .  || |     |..|||.|| |.  .  .. .||.| |. ..|.||||.| ..|||.||||.|| | ...  . ||||.  
akkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.k

TKYGHIGVSVLSKQEKGDVICTKLKVTRKKvrrKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQCGnAPVLVQCSNGVGRSGTFCAISSVLER
  ||.| |.  |.. . .. .  | |. ..   . .||  ||. ||||  .|. . ....|   ..  ...   ....| ||.||||.|||.....||..
viyGkitvtrkseevnteytvrtlsvvfgd...nirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavldq

LKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKY
...|..|||...|...| |  ..|..  || | |... . 
aeaenaidvynfitgvrqnrikmvqvaeqyqfiydallet
subfamily_PTPRG_pd Subfamily PTPRG 612-876 1.7e-62 206.5 In-house 19-287 (563) alignment 
Range on Protein: 612-876
Range on HMM: 19-287/563.0
TGYALEFQRL-NSVTSREIPAEEksvGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEES-DYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYD
.|.. ||. | . ..|....||     ..|.| .||| ..|.| .. || |..    ... ||||| ... ..  .||||||.|| .|..|||||. .  
igfseefealqsetiskdldaeh...sqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqn

IGTIVMLNNLHEL-DQEYPQYWPDHGATKYGHIGVSVLSKQEKGDVICTKLKVTRKKVRRKT-----QEVCHLHHVSWPDKCIPELACSVLDLLDEAQTS
  .|||. || |   .. ..|||  .. .||.. |   ... .      .|..   |...|      ..| . |  .|||.. || .  ||     ....
vaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaa

QQQcGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYF
...    |..| ||.||||.||.......|.....|....||...|.|| . .  |..  ||.| ......  
nka.eaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleai
subfamily_PTPRB_pd Subfamily PTPRB 591-877 4.5e-62 204.7 In-house 8-286 (293) alignment 
Range on Protein: 591-877
Range on HMM: 8-286/293.0
QSETYNQAMQKLASVnrkfQMTGYALEFQRLNSVTSREipaeEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIAT
. |.... ..|...     . .... |...|..| . .    .... |...|  |||...|.. .  || |.. . ...|||||| ... .. .. ||||
klekfeehvkkmkad....sdlrfseeyeelkavgkdq....avkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiat

QHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ-EYPQYWPDH-GATKYGHIGVSVLSKQEKGDVICTKLKVTRkkvRRKTQEVCHLHHVSWPDKCIPE
| || |||.|||||| .    .|||| .| |  .    .|||..  .. ||.| |......|. | .. .||...   ......| ..|..||||  .||
qGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPe

LACSVLDLLDEAQTSQ-QQCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFD
 . ..||.. . .... ... ..|..| || ||||.||| |.  .|.....|...|.| .. ..| .    | . .||.| .| ..... 
ktktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_PTPN12_pd Subfamily PTPN12 612-877 6e-62 204.1 In-house 8-278 (290) alignment 
Range on Protein: 612-877
Range on HMM: 8-278/290.0
TGYALEFQRLNSVTSREIPAE--EKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYD
  .| |||.| .....    .  ....||...| .|||. ||.  .  ||.|.... .|.|||||| |..   |. ..||.| || .|..|||||. ...
eefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiwekn

IGTIVMLNNLHELDQEY-PQYWPDHGAT--KYGHIGVSVLSKQEKG-DVICTKLKVTRKkvrRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQ
.  .||. .. ||..    .|||..| .  ..|.. |.. ...    | .   |||...   .....|  .|. .|||. .|. | |.|.|...... |.
veivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe

qCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQV---IDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFD
   .||..| || |||| || .||  | | ||.|..   .|||... ..| . . .| .  || . |. . ... 
.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 634-878 3.2e-61 202.0 In-house 43-286 (297) alignment 
Range on Protein: 634-878
Range on HMM: 43-286/297.0
KSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGrnAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQEYPQYWPDH
. | |.  |..|.|...|.  .| ||.|.    | .|||.|| |... .    .|.|| |  .||.|||.|| |... ||||||...| |..  .||.|.
qtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdk

GATKYGHIGVSVLSKQEKGDVICTKLKVTRKKVrRKTQEVCHLHHVSWPDKCIPE--LACSVLDLLDEAQTSQQQCGNAPVLVQCSNGVGRSGTFCAISS
| |..|.. | .|| .|.   |  .|.||. |  .... |   ..|.|||| ...   | |.|.|..| . . .|  ..|.|| |..|||| | ...| |
gvttfGdvsvvllsvsereGfikrelevtkgka.karrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltids

VLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFDS
|. . | |. .|.|...|..| . |  |    || | |... ... |
vvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlealls
0037934 (Phosphotyrosine protein) phosphatases II 637-876 7.8e-61 201.0 In-house 5-242 (243) alignment 
Range on Protein: 637-876
Range on HMM: 5-242/243.0
GEEPQNLHKNRFSDIIALNSCRVMLhnehadEESDYINAVFLHAHrGRnaFIATQHPLLETVED----FWRMVTDYDIGTIVMLNNLHEL-DQEYPQYWP
.  |.||.|||.|||....  || |      | |||||| .     .|  .||||.|| |||||    ||||. ...|..||||..| ||  . ..||||
allpenlsknrysdilpydhsrvkl......egsdyinanliyvt.pr..liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

dhGATKYGHIGVSVLSKQEKGDVICTKLKVTRKKVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQ-------CGNAPVLVQCSNGVGRSG
  | . ||.. | .|| ....|.. ..|......    |..|.|.|...||| ..|.   ..||.|||... ...        .. |||| || ||||.|
..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtG

TFCAISSVLERLkteQvIDVFQVIKRIRVNLPG-AVESPTQYLFCYQIIQKYF
|..|.  .|..|   . .|.....|..|   || ||..| || |.|.......
tliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 611-876 8.3e-61 200.9 In-house 22-288 (325) alignment 
Range on Protein: 611-876
Range on HMM: 22-288/325.0
MTGYALEFQRLNSVTSReipaeEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDI
  |.| ||. | |. .       | |   |.|  |||| ...||.  ||.|   . | .|||||| .|. ..... |.|.| || .|..|.||.| |.  
qdgfahefgllpsddgi.....akkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrc

GTIVMLNNLHELDQEYPQYWPDH--GATKYGHIGVSVLSKQEKGDVICTKLKVTRKKvRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQ---Q
  .|.|| | . ...  .|||..   . ..| . |.. . .|  | .  .|.| . | . .|. |  ... ||.|   ..  .... .|.  .. .   .
svvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvk.kGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservt

--QCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYF
    . .|.|| ||.||||.|.| .. |.|... .|  .|.|...|..| . |  ||.  || ..|. . ...
antkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_PTPN23_pd Subfamily PTPN23 328-582 3.6e-59 195.0 In-house 18-279 (288) alignment 
Range on Protein: 328-582
Range on HMM: 18-279/288.0
ENEYKKFNNGQQ-----FPWEAARkpANKNKNRYANIVAYDHSRVVLErvngDEDSDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSI
....|.... |.     .   .|.   . .|||. .|. |||.||.|.    ..  |||||||...   .  .|||.|.||...   ||.||.|| |. |
dkkfkeleqkqdkearkrsiaiak..lyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssvi

VMLTNLVELGKTKCHKYWPDK---IETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRA----LNPRD
|||..  ||||.|...||| .    ...| ..|||.. .    .  |...|.  . .  ..|.  ..| ||. |||.    .|.|  .|..     . . 
VmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrks

AGPVIVHCSAGVERTGTYIVIDA-MLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
  |..|||||||.|||.. .. | . |  |.   .|| . .  ||..| .|||.|||. |  .|||||
ktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 320-589 9.8e-59 193.5 In-house 13-299 (301) alignment 
Range on Protein: 320-589
Range on HMM: 13-299/301.0
QANGgirLENEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNG--DEDSDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMVWEQ
..|.   .|..||. ..|.. . .   . .||. ||. ||. ||. |..|.  .       .|||||.|.||  . . |||.|||.      |||..|..
hsnk...feeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysek.kkfiaaqgpmkktlvdfWrliwqe

NSQSIVMLTNLVELGKTKCHKYWPD---KIETYGGVTVTLHQSEIFADYEIRTFILSKA---------------KRSGSRMVRQFHFTVWPDKGV-PQYA
  .||||.||| |  |.||..|||.   . |..| .||||... .. |. || . .                  ..  |. | |.. | ||. || ....
kpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvrepr

TAVLAFRRKVRALNPRDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTE
| . .    . . .  . |||.||||..| |.|.|. ..  |||.|    ||. .   |.|. .| .|.| |||..|. .. . |.. .|.
tvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnsty
subfamily_PTPN9_pd Subfamily PTPN9 631-875 6.8e-58 191.0 In-house 31-289 (297) alignment 
Range on Protein: 631-875
Range on HMM: 31-289/297.0
AEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ-EYPQY
. .  . . . ||.|||..|.. ... ||.| ... ||.|||||| |.  .. ..|||||| || .||.|||||| . .. .|||   . |  .    ||
eGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqy

WP--DHGATKYGHIGVSVLSKQEKGDVICTKLKVTRKKVrRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQ------------QQCGNAPVLVQ
||  .. ....|.. ||... .|. |   ..|.... |  .....| |   .||||  .|. | |.||.|....  |             .. . |..| 
Wpleeessaefgdlsvsnveveeeedykvrvleiknvkt.eesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvh

CSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKY
|| |.||.|||...   |.||......||....|..|     ..  | || |||. .  |
csaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 629-876 1.3e-57 190.1 In-house 31-277 (315) alignment 
Range on Protein: 629-876
Range on HMM: 31-277/315.0
IPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ-EYP
 .. .. |. |..| .|||. .|. |.| ||.|     . .|||||| ....    .|.||.| ||  .|.|||||| .... ||||.....| |. .  
PdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcr

QYWPD--HGATKYGHIGVSVLSKQEKGDVICTKLkVTRKKvrRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSqQQCGNAPVLVQCSNGVGRSGT
|||||    ....| | |..|| .  .| .  || ||||    ... |   .   |||| ... . |.| |. | ... ..  . ..|| || ||||.| 
qywPdrkadsvefGsikvellsleadtdgvarkl.vtrks..eesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGv

FCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYF
...| .|....| ....|||...| .| . |  | .  .| | |.......
visidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 605-877 2.4e-57 189.2 In-house 8-277 (281) alignment 
Range on Protein: 605-877
Range on HMM: 8-277/281.0
VNRKFQMTGYALEFQRLNSVTSREIpAeekSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRM
 ... . .|.. |.. |...  ..  |   .  ....| .|||.|.|.| .  || ..........||||| |. . .| ...|||| |. .....||.|
qlsqndnaGfieeyeklaaigvdnt.a...taskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqm

VTDYDIGTIVMLNNLHELDQ-EYPQYWPDHG-ATKYGHIGVSVLSKQEKGDVICTKLKVTRKKvrRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQT
| .... .|||. .  | ..    .||||.  ..|||.. |. ....||   |. |.|..|..   .|.|| .|....|||. .|. .  .|.  .| . 
vweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleres..getreveqlaytaWPdhGvPattkellefrkevlk

SQQQCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTE-QVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFD
 ...  .||... || ||||.||. |.  .......| . .|| .|.. .| .    | . .|| | |... ...|
ltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 611-881 4.5e-57 188.7 In-house 33-297 (319) alignment 
Range on Protein: 611-881
Range on HMM: 33-297/319.0
MTGYALEFQRLnsvTSREIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDI
.| .  ||.|.   . . ..  ...  . .||  |||. .|.| .  .| |..    | |||||| |.  .. .. .||.| || .|..|||||. .|..
ltklevefrra...cklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweync

GTIVMLNnlhelDQEYPQYWPDHGATKYGHIGVSVLSKQEKGDVICTKLKVTRKKVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDE-AQTSQQQCGN
 |||.|       .   |||| ..  |...  |.| | .|  . .  .......   .  ...   |   |||.  |. .  .. |..      ... ..
stivllt.....kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhr

APVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQK-YFDSFSD
|...| || ||||.|.. ..  .|.|.| |. .||..... .| . .  |.. .|| |.|  . . .. ..||
anivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsd
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 634-875 1.8e-56 186.3 In-house 35-275 (515) alignment 
Range on Protein: 634-875
Range on HMM: 35-275/515.0
KSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQE-YPQYWPD
..| .|  | .|||. .|. ..| || |   . . .|||.|| ....    .|.||.| |.  .|.||||.| .... ||.|...|.| |.    .||||
qtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPd

--HGATKYGHIGVSVLSKQEKGDVICTKLKVTRKKVrrkTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQCGnAPVLVQCSNGVGRSGTFCAIS
    . |.|.| |...| .  .. |  ||.|.. .    .. |   |   |||| .|. . |.| |. | .....|    |... || |||| | ...| 
kpgdsvkfGsikvelvsleactggikrkltvlkgdd...srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtGvvisid

SVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKY
||. . || ...|||.... || . |  |    || | |.... .
svvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavled
subfamily_PTPN6_pd Subfamily PTPN6 588-878 1.9e-56 186.3 In-house 2-299 (306) alignment 
Range on Protein: 588-878
Range on HMM: 2-299/306.0
TEIQSETYNQAMQKLASVNRKFQMTGYALEFQRLNSVTSREIpaEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHnEHADEESDYINAVFLH--AHRGRN
|.. ... .| ...|   . ... .|.  ||..|.   ...    ... |. |.| .|||.  |.  .  ||.|. |.   .|||||| ...  ..  ..
tsllakeieqrvselekeeeslekagfeeefeelqqeeakkl..lsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdk

AFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ-EYPQYWPDHGAT-KYGHIGVSVLSKQEKGDVICTKLKVTRKKVRRKTQEVCHLHHVSWPD
..||||  | .||.|||||| . .   |||. .  |  .    .||||. .. .||.| |. .|.... | |  .|.|..||  ....|| ..|. ||||
syiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPd

KCIPELACSVLDLLDEAQTSQQQCG---NAPVLVQCSNGVGRSGTFCAISSVLERLKTE---QVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFD
. .|.    |||.|.. .. |...    . |..| ||.|.|| |||  |  .|. ....     ||. ...| .|    | |   .|| | |..|.|| .
hgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyie

S
.
t
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 626-881 4e-56 185.6 In-house 9-261 (284) alignment 
Range on Protein: 626-881
Range on HMM: 9-261/284.0
SREIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNnlhelDQE
 . ... ...  . .||  |||. .|.| .  .| |..    | |||||| |.  .. .. .|||| || .|..|||||. .|.. |||.|      .. 
klgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.....kdk

YPQYWPDHGATKYGHIGVSVLSKQEKGDVICTKLKVTRKKVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDE-AQTSQQQCGNAPVLVQCSNGVGRSG
  |||| ..  |...  |.| | .|  . .  .......   .. ...   |   |||.  |. .  .. |..     .... ..|...| || ||||.|
csqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtg

TFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQK-YFDSFSD
.. ..  .|.|.| |. .||..... .| . .  |.. .|| |.|  . . .. ..||
vyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsd
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 334-580 5.3e-56 184.5 In-house 22-274 (287) alignment 
Range on Protein: 334-580
Range on HMM: 22-274/287.0
FNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLErVNGDEDSDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGK
  ..  . . || . |. .|||||... .|..||.|   .|.  |||||| .. .|     .|||.|||.. .   |||.|.|..| |....|  || ..
dsesstatfkaaeelaavkknryadvlPiddtrvlls.aegelGsdyinanyvasytdd.eafiaaqgPiaatvrdfwravletrsasvitmtreveear

TKCHKYWPDKIE--TYGGVTVTL-HQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKV-----RALNPRDAGPVIVHCSA
 ||.||||..      || .|.|  ..    .| .|.. | ...   .|.|.|...  ||||...  | ... |  .|      | .  ..||..||...
lkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddv

GVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVL
|. |.|... . ..... ..   ||. . .| ||. |  .||.  |. ..  |. 
GiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_PTPRD_pd Subfamily PTPRD 725-883 2.3e-55 183.3 In-house 132-288 (564) alignment 
Range on Protein: 725-883
Range on HMM: 132-288/564.0
EYPQYWPDHGATKYGHIGVSVLSKQEKGDVICTKLKVtRKKVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQqQCGNAPVLVQCSNGVGRSG
.. .|||..| ..||.. |.. ...|. |......|. .|| .....|| . |..||||...|| |.|.|||... .... .... |..|.||.||||.|
kchkYWPekgtetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTG

TFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFDSFSDYA
||..|...|||.|.|...|..|..|..| . .  |....|| |....|... .....  
tfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntev
subfamily_PTPN14_pd Subfamily PTPN14 341-583 3.9e-55 182.0 In-house 40-296 (300) alignment 
Range on Protein: 341-583
Range on HMM: 40-296/300.0
PWEAARKPANKNKNRYANIVAYDHSRVVLERVNgDEDSDYINASFIHGY-DGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKY
  ..|. | |..|||. ... |...|| |   . .....||||| |.    |. ||.|..||||. . . ||.|||||. | |||||.  | ||.|..||
llstaklpenaeknrfkdvlPyednrvelsptk.enstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfky

WPDK-----IETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR---------DAGPVIVHCSA
.|..       ..|   || . ||    .  ... |     .  | |  . .| |||.|||.  .  | . ..|...  .            ||.|||||
fPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsa

GVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
|| |||  |. | ...  .. ...||.. |  ||. | ..|||  || |....... |
GvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_CG7180_pd Subfamily CG7180 610-876 8.9e-55 180.4 In-house 11-290 (296) alignment 
Range on Protein: 610-876
Range on HMM: 11-290/296.0
QMTGYALEFQRLNSVTSReIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYD
..  . .|.. .  .|.| .  ..   | . .|. |||  ...  .  ||.|.. . .|.|||||||.  ..   ...| |. |  |||..|||.| | .
krrkfrveyklelkltpr.leigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydee

IGTIVMLNNLHELDQEYPQYWPDHGATKYGHIGVSVLSKQEKGDVICTKLKVTRK---------KVRRKTQEVCHLHHVSWPD-KCIPELACSVLDLLDE
| ..|.| .  .  . ||.||| .. ..||.| | ......  ..   ..|.|.|         .|  .|  |....   |.  . .|  . ....|.  
isavvvLtktfdfakmypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrr

AQTSQQQC----GNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYF
... ...      ..||.| .|.|..||| ..||   || .. |. .|||. .|..| . |. ||. ..| ..|.......
vrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 640-877 3.2e-54 178.8 In-house 26-269 (274) alignment 
Range on Protein: 640-877
Range on HMM: 26-269/274.0
PQNLHKNRFSDIIALNSCRVMLHNEHADEE-SDYINAVFLHAHRG-RNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ-EYPQYWPDHGAT
. . .|||. .|.  .  ||.|..|....| |.|||| ...  ..  .|..||| || .||.|||||.   ..  |||| .|.| ..    .|.||.  .
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

----KYGHIGVSVLSKQEKGDVICTKLKVTRKKVrrkTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQCG--NAPVLVQCSNGVGRSGTFCAIS
    .||.. . | .. |. |   .|| .   .    ...| |  . .|||.  |. | ..|||..| ..|...     |||.| || |.|| | | |||
eiserygdveikvekiverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiais

SVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFD
  . .|. |.|.||....  .|..  | |..  || . .... .|  
iavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
0051429 (Phosphotyrosine protein) phosphatases II 378-602 4.9e-53 175.8 In-house 4-243 (272) alignment 
Range on Protein: 378-602
Range on HMM: 4-243/272.0
SDYINASFIHGYdGT---PRSFIASQGPLPPAFEGFWRMvWEQNSQSIVMLTNLVELGKTKCHKYWP-------------DKIETYGGVTVTLHQSEIFA
|.||||... || |    |. ...|.||||   ..|||. .|..  .||.|....|.|. ||..|||             .   .|| ..|||.. |.. 
sgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

DYEIRTFILSKA-KRSGSRMVRQFHFTVWPDKGVPQYAtaVLAFRRKVRAlnprdAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVD--------IR
|| .|...|..  . . .|.|...|.| ||| |||| |  .|.. . ...      |||.||||||. ||||..... .|..  ..  ||        ..
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyle

NYLIALRKDRPHMVQTKEQYSFIHSAVLEAlTCGNTEIQSETYNQAMQKL
...  ||. ||..||| ||| |.. |.||.  .. .... |....|.. .
eaveelraqrpgavqteeqylflyeallel.lrsllsvraeyllaaldai
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 632-884 1e-52 173.8 In-house 30-301 (301) alignment 
Range on Protein: 632-884
Range on HMM: 30-301/301.0
EEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHA--DEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHEL-DQEYPQ
.. .|| . .| . ||| .|  ..  |..|.....    . .|||| .... . ...|||.| |. .|. ||||.. ..   .|||. ||.|   ..  |
ksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceq

YWPDHGATK--YGHIGVSVLSKQEKGDVICTKLKVTRK--------------KVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQCGNAPV
|||.  |..  .|.. | . ..|   | .  .|.|. .              | ......|  |. ..||.  .      ||  .|.    ||. | .||
ywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpv

LVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFDSFSDYAN
.| ||..|.|||..|..|  ||  | | |.|||||.|..| . ||||    || . |..|..|.   | |||
vVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstyan
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 342-591 1.3e-52 173.5 In-house 25-274 (283) alignment 
Range on Protein: 342-591
Range on HMM: 25-274/283.0
WEAARKPANKNKNRYANIVAYDHSRVVLERVNGdedsDYINASFIH--GYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKY
 . |    ||.|||. .||..|  || |.  .     |||||.||     .   . .|..|.||  .   ||.||....  .|||||.| |  . || .|
adiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqy

WPDK-IETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRM-VRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVERTGTYIVID
|| .  | ||  ||||..      . |. ..| .   . | . .  . .  | . |      ... | . .   .    ||..||||.|. ||...| . 
WPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaas

AMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQ
| ...|. .  ||. . .  .|..|. .|||..|| ..| .|||   ||.|.| 
asvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqia
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 612-872 7.2e-52 171.0 In-house 6-262 (283) alignment 
Range on Protein: 612-872
Range on HMM: 6-262/283.0
TGYALEFQRLNSVTsreIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHAdeesDYINAVFLH---AHRGRNAFIATQHPLLETVEDFWRMVTDY
... | ...|. ..   .|  .  .    .| .|||. .|.. .  || |..|      |||||||.     ..  . .|..| || .|| |||.|| | 
nnnklfrevlkrls...vpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfde

DIGTIVMLNNLHE-LDQEYPQYWPDHGATKYGHIGVSVLSKQEKGDVICTKLKVTRKKVRRKTQEVCHLHHVSWpDKCIPELACSVLDLLDEAQTSQQQC
.| .|||| .| | |...  |||| .|. .||   |..     .   |  .| .  .   ..|  ..|   . |  .. ..     |  ..  .. |.. 
kitaivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW.leygeqaiinslvkfnkvislqtes

GNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQII
 ..|..| ||.|.||...|.|.|. .. ..|| |.|||.|.| .|.....|| .  || . ....
kkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
subfamily_PTPN23_pd Subfamily PTPN23 611-875 4.3e-51 168.4 In-house 14-279 (288) alignment 
Range on Protein: 611-875
Range on HMM: 14-279/288.0
MTGYALEFQRLNSVTSREipAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHnehaDEESDYINAVFLHAH-RGRNAFIATQHPLLETVEDFWRMVTDYD
 |.   .|. |..   .|  |...|.     . .|||. ||.  .. ||.|.    ... ||||| |..    |   ||||| || .|. |||.|| .  
ktaldkkfkeleqkqdke..arkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqk

IGTIVMLNNLHELDQE-YPQYWPDH--GATKYGHIGVSVLSKQEKGDVICTKLKVTRKKVRrKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQT---S
  .|||| . .||...   .||| .   ..|.|.. |.. |..| . ..  .||.. .... ....|.||.  |||.  .|.   ..|..|||...   .
ssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldad.avksvshlqltsWpelGvPasPetllqfldevesayea

QQQCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTE-QVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKY
.|.  ..|..|.|| ||||.|.|. . .... |...  ..|. ||..|.| .    |.  .|. |.|... ..
vqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
0041856 (Phosphotyrosine protein) phosphatases II 350-589 3.9e-50 165.3 In-house 1-177 (182) alignment 
Range on Protein: 350-589
Range on HMM: 1-177/182.0
NKNKNRYANIVAYDHSRvvlervngdeDSDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTnlvelgktkCHKYWPDKIetygg
|..|||| .|. |||||          |.|||||... |.  . | ||| ||||.  .. |.||..|.. ..||.||         .. |||..      
nldknrysdilpydhsr..........dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywpell.....

vtvtlhqseifadyeirtfilskakrsgSRMVRQFHFTVWPDKGVPQyATAVLAFRRKVRAlnprDAGPVIVHCSAGVERTGTYIVIDAMLEQakksrTV
                             |.. |.... ||| |||     .|.| ..|..    . |||.||||||| ||||..... |...      |
............................erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gv

DIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTE
.... .  .|. ||.||.| .|| |.. |.|| | ...|.
sleeavklvrsrRpgmvitpnqyfflqlallellllkktr
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 632-877 1.1e-48 160.5 In-house 10-265 (270) alignment 
Range on Protein: 632-877
Range on HMM: 10-265/270.0
EEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLH-AHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQEY-PQY
.|... |  .. . ||. ||.     ||.|.... |... |||| ... ..  ....||.. ||  |...||||. .    .|||. .|.|  ..   .|
sesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerY

WPDHGA----TKYGHIGVSVLSKQEKGDVICTKLKVTRKKvrrKTQEVCHLHHVSWPDKCIPELAC------SVLDLLDEAQTSQQQCGNA-PVLVQCSN
|| .      ...|.| | .||.. .   | |.|....|    ......| ....|||. .|. .       ..| .| . . |...  .| |.|| ||.
Wpaepkekvkledgkikvlalseekeegyiltrlrleekg...eerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsa

GVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFD
||||.||. |.  ... |.... .|| ..|...| . .  |. | || | |. ...| .
GvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
subfamily_PTPN3_pd Subfamily PTPN3 628-877 1.1e-46 154.0 In-house 27-277 (280) alignment 
Range on Protein: 628-877
Range on HMM: 27-277/280.0
EIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHAdeesDYINAVFLHAHR----GRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELD
  |  . |.   |.||.|||. ||.. .. ||.|.....    ||||| ..          | .|||| || .|..|||.|| . .. .|||| .| |  
kkpglaisaarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverG

-QEYPQYWPDHG-ATKYGHIGVSVLSKQEKGDVICTKLKVTRKKVRrKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQqQCGNAPVLVQCSNGVG
 .   ||||...  ..||.. | . ...|.  ..  .| ...|. . . ... .| ...|||...|. . ..|..... .. . .  . ||.| || |.|
rvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketk.eerkilqlqylaWpdhgvPddsadflefvervrklr.sgkeePvvvhCsaGig

RSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLF-CYQIIQKYFD
|.| . ..   |  . ... . . ......|      |....|| | |  |.. | .
rtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvyee
0036282 (Phosphotyrosine protein) phosphatases II 378-576 1e-45 150.9 In-house 2-163 (174) alignment 
Range on Protein: 378-576
Range on HMM: 2-163/174.0
SDYINASFIHGYDGTPrSFIASQGPLPpafegFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDkietyggvtvtlhqseifadyeirtfilskAKRSG
|||||||.....  ||  .||.||||.     ||.|..|......|||....|||..||. |||.                               . . 
sdyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..............................lredl

SRMVRQFHFTVWPDKGVPQYATaVLAFRRKVRALNPR-DAGPVIVHCSAGVERTGTYIVIDAMLEQAKkSRTVDIRNYLIALRKDRPHMVQTKEQYSFIH
.|.. |.... ||| |||  .. .| | . |.    . . |||.||||||| |||| .... || . . ...||. ... .||. ||.|||| .|| |..
erlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly
subfamily_PTPN13_pd Subfamily PTPN13 612-873 1.2e-45 150.9 In-house 11-266 (273) alignment 
Range on Protein: 612-873
Range on HMM: 11-266/273.0
TGYALEFQRLNSVTsreiPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHAdeesdYINAVFLHAHRGRNAF--IATQHPLLETVEDFWRMVTDYD
   | ||. |. .     | .. .||.. .| .|||. ...  .  || | .| .     |||| ..... | . .  ||.| || |||.|||.|| . .
qqPaeefkelrelk....pldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqk

IGTIVMLNNLHELDQ-EYPQYWPDHGATK---YGHIGVSVLSKQEKGDVICTKLKVTRKKVrRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQ
   |.|. .  | ..    .|||..   |   .. . |..|  |.. .    .|.|. ..  ....|| ||. |.|||  .|  | ..| .. | .. |.
aeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdses.gesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt

qcGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQ
   ..|..| || |.|||||. .|  ||. .. .. .|| ......|    | | .  ||.|.|..| 
..dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykail
0051429 (Phosphotyrosine protein) phosphatases II 670-879 1.4e-45 151.4 In-house 4-228 (272) alignment 
Range on Protein: 670-879
Range on HMM: 4-228/272.0
SDYINAVFLHAHRG---RNAFIATQHPLLETVEDFWRMvTDYDIGTIVMLNNLHELDQEY-PQYWP------------DHGATKYGHIGVSVLSKQEKGD
|.|||| ..    .   .........||  |..||||.  ...| |||.| ...|....  ..|||            ..    ||.. | .||.. . |
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

VICTKLKVTRKKVRRKTQEVCHLHHVSWPDKCIP-ELACSVLDLLDEaqtsqqqcgNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVID--------V
.|...| .|..    .. || |||. .||| ..| |  ...|.|| .         . |||| || |..|.||..|.  .|...  |...|        .
yilrellltlllsagearevmhlhytdwpdhgvpqeallellellld.........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

FQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFDSF
.......|   ||||....||||.|........|.
eeaveelraqrpgavqteeqylflyeallellrsl
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 334-581 5.1e-44 145.0 In-house 40-281 (290) alignment 
Range on Protein: 334-581
Range on HMM: 40-281/290.0
FNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLErvNGdEDSDYINASFIHGydgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGK
.  .|..  .   | .. .|||| ..|  | .||.|.  .|  | ||. | ...|   .   || .||.|  .   .|||| ...   |||| .|.| ||
ylpvqylerkifdkntefkknrykdvvcndktrvilk..dG.ydGdyvhanyvkG...lkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGk

TKCHKYWPDK---IETYGGVTVTLHQSEIFADY-EIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALnprdAGPVIVHCSAGVER
.||..|.|.|   . |.| .||.  ...   .    .|. . . .   . ... ..   |||| |.. . |.|   | .| .    .|||.||||||. |
akceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka....sGpvvvhcsaGiGr

TGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
|||.. |.. |.   . . .|. .   |||. |   ||   ||  .  ..|.
tGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 639-873 9.6e-44 144.5 In-house 45-276 (439) alignment 
Range on Protein: 639-873
Range on HMM: 45-276/439.0
EPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQeypqYWPDHGATKY
.  .  |||. |. |..  ||.|..      | |||| ... .   . .|||| |  ||..||||.| .    ||||| || |  .    |||  . . |
qeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk....ywpsdaevcy

GHIGVSVLSKQEKGDVICTKLKVTRKKVR-RKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQCGNAPVLVQCSNGVGRSGTFCAISSVLERLK
| | | |  . |  . .   .||  .. . .| . | ..|...|||| .|  |  |||.|   ......    ||.|.|| ||||.||  |.   ||.||
gdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlk

TEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQ
.|. .|.  ..| .| .    |..  ||.| |. . 
lenkvdikgivkvlrkqrkqmvqalcqyvfiynavl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 317-598 1.7e-43 143.8 In-house 8-288 (307) alignment 
Range on Protein: 317-598
Range on HMM: 8-288/307.0
AKMQANGGIRLENEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLErVNGdEDSDYINASFIhGYDGTPRSFIASQGPLPPAFEGFWRMVWE
 .    |  .| .|.... . .     .    || .|||| .. . |..|.|.. ..|   |||| | .. |    |. ||..||||  .   || |. .
qrtldkgvqalvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvk.fdg.lasdyihanyl.giaikpkkficaqgplentqysfwamaiq

QNSQSIVMLTNLVELGKTKCHKYWPD---KIETYGGVTVTLHQ-----SEIFADYE-IRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFrrk
.. .|..|| ...||.| ||..|||    .  ..|  . |.        ..  | . |    |     ..|| .... .. |||.||||   . . .   
ekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainl...

VRALNpRDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKS-RTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALtcgnTEIQSETYNQA
. | .  |  ||.||||||| |.|| . |  . ..  .     |... .  ||..|.. .||. || ..|  .|| .     |   |||.. 
leavr.ydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf....lelyketyeel
subfamily_PTPRN_pd Subfamily PTPRN 630-872 1.4e-42 140.4 In-house 44-288 (297) alignment 
Range on Protein: 630-872
Range on HMM: 44-288/297.0
PAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRN-AFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQEY-P
  . |.|.....|..||| ..... .  || |..| ..|.|||||| ..  |  |. |.|||| || .|| |||.|| .  .  ||.| .|.| . .   
epstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqck

QYWPDHGATKYGHIGVSVLSKQEKGDVICTKLKVTRKKVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQcGNAPVLVQCSNGVGRSGTFC
.||||.|.  |.   | ..|.    |    .    .    ..|. |  .|..|||.. .|  | |.|..    . | .    .|..| ||.|.||.|...
rywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG.rscpivvhcsdGaGrtGvyi

AISSVLERL-KTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQII
.|  ||.|| |  . ||.   .. .| . || |..  |. |... .
lidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltav
0049772 (Phosphotyrosine protein) phosphatases II 340-584 1.6e-42 141.7 In-house 36-281 (314) alignment 
Range on Protein: 340-584
Range on HMM: 36-281/314.0
FPWEAARKPANKNKNRYANIVAYDhSRVVLERVNGDeDSDYINASFIHGYdgtpRSFIASQGPLPPAFEGF----------WRMV--WEQNSQSIVM---
. . .|....|..|||| .|. .| .||.| ..... .|||||||...|.    ..|||.||||.  .. |          ||||  ...|.  |||   
ltilvadlflnrdknryldilpad.nrvilpglpvs.gsdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrd

------------------LTNLVELGktkcHKYWPDKIETYGgvtvtlhqseifadyE-------IrtfilskakrsgSRMVRQFHFTVWPDKGVPqYAT
                  |..| ..|      ...  .|..                |                    .|.. ... . .|| ..|    
evladelsrLdaAlgKtpllildgng....neptaadlellk...............eelydpelf............erlgikylripvpDgsap.lle

AVLAFRRKVRALnpRDAGPVIVHCSAGVERTGTYIVIDAMLEQAKksrtVDIRNYLIALRKDRP-----HMVQTKEQYSFIHSAVLEALT
 ...| . ....  .. |||.|||.||. ||||..|.. .. . .    |...  |  .|. ||     ..... ||| ||. |.||.| 
dfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefilealleylk
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 617-875 4.1e-42 139.0 In-house 11-258 (267) alignment 
Range on Protein: 617-875
Range on HMM: 11-258/267.0
EFQRLNSVTSREIPaEEKSVGEEpqNLHKNRFSDIIALNSCRVMLHNEHADeesdYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVML
||. .. ... .     .|..|.  |  .||. | .  .  ||.| ..  .    |||| ...... .||||.|| ||  |. ||. ...|... .||.|
efelikkisdtsst.isqsiaek..nqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivll

NNLHEldQEYPQYWPDH--GATKYGHIGVSVLSKQEKGDVICTKLKVTRKKvrRKTQEVCHLHHVSWPDK--CIPELAcSVLDLLdeaQTSQQQCGNAPV
 .  .  .. ...|| .   | ||  . |    ..|. |     |..  |.    ...|   ..  |  .    | |   .. .|      | . || |.
tkvft..dnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfkn..esahnvtlyyykkwnintnnkpylk.plfgil...aknqlengnrPl

LVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKY
.|.||.||||||||  | | |||.|||.| |.|. ...||   .| |..  .|....... .|
vvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
subfamily_PTPN1_pd Subfamily PTPN1 633-872 4.3e-42 138.8 In-house 23-267 (290) alignment 
Range on Protein: 633-872
Range on HMM: 23-267/290.0
EKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHAdeesDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQE-YPQYWP
. .. ..|.|  .||. |.   . .|..|....     ||||| ...... .  .| || || .||. ||.|| . .  ..||||.. | .|    ||||
ptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywP

DHG---ATKYG--HIGVSVLSKQEKGDVICTKLKVTRKKVrRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQC-GNAPVLVQCSNGVGRSGT
 .    . ..   .. | ..|...|   .  .|... .|  ..|.|. | |...|||  .||   . |..| . . |        |... || |.|||||
qgeeekellledtklkvkliseerksyytvrllelenlkt.qetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGt

FCAISSVLERLKTEQ---VIDVFQVIKRIRVNLPGAVESPTQYLFCYQII
|| . ..| ... ..    .|. .|.  .|    | .  . |  | |. |
fclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylai
0046846 (Phosphotyrosine protein) phosphatases II 372-581 6.7e-42 138.5 In-house 6-171 (176) alignment 
Range on Protein: 372-581
Range on HMM: 6-171/176.0
VNGDEDSDYINASFIHGYDgtprsFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDkIETYGGvtvtlhqseifadyeirtfils
   |.|.|||||..| |.      .|| |||||  .. |..|..|.. . .|.||..||||. ||. |||. .|..|                       
lgldldldyinanlilgsr.....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe.leklgi......................

kakrsgsrmvrQFHFTVWPDKGVPQYaTAVLAFRRKVRALNPRDaGPVIVHCSAGVERTGTYIVIDAMLEqakkSRTVDIRNYLIALRKDRP-HMVQTKE
           |.... ||| |||.. ...| . . .|    .. |||.||||||. ||||..... .      .. ... . |  .|. || ..||| |
...........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpe

QYSFIHSAVLE
|| |.. ..|.
Qyrflyefell
0036282 (Phosphotyrosine protein) phosphatases II 670-870 6e-41 135.4 In-house 2-164 (174) alignment 
Range on Protein: 670-870
Range on HMM: 2-164/174.0
SDYINAVFLHAHRGRNAFIATQHPLLetvedFWRMVTDYDIGTIVMLNNLHELD-QEYPQYWPDhgatkyghigvsvlskqekgdvictklkvtrkKVRR
|||||| .|. ..  . .||.|.||      ||.|. ...| |.|||....||.    ..|||.                                .   
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lred

KTQEVCHLHHVSWPDKCIPELACsVLDLLDEAQTSQQQCGNAPVLVQCSNGVGRSGTFCAISSVLERLKtEQVIDVFQVIKRIRVNLPGAVESPTQYLFC
 .......... ||| . |.|.  .|........ ...... |||| || ||||.||..|.  .| .|. | ..|........|   ||.|..| || |.
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfl

YQ
|.
yy
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 631-872 1.1e-40 134.3 In-house 34-232 (392) alignment 
Range on Protein: 631-872
Range on HMM: 34-232/392.0
AEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDqeypqyw
. ...|.... ||.|||. .|. ..| ||.|       .|||.|| ....    .|.||.| |   ...|||||| . .. ||.|...|.| |       
iypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.......

pdhgatkyghigvsvlskqekgdvictklkvtrkkVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQCGnAPVLVQCSNGVGRSGTFCAIS
                                      ... |.  | . |||| .|. ..|.| .. | ..   |    |....|| ||||.|   .| 
...................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqyt.hpliihcsagvgrtgvvisid

SVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQII
||. . |. ...|||...  || . |  |..  || | |  .
svvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygav
subfamily_PTPN14_pd Subfamily PTPN14 622-877 1.2e-40 134.4 In-house 30-297 (300) alignment 
Range on Protein: 622-877
Range on HMM: 30-297/300.0
NSVTSREIpAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADeESDYINAVFLHAHRG--RNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNL
. .. ..    . |... |.| .|||| |..  . .|| |   . . ...||||  ...  |  .  .|..| ||  ||.|||.|| . ..  |||| . 
eripkkre.dallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmltee

HELDQE-YPQYWPDH----GATKYGHIGVSVLSKQEKGDVICTKLKVTRKKvRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQ--------Q
.|  .|   .|.|..       ..|.  |.   ... . || |.||.      .. ..| || .. |||. .||   . |. |.| |  ..        .
eedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlp.skeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnsevesk

CGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFD
  . |||| ||.||||.|       ... |.....||. .|..|.|      |.. .|| | |... ||..
eskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
0043147 (Phosphotyrosine protein) phosphatases II 374-576 2.3e-40 133.5 In-house 1-154 (172) alignment 
Range on Protein: 374-576
Range on HMM: 1-154/172.0
GDEDSDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLvelgktkchkywpdkietyggvtvtlhqseifadyeirtfilSKA
|||.|||||||....|  ..| ||| ||||.  .. ||||..|.. . ||.||.|                                           . 
gdegsdyinasyldlyyipdr.fiatqgplrntladfwrmlkelgithivnltel..........................................lyd

KRSGSRMVRQFHFTVWPDKGVPqYATAVLAFRRKVRA-LNPRDAGPVIVHCSAGVERTGTYIVIDAMLeqakksRTVDIRNYLIALRKDRPHMVQTKEQY
.   .|.. |.... ||| |||  .  .| | . ..  |. .. |||.||||||| |||| .... ||      . ... . .  .|. ||..||...||
pellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqy

SFIH
 |..
rfly
0041856 (Phosphotyrosine protein) phosphatases II 642-875 2.4e-40 133.4 In-house 1-170 (182) alignment 
Range on Protein: 642-875
Range on HMM: 1-170/182.0
NLHKNRFSDIIALNSCRvmlhnehadeESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNnlheldqeYPQYWPDHGatkyghi
||.|||.|||.  .  |           .||||| ..   .  . |||||.|||.||.||.||. ...|.|||.|.         ..|||..        
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt........eelywpell.......

gvsvlskqekgdvictklkvtrkkvrrkTQEVCHLHHVSWPDKCIPElACSVLDLLDEAQTsqqqcGNAPVLVQCSNGVGRSGTFCAISSVLERlkteQv
                            ...........||| ..|.   ..||...|..       . |||| || ||||.||..|.  ....    . 
............................erlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.

IDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKY
.......| .|   ||.|..| || |.....  .
vsleeavklvrsrRpgmvitpnqyfflqlallel
0049772 (Phosphotyrosine protein) phosphatases II 602-883 1.5e-39 131.9 In-house 6-287 (314) alignment 
Range on Protein: 602-883
Range on HMM: 6-287/314.0
LASVNRKFQMTGYALEFQRLNSVTSREIPAEEKSVGEEPQNLHKNRFSDIIALNsCRVMLHNEHADEeSDYINAVFLHAHrgrNAFIATQHPLLETVEDF
|||...  ..  .  ....||... . .|.    |.  . | .|||. ||.  . .||.|.... .  |||||| ... .   ..|||||.|| .||.||
lasfsellihddllklllvlnrrslsvlpeltilvadlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdf

----------WRMV--TDYDIGTIVM---------------------LNNLHEL-DQEYPQYWPDHGatkyghigvsvlskqekgdvictklK-------
          ||||   |... .|||                     |..| .. ..  .......                          .       
reepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgngneptaadlellk.........................eelydpel

VtrkkvrrkTQEVCHLHHVSWPDKCIPeLACSVLDLLDEAQTSqqqCGNAPVLVQCSNGVGRSGTFCAISSVLERLKteqViDVFQVIKRIRVNLP----
.        .... ..... .|| . | |   ....|.  ..      . |||| |. |.||.|||...  .. .|.   | .. ......|   |    
f........erlgikylripvpDgsap.lledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllg...v.sleealedvrlkRpinpn

-GAVESPTQYLFCYQIIQKYFDSFSDYA
 |..|.. ||.|.......|.. . .. 
pgfieqleqyefilealleylkflkkfy
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 350-581 5.6e-39 128.7 In-house 33-257 (267) alignment 
Range on Protein: 350-581
Range on HMM: 33-257/267.0
NKNKNRYANIVAYDHSRVVLERVNGDedsdYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNlveLGKTKCHKYWPDK---IET
|...||. . . ||..||.|   . .    |||||...||  | . ||. |.||  .   |. .. .|.   ||.||.    .. . ...|| |    . 
nqernrlddnlpyddtrvilrtkeee....yinasyvegyk.tknafivtqdplkntitdfltvihdqkvpvivlltk...vftdnirlfwPPkmgqakk

YGGVTVTLHQSEIFADYEIRTFILsKAKRSGSRMVRQFHFTVWPDKG-VPQYATAVLAFRRKVRALNprDAGPVIVHCSAGVERTGTYIVIDAMLEQAKK
|  .||     .   ||.| |. | | |   .. |  ...  |  .     |   ...   | .  |     |..|.||.|| |.||..|||..||.||.
yqdltvehslekeendyqiitlel.kfknesahnvtlyyykkwnintnnkpylkplfgilaknqlen..gnrPlvvacsdGvGrsGtflvidsqlerakt

SRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
  ..|| ..|  .|. |. .|.|||.| .||  . |
egvsdifdflrkirsqriglvdtkeryiyihellae
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 349-581 7.9e-39 128.1 In-house 54-287 (305) alignment 
Range on Protein: 349-581
Range on HMM: 54-287/305.0
ANKNKNRYANIVAYDHSRVVLERVNgdeDSDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP----DKI
 .. ||||... . |.| | |.. .    |||| | ..       . ||..||||  . . || || ... . |||| . ||||| || .|||    .| 
iaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekl

ETYGGVTVTLH--QSEIFADYEIRTFILSKAKRSGSRM-VRQFHFTVWPDKGVPQYATAVLAFRRKVRAlnprDAGPVIVHCSAGVERTGTYIVIDAMLE
|  .|. |        .  | ||.  .|  .   . .| ||....| |||.|||    . | .   .|        |..||||||. |||| . |. .||
elksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairg....skvpivvhcsagigrtgtivaieyile

QAKKSR-TVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
.  . .    . . . ||| .| . .|.  || |||  .|.
kiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln
0049260 (Phosphotyrosine protein) phosphatases II 393-576 8e-39 128.1 In-house 8-143 (152) alignment 
Range on Protein: 393-576
Range on HMM: 8-143/152.0
PRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWpdkietyggvtvtlhqseifadyeirtfilskakrsgsrmvrQFHFTVWPDK
|. ||| |||.|  .. ||||..|.. . |||||.|.|||| ||..|.                                          |.... ||| 
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................................qylhlpwpDh

GVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVERTGTYIVIDAMLeqakksRTVDIRNYLIALRKDRPHMVQTKEQYSFIH
|||. .  .| . . .. |. .. |||.||||||| ||||..... ||      . |.. ...  .|. ||..|....|. |..
gvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 641-872 8.3e-39 128.2 In-house 2-235 (237) alignment 
Range on Protein: 641-872
Range on HMM: 2-235/237.0
QNLHKNRFSDIIALNSCRVMLHNEHADeeSDYINAVFLHAHRGR-NAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQE-YPQYWPDHG-ATK
.|  |||...|.| . .||.|.   ..  |||||| .|.   |  . .||.| ||  . .|||.|| .     ||||  | | ...   .|||.    . 
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGHIGVSVLSKQEKGDVICTKLKVTRKKVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQ-TSQQQCGNAPVLVQCSNGVGRSGTFCAISSVLERL
|| . ||.  |.|  |     | ....   .. . .   .  ||||. .|. ....| .  .    |.     .| .. || ||||.| |  | ..| . 
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

KTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQII
| ..|.|... .. |  . |  ...  ||.| .| |
kekkvvdiynyvysieedrpyiiqtkdqyvfihqti
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 596-877 1.2e-38 127.4 In-house 11-284 (290) alignment 
Range on Protein: 596-877
Range on HMM: 11-284/290.0
NQAMQKLASVNRKFQMTGYALEFqrLNSVTSR-EIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEhadEESDYINAVFLHAHrgRNAFIATQHPL
 .|..|.||   | .. ..| |.  |. .         |... ..  ...|||. |..  .  ||.|..     . ||. | ...    .  || || .|
teafekfasdvvkknvdelakey..leklkpylpvqylerkifdkntefkknrykdvvcndktrvilkdG...ydGdyvhanyvkGl..kamfiltqGal

LETVEDFWRMVTDYDIGTIVMLNNLHELDQ-EYPQYWPDHG--ATKYGHIGVSVLSKQEKGDVICTKLKVTRKKVRRKTQEVCHLHHVSWPDKCIPELAC
 .|| |.|||| . .. .|||| .| |  .    ||.|..   .  .|.| |    ...| . |  |.   |.|   |   . ||. .|||||...  . 
kdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstl

SVLDLLDEAQTSqqqCGnaPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFD
..| .|   ..     |  || | || |.||.||| ||   |. |   . .|. .... .|    ..|.  .|||   .|. ..  
allrtlrilrka...sG..pvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGk
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 642-869 1.5e-38 127.3 In-house 8-234 (239) alignment 
Range on Protein: 642-869
Range on HMM: 8-234/239.0
NLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGR-NAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELD-QEYPQYWPDHgATKYG
|  |||...|.. .  ||.| .   |  |||||| .|. . |  .|.||||  .  .  |||||. .     ||||  | |   ..  |||||  ..|| 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.tskyc

HIGVSVLSKQEKGDVICTKLkVTRKKVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDeAQTSQQQCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTE
 . |..   .   | |   . |  .  . . . | . |   |||| .|. | .|| |     | .   |  | ...|| ||||.|.|  | ..| . | .
nlrvtlrktevfadyiirtf.vmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrr.kitkdslpgarpwvihcsagvgrtgaflvidamlrqakkq

QVIDVFQVIKRIRVNLPGAVESPTQYLFCY
. .|.|. .| || . |  |..  ||.| .
ktvdifnyvkairedrphmvqtseqyvfih
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 642-869 1.5e-38 127.3 In-house 7-233 (239) alignment 
Range on Protein: 642-869
Range on HMM: 7-233/239.0
NLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGR-NAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELD-QEYPQYWPDHgATKYG
|  |||...|.. .  ||.| .   |  |||||| .|. . |  .|.||||  .  .  |||||. .     ||||  | |   ..  |||||  ..|| 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.tskyc

HIGVSVLSKQEKGDVICTKLkVTRKKVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDeAQTSQQQCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTE
 . |..   .   | |   . |  .  . . . | . |   |||| .|. | .|| |     | .   |  | ...|| ||||.|.|  | ..| . | .
nlrvtlrktevfadyiirtf.vmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrr.kitkdslpgarpwvihcsagvgrtgaflvidamlrqakkq

QVIDVFQVIKRIRVNLPGAVESPTQYLFCY
. .|.|. .| || . |  |..  ||.| .
ktvdifnyvkairedrphmvqtseqyvfih
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 325-582 1.6e-37 123.9 In-house 22-286 (305) alignment 
Range on Protein: 325-582
Range on HMM: 22-286/305.0
IRLENEY---KKFNNGQQFpwEAARKPANKNKNRYANIVAYDHSRVVLervNGDEDSDYINASFIHGyDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQS
. | .|.   |.||. ...  .| ..  ...|||| ..   |. || |   .|    .|| | ..      |. || .| ||  .   || | .... ..
aglraefvamkrfndfekm..kafkeaqeagknrykdvgcldnnrvkl...egpwpheyihanyvst.ptnpkrfictqaplektcadfwymclqdkvea

IVMLTNLVELGKTKCHKYWPDKI-------ETYGGVTVTLHQSEIF-----ADYEI-RTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKV
| || ||.| |  ||..|.. |        |    ..| .  |. .     |. .. .| .. .   . .| | ..|.  |||.|||   .|.| .  | 
ifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelleka

RALNprdaGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRN-YLIALRKDRPHMVQTKEQYSFIHSAVLEA
|..     ||..||||||. |||. .... .|.|    . ..  .  |  .|..|   .|| .|| |.|  .|. 
rpsk....gpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilny
0046846 (Phosphotyrosine protein) phosphatases II 664-877 1.9e-37 124.0 In-house 6-174 (176) alignment 
Range on Protein: 664-877
Range on HMM: 6-174/176.0
EHADEESDYINAVFLHAHRgrnaFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQEY-PQYWPDhgATKYGHigvsvlskqekgdvictklkvt
 . |. .||||| ..  .|    .||||.|| .|..||..|. ...|...|.|....||..   |.|||.   .|.|.                      
lgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi......................

rkkvrrktqevcHLHHVSWPDKCIPELaCSVLDLLDEAQTSQQQcgNAPVLVQCSNGVGRSGTFCAISsvleRLKTEQVIDVFQVIKRIRVNLP-GAVES
            . .|. ||| ..|.|   .|.||.. .. ...  . |||| || |.||.||..|.      |..|. ..|.......|   | |||..
............qylhlpwpDhgvpdl.elllellefirealke..ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqt

PTQYLFCYQIIQKYFD
| || |.|. ......
peQyrflyefellllk
0044763 (Phosphotyrosine protein) phosphatases II 362-580 3.3e-37 123.2 In-house 2-168 (178) alignment 
Range on Protein: 362-580
Range on HMM: 2-168/178.0
YDHSRVVLERVNGDEDSDYINASFIHGYdgtprSFIASQGPlppafEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKIEtyggvtvtlhqseifa
.|..||.|. . | | |||||||.| ..      ...|..|     . ......|.. ..||.||. .|||. ||..|||.. .                
ldrtrvllsnleglersdyinaseilpg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

dyeirtfilskakrsgsrmvRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVERTGTYIVIDAMLEQakksrTVDIRNYLIALRKD
                     |.... .|| |||.    .|.| . .... ... |||.||||||| |.|| .... |...      ... . .  .|. 
....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrer

RPhMVQTKEQYSFIHSAVL
|| .|.. .|. ...   |
Rp.ivpnpgqlrqLyefel
0043147 (Phosphotyrosine protein) phosphatases II 667-870 4.3e-37 122.8 In-house 2-155 (172) alignment 
Range on Protein: 667-870
Range on HMM: 2-155/172.0
DEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLheldqeypqywpdhgatkyghigvsvlskqekgdvictklkvtRKKV
|| |||||| .|. ..  . ||||| || .|..|||||. ...|..||.|..|                                            .  
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydp

RRKTQEVCHLHHVSWPDKCIPeLACSVLDLLDEAQTSQQQCGNAPVLVQCSNGVGRSGTFCAISSVLerlkteQVIDVFQVIKRIRVNLPGAVESPTQYL
   ...........||| . | |.  .|..|.  .. .... . |||| || ||||.||..|.  .|      . ........ .|   ||||..| || 
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyr

FCYQ
|.|.
flyy
subfamily_CG42327_pd Subfamily CG42327 348-509 9.8e-37 121.3 In-house 26-191 (319) alignment 
Range on Protein: 348-509
Range on HMM: 26-191/319.0
PANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK----
.. |.|.|..|.|   ..||||.|.  |. . |..||.. ||| .| |.||.| .|  .   |||.||||.|. || ||.| |||  .| .|.| |    
vtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketld

-IETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFtVWPDKGVPQYATAVLAFRRKVR
  ..|| . ||| . |.   | | |..| . ... || .  . .  |.. .||   .|..|   .||
ntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevr
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 627-878 1.3e-36 120.9 In-house 24-279 (287) alignment 
Range on Protein: 627-878
Range on HMM: 24-279/287.0
REIPAEEKSvGEEPQNLHKNRFSDIIALNSCRVMLHNEhADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVML-NNLHELDQE
.  .|  |.  ||  . .|||..|.. ..  ||.| .| ..  |||||| .. ...  .||||.| |.  || ||||.| .    .....  .. |  ..
esstatfka.aeelaavkknryadvlPiddtrvllsae.gelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlk

YPQYWPD-HGATKYGHIGVSVLSKQEKGDVICTK-LKVTRKKvRRKTQEVCHLHHVSWPDKCIPEL----ACSVLDLLDEAQTSQQQCGNAPVLVQCSNG
  .|||. .   . |   | .|... |    ... |..   .  |... |  |. .||||| ..      .  |||  .  . ...  .  |..| .. |
cykywPerevPmrvGGysvvlldydikePeygvralrlidle.trearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvG

VGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFDS
.||||.. |.  ...||.    .|| .|. |.|    . | .. |. . |. .  |. .
iGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyykt
subfamily_ptpA1_pd Subfamily ptpA1 347-541 8.3e-36 118.6 In-house 44-254 (418) alignment 
Range on Protein: 347-541
Range on HMM: 44-254/418.0
KPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGydGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKIET
|  | .||||.||.  .|.|| |....  | |||||| .| |    |. ||..||||| .   |||||||.  . ||||.   |  . || .|||..|  
kkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg..aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigg

-----YGGV-----TVTLHQSEIFAD--YEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAF-----RRKVRALNPRD-AGPVIVHCSAGVE
     ||       | ..   |.  |   || |  .  .    .| . |...  |||. .|...  .  .      |. . .   |   |.|||||||| 
eqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvg

RTGTYIVIDAMLE
||||.     |..
rtgtfctavimmk
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 327-587 1.9e-35 117.3 In-house 21-275 (288) alignment 
Range on Protein: 327-587
Range on HMM: 21-275/288.0
LENEYKKFNNGQQFPwEAARKPANKNKNRYANIVAYDHSRVVLErvngdEDSDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLT
|. ||.   |. .    .    ||  ..|| |.   | .|| |.     .|.|.  |. .      .| .| .| ||  . | .|.|. |.. . ||||.
lkkeyrdspneasid.iidsfianptrdryenlprcditrvkls.....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlc

NLVELGKTKCHKYWPDKIETY---GGVTVTLHQSEIFADYEIRTFILSKAKRSGSRM-VRQFHFTVWPDKGVPQYATAVLAFRRKVRALNprdaGPVIVH
.|.|.|| |  .|.| |.      | .     ..    |  ..  .|   |    .. |.. |.  |.|.|||.   . | .   ...|.     |..||
ellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslq....kPivvh

CSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGN
.|||| |||| |.|  .||... .  . ||. |  ||..| . .||. || ..|  ||| |    
ssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelllkk
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 346-581 1.2e-34 114.3 In-house 33-267 (281) alignment 
Range on Protein: 346-581
Range on HMM: 33-267/281.0
RKPANKNKNRYANIVAYDHSRVVLER-VNGDEDSDYINASFIHGyDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKI
 .| |..||||.|| . | ||| |.  .   . .||| | .|.      | .| .|||   .   ||||.|..|. .|||| ...|  . || .|.| . 
nqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirs.pflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprna

ET---YGGVTVTLHQSEIfaDYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRAlnpRDAgPVIVHCSAGVERTGTYIVIDAMLE
     .  ..|.  .| .  .  . |  |  .    .|.. .. .  |||  ||. .  .|   ||.||   | . | ..|||||| |.|| . ..  |.
hcclqfdklsvsyedstv..nkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkira...rst.ppvihcsagvgrsgtlmaveialq

QAKKSRTV-DIRNYLIALRK-DRPHMVQTKEQYSFIHSAVLE
  .   |. ||.. .  ||   |   ||| .|| .|   .|.
sihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 328-592 2.6e-34 113.2 In-house 30-298 (310) alignment 
Range on Protein: 328-592
Range on HMM: 30-298/310.0
ENEYKKFNNGQQ--FPWEAARKpaNKNKNRYANIVAYDHSRVVLErVNGDEDSDYINASFIHGyDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVML
 ..|.|..  |.  . .|| .|  .  ||||...|  | ||| |. ..     ||| | ...  .    .|| |||||  .   ||||.... ..||..|
vkqyrkldakqdssltyeaykk..ymhknrysdvvcldtsrvklk.idksryedyihanyvkt.nylrstficsqgplqhtiidfwrmifqeraesilll

TNLVELGKTKCHKYWPD--KIETYGGVTVTlHQSEIFADYEIR----TFILSKAK------RSGSRMVRQFHFTVWPDKGVPQYATAVLAFrrkvRALNP
 . .| |. ||  |||     |||| . ||   ||   ..||     ||.  .              |   ..  |||.|||.     .      | |  
ckvgeegrpkcvgywpslgvtetygcirvt.nlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpq....rllaq

RDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLeALTCGNTEIQS
   ||..||||||..|... . ..  ......   ||. .    |.|.|   .||. || .|.   . ... |.||.  
vrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvri.ifargetevae
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 640-876 5e-34 112.7 In-house 39-277 (307) alignment 
Range on Protein: 640-876
Range on HMM: 39-277/307.0
PQNLHKNRFSDIIALNSCRVMLHNEHAdeESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ-EYPQYWPDHGATK-
  | .|||..|. . . .|.... . .   |||| | .|      . ||..| || .|. .|| |. . .. ...|| .. || .    ||||     | 
santdknryqdvkcqdkgrivvkfdgl..asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqkl

-YGH----IGVSVLS-KQEKGDVICTKLKVTRKKVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQqqcgnAPVLVQCSNGVGRSGTFCAISS
 .|.    | |. |  |.   |  . ..   . .  .|.. . ||    |||. .|..  . ..||.  .  .      ||.| || |||||||  ||| 
vfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydt.....npvvvhcsaGvGrsGtivaisl

VLERL-KTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYF
| ... . .   |. .... .| . . |...  |||. .... .||
vqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
0051082 (Phosphotyrosine protein) phosphatases II 377-580 6.4e-34 112.1 In-house 2-150 (151) alignment 
Range on Protein: 377-580
Range on HMM: 2-150/151.0
DSDYINASFIHGYdgtprsFIASQGPLPpafeGFWRMVWEQNSQSIVMLTNLVELGktKCHKYWPDKIetyggvtvtlhqseifadyeirtfilskakrs
 |||||.|.. |.      ...|.|||.     |.....|.. ..||.|....| |  .|..|.|.                                  
lsdyinfsyvtgg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg................................

gsRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRAlnpRDAGPVIVHCSAGVERTGTYIVIDAMLEQakksrtVDIRNYLIALRKDRPHMVQTKEQYSFIH
  . |...... ||| |.|..  |||.| .....    . |||.||||||. |||| .... ||..      |..   |  .|. ||..||...|. |..
..ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfql

SAVL
 |.|
fall
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 350-587 6.8e-34 112.0 In-house 43-280 (312) alignment 
Range on Protein: 350-587
Range on HMM: 43-280/312.0
NKNKNRYANIVAYDHSRVVLervNGDEDsDYINASFIHGYdGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKIE----
 |. ||| ||  .|  |  |    |||.  || | |..     |  |...||||  .   ||...    | ||..|. .|| |  || ||  | .     
fkdlnrypniqcwdrgrftl...agden.fyihanfvkic.tkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdl

-TYGGVTVTLHQSEIFADY--EIRTF---ILSKAKRSGSRmVRQFHFTVWPDKGVPQYATAVLafrRKVRALNpRDAGPVIVHCSAGVERTGTYIVIDAM
  .   |    . ||       |      .. ||    |. . .. .. |||.|.|.   . |   | . |.. .|  ||| |||||| |||| ..|..|
edhrvyteycteieiggkskdkithrvlkvvvkatgqesk.lnhyqwaswpdhgmpdscdtal...rllsavk.kdkkpviahcsagvgrtgtlaliesm

LEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGN
.   .. |  .... .. |||||   |..  || .   .||| | .  
iaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskg
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 640-876 9.6e-34 111.7 In-house 41-271 (288) alignment 
Range on Protein: 640-876
Range on HMM: 41-271/288.0
PQNLHKNRFSDIIALNSCRVMLHnehaDEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQEY-PQYWPDHG--AT
 .|  ..|. ..   . .|| |.    |.   ||.|  . ... .. .| .| ||  |.| .|.|. . |.  ||||..| |. .|   .|.| .   ..
ianptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGeka

KYGHIgvSVLSKQEKgDVICTKLKVTRKKVRRKTQE---VCHLHHVSWPDKCIPELACSVLDLLDEAqtsqqQCGNAPVLVQCSNGVGRSGTFCAISSVL
..|..      |... . |   .||.  .. ....|   | .||   |.|...||   | | ||.       .  . |..|..|.||||.||.  |  .|
rigrl..ctvvkkkr.adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililial

ERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYF
| |. .  . . ..... | .   |...  |||. .... ...
eslrlddflgirsllaklreerfkaiqtemqylyvhrcvleel
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 335-508 1.8e-33 110.7 In-house 18-193 (297) alignment 
Range on Protein: 335-508
Range on HMM: 18-193/297.0
NNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNgdEDSDYINASFIHGY-DGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGK
.. .   . .|....   |||| .|.|.| .|| | ||    ..||||| ..    . ..  .| .||||  . . ||..|.||. . |||...| | |.
deargesfssakrnsslrknryrdilatddtrvkllrvi..terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGr

TKCHKYWPDKIET--YGGVTVTLHQSEIFADYEIR-TFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKV
 ||  |||.  .     |  |  . |.   ...      |    || ||.||   |  |||.|||     .  |. .|
dkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqv
PTPc_DSPc_SM00012 481-581 5e-33 108.8 In-house 2-105 (105) alignment 
Range on Protein: 481-581
Range on HMM: 2-105/105.0
VRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDA--GPVIVHCSAGVERTGTYIVIDAMLEQAKKS-RTVDIRNYLIALRKDRPHMVQTKEQYSFIHS
|...|.| |||.|||......| . |.|.  .   .  .||.||||||| ||||....| .|.| .|. ..||| ... .||| ||.||||.|||.|.. 
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AVLE
|.||
alle
0049260 (Phosphotyrosine protein) phosphatases II 681-870 5.6e-33 109.1 In-house 5-144 (152) alignment 
Range on Protein: 681-870
Range on HMM: 5-144/152.0
HRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQE-YPQYWpdhgatkyghigvsvlskqekgdvictklkvtrkkvrrktqevcHLHHV
..  ..|||||.|. .|..|||||. ...|.|||||..|.||. .  .||.                                            . .|.
yampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................qylhl

SWPDKCIPELACSVLDLLDEAQTSqQQCGNAPVLVQCSNGVGRSGTFCAISSVLerlkteQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQ
 ||| . |.|.  .|.||.  .   ..  . |||| || ||||.||..|.  .|      . ..........|   ||||..| |. |.|.
pwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 627-873 3.1e-32 106.6 In-house 18-292 (297) alignment 
Range on Protein: 627-873
Range on HMM: 18-292/297.0
REIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNehADEESDYINAVFLH--AHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ
.|  .|. |.   .  |.|||. ||.| .. || | .  .  |.||||| ..          .| .| || .||.|||..|.. |...|||. .| |  .
deargesfssakrnsslrknryrdilatddtrvkllr..viterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGr

E--YPqYWPD--HGATKYGHIGVSVLSKQ--EKGDVICTKLKVTRKkvrRKTQEVCHLHHVSWPDKCIP----EL------ACS-------VLDLLD---
.  .| |||.   .  | |.. |  ||.   |   || |.|..  .    ... | |  ..||||. .|    .|       ||       .| |..   
dkcap.ywpsvvqerlkagdvvveflsstsdefdrviltelqliyr...sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemft

-----EAQTSQ-QQCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQ
     . .. . ..  ||..|| || ||||||       .|..|. ... ||  ... .| . .  |..  |. ..|... 
amvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 477-613 3.7e-32 106.2 In-house 87-224 (440) alignment 
Range on Protein: 477-613
Range on HMM: 87-224/440.0
GSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALN-PRDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFI
 || ..|.|.  |||||||..|  || . . |   .     ||..||||||. |||  |..|..| .||.|  .|| ... ..|..||.|||| |||.|.
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

HSAVLEALTCGNTEIQSETYNQAMQKLASVNRKFQMTG
| ||||.| ||.| |  .   . ....   | . . . 
heavlegllcgdtliledditerveqiqwpnphtdksp
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 348-583 1.8e-31 104.1 In-house 33-270 (285) alignment 
Range on Protein: 348-583
Range on HMM: 33-270/285.0
PANKNKNRYANIVAYDHSRVVLErvngDEDSDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKIE--
 || . ||||.. . . .||||.    . | ||| ||...       ..|..||||| ..  ||.|.....   ..||  |.| |  ||  |.|.|.   
eanpdlnryadvrcieetrvvlk....nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgev

-TYGGVTVTL--HQSEIFADYEIRTFILSKAKRSGSRMVRQFH--FTVWPDKGVPQYATAVLAFRRKVRALNPRDAgPVIVHCSAGVERTGTYIVIDAML
  .|   .||   . |  |   . .. . ... . |  .   |     |||.  |. |  .. . . |. .||..  |. ||||||| || |.. ||   
vkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkek.picvhcsagvgrtatfvgidyat

EQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
 .  .   ... . .  .|  | . ||.. |. |..  ..| .
irimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 638-877 1.8e-31 104.0 In-house 44-288 (305) alignment 
Range on Protein: 638-877
Range on HMM: 44-288/305.0
EEPQNLHKNRFSDIIALNSCRVMLHNEHAdeeSDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELD-QEYPQYWPDH--G
 | |. .|||. |.  |.  || |..       .|| | .. .    . || || || .|  ||| |  .  . .| || || |   .   .|.. .   
keaqeagknrykdvgcldnnrvklegpwp...heyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkd

ATKYGHIGVSVLSKQEKGDVI----CTKLKVTR-----KKVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQqqcgnAPVLVQCSNGVGRSGT
  ..   |  .  | |    .     .| |||.     .    |.. | | | . |||. .|    ..|.|| .|..|.      |. | || |.||.|.
vlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpsk.....gpivvhcsagigrtgs

FCAISSVLERLKTEQVID-VFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFD
   .  .|..| . |.|.   .....|| .   .... .|||| .|.| .|| 
vvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 681-871 1.9e-31 103.8 In-house 1-199 (199) alignment 
Range on Protein: 681-871
Range on HMM: 1-199/199.0
HRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ-EYPQYWP--DHGATKYGHIGVSVLSKQEKGDVICTKLKVTRKK-VRRKTQEVCHL
|.|.  .||||||| ||. |||.|| .   | |||.|.     . .|| |||  . |..||| . |.. .   | |   | | .| .      |.|. | 
hkgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishy

HHVSWPDKCIPELACSVLDLLDEAQTS--QQQCGNAPVLVQCSNGVGRSGTFCAISSVL---ERLKTeQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQI
   || .|  |..|  |  ..   . |   .|  .|||.|.||.| | .| | |.   .   |  ||  |.|.|.| ||.|    | . |  .| | ||.
qftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 683-871 7.3e-31 101.9 In-house 2-198 (198) alignment 
Range on Protein: 683-871
Range on HMM: 2-198/198.0
GRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ-EYPQYWP--DHGATKYGHIGVSVLSKQEKGDVICTKLKVTRKK-VRRKTQEVCHLHH
|.  .||||||| ||. |||.|| .   | |||.|.     . .|| |||  . |..||| . |.. .   | |   | | .| .      |.|. |   
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

VSWPDKCIPELACSVLDLLDEAQTS--QQQCGNAPVLVQCSNGVGRSGTFCAISSVL---ERLKTeQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQI
 || .|  |..|  |  ..   . |   .|  .|||.|.||.| | .| | |.   .   |  ||  |.|.|.| ||.|    | . |  .| | ||.
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfiyqv
PTPc_DSPc_SM00012 773-873 1.6e-29 97.6 In-house 2-104 (105) alignment 
Range on Protein: 773-873
Range on HMM: 2-104/105.0
VCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQCG-NAPVLVQCSNGVGRSGTFCAISSVLERLKTE-QVIDVFQVIKRIRVNLPGAVESPTQYLFCYQ
| |.|. .|||...|| . |.|.||.. ........ ..||.|.||.||||.|||.|.. .|..|..| . .|.||..|..|   ||.|.. .||||.|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

IIQ
...
all
0051082 (Phosphotyrosine protein) phosphatases II 670-872 5.9e-29 96.0 In-house 3-149 (151) alignment 
Range on Protein: 670-872
Range on HMM: 3-149/151.0
SDYINAVFLHAHrgrnaFIATQHPlletVEDFWRMVTDYDIGTIVMLNNLHELDqEYPQYWPDHGatkyghigvsvlskqekgdvictklkvtrkkvrrk
|||||. ..  .     ......|     .||.... ...| |||.|....| .  .|.|.|..|                                   
sdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg.ycpeylpelg...................................

tQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTsqqqCGNAPVLVQCSNGVGRSGTFCAISSVLERlkteqvIDVFQVIKRIRVNLPGAVESPTQYLFCY
  ||.|.. ..|||  .|..  .||..|....     ..| |||| || |.||.||..|.  .|..      ........ .|   ||.| ...|.||..
.ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfql

QII
. .
fal
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 640-871 5.9e-28 92.3 In-house 50-285 (310) alignment 
Range on Protein: 640-871
Range on HMM: 50-285/310.0
PQNLHKNRFSDIIALNSCRVMLHNEHADeESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQEY-PQYWPDHGATK-
 ...||||.||.. |...|| |. ...    ||| | ....   |..|| .| ||  |. |||||. .    .|..| .  |  .     |||  | |. 
kkymhknrysdvvcldtsrvklkidksr.yedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtet

YGHIGVSVLSKQEKGDVICT--------KLKVTRKKVRRKTQEVCHLHHVSWPDKCIPELACSVLdlldeAQTSQQQCGNAPVLVQCSNGVGRSGTFCAI
|| | |. ||.  .   ||         .. |  .    |   |  ..   |||. .|.  |  .      |    |    |..|.|| |..| .. .|.
ygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtv.....pqrllaqvrhgpcvvhcsagkdrlyvvval

SSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQI
   ...|.  . .|. .|.  .. .    .... |||.  ..
klkidkldrglkvdaeevktellksraiciqtelqyliidrv
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 350-602 6.1e-28 92.4 In-house 50-299 (301) alignment 
Range on Protein: 350-602
Range on HMM: 50-299/301.0
NKNKNRYANIvAYDHSRVVLERVNGDedSDYINASFIHGYdGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKIET---
.|.|.|| ..   . |  |   |.|      | | .|    | |. |||.||||. . | || |.   . . ||||.. ||  ..||..| | ||.    
pkdkhryptv.PckPstavevivdGk..rvPihanwipts.GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekld

YGGVTVTLHQSEIFADYEI--RTFIL-SKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRalnpRDAGPVIVHCSAGVERTGTYIVIDAMLEQA
 |  .......|   . .|  ||. .   ...  .| |  . .. |.|.|||.  . .  .   |.    .   |..||||||. |. ..|  . .  . 
igrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvk....ksekPivvhcsaGiGrsvafigteylarev

KKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCgNTEIQSETYNQAMQKL
.  .|... . |  ||..| . |||..|  ..    .  |   . ...  .|.. .. .
eadptieltealkhlrehrwngvqtnsqlywmtlGtvyrlik.eygfdmkiyeeqlamf
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 642-876 1.8e-27 90.8 In-house 55-289 (305) alignment 
Range on Protein: 642-876
Range on HMM: 55-289/305.0
NLHKNRFSDIIALNSCRVMLHNEHadeESDYINAVFLHAHR-GRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ-EYPQYWPDHGATKYG
.  |||..|. . .   | |..      |||| | .. .     . ||..| || .|...|| || .  .  |||| .  || .    ||||     |  
aitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

-HIG--VSVLSKQ----EKGDVICTKLKVTRKkvRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQqqcgnAPVLVQCSNGVGRSGTFCAISSV
 . |  |  .|         ..  | |..|      ..  | ||.   |||. .|    . |.||   . |.      |..|.|| |.||.||  ||  .
lksgivvenvsgskpmerdaeiqitllnltys..gdqkmsvrhlqwtewpdrgvppckltslellsairgsk.....vpivvhcsagigrtgtivaieyi

LERLKTE-QVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYF
||..  . ..  . ...| .| .   ....  |||| .... .||
lekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 625-874 2.8e-27 90.1 In-house 20-267 (281) alignment 
Range on Protein: 625-874
Range on HMM: 20-267/281.0
TSREIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEH-ADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELD
   . |..  .| ..| | .|||...| .|.  || |. .    . .||| | ....   .  .| || |  ||  |||||. . .  .|||| .. | .
lpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletn

QEY-PQYWPD--HGATKYGHIGVSVLSKQEKGDVICTKLKVTRKkvrRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSqqqcgNAPVLVQCSNGV
.|   .|.|   | . .. .. ||      .  .. |.|... .    .|. . |     |||  .|| .  .| .| . ..       .| ...|| ||
rekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsye...getrlithwlwkewpdwqvpessevmlkilrkirar.....stppvihcsagv

GRSGTFCAISSVLERLKTEQV-IDVFQVIKRIRVNLPG-AVESPTQYLFCYQIIQK
|||||. |.   |. ...     |. |.. ..||     .|..  ||.. ....  
grsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 642-876 3.5e-27 90.1 In-house 35-270 (285) alignment 
Range on Protein: 642-876
Range on HMM: 35-270/285.0
NLHKNRFSDIIALNSCRVMLHNEhadeESDYINAVFLHA-HRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQEY-PQYWPDHG--ATK
|   ||..|. ...  ||.|.|     . ||| | ...   . ....|.|| || ||. |||.|. .  |  ..||  | |   |    |.|..     |
npdlnryadvrcieetrvvlknh....drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvk

YGHIGVSVLSKQEKG--DVICTKLKVTrkKVRRKTQEVCHLHHV---SWPDKCIPELACSVLDLLDEAQTSqqQCGNAPVLVQCSNGVGRSGTFCAISSV
.|.  ...   .|.     |   | |.  .    . |  .. ||    |||.  || |  ...|    .    .  . |. |.|| ||||. ||  |   
fgkyeitlteckeeaiagtilnaltvi..ntedasseplymnhvqvpwwpdqlapedarpmielykwvkkv..npkekpicvhcsagvgrtatfvgidya

LERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYF
  |.  .  |....... .|     ||.|  |.|| | .. .||
tirimenpniemldivremramrfqavqshmqflflyvvlmeyf
0044763 (Phosphotyrosine protein) phosphatases II 656-876 4.4e-27 90.3 In-house 4-171 (178) alignment 
Range on Protein: 656-876
Range on HMM: 4-171/178.0
SCRVMLHNEHADEESDYINAVFLHAHrgrnaFIATQHPLletvEDFWRMVTDYDIGTIVMLNNLHELD-QEYPQYWPDHGAtkyghigvsvlskqekgdv
 .|| |.|    | ||||||..   .     ......|     .|..... ...|..||.|..  ||  .....|||.                      
rtrvllsnleglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag...................

ictklkvtrkkvrrktqevCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQCGnAPVLVQCSNGVGRSGTFCAISSVLERlkteQViDVFQVIKRIRVN
                   .. .|. .|| . |.|   .|....  .. ....|  |||| || |||||||..|.  ....    .. .....|...|  
...................iqylhipipDhgvpdllehflefvefieealdekg.gpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrer

LPgAVESPTQYLFCYQIIQKYF
 | .|..| |. ..|.. ....
Rp.ivpnpgqlrqLyefelrll
subfamily_ptpA1_pd Subfamily ptpA1 630-836 7.5e-27 89.1 In-house 35-256 (418) alignment 
Range on Protein: 630-836
Range on HMM: 35-256/418.0
PAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRnAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHE-LDQEYPQ
   | | |.. .|  |||...|. .|  || |.. .  | |||||| ..     .  ||.|| || .|. |||||| .     ||||.   |    .  .
gpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk.qfictqgplpntiadfwrmvwenrcriivmlsresencrikcdr

YWPDH-GATKYGHI--GVSVLS--KQEKGDVICTKL-K-V---TRKKVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQC-----GNAPVL
|||.. |  ..     |  |.     |  .||     . .    |  .  .|... . ..  |||. ||. .  . .||      |.|       | |..
ywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpii

VQCSNGVGRSGTFCAISSVLERL
|.|| ||||.||||.   ....|
vhcsagvgrtgtfctavimmkkl
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 673-861 8.1e-26 85.5 In-house 78-266 (301) alignment 
Range on Protein: 673-861
Range on HMM: 78-266/301.0
INAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHE-LDQEYPQYWPDHGATK--YGHIGVSVLSKQE--KGDVICTKLKVTRKKVR
| | .. ..   . ||||| || .| |||| |.. ||. .|||| .  | | .   .| | . . |   |   . . .|.   . ...  .|.|.    .
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

RKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQqcgnaPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVES
 .|. | |  ...|.|. .|.    . ||.. .. |..     |..|.||.|.||| .| .   .  ...... |.. . .|..| .   .|  
fatrtvthyqysewtdrgvPkshaelfdlmelvkksek.....PivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqt
subfamily_egg_pd Subfamily egg 637-878 1.2e-25 84.8 In-house 35-272 (307) alignment 
Range on Protein: 637-878
Range on HMM: 35-272/307.0
GEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELdQEYPQYWPDHG--
  .  ||.| |   .   .|.|| |. ..     |.| |  .. .   | || .| || .||.||||||   ..  ||||.   |  .. . |||     
aasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes.erceyywpkaesd

ATK--YGHIGVSVLSKQEKGDVIctkLKVTRKKVRRKTQEVCHLHHVSWPDKCIPELAcSVLDLLDEAQTSqqqcgNAPVLVQCSNGVGRSGTFCAISSV
. .   | . .  |  ..| | .   ..||. |.    .|  .| |  .  .   ..  | | .|  ..         ||.||. .|| ...|. ||   
slvtvpGslrienlkvdskadpl...frvtklklvGgddeerflehwqgdvnnssdvy.splrvlrklrnl.....skpvvvqdilGvskaatlvaieia

LERLKTEQV--IDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFDS
|  |    .    | . .. .| . . .|||. .||| |...  .|  
llsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrd
0048076 (Phosphotyrosine protein) phosphatases II 447-580 1.4e-24 81.8 In-house 13-140 (145) alignment 
Range on Protein: 447-580
Range on HMM: 13-140/145.0
YGGVTvTLHQSEIFADYEIRT-FILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDaGPVIVHCSAGVERTGTYIVIDAMLEqakk
.|... | .. | ..|. |.| . |.  ..  .|.. |.... ||| |||. .  .|.| . .... ... |||.||||||| ||||..... ||.    
lgslp.taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll....

sRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVL
 . |.. . |  .|. ||..|.. .|. |.. ..|
.lgvsleealelvrsqrpgavpnpgqlrflyefel
subfamily_egg_pd Subfamily egg 339-580 7.2e-24 79.0 In-house 29-267 (307) alignment 
Range on Protein: 339-580
Range on HMM: 29-267/307.0
QFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELgkTKCHK
. . . | .  |..| |   .   | ||| ||  .|    |.| |  ..|       || .| ||  . . |||||.... | |||||  .|    .|. 
eislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkp.llnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..ercey

YWPDK----IET-YGGVTVTLHQSEIFADyeiRTFILSKAKRSGSRmVRQFHFTVWpdKGVPQYATAVLAFRRKVRALNpRDAGPVIVHCSAGVERTGTY
|||      . |  |.. ..  . .  ||     | ..| |  |.    . .   |  .|  .... |    | .| |  . . ||.|..  || ...| 
ywpkaesdslvtvpGslrienlkvdskad...plfrvtklklvGgd.deerflehw..qgdvnnssdvysplrvlrklr.nlskpvvvqdilGvskaatl

IVIDAMLEQAKKSRT--VDIRNYLIALRKDRPHMVQTKEQYSFIHSAVL
. |.  | .  .  .    ...    ||. |.  |..  .| |..  ||
vaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
0048179 (Phosphotyrosine protein) phosphatases II 460-577 2.9e-23 77.6 In-house 25-139 (144) alignment 
Range on Protein: 460-577
Range on HMM: 25-139/144.0
FADYEIRTFI---LSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDaGPVIVHCSAGVERTGTYIVIDAMLeqakkSRTVDIRNYLI
.... |.| |    .  . .  |.. |.... ||| |||.... .|.| . .... ... |||.||||||| ||||..... |.      . ... . | 
lkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk.....klglsleeala

ALRKDRPHMVQTKEQYSFIHS
 .|. ||..|.. .|. |.. 
lvrsrrpgavpnpgqlrfLle
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 394-576 1.9e-21 71.2 In-house 5-197 (199) alignment 
Range on Protein: 394-576
Range on HMM: 5-197/199.0
RSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK---IETYGGVTVTLHQSEIFADYEIRTFILSKAKR--SGSRMVRQFHFTV
| .||.| ||  ..  ||.||||  |  |||. .     ..    |||        || ..|| .     .|| | ..||..       .| . .. || 
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDKGVPQYAT---AVLAFRRKVRALNPRDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRT--VDIRNYLIALRKDRPHMVQTKEQYSFIH
| .|  |. |     |.| |   .  .     ||||||| |   || .. .|  .   ..|.|  ||. .    ||. |  .. . ..| ||.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 394-576 2e-21 71.1 In-house 4-196 (198) alignment 
Range on Protein: 394-576
Range on HMM: 4-196/198.0
RSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK---IETYGGVTVTLHQSEIFADYEIRTFILSKAKR--SGSRMVRQFHFTV
| .||.| ||  ..  ||.||||  |  |||. .     ..    |||        || ..|| .     .|| | ..||..       .| . .. || 
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDKGVPQYAT---AVLAFRRKVRALNPRDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRT--VDIRNYLIALRKDRPHMVQTKEQYSFIH
| .|  |. |     |.| |   .  .     ||||||| |   || .. .|  .   ..|.|  ||. .    ||. |  .. . ..| ||.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 352-455 3.1e-21 70.5 In-house 49-163 (350) alignment 
Range on Protein: 352-455
Range on HMM: 49-163/350.0
NKNRYANIVAYDHSRVVLER--------VNGDEDSDYINASFIHGY----DGTPRS-FIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHK
 |||| ||. |.|||| |..            . .|||||....      .  |   .|| |.||| ... |.... . . . |..||..|||.  ||..
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPDKieTYGGVTVTLH
||..   .| ..|| | 
YWqeg..sydditvkla
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 773-872 9.1e-21 68.7 In-house 91-190 (440) alignment 
Range on Protein: 773-872
Range on HMM: 91-190/440.0
VCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQII
. . |. .|||| .|..|  || .... . ||...||.|.||.|| |.||.|   |. |.|   |  . ||.| .|. .| | |  |..| || | .. .
lkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvheav
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 348-580 1.4e-20 67.9 In-house 49-282 (302) alignment 
Range on Protein: 348-580
Range on HMM: 49-282/302.0
PANKNKNRYANIVAYDHSRVVLERvngdEDSDYINASFIHGYDGTpRSFIASQGPLPP---AFEGFWRMVWEQNSQSIVMLTNLVELGKtKCHKYWP---
 .| .||.  .. ..|. .| ||     |  .|.||| ..  . | || | .| |      . | |||||.... .|.|.|    || |   ....|   
kknlkknqsedvpildsnlvklea....epdsyvnaskvevPelt.rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkks

DKIETYGGVTVTLHQSEIFADYEiRTFIL--SKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVERTGTYIVIDAM
.. ..|| . |   . |   . .   ...       | | ..   ..| |..| ||.  ... .   || |..     ....    |. | |. ..  . 
gdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlava

LEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVL
.|. .|.  . | . ....|..||..|.. .|| ... |.|
veklqkgkepnikeivksiRsqRpravdslkQyvslyiall
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 641-876 8.2e-20 65.4 In-house 50-285 (302) alignment 
Range on Protein: 641-876
Range on HMM: 50-285/302.0
QNLHKNRFSDIIALNSCRVMLHNEhadeESDYINAVFLHAHRGRNAFIATQHPLLETV---EDFWRMVTDYDIGTIVMLNNLHELDQEYPQYWP-DHGA-
.||.||.  |. .|.| .| |..|    . .|.||  ..    ..  | .| | ....   |.||||| .  | ..|.|    ||..   ...|   |. 
knlkknqsedvpildsnlvkleae....pdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgdy

TKYGHIGVSVLSKQEK-GDVICTKLKVTRKKVRRKTQEVCHLHHvSWPDKCIPELACSVLDLLDEAqTSQQQCGNAPVLVQCSNGVGRSGTFCAISSVLE
..||.. | .   ... ...    . |  . .         ...  |..| .|.   ..     .    ... .......   ||.|| |.| .   ..|
keygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvlt.nWkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGRagafltlavave

RLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYF
.|....   . ...| || . | ||.| .|| . | ..  |.
klqkgkepnikeivksiRsqRpravdslkQyvslyialllyi
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 353-603 1.2e-19 65.5 In-house 22-280 (290) alignment 
Range on Protein: 353-603
Range on HMM: 22-280/290.0
KNRYANIVAyDHSRVVLERVNGDEDSDYINASFIHGYDGTprSFIASQGPLPPA-------FEGFWRMVWEQNSQSIVMLTNLVELGKT----KCHKYWP
..|... ..  ..||||.       .||| |...   .|    .|..| |.           | || |. . .....||| .  |  .      | || |
dqRlevpLv.eatrvvLkgygkrfnddyiHAnrvtcpngl..rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvp

DKIE---TYGGVTVTLHQSEIFADYEIRTFILSKAKRSgSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRalnpRDAGPVIVHCSAGVERTGTYIVIDA
....   ...|.||   . |   | |.|. ..   ..     |    .  | .  |..    .|.  .||.        ||||||  |. |  .   |. 
esvgeelkfkgltvkCkskekeddvetRelvvkfddee.eftvtHsllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGiSrsAalaaiil

MLEQ-AKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAV-LEALTCGNTEIQSETYNQAMQKLA
     |..|  | ... | |||| | ..........|.  .. | |   ... ...|| ..|...  
gyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllaievldqfaeeetekkakaeek
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 694-876 1.3e-19 65.3 In-house 39-221 (255) alignment 
Range on Protein: 694-876
Range on HMM: 39-221/255.0
LleTVEDFWRMVTDYDIGTIVMLNNLHELD-QEYPQYWPDHGATKYGHIGVSVLSKQEKGDVICTKLKVTRKKV-RRKTQEVCHLHHVSWPDKCIPELAC
|  ||. |....   .  ..||| ...| . ..  .|.|     |     |.| . .   ||.   |..| .   ..||..| | ..  |..|  |||| 
l..tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelar

SVLDLLDEAQTSQqqcgnaPVLVQCSNGVGRSGTFCAISSVLE----RLKTEQV--IDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYF
 .| .|  .. |.      .|.|.||.|.||| .|  . .|       |.| .   .|  .... .| . ..|.. | |  |.  .. ...
eilnilkvvrdsk......svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv
0048076 (Phosphotyrosine protein) phosphatases II 763-876 1.8e-19 65.3 In-house 37-143 (145) alignment 
Range on Protein: 763-876
Range on HMM: 37-143/145.0
RKKVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQcgNAPVLVQCSNGVGRSGTFCAISSVLErlktEQvIDVFQVIKRIRVNLPGAVESP
    .  ...........||| ..|.|.  .|..|.  .. ...  . |||| || ||||.||..|.  .|.    .. ..........|   ||||..|
tselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqrpgavpnp

TQYLFCYQIIQKYF
 |. |.|. .....
gqlrflyefelell
subfamily_CG42327_pd Subfamily CG42327 643-803 3.6e-19 63.6 In-house 29-193 (319) alignment 
Range on Protein: 643-803
Range on HMM: 29-193/319.0
LHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHR-GRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELD-QEYPQYWPDH----GAT
  |.|. ... |   ||.|..   |... |..| ..  ..  .| .||.| .| ..  ||||.| .    .|| | .|.||  .  ..|.| .    .  
kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnts

KYGHIGVSvLSKQEKGDVICTKLKVTRKKVRRKTQEVCHLHHvSWPDKCIPELACSVLDLLDEAQTS
 ||.| |. | ..| .|   .   . ..  . ...|. |  .  |..  .|    ... .| |...|
lyGdilvt.lkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
0048179 (Phosphotyrosine protein) phosphatases II 751-870 4e-19 64.2 In-house 48-139 (144) alignment 
Range on Protein: 751-870
Range on HMM: 48-139/144.0
KgdvictklkvtrkkvrrktqeVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQqcGNAPVLVQCSNGVGRSGTFCAISsvleRLKTEQvIDVFQVIKR
                      .....|..||| ..|.|.  .|..|.  .. ..   . |||| || ||||.||..|.     ..|... .........
e.....................giqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaay....lmkklg.lsleealal

IRVNLPGAVESPTQYLFCYQ
.|   ||||..| |. |...
vrsrrpgavpnpgqlrfLle
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 406-589 3.1e-18 60.8 In-house 40-226 (255) alignment 
Range on Protein: 406-589
Range on HMM: 40-226/255.0
AFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP---DKIETYGGVTVTLHQseIFADYEIRTFILS-K-AKRSGSRMVRQFHFTVWPDKGVPQYATA
. . |....  .... .|||... | |. ||..|.|   |.   .  |.||  .    ||  .||  .  . ...   . |. .... |..|  |. |  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

VLAFRRKVRalnprDAGPVIVHCSAGVERTGTYIVIDAM----LEQAKKSRTVDI--RNYLIALRKDRPHMVQTKEQYSFIHSAVLEALtCGNTE
.|   . ||     |. .|.||||.|. |. ...... .    . . ... ||..  .. |  ||. |.  ..|  | .|    ||. .   ..|
ilnilkvvr.....dsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv.fpkge
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 692-874 3.1e-18 60.3 In-house 98-286 (302) alignment 
Range on Protein: 692-874
Range on HMM: 98-286/302.0
HPLLETVEDFWRMVTDYDIGTIVMLNNLHELD-QEYPQYWPDH--GATKYGHIGVSVLSKQE-------KGDVICTKLKVTRKKVRRKT-QEVCHLHHVS
 |  .|.| .| .. .|... .| | .. | . . . .|. |.  |  |.|.  |  .| ..       | ..   ..... .|...|. . |  |.. .
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPDKCIPELACSVLDLLDEAQTSQQQcgnapVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQK
|||.  |. | . ||.|   .. ...     ||| ||.||||.||. ||   ..  ....| |. .... .|    ||| . .| ..   .. |
wpdhGapkeaytaldilkfcesykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtk
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 626-747 6.7e-18 59.5 In-house 31-164 (350) alignment 
Range on Protein: 626-747
Range on HMM: 31-164/350.0
SREIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLH--------NEHADEESDYINAVFLHAH----RGRNAF--IATQHPLLETVEDFWRMVTDYDIG
. | | ..  . |  .   |||...|.  .  || |.         .|. . .||||| .|.      .    |  |||| || .||.||.....  .. 
dsespsnDvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvk

TIVMLNNLHELDQE-YPQYWPDHGatkYGHIGVSVLS
 |..|... ||. | . .||.. .   |  | | . |
vilsltsdvelnlekcyrYWqegs...ydditvklas
subfamily_hpo-7_pd Subfamily hpo-7 689-874 1.9e-17 58.0 In-house 42-225 (263) alignment 
Range on Protein: 689-874
Range on HMM: 42-225/263.0
AtqhpLLETVEDFWRMVTDYDIGTIVMLNNLHELD-QEYPQYWPDHGATKYGHIGVSVLSKQEKGDVICTKLKVTRK--KvRRKTQEVCHLHHVSWPDKC
     |..|.. |....      ..||| . .| . ..  .|.|     |     |.| . . . ||.   |...    . ..||..| |  .. |..| 
l....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlge.KkkthtvkhysykgWiekn

IPELACSVLDLLDEAQTSQqqcgnaPVLVQCSNGVGRSGTFCAISSVLE----RLKTEQV--IDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQK
 |||| ..| .|. |. |.      .. | ||.|.|||  |  . .|       |.| .   .|  .... .| . ..|.. | |  |   .. .
dpelareilnilkvarnsk......slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLd
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 305-390 3.9e-17 56.7 In-house 4-87 (440) alignment 
Range on Protein: 305-390
Range on HMM: 4-87/440.0
KPIPIALFPEYVAKMQANggIRLENEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYD
.|| .| | .|| . .       |.|.  . .| . | . |  | || |||| ||.|||||||.|| |.|  ||||||||.| | .
rpiivadfadyvqnnrrs..rafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingie
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 406-583 5.3e-17 56.2 In-house 103-288 (302) alignment 
Range on Protein: 406-583
Range on HMM: 103-288/302.0
AFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKIE---TYGGVTVT---LH-QSEIFADYEI---RT--FILSKAKRSGSRMVRQFHFTVWPDKG
. | .| .. . |   .| |...|| .. || .|. ||..   ..|  ||.   .. . | |.| .     |  .  .| |.   . |  ..|. |||.|
tlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdhG

VPQYATAVLAFRRKVRALNPRdagpVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
 |. | . |   .   .        |.||||||| |||| . |   ..  .| .. |. . .. .|. |   ||...|  ..   |  .|
apkeaytaldilkfcesykkn....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkgl
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 640-874 7.1e-17 55.9 In-house 45-277 (303) alignment 
Range on Protein: 640-874
Range on HMM: 45-277/303.0
PQNLHKNRFSDIIALNSCRVMLHnehadeESDYINAVFLHAHRGRNAfIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQE-----YPQYwPDHG
 .|..|||| |.| |.  .| |       .| || | .|. .  ..| | || ||  |  |||.|. .  .  ...|    | |.      .|.   |  
vknmdknrfvdvicldhskvkls......dssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprn.qdfl

ATKYGHIGVSVLSKQEKGDVIctKLKVTRKKvRRKTQEVCHLHHV-SWPDKCIPEL-ACSVLDLLDEAQTSQ-QQCGNAPVLVQCSNGVGRSGTFCAISS
  .   | |  . . | ||    .|||       . .   |.||  .|| . ||   .  ..  . . |.   . . . | .     |.||.|||. . .
kfeersirvgefkrvelgdgw..vlkvlsvs.ngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfet

VLERLKTEQV-IDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQK
    |..||  .|. .... .|     ||.  .|. . | .. .
ahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllae
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 655-872 1.5e-16 55.4 In-house 31-255 (290) alignment 
Range on Protein: 655-872
Range on HMM: 31-255/290.0
NSCRVMLHNEHADEESDYINAVFLHAHRGRnAFIATQHPLLET-------VEDFWRMVTDYDIGTIVMLNNLHELDQEYP-----QYWPDHGA--TKYGH
.  ||.|..      .||| | ..    |  ..|.|| |. ..       .|.|| |. .  .  .||| . .| ...       .| |..     |.. 
eatrvvLkgygkrfnddyiHAnrvtcpngl.rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkg

IGVSVLSKQEKGDVICTKLKVTRKKVrrKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQtsqqqCGNAPVLVQCSNGVGRSGTFCAISSVLERLK-TE
. |.  || .. ||.  .| |.  .   .   | |   ..| .  ..|   ..|.|..  .     . ..||.| | .|. || .. ||      .  |.
ltvkCkskekeddvetRelvvkfdde..eeftvtHsllkgWnklnvqedtktllsliqkvk.....asktpvivHcvdGiSrsAalaaiilgyQkiaets

QVIDVFQVIKRIRVNLPGAVESPTQYLFCYQII
. . . .|.| .| .   |. |.... |    |
gsvkledvlkalrkqralaitsalelafvdagi
subfamily_CG42327_pd Subfamily CG42327 514-578 2.2e-16 54.4 In-house 245-310 (319) alignment 
Range on Protein: 514-578
Range on HMM: 245-310/319.0
RDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKS-RTVDIRNYLIALRKDRPHMVQTKEQYSFIHSA
 . ||..|||| || |||. |  |  ... ..| |.||| . .  .|.|| . |.||||| ||.  
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv
subfamily_eak_pd Subfamily eak 349-508 3.5e-16 53.5 In-house 51-207 (332) alignment 
Range on Protein: 349-508
Range on HMM: 51-207/332.0
ANKNKNrYANIVAYDHSRVVLERVNGDEDsDYINASFIHgYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKI---E
 . |.|   .|| ||.  | |     ...  ||||| .  .    | .| .  .       ||.|| ||.| .||.| . |||.  |  ||.|||     
eavnrn.vvkivpydrylvrltssqlnrl.Gyinaslae.fsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreel

TYGGVTVTLHQSEIFADYEIRTFILSKAKRsgSRMVRQFHFTVWPDKGVPQYAtAVLAFRRKV
 .| . |.  .    . .| | ..|||     .  |  ...  | .  .|.|    ||.|. .
kfGildverkefvkrniletrllelskGne..thrvlhykvfGwtettlpkye.dflalrkvm
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 507-583 3.6e-16 53.9 In-house 220-295 (297) alignment 
Range on Protein: 507-583
Range on HMM: 220-295/297.0
KVRALNPRDAgPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
 .||  ||.| ...||||||| |.|  .  |..|.. .| |  |..  |  ||. |. .||| ||. ....|||. |
slraemprna.yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 520-586 4.2e-16 53.1 In-house 2-68 (69) alignment 
Range on Protein: 520-586
Range on HMM: 2-68/69.0
IVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCG
.||||.|  ||||.| |   . . |  . ||| | .  .|| || ||  . .| ||| |. |||  |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 305-401 5.1e-16 52.6 In-house 3-95 (95) alignment 
Range on Protein: 305-401
Range on HMM: 3-95/95.0
KPIPIALFPEYVAKMQANGGIRLENEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLErvnGDEDSDYINASFIHGYDGTpRSFIASQG
||| ...|  .| .|..|    ..||.|  .     |. .    ||  |||. ||. || .||||       ||||||| |. ||      .||.||
kpihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlt...tkrdsdyinacfvdgyark.ncyiaaqg
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 520-586 7e-16 52.3 In-house 1-67 (69) alignment 
Range on Protein: 520-586
Range on HMM: 1-67/69.0
IVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCG
.||||.|  ||||.| |   . . |  . ||| | .  .|| || ||  ...| ||| |. |||  |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 350-582 7.9e-16 52.5 In-house 47-278 (303) alignment 
Range on Protein: 350-582
Range on HMM: 47-278/303.0
NKNKNRYANIVAYDHSRVVLervngdEDSDYINASFIHgYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKIE----
| .|||.....  |||.| |       || || ||...  | . .  | .| ||. .   ||.|. ||. . ...|    |  |   .  .| . .    
nmdknrfvdvicldhskvkl......sdssyihasyle.ld.sskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

-TYGGVTVTLHQSEIFADYEIRTFILSKAkrSGSRMVRQFHFTVWPDKGVPQY-----ATAVLAFRRKVRALnpRDAGPVIVHCSAGVERTGTYIVID-A
         ... |.   . ..   .|.   .   ..   |.  || . .|          .   .  .|     |. | .    .|. |.||. ... |
eersirvgefkrvelgdgwvlkvlsvsng..dyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrky..sdstptvymslsgcgragtfalfeta

MLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
 |   ..  ..|. . |  .|. | | ||   |.|.... . | 
hlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaeh
subfamily_hpo-7_pd Subfamily hpo-7 406-618 1e-15 52.3 In-house 46-260 (263) alignment 
Range on Protein: 406-618
Range on HMM: 46-260/263.0
AFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP---DKIETYGGVTVTLHQSEIfaDYEIRTFILSK--AKRSGSRMVRQFHFTVWPDKGVPQYATA
. . |....  .... .|||..  | |. || .|.|   |.   .  |.|.  ..    |  ..|  | .   ..   . |... .. |..|  |. |  
tidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpelare

VLAFRRKVRalnprDAGPVIVHCSAGVERTGTYIVIDA----MLEQAKKSRTVDI--RNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSET
.|   . .|     .  ...||||.|. |.  . |..     |. . ... ||..  .. |  ||. |.  ..|  | .|    ||. .   ... . |.
ilnilkvar.....nskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfakgelea

YNQAMQKlaSVNRKFQMTGYALEF
  | ..|  |  .  ||    |||
kyqeirk..sylharqmmhkdlef
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 646-881 1.3e-15 51.9 In-house 47-281 (312) alignment 
Range on Protein: 646-881
Range on HMM: 47-281/312.0
NRFSDIIALNSCRVMLhnehADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQEY-PQYWPDHG-AT------K
||. .|   .  |  |    | .|  || | |..     . |..|| || .|.  ||...      .|..|  . |   |   .|  |            
nrypniqcwdrgrftl....agdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrv

YGHIGVSV-LSKQEKGDVICTKLKVTRKKVRrKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSqqqcgNAPVLVQCSNGVGRSGTFCAISSVLERL
|      . .  . |  .    |||  |    .   . |    ||||. .|.   . | ||   .       . ||. .|| ||||.||.. | |..  |
yteycteieiggkskdkithrvlkvvvkatg.qesklnhyqwaswpdhgmpdscdtalrllsavkkd.....kkpviahcsagvgrtgtlaliesmiaal

KTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFDSFSD
.  .  .| ..   .| .   .|.   ||... ... ... | . 
rhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskgl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 683-733 9.3e-14 45.6 In-house 234-282 (440) alignment 
Range on Protein: 683-733
Range on HMM: 234-282/440.0
GRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHelDQEYPQYWPDH
 .||||||| ||  || ||||.| || | ||.|||.|   |.    |||  
kknafiatqmpldstvldfwrlvhdyristiimlnqln..dktcsiywpvn
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 578-745 8.6e-13 42.5 In-house 34-195 (244) alignment 
Range on Protein: 578-745
Range on HMM: 34-195/244.0
AVLEALTCGNTEIQSETYNQAMQKLASVNRKFQMTGYALEFQRLNSVtSREIPAEEKSVgEEPQNLHKNRFSDIIALNSCRVMLHNEHAdeESDYINAVF
||| | .. |  |.   ....   |.| ...      |   |  ...  |  |.  | .  .|.| .||| .  . ..  || | .        |||| |
avlsanatknryinilpfdetrvilssskkegsdyinanyiqgsqni.irpdpsvmkda.fnpnnswknregaglpfdfnrvplskgsm..gntyinasf

LHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQeypqYWPDHGATKYG--HIGVSV
.        .| ||||| .|  |||.|. .  .  .|.|  . | |.    ||||    ..    | |..
vgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede....ywpdseplewyeeditvtl
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 352-458 9.5e-13 42.2 In-house 50-169 (349) alignment 
Range on Protein: 352-458
Range on HMM: 50-169/349.0
NKNRYANIVAYDHSRVVLERVN--------------GDEDSDYINASFIHGYDGTP-RSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKC
 |||| .|. |.||||.|..                .    ||||| ...    .. . .|| | ||| . . |....  .. . .. |..  ||.  ||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

HKYWPDKieTYGGVTVTLHQSE
..|| .   .| ..|| |  | 
diywqel..sysnitvklqnss
fn3 Fibronectin type III domain 1-82 1.5e-12 40.7 Pfam-A 3-85 (85) alignment 
Range on Protein: 1-82
Range on HMM: 3-85/85.0
PSSLNSKAMTSTSIRVTWSTLPetCTNGIVRKYVISYHKDGGSN-ETTEVIGAPT-SFDINNLAKYTKYTIKVRGYTLK-EGPWS
|. |. ...||||....||  .    .| . .| . | ..||.. ...  . ..| |. ...|  .|.|...|. .. . |||.|
PenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 514-580 3e-12 40.9 In-house 260-341 (350) alignment 
Range on Protein: 514-580
Range on HMM: 260-341/350.0
RDAGPVIVHCSAGVERTGTYIVIDAMLE-------QAKKSRTVDIRN--------YLIALRKDRPHMVQTKEQYSFIHSAVL
  . |..||||||| ||||.. .| .|.         |.|| .|  .         .  ||| |  |||...|. ||. |.|
arsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeall
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 329-444 2.1e-11 37.0 In-house 6-88 (169) alignment 
Range on Protein: 329-444
Range on HMM: 6-88/169.0
NEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINAsfihgydgtprsfiasqgplppafegfwRMVWEQNSQSIVMLTNL
|| |.| .  ..    |   .|. ||| |  .|  | || |.||  |  ||||||                            ||.|| |.  ||.| . 
nelkefmktieynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlgdt

VElgktkCHKYWPDKI
 .        .||.| 
dd.....knnfwpeke
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 329-444 2.5e-11 36.7 In-house 5-87 (169) alignment 
Range on Protein: 329-444
Range on HMM: 5-87/169.0
NEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINAsfihgydgtprsfiasqgplppafegfwRMVWEQNSQSIVMLTNL
|| |.| .  ..    |   .|. ||| |  .|  | || |.||  |  ||||||                            ||.|| |.  ||.| . 
nelkefmktieynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlGdt

VElgktkCHKYWPDKI
 .        .||.| 
dd.....knnfwpeke
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 345-493 3e-11 37.4 In-house 91-234 (244) alignment 
Range on Protein: 345-493
Range on HMM: 91-234/244.0
ARKPANKNKNRYANIVAYDHSRVVLERvnGDEDSDYINASFIhGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVElgktkCHKYWPDK-
| .| |  ||| .  . .| .|| | .  |     ||||||. |  |    .| .| ||  .   ||.|. |.  . .|.|  . |       .||||  
afnpnnswknregaglpfdfnrvplsk..gsmgntyinasfv.gclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsvee.....edeywpdse

-IETYG-GVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKG
 .| |   .|||| . . | .     . .        . .  |  . ||  |
plewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdg
subfamily_CG42327_pd Subfamily CG42327 803-876 3.7e-11 37.3 In-house 241-315 (319) alignment 
Range on Protein: 803-876
Range on HMM: 241-315/319.0
SQQQCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTE-QVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYF
| ..  . |. | ||.||||.|.  |    ...|..  . .|. |..  .| .   || .  || | |.....| 
sgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 684-876 5.8e-11 35.6 In-house 114-309 (346) alignment 
Range on Protein: 684-876
Range on HMM: 114-309/346.0
RNAFIATQHPLLE---TVEDFWRMVTDYDIGTIVMLNNLHELDQEYPQYWPDHGaTKYGHIGVSVLsKQEKGDVICTKLKVTRKKVRRK--TQEVCHLH-
 . .| .| | .|    ||||| |. . .|  . ..     | .     . |     | . |  .. .. . ||     . | . .        .|..| 
ehklivaqlpqmenesfvedfwymiyqeqihlvylmvpddklkntttslfnden.ggyqytgkmfi.nnrradvsgdpkeytievlpegnsdsvicqvhh

HVSWPDKCIPELACSVLDLLDEAqTSQQQCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYF
|  |     |  .  .. .. .   |..|  || | |    | ||. .|      ...|      ......| |. . ||.||| .||   | |.  | 
hapwkhlqqppktlpiikmihqf.lsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyi
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 638-715 6.2e-11 36.4 In-house 33-115 (347) alignment 
Range on Protein: 638-715
Range on HMM: 33-115/347.0
EEPQNLHKNRFSDIIALNSCRVMLHNE-----HADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVM
|  ..| |||  |    .. ||.|  |     .||.   ||||  ..    .. .| ||.|| .|| |||.||.   .  .| 
ewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt
subfamily_eak_pd Subfamily eak 620-788 1.4e-10 35.1 In-house 28-196 (332) alignment 
Range on Protein: 620-788
Range on HMM: 28-196/332.0
RLNSVT--SREIPAEEKSVGEEPQNLHKNrFSDIIALNSCRVMLHNEHADeESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLN
|.| |.   .  ..  .|...  .....|   .|.  .   | | .   . .  ||||  .      . .| |  .  . |  ||.|| .    .||.| 
rinivadlddyqrllsisetarleavnrn.vvkivpydrylvrltssqln.rlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqll

NLHELD-QEYPQYWPDHG--ATKYGHIGVSVLSKQEKGDVICTKLKVtrkKVRRKTQEVCHLHHVSWPDKCIPE
.  ||. ... .|.||..    |.|.. |   .  ... .   .|..   ..  .| .| | .   | .  .| 
edvelkleksdkyfpdktreelkfGildverkefvkrniletrllel...skGnethrvlhykvfGwtettlpk
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 669-783 2.7e-10 34.6 In-house 12-123 (130) alignment 
Range on Protein: 669-783
Range on HMM: 12-123/130.0
ESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDqeypQYWPDHGATK-Y-GHIGVSVLSKQEKGDVICTKLKVtRKKV
. .|||| |.      . .. ||||| .|  |||.|. .  .  .|.|  . | |    .||||    . |  .| |..  ..|   .  ..|..  ...
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed....eywpdsePlewyeediivtltdrdefknikasnlei.esdl

RRKTQEVCHLHHVSWPD
 .  | .  ..   || 
neshqaltmfqisnwps
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 813-870 6e-10 33.4 In-house 2-59 (69) alignment 
Range on Protein: 813-870
Range on HMM: 2-59/69.0
LVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQ
.|.|| | ||.||| ||   . |.|.|...|.|  .. .|   |  |    .|.| . 
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihd
subfamily_eak_pd Subfamily eak 517-591 8.9e-10 32.5 In-house 238-313 (332) alignment 
Range on Protein: 517-591
Range on HMM: 238-313/332.0
GPvIVHCSAGVERTGTYIVIDAMLE--QAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQ
 | |. .. |  |.|...||| ...  ..||  .  . ....  .. | | | .. |.|||. .||. |   | ...
ap.iiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnrlr
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 814-870 1.1e-09 32.5 In-house 2-58 (69) alignment 
Range on Protein: 814-870
Range on HMM: 2-58/69.0
VQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQ
|.|| | ||.||| ||   . |.|.|...|.|  .. .|   |  |    .|.| ..
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihd
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 631-733 4.2e-09 30.2 In-house 37-156 (349) alignment 
Range on Protein: 631-733
Range on HMM: 37-156/349.0
AEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHN--------EHADEE------SDYINAVFLHAHRG--RNAFIATQHPLLETVEDFWRMVTDYDIGTIV
...  . |  .   |||..||.  .  ||.|..        ...  |       ||||| .|.  |    . .|||| ||  ||.||.....   .  ..
iddvilseGvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvl

MLNNLHELDQEY-PQYWPDH
 ||. .||. |   .|| . 
sLnddkelslekcdiywqel
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 773-876 7.5e-09 29.8 In-house 217-344 (350) alignment 
Range on Protein: 773-876
Range on HMM: 217-344/350.0
VCHLHHVSWPDK---CIPELACSVLD----LLDE--AQTSQQQCGNAPVLVQCSNGVGRSGTFCAISSVLE---RLK---T--------EQVID-VFQVI
| .|.   |.|      ||   ..|.    |.|.  |..  ..   .|.|| || |||| ||.... |.|.    |.             .. | .....
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

KRIRVNLPGAVESPTQYLFCYQIIQKYF
...|      | . .|..|.|. .. ||
nelrkqrismvqnldqfifiYeallfyf
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 350-423 8.2e-09 29.4 In-house 37-114 (347) alignment 
Range on Protein: 350-423
Range on HMM: 37-114/347.0
NKNKNRYANIVAYDHSRVVLER-----VNGDEDSDYINASFIHgYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIV
. .|||  .    | .||||        . |.   ||||| |. .| . . .| .| ||| .   ||.||   .   .|
slsknrskdvklidatrvvlspeksknsraddvetyinashik.fdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvv
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 349-433 1.7e-08 28.3 In-house 33-115 (332) alignment 
Range on Protein: 349-433
Range on HMM: 33-115/332.0
ANKNKNRYANIVAYDHSRVVLERVNGDedSDYINASFIHGYDGTpRSFIASQGPLPPAFEG-FWRMVWEQNSQSIVMLTNLVELGK
 | . ||   . ..||||| |   .|    |. |||.. ||     ..| .| |.    |  ||||| |..   |... .. |  |
nnmdmnriphlycfdhsrvelapqdgk..ddfynaswvdgyskk.sayifaqapfndhteyvfwrmvserkpsmilvfgdidekqk
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 430-576 1.9e-08 28.1 In-house 144-295 (332) alignment 
Range on Protein: 430-576
Range on HMM: 144-295/332.0
ELGKTKCHKYWPDKIETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDK-GVPQYATAVLAFRR--KVRALN--PRDAGPVIVHCS
||    |.|.||.|       ..... |. ...  ..|| |. ...   .    .||  | |   .|.|   . |  .   .|. .      ||... |.
elkakicrkfwpekrskkdfpalsiqasddhsethmktfnltvtekkqdhqtvlmhfyewadasklpeymldmrasiklqyirsskktgvcigpimlvca

AGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIH
.|||.   .  || .. .  . . | ... . |.. .|   ..|   ||   
tgvekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpystac
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 634-691 7.3e-08 26.5 In-house 40-94 (95) alignment 
Range on Protein: 634-691
Range on HMM: 40-94/95.0
KSVGEEPQNLHKNRFSDIIALNSCRVMLHNEhadEESDYINAVFLHAHRGRNAFIATQ
 .||    |. |||| .|.  .. ||.|       .||||||.|.  .  .|..||.|
ytvgsseanipknrflnifpydatrvvlttk...rdsdyinacfvdgyarkncyiaaq
fn3 Fibronectin type III domain 97-170 1.1e-07 25.1 Pfam-A 2-85 (85) alignment 
Range on Protein: 97-170
Range on HMM: 2-85/85.0
PPLGVNHTEIYSTTFNISWDPIPkdQSNGIITSYDLELI------------LNSTLTYIVLHNLENCTIYHLRVRARTGKGPGPYS
.| ... .|. ||....||.| .  . .| ||.|..|.             . .| |  .|..|.  | |..||.|..|.| ||.|
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 515-581 1.1e-07 25.5 In-house 264-342 (349) alignment 
Range on Protein: 515-581
Range on HMM: 264-342/349.0
DAGPVIVHCSAGVERTGTYIVIDAMLE----QAKKSRTVDIRNY-------LI-ALRKDRPHMVQTKEQYSFIHSAVLE
.  ...||||||  |||... .| .|.      ..|  .....         .  ||| |  |||   |. .|. |.|.
qlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLk
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 340-390 2.3e-07 24.7 In-house 29-78 (244) alignment 
Range on Protein: 340-390
Range on HMM: 29-78/244.0
FPWEAARKPANKNKNRYANIVAYDHSRVVLERVnGDEDSDYINASFIHGYD
|    |   ||  |||| ||. .|..||.|      | ||||||..|.| .
flqtnavlsanatknryinilpfdetrvilsss.kkegsdyinanyiqgsq
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 394-470 3e-07 24.1 In-house 236-311 (440) alignment 
Range on Protein: 394-470
Range on HMM: 236-311/440.0
RSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVElgkTKCHKYWPDK--IETYGGVTVTLHQSEIFADYEIRTFIL
 .|||.| ||  .   |||.| . .  .|.|| .| .     |  ||| .    |.|  ||  . || .    .||. |
nafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlel
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 362-493 3.4e-07 24.6 In-house 5-125 (130) alignment 
Range on Protein: 362-493
Range on HMM: 5-125/130.0
YDHSRVVlervngdeDSDYINASFIhGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVElgktkCHKYWPDK--IETY-GGVTVTLHQSE
.. ||.         . .||||||. |  |  . .. .| ||  .   ||.|. |.    .|.|  . |       .||||   .| |   ..||| . .
fevsrlq........gntyinasfv.Gllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsvee.....edeywpdsePlewyeediivtltdrd

IFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKG
 |   .   .  ..      . .  |. . ||  |
efknikasnleiesdlneshqaltmfqisnwpsdg
subfamily_PTPDC1_pd Subfamily PTPDC1 487-576 2.1e-06 22.3 In-house 88-169 (182) alignment 
Range on Protein: 487-576
Range on HMM: 88-169/182.0
TVWPDKGVPQYATAvLAFRrKVRALNPrDAGPVIVHCSAGVERTGTyiVIDAMLEQAKKsrtVDIRNYLIALRKDRPHMVQTKEQYSFIH
  |.| ||.   .. |    || |    . | | ||| ||  |||   .| ..|  ||.   ..  . .  .|. ||. .||.||  ...
fgwkDygvasleri.Ldiv.kvvafal.qegkvavhChaGlGrtGv..liacylvyakr...ltaekaiklvrskrpksiqtreqvelvk
0038934 (Phosphotyrosine protein) phosphatases II 485-576 2.6e-06 22.7 In-house 83-170 (194) alignment 
Range on Protein: 485-576
Range on HMM: 83-170/194.0
HFTVWPDKG-VPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVERTGTYIVIDAMLeqakkSRTVDIRNYLIALRKDRPHMVQTKEQYSFIH
.   .||.| ||....    ..   . ||    | | ||| ||. |||| ..   .      ..  . .  .  .|  ||..... .... ..
lklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiy.....rlgmsaeeAialfrekRpgaipnqdyleall
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 800-838 9.9e-06 19.1 In-house 256-294 (349) alignment 
Range on Protein: 800-838
Range on HMM: 256-294/349.0
AQTSQQQCGNAPVLVQCSNGVGRSGTFCAISSVLERLKT
|.   ..   ...|| || | ||.|... . ..|. |. 
arlyldtdqlstllvhcsaGcGrtGvlvtldlllsilep