Gene NvecPTP-sf2-6 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily NvecPTP-sf2
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP049_AA protein Get Run
NvecP049_AA_309-584 phosphatase_domain Get Run
NvecP049_AA_596-877 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 304-766 1.2e-237 785.1 In-house 2-463 (564) alignment
Range on Protein: 304-766
Range on HMM: 2-463/564.0
SKPIPIALFPEYVAKMQANGGIRLENEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPL
|||||.| ..|.|||..||.....|.||||...||||.||||.|||||.|||||||||||||||||..|.|||.|||||||||.||. .....||.||||
skpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPl

PPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK-IETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVL
....| ||||||||||..|||||.|.| ||.|||||||.|  ||||..||||...| .||||||||.|.|.|.| ||.||||||| |||.|||..||..|
aetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslL

AFRRKVRALNPRDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSETYNQAMQKL
...|||||||..||||..|||||||.||||.||||||||..|...||||..|..||||.|..||||.|||.|||.|.||||.|||||..||...|..|||
dlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkL

ASVNRKFQMTGYALEFQRLNsvTSREIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFW
|.|.....|||..||||||.  |..||..||..|...|.|..|||||.|.||.||||.|....|.||||||||..|.|.|...||||||.|| .||||||
aeveedtemtgleleFqrLa..takeieleefavatkpknkkknrfsnilalescrvvlsairakeesdyinasyleayrekrafiatqaplkntvedfw

RMVTDYDIGTIVMLNNLHE-LDQEYPQYWPDHGATKYGHIGVSVLSKQEKGDVICTKLKVTRKKV
|||.......||||..|.| |..|. .|..|..|||||.|...||.|.||.|....| ||..|. 
rmvweeevkiivmltkleekleeesseyysdleatkyGeitikvlkkkeksdilfrkkkvevkek

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 586-883 2.3e-145 478.4 In-house 1-297 (298) alignment
Range on Protein: 586-883
Range on HMM: 1-297/298.0
GNTEIQSETYNQAMQKLASVNRKFQMTGYALEFQRLNSVTSrEIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRN
|||||..|....|.||||.|..|...|||||||||||||.| ||..|||.|...|.| .|||..|||||.|.||.|..|.||||||||||.||||..|||
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvss.eieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn

AFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ-EYPQYWPDHGATKYGHIGVSVLSKQEKGDVICTKLKVTRKKVRrKTQEVCHLHHVSWPDK
||||||.|| |||||||||||..||||||||.||.|||. .|..||||.|...||.| ||.|||.|..|.|..||||..||.. |..||..||..|||||
afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdk

CIPELACSVLDLLDEAQTSQQQCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFDSFSDYA
..|| |.||||||.. ..||||.||.||.||||.||||||||.||.|||||.|.|||.|||||.|..|.. ||||.. .|| |.|.......|||.|..
gvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 301-591 6.8e-137 450.6 In-house 3-298 (298) alignment
Range on Protein: 301-591
Range on HMM: 3-298/298.0
DDLSKPIPIALFPEYVAKMQANGGIRLENEYKKFNNGQQ----FPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPrSF
....... .|......|...... .....|....|....    . .|.||||.||.|||||.|.|.|.||||||....||.||||||||.|.|.|.. .|
teieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn.af

IASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPD-KIETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVP
||.|.||....|.|||||.|.....|||||||.||.|||.|||||| . |||| .||.|...| |||...|....||.|....|.|||.|||.|||||||
iatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvp

QYATAVLAFRRKVRAlNPRDAG--PVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQ
..||.||...||||| ....||  ||||.|||||.|.||.|.||..||..||...||.......|||.||..|||.|||.||..||||||...|.||.
enatsvldllrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndeie

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 344-592 8.9e-124 406.6 In-house 3-245 (250) alignment
Range on Protein: 344-592
Range on HMM: 3-245/250.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTkCHKYWP-D
 |.||.||.|||||.|.|.|.||||||...||..||||||||.||||.. ..|||.||||....|.|||||.|..|..|||||||.| .|| .|.||| .
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve

KIETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR-DAGPVIVHCSAGVERTGTYIVIDAMLE
| |.||.|||.|...|.||||..|...|||||....|.|||.||.||||||||..|||||....||.| ... ...||||.||||| |.|..|.|||.||
kaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavle

QAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCgnteiqS
..||...||.......|||||||.|...|||.|.....|.||..      .
rlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds......v

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 634-884 3.9e-122 401.3 In-house 1-250 (250) alignment
Range on Protein: 634-884
Range on HMM: 1-250/250.0
KSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQEYPQYWPDH
|||...|||..|||..|||||.|.||.|..|..|.|||||||.|||....|.||||||.|| .|.|||||||.....||||||.||.| ...|.||||  
ksvakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPve

GATKYGHIGVSVLSKQEKGDVICTKLKVTRKKvRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQCGNAPVLVQCSNGVGRSGTFCAISSVL
.|.|||.. ||.|||.|..|.. .|||....| . . . | .||.|.||||..|| | .||.||.. |.||||.|||||.||||.||||||.|.||..||
kaekyGdvtvsllskeefadytkrklklskak.kaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavl

ERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFDSFSDYAN
||||.|.|.|||.|||..| . |.|||| .|| |.|.||.|. ||..|||.
erlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedyar

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 307-621 1.4e-113 374.2 In-house 2-318 (318) alignment
Range on Protein: 307-621
Range on HMM: 2-318/318.0
IPIALFPEYVAKMQANGGIRLENEYKKF-NNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPP
|..  . . |......| . |..||...  . ... .  . .|.||.|||||||.||||.|| |. ..|.|.||||||..| ||    ...||.|.||| 
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyr.rkkayiaaqaPlpe

AFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKI-ETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAF
..| ||||||||||. |||||...| ||.|.|.|||.|  ..|| ..|.|...  ..|| .|.| ... . . ||.|||.|.| |||.|||. .. .|..
tieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldl

RRKVRALN-PRDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSETYNQAMQKLA
 |.|.. . . .|||..||||||| |||..|..|..||..|.  .||. ..   ||. |. ||||..|| ||. ..||||..|.||....  .. ...| 
vrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelr

SVNRKFQMTGYALEFQRL
 .. .  .|   .|||||
eqdpesgttemdaefqrl

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 305-619 2.4e-106 350.4 In-house 3-319 (319) alignment
Range on Protein: 305-619
Range on HMM: 3-319/319.0
KPIPIALFPEYVAKMQANGGIRLENEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLP
..|... . |.. .....|   ||.|.|........ .. | |. ||.|||| ||.|||..||||  ..| |.||||||||| ||.   . ||| |.|| 
teievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqer.ekfiatqaPle

PAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKI-ETYGGVTVTLHQSEIFADYEIRTFILSKAKRSG-SRMVRQFHFTVWPDKGVPQYATAVL
 ..| |||||||..|  .||||.||| .| |..||||..  |.|| ..||| . |  .||.|| . | |..    .|.| .|..| |||..||..||..|
ntiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatsll

AFRRKVRALNPR-DAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSETYNQAMQK
.. ...|    . ..||..||||||| ||||.||.|||||. |.  ..|. ..   ||  |. |||..|||.||. |.|||...|.|||. .  .. ...
dllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkq

LASVNRKFQMTGYALEFQ
||. . .  .|| . |||
laekvadtgetglerefq

subfamily_PTPRG_pd Subfamily PTPRG 307-597 7.9e-102 336.3 In-house 1-301 (563) alignment
Range on Protein: 307-597
Range on HMM: 1-301/563.0
IPIALFPEYVAKMQANGGIRLENEYK---KFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDS-DYINASFIHGYDgTPRSFIASQGP
.|.  | ..||.. |.| |....|..   .  . .... |...|| ||.|||| ||||||.||| |. . | ... |||||..|.||    . |||.|||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyq.kskafiatqgp

LPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP-DKIETYGGVTVTLHQSEIFADYEIRTFILSK--AK----RSGSRMVRQFHFTVWPDKGVP
|.  |. ||||.||||.. |||.||||| |. ||. ||| |. |||| ..||| ..|..| | .||... .   |    .   ..|||.|.| |||.|||
lkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvP

QYATAVLAFRRKVRALNPRDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSETY
.... || | .|  | |...|||..||||||| |||||||.|..|.| ..  .|.. . |  .|  |...|||.||| |.| |.|||.. ..||...|  
ehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqv

NQ
..
ee

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 343-581 2.7e-101 332.7 In-house 1-239 (239) alignment
Range on Protein: 343-581
Range on HMM: 1-239/239.0
EAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPD
|||.|  || ||||||||.|||||||||... |  |||||||... |||.|...||.|| . ..   ||||.|..    ||||| |.|  | |||.||||
eaakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd

KIETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVERTGTYIVIDAMLEQ
    |  . |||...|.|||| ||||..|.  ..  | | |.|||||||||||||||||| .|||.   .   | | ..|||||| |||...|||||| |
stskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq

AKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
||| .|||| ||. |.|.|||||||| ||| ||| ||||
akkqktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 344-582 2.9e-101 332.6 In-house 1-239 (239) alignment
Range on Protein: 344-582
Range on HMM: 1-239/239.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK
||.|  || ||||||||.|||||||||... |  |||||||... |||.|...||.|| . ..   ||||.|..    ||||| |.|  | |||.|||| 
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

IETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVERTGTYIVIDAMLEQA
   |  . |||...|.|||| ||||..|.  ..  | | |.|||||||||||||||||| .|||.   .   | | ..|||||| |||...|||||| ||
tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

KKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
|| .|||| ||. |.|.|||||||| ||| ||| |||||
kkqktvdifnyvkairedrphmvqtseqyvfihlavlea

subfamily_PTPRB_pd Subfamily PTPRB 304-585 2.7e-100 330.2 In-house 4-287 (293) alignment
Range on Protein: 304-585
Range on HMM: 4-287/293.0
SKPIPIALFPEYVAKMQANGGIRLENEYKKFNN-GQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGP
|||| .  | |.|.||.|.  .|. .||..... |..   .||....|..|||| ||..|||||| |. ......||||||..|.||  .|| |||.|||
skpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgyn.sprefiatqGP

LPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK--IETYGGVTVTLHQSEIFADYEIRTFILSKakRSGSRMVRQFHFTVWPDKGVPQYATA
|| ... |||||||..|. |||||.||| ||.||..|||..    .|| ..||| ..|   |. ||.. ..|  .. .| |||.||| ||| |||. ...
lpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektkt

VLAFRRKVRALN--PRDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTC
.|.| |.||       ...|..||||||| ||||.| .| .|.. ... .|||   ...||..| ..|||..|| |||..||. |. 
lldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk

0040438 (Phosphotyrosine protein) phosphatases II 312-605 1.3e-98 325.5 In-house 5-298 (317) alignment
Range on Protein: 312-605
Range on HMM: 5-298/317.0
FPEYVAKMQANGGIRLENEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRsFIASQGPLPPAFEGFW
..... .. ...  .|..|.... . .  ... |..|.||.|||| .|. ||||||.|  ..||.||||||||...|.. ... ||| |||||  .| ||
lllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrk.fIatqgPlpntvedFw

RMVWEQNSQSIVMLTNLVELGKTKCHKYWP-DKIETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRA
||||||....|||||.|.|||. ||..||| ..  |||..|||| . |  |....||. ... . | ||.|..||.| ||| |||.. . .|.| ..||.
rmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavre

LNPRDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSETYNQAMQKLASV
 .... |||.||||||| ||||.|... |||| .| ..||. . .  ||. ||..||| ||| |.. |.|| |....| .    .  ...||  .
aledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllkllip

0051299 (Phosphotyrosine protein) phosphatases II 305-583 2e-98 324.6 In-house 3-286 (288) alignment
Range on Protein: 305-583
Range on HMM: 3-286/288.0
KPIPIALFPEYVAKMQANGGIRLENEYKKFNNGQ-QFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRsFIASQGPL
..|..  . ..| |..|||  .|..|.... . . .... ||..|.|..|||| .|..||||||.|  ..|.|.|||||||.|.||. . . ||| ||||
teisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk.fIatqgPl

PPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP-DKIETYGGVTVTLHQSEIFADYEIRTFILSKA----KRSGSRMVRQFHFTVWPDKGVPQYA
|  .| |||||||||.. |||||.|||||..||..||| .. .||| .||||   |...|| .||.....     . . ||.|..||.| ||| |||...
pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

TAVLAFRRKVRALNPRDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
...|.| |.||  .. . |||.||||||| ||||.|..| .||| .| ..||. ...  ||. ||.|||| ||| |.. |.||.|
ellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

0050432 (Phosphotyrosine protein) phosphatases II 307-587 5.6e-98 323.3 In-house 26-303 (308) alignment
Range on Protein: 307-587
Range on HMM: 26-303/308.0
IPIALFPEYVAKmqANGGIRLENEYKKFNNGQQ-FPWEAARKPANKNKNRYANIVAYDHSRVVLervngDEDSDYINASFIHGYD-GTPRSFIASQGPLP
...  . ... |  |..  .|| |...... .  .....|..|.||.|||| .|..||||||.|     ||.|||||||...||. . || ||| |||||
lsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlp

PAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK----IETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATA
  .| |||||||||.. |||||.||| |. ||..|||..    ...||..||||   |...|| .||..|.. . . ||.|..||.| ||| |||.....
ntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspei

VLAFRRKVRALNprDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGN
.|.| ..||  .  . ||..||||||| ||||.|..| .||| .| ..||. ...  ||. ||.||||.||| |.. |.|| | .  
lldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl

subfamily_PTPRA_pd Subfamily PTPRA 305-617 3.2e-97 320.4 In-house 12-329 (330) alignment
Range on Protein: 305-617
Range on HMM: 12-329/330.0
KPIPIALFPEYVAKMQANGGIRLENEYKKFNN-GQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPL
 |.|.  . | . . .|.   .. .|.. .     |   |.| |  ||.|||. ||. ||.|||.|  ..| |.|||||||||.||     .|||.|||.
fplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykek.dkfiaaqGPk

PPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK-IETYGGVTVTLHQSEIFADYEIRTFILS----KAKRSGSRMVRQFHFTVWPDKGVPQYA
  . | ||||.|||.|..|||||.| |  ..||..||||. . ||| ..|.......  || .| |..     ....  ||.||||||| ||| |||  .
eetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfep

TAVLAFRRKVRALNPRDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSETYNQA
  .| . .||..||.. |||..||||||| ||||.||.||.||. |  | ||. . .  ||. ||.||||.||| ||. ..||    |.||..  . .. 
iGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekh

MQKLASVNRKFQMTGYALE
.||| .   ... .|   |
lqklynkitgtdkigleee

subfamily_PTPRK_pd Subfamily PTPRK 316-600 4.4e-97 319.7 In-house 13-294 (314) alignment
Range on Protein: 316-600
Range on HMM: 13-294/314.0
VAKMQANGGIRLENEYKKFNNGqqfpWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVW
.|..... |  . .||. . .|    |.||.|  |..|||. .|.|||.|||.|  ..|| .||||||..| .|   |. ||. ||||.   . |||.|.
iallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsyk.rpaafivtqgPlqetvkdfWrlvy

EQNSQSIVMLTNLVELGKTKCHKYWPDKIETYGGVTVTLHQSEIFADYEIRTFILSKA--KRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNP
..|. ||||||.||| |. || ||||.. |.|| . |.| ..|. |.. .|.| ..|.  . .. |.||||.|. ||| .||..||..|.. |.| . ..
dencasivmltelvevgrvkClkyWPedtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqe

RDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSETYNQAMQ
 .||...||||||  ||||.|.|| .|. ... ..||. |   .||. .. ||.|.||| ||. ..|||  ||.| |    .. .  
eeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalyl

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 305-603 9.5e-96 315.4 In-house 4-299 (315) alignment
Range on Protein: 305-603
Range on HMM: 4-299/315.0
KPIPIALFPEYVAKMQANGGIRLENEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLP
.|||.  .  |||. .|.    ....|.    || .| . |.|  ||.|||| ||.|||.||| |  .. |..|||.||.|| ||.  .| .||.|||..
qpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGyn.kkrryiaaqgpnv

PAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKIETYGGVTVTLHQSEIFADYEIRTFilSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAF
 . . |||.|.|..   |||||||||  | |. ||||||  .|| .|||. . |.. .| .||.  |   ..  | | |.|.| ||| |||.|..... .
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviyGkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnl

RRKVRALNPRDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSETYNQAMQKLA
 |.|.  .  ..|...||||||| ||||.| .||.|.||.  . .|. |..  .|. | .|||. ||| ||..|.||.. ||.| |  . | |  . | 
irtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqrydsll

0046845 (Phosphotyrosine protein) phosphatases II 327-588 9.8e-94 309.2 In-house 2-279 (284) alignment
Range on Protein: 327-588
Range on HMM: 2-279/284.0
LENEYKKFNNGQQF---PWEAARKPANKNKNRYANIVAYDHSRVVLERVNGD-EDSDYINASFIHGYD----GTPRSFIASQGPLPPAFEGFWRMVWEQN
|| |... .. . .   ....|..|.|..|||| .|..||||||.| ...|| |||||||||...|||     ... ||| |||||  .| |||||||||
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

SQSIVMLTNLVELGKTKCHKYWPDK--IETYGGVTVTLHQSEIFADYEIRTFILSKAK-RSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNP--
.. |||||.||| |..||..|||..    |||..||||   |.. || .||. |.. .  . ||.|..||.| ||| |||.... .|.| |.|| |..  
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

RDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSR---TVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNT
 . ||..||||||| ||||.|..| .||| .| .   .||. ...  ||. ||.|||| ||| |.. |.||.| ...|
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt

0043336 (Phosphotyrosine protein) phosphatases II 307-581 1.4e-92 305.4 In-house 2-275 (278) alignment
Range on Protein: 307-581
Range on HMM: 2-275/278.0
IPIALFPEYVAKMQANGGIRLENEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRsFIASQGPLPPA
|..  ........ .|.  .|..|...... . .... |..|.||.|||| .|..||||||.|. ..||.||||||||.. ||. ... |||.|||||  
isvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprk.fiatqgPlpet

FEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKIETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRR
.| |||||||.....|||||.|||||..||..|||.. .|||..||||   | ..|| .||. ... . . ||.|...|.. ||| |||   . .| | .
vedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflk

KVRALNPRDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
.||  .. . |||.||||||| ||||.|... .|||..| ..||. . .  ||. ||..||| .|| |.. |.||
avrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle

0039614 (Phosphotyrosine protein) phosphatases II 306-587 2.5e-92 304.8 In-house 13-293 (297) alignment
Range on Protein: 306-587
Range on HMM: 13-293/297.0
PIPIALFPEYVAKMQANGGIRLENEYKKFNNGQQfPWEAARKPANKNKNRYANIVAYDHSRVVLERVNG-DEDSDYINASFIHGYDGTPRSFIASQGPLP
|||.  .. .. ...||.  .|..|...  . .  ... |..|.||.|||| .|..||||||.|  ..| |.||||||||.. ||| ..| |||.|||||
piplsvldlllllekansktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlp

PAFEGFWRMVWEQNSQSIVMLTNLVELGKtKCHKYWPDKIETYGGVTVTLHQSEIFADYEIRTFILSKakRSGSRMVRQFHFTVWPDKGVPQYATAVLAF
  .| ||||||||....|||||.|||||. ||..|||.. .|||..|||| . |  ..| .||. ...   . ||.|..|..| ||| |||.... .| |
etvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeeggtygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslelllef

RRKVRALNPR--DAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGN
 ..||  . .  . |||.||||||| ||||.|... |||| .| ..||. . .  ||. ||..||| .|| |.. |.|| | ...
lelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl

0036941 (Phosphotyrosine protein) phosphatases II 327-590 1.1e-91 302.5 In-house 15-284 (297) alignment
Range on Protein: 327-590
Range on HMM: 15-284/297.0
LENEYKKFNNGQ-QFPWEAARKPANKNKNRYANIVAYDHSRVVLervnGDEDSDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQNSQSIVML
|. |.... . . ......|..|.|..|||| .|..|||.||.|    .||.|||||||.. ||| . . ||| |||||  .| |||||||||...||||
llkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrk.fIatqgPlpntvedFWrmvweqnvtvIvml

TNLVELGKTKCHKYWP---DKIETYGGVTVTLHQSEI--FADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR--DAGP
|.|||||. ||..|||   ..  |||..||||   |.  ..|| .||. ... . . ||.|..||.| ||| |||.... .|.| ..||  ..   . ||
telvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggp

VIVHCSAGVERTGTYIVIDAMLEQAK---KSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEI
|.||||||| |.||.|..| ||.| .   | ..||| ...  ||. ||..||| ||| |.. |.|| | ...| .
vlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltke

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 305-603 2.4e-90 297.8 In-house 2-303 (305) alignment
Range on Protein: 305-603
Range on HMM: 2-303/305.0
KPIPIALFPEYVAKMQANGGIRLENEYKKFNNGqQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLP
|.| .. . .|. .....    ||..||.. .  . . .  .| |||.|||...|. .|..|. |   . ..||||||||...||..   ..|..||||.
kiialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrk.kkyivaqgPlk

PAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKIET---YGGVTVTLHQSEIFADYEIRTFILSK-AKRSGSRMVRQFHFTVWPDKGVPQYATA
   . |||...|   ..|||||.||| || ||..|||...     .| ..|.|.... ..|| .| . .|.  . . || | |...| |||.||||.||.
ntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfats

VLAFRRKVRALNPRDAG-PVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSETYNQAM
.| . ..|.    .| | |..||||||| |||..|..| .||..||  .||. ..| .||. |. ||||..|| |.| |. | .|||.|.|  . .. ..
llslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarv

QKLA
.|| 
nklk

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 316-584 5.5e-90 296.3 In-house 6-277 (281) alignment
Range on Protein: 316-584
Range on HMM: 6-277/281.0
VAKMQANGGIRLENEYKKFNN-GQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGtPRSFIASQGPLPPAFEGFWRMV
......|    . .||.|... |.. . .|.....|..|||| ||||||..||.... . ....|||||.|. ||.| .. .||.|||.| ... ||.||
lkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykg.ekeyiatqgPvPaslvafWqmv

WEQNSQSIVMLTNLVELGKTKCHKYWPDKI--ETYGGVTVTLHQSEIFADYEIRTFILsKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKV-RAL
|||. . |||.|. .| || |||.||||.    .|| |||. ...|  | |  |.| | ... . .| |.|...| |||.|||. ....| ||..| .. 
weqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlklt

NPRDAGPVIVHCSAGVERTGTYIVIDAMLEQAK-KSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALT
...   |...|||||| |||||| .| ...... . ...|... .  |||.|  ||||  ||.|.. |||.|| 
ekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald

0047943 (Phosphotyrosine protein) phosphatases II 320-583 8.2e-90 296.2 In-house 7-272 (273) alignment
Range on Protein: 320-583
Range on HMM: 7-272/273.0
QANGGIRLENEYKKFNNGQ-QFPWEAARKPANKNKNRYANIVAYDHSRVVLervnGDEDSDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQN
...|  .|. |.... . . ......|..|.||.|||| .|..||||||.|    ||..|||||||.. ||. ... ||| |||||  .| |||||||||
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrk.fiatqgPlpntvedfwrmvweqn

SQSIVMLTNLVELGKTKCHKYWPDK----IETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR
.. |||||.|||||. ||..|||..     .||| .||||   |...|| .||..|.. . . ||.|..||.| ||| |||.. . .| | ..||  .  
vrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalea

--DAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
  . |||.||||||| ||||.|..| .|.| .| ..||. ...  ||. ||.|||| ||| |.. |.|| |
lpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 349-581 1.6e-89 294.2 In-house 2-237 (237) alignment
Range on Protein: 349-581
Range on HMM: 2-237/237.0
ANKNKNRYANIVAYDHSRVVLERVNGDedSDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPD--KIET
 || ||||.||||||||||||.   ..  ||||||....|.||||...||.|||| .. . ||.|||...   ||||| |.|  . |||||||.  . ..
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGGVTVTLHQSEIFADYEIRTFILSKA-KRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR--DAGPVIVHCSAGVERTGTYIVIDAMLEQA
|| .||.|.. | |.|| .|...|||  .  . |.. |..||.|||.||||...|.| ||...   .|   ..|| |.|||||| ||| ..|||||| ||
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

KKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
|. . ||| ||. .. .|||...|||.|| ||| ..||
kekkvvdiynyvysieedrpyiiqtkdqyvfihqtile

0045450 (Phosphotyrosine protein) phosphatases II 303-583 4.5e-89 294.5 In-house 5-304 (307) alignment
Range on Protein: 303-583
Range on HMM: 5-304/307.0
LSKPIPIALFPEYVAKMQANGGIRLENEYKKFNNGQQF---PWEAARKPANKNKNRYANIVAYDHSRVVLERVNGD-EDSDYINASFI--------HGYD
||..|..  .  .|.......  .|. |..|... . |   ....|..|.||.|||| .|..|||.||.|  ..|. |||||||||..        .|||
lslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgyd

GtPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK--IETYGGVTVTLHQSEIFADYEIRTFILSKA-KRSGSRMVRQFHFT
  .| ||| |||||  .| ||||.|||... |||||.|||||. ||..||||.    ||| .||||   |. ..| .||. ..   . . ||.|..||.|
l.krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhyt

VWPDKGVPQYATAVLAFRRKVRALNPR--DAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRT---VDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
 ||| |||..   .|.| ..||. . .  . |||.||||||| ||||.|... ||.| .|  |   ||... .  ||. ||..||. ||| |.. |.|| 
gwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel

L
|
l

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 314-582 9.5e-88 289.0 In-house 10-278 (288) alignment
Range on Protein: 314-582
Range on HMM: 10-278/288.0
EYVAKMQANGGIRLENEYKKF-NNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWR
..|||..|..   ...||..  . ...   .|.|.. |..|||| ||..||. || |. ..  ...||||||.|.|.... . .||.||||. . . ||.
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkk.kkyiatqgPladtvndfWe

MVWEQNSQSIVMLTNLVELGKTKCHKYWPDKIE--TYGGVTVTLHQSEIFADYEIRTFILSkaKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRA
.|.|.... |||||.||| |||||..||||. .   || ||||| .|.   |.  |...|   |. . . . |.....|||.|||. .. .|...|.|  
lvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkv

LNPRDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
 |. |.||.|||||||| ||||.|..||.... ... ..|. . .  ||| |. .|||..|| ||....|. 
anqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsl

subfamily_Ptp69D_pd Subfamily Ptp69D 310-603 1.8e-85 281.8 In-house 7-306 (307) alignment
Range on Protein: 310-603
Range on HMM: 7-306/307.0
ALFPEYVAKMQANGGIRLENEYKKFN-NGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLPPAFE
   .| . . . .    |..||.| . .  .   ... |  |. |||| .|.|.|. ||.|...||.|||||||||||.||. . ..|||.|.|.    .
ddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykek.kkfiaaqdPveatig

GFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP-DKIETYGGVTVTLHQSEIFADYEIRTFILSKAKRSG-----SRMVRQFHFTVWPDKGVPQYATAVL
 ||||..||... ||||.|| |  . ||.|||| ...  || . |.| ..|   || ||.. .|| | ..     || | |.|.| |.|  ||. |...|
DfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargll

AFRRKVRALNPRDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSETYNQAMQKL
 . ..|| |.  . .|..|||||||.|.|... .| .|.| |.  .||| .    ||..|. .||  |||.|.. |.|.  . |.|... .....|...|
klieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledaierl

A
.
c

DSPc_SM00195 328-583 1.9e-85 281.7 In-house 3-262 (263) alignment
Range on Protein: 328-583
Range on HMM: 3-262/263.0
ENEYKKFNNGQ-QFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYdGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLT
..|..| .. . . . . |.|..||.|||| ||. |||.|| |.. ...|.||||||..| |.   ....|| |||||  .| |||||||.... |||||
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NLVELGKTKCHKYWPDKI---ETYGGVTVTLHQSEIFA-DYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVH
. .| ||.||..|||...   ||.| ..|.| . |.   ....||. |.| ... .| |.|.... |||.|||. .. ||.. |.|.  . .  ||..||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
|||||.||||...|| .|.. ..  .||| . . .||| ||.||||.|||.||. |.||..
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 328-583 1.9e-85 281.7 In-house 3-262 (263) alignment
Range on Protein: 328-583
Range on HMM: 3-262/263.0
ENEYKKFNNGQ-QFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYdGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLT
..|..| .. . . . . |.|..||.|||| ||. |||.|| |.. ...|.||||||..| |.   ....|| |||||  .| |||||||.... |||||
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NLVELGKTKCHKYWPDKI---ETYGGVTVTLHQSEIFA-DYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVH
. .| ||.||..|||...   ||.| ..|.| . |.   ....||. |.| ... .| |.|.... |||.|||. .. ||.. |.|.  . .  ||..||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
|||||.||||...|| .|.. ..  .||| . . .||| ||.||||.|||.||. |.||..
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

0050432 (Phosphotyrosine protein) phosphatases II 578-882 3.3e-83 274.9 In-house 7-305 (308) alignment
Range on Protein: 578-882
Range on HMM: 7-305/308.0
AVLEALTCGNTEIQSETYNQAMQKLAS-VNRKFQMTGYALEFQRLNSVTSreipAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLhnehaDEESDYINAV
|.||.|....|.|. ..... ...|.  ..........  ||..|.||.      .| ||.. |.| .|||..||... ..|| |     ||.|||||| 
allelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkp....lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAs

FLHAH--RGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELD-QEYPQYWPDH---GATKYGHIGVSVLSKQEKGDVICTKLKVTRKKVRrKT
. . .  . ...|||||.|| .||||||||| .... .||||..|.| . . ..||||.    | ..||.. | .|| ....|.....|..| ..   ..
yvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg.es

QEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQqqcGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQ
 .| |.|. .||| ..|. . ..||.|.....|.   .. |..| ||.||||.|||.|.  .||.|..|. .|||...|..|   ||.|..| ||||.|.
rtvthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyr

IIQKYFDSFSDY
....|. ..  .
alleylklkltk

0040439 (Phosphotyrosine protein) phosphatases II 341-583 1.7e-82 272.1 In-house 2-246 (249) alignment
Range on Protein: 341-583
Range on HMM: 2-246/249.0
PWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYW
... |..|.||.|||| .|..||||||.|. ..| ..|||||||.|.||. ..| ||| ||||| ..| ||||.||.....|||||.|||||. ||..||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr.fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqyw

P-DKIETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR--DAGPVIVHCSAGVERTGTYIVID
| ..  .||..|||| . |...|| .||. |.. . . ||.|.....| ||| |||..   .|.| ..||  . .  . |||.||||||| ||||.|...
plggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaay

AMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
 |||| .| ..||. ...  ||. ||..||. ||| |.. |.|| |
lmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 344-602 8.6e-82 270.0 In-house 55-310 (319) alignment
Range on Protein: 344-602
Range on HMM: 55-310/319.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTnlvelgKTKCHKYWPDK
 |  . ||.|||. ||.|.|...| |||..| | ||||||||. ||   .  .||.||||. . . ||||.||.|. .||.||      | || .||| |
fanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyq.rkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplk

I-ETYGGVTVTLHQSEIFADYEIRTFILSK-AKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAG--PVIVHCSAGVERTGTYIVIDAM
| ....   | ..  |  |.| .| . ||. .|  . | ..||||  |||.|||.|.. .. . .||| |. .  .  ...||||||| |||.|||.|..
ivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvl

LEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSETYNQAMQKL
|.. |. . ||. |..  ||..|...||   || ||.||.||    |....    .   ...|
ldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleel

Y_phosphatase Protein-tyrosine phosphatase 350-581 1.2e-81 269.0 Pfam-A 1-235 (235) alignment
Range on Protein: 350-581
Range on HMM: 1-235/235.0
NKNKNRYANIVAYDHSRVVLervNGDED-SDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP---DKIE
||.|||| .|..||..|| |   .|.|. ||||||....||. ....|||.||||.  .| ||||||......|||||.|.| |..||..|||   .. .
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

TYGGVTVTLH-QSE-IFADYEIRTFILSKAKRS-GSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVERTGTYIVIDAMLEQ
||| ..|.|  ... . ..| .|.. |.| |..  .|.|.|.|.| |||.|||. ....| . |||.  .  . |||.|||||||.||||....|..|||
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

AKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
... ..||. ...  ||| ||.|||. ||| |.. |.||
leaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

Y_phosphatase Protein-tyrosine phosphatase 350-581 1.2e-81 269.0 In-house 1-235 (235) alignment
Range on Protein: 350-581
Range on HMM: 1-235/235.0
NKNKNRYANIVAYDHSRVVLervNGDED-SDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP---DKIE
||.|||| .|..||..|| |   .|.|. ||||||....||. ....|||.||||.  .| ||||||......|||||.|.| |..||..|||   .. .
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

TYGGVTVTLH-QSE-IFADYEIRTFILSKAKRS-GSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVERTGTYIVIDAMLEQ
||| ..|.|  ... . ..| .|.. |.| |..  .|.|.|.|.| |||.|||. ....| . |||.  .  . |||.|||||||.||||....|..|||
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

AKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
... ..||. ...  ||| ||.|||. ||| |.. |.||
leaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 306-627 2.5e-81 268.3 In-house 1-320 (515) alignment
Range on Protein: 306-627
Range on HMM: 1-320/515.0
PIPIALFPEYVAKMQANggIRLENEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGtPRSFIASQGPLPP
|.|.| || .|.| .      . .|.. .   . .|   |..  | .|||| ||. || .|| || .| . .|||.|||.|...|   ...||||||.. 
plplaqfPafvnknrht..tlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdn.dkayiasqgPnka

AFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK---IETYGGVTVTLHQSEIFADYEIRTFILSKAKRsgSRMVRQFHFTVWPDKGVPQYATAVL
. . |||.|...|   |.|.|.| |  | || ||||||      .| . | |   |  ..  .|.. . | .   || | ||||| |||||||. ....|
svddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssll

AFRRKVRALNPRDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSETYNQAMQKL
 . ..|.| . . . |.|.|||||| ||| .| || .. .||..|.||. |..  .|..||..|||.|||.||. |||| |   || |    . . .| |
klikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdl

ASVNRKFQMTGYALEFQRLNSVTSR
 |       .  . ||| |.|..  
hssgdgrgrskmtkefqtlkslcpd

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 305-605 4.1e-81 267.3 In-house 1-299 (315) alignment
Range on Protein: 305-605
Range on HMM: 1-299/315.0
KPIPIALFPEYVAKMQANggIRLENEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGtPRSFIASQGPLP
.|||.| || .| | .      . .|.. . . . ..  .||.. | .|||| ||. .|..||.|| .. . ||||||||.|...|   ...|||||||.
qpipvaqfpafvnknrht..alfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdd.dkayiasqgPlk

PAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPD---KIETYGGVTVTLHQSEIFADYEIRTFILSKAKRsgSRMVRQFHFTVWPDKGVPQYATAV
 . . |||||....  .|||.|.. |  | || .||||   .   .| . |.| . |  .|  .| ... |..   || | ||.|| ||||||.. ....
asvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrksee..srtvtqfqftewPdkGvdkqtssl

LAFRRKVRALNPRDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSETYNQAMQK
| . ..|.| | ..  ...||||||| |||  | || ...|.|..|.||. |..  ||..||..|||.|.|.||. |||| |   || |    . . .| 
lklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqd

LASV
| . 
lhts

0051299 (Phosphotyrosine protein) phosphatases II 586-876 1.2e-80 266.3 In-house 1-286 (288) alignment
Range on Protein: 586-876
Range on HMM: 1-286/288.0
GNTEIQSETYNQAMQKLAsvnrKFQMTGYALEFQRLNSVTSReipaEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRN
|.|||. | . ....||     . ..||.. ||..| |..       . |..  |.||.|||.|||......|| |.... .|.|||||| ... ..  .
gdteisveellklvlkll....angltglleefeellsllpd....ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkr

AFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELD-QEYPQYWPDHGATKYGHIGVSVLSKQEKGDVICTKLKVTRKK---VRRKTQEVCHLHHVSW
.|||||.|| .||||||||| .... .||||..|.||. . ..||||..| ..||.| |  || ....|.....|.||...      ....| |.|. .|
kfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnw

PDKCIPELACSVLDLLDEAQTSQQqCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYF
|| ..|. . ..||.| .......  |. ||.| ||.||||.|||.|.  .||.|..|...||....||.|   ||.|..| ||.|.|...  |.
pdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 346-603 1.5e-80 265.7 In-house 21-275 (284) alignment
Range on Protein: 346-603
Range on HMM: 21-275/284.0
RKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTnlvelgKTKCHKYWPDKI-
  . ||.|||. .|.|.|...| |||. | | ||||||||| ||   .  .||.||||. . . ||||.||.|. .||.||      | || .||| || 
nldqnkdknrighilafdknvvklerliGeefsdyinasfitGyq.rkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkiv

ETYGGVTVTLHQSEIFADYEIRTFILSK-AKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAG--PVIVHCSAGVERTGTYIVIDAMLE
....   | ..  |  ..| .| . ||. .|  . | .|||||  |||.|||.|.. .... .||| |. .  .  ...||||||| |||.|||.|..|.
ikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlld

QAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSETYNQAMQKLA
. |. . ||. |..  ||..|...||   || ||.||.||    |....    .   ...|.
rmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleels

0042113 (Phosphotyrosine protein) phosphatases II 343-582 2.4e-80 264.7 In-house 2-242 (245) alignment
Range on Protein: 343-582
Range on HMM: 2-242/245.0
EAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP-
. |..|.||.|||| .|..|||.||.|  ..||.||||||||...||. ||. |||.|||||  .| ||||.||.....|||||...|||. ||..||| 
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpk.fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl

DKIETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNP-RDAGPVIVHCSAGVERTGTYIVIDAML
. . |||..||||   |...|| .||. ... . . ||.|...|.. ||| ||| .   .| | . ||      . |||.||||||| ||||.|... ||
gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylml

EQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
||..| ..|.. . .  ||. ||..||| .|| |.. |.|| 
eqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel

subfamily_PTPN12_pd Subfamily PTPN12 326-583 2e-79 261.5 In-house 16-277 (290) alignment
Range on Protein: 326-583
Range on HMM: 16-277/290.0
RLENEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMVWEQNSQSIVML
.| .. .|. . .... ||..|. |..|||| .|. ||.|||.|.. ...|.||||||.||.| .|.  ..||.||||| . . ||||.||.| . .||.
klkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegk.leyiaaqgPLpktlddfWrmiweknveivvma

TNLVELGKTKCHKYWPDKIE---TYGGVTVTLHQSEIFA-DYEIRTFILSKAkrSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIV
 ..|||||.||..|||.. |   ..| ..|||.. . .  |. |||. . .   . ||.|.|||.| |||.|||. |. .|.. ..|| |. ... |..|
CrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvv

HCSAGVERTGTYIVIDAMLEQ---AKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
|||||| |||| |.|| . |.    | . ..|. . .. |||.|. .|||||||.... ||.| .
hCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv

subfamily_PTPN6_pd Subfamily PTPN6 329-582 2.5e-79 261.5 In-house 30-296 (306) alignment
Range on Protein: 329-582
Range on HMM: 30-296/306.0
NEYKKF---NNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLErVNGDEDSDYINASFIH-GYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVM
.|....   .. ...  . ..|| ||.|||| ||. .||.||.|.  ..  .||||||..|.    |. .|.||.|| |.   . ||||||..||. |||
eefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivm

LTNLVELGKTKCHKYWPDKIE--TYGGVTVTLHQSEIFADYEIRTFILSK-AKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRA----LNPRDAG
.|. || || || .||||. |  .|| ..||  ...  |||..|.. .||  | . .| |.|.||..|||.|||.   |||.| ..|..    |. ..||
ttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeag

PVIVHCSAGVERTGTYIVIDAMLEQAKKS---RTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
|..||||||. ||||.||||..|.. .|.     .||..    .|. |  .|||..|| |.. |. . 
pivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikky

0045098 (Phosphotyrosine protein) phosphatases II 336-586 2.4e-78 258.6 In-house 19-275 (278) alignment
Range on Protein: 336-586
Range on HMM: 19-275/278.0
NGQQFPWEAARKPANKNKNRYANIVAYDHSRVVlervngdedsDYINASFIHGYdgtPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTK
 |.   .. | .. |..|||| .|..||||||.          ||||||.|.||   |. ||| |||||  .. ||||.||.....|||||.|||||. |
lgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy...pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrek

CHKYWPDKI-ETYGGVTVTLHQSEIFADYEIRTFILSKA----KRSGSRMVRQFHFTVWPDKGVPQYA--TAVLAFRRKVRALNPR-------------D
|..|||..  .|||..|||| . |.. || .||...       .   || |...|.. ||| ||| .   . .| . . .|. . .             .
caqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssllllds

AGPVIVHCSAGVERTGTYIVIDAMLEQAkkSRTVDIRNYLIALRKDRPH-MVQTKEQYSFIHSAVLEALTCG
 |||.||||||| ||||..... |||.    ..||. ...  ||. ||. .||..||| |.. ..|| | .|
ggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 613-886 9.5e-78 256.4 In-house 21-290 (318) alignment
Range on Protein: 613-886
Range on HMM: 21-290/318.0
GYALEFQRLNSVtsREIPAEEKSvgEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGT
 .  |..||. .  .| ... ||   || | .|||. .|.| ...|| |.. . .|.|||||| ..  .| ..|.||.| || ||.||||||| . .  .
llseeyerlsrs..eetvtslks..lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsav

IVMLNNLHELDQ-EYPQYWPDHGATKYGHIGVSVLSKQEKGDVICTKLKVTRKKVRrKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQCGNAP
|||| ...|  .    .|||..|...||.. | . .. | .| .  ..||||...  ....|   |. ||||. .|| ..|.|||. .... ||..|. |
ivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteee.esrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagp

VLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFDSFSDYANYS
..| || |||| |.|.|....|||.| |...||||..|..| . .  |    || |.|......  |.  ... |
ivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdas

0046845 (Phosphotyrosine protein) phosphatases II 616-882 1.1e-77 256.6 In-house 4-280 (284) alignment
Range on Protein: 616-882
Range on HMM: 4-280/284.0
LEFQRLNSVTSREIpaEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHAD-EESDYINAVFLHAH-----RGRNAFIATQHPLLETVEDFWRMVTDYD
 ||..|.|.|   .   . ||.  |.||.|||..||......|| |.... | |.|||||| ... .     . ...|||||.|| .||||||||| ...
eefeellsltvkll..lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

IGTIVMLNNLHELDQ-EYPQYWPDHG-ATKYGHIGVSVLSKQEKGDVICTKLKVTRKKVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQ-
. .||||..|.| ..  ..||||. |   .||.. | .||...|.|.....|..|....  .. .| |.|. |||| ..|. . ..|..|......... 
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

CGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQ---VIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFDSFSDY
 |. |..| ||.||||.|||.|.  .||.|..|.   ..||....||.|   ||.|... ||.|.|.... |. ..  .
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltl

0037934 (Phosphotyrosine protein) phosphatases II 342-581 2.3e-76 251.8 In-house 2-240 (243) alignment
Range on Protein: 342-581
Range on HMM: 2-240/243.0
WEAARKPANKNKNRYANIVAYDHSRVVLervngdEDSDYINASFIHGYDgtpRsFIASQGPLPPAFEG----FWRMVWEQNSQSIVMLTNLVELGKTKCH
.  |..|.|..|||| .|..||||||.|      |.||||||..| ...   | .||.|||||  .|     ||||.||.....|||||.|||||. ||.
fsiallpenlsknrysdilpydhsrvkl......egsdyinanliyvtp...r.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekca

KYWPDKIeTYGGVTVTLHQSEIFADYEIRTFILSKAK-RSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRAL--------NPRDAGPVIVHCSAGVE
.|||... |||..|||| ..| ..|| .||. |.  .    .|.|...|.. ||| |||.  . .|.| ..||.         .  . |||.||||||| 
qywpgev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvg

RTGTYIVIDAMLEQAkksrTVDIRNYLIALRKDRPH-MVQTKEQYSFIHSAVLE
||||.|... ||..     .||. ...  ||. ||. .||| .|| |.. |.||
RtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 612-880 1.2e-75 249.6 In-house 23-287 (319) alignment
Range on Protein: 612-880
Range on HMM: 23-287/319.0
TGYALEFQRLNSVTSReipaeEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIG
|. . ||. |.  ..      . .  ....| .|||...|.| . .||.| . .  |.|||||| |. ... |..||||| || .|.||||||| .... 
tllekefkllkeavnd.....tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeess

TIVMLNNLHE-LDQEYPQYWPDHGATKYGHIGVSVLSKQEKGDVICTKLKVTRKKVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQCGNA
..|||..| | |. .. .|||..  ..||.. | .....|. |.|  |||. .|.   .| || | .. .|||. .|| | |.|||| . . |...  . 
ivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsg

PVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFDSFS
|. | ||.|||| |||.... .|||.| |.|.|||....|.|.  .  |. | || |.|... .. ....
PivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 305-595 1.9e-75 248.8 In-house 8-296 (297) alignment
Range on Protein: 305-595
Range on HMM: 8-296/297.0
KPIPIALFPEYVAKMQANGgiRLENEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGtprSFIASQGPLP
.|||.. |. .| | .       ..|..   . . .|   |.|  | .|.||.||. || ||| |. || | ||||.||||..|.      .|..| | .
rpiplsdfatlvqknrhtd..vfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh...rlittqmPmk

PAFEGFWRMVWEQNSQSIVMLTNLVELGKtKCHKYWPDK-IETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQ--YATAV
 . . ||.||.... . ||||... |  | || .||.|| . |.| |.|.|.  .    .  |.. ..| |    |.|.|..|. |||| |..   |...
atvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassl

LAFRRKVRALNPRDAG-PVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSETY
| .   ||      |  |..|||.||| ||| .. || .. .||.  .||| ...  ||..||..|||||||.|.. |||||| . .|.||.. .
lklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqasyf

subfamily_PTPN9_pd Subfamily PTPN9 312-581 3.7e-75 247.7 In-house 6-288 (297) alignment
Range on Protein: 312-581
Range on HMM: 6-288/297.0
FPEYVAKMQANGgirLENEYKKFNNGQ-QFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPAFEGF
. .|| ... .|   | .||..  | . .   .|....|| .||||.... ||..||||..|..|| ||||||.|. ||   ...||| ||||. ... |
lvayvkekgkrG...lskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGyk.qkkafiatqGplkktvsdf

WRMVWEQNSQSIVMLTNLVELGKTKCHKYWP---DKIETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRK
|||||||.   ||| | .|| |. || .|||   .. . .| ..|.  . |   ||..|.. ....| . || |  | |. ||| |||. |...| ...|
WrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlek

VRA--------LNPRDA-----GPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
||         | ....      |..||||||. ||||.| .|  |.. ..  |||... .  ||. | ...|| ||| | . ||||
vrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle

0040438 (Phosphotyrosine protein) phosphatases II 609-877 5.1e-75 248.0 In-house 15-277 (317) alignment
Range on Protein: 609-877
Range on HMM: 15-277/317.0
FQMTGYALEFQRLNSVtsreiPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDY
 ..|.   ||..| |.     . .. ||.| |.| .|||..||. . ..|| |...  |..|||||| . . .. ...|||||.|| .||||||||| ..
sdftalleefedllsl.....kldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweq

DIGTIVMLNNLHELD-QEYPQYWPDHGATKYGHIGVSVLSKQEKGDVICTKLKVTRKkVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQqC
....||||..| ||. . . ||||. . ..||.. | .|| .|..... ..|.|. .    .. .| |.|. .||| ..|.   ..||.|........  
gvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavreale.d

GNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFD
.. |||| ||.||||.|||.|.  .||.|..|. .||....|..|   ||||..| || |.|.....|. 
pggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylk

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 314-609 6.6e-75 247.2 In-house 12-314 (325) alignment
Range on Protein: 314-609
Range on HMM: 12-314/325.0
EYVAKMQANGGIRLENEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRM
|.| | .|.    . .|..   . .    ..| ||.||.|||. |.||.|.||||||  . | .|||||||... . .    |.|.| ||. . . .||.
ehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkk.dvflaaqaPltatindlWrl

V--WEqnsQSIVMLTNLVELGKTKCHKYWPDK---IETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKV
|  |.    |.|...| ..||| .| .|||..     |.||. | |   | ..||  | . . ..|.  .| |.||..  |.| ||... ...... . |
vldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlv

RAL------NPRDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSETYNQAMQKL
 |.      | . ..|..||||||| |||..| . ..|..  .   ||| ...  |||||| ||.| .||..|. |. ||. .|||..   ...  .  |
kavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklssl

ASVNRKF
   |   
qernplt

0039614 (Phosphotyrosine protein) phosphatases II 602-879 9.3e-75 247.1 In-house 22-292 (297) alignment
Range on Protein: 602-879
Range on HMM: 22-292/297.0
LASVNRKFQMTGYALEFQRLNSVTSreipaEeKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHA-DEESDYINAVFLHAHRG-RNAFIATQHPLLETVE
|  .......|.. |||..| |..      . .|... |.| .|||..||......|| |. |   |..|||||| ..  ..   ..|||||.|| ||||
llllekansktllllefeellslkp.....d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetve

DFWRMVTDYDIGTIVMLNNLHELDQEYPQYWPDHGAtKYGHIGVSVLSKQEKGDVICTKLKVTRkkvRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDE
|||||| .... .||||..| ||.. ..||||. |  .||.. | .|. ....... ..|.||.     .. .| |.....||| ..|... ..|..|..
dFwrmvweqgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtlevtn...ngesrtvthfqytgwpdhgvppslellleflel

AQTSQQQC-GNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFDSF
... .... .. |||| ||.||||.|||.|.  .||.|..|. .||....|..|   ||||..| || |.|.......  .
vrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk

0047943 (Phosphotyrosine protein) phosphatases II 605-876 1.2e-74 246.6 In-house 5-272 (273) alignment
Range on Protein: 605-876
Range on HMM: 5-272/273.0
VNRKFQMTGYALEFQRLNSVTSreipAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLhnehADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRM
.......|....||..| |..       ..||.. |.|..|||..||......|| |     |..|||||| ..  ..  ..|||||.|| .||||||||
lekllgltllleefelllslkp....lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrm

VTDYDIGTIVMLNNLHELDQ-EYPQYWPDHG---ATKYGHIGVSVLSKQEKGDVICTKLKVTRKKVRRkTQEVCHLHHVSWPDKCIPELACSVLDLLDEA
| .... .||||..|.||..  ..||||. |    ..||.. | .|| ..|.|.. ..|..|...    . .|.|.|. .||| ..|.   |.|......
vweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielv

QTSQQQC-GNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYF
.. .... .| ||.| ||.||||.|||.|.  .|..|..|. .||....|..|   ||.|..| ||.|.|... .|.
rkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

0036941 (Phosphotyrosine protein) phosphatases II 604-878 1.3e-74 246.5 In-house 5-279 (297) alignment
Range on Protein: 604-878
Range on HMM: 5-279/297.0
SVNRKFQMTGYALEFQRLnsvtSREIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLhnehADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWR
 ..........  ||..|     . ..  ..||.. |.||.|||..||......|| |     ||.|||||| ..  ..  ..|||||.|| .|||||||
llekllflalllkefeel....lpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWr

MVTDYDIGTIVMLNNLHELDQ-EYPQYWPDH--GATKYGHIGVSVLSKQE--KGDVICTKLKVTRKKVRrKTQEVCHLHHVSWPDKCIPELACSVLDLLD
|| .... .||||..| ||.   ..||||.   .  .||.. | .|| ..  ..|.. ..|.|| ..   .. .| |.|. .||| ..|| . |.||...
mvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgng.esrtvthfhytgwpdhgvpespaslldfie

EAQTSQQQC-GNAPVLVQCSNGVGRSGTFCAISSVLERLK---TEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFDS
.... ...  .. |||| ||.||||||||.|.  .|..|.   .|. .|.....| .|   ||||... ||.|.|....... .
lvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkk

0045450 (Phosphotyrosine protein) phosphatases II 610-876 2.1e-72 239.8 In-house 25-304 (307) alignment
Range on Protein: 610-876
Range on HMM: 25-304/307.0
QMTGYALEFQRLNSVTSREipAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHAD-EESDYINAVFL--------HAHRGRNAFIATQHPLLETVED
 .||.. ||..|.||| .     | |... |.| .|||..||......|| |.... . |.|||||| .         . ..  ..|||||.|| |||||
fltgllkefekllsvtvfl..lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetved

FWRMVTDYDIGTIVMLNNLHELDQE-YPQYWPDHGAT-KYGHIGVSVLSKQEKGDVICTKLKVTRKKVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLD
||||. ......||||..| ||..| ..||||| | .  ||.. | .||...........|.||...   .. .|.|.|. .||| ..|.   ..||...
FwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfie

EAQTSQQQC-GNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQV---IDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYF
|... .... .. |||| || ||||.|||.|.  .|..|..|..   .|.....|..|   ||||..| || |.|.......
evrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell

subfamily_PTPRA_pd Subfamily PTPRA 621-876 3.4e-72 238.1 In-house 38-295 (330) alignment
Range on Protein: 621-876
Range on HMM: 38-295/330.0
LNSVTSREIPAEEKSVgEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLH
.|.. . .| |  .   .. .| .|||. .|.  .  ||.| . .  |||||||| |.. .. .. |||.| |. |||||||||. ...  ||||| .|.
fnalPagpiqatlela.skeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelk

ELDQEY-PQYWPDHGATKYGHIGVSVLSKQEKGDVICTKLKVTR---KKVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQCGNaPVLVQC
| ..|   |||||.|.  ||.| |.|  ...  |.   |. |..   .. ..|.. |  .|  ||||  .|  .  .|.|| . .. .|| .. |. | |
erkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhc

SNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYF
| ||||.|||.....||||.|.|...|||...||.| . |  | .  || |.|.....|.
saGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 631-879 3.4e-72 238.2 In-house 35-286 (305) alignment
Range on Protein: 631-879
Range on HMM: 35-286/305.0
AEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQEY-PQY
 |   ||.. .| .|||...|. |.  |..| ... ...|||||| ...........|..| || .||.||||.. .. . ||||| .| | ...   ||
eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqY

WPDHGAT--KYGHIGVSVLSKQEKGDVICTKLKVTRKKVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQCGNAPVLVQCSNGVGRSGTFC
||.  .   ..|.. | . |...  | |  |||.. ..  .... | ...  .|||. .|. | |.|.|... | .|..  . |.|| ||.||||.|.|.
WpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfi

AISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFDSF
|..  |||||.|.|.|||.|.|..| . ...|..  || |........  ..
avdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 341-581 1.1e-71 236.1 In-house 19-266 (274) alignment
Range on Protein: 341-581
Range on HMM: 19-266/274.0
PWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDE-DSDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKY
. |  . . ...|||| .|.  ..|||.||. .... ||.|||| .|.|||.. . ..| ||||| . . ||||......| |||||.| |  ..||..|
dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavy

WPDKIET-----YGGVTVTLHQSEIFADYEIRTFILSKAKRsgSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR---DAGPVIVHCSAGVERTG
.||....     ||.| .. ..     ||..|...|....|  .| |  . .| |||. .|. |...| . ..|.  . .    ..||.||||||. |||
fPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtG

TYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
 .| |.  . | ... .||. .    || ||  ||||.||| .|| |. .
cfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 307-587 1.7e-71 235.4 In-house 2-287 (290) alignment
Range on Protein: 307-587
Range on HMM: 2-287/290.0
IPIALFPEYVAKMQANGGIRLENEYKKFNNGQ-QFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDED--SDYINASFIHGYDGTpRSFIASQGPL
||.  | |.||. .|.|  . .|..|....|. ..  . .  . ||..||.|||| ||  |..| ...|..|   .||||..|.||    ...|| |||.
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykek.kqyiatqgpv

PPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK-IETYGGVTVTLHQSEIFADYEIRTFILSKAKR-SGSRMVRQFHFTVWPDKG-VPQYATA
.     ||...|....  |||||| .| ||.||..||||.  ..|| ....|.. |.. .| .|.. . . .    ...| |...| |...| |....| 
sntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqti

VLAFRRKVRALNPRDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGN
.|.... ..    |  ....||||..| |........  ....|.   .|. . |  .|  .| .|||..|| .|.. ||..|.. .
llvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfe

DSPc_SM00195 617-876 3.4e-71 235.0 In-house 5-262 (263) alignment
Range on Protein: 617-876
Range on HMM: 5-262/263.0
EFQRLNSVTSREipaeEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVML
||..|.. || .    |.. .|...| .|||...|.  .. || |..|. .|.|||||| ..  .. ....||||.|| .|||||||||.. .. .||||
efekleestspk....etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

NNLHEL-DQEYPQYWPDH--GATKYGHIGVSVLSKQEKG-DVICTKLKVTRKKVrRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQCgNAPV
..  |   ..  .|||.   | ...|.| | . ....|  ..| ..|..| ..  ..|..| .... .|||. .|. . |||.|| ....|...  ..|.
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpi

LVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYF
.|.||.||||.|||..|...|..|..|. .|.|...|..| . ||.|.. .||||.|..| .|.
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 617-876 3.4e-71 235.0 In-house 5-262 (263) alignment
Range on Protein: 617-876
Range on HMM: 5-262/263.0
EFQRLNSVTSREipaeEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVML
||..|.. || .    |.. .|...| .|||...|.  .. || |..|. .|.|||||| ..  .. ....||||.|| .|||||||||.. .. .||||
efekleestspk....etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

NNLHEL-DQEYPQYWPDH--GATKYGHIGVSVLSKQEKG-DVICTKLKVTRKKVrRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQCgNAPV
..  |   ..  .|||.   | ...|.| | . ....|  ..| ..|..| ..  ..|..| .... .|||. .|. . |||.|| ....|...  ..|.
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpi

LVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYF
.|.||.||||.|||..|...|..|..|. .|.|...|..| . ||.|.. .||||.|..| .|.
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 307-590 8.1e-71 233.3 In-house 2-285 (287) alignment
Range on Protein: 307-590
Range on HMM: 2-285/287.0
IPIALFPEYVAKMQANGGIRLENEYKKFNNGQQFPWEAARK--PANKNKNRYANIVAYDHSRVVLErvngDEDSDYINASFIHGYDGTpRSFIASQGPLP
||.  | |.||| .|.|    .| .. ... .| . |   .  . ||.|||...|. .|  ||.|.    .|. |||||.|| ||    . ||....|. 
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykek.kafiiaesPmf

PAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKI-ETYGGVTVTLHQSEIFADYEIRTFILSKAK-RSGSRMVRQFHFTVWPDKG-VPQYATAV
 .   ||......| . ||||... |  . .|..|||..   ..|  ...| . |. |.| .|.. . . .  .  ..|.|...| |...| |....| .
ntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtil

LAFRRKVRALNPRDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEI
| . .....   |  ....||||..| |..... ..  ....|.  ..|. . |   |  .|..||| ||| ||  .||| |....|  
lvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetys

0043336 (Phosphotyrosine protein) phosphatases II 607-876 9.1e-71 233.9 In-house 15-277 (278) alignment
Range on Protein: 607-876
Range on HMM: 15-277/278.0
RKFQMTGYALEFQRLNSVTSreipaEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVT
 .   |.. |||..|.|..      ...|... |.| .|||..||......|| |...  |. |||||| ..  ..  ..|||||.|| |||||||||| 
llnlktllllefeellsfkl.....dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvw

DYDIGTIVMLNNLHELD-QEYPQYWPdHGATKYGHIGVSVLSKQEKGDVICTKLKVTRkKVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQ
.... |||||..| ||. . . ||||  | ..||.. | .|. ....|.. ..|.||. .   ....|.|.|...||| ..||   ..||.| .... ..
elgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtn.lgdgesrtvthyhylgwpdhgvpeslsllldflkavreale

qCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYF
   | |||| ||.||||.|||.|.  .||.|..|. .|.....|..|   ||||..| || |.|.... |.
.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl

subfamily_PTPN3_pd Subfamily PTPN3 339-582 2e-69 228.6 In-house 30-274 (280) alignment
Range on Protein: 339-582
Range on HMM: 30-274/280.0
QFPWEAARKPANKNKNRYANIVAYDHSRVVLErvngDEDSDYINASFIHG-YDG--TPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTK
.   .|||||.| .|||| .|..||. || |.    ....|||||...    ..  .   .||.||||. . . ||.|||||.|. |||||.||| |..|
glaisaarkpenlsknryrdilpydatrvklk....esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvk

CHKYWPDKIE--TYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVERTGTY
||.|||.. .  .||. .|......    | .| ..|.... . .|.. |. .. |||.|||. .. .| | ..||.|   .  ||.||||||..||| .
ChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvl

IVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
|...  |    ... | . . .  .|  |  .|||..|| |.  |.|..
illetalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 305-606 2.2e-69 228.8 In-house 2-259 (392) alignment
Range on Protein: 305-606
Range on HMM: 2-259/392.0
KPIPIALFPEYVAKMQANggIRLENEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLP
.|||.| || .| | . .    . .|.. . . . .|  .|.|. |..|||| ||. || .||.|| ..   ||||.|||.|...|   ...|||||| .
qpipvaqfpafveknrhs..alffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdne.kayiasqgpna

PAFEGFWRMVWEQNSQSIVMLTNLVELGktkchkywpdkietyggvtvtlhqseifadyeirtfilskaKRSGSRMVRQFHFTVWPDKGVPQYATAVLAF
 ... |||||...|  .|.|.|.| |                                           |    | | ||||| ||||.||......| |
aslddfwrmvfqenvttiamvtklkegd.........................................kgddartvaqfhftewPdkdvpkhtssllkf

RRKVRALNPRDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSETYNQAMQKLAS
 ..|.|   . . |.|.|||||| |||  | ||... .|||.| ||. |..  .|. ||.||||||||.||. |||| |   || |    . . .|.| .
ikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlst

VN
  
ss

subfamily_PTPN1_pd Subfamily PTPN1 335-590 4.4e-69 227.4 In-house 17-280 (290) alignment
Range on Protein: 335-590
Range on HMM: 17-280/290.0
NNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERvngdEDSDYINASFIHgYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKT
.. ..|| ..|..|.|.|.||| ..  |||||..|||    .| ||||||...  .   ||.| .||||| . . ||.|||||.|...||| ..|| ...
keasdfptreaklpenrnlnryrdvspydhsrikler....adndyinaslve.leeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqi

KCHKYWPDKIE----TY--GGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRAL--NPRDAGPVIVHCSAG
||..||| . |    ..    ..|.| . |.   | .|.. | . |   .| . .||.| ||| |||.  .| | |  |||      .| ||...|||||
kcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaG

VERTGTYIVIDAMLEQAKKSR---TVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTC--GNTEI
. |.||....|..| . .|.    .|||.. |..||| |  ..||..|  | . |.||   .  |.. .
iGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdssv

Y_phosphatase Protein-tyrosine phosphatase 642-873 5.8e-69 227.5 Pfam-A 1-234 (235) alignment
Range on Protein: 642-873
Range on HMM: 1-234/235.0
NLHKNRFSDIIALNSCRVMLhnEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHEL-DQEYPQYWP--DHGATKY
|..|||..||.. .. || |  .. ...|||||| ... ..  ..|||||.|| .|.|||||||..... .||||..| |  .....||||  ... ..|
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GHIGVSVL--SKQEKGDVICTKLKVTRKKVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQqQCGNAPVLVQCSNGVGRSGTFCAISSVLERL
|.| | .   .|... ... .||... || .....|| .||. .|||...|| . |.|||... ..|. .  ..||.|.||.||||.|||.|.. .||.|
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

KTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQ
..|. .||.|..|..| . ||.|.| .|| |.|..|.
eaeeevdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 642-873 5.8e-69 227.5 In-house 1-234 (235) alignment
Range on Protein: 642-873
Range on HMM: 1-234/235.0
NLHKNRFSDIIALNSCRVMLhnEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHEL-DQEYPQYWP--DHGATKY
|..|||..||.. .. || |  .. ...|||||| ... ..  ..|||||.|| .|.|||||||..... .||||..| |  .....||||  ... ..|
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GHIGVSVL--SKQEKGDVICTKLKVTRKKVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQqQCGNAPVLVQCSNGVGRSGTFCAISSVLERL
|.| | .   .|... ... .||... || .....|| .||. .|||...|| . |.|||... ..|. .  ..||.|.||.||||.|||.|.. .||.|
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

KTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQ
..|. .||.|..|..| . ||.|.| .|| |.|..|.
eaeeevdvlqivkelRkqRpgmvqsleqYiflykail

subfamily_Ptp69D_pd Subfamily Ptp69D 612-877 1.4e-67 223.0 In-house 22-287 (307) alignment
Range on Protein: 612-877
Range on HMM: 22-287/307.0
TGYALEFQRLNSVtsrEIPaEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIG
 |.| |...|..    ||.  . .|.|.  |. |||. ||.| .. ||.|..   .|.|||||| |..... .. ||| | |. .|..|||||... .. 
fglakeyekLear...eid.kstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevt

TIVMLNNLHELDQE-YPQYWPDHGATKYGHIGVSVLSKQEKGDVICTKLKVTRKKV----RRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQ
.|||| || | ...  ..|||.   ..||.| | . |.....| |  .|.|..||       ....|   |. .|.|  .|| | ..|.|.....  ...
livmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykl

CgNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFD
  ..|..| ||.||||||.| |..|.|..||.|. .|.|...| .| . .  |.|  || |.|. . .| .
n.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 609-875 1.5e-67 222.7 In-house 18-278 (288) alignment
Range on Protein: 609-875
Range on HMM: 18-278/288.0
FQMTGYALEFQRLNSVTSReipaEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDY
 . ||.  |.. | .. .     .....|....| .|||. .|....  || |.. .  ...||||| ... .......|||| || .||.|||..| ..
rnrtgfseeynsLaalekt....ksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyen

DIGTIVMLNNLHELD-QEYPQYWPDHGA-TKYGHIGVSVLSKQEKGDVICTKLKVTRKKVRRktqEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQ
.. |||||..| | . ..  .|||| .  ..||.. | .....|..|..  || . .|| ..   |. .... .|||. .|| .  .|.||.  ....|.
ktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkktel...eitqyqylaWpdhgvPeskapllellrqvkvanqa

CgNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKY
    |..|.||.||||.||| |.  .......|..|||. .....| . .  |.  .|| |.|... . 
d.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsl

0042113 (Phosphotyrosine protein) phosphatases II 635-876 3.2e-67 221.8 In-house 2-243 (245) alignment
Range on Protein: 635-876
Range on HMM: 2-243/245.0
SVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQE-YPQYWPDH
||.. | | .|||.|||......|| | ..  |. |||||| . . .|  . |||||.|| |||||||||. ...| |||||....||... ..||||..
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

GATKYGHIGVSVLSKQEKGDVICTKLKVTRkKVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQCGNAPVLVQCSNGVGRSGTFCAISSVL
. ..||.. | .|| . ..|.....|.||. .   ...||.|.|...||| ..|.|  ..||.|..... .....| |||| || ||||.|||.|.  .|
esltygdftvtllseehlddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylml

ERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYF
|.|..|. .......|..|   ||||..| || |.|.......
eqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell

subfamily_PTPN13_pd Subfamily PTPN13 329-584 3.4e-67 221.6 In-house 15-270 (273) alignment
Range on Protein: 329-584
Range on HMM: 15-270/273.0
NEYKKFNNGQ-QFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGdedsdYINASFIHGYDGTP-RSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLT
.|.|.... . .   | ..| .||.|||| |.. ||..|| |.   |     |||||.|.   |    ..||.||||| . . ||.|||||... |.|.|
eefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvt

NLVELGKTKCHKYWPDK----IETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPrDAGPVIVH
. .| || |||.|||..    .  .. ..|.| . .   .. .|.. ... . . || | ...|. ||| |||. |. .| | ..|| |.  ||||..||
lekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvh

CSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALT
||||. |.||.|.||..|.  .. . .|... .  ||. |  .||||.|| |.. |.||.|.
csaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk

subfamily_PTPRN_pd Subfamily PTPRN 326-582 4.5e-67 220.8 In-house 30-291 (297) alignment
Range on Protein: 326-582
Range on HMM: 30-291/297.0
RLENEYKKFNNGQQFP--WEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIV
|||.|.. . . .. |   |.|... | .|||......|||||| |.. . .|.|||||||.|   |    ..||.||||.     ||.||||| .  ||
rlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvviv

MLTNLVELGKTKCHKYWPDK-IETYGGVTVTLHQSEIFA-DYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIV
.||.| | | ..|..||||.  |.|.   | |    |.. || .|.| |   . | .| | ||||  ||..|||  | ..| |||||       . |..|
nltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivv

HCSAGVERTGTYIVIDAMLEQAKK-SRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
|||.|. |||.||.|| .|.. .|  . .||   |  || .||..|.||.|. |. .|| | 
hcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaee

0040439 (Phosphotyrosine protein) phosphatases II 634-876 7e-67 220.9 In-house 3-246 (249) alignment
Range on Protein: 634-876
Range on HMM: 3-246/249.0
KSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHEL-DQEYPQYWPD
.||.. | |..|||..||......|| |.     . |||||| ...  .  ..|||||.|| |||||||||. ...|..||||..| ||  . . ||||.
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

HGATKYGHIGVSVLSKQEKGDVICTKLKVTRKkVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQC-GNAPVLVQCSNGVGRSGTFCAISS
 | ..||.. | .|| ..|.|.....|..|..    .. .| |.....|||  .|.   ..||....... ....  . |||| ||.||||.|||.|.  
ggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

VLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYF
.||.|..|. .|.....| .|   ||||..| || |.|.......
mleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell

subfamily_PTPRK_pd Subfamily PTPRK 636-872 2.5e-66 218.6 In-house 37-273 (314) alignment
Range on Protein: 636-872
Range on HMM: 37-273/314.0
VGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELD-QEYPQYWPDHG
.  . .| .|||. ||.| . .||.|.  . | .|||||| .. ...  .|||.||.|| |||.||||.| |..  .||||..| |    .  .|||...
aakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedt

ATkYGHIGVSVLSKQEKGDVICTKLKVTR-KKVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQcGNAPVLVQCSNGVGRSGTFCAISSVL
 . ||.| | ... . . ...   ..|.. ..   ...|| ......|||  .|  | ..|.|. . ..||.. .. ...| ||.| ||.|||.||..||
ev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivl

ERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQII
. ...|.|.|||...| .| . .  ||   || |.|..|
dmieregvvdvfnavktlrsrkvnmveteeqykfiydvi

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 602-884 4.1e-66 217.9 In-house 10-286 (287) alignment
Range on Protein: 602-884
Range on HMM: 10-286/287.0
LASVNRKFQMTGYALEFQRLNSVTSREipaEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHnehaDEESDYINAVFLHAHRGRNAFIATQHPLLETVEDF
..  ...   .|.   |. |..|| ||   .|  ..  .|| .|||...|.  .  ||.|.    .|. |||||||. ... ..|||... |. .|. .|
fvakghakgnegfknqftvleqvtqre...devthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnf

WRMVTDYDIGTIVMLNNLHELDQEY-PQYWPDHGATKYGHIGVSVLSKQEKGDVICTKLKVTRKKVRRKTQEVCHLHHVSWPDKC-IPELACSVLdLLDE
|... |  . .|||| ...| |.|   ||||.. .. .|.  ...|... . ..|  ||.|..|.   ..|.|   .  .|...  ..| . ..| ...|
WkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtill.viee

AQTSQQQCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFDSFSDYAN
   .|.. ||....| ||..||||..|||.   ... ||| |||||||.|. |.  ||.|   .|| | ..|...| |||. |..
myktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysd

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 607-882 7.5e-65 213.6 In-house 15-289 (290) alignment
Range on Protein: 607-882
Range on HMM: 15-289/290.0
RKFQMTGYALEFQRLNSVTSReipaEEKSVGEEPQNLHKNRFSDIIALNSCRVMLH--NEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRM
.. ...|.  .|..|.|  |     ..  ||  ..| ..|||..|.  .  |..|.  ..| | . .||||.... .. ....|||| |. .|. |||..
hakgnegfrnqfkmldsgese....htvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkl

VTDYDIGTIVMLNNLHELDQE-YPQYWPDHGATKYGHIGVSVLSKQEKGDVICTKLKVTRKKVRRKTQEVCHLHHVSWPDKC-IPELAcSVLDLLDEAQT
. . ..  |||| |  | ...   |||||.....||.. . .|. ..  . | .||.|. |.   ..|.| ...  .|...  ... . ..| .. | . 
iwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpq.tillvieemyk

SQQQCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFDSFSDY
 | . || ...| ||..||||..|||.   ... |||.|||||||.|. |.  || |..  || . .||. .|.|||. |
tqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 314-595 1e-64 213.7 In-house 9-291 (439) alignment
Range on Protein: 314-595
Range on HMM: 9-291/439.0
EYVAKMQANGGIRLENEYKKFNNGQQ-FPWEA--ARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPAFEGF
|.| |.. |    ......| |  .  .  .|  | .  .. |||| ...|.||.||.|. . |   | |||| .|.||  ... .||.|||   . . |
ehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyy.ddklyiatqgpkkettddf

WRMVWEQNSQSIVMLTNLVELGKtkchkYWPDKIETY-GGVTVTLHQSEIFADYEIRTFILSKAKR--SGSRMVRQFHFTVWPDKGVPQYATAVLAFRRK
||.|.|...  |||||||||  |     ||| . |.. | ..|   .   . .| || | . . .      | | |||.. |||| ||  |. || | | 
wrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflra

VRALNP-RDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSETY
. . |  .. |||.||||||| |||| | .|  ||| |    |||.  .  |||.| .|||.  || ||. |||| .  |.. .. . .
insandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidef

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 344-581 1.7e-64 212.4 In-house 14-262 (270) alignment
Range on Protein: 344-581
Range on HMM: 14-262/270.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK
      .|. ||||.|.   ..||.||... |. . |||| ...|.|| ....||..|||| . . ||||.||.....|||.|.|.| |..|| .||| .
lpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpae

IET-----YGGVTVtLHQSEIFADYEIRTFILSKAKRSGSRMVrQFHFTVWPDKGVPQYAT------AVLAFRRKVRALNPRD--AGPVIVHCSAGVERT
 ..     .| ..| | .||  ..  |.| .  . | .  |.|  |... |||.|||. .        .|.  |.||. . .   |.|..|||||||.||
pkekvkledgkikv.lalseekeegyiltrlrleekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRt

GTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
|| |..| ...  .... ||. . . .|||||. .||. ||| |.. ||.|
GtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve

subfamily_CG7180_pd Subfamily CG7180 344-587 3.7e-64 211.2 In-house 36-294 (296) alignment
Range on Protein: 344-587
Range on HMM: 36-294/296.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKtKCHKYWPDK
.. .  |..|||. ..| ||. |||||...|.|.||||||... ..   .. .|  ..|   . . |||.|........|.||.  .  | ....||| |
gglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsfl.kkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnk

-IETYGGVTVTLHQSEIFADYEIRTFILSKA----------KRSGSRMVRQFHFTVWPD-KGVPQYATAVLAFRRKVRALNPRD-----AGPVIVHCSAG
  | || . | . ... .|. .|||| | |                |.|..|..|.|.  . ||  ..|.. .||.|| .  .       |||.|..| |
skeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdG

VERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGN
. |.| |. ||| ||...|   ||. ...  ||..||..|...|.| .|   .|||. |. 
asRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk

0045098 (Phosphotyrosine protein) phosphatases II 632-876 4.1e-63 208.7 In-house 23-272 (278) alignment
Range on Protein: 632-876
Range on HMM: 23-272/278.0
EEKSVGEEPQNLHKNRFSDIIALNSCRVMlhnehadeesDYINAVFLHAHrgRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHEL-DQEYPQYW
 | ...  . ||.|||..||......||           ||||| ... .  ...|||||.|| .||.|||||. ...| .||||..|.||  . ..|||
seitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqyw

PDHGATKYGHIGVSVLSKQEKGDVICTKLKVTRK---KVRRKTQEVCHLHHVSWPDKCIPELA--CSVLDLLDEAQTSQQ------------QCGNAPVL
|..|   ||.. | .|| .. .|.. ..|.||     .   .. .|.||| ..||| ..|.|    |.|.||.. .  ..            . .. |||
peggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvl

VQCSNGVGRSGTFCAISSVLERLktEQVIDVFQVIKRIRVNLPG-AVESPTQYLFCYQIIQKYF
| || ||||.||..|.  .||.|  |...|.....| .|   || ||... || |.|. .....
VHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 637-875 1.1e-62 206.8 In-house 44-278 (315) alignment
Range on Protein: 637-875
Range on HMM: 44-278/315.0
GEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQEYPQ-YWPDHgA
  . .| .|||. .||| .  || |     |..|||.|| |.  .  .. .||.| |. ..|.||||.| ..|||.||||.|| | ...  . ||||.  
akkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.k

TKYGHIGVSVLSKQEKGDVICTKLKVTRKKvrrKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQCGnAPVLVQCSNGVGRSGTFCAISSVLER
  ||.| |.  |.. . .. .  | |. ..   . .||  ||. ||||  .|. . ....|   ..  ...   ....| ||.||||.|||.....||..
viyGkitvtrkseevnteytvrtlsvvfgd...nirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavldq

LKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKY
...|..|||...|...| |  ..|..  || | |... . 
aeaenaidvynfitgvrqnrikmvqvaeqyqfiydallet

subfamily_PTPRG_pd Subfamily PTPRG 612-876 1.7e-62 206.5 In-house 19-287 (563) alignment
Range on Protein: 612-876
Range on HMM: 19-287/563.0
TGYALEFQRL-NSVTSREIPAEEksvGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEES-DYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYD
.|.. ||. | . ..|....||     ..|.| .||| ..|.| .. || |..    ... ||||| ... ..  .||||||.|| .|..|||||. .  
igfseefealqsetiskdldaeh...sqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqn

IGTIVMLNNLHEL-DQEYPQYWPDHGATKYGHIGVSVLSKQEKGDVICTKLKVTRKKVRRKT-----QEVCHLHHVSWPDKCIPELACSVLDLLDEAQTS
  .|||. || |   .. ..|||  .. .||.. |   ... .      .|..   |...|      ..| . |  .|||.. || .  ||     ....
vaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaa

QQQcGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYF
...    |..| ||.||||.||.......|.....|....||...|.|| . .  |..  ||.| ......  
nka.eaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleai

subfamily_PTPRB_pd Subfamily PTPRB 591-877 4.5e-62 204.7 In-house 8-286 (293) alignment
Range on Protein: 591-877
Range on HMM: 8-286/293.0
QSETYNQAMQKLASVnrkfQMTGYALEFQRLNSVTSREipaeEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIAT
. |.... ..|...     . .... |...|..| . .    .... |...|  |||...|.. .  || |.. . ...|||||| ... .. .. ||||
klekfeehvkkmkad....sdlrfseeyeelkavgkdq....avkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiat

QHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ-EYPQYWPDH-GATKYGHIGVSVLSKQEKGDVICTKLKVTRkkvRRKTQEVCHLHHVSWPDKCIPE
| || |||.|||||| .    .|||| .| |  .    .|||..  .. ||.| |......|. | .. .||...   ......| ..|..||||  .||
qGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPe

LACSVLDLLDEAQTSQ-QQCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFD
 . ..||.. . .... ... ..|..| || ||||.||| |.  .|.....|...|.| .. ..| .    | . .||.| .| ..... 
ktktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr

subfamily_PTPN12_pd Subfamily PTPN12 612-877 6e-62 204.1 In-house 8-278 (290) alignment
Range on Protein: 612-877
Range on HMM: 8-278/290.0
TGYALEFQRLNSVTSREIPAE--EKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYD
  .| |||.| .....    .  ....||...| .|||. ||.  .  ||.|.... .|.|||||| |..   |. ..||.| || .|..|||||. ...
eefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiwekn

IGTIVMLNNLHELDQEY-PQYWPDHGAT--KYGHIGVSVLSKQEKG-DVICTKLKVTRKkvrRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQ
.  .||. .. ||..    .|||..| .  ..|.. |.. ...    | .   |||...   .....|  .|. .|||. .|. | |.|.|...... |.
veivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe

qCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQV---IDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFD
   .||..| || |||| || .||  | | ||.|..   .|||... ..| . . .| .  || . |. . ... 
.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 634-878 3.2e-61 202.0 In-house 43-286 (297) alignment
Range on Protein: 634-878
Range on HMM: 43-286/297.0
KSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGrnAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQEYPQYWPDH
. | |.  |..|.|...|.  .| ||.|.    | .|||.|| |... .    .|.|| |  .||.|||.|| |... ||||||...| |..  .||.|.
qtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdk

GATKYGHIGVSVLSKQEKGDVICTKLKVTRKKVrRKTQEVCHLHHVSWPDKCIPE--LACSVLDLLDEAQTSQQQCGNAPVLVQCSNGVGRSGTFCAISS
| |..|.. | .|| .|.   |  .|.||. |  .... |   ..|.|||| ...   | |.|.|..| . . .|  ..|.|| |..|||| | ...| |
gvttfGdvsvvllsvsereGfikrelevtkgka.karrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltids

VLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFDS
|. . | |. .|.|...|..| . |  |    || | |... ... |
vvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlealls

0037934 (Phosphotyrosine protein) phosphatases II 637-876 7.8e-61 201.0 In-house 5-242 (243) alignment
Range on Protein: 637-876
Range on HMM: 5-242/243.0
GEEPQNLHKNRFSDIIALNSCRVMLhnehadEESDYINAVFLHAHrGRnaFIATQHPLLETVED----FWRMVTDYDIGTIVMLNNLHEL-DQEYPQYWP
.  |.||.|||.|||....  || |      | |||||| .     .|  .||||.|| |||||    ||||. ...|..||||..| ||  . ..||||
allpenlsknrysdilpydhsrvkl......egsdyinanliyvt.pr..liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

dhGATKYGHIGVSVLSKQEKGDVICTKLKVTRKKVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQ-------CGNAPVLVQCSNGVGRSG
  | . ||.. | .|| ....|.. ..|......    |..|.|.|...||| ..|.   ..||.|||... ...        .. |||| || ||||.|
..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtG

TFCAISSVLERLkteQvIDVFQVIKRIRVNLPG-AVESPTQYLFCYQIIQKYF
|..|.  .|..|   . .|.....|..|   || ||..| || |.|.......
tliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallell

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 611-876 8.3e-61 200.9 In-house 22-288 (325) alignment
Range on Protein: 611-876
Range on HMM: 22-288/325.0
MTGYALEFQRLNSVTSReipaeEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDI
  |.| ||. | |. .       | |   |.|  |||| ...||.  ||.|   . | .|||||| .|. ..... |.|.| || .|..|.||.| |.  
qdgfahefgllpsddgi.....akkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrc

GTIVMLNNLHELDQEYPQYWPDH--GATKYGHIGVSVLSKQEKGDVICTKLKVTRKKvRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQ---Q
  .|.|| | . ...  .|||..   . ..| . |.. . .|  | .  .|.| . | . .|. |  ... ||.|   ..  .... .|.  .. .   .
svvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvk.kGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservt

--QCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYF
    . .|.|| ||.||||.|.| .. |.|... .|  .|.|...|..| . |  ||.  || ..|. . ...
antkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay

subfamily_PTPN23_pd Subfamily PTPN23 328-582 3.6e-59 195.0 In-house 18-279 (288) alignment
Range on Protein: 328-582
Range on HMM: 18-279/288.0
ENEYKKFNNGQQ-----FPWEAARkpANKNKNRYANIVAYDHSRVVLErvngDEDSDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSI
....|.... |.     .   .|.   . .|||. .|. |||.||.|.    ..  |||||||...   .  .|||.|.||...   ||.||.|| |. |
dkkfkeleqkqdkearkrsiaiak..lyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssvi

VMLTNLVELGKTKCHKYWPDK---IETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRA----LNPRD
|||..  ||||.|...||| .    ...| ..|||.. .    .  |...|.  . .  ..|.  ..| ||. |||.    .|.|  .|..     . . 
VmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrks

AGPVIVHCSAGVERTGTYIVIDA-MLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
  |..|||||||.|||.. .. | . |  |.   .|| . .  ||..| .|||.|||. |  .|||||
ktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 320-589 9.8e-59 193.5 In-house 13-299 (301) alignment
Range on Protein: 320-589
Range on HMM: 13-299/301.0
QANGgirLENEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNG--DEDSDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMVWEQ
..|.   .|..||. ..|.. . .   . .||. ||. ||. ||. |..|.  .       .|||||.|.||  . . |||.|||.      |||..|..
hsnk...feeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysek.kkfiaaqgpmkktlvdfWrliwqe

NSQSIVMLTNLVELGKTKCHKYWPD---KIETYGGVTVTLHQSEIFADYEIRTFILSKA---------------KRSGSRMVRQFHFTVWPDKGV-PQYA
  .||||.||| |  |.||..|||.   . |..| .||||... .. |. || . .                  ..  |. | |.. | ||. || ....
kpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvrepr

TAVLAFRRKVRALNPRDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTE
| . .    . . .  . |||.||||..| |.|.|. ..  |||.|    ||. .   |.|. .| .|.| |||..|. .. . |.. .|.
tvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnsty

subfamily_PTPN9_pd Subfamily PTPN9 631-875 6.8e-58 191.0 In-house 31-289 (297) alignment
Range on Protein: 631-875
Range on HMM: 31-289/297.0
AEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ-EYPQY
. .  . . . ||.|||..|.. ... ||.| ... ||.|||||| |.  .. ..|||||| || .||.|||||| . .. .|||   . |  .    ||
eGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqy

WP--DHGATKYGHIGVSVLSKQEKGDVICTKLKVTRKKVrRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQ------------QQCGNAPVLVQ
||  .. ....|.. ||... .|. |   ..|.... |  .....| |   .||||  .|. | |.||.|....  |             .. . |..| 
Wpleeessaefgdlsvsnveveeeedykvrvleiknvkt.eesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvh

CSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKY
|| |.||.|||...   |.||......||....|..|     ..  | || |||. .  |
csaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 629-876 1.3e-57 190.1 In-house 31-277 (315) alignment
Range on Protein: 629-876
Range on HMM: 31-277/315.0
IPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ-EYP
 .. .. |. |..| .|||. .|. |.| ||.|     . .|||||| ....    .|.||.| ||  .|.|||||| .... ||||.....| |. .  
PdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcr

QYWPD--HGATKYGHIGVSVLSKQEKGDVICTKLkVTRKKvrRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSqQQCGNAPVLVQCSNGVGRSGT
|||||    ....| | |..|| .  .| .  || ||||    ... |   .   |||| ... . |.| |. | ... ..  . ..|| || ||||.| 
qywPdrkadsvefGsikvellsleadtdgvarkl.vtrks..eesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGv

FCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYF
...| .|....| ....|||...| .| . |  | .  .| | |.......
visidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledl

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 605-877 2.4e-57 189.2 In-house 8-277 (281) alignment
Range on Protein: 605-877
Range on HMM: 8-277/281.0
VNRKFQMTGYALEFQRLNSVTSREIpAeekSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRM
 ... . .|.. |.. |...  ..  |   .  ....| .|||.|.|.| .  || ..........||||| |. . .| ...|||| |. .....||.|
qlsqndnaGfieeyeklaaigvdnt.a...taskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqm

VTDYDIGTIVMLNNLHELDQ-EYPQYWPDHG-ATKYGHIGVSVLSKQEKGDVICTKLKVTRKKvrRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQT
| .... .|||. .  | ..    .||||.  ..|||.. |. ....||   |. |.|..|..   .|.|| .|....|||. .|. .  .|.  .| . 
vweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleres..getreveqlaytaWPdhGvPattkellefrkevlk

SQQQCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTE-QVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFD
 ...  .||... || ||||.||. |.  .......| . .|| .|.. .| .    | . .|| | |... ...|
ltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 611-881 4.5e-57 188.7 In-house 33-297 (319) alignment
Range on Protein: 611-881
Range on HMM: 33-297/319.0
MTGYALEFQRLnsvTSREIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDI
.| .  ||.|.   . . ..  ...  . .||  |||. .|.| .  .| |..    | |||||| |.  .. .. .||.| || .|..|||||. .|..
ltklevefrra...cklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweync

GTIVMLNnlhelDQEYPQYWPDHGATKYGHIGVSVLSKQEKGDVICTKLKVTRKKVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDE-AQTSQQQCGN
 |||.|       .   |||| ..  |...  |.| | .|  . .  .......   .  ...   |   |||.  |. .  .. |..      ... ..
stivllt.....kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhr

APVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQK-YFDSFSD
|...| || ||||.|.. ..  .|.|.| |. .||..... .| . .  |.. .|| |.|  . . .. ..||
anivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsd

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 634-875 1.8e-56 186.3 In-house 35-275 (515) alignment
Range on Protein: 634-875
Range on HMM: 35-275/515.0
KSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQE-YPQYWPD
..| .|  | .|||. .|. ..| || |   . . .|||.|| ....    .|.||.| |.  .|.||||.| .... ||.|...|.| |.    .||||
qtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPd

--HGATKYGHIGVSVLSKQEKGDVICTKLKVTRKKVrrkTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQCGnAPVLVQCSNGVGRSGTFCAIS
    . |.|.| |...| .  .. |  ||.|.. .    .. |   |   |||| .|. . |.| |. | .....|    |... || |||| | ...| 
kpgdsvkfGsikvelvsleactggikrkltvlkgdd...srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtGvvisid

SVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKY
||. . || ...|||.... || . |  |    || | |.... .
svvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavled

subfamily_PTPN6_pd Subfamily PTPN6 588-878 1.9e-56 186.3 In-house 2-299 (306) alignment
Range on Protein: 588-878
Range on HMM: 2-299/306.0
TEIQSETYNQAMQKLASVNRKFQMTGYALEFQRLNSVTSREIpaEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHnEHADEESDYINAVFLH--AHRGRN
|.. ... .| ...|   . ... .|.  ||..|.   ...    ... |. |.| .|||.  |.  .  ||.|. |.   .|||||| ...  ..  ..
tsllakeieqrvselekeeeslekagfeeefeelqqeeakkl..lsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdk

AFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ-EYPQYWPDHGAT-KYGHIGVSVLSKQEKGDVICTKLKVTRKKVRRKTQEVCHLHHVSWPD
..||||  | .||.|||||| . .   |||. .  |  .    .||||. .. .||.| |. .|.... | |  .|.|..||  ....|| ..|. ||||
syiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPd

KCIPELACSVLDLLDEAQTSQQQCG---NAPVLVQCSNGVGRSGTFCAISSVLERLKTE---QVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFD
. .|.    |||.|.. .. |...    . |..| ||.|.|| |||  |  .|. ....     ||. ...| .|    | |   .|| | |..|.|| .
hgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyie

S
.
t

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 626-881 4e-56 185.6 In-house 9-261 (284) alignment
Range on Protein: 626-881
Range on HMM: 9-261/284.0
SREIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNnlhelDQE
 . ... ...  . .||  |||. .|.| .  .| |..    | |||||| |.  .. .. .|||| || .|..|||||. .|.. |||.|      .. 
klgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.....kdk

YPQYWPDHGATKYGHIGVSVLSKQEKGDVICTKLKVTRKKVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDE-AQTSQQQCGNAPVLVQCSNGVGRSG
  |||| ..  |...  |.| | .|  . .  .......   .. ...   |   |||.  |. .  .. |..     .... ..|...| || ||||.|
csqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtg

TFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQK-YFDSFSD
.. ..  .|.|.| |. .||..... .| . .  |.. .|| |.|  . . .. ..||
vyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsd

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 334-580 5.3e-56 184.5 In-house 22-274 (287) alignment
Range on Protein: 334-580
Range on HMM: 22-274/287.0
FNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLErVNGDEDSDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGK
  ..  . . || . |. .|||||... .|..||.|   .|.  |||||| .. .|     .|||.|||.. .   |||.|.|..| |....|  || ..
dsesstatfkaaeelaavkknryadvlPiddtrvlls.aegelGsdyinanyvasytdd.eafiaaqgPiaatvrdfwravletrsasvitmtreveear

TKCHKYWPDKIE--TYGGVTVTL-HQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKV-----RALNPRDAGPVIVHCSA
 ||.||||..      || .|.|  ..    .| .|.. | ...   .|.|.|...  ||||...  | ... |  .|      | .  ..||..||...
lkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddv

GVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVL
|. |.|... . ..... ..   ||. . .| ||. |  .||.  |. ..  |. 
GiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv

subfamily_PTPRD_pd Subfamily PTPRD 725-883 2.3e-55 183.3 In-house 132-288 (564) alignment
Range on Protein: 725-883
Range on HMM: 132-288/564.0
EYPQYWPDHGATKYGHIGVSVLSKQEKGDVICTKLKVtRKKVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQqQCGNAPVLVQCSNGVGRSG
.. .|||..| ..||.. |.. ...|. |......|. .|| .....|| . |..||||...|| |.|.|||... .... .... |..|.||.||||.|
kchkYWPekgtetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTG

TFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFDSFSDYA
||..|...|||.|.|...|..|..|..| . .  |....|| |....|... .....  
tfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntev

subfamily_PTPN14_pd Subfamily PTPN14 341-583 3.9e-55 182.0 In-house 40-296 (300) alignment
Range on Protein: 341-583
Range on HMM: 40-296/300.0
PWEAARKPANKNKNRYANIVAYDHSRVVLERVNgDEDSDYINASFIHGY-DGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKY
  ..|. | |..|||. ... |...|| |   . .....||||| |.    |. ||.|..||||. . . ||.|||||. | |||||.  | ||.|..||
llstaklpenaeknrfkdvlPyednrvelsptk.enstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfky

WPDK-----IETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR---------DAGPVIVHCSA
.|..       ..|   || . ||    .  ... |     .  | |  . .| |||.|||.  .  | . ..|...  .            ||.|||||
fPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsa

GVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
|| |||  |. | ...  .. ...||.. |  ||. | ..|||  || |....... |
GvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl

subfamily_CG7180_pd Subfamily CG7180 610-876 8.9e-55 180.4 In-house 11-290 (296) alignment
Range on Protein: 610-876
Range on HMM: 11-290/296.0
QMTGYALEFQRLNSVTSReIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYD
..  . .|.. .  .|.| .  ..   | . .|. |||  ...  .  ||.|.. . .|.|||||||.  ..   ...| |. |  |||..|||.| | .
krrkfrveyklelkltpr.leigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydee

IGTIVMLNNLHELDQEYPQYWPDHGATKYGHIGVSVLSKQEKGDVICTKLKVTRK---------KVRRKTQEVCHLHHVSWPD-KCIPELACSVLDLLDE
| ..|.| .  .  . ||.||| .. ..||.| | ......  ..   ..|.|.|         .|  .|  |....   |.  . .|  . ....|.  
isavvvLtktfdfakmypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrr

AQTSQQQC----GNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYF
... ...      ..||.| .|.|..||| ..||   || .. |. .|||. .|..| . |. ||. ..| ..|.......
vrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 640-877 3.2e-54 178.8 In-house 26-269 (274) alignment
Range on Protein: 640-877
Range on HMM: 26-269/274.0
PQNLHKNRFSDIIALNSCRVMLHNEHADEE-SDYINAVFLHAHRG-RNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ-EYPQYWPDHGAT
. . .|||. .|.  .  ||.|..|....| |.|||| ...  ..  .|..||| || .||.|||||.   ..  |||| .|.| ..    .|.||.  .
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

----KYGHIGVSVLSKQEKGDVICTKLKVTRKKVrrkTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQCG--NAPVLVQCSNGVGRSGTFCAIS
    .||.. . | .. |. |   .|| .   .    ...| |  . .|||.  |. | ..|||..| ..|...     |||.| || |.|| | | |||
eiserygdveikvekiverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiais

SVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFD
  . .|. |.|.||....  .|..  | |..  || . .... .|  
iavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk

0051429 (Phosphotyrosine protein) phosphatases II 378-602 4.9e-53 175.8 In-house 4-243 (272) alignment
Range on Protein: 378-602
Range on HMM: 4-243/272.0
SDYINASFIHGYdGT---PRSFIASQGPLPPAFEGFWRMvWEQNSQSIVMLTNLVELGKTKCHKYWP-------------DKIETYGGVTVTLHQSEIFA
|.||||... || |    |. ...|.||||   ..|||. .|..  .||.|....|.|. ||..|||             .   .|| ..|||.. |.. 
sgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

DYEIRTFILSKA-KRSGSRMVRQFHFTVWPDKGVPQYAtaVLAFRRKVRAlnprdAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVD--------IR
|| .|...|..  . . .|.|...|.| ||| |||| |  .|.. . ...      |||.||||||. ||||..... .|..  ..  ||        ..
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyle

NYLIALRKDRPHMVQTKEQYSFIHSAVLEAlTCGNTEIQSETYNQAMQKL
...  ||. ||..||| ||| |.. |.||.  .. .... |....|.. .
eaveelraqrpgavqteeqylflyeallel.lrsllsvraeyllaaldai

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 632-884 1e-52 173.8 In-house 30-301 (301) alignment
Range on Protein: 632-884
Range on HMM: 30-301/301.0
EEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHA--DEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHEL-DQEYPQ
.. .|| . .| . ||| .|  ..  |..|.....    . .|||| .... . ...|||.| |. .|. ||||.. ..   .|||. ||.|   ..  |
ksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceq

YWPDHGATK--YGHIGVSVLSKQEKGDVICTKLKVTRK--------------KVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQCGNAPV
|||.  |..  .|.. | . ..|   | .  .|.|. .              | ......|  |. ..||.  .      ||  .|.    ||. | .||
ywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpv

LVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFDSFSDYAN
.| ||..|.|||..|..|  ||  | | |.|||||.|..| . ||||    || . |..|..|.   | |||
vVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstyan

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 342-591 1.3e-52 173.5 In-house 25-274 (283) alignment
Range on Protein: 342-591
Range on HMM: 25-274/283.0
WEAARKPANKNKNRYANIVAYDHSRVVLERVNGdedsDYINASFIH--GYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKY
 . |    ||.|||. .||..|  || |.  .     |||||.||     .   . .|..|.||  .   ||.||....  .|||||.| |  . || .|
adiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqy

WPDK-IETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRM-VRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVERTGTYIVID
|| .  | ||  ||||..      . |. ..| .   . | . .  . .  | . |      ... | . .   .    ||..||||.|. ||...| . 
WPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaas

AMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQ
| ...|. .  ||. . .  .|..|. .|||..|| ..| .|||   ||.|.| 
asvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqia

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 612-872 7.2e-52 171.0 In-house 6-262 (283) alignment
Range on Protein: 612-872
Range on HMM: 6-262/283.0
TGYALEFQRLNSVTsreIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHAdeesDYINAVFLH---AHRGRNAFIATQHPLLETVEDFWRMVTDY
... | ...|. ..   .|  .  .    .| .|||. .|.. .  || |..|      |||||||.     ..  . .|..| || .|| |||.|| | 
nnnklfrevlkrls...vpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfde

DIGTIVMLNNLHE-LDQEYPQYWPDHGATKYGHIGVSVLSKQEKGDVICTKLKVTRKKVRRKTQEVCHLHHVSWpDKCIPELACSVLDLLDEAQTSQQQC
.| .|||| .| | |...  |||| .|. .||   |..     .   |  .| .  .   ..|  ..|   . |  .. ..     |  ..  .. |.. 
kitaivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW.leygeqaiinslvkfnkvislqtes

GNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQII
 ..|..| ||.|.||...|.|.|. .. ..|| |.|||.|.| .|.....|| .  || . ....
kkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv

subfamily_PTPN23_pd Subfamily PTPN23 611-875 4.3e-51 168.4 In-house 14-279 (288) alignment
Range on Protein: 611-875
Range on HMM: 14-279/288.0
MTGYALEFQRLNSVTSREipAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHnehaDEESDYINAVFLHAH-RGRNAFIATQHPLLETVEDFWRMVTDYD
 |.   .|. |..   .|  |...|.     . .|||. ||.  .. ||.|.    ... ||||| |..    |   ||||| || .|. |||.|| .  
ktaldkkfkeleqkqdke..arkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqk

IGTIVMLNNLHELDQE-YPQYWPDH--GATKYGHIGVSVLSKQEKGDVICTKLKVTRKKVRrKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQT---S
  .|||| . .||...   .||| .   ..|.|.. |.. |..| . ..  .||.. .... ....|.||.  |||.  .|.   ..|..|||...   .
ssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldad.avksvshlqltsWpelGvPasPetllqfldevesayea

QQQCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTE-QVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKY
.|.  ..|..|.|| ||||.|.|. . .... |...  ..|. ||..|.| .    |.  .|. |.|... ..
vqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea

0041856 (Phosphotyrosine protein) phosphatases II 350-589 3.9e-50 165.3 In-house 1-177 (182) alignment
Range on Protein: 350-589
Range on HMM: 1-177/182.0
NKNKNRYANIVAYDHSRvvlervngdeDSDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTnlvelgktkCHKYWPDKIetygg
|..|||| .|. |||||          |.|||||... |.  . | ||| ||||.  .. |.||..|.. ..||.||         .. |||..      
nldknrysdilpydhsr..........dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywpell.....

vtvtlhqseifadyeirtfilskakrsgSRMVRQFHFTVWPDKGVPQyATAVLAFRRKVRAlnprDAGPVIVHCSAGVERTGTYIVIDAMLEQakksrTV
                             |.. |.... ||| |||     .|.| ..|..    . |||.||||||| ||||..... |...      |
............................erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gv

DIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTE
.... .  .|. ||.||.| .|| |.. |.|| | ...|.
sleeavklvrsrRpgmvitpnqyfflqlallellllkktr

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 632-877 1.1e-48 160.5 In-house 10-265 (270) alignment
Range on Protein: 632-877
Range on HMM: 10-265/270.0
EEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLH-AHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQEY-PQY
.|... |  .. . ||. ||.     ||.|.... |... |||| ... ..  ....||.. ||  |...||||. .    .|||. .|.|  ..   .|
sesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerY

WPDHGA----TKYGHIGVSVLSKQEKGDVICTKLKVTRKKvrrKTQEVCHLHHVSWPDKCIPELAC------SVLDLLDEAQTSQQQCGNA-PVLVQCSN
|| .      ...|.| | .||.. .   | |.|....|    ......| ....|||. .|. .       ..| .| . . |...  .| |.|| ||.
Wpaepkekvkledgkikvlalseekeegyiltrlrleekg...eerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsa

GVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFD
||||.||. |.  ... |.... .|| ..|...| . .  |. | || | |. ...| .
GvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae

subfamily_PTPN3_pd Subfamily PTPN3 628-877 1.1e-46 154.0 In-house 27-277 (280) alignment
Range on Protein: 628-877
Range on HMM: 27-277/280.0
EIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHAdeesDYINAVFLHAHR----GRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELD
  |  . |.   |.||.|||. ||.. .. ||.|.....    ||||| ..          | .|||| || .|..|||.|| . .. .|||| .| |  
kkpglaisaarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverG

-QEYPQYWPDHG-ATKYGHIGVSVLSKQEKGDVICTKLKVTRKKVRrKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQqQCGNAPVLVQCSNGVG
 .   ||||...  ..||.. | . ...|.  ..  .| ...|. . . ... .| ...|||...|. . ..|..... .. . .  . ||.| || |.|
rvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketk.eerkilqlqylaWpdhgvPddsadflefvervrklr.sgkeePvvvhCsaGig

RSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLF-CYQIIQKYFD
|.| . ..   |  . ... . . ......|      |....|| | |  |.. | .
rtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvyee

0036282 (Phosphotyrosine protein) phosphatases II 378-576 1e-45 150.9 In-house 2-163 (174) alignment
Range on Protein: 378-576
Range on HMM: 2-163/174.0
SDYINASFIHGYDGTPrSFIASQGPLPpafegFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDkietyggvtvtlhqseifadyeirtfilskAKRSG
|||||||.....  ||  .||.||||.     ||.|..|......|||....|||..||. |||.                               . . 
sdyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..............................lredl

SRMVRQFHFTVWPDKGVPQYATaVLAFRRKVRALNPR-DAGPVIVHCSAGVERTGTYIVIDAMLEQAKkSRTVDIRNYLIALRKDRPHMVQTKEQYSFIH
.|.. |.... ||| |||  .. .| | . |.    . . |||.||||||| |||| .... || . . ...||. ... .||. ||.|||| .|| |..
erlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly





subfamily_PTPN13_pd Subfamily PTPN13 612-873 1.2e-45 150.9 In-house 11-266 (273) alignment
Range on Protein: 612-873
Range on HMM: 11-266/273.0
TGYALEFQRLNSVTsreiPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHAdeesdYINAVFLHAHRGRNAF--IATQHPLLETVEDFWRMVTDYD
   | ||. |. .     | .. .||.. .| .|||. ...  .  || | .| .     |||| ..... | . .  ||.| || |||.|||.|| . .
qqPaeefkelrelk....pldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqk

IGTIVMLNNLHELDQ-EYPQYWPDHGATK---YGHIGVSVLSKQEKGDVICTKLKVTRKKVrRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQ
   |.|. .  | ..    .|||..   |   .. . |..|  |.. .    .|.|. ..  ....|| ||. |.|||  .|  | ..| .. | .. |.
aeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdses.gesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt

qcGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQ
   ..|..| || |.|||||. .|  ||. .. .. .|| ......|    | | .  ||.|.|..| 
..dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykail

0051429 (Phosphotyrosine protein) phosphatases II 670-879 1.4e-45 151.4 In-house 4-228 (272) alignment
Range on Protein: 670-879
Range on HMM: 4-228/272.0
SDYINAVFLHAHRG---RNAFIATQHPLLETVEDFWRMvTDYDIGTIVMLNNLHELDQEY-PQYWP------------DHGATKYGHIGVSVLSKQEKGD
|.|||| ..    .   .........||  |..||||.  ...| |||.| ...|....  ..|||            ..    ||.. | .||.. . |
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

VICTKLKVTRKKVRRKTQEVCHLHHVSWPDKCIP-ELACSVLDLLDEaqtsqqqcgNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVID--------V
.|...| .|..    .. || |||. .||| ..| |  ...|.|| .         . |||| || |..|.||..|.  .|...  |...|        .
yilrellltlllsagearevmhlhytdwpdhgvpqeallellellld.........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

FQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFDSF
.......|   ||||....||||.|........|.
eeaveelraqrpgavqteeqylflyeallellrsl

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 334-581 5.1e-44 145.0 In-house 40-281 (290) alignment
Range on Protein: 334-581
Range on HMM: 40-281/290.0
FNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLErvNGdEDSDYINASFIHGydgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGK
.  .|..  .   | .. .|||| ..|  | .||.|.  .|  | ||. | ...|   .   || .||.|  .   .|||| ...   |||| .|.| ||
ylpvqylerkifdkntefkknrykdvvcndktrvilk..dG.ydGdyvhanyvkG...lkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGk

TKCHKYWPDK---IETYGGVTVTLHQSEIFADY-EIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALnprdAGPVIVHCSAGVER
.||..|.|.|   . |.| .||.  ...   .    .|. . . .   . ... ..   |||| |.. . |.|   | .| .    .|||.||||||. |
akceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka....sGpvvvhcsaGiGr

TGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
|||.. |.. |.   . . .|. .   |||. |   ||   ||  .  ..|.
tGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 639-873 9.6e-44 144.5 In-house 45-276 (439) alignment
Range on Protein: 639-873
Range on HMM: 45-276/439.0
EPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQeypqYWPDHGATKY
.  .  |||. |. |..  ||.|..      | |||| ... .   . .|||| |  ||..||||.| .    ||||| || |  .    |||  . . |
qeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk....ywpsdaevcy

GHIGVSVLSKQEKGDVICTKLKVTRKKVR-RKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQCGNAPVLVQCSNGVGRSGTFCAISSVLERLK
| | | |  . |  . .   .||  .. . .| . | ..|...|||| .|  |  |||.|   ......    ||.|.|| ||||.||  |.   ||.||
gdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlk

TEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQ
.|. .|.  ..| .| .    |..  ||.| |. . 
lenkvdikgivkvlrkqrkqmvqalcqyvfiynavl

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 317-598 1.7e-43 143.8 In-house 8-288 (307) alignment
Range on Protein: 317-598
Range on HMM: 8-288/307.0
AKMQANGGIRLENEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLErVNGdEDSDYINASFIhGYDGTPRSFIASQGPLPPAFEGFWRMVWE
 .    |  .| .|.... . .     .    || .|||| .. . |..|.|.. ..|   |||| | .. |    |. ||..||||  .   || |. .
qrtldkgvqalvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvk.fdg.lasdyihanyl.giaikpkkficaqgplentqysfwamaiq

QNSQSIVMLTNLVELGKTKCHKYWPD---KIETYGGVTVTLHQ-----SEIFADYE-IRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFrrk
.. .|..|| ...||.| ||..|||    .  ..|  . |.        ..  | . |    |     ..|| .... .. |||.||||   . . .   
ekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainl...

VRALNpRDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKS-RTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALtcgnTEIQSETYNQA
. | .  |  ||.||||||| |.|| . |  . ..  .     |... .  ||..|.. .||. || ..|  .|| .     |   |||.. 
leavr.ydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf....lelyketyeel

subfamily_PTPRN_pd Subfamily PTPRN 630-872 1.4e-42 140.4 In-house 44-288 (297) alignment
Range on Protein: 630-872
Range on HMM: 44-288/297.0
PAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRN-AFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQEY-P
  . |.|.....|..||| ..... .  || |..| ..|.|||||| ..  |  |. |.|||| || .|| |||.|| .  .  ||.| .|.| . .   
epstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqck

QYWPDHGATKYGHIGVSVLSKQEKGDVICTKLKVTRKKVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQcGNAPVLVQCSNGVGRSGTFC
.||||.|.  |.   | ..|.    |    .    .    ..|. |  .|..|||.. .|  | |.|..    . | .    .|..| ||.|.||.|...
rywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG.rscpivvhcsdGaGrtGvyi

AISSVLERL-KTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQII
.|  ||.|| |  . ||.   .. .| . || |..  |. |... .
lidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltav

0049772 (Phosphotyrosine protein) phosphatases II 340-584 1.6e-42 141.7 In-house 36-281 (314) alignment
Range on Protein: 340-584
Range on HMM: 36-281/314.0
FPWEAARKPANKNKNRYANIVAYDhSRVVLERVNGDeDSDYINASFIHGYdgtpRSFIASQGPLPPAFEGF----------WRMV--WEQNSQSIVM---
. . .|....|..|||| .|. .| .||.| ..... .|||||||...|.    ..|||.||||.  .. |          ||||  ...|.  |||   
ltilvadlflnrdknryldilpad.nrvilpglpvs.gsdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrd

------------------LTNLVELGktkcHKYWPDKIETYGgvtvtlhqseifadyE-------IrtfilskakrsgSRMVRQFHFTVWPDKGVPqYAT
                  |..| ..|      ...  .|..                |                    .|.. ... . .|| ..|    
evladelsrLdaAlgKtpllildgng....neptaadlellk...............eelydpelf............erlgikylripvpDgsap.lle

AVLAFRRKVRALnpRDAGPVIVHCSAGVERTGTYIVIDAMLEQAKksrtVDIRNYLIALRKDRP-----HMVQTKEQYSFIHSAVLEALT
 ...| . ....  .. |||.|||.||. ||||..|.. .. . .    |...  |  .|. ||     ..... ||| ||. |.||.| 
dfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefilealleylk

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 617-875 4.1e-42 139.0 In-house 11-258 (267) alignment
Range on Protein: 617-875
Range on HMM: 11-258/267.0
EFQRLNSVTSREIPaEEKSVGEEpqNLHKNRFSDIIALNSCRVMLHNEHADeesdYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVML
||. .. ... .     .|..|.  |  .||. | .  .  ||.| ..  .    |||| ...... .||||.|| ||  |. ||. ...|... .||.|
efelikkisdtsst.isqsiaek..nqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivll

NNLHEldQEYPQYWPDH--GATKYGHIGVSVLSKQEKGDVICTKLKVTRKKvrRKTQEVCHLHHVSWPDK--CIPELAcSVLDLLdeaQTSQQQCGNAPV
 .  .  .. ...|| .   | ||  . |    ..|. |     |..  |.    ...|   ..  |  .    | |   .. .|      | . || |.
tkvft..dnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfkn..esahnvtlyyykkwnintnnkpylk.plfgil...aknqlengnrPl

LVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKY
.|.||.||||||||  | | |||.|||.| |.|. ...||   .| |..  .|....... .|
vvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey

subfamily_PTPN1_pd Subfamily PTPN1 633-872 4.3e-42 138.8 In-house 23-267 (290) alignment
Range on Protein: 633-872
Range on HMM: 23-267/290.0
EKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHAdeesDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQE-YPQYWP
. .. ..|.|  .||. |.   . .|..|....     ||||| ...... .  .| || || .||. ||.|| . .  ..||||.. | .|    ||||
ptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywP

DHG---ATKYG--HIGVSVLSKQEKGDVICTKLKVTRKKVrRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQC-GNAPVLVQCSNGVGRSGT
 .    . ..   .. | ..|...|   .  .|... .|  ..|.|. | |...|||  .||   . |..| . . |        |... || |.|||||
qgeeekellledtklkvkliseerksyytvrllelenlkt.qetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGt

FCAISSVLERLKTEQ---VIDVFQVIKRIRVNLPGAVESPTQYLFCYQII
|| . ..| ... ..    .|. .|.  .|    | .  . |  | |. |
fclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylai

0046846 (Phosphotyrosine protein) phosphatases II 372-581 6.7e-42 138.5 In-house 6-171 (176) alignment
Range on Protein: 372-581
Range on HMM: 6-171/176.0
VNGDEDSDYINASFIHGYDgtprsFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDkIETYGGvtvtlhqseifadyeirtfils
   |.|.|||||..| |.      .|| |||||  .. |..|..|.. . .|.||..||||. ||. |||. .|..|                       
lgldldldyinanlilgsr.....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe.leklgi......................

kakrsgsrmvrQFHFTVWPDKGVPQYaTAVLAFRRKVRALNPRDaGPVIVHCSAGVERTGTYIVIDAMLEqakkSRTVDIRNYLIALRKDRP-HMVQTKE
           |.... ||| |||.. ...| . . .|    .. |||.||||||. ||||..... .      .. ... . |  .|. || ..||| |
...........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpe

QYSFIHSAVLE
|| |.. ..|.
Qyrflyefell

0036282 (Phosphotyrosine protein) phosphatases II 670-870 6e-41 135.4 In-house 2-164 (174) alignment
Range on Protein: 670-870
Range on HMM: 2-164/174.0
SDYINAVFLHAHRGRNAFIATQHPLLetvedFWRMVTDYDIGTIVMLNNLHELD-QEYPQYWPDhgatkyghigvsvlskqekgdvictklkvtrkKVRR
|||||| .|. ..  . .||.|.||      ||.|. ...| |.|||....||.    ..|||.                                .   
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lred

KTQEVCHLHHVSWPDKCIPELACsVLDLLDEAQTSQQQCGNAPVLVQCSNGVGRSGTFCAISSVLERLKtEQVIDVFQVIKRIRVNLPGAVESPTQYLFC
 .......... ||| . |.|.  .|........ ...... |||| || ||||.||..|.  .| .|. | ..|........|   ||.|..| || |.
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfl

YQ
|.
yy

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 631-872 1.1e-40 134.3 In-house 34-232 (392) alignment
Range on Protein: 631-872
Range on HMM: 34-232/392.0
AEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDqeypqyw
. ...|.... ||.|||. .|. ..| ||.|       .|||.|| ....    .|.||.| |   ...|||||| . .. ||.|...|.| |       
iypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.......

pdhgatkyghigvsvlskqekgdvictklkvtrkkVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQCGnAPVLVQCSNGVGRSGTFCAIS
                                      ... |.  | . |||| .|. ..|.| .. | ..   |    |....|| ||||.|   .| 
...................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqyt.hpliihcsagvgrtgvvisid

SVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQII
||. . |. ...|||...  || . |  |..  || | |  .
svvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygav

subfamily_PTPN14_pd Subfamily PTPN14 622-877 1.2e-40 134.4 In-house 30-297 (300) alignment
Range on Protein: 622-877
Range on HMM: 30-297/300.0
NSVTSREIpAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADeESDYINAVFLHAHRG--RNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNL
. .. ..    . |... |.| .|||| |..  . .|| |   . . ...||||  ...  |  .  .|..| ||  ||.|||.|| . ..  |||| . 
eripkkre.dallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmltee

HELDQE-YPQYWPDH----GATKYGHIGVSVLSKQEKGDVICTKLKVTRKKvRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQ--------Q
.|  .|   .|.|..       ..|.  |.   ... . || |.||.      .. ..| || .. |||. .||   . |. |.| |  ..        .
eedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlp.skeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnsevesk

CGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFD
  . |||| ||.||||.|       ... |.....||. .|..|.|      |.. .|| | |... ||..
eskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk

0043147 (Phosphotyrosine protein) phosphatases II 374-576 2.3e-40 133.5 In-house 1-154 (172) alignment
Range on Protein: 374-576
Range on HMM: 1-154/172.0
GDEDSDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLvelgktkchkywpdkietyggvtvtlhqseifadyeirtfilSKA
|||.|||||||....|  ..| ||| ||||.  .. ||||..|.. . ||.||.|                                           . 
gdegsdyinasyldlyyipdr.fiatqgplrntladfwrmlkelgithivnltel..........................................lyd

KRSGSRMVRQFHFTVWPDKGVPqYATAVLAFRRKVRA-LNPRDAGPVIVHCSAGVERTGTYIVIDAMLeqakksRTVDIRNYLIALRKDRPHMVQTKEQY
.   .|.. |.... ||| |||  .  .| | . ..  |. .. |||.||||||| |||| .... ||      . ... . .  .|. ||..||...||
pellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqy

SFIH
 |..
rfly

0041856 (Phosphotyrosine protein) phosphatases II 642-875 2.4e-40 133.4 In-house 1-170 (182) alignment
Range on Protein: 642-875
Range on HMM: 1-170/182.0
NLHKNRFSDIIALNSCRvmlhnehadeESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNnlheldqeYPQYWPDHGatkyghi
||.|||.|||.  .  |           .||||| ..   .  . |||||.|||.||.||.||. ...|.|||.|.         ..|||..        
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt........eelywpell.......

gvsvlskqekgdvictklkvtrkkvrrkTQEVCHLHHVSWPDKCIPElACSVLDLLDEAQTsqqqcGNAPVLVQCSNGVGRSGTFCAISSVLERlkteQv
                            ...........||| ..|.   ..||...|..       . |||| || ||||.||..|.  ....    . 
............................erlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.

IDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKY
.......| .|   ||.|..| || |.....  .
vsleeavklvrsrRpgmvitpnqyfflqlallel

0049772 (Phosphotyrosine protein) phosphatases II 602-883 1.5e-39 131.9 In-house 6-287 (314) alignment
Range on Protein: 602-883
Range on HMM: 6-287/314.0
LASVNRKFQMTGYALEFQRLNSVTSREIPAEEKSVGEEPQNLHKNRFSDIIALNsCRVMLHNEHADEeSDYINAVFLHAHrgrNAFIATQHPLLETVEDF
|||...  ..  .  ....||... . .|.    |.  . | .|||. ||.  . .||.|.... .  |||||| ... .   ..|||||.|| .||.||
lasfsellihddllklllvlnrrslsvlpeltilvadlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdf

----------WRMV--TDYDIGTIVM---------------------LNNLHEL-DQEYPQYWPDHGatkyghigvsvlskqekgdvictklK-------
          ||||   |... .|||                     |..| .. ..  .......                          .       
reepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgngneptaadlellk.........................eelydpel

VtrkkvrrkTQEVCHLHHVSWPDKCIPeLACSVLDLLDEAQTSqqqCGNAPVLVQCSNGVGRSGTFCAISSVLERLKteqViDVFQVIKRIRVNLP----
.        .... ..... .|| . | |   ....|.  ..      . |||| |. |.||.|||...  .. .|.   | .. ......|   |    
f........erlgikylripvpDgsap.lledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllg...v.sleealedvrlkRpinpn

-GAVESPTQYLFCYQIIQKYFDSFSDYA
 |..|.. ||.|.......|.. . .. 
pgfieqleqyefilealleylkflkkfy

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 350-581 5.6e-39 128.7 In-house 33-257 (267) alignment
Range on Protein: 350-581
Range on HMM: 33-257/267.0
NKNKNRYANIVAYDHSRVVLERVNGDedsdYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNlveLGKTKCHKYWPDK---IET
|...||. . . ||..||.|   . .    |||||...||  | . ||. |.||  .   |. .. .|.   ||.||.    .. . ...|| |    . 
nqernrlddnlpyddtrvilrtkeee....yinasyvegyk.tknafivtqdplkntitdfltvihdqkvpvivlltk...vftdnirlfwPPkmgqakk

YGGVTVTLHQSEIFADYEIRTFILsKAKRSGSRMVRQFHFTVWPDKG-VPQYATAVLAFRRKVRALNprDAGPVIVHCSAGVERTGTYIVIDAMLEQAKK
|  .||     .   ||.| |. | | |   .. |  ...  |  .     |   ...   | .  |     |..|.||.|| |.||..|||..||.||.
yqdltvehslekeendyqiitlel.kfknesahnvtlyyykkwnintnnkpylkplfgilaknqlen..gnrPlvvacsdGvGrsGtflvidsqlerakt

SRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
  ..|| ..|  .|. |. .|.|||.| .||  . |
egvsdifdflrkirsqriglvdtkeryiyihellae

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 349-581 7.9e-39 128.1 In-house 54-287 (305) alignment
Range on Protein: 349-581
Range on HMM: 54-287/305.0
ANKNKNRYANIVAYDHSRVVLERVNgdeDSDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP----DKI
 .. ||||... . |.| | |.. .    |||| | ..       . ||..||||  . . || || ... . |||| . ||||| || .|||    .| 
iaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekl

ETYGGVTVTLH--QSEIFADYEIRTFILSKAKRSGSRM-VRQFHFTVWPDKGVPQYATAVLAFRRKVRAlnprDAGPVIVHCSAGVERTGTYIVIDAMLE
|  .|. |        .  | ||.  .|  .   . .| ||....| |||.|||    . | .   .|        |..||||||. |||| . |. .||
elksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairg....skvpivvhcsagigrtgtivaieyile

QAKKSR-TVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
.  . .    . . . ||| .| . .|.  || |||  .|.
kiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln

0049260 (Phosphotyrosine protein) phosphatases II 393-576 8e-39 128.1 In-house 8-143 (152) alignment
Range on Protein: 393-576
Range on HMM: 8-143/152.0
PRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWpdkietyggvtvtlhqseifadyeirtfilskakrsgsrmvrQFHFTVWPDK
|. ||| |||.|  .. ||||..|.. . |||||.|.|||| ||..|.                                          |.... ||| 
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................................qylhlpwpDh

GVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVERTGTYIVIDAMLeqakksRTVDIRNYLIALRKDRPHMVQTKEQYSFIH
|||. .  .| . . .. |. .. |||.||||||| ||||..... ||      . |.. ...  .|. ||..|....|. |..
gvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 641-872 8.3e-39 128.2 In-house 2-235 (237) alignment
Range on Protein: 641-872
Range on HMM: 2-235/237.0
QNLHKNRFSDIIALNSCRVMLHNEHADeeSDYINAVFLHAHRGR-NAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQE-YPQYWPDHG-ATK
.|  |||...|.| . .||.|.   ..  |||||| .|.   |  . .||.| ||  . .|||.|| .     ||||  | | ...   .|||.    . 
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGHIGVSVLSKQEKGDVICTKLKVTRKKVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQ-TSQQQCGNAPVLVQCSNGVGRSGTFCAISSVLERL
|| . ||.  |.|  |     | ....   .. . .   .  ||||. .|. ....| .  .    |.     .| .. || ||||.| |  | ..| . 
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

KTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQII
| ..|.|... .. |  . |  ...  ||.| .| |
kekkvvdiynyvysieedrpyiiqtkdqyvfihqti

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 596-877 1.2e-38 127.4 In-house 11-284 (290) alignment
Range on Protein: 596-877
Range on HMM: 11-284/290.0
NQAMQKLASVNRKFQMTGYALEFqrLNSVTSR-EIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEhadEESDYINAVFLHAHrgRNAFIATQHPL
 .|..|.||   | .. ..| |.  |. .         |... ..  ...|||. |..  .  ||.|..     . ||. | ...    .  || || .|
teafekfasdvvkknvdelakey..leklkpylpvqylerkifdkntefkknrykdvvcndktrvilkdG...ydGdyvhanyvkGl..kamfiltqGal

LETVEDFWRMVTDYDIGTIVMLNNLHELDQ-EYPQYWPDHG--ATKYGHIGVSVLSKQEKGDVICTKLKVTRKKVRRKTQEVCHLHHVSWPDKCIPELAC
 .|| |.|||| . .. .|||| .| |  .    ||.|..   .  .|.| |    ...| . |  |.   |.|   |   . ||. .|||||...  . 
kdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstl

SVLDLLDEAQTSqqqCGnaPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFD
..| .|   ..     |  || | || |.||.||| ||   |. |   . .|. .... .|    ..|.  .|||   .|. ..  
allrtlrilrka...sG..pvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGk

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 642-869 1.5e-38 127.3 In-house 8-234 (239) alignment
Range on Protein: 642-869
Range on HMM: 8-234/239.0
NLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGR-NAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELD-QEYPQYWPDHgATKYG
|  |||...|.. .  ||.| .   |  |||||| .|. . |  .|.||||  .  .  |||||. .     ||||  | |   ..  |||||  ..|| 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.tskyc

HIGVSVLSKQEKGDVICTKLkVTRKKVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDeAQTSQQQCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTE
 . |..   .   | |   . |  .  . . . | . |   |||| .|. | .|| |     | .   |  | ...|| ||||.|.|  | ..| . | .
nlrvtlrktevfadyiirtf.vmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrr.kitkdslpgarpwvihcsagvgrtgaflvidamlrqakkq

QVIDVFQVIKRIRVNLPGAVESPTQYLFCY
. .|.|. .| || . |  |..  ||.| .
ktvdifnyvkairedrphmvqtseqyvfih

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 642-869 1.5e-38 127.3 In-house 7-233 (239) alignment
Range on Protein: 642-869
Range on HMM: 7-233/239.0
NLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGR-NAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELD-QEYPQYWPDHgATKYG
|  |||...|.. .  ||.| .   |  |||||| .|. . |  .|.||||  .  .  |||||. .     ||||  | |   ..  |||||  ..|| 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.tskyc

HIGVSVLSKQEKGDVICTKLkVTRKKVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDeAQTSQQQCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTE
 . |..   .   | |   . |  .  . . . | . |   |||| .|. | .|| |     | .   |  | ...|| ||||.|.|  | ..| . | .
nlrvtlrktevfadyiirtf.vmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrr.kitkdslpgarpwvihcsagvgrtgaflvidamlrqakkq

QVIDVFQVIKRIRVNLPGAVESPTQYLFCY
. .|.|. .| || . |  |..  ||.| .
ktvdifnyvkairedrphmvqtseqyvfih

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 325-582 1.6e-37 123.9 In-house 22-286 (305) alignment
Range on Protein: 325-582
Range on HMM: 22-286/305.0
IRLENEY---KKFNNGQQFpwEAARKPANKNKNRYANIVAYDHSRVVLervNGDEDSDYINASFIHGyDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQS
. | .|.   |.||. ...  .| ..  ...|||| ..   |. || |   .|    .|| | ..      |. || .| ||  .   || | .... ..
aglraefvamkrfndfekm..kafkeaqeagknrykdvgcldnnrvkl...egpwpheyihanyvst.ptnpkrfictqaplektcadfwymclqdkvea

IVMLTNLVELGKTKCHKYWPDKI-------ETYGGVTVTLHQSEIF-----ADYEI-RTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKV
| || ||.| |  ||..|.. |        |    ..| .  |. .     |. .. .| .. .   . .| | ..|.  |||.|||   .|.| .  | 
ifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelleka

RALNprdaGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRN-YLIALRKDRPHMVQTKEQYSFIHSAVLEA
|..     ||..||||||. |||. .... .|.|    . ..  .  |  .|..|   .|| .|| |.|  .|. 
rpsk....gpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilny

0046846 (Phosphotyrosine protein) phosphatases II 664-877 1.9e-37 124.0 In-house 6-174 (176) alignment
Range on Protein: 664-877
Range on HMM: 6-174/176.0
EHADEESDYINAVFLHAHRgrnaFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQEY-PQYWPDhgATKYGHigvsvlskqekgdvictklkvt
 . |. .||||| ..  .|    .||||.|| .|..||..|. ...|...|.|....||..   |.|||.   .|.|.                      
lgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi......................

rkkvrrktqevcHLHHVSWPDKCIPELaCSVLDLLDEAQTSQQQcgNAPVLVQCSNGVGRSGTFCAISsvleRLKTEQVIDVFQVIKRIRVNLP-GAVES
            . .|. ||| ..|.|   .|.||.. .. ...  . |||| || |.||.||..|.      |..|. ..|.......|   | |||..
............qylhlpwpDhgvpdl.elllellefirealke..ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqt

PTQYLFCYQIIQKYFD
| || |.|. ......
peQyrflyefellllk

0044763 (Phosphotyrosine protein) phosphatases II 362-580 3.3e-37 123.2 In-house 2-168 (178) alignment
Range on Protein: 362-580
Range on HMM: 2-168/178.0
YDHSRVVLERVNGDEDSDYINASFIHGYdgtprSFIASQGPlppafEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKIEtyggvtvtlhqseifa
.|..||.|. . | | |||||||.| ..      ...|..|     . ......|.. ..||.||. .|||. ||..|||.. .                
ldrtrvllsnleglersdyinaseilpg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

dyeirtfilskakrsgsrmvRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVERTGTYIVIDAMLEQakksrTVDIRNYLIALRKD
                     |.... .|| |||.    .|.| . .... ... |||.||||||| |.|| .... |...      ... . .  .|. 
....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrer

RPhMVQTKEQYSFIHSAVL
|| .|.. .|. ...   |
Rp.ivpnpgqlrqLyefel

0043147 (Phosphotyrosine protein) phosphatases II 667-870 4.3e-37 122.8 In-house 2-155 (172) alignment
Range on Protein: 667-870
Range on HMM: 2-155/172.0
DEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLheldqeypqywpdhgatkyghigvsvlskqekgdvictklkvtRKKV
|| |||||| .|. ..  . ||||| || .|..|||||. ...|..||.|..|                                            .  
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydp

RRKTQEVCHLHHVSWPDKCIPeLACSVLDLLDEAQTSQQQCGNAPVLVQCSNGVGRSGTFCAISSVLerlkteQVIDVFQVIKRIRVNLPGAVESPTQYL
   ...........||| . | |.  .|..|.  .. .... . |||| || ||||.||..|.  .|      . ........ .|   ||||..| || 
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyr

FCYQ
|.|.
flyy

subfamily_CG42327_pd Subfamily CG42327 348-509 9.8e-37 121.3 In-house 26-191 (319) alignment
Range on Protein: 348-509
Range on HMM: 26-191/319.0
PANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK----
.. |.|.|..|.|   ..||||.|.  |. . |..||.. ||| .| |.||.| .|  .   |||.||||.|. || ||.| |||  .| .|.| |    
vtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketld

-IETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFtVWPDKGVPQYATAVLAFRRKVR
  ..|| . ||| . |.   | | |..| . ... || .  . .  |.. .||   .|..|   .||
ntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevr

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 627-878 1.3e-36 120.9 In-house 24-279 (287) alignment
Range on Protein: 627-878
Range on HMM: 24-279/287.0
REIPAEEKSvGEEPQNLHKNRFSDIIALNSCRVMLHNEhADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVML-NNLHELDQE
.  .|  |.  ||  . .|||..|.. ..  ||.| .| ..  |||||| .. ...  .||||.| |.  || ||||.| .    .....  .. |  ..
esstatfka.aeelaavkknryadvlPiddtrvllsae.gelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlk

YPQYWPD-HGATKYGHIGVSVLSKQEKGDVICTK-LKVTRKKvRRKTQEVCHLHHVSWPDKCIPEL----ACSVLDLLDEAQTSQQQCGNAPVLVQCSNG
  .|||. .   . |   | .|... |    ... |..   .  |... |  |. .||||| ..      .  |||  .  . ...  .  |..| .. |
cykywPerevPmrvGGysvvlldydikePeygvralrlidle.trearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvG

VGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFDS
.||||.. |.  ...||.    .|| .|. |.|    . | .. |. . |. .  |. .
iGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyykt

subfamily_ptpA1_pd Subfamily ptpA1 347-541 8.3e-36 118.6 In-house 44-254 (418) alignment
Range on Protein: 347-541
Range on HMM: 44-254/418.0
KPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGydGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKIET
|  | .||||.||.  .|.|| |....  | |||||| .| |    |. ||..||||| .   |||||||.  . ||||.   |  . || .|||..|  
kkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg..aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigg

-----YGGV-----TVTLHQSEIFAD--YEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAF-----RRKVRALNPRD-AGPVIVHCSAGVE
     ||       | ..   |.  |   || |  .  .    .| . |...  |||. .|...  .  .      |. . .   |   |.|||||||| 
eqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvg

RTGTYIVIDAMLE
||||.     |..
rtgtfctavimmk

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 327-587 1.9e-35 117.3 In-house 21-275 (288) alignment
Range on Protein: 327-587
Range on HMM: 21-275/288.0
LENEYKKFNNGQQFPwEAARKPANKNKNRYANIVAYDHSRVVLErvngdEDSDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLT
|. ||.   |. .    .    ||  ..|| |.   | .|| |.     .|.|.  |. .      .| .| .| ||  . | .|.|. |.. . ||||.
lkkeyrdspneasid.iidsfianptrdryenlprcditrvkls.....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlc

NLVELGKTKCHKYWPDKIETY---GGVTVTLHQSEIFADYEIRTFILSKAKRSGSRM-VRQFHFTVWPDKGVPQYATAVLAFRRKVRALNprdaGPVIVH
.|.|.|| |  .|.| |.      | .     ..    |  ..  .|   |    .. |.. |.  |.|.|||.   . | .   ...|.     |..||
ellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslq....kPivvh

CSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGN
.|||| |||| |.|  .||... .  . ||. |  ||..| . .||. || ..|  ||| |    
ssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelllkk

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 346-581 1.2e-34 114.3 In-house 33-267 (281) alignment
Range on Protein: 346-581
Range on HMM: 33-267/281.0
RKPANKNKNRYANIVAYDHSRVVLER-VNGDEDSDYINASFIHGyDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKI
 .| |..||||.|| . | ||| |.  .   . .||| | .|.      | .| .|||   .   ||||.|..|. .|||| ...|  . || .|.| . 
nqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirs.pflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprna

ET---YGGVTVTLHQSEIfaDYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRAlnpRDAgPVIVHCSAGVERTGTYIVIDAMLE
     .  ..|.  .| .  .  . |  |  .    .|.. .. .  |||  ||. .  .|   ||.||   | . | ..|||||| |.|| . ..  |.
hcclqfdklsvsyedstv..nkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkira...rst.ppvihcsagvgrsgtlmaveialq

QAKKSRTV-DIRNYLIALRK-DRPHMVQTKEQYSFIHSAVLE
  .   |. ||.. .  ||   |   ||| .|| .|   .|.
sihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 328-592 2.6e-34 113.2 In-house 30-298 (310) alignment
Range on Protein: 328-592
Range on HMM: 30-298/310.0
ENEYKKFNNGQQ--FPWEAARKpaNKNKNRYANIVAYDHSRVVLErVNGDEDSDYINASFIHGyDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVML
 ..|.|..  |.  . .|| .|  .  ||||...|  | ||| |. ..     ||| | ...  .    .|| |||||  .   ||||.... ..||..|
vkqyrkldakqdssltyeaykk..ymhknrysdvvcldtsrvklk.idksryedyihanyvkt.nylrstficsqgplqhtiidfwrmifqeraesilll

TNLVELGKTKCHKYWPD--KIETYGGVTVTlHQSEIFADYEIR----TFILSKAK------RSGSRMVRQFHFTVWPDKGVPQYATAVLAFrrkvRALNP
 . .| |. ||  |||     |||| . ||   ||   ..||     ||.  .              |   ..  |||.|||.     .      | |  
ckvgeegrpkcvgywpslgvtetygcirvt.nlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpq....rllaq

RDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLeALTCGNTEIQS
   ||..||||||..|... . ..  ......   ||. .    |.|.|   .||. || .|.   . ... |.||.  
vrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvri.ifargetevae

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 640-876 5e-34 112.7 In-house 39-277 (307) alignment
Range on Protein: 640-876
Range on HMM: 39-277/307.0
PQNLHKNRFSDIIALNSCRVMLHNEHAdeESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ-EYPQYWPDHGATK-
  | .|||..|. . . .|.... . .   |||| | .|      . ||..| || .|. .|| |. . .. ...|| .. || .    ||||     | 
santdknryqdvkcqdkgrivvkfdgl..asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqkl

-YGH----IGVSVLS-KQEKGDVICTKLKVTRKKVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQqqcgnAPVLVQCSNGVGRSGTFCAISS
 .|.    | |. |  |.   |  . ..   . .  .|.. . ||    |||. .|..  . ..||.  .  .      ||.| || |||||||  ||| 
vfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydt.....npvvvhcsaGvGrsGtivaisl

VLERL-KTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYF
| ... . .   |. .... .| . . |...  |||. .... .||
vqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf

0051082 (Phosphotyrosine protein) phosphatases II 377-580 6.4e-34 112.1 In-house 2-150 (151) alignment
Range on Protein: 377-580
Range on HMM: 2-150/151.0
DSDYINASFIHGYdgtprsFIASQGPLPpafeGFWRMVWEQNSQSIVMLTNLVELGktKCHKYWPDKIetyggvtvtlhqseifadyeirtfilskakrs
 |||||.|.. |.      ...|.|||.     |.....|.. ..||.|....| |  .|..|.|.                                  
lsdyinfsyvtgg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg................................

gsRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRAlnpRDAGPVIVHCSAGVERTGTYIVIDAMLEQakksrtVDIRNYLIALRKDRPHMVQTKEQYSFIH
  . |...... ||| |.|..  |||.| .....    . |||.||||||. |||| .... ||..      |..   |  .|. ||..||...|. |..
..ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfql

SAVL
 |.|
fall

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 350-587 6.8e-34 112.0 In-house 43-280 (312) alignment
Range on Protein: 350-587
Range on HMM: 43-280/312.0
NKNKNRYANIVAYDHSRVVLervNGDEDsDYINASFIHGYdGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKIE----
 |. ||| ||  .|  |  |    |||.  || | |..     |  |...||||  .   ||...    | ||..|. .|| |  || ||  | .     
fkdlnrypniqcwdrgrftl...agden.fyihanfvkic.tkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdl

-TYGGVTVTLHQSEIFADY--EIRTF---ILSKAKRSGSRmVRQFHFTVWPDKGVPQYATAVLafrRKVRALNpRDAGPVIVHCSAGVERTGTYIVIDAM
  .   |    . ||       |      .. ||    |. . .. .. |||.|.|.   . |   | . |.. .|  ||| |||||| |||| ..|..|
edhrvyteycteieiggkskdkithrvlkvvvkatgqesk.lnhyqwaswpdhgmpdscdtal...rllsavk.kdkkpviahcsagvgrtgtlaliesm

LEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGN
.   .. |  .... .. |||||   |..  || .   .||| | .  
iaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskg

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 640-876 9.6e-34 111.7 In-house 41-271 (288) alignment
Range on Protein: 640-876
Range on HMM: 41-271/288.0
PQNLHKNRFSDIIALNSCRVMLHnehaDEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQEY-PQYWPDHG--AT
 .|  ..|. ..   . .|| |.    |.   ||.|  . ... .. .| .| ||  |.| .|.|. . |.  ||||..| |. .|   .|.| .   ..
ianptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGeka

KYGHIgvSVLSKQEKgDVICTKLKVTRKKVRRKTQE---VCHLHHVSWPDKCIPELACSVLDLLDEAqtsqqQCGNAPVLVQCSNGVGRSGTFCAISSVL
..|..      |... . |   .||.  .. ....|   | .||   |.|...||   | | ||.       .  . |..|..|.||||.||.  |  .|
rigrl..ctvvkkkr.adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililial

ERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYF
| |. .  . . ..... | .   |...  |||. .... ...
eslrlddflgirsllaklreerfkaiqtemqylyvhrcvleel

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 335-508 1.8e-33 110.7 In-house 18-193 (297) alignment
Range on Protein: 335-508
Range on HMM: 18-193/297.0
NNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNgdEDSDYINASFIHGY-DGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGK
.. .   . .|....   |||| .|.|.| .|| | ||    ..||||| ..    . ..  .| .||||  . . ||..|.||. . |||...| | |.
deargesfssakrnsslrknryrdilatddtrvkllrvi..terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGr

TKCHKYWPDKIET--YGGVTVTLHQSEIFADYEIR-TFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKV
 ||  |||.  .     |  |  . |.   ...      |    || ||.||   |  |||.|||     .  |. .|
dkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqv

PTPc_DSPc_SM00012 481-581 5e-33 108.8 In-house 2-105 (105) alignment
Range on Protein: 481-581
Range on HMM: 2-105/105.0
VRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDA--GPVIVHCSAGVERTGTYIVIDAMLEQAKKS-RTVDIRNYLIALRKDRPHMVQTKEQYSFIHS
|...|.| |||.|||......| . |.|.  .   .  .||.||||||| ||||....| .|.| .|. ..||| ... .||| ||.||||.|||.|.. 
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AVLE
|.||
alle

0049260 (Phosphotyrosine protein) phosphatases II 681-870 5.6e-33 109.1 In-house 5-144 (152) alignment
Range on Protein: 681-870
Range on HMM: 5-144/152.0
HRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQE-YPQYWpdhgatkyghigvsvlskqekgdvictklkvtrkkvrrktqevcHLHHV
..  ..|||||.|. .|..|||||. ...|.|||||..|.||. .  .||.                                            . .|.
yampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................qylhl

SWPDKCIPELACSVLDLLDEAQTSqQQCGNAPVLVQCSNGVGRSGTFCAISSVLerlkteQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQ
 ||| . |.|.  .|.||.  .   ..  . |||| || ||||.||..|.  .|      . ..........|   ||||..| |. |.|.
pwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 627-873 3.1e-32 106.6 In-house 18-292 (297) alignment
Range on Protein: 627-873
Range on HMM: 18-292/297.0
REIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNehADEESDYINAVFLH--AHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ
.|  .|. |.   .  |.|||. ||.| .. || | .  .  |.||||| ..          .| .| || .||.|||..|.. |...|||. .| |  .
deargesfssakrnsslrknryrdilatddtrvkllr..viterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGr

E--YPqYWPD--HGATKYGHIGVSVLSKQ--EKGDVICTKLKVTRKkvrRKTQEVCHLHHVSWPDKCIP----EL------ACS-------VLDLLD---
.  .| |||.   .  | |.. |  ||.   |   || |.|..  .    ... | |  ..||||. .|    .|       ||       .| |..   
dkcap.ywpsvvqerlkagdvvveflsstsdefdrviltelqliyr...sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemft

-----EAQTSQ-QQCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQ
     . .. . ..  ||..|| || ||||||       .|..|. ... ||  ... .| . .  |..  |. ..|... 
amvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavl

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 477-613 3.7e-32 106.2 In-house 87-224 (440) alignment
Range on Protein: 477-613
Range on HMM: 87-224/440.0
GSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALN-PRDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFI
 || ..|.|.  |||||||..|  || . . |   .     ||..||||||. |||  |..|..| .||.|  .|| ... ..|..||.|||| |||.|.
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

HSAVLEALTCGNTEIQSETYNQAMQKLASVNRKFQMTG
| ||||.| ||.| |  .   . ....   | . . . 
heavlegllcgdtliledditerveqiqwpnphtdksp

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 348-583 1.8e-31 104.1 In-house 33-270 (285) alignment
Range on Protein: 348-583
Range on HMM: 33-270/285.0
PANKNKNRYANIVAYDHSRVVLErvngDEDSDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKIE--
 || . ||||.. . . .||||.    . | ||| ||...       ..|..||||| ..  ||.|.....   ..||  |.| |  ||  |.|.|.   
eanpdlnryadvrcieetrvvlk....nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgev

-TYGGVTVTL--HQSEIFADYEIRTFILSKAKRSGSRMVRQFH--FTVWPDKGVPQYATAVLAFRRKVRALNPRDAgPVIVHCSAGVERTGTYIVIDAML
  .|   .||   . |  |   . .. . ... . |  .   |     |||.  |. |  .. . . |. .||..  |. ||||||| || |.. ||   
vkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkek.picvhcsagvgrtatfvgidyat

EQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
 .  .   ... . .  .|  | . ||.. |. |..  ..| .
irimenpniemldivremramrfqavqshmqflflyvvlmeyf

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 638-877 1.8e-31 104.0 In-house 44-288 (305) alignment
Range on Protein: 638-877
Range on HMM: 44-288/305.0
EEPQNLHKNRFSDIIALNSCRVMLHNEHAdeeSDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELD-QEYPQYWPDH--G
 | |. .|||. |.  |.  || |..       .|| | .. .    . || || || .|  ||| |  .  . .| || || |   .   .|.. .   
keaqeagknrykdvgcldnnrvklegpwp...heyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkd

ATKYGHIGVSVLSKQEKGDVI----CTKLKVTR-----KKVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQqqcgnAPVLVQCSNGVGRSGT
  ..   |  .  | |    .     .| |||.     .    |.. | | | . |||. .|    ..|.|| .|..|.      |. | || |.||.|.
vlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpsk.....gpivvhcsagigrtgs

FCAISSVLERLKTEQVID-VFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFD
   .  .|..| . |.|.   .....|| .   .... .|||| .|.| .|| 
vvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 681-871 1.9e-31 103.8 In-house 1-199 (199) alignment
Range on Protein: 681-871
Range on HMM: 1-199/199.0
HRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ-EYPQYWP--DHGATKYGHIGVSVLSKQEKGDVICTKLKVTRKK-VRRKTQEVCHL
|.|.  .||||||| ||. |||.|| .   | |||.|.     . .|| |||  . |..||| . |.. .   | |   | | .| .      |.|. | 
hkgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishy

HHVSWPDKCIPELACSVLDLLDEAQTS--QQQCGNAPVLVQCSNGVGRSGTFCAISSVL---ERLKTeQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQI
   || .|  |..|  |  ..   . |   .|  .|||.|.||.| | .| | |.   .   |  ||  |.|.|.| ||.|    | . |  .| | ||.
qftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfiyqv





subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 683-871 7.3e-31 101.9 In-house 2-198 (198) alignment
Range on Protein: 683-871
Range on HMM: 2-198/198.0
GRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ-EYPQYWP--DHGATKYGHIGVSVLSKQEKGDVICTKLKVTRKK-VRRKTQEVCHLHH
|.  .||||||| ||. |||.|| .   | |||.|.     . .|| |||  . |..||| . |.. .   | |   | | .| .      |.|. |   
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

VSWPDKCIPELACSVLDLLDEAQTS--QQQCGNAPVLVQCSNGVGRSGTFCAISSVL---ERLKTeQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQI
 || .|  |..|  |  ..   . |   .|  .|||.|.||.| | .| | |.   .   |  ||  |.|.|.| ||.|    | . |  .| | ||.
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfiyqv

PTPc_DSPc_SM00012 773-873 1.6e-29 97.6 In-house 2-104 (105) alignment
Range on Protein: 773-873
Range on HMM: 2-104/105.0
VCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQCG-NAPVLVQCSNGVGRSGTFCAISSVLERLKTE-QVIDVFQVIKRIRVNLPGAVESPTQYLFCYQ
| |.|. .|||...|| . |.|.||.. ........ ..||.|.||.||||.|||.|.. .|..|..| . .|.||..|..|   ||.|.. .||||.|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

IIQ
...
all

0051082 (Phosphotyrosine protein) phosphatases II 670-872 5.9e-29 96.0 In-house 3-149 (151) alignment
Range on Protein: 670-872
Range on HMM: 3-149/151.0
SDYINAVFLHAHrgrnaFIATQHPlletVEDFWRMVTDYDIGTIVMLNNLHELDqEYPQYWPDHGatkyghigvsvlskqekgdvictklkvtrkkvrrk
|||||. ..  .     ......|     .||.... ...| |||.|....| .  .|.|.|..|                                   
sdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg.ycpeylpelg...................................

tQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTsqqqCGNAPVLVQCSNGVGRSGTFCAISSVLERlkteqvIDVFQVIKRIRVNLPGAVESPTQYLFCY
  ||.|.. ..|||  .|..  .||..|....     ..| |||| || |.||.||..|.  .|..      ........ .|   ||.| ...|.||..
.ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfql

QII
. .
fal

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 640-871 5.9e-28 92.3 In-house 50-285 (310) alignment
Range on Protein: 640-871
Range on HMM: 50-285/310.0
PQNLHKNRFSDIIALNSCRVMLHNEHADeESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQEY-PQYWPDHGATK-
 ...||||.||.. |...|| |. ...    ||| | ....   |..|| .| ||  |. |||||. .    .|..| .  |  .     |||  | |. 
kkymhknrysdvvcldtsrvklkidksr.yedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtet

YGHIGVSVLSKQEKGDVICT--------KLKVTRKKVRRKTQEVCHLHHVSWPDKCIPELACSVLdlldeAQTSQQQCGNAPVLVQCSNGVGRSGTFCAI
|| | |. ||.  .   ||         .. |  .    |   |  ..   |||. .|.  |  .      |    |    |..|.|| |..| .. .|.
ygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtv.....pqrllaqvrhgpcvvhcsagkdrlyvvval

SSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQI
   ...|.  . .|. .|.  .. .    .... |||.  ..
klkidkldrglkvdaeevktellksraiciqtelqyliidrv

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 350-602 6.1e-28 92.4 In-house 50-299 (301) alignment
Range on Protein: 350-602
Range on HMM: 50-299/301.0
NKNKNRYANIvAYDHSRVVLERVNGDedSDYINASFIHGYdGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKIET---
.|.|.|| ..   . |  |   |.|      | | .|    | |. |||.||||. . | || |.   . . ||||.. ||  ..||..| | ||.    
pkdkhryptv.PckPstavevivdGk..rvPihanwipts.GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekld

YGGVTVTLHQSEIFADYEI--RTFIL-SKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRalnpRDAGPVIVHCSAGVERTGTYIVIDAMLEQA
 |  .......|   . .|  ||. .   ...  .| |  . .. |.|.|||.  . .  .   |.    .   |..||||||. |. ..|  . .  . 
igrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvk....ksekPivvhcsaGiGrsvafigteylarev

KKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCgNTEIQSETYNQAMQKL
.  .|... . |  ||..| . |||..|  ..    .  |   . ...  .|.. .. .
eadptieltealkhlrehrwngvqtnsqlywmtlGtvyrlik.eygfdmkiyeeqlamf

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 642-876 1.8e-27 90.8 In-house 55-289 (305) alignment
Range on Protein: 642-876
Range on HMM: 55-289/305.0
NLHKNRFSDIIALNSCRVMLHNEHadeESDYINAVFLHAHR-GRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQ-EYPQYWPDHGATKYG
.  |||..|. . .   | |..      |||| | .. .     . ||..| || .|...|| || .  .  |||| .  || .    ||||     |  
aitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

-HIG--VSVLSKQ----EKGDVICTKLKVTRKkvRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQqqcgnAPVLVQCSNGVGRSGTFCAISSV
 . |  |  .|         ..  | |..|      ..  | ||.   |||. .|    . |.||   . |.      |..|.|| |.||.||  ||  .
lksgivvenvsgskpmerdaeiqitllnltys..gdqkmsvrhlqwtewpdrgvppckltslellsairgsk.....vpivvhcsagigrtgtivaieyi

LERLKTE-QVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYF
||..  . ..  . ...| .| .   ....  |||| .... .||
lekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 625-874 2.8e-27 90.1 In-house 20-267 (281) alignment
Range on Protein: 625-874
Range on HMM: 20-267/281.0
TSREIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEH-ADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELD
   . |..  .| ..| | .|||...| .|.  || |. .    . .||| | ....   .  .| || |  ||  |||||. . .  .|||| .. | .
lpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletn

QEY-PQYWPD--HGATKYGHIGVSVLSKQEKGDVICTKLKVTRKkvrRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSqqqcgNAPVLVQCSNGV
.|   .|.|   | . .. .. ||      .  .. |.|... .    .|. . |     |||  .|| .  .| .| . ..       .| ...|| ||
rekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsye...getrlithwlwkewpdwqvpessevmlkilrkirar.....stppvihcsagv

GRSGTFCAISSVLERLKTEQV-IDVFQVIKRIRVNLPG-AVESPTQYLFCYQIIQK
|||||. |.   |. ...     |. |.. ..||     .|..  ||.. ....  
grsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 642-876 3.5e-27 90.1 In-house 35-270 (285) alignment
Range on Protein: 642-876
Range on HMM: 35-270/285.0
NLHKNRFSDIIALNSCRVMLHNEhadeESDYINAVFLHA-HRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQEY-PQYWPDHG--ATK
|   ||..|. ...  ||.|.|     . ||| | ...   . ....|.|| || ||. |||.|. .  |  ..||  | |   |    |.|..     |
npdlnryadvrcieetrvvlknh....drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvk

YGHIGVSVLSKQEKG--DVICTKLKVTrkKVRRKTQEVCHLHHV---SWPDKCIPELACSVLDLLDEAQTSqqQCGNAPVLVQCSNGVGRSGTFCAISSV
.|.  ...   .|.     |   | |.  .    . |  .. ||    |||.  || |  ...|    .    .  . |. |.|| ||||. ||  |   
fgkyeitlteckeeaiagtilnaltvi..ntedasseplymnhvqvpwwpdqlapedarpmielykwvkkv..npkekpicvhcsagvgrtatfvgidya

LERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYF
  |.  .  |....... .|     ||.|  |.|| | .. .||
tirimenpniemldivremramrfqavqshmqflflyvvlmeyf

0044763 (Phosphotyrosine protein) phosphatases II 656-876 4.4e-27 90.3 In-house 4-171 (178) alignment
Range on Protein: 656-876
Range on HMM: 4-171/178.0
SCRVMLHNEHADEESDYINAVFLHAHrgrnaFIATQHPLletvEDFWRMVTDYDIGTIVMLNNLHELD-QEYPQYWPDHGAtkyghigvsvlskqekgdv
 .|| |.|    | ||||||..   .     ......|     .|..... ...|..||.|..  ||  .....|||.                      
rtrvllsnleglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag...................

ictklkvtrkkvrrktqevCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQCGnAPVLVQCSNGVGRSGTFCAISSVLERlkteQViDVFQVIKRIRVN
                   .. .|. .|| . |.|   .|....  .. ....|  |||| || |||||||..|.  ....    .. .....|...|  
...................iqylhipipDhgvpdllehflefvefieealdekg.gpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrer

LPgAVESPTQYLFCYQIIQKYF
 | .|..| |. ..|.. ....
Rp.ivpnpgqlrqLyefelrll

subfamily_ptpA1_pd Subfamily ptpA1 630-836 7.5e-27 89.1 In-house 35-256 (418) alignment
Range on Protein: 630-836
Range on HMM: 35-256/418.0
PAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRnAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHE-LDQEYPQ
   | | |.. .|  |||...|. .|  || |.. .  | |||||| ..     .  ||.|| || .|. |||||| .     ||||.   |    .  .
gpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk.qfictqgplpntiadfwrmvwenrcriivmlsresencrikcdr

YWPDH-GATKYGHI--GVSVLS--KQEKGDVICTKL-K-V---TRKKVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQC-----GNAPVL
|||.. |  ..     |  |.     |  .||     . .    |  .  .|... . ..  |||. ||. .  . .||      |.|       | |..
ywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpii

VQCSNGVGRSGTFCAISSVLERL
|.|| ||||.||||.   ....|
vhcsagvgrtgtfctavimmkkl

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 673-861 8.1e-26 85.5 In-house 78-266 (301) alignment
Range on Protein: 673-861
Range on HMM: 78-266/301.0
INAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHE-LDQEYPQYWPDHGATK--YGHIGVSVLSKQE--KGDVICTKLKVTRKKVR
| | .. ..   . ||||| || .| |||| |.. ||. .|||| .  | | .   .| | . . |   |   . . .|.   . ...  .|.|.    .
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

RKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQqcgnaPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVES
 .|. | |  ...|.|. .|.    . ||.. .. |..     |..|.||.|.||| .| .   .  ...... |.. . .|..| .   .|  
fatrtvthyqysewtdrgvPkshaelfdlmelvkksek.....PivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqt

subfamily_egg_pd Subfamily egg 637-878 1.2e-25 84.8 In-house 35-272 (307) alignment
Range on Protein: 637-878
Range on HMM: 35-272/307.0
GEEPQNLHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELdQEYPQYWPDHG--
  .  ||.| |   .   .|.|| |. ..     |.| |  .. .   | || .| || .||.||||||   ..  ||||.   |  .. . |||     
aasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes.erceyywpkaesd

ATK--YGHIGVSVLSKQEKGDVIctkLKVTRKKVRRKTQEVCHLHHVSWPDKCIPELAcSVLDLLDEAQTSqqqcgNAPVLVQCSNGVGRSGTFCAISSV
. .   | . .  |  ..| | .   ..||. |.    .|  .| |  .  .   ..  | | .|  ..         ||.||. .|| ...|. ||   
slvtvpGslrienlkvdskadpl...frvtklklvGgddeerflehwqgdvnnssdvy.splrvlrklrnl.....skpvvvqdilGvskaatlvaieia

LERLKTEQV--IDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFDS
|  |    .    | . .. .| . . .|||. .||| |...  .|  
llsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrd

0048076 (Phosphotyrosine protein) phosphatases II 447-580 1.4e-24 81.8 In-house 13-140 (145) alignment
Range on Protein: 447-580
Range on HMM: 13-140/145.0
YGGVTvTLHQSEIFADYEIRT-FILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDaGPVIVHCSAGVERTGTYIVIDAMLEqakk
.|... | .. | ..|. |.| . |.  ..  .|.. |.... ||| |||. .  .|.| . .... ... |||.||||||| ||||..... ||.    
lgslp.taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll....

sRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVL
 . |.. . |  .|. ||..|.. .|. |.. ..|
.lgvsleealelvrsqrpgavpnpgqlrflyefel

subfamily_egg_pd Subfamily egg 339-580 7.2e-24 79.0 In-house 29-267 (307) alignment
Range on Protein: 339-580
Range on HMM: 29-267/307.0
QFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELgkTKCHK
. . . | .  |..| |   .   | ||| ||  .|    |.| |  ..|       || .| ||  . . |||||.... | |||||  .|    .|. 
eislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkp.llnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..ercey

YWPDK----IET-YGGVTVTLHQSEIFADyeiRTFILSKAKRSGSRmVRQFHFTVWpdKGVPQYATAVLAFRRKVRALNpRDAGPVIVHCSAGVERTGTY
|||      . |  |.. ..  . .  ||     | ..| |  |.    . .   |  .|  .... |    | .| |  . . ||.|..  || ...| 
ywpkaesdslvtvpGslrienlkvdskad...plfrvtklklvGgd.deerflehw..qgdvnnssdvysplrvlrklr.nlskpvvvqdilGvskaatl

IVIDAMLEQAKKSRT--VDIRNYLIALRKDRPHMVQTKEQYSFIHSAVL
. |.  | .  .  .    ...    ||. |.  |..  .| |..  ||
vaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl

0048179 (Phosphotyrosine protein) phosphatases II 460-577 2.9e-23 77.6 In-house 25-139 (144) alignment
Range on Protein: 460-577
Range on HMM: 25-139/144.0
FADYEIRTFI---LSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDaGPVIVHCSAGVERTGTYIVIDAMLeqakkSRTVDIRNYLI
.... |.| |    .  . .  |.. |.... ||| |||.... .|.| . .... ... |||.||||||| ||||..... |.      . ... . | 
lkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk.....klglsleeala

ALRKDRPHMVQTKEQYSFIHS
 .|. ||..|.. .|. |.. 
lvrsrrpgavpnpgqlrfLle

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 394-576 1.9e-21 71.2 In-house 5-197 (199) alignment
Range on Protein: 394-576
Range on HMM: 5-197/199.0
RSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK---IETYGGVTVTLHQSEIFADYEIRTFILSKAKR--SGSRMVRQFHFTV
| .||.| ||  ..  ||.||||  |  |||. .     ..    |||        || ..|| .     .|| | ..||..       .| . .. || 
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDKGVPQYAT---AVLAFRRKVRALNPRDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRT--VDIRNYLIALRKDRPHMVQTKEQYSFIH
| .|  |. |     |.| |   .  .     ||||||| |   || .. .|  .   ..|.|  ||. .    ||. |  .. . ..| ||.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 394-576 2e-21 71.1 In-house 4-196 (198) alignment
Range on Protein: 394-576
Range on HMM: 4-196/198.0
RSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK---IETYGGVTVTLHQSEIFADYEIRTFILSKAKR--SGSRMVRQFHFTV
| .||.| ||  ..  ||.||||  |  |||. .     ..    |||        || ..|| .     .|| | ..||..       .| . .. || 
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDKGVPQYAT---AVLAFRRKVRALNPRDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKSRT--VDIRNYLIALRKDRPHMVQTKEQYSFIH
| .|  |. |     |.| |   .  .     ||||||| |   || .. .|  .   ..|.|  ||. .    ||. |  .. . ..| ||.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 352-455 3.1e-21 70.5 In-house 49-163 (350) alignment
Range on Protein: 352-455
Range on HMM: 49-163/350.0
NKNRYANIVAYDHSRVVLER--------VNGDEDSDYINASFIHGY----DGTPRS-FIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHK
 |||| ||. |.|||| |..            . .|||||....      .  |   .|| |.||| ... |.... . . . |..||..|||.  ||..
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPDKieTYGGVTVTLH
||..   .| ..|| | 
YWqeg..sydditvkla

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 773-872 9.1e-21 68.7 In-house 91-190 (440) alignment
Range on Protein: 773-872
Range on HMM: 91-190/440.0
VCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQII
. . |. .|||| .|..|  || .... . ||...||.|.||.|| |.||.|   |. |.|   |  . ||.| .|. .| | |  |..| || | .. .
lkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvheav





subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 348-580 1.4e-20 67.9 In-house 49-282 (302) alignment
Range on Protein: 348-580
Range on HMM: 49-282/302.0
PANKNKNRYANIVAYDHSRVVLERvngdEDSDYINASFIHGYDGTpRSFIASQGPLPP---AFEGFWRMVWEQNSQSIVMLTNLVELGKtKCHKYWP---
 .| .||.  .. ..|. .| ||     |  .|.||| ..  . | || | .| |      . | |||||.... .|.|.|    || |   ....|   
kknlkknqsedvpildsnlvklea....epdsyvnaskvevPelt.rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkks

DKIETYGGVTVTLHQSEIFADYEiRTFIL--SKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVERTGTYIVIDAM
.. ..|| . |   . |   . .   ...       | | ..   ..| |..| ||.  ... .   || |..     ....    |. | |. ..  . 
gdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlava

LEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVL
.|. .|.  . | . ....|..||..|.. .|| ... |.|
veklqkgkepnikeivksiRsqRpravdslkQyvslyiall

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 641-876 8.2e-20 65.4 In-house 50-285 (302) alignment
Range on Protein: 641-876
Range on HMM: 50-285/302.0
QNLHKNRFSDIIALNSCRVMLHNEhadeESDYINAVFLHAHRGRNAFIATQHPLLETV---EDFWRMVTDYDIGTIVMLNNLHELDQEYPQYWP-DHGA-
.||.||.  |. .|.| .| |..|    . .|.||  ..    ..  | .| | ....   |.||||| .  | ..|.|    ||..   ...|   |. 
knlkknqsedvpildsnlvkleae....pdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgdy

TKYGHIGVSVLSKQEK-GDVICTKLKVTRKKVRRKTQEVCHLHHvSWPDKCIPELACSVLDLLDEAqTSQQQCGNAPVLVQCSNGVGRSGTFCAISSVLE
..||.. | .   ... ...    . |  . .         ...  |..| .|.   ..     .    ... .......   ||.|| |.| .   ..|
keygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvlt.nWkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGRagafltlavave

RLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYF
.|....   . ...| || . | ||.| .|| . | ..  |.
klqkgkepnikeivksiRsqRpravdslkQyvslyialllyi

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 353-603 1.2e-19 65.5 In-house 22-280 (290) alignment
Range on Protein: 353-603
Range on HMM: 22-280/290.0
KNRYANIVAyDHSRVVLERVNGDEDSDYINASFIHGYDGTprSFIASQGPLPPA-------FEGFWRMVWEQNSQSIVMLTNLVELGKT----KCHKYWP
..|... ..  ..||||.       .||| |...   .|    .|..| |.           | || |. . .....||| .  |  .      | || |
dqRlevpLv.eatrvvLkgygkrfnddyiHAnrvtcpngl..rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvp

DKIE---TYGGVTVTLHQSEIFADYEIRTFILSKAKRSgSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRalnpRDAGPVIVHCSAGVERTGTYIVIDA
....   ...|.||   . |   | |.|. ..   ..     |    .  | .  |..    .|.  .||.        ||||||  |. |  .   |. 
esvgeelkfkgltvkCkskekeddvetRelvvkfddee.eftvtHsllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGiSrsAalaaiil

MLEQ-AKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAV-LEALTCGNTEIQSETYNQAMQKLA
     |..|  | ... | |||| | ..........|.  .. | |   ... ...|| ..|...  
gyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllaievldqfaeeetekkakaeek

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 694-876 1.3e-19 65.3 In-house 39-221 (255) alignment
Range on Protein: 694-876
Range on HMM: 39-221/255.0
LleTVEDFWRMVTDYDIGTIVMLNNLHELD-QEYPQYWPDHGATKYGHIGVSVLSKQEKGDVICTKLKVTRKKV-RRKTQEVCHLHHVSWPDKCIPELAC
|  ||. |....   .  ..||| ...| . ..  .|.|     |     |.| . .   ||.   |..| .   ..||..| | ..  |..|  |||| 
l..tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelar

SVLDLLDEAQTSQqqcgnaPVLVQCSNGVGRSGTFCAISSVLE----RLKTEQV--IDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYF
 .| .|  .. |.      .|.|.||.|.||| .|  . .|       |.| .   .|  .... .| . ..|.. | |  |.  .. ...
eilnilkvvrdsk......svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv

0048076 (Phosphotyrosine protein) phosphatases II 763-876 1.8e-19 65.3 In-house 37-143 (145) alignment
Range on Protein: 763-876
Range on HMM: 37-143/145.0
RKKVRRKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQQcgNAPVLVQCSNGVGRSGTFCAISSVLErlktEQvIDVFQVIKRIRVNLPGAVESP
    .  ...........||| ..|.|.  .|..|.  .. ...  . |||| || ||||.||..|.  .|.    .. ..........|   ||||..|
tselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqrpgavpnp

TQYLFCYQIIQKYF
 |. |.|. .....
gqlrflyefelell

subfamily_CG42327_pd Subfamily CG42327 643-803 3.6e-19 63.6 In-house 29-193 (319) alignment
Range on Protein: 643-803
Range on HMM: 29-193/319.0
LHKNRFSDIIALNSCRVMLHNEHADEESDYINAVFLHAHR-GRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELD-QEYPQYWPDH----GAT
  |.|. ... |   ||.|..   |... |..| ..  ..  .| .||.| .| ..  ||||.| .    .|| | .|.||  .  ..|.| .    .  
kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnts

KYGHIGVSvLSKQEKGDVICTKLKVTRKKVRRKTQEVCHLHHvSWPDKCIPELACSVLDLLDEAQTS
 ||.| |. | ..| .|   .   . ..  . ...|. |  .  |..  .|    ... .| |...|
lyGdilvt.lkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss

0048179 (Phosphotyrosine protein) phosphatases II 751-870 4e-19 64.2 In-house 48-139 (144) alignment
Range on Protein: 751-870
Range on HMM: 48-139/144.0
KgdvictklkvtrkkvrrktqeVCHLHHVSWPDKCIPELACSVLDLLDEAQTSQQqcGNAPVLVQCSNGVGRSGTFCAISsvleRLKTEQvIDVFQVIKR
                      .....|..||| ..|.|.  .|..|.  .. ..   . |||| || ||||.||..|.     ..|... .........
e.....................giqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaay....lmkklg.lsleealal

IRVNLPGAVESPTQYLFCYQ
.|   ||||..| |. |...
vrsrrpgavpnpgqlrfLle

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 406-589 3.1e-18 60.8 In-house 40-226 (255) alignment
Range on Protein: 406-589
Range on HMM: 40-226/255.0
AFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP---DKIETYGGVTVTLHQseIFADYEIRTFILS-K-AKRSGSRMVRQFHFTVWPDKGVPQYATA
. . |....  .... .|||... | |. ||..|.|   |.   .  |.||  .    ||  .||  .  . ...   . |. .... |..|  |. |  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

VLAFRRKVRalnprDAGPVIVHCSAGVERTGTYIVIDAM----LEQAKKSRTVDI--RNYLIALRKDRPHMVQTKEQYSFIHSAVLEALtCGNTE
.|   . ||     |. .|.||||.|. |. ...... .    . . ... ||..  .. |  ||. |.  ..|  | .|    ||. .   ..|
ilnilkvvr.....dsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv.fpkge

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 692-874 3.1e-18 60.3 In-house 98-286 (302) alignment
Range on Protein: 692-874
Range on HMM: 98-286/302.0
HPLLETVEDFWRMVTDYDIGTIVMLNNLHELD-QEYPQYWPDH--GATKYGHIGVSVLSKQE-------KGDVICTKLKVTRKKVRRKT-QEVCHLHHVS
 |  .|.| .| .. .|... .| | .. | . . . .|. |.  |  |.|.  |  .| ..       | ..   ..... .|...|. . |  |.. .
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPDKCIPELACSVLDLLDEAQTSQQQcgnapVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQK
|||.  |. | . ||.|   .. ...     ||| ||.||||.||. ||   ..  ....| |. .... .|    ||| . .| ..   .. |
wpdhGapkeaytaldilkfcesykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtk

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 626-747 6.7e-18 59.5 In-house 31-164 (350) alignment
Range on Protein: 626-747
Range on HMM: 31-164/350.0
SREIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLH--------NEHADEESDYINAVFLHAH----RGRNAF--IATQHPLLETVEDFWRMVTDYDIG
. | | ..  . |  .   |||...|.  .  || |.         .|. . .||||| .|.      .    |  |||| || .||.||.....  .. 
dsespsnDvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvk

TIVMLNNLHELDQE-YPQYWPDHGatkYGHIGVSVLS
 |..|... ||. | . .||.. .   |  | | . |
vilsltsdvelnlekcyrYWqegs...ydditvklas

subfamily_hpo-7_pd Subfamily hpo-7 689-874 1.9e-17 58.0 In-house 42-225 (263) alignment
Range on Protein: 689-874
Range on HMM: 42-225/263.0
AtqhpLLETVEDFWRMVTDYDIGTIVMLNNLHELD-QEYPQYWPDHGATKYGHIGVSVLSKQEKGDVICTKLKVTRK--KvRRKTQEVCHLHHVSWPDKC
     |..|.. |....      ..||| . .| . ..  .|.|     |     |.| . . . ||.   |...    . ..||..| |  .. |..| 
l....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlge.KkkthtvkhysykgWiekn

IPELACSVLDLLDEAQTSQqqcgnaPVLVQCSNGVGRSGTFCAISSVLE----RLKTEQV--IDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQK
 |||| ..| .|. |. |.      .. | ||.|.|||  |  . .|       |.| .   .|  .... .| . ..|.. | |  |   .. .
dpelareilnilkvarnsk......slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLd

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 305-390 3.9e-17 56.7 In-house 4-87 (440) alignment
Range on Protein: 305-390
Range on HMM: 4-87/440.0
KPIPIALFPEYVAKMQANggIRLENEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYD
.|| .| | .|| . .       |.|.  . .| . | . |  | || |||| ||.|||||||.|| |.|  ||||||||.| | .
rpiivadfadyvqnnrrs..rafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingie

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 406-583 5.3e-17 56.2 In-house 103-288 (302) alignment
Range on Protein: 406-583
Range on HMM: 103-288/302.0
AFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKIE---TYGGVTVT---LH-QSEIFADYEI---RT--FILSKAKRSGSRMVRQFHFTVWPDKG
. | .| .. . |   .| |...|| .. || .|. ||..   ..|  ||.   .. . | |.| .     |  .  .| |.   . |  ..|. |||.|
tlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdhG

VPQYATAVLAFRRKVRALNPRdagpVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
 |. | . |   .   .        |.||||||| |||| . |   ..  .| .. |. . .. .|. |   ||...|  ..   |  .|
apkeaytaldilkfcesykkn....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkgl

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 640-874 7.1e-17 55.9 In-house 45-277 (303) alignment
Range on Protein: 640-874
Range on HMM: 45-277/303.0
PQNLHKNRFSDIIALNSCRVMLHnehadeESDYINAVFLHAHRGRNAfIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQE-----YPQYwPDHG
 .|..|||| |.| |.  .| |       .| || | .|. .  ..| | || ||  |  |||.|. .  .  ...|    | |.      .|.   |  
vknmdknrfvdvicldhskvkls......dssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprn.qdfl

ATKYGHIGVSVLSKQEKGDVIctKLKVTRKKvRRKTQEVCHLHHV-SWPDKCIPEL-ACSVLDLLDEAQTSQ-QQCGNAPVLVQCSNGVGRSGTFCAISS
  .   | |  . . | ||    .|||       . .   |.||  .|| . ||   .  ..  . . |.   . . . | .     |.||.|||. . .
kfeersirvgefkrvelgdgw..vlkvlsvs.ngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfet

VLERLKTEQV-IDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQK
    |..||  .|. .... .|     ||.  .|. . | .. .
ahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllae

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 655-872 1.5e-16 55.4 In-house 31-255 (290) alignment
Range on Protein: 655-872
Range on HMM: 31-255/290.0
NSCRVMLHNEHADEESDYINAVFLHAHRGRnAFIATQHPLLET-------VEDFWRMVTDYDIGTIVMLNNLHELDQEYP-----QYWPDHGA--TKYGH
.  ||.|..      .||| | ..    |  ..|.|| |. ..       .|.|| |. .  .  .||| . .| ...       .| |..     |.. 
eatrvvLkgygkrfnddyiHAnrvtcpngl.rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkg

IGVSVLSKQEKGDVICTKLKVTRKKVrrKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQtsqqqCGNAPVLVQCSNGVGRSGTFCAISSVLERLK-TE
. |.  || .. ||.  .| |.  .   .   | |   ..| .  ..|   ..|.|..  .     . ..||.| | .|. || .. ||      .  |.
ltvkCkskekeddvetRelvvkfdde..eeftvtHsllkgWnklnvqedtktllsliqkvk.....asktpvivHcvdGiSrsAalaaiilgyQkiaets

QVIDVFQVIKRIRVNLPGAVESPTQYLFCYQII
. . . .|.| .| .   |. |.... |    |
gsvkledvlkalrkqralaitsalelafvdagi

subfamily_CG42327_pd Subfamily CG42327 514-578 2.2e-16 54.4 In-house 245-310 (319) alignment
Range on Protein: 514-578
Range on HMM: 245-310/319.0
RDAGPVIVHCSAGVERTGTYIVIDAMLEQAKKS-RTVDIRNYLIALRKDRPHMVQTKEQYSFIHSA
 . ||..|||| || |||. |  |  ... ..| |.||| . .  .|.|| . |.||||| ||.  
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv

subfamily_eak_pd Subfamily eak 349-508 3.5e-16 53.5 In-house 51-207 (332) alignment
Range on Protein: 349-508
Range on HMM: 51-207/332.0
ANKNKNrYANIVAYDHSRVVLERVNGDEDsDYINASFIHgYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKI---E
 . |.|   .|| ||.  | |     ...  ||||| .  .    | .| .  .       ||.|| ||.| .||.| . |||.  |  ||.|||     
eavnrn.vvkivpydrylvrltssqlnrl.Gyinaslae.fsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreel

TYGGVTVTLHQSEIFADYEIRTFILSKAKRsgSRMVRQFHFTVWPDKGVPQYAtAVLAFRRKV
 .| . |.  .    . .| | ..|||     .  |  ...  | .  .|.|    ||.|. .
kfGildverkefvkrniletrllelskGne..thrvlhykvfGwtettlpkye.dflalrkvm

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 507-583 3.6e-16 53.9 In-house 220-295 (297) alignment
Range on Protein: 507-583
Range on HMM: 220-295/297.0
KVRALNPRDAgPVIVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
 .||  ||.| ...||||||| |.|  .  |..|.. .| |  |..  |  ||. |. .||| ||. ....|||. |
slraemprna.yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 520-586 4.2e-16 53.1 In-house 2-68 (69) alignment
Range on Protein: 520-586
Range on HMM: 2-68/69.0
IVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCG
.||||.|  ||||.| |   . . |  . ||| | .  .|| || ||  . .| ||| |. |||  |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 305-401 5.1e-16 52.6 In-house 3-95 (95) alignment
Range on Protein: 305-401
Range on HMM: 3-95/95.0
KPIPIALFPEYVAKMQANGGIRLENEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLErvnGDEDSDYINASFIHGYDGTpRSFIASQG
||| ...|  .| .|..|    ..||.|  .     |. .    ||  |||. ||. || .||||       ||||||| |. ||      .||.||
kpihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlt...tkrdsdyinacfvdgyark.ncyiaaqg

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 520-586 7e-16 52.3 In-house 1-67 (69) alignment
Range on Protein: 520-586
Range on HMM: 1-67/69.0
IVHCSAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCG
.||||.|  ||||.| |   . . |  . ||| | .  .|| || ||  ...| ||| |. |||  |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 350-582 7.9e-16 52.5 In-house 47-278 (303) alignment
Range on Protein: 350-582
Range on HMM: 47-278/303.0
NKNKNRYANIVAYDHSRVVLervngdEDSDYINASFIHgYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKIE----
| .|||.....  |||.| |       || || ||...  | . .  | .| ||. .   ||.|. ||. . ...|    |  |   .  .| . .    
nmdknrfvdvicldhskvkl......sdssyihasyle.ld.sskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

-TYGGVTVTLHQSEIFADYEIRTFILSKAkrSGSRMVRQFHFTVWPDKGVPQY-----ATAVLAFRRKVRALnpRDAGPVIVHCSAGVERTGTYIVID-A
         ... |.   . ..   .|.   .   ..   |.  || . .|          .   .  .|     |. | .    .|. |.||. ... |
eersirvgefkrvelgdgwvlkvlsvsng..dyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrky..sdstptvymslsgcgragtfalfeta

MLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
 |   ..  ..|. . |  .|. | | ||   |.|.... . | 
hlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaeh

subfamily_hpo-7_pd Subfamily hpo-7 406-618 1e-15 52.3 In-house 46-260 (263) alignment
Range on Protein: 406-618
Range on HMM: 46-260/263.0
AFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP---DKIETYGGVTVTLHQSEIfaDYEIRTFILSK--AKRSGSRMVRQFHFTVWPDKGVPQYATA
. . |....  .... .|||..  | |. || .|.|   |.   .  |.|.  ..    |  ..|  | .   ..   . |... .. |..|  |. |  
tidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpelare

VLAFRRKVRalnprDAGPVIVHCSAGVERTGTYIVIDA----MLEQAKKSRTVDI--RNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSET
.|   . .|     .  ...||||.|. |.  . |..     |. . ... ||..  .. |  ||. |.  ..|  | .|    ||. .   ... . |.
ilnilkvar.....nskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfakgelea

YNQAMQKlaSVNRKFQMTGYALEF
  | ..|  |  .  ||    |||
kyqeirk..sylharqmmhkdlef

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 646-881 1.3e-15 51.9 In-house 47-281 (312) alignment
Range on Protein: 646-881
Range on HMM: 47-281/312.0
NRFSDIIALNSCRVMLhnehADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQEY-PQYWPDHG-AT------K
||. .|   .  |  |    | .|  || | |..     . |..|| || .|.  ||...      .|..|  . |   |   .|  |            
nrypniqcwdrgrftl....agdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrv

YGHIGVSV-LSKQEKGDVICTKLKVTRKKVRrKTQEVCHLHHVSWPDKCIPELACSVLDLLDEAQTSqqqcgNAPVLVQCSNGVGRSGTFCAISSVLERL
|      . .  . |  .    |||  |    .   . |    ||||. .|.   . | ||   .       . ||. .|| ||||.||.. | |..  |
yteycteieiggkskdkithrvlkvvvkatg.qesklnhyqwaswpdhgmpdscdtalrllsavkkd.....kkpviahcsagvgrtgtlaliesmiaal

KTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYFDSFSD
.  .  .| ..   .| .   .|.   ||... ... ... | . 
rhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskgl

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 683-733 9.3e-14 45.6 In-house 234-282 (440) alignment
Range on Protein: 683-733
Range on HMM: 234-282/440.0
GRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHelDQEYPQYWPDH
 .||||||| ||  || ||||.| || | ||.|||.|   |.    |||  
kknafiatqmpldstvldfwrlvhdyristiimlnqln..dktcsiywpvn

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 578-745 8.6e-13 42.5 In-house 34-195 (244) alignment
Range on Protein: 578-745
Range on HMM: 34-195/244.0
AVLEALTCGNTEIQSETYNQAMQKLASVNRKFQMTGYALEFQRLNSVtSREIPAEEKSVgEEPQNLHKNRFSDIIALNSCRVMLHNEHAdeESDYINAVF
||| | .. |  |.   ....   |.| ...      |   |  ...  |  |.  | .  .|.| .||| .  . ..  || | .        |||| |
avlsanatknryinilpfdetrvilssskkegsdyinanyiqgsqni.irpdpsvmkda.fnpnnswknregaglpfdfnrvplskgsm..gntyinasf

LHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDQeypqYWPDHGATKYG--HIGVSV
.        .| ||||| .|  |||.|. .  .  .|.|  . | |.    ||||    ..    | |..
vgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede....ywpdseplewyeeditvtl

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 352-458 9.5e-13 42.2 In-house 50-169 (349) alignment
Range on Protein: 352-458
Range on HMM: 50-169/349.0
NKNRYANIVAYDHSRVVLERVN--------------GDEDSDYINASFIHGYDGTP-RSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKC
 |||| .|. |.||||.|..                .    ||||| ...    .. . .|| | ||| . . |....  .. . .. |..  ||.  ||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

HKYWPDKieTYGGVTVTLHQSE
..|| .   .| ..|| |  | 
diywqel..sysnitvklqnss

fn3 Fibronectin type III domain 1-82 1.5e-12 40.7 Pfam-A 3-85 (85) alignment
Range on Protein: 1-82
Range on HMM: 3-85/85.0
PSSLNSKAMTSTSIRVTWSTLPetCTNGIVRKYVISYHKDGGSN-ETTEVIGAPT-SFDINNLAKYTKYTIKVRGYTLK-EGPWS
|. |. ...||||....||  .    .| . .| . | ..||.. ...  . ..| |. ...|  .|.|...|. .. . |||.|
PenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 514-580 3e-12 40.9 In-house 260-341 (350) alignment
Range on Protein: 514-580
Range on HMM: 260-341/350.0
RDAGPVIVHCSAGVERTGTYIVIDAMLE-------QAKKSRTVDIRN--------YLIALRKDRPHMVQTKEQYSFIHSAVL
  . |..||||||| ||||.. .| .|.         |.|| .|  .         .  ||| |  |||...|. ||. |.|
arsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeall

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 329-444 2.1e-11 37.0 In-house 6-88 (169) alignment
Range on Protein: 329-444
Range on HMM: 6-88/169.0
NEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINAsfihgydgtprsfiasqgplppafegfwRMVWEQNSQSIVMLTNL
|| |.| .  ..    |   .|. ||| |  .|  | || |.||  |  ||||||                            ||.|| |.  ||.| . 
nelkefmktieynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlgdt

VElgktkCHKYWPDKI
 .        .||.| 
dd.....knnfwpeke

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 329-444 2.5e-11 36.7 In-house 5-87 (169) alignment
Range on Protein: 329-444
Range on HMM: 5-87/169.0
NEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINAsfihgydgtprsfiasqgplppafegfwRMVWEQNSQSIVMLTNL
|| |.| .  ..    |   .|. ||| |  .|  | || |.||  |  ||||||                            ||.|| |.  ||.| . 
nelkefmktieynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlGdt

VElgktkCHKYWPDKI
 .        .||.| 
dd.....knnfwpeke

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 345-493 3e-11 37.4 In-house 91-234 (244) alignment
Range on Protein: 345-493
Range on HMM: 91-234/244.0
ARKPANKNKNRYANIVAYDHSRVVLERvnGDEDSDYINASFIhGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVElgktkCHKYWPDK-
| .| |  ||| .  . .| .|| | .  |     ||||||. |  |    .| .| ||  .   ||.|. |.  . .|.|  . |       .||||  
afnpnnswknregaglpfdfnrvplsk..gsmgntyinasfv.gclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsvee.....edeywpdse

-IETYG-GVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKG
 .| |   .|||| . . | .     . .        . .  |  . ||  |
plewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdg

subfamily_CG42327_pd Subfamily CG42327 803-876 3.7e-11 37.3 In-house 241-315 (319) alignment
Range on Protein: 803-876
Range on HMM: 241-315/319.0
SQQQCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTE-QVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYF
| ..  . |. | ||.||||.|.  |    ...|..  . .|. |..  .| .   || .  || | |.....| 
sgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 684-876 5.8e-11 35.6 In-house 114-309 (346) alignment
Range on Protein: 684-876
Range on HMM: 114-309/346.0
RNAFIATQHPLLE---TVEDFWRMVTDYDIGTIVMLNNLHELDQEYPQYWPDHGaTKYGHIGVSVLsKQEKGDVICTKLKVTRKKVRRK--TQEVCHLH-
 . .| .| | .|    ||||| |. . .|  . ..     | .     . |     | . |  .. .. . ||     . | . .        .|..| 
ehklivaqlpqmenesfvedfwymiyqeqihlvylmvpddklkntttslfnden.ggyqytgkmfi.nnrradvsgdpkeytievlpegnsdsvicqvhh

HVSWPDKCIPELACSVLDLLDEAqTSQQQCGNAPVLVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQIIQKYF
|  |     |  .  .. .. .   |..|  || | |    | ||. .|      ...|      ......| |. . ||.||| .||   | |.  | 
hapwkhlqqppktlpiikmihqf.lsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyi

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 638-715 6.2e-11 36.4 In-house 33-115 (347) alignment
Range on Protein: 638-715
Range on HMM: 33-115/347.0
EEPQNLHKNRFSDIIALNSCRVMLHNE-----HADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVM
|  ..| |||  |    .. ||.|  |     .||.   ||||  ..    .. .| ||.|| .|| |||.||.   .  .| 
ewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt

subfamily_eak_pd Subfamily eak 620-788 1.4e-10 35.1 In-house 28-196 (332) alignment
Range on Protein: 620-788
Range on HMM: 28-196/332.0
RLNSVT--SREIPAEEKSVGEEPQNLHKNrFSDIIALNSCRVMLHNEHADeESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLN
|.| |.   .  ..  .|...  .....|   .|.  .   | | .   . .  ||||  .      . .| |  .  . |  ||.|| .    .||.| 
rinivadlddyqrllsisetarleavnrn.vvkivpydrylvrltssqln.rlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqll

NLHELD-QEYPQYWPDHG--ATKYGHIGVSVLSKQEKGDVICTKLKVtrkKVRRKTQEVCHLHHVSWPDKCIPE
.  ||. ... .|.||..    |.|.. |   .  ... .   .|..   ..  .| .| | .   | .  .| 
edvelkleksdkyfpdktreelkfGildverkefvkrniletrllel...skGnethrvlhykvfGwtettlpk

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 669-783 2.7e-10 34.6 In-house 12-123 (130) alignment
Range on Protein: 669-783
Range on HMM: 12-123/130.0
ESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNNLHELDqeypQYWPDHGATK-Y-GHIGVSVLSKQEKGDVICTKLKVtRKKV
. .|||| |.      . .. ||||| .|  |||.|. .  .  .|.|  . | |    .||||    . |  .| |..  ..|   .  ..|..  ...
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed....eywpdsePlewyeediivtltdrdefknikasnlei.esdl

RRKTQEVCHLHHVSWPD
 .  | .  ..   || 
neshqaltmfqisnwps

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 813-870 6e-10 33.4 In-house 2-59 (69) alignment
Range on Protein: 813-870
Range on HMM: 2-59/69.0
LVQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQ
.|.|| | ||.||| ||   . |.|.|...|.|  .. .|   |  |    .|.| . 
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihd

subfamily_eak_pd Subfamily eak 517-591 8.9e-10 32.5 In-house 238-313 (332) alignment
Range on Protein: 517-591
Range on HMM: 238-313/332.0
GPvIVHCSAGVERTGTYIVIDAMLE--QAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQ
 | |. .. |  |.|...||| ...  ..||  .  . ....  .. | | | .. |.|||. .||. |   | ...
ap.iiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnrlr

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 814-870 1.1e-09 32.5 In-house 2-58 (69) alignment
Range on Protein: 814-870
Range on HMM: 2-58/69.0
VQCSNGVGRSGTFCAISSVLERLKTEQVIDVFQVIKRIRVNLPGAVESPTQYLFCYQ
|.|| | ||.||| ||   . |.|.|...|.|  .. .|   |  |    .|.| ..
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihd

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 631-733 4.2e-09 30.2 In-house 37-156 (349) alignment
Range on Protein: 631-733
Range on HMM: 37-156/349.0
AEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHN--------EHADEE------SDYINAVFLHAHRG--RNAFIATQHPLLETVEDFWRMVTDYDIGTIV
...  . |  .   |||..||.  .  ||.|..        ...  |       ||||| .|.  |    . .|||| ||  ||.||.....   .  ..
iddvilseGvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvl

MLNNLHELDQEY-PQYWPDH
 ||. .||. |   .|| . 
sLnddkelslekcdiywqel

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 773-876 7.5e-09 29.8 In-house 217-344 (350) alignment
Range on Protein: 773-876
Range on HMM: 217-344/350.0
VCHLHHVSWPDK---CIPELACSVLD----LLDE--AQTSQQQCGNAPVLVQCSNGVGRSGTFCAISSVLE---RLK---T--------EQVID-VFQVI
| .|.   |.|      ||   ..|.    |.|.  |..  ..   .|.|| || |||| ||.... |.|.    |.             .. | .....
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

KRIRVNLPGAVESPTQYLFCYQIIQKYF
...|      | . .|..|.|. .. ||
nelrkqrismvqnldqfifiYeallfyf

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 350-423 8.2e-09 29.4 In-house 37-114 (347) alignment
Range on Protein: 350-423
Range on HMM: 37-114/347.0
NKNKNRYANIVAYDHSRVVLER-----VNGDEDSDYINASFIHgYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIV
. .|||  .    | .||||        . |.   ||||| |. .| . . .| .| ||| .   ||.||   .   .|
slsknrskdvklidatrvvlspeksknsraddvetyinashik.fdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvv

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 349-433 1.7e-08 28.3 In-house 33-115 (332) alignment
Range on Protein: 349-433
Range on HMM: 33-115/332.0
ANKNKNRYANIVAYDHSRVVLERVNGDedSDYINASFIHGYDGTpRSFIASQGPLPPAFEG-FWRMVWEQNSQSIVMLTNLVELGK
 | . ||   . ..||||| |   .|    |. |||.. ||     ..| .| |.    |  ||||| |..   |... .. |  |
nnmdmnriphlycfdhsrvelapqdgk..ddfynaswvdgyskk.sayifaqapfndhteyvfwrmvserkpsmilvfgdidekqk

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 430-576 1.9e-08 28.1 In-house 144-295 (332) alignment
Range on Protein: 430-576
Range on HMM: 144-295/332.0
ELGKTKCHKYWPDKIETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDK-GVPQYATAVLAFRR--KVRALN--PRDAGPVIVHCS
||    |.|.||.|       ..... |. ...  ..|| |. ...   .    .||  | |   .|.|   . |  .   .|. .      ||... |.
elkakicrkfwpekrskkdfpalsiqasddhsethmktfnltvtekkqdhqtvlmhfyewadasklpeymldmrasiklqyirsskktgvcigpimlvca

AGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIH
.|||.   .  || .. .  . . | ... . |.. .|   ..|   ||   
tgvekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpystac

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 634-691 7.3e-08 26.5 In-house 40-94 (95) alignment
Range on Protein: 634-691
Range on HMM: 40-94/95.0
KSVGEEPQNLHKNRFSDIIALNSCRVMLHNEhadEESDYINAVFLHAHRGRNAFIATQ
 .||    |. |||| .|.  .. ||.|       .||||||.|.  .  .|..||.|
ytvgsseanipknrflnifpydatrvvlttk...rdsdyinacfvdgyarkncyiaaq

fn3 Fibronectin type III domain 97-170 1.1e-07 25.1 Pfam-A 2-85 (85) alignment
Range on Protein: 97-170
Range on HMM: 2-85/85.0
PPLGVNHTEIYSTTFNISWDPIPkdQSNGIITSYDLELI------------LNSTLTYIVLHNLENCTIYHLRVRARTGKGPGPYS
.| ... .|. ||....||.| .  . .| ||.|..|.             . .| |  .|..|.  | |..||.|..|.| ||.|
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 515-581 1.1e-07 25.5 In-house 264-342 (349) alignment
Range on Protein: 515-581
Range on HMM: 264-342/349.0
DAGPVIVHCSAGVERTGTYIVIDAMLE----QAKKSRTVDIRNY-------LI-ALRKDRPHMVQTKEQYSFIHSAVLE
.  ...||||||  |||... .| .|.      ..|  .....         .  ||| |  |||   |. .|. |.|.
qlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLk

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 340-390 2.3e-07 24.7 In-house 29-78 (244) alignment
Range on Protein: 340-390
Range on HMM: 29-78/244.0
FPWEAARKPANKNKNRYANIVAYDHSRVVLERVnGDEDSDYINASFIHGYD
|    |   ||  |||| ||. .|..||.|      | ||||||..|.| .
flqtnavlsanatknryinilpfdetrvilsss.kkegsdyinanyiqgsq

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 394-470 3e-07 24.1 In-house 236-311 (440) alignment
Range on Protein: 394-470
Range on HMM: 236-311/440.0
RSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVElgkTKCHKYWPDK--IETYGGVTVTLHQSEIFADYEIRTFIL
 .|||.| ||  .   |||.| . .  .|.|| .| .     |  ||| .    |.|  ||  . || .    .||. |
nafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlel

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 362-493 3.4e-07 24.6 In-house 5-125 (130) alignment
Range on Protein: 362-493
Range on HMM: 5-125/130.0
YDHSRVVlervngdeDSDYINASFIhGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVElgktkCHKYWPDK--IETY-GGVTVTLHQSE
.. ||.         . .||||||. |  |  . .. .| ||  .   ||.|. |.    .|.|  . |       .||||   .| |   ..||| . .
fevsrlq........gntyinasfv.Gllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsvee.....edeywpdsePlewyeediivtltdrd

IFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKG
 |   .   .  ..      . .  |. . ||  |
efknikasnleiesdlneshqaltmfqisnwpsdg

subfamily_PTPDC1_pd Subfamily PTPDC1 487-576 2.1e-06 22.3 In-house 88-169 (182) alignment
Range on Protein: 487-576
Range on HMM: 88-169/182.0
TVWPDKGVPQYATAvLAFRrKVRALNPrDAGPVIVHCSAGVERTGTyiVIDAMLEQAKKsrtVDIRNYLIALRKDRPHMVQTKEQYSFIH
  |.| ||.   .. |    || |    . | | ||| ||  |||   .| ..|  ||.   ..  . .  .|. ||. .||.||  ...
fgwkDygvasleri.Ldiv.kvvafal.qegkvavhChaGlGrtGv..liacylvyakr...ltaekaiklvrskrpksiqtreqvelvk

0038934 (Phosphotyrosine protein) phosphatases II 485-576 2.6e-06 22.7 In-house 83-170 (194) alignment
Range on Protein: 485-576
Range on HMM: 83-170/194.0
HFTVWPDKG-VPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVERTGTYIVIDAMLeqakkSRTVDIRNYLIALRKDRPHMVQTKEQYSFIH
.   .||.| ||....    ..   . ||    | | ||| ||. |||| ..   .      ..  . .  .  .|  ||..... .... ..
lklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiy.....rlgmsaeeAialfrekRpgaipnqdyleall

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 800-838 9.9e-06 19.1 In-house 256-294 (349) alignment
Range on Protein: 800-838
Range on HMM: 256-294/349.0
AQTSQQQCGNAPVLVQCSNGVGRSGTFCAISSVLERLKT
|.   ..   ...|| || | ||.|... . ..|. |. 
arlyldtdqlstllvhcsaGcGrtGvlvtldlllsilep