Gene NvecPTP-sf2-7 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily NvecPTP-sf2
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP050_AA protein Get Run
NvecP050_AA_315-569 phosphatase_domain Get Run
NvecP050_AA_581-736 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 310-738 1.9e-214 708.5 In-house 2-450 (564) alignment 
Range on Protein: 310-738
Range on HMM: 2-450/564.0
SKPIPIALFPEYVAKMQANGGIRLETEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPL
|||||.| ..|.|||..||.....|.||||...||||.||||.|||||.|||||||||||||||||..|.|||.|||||||||.||. .....||.||||
skpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPl

PPTFEDFWRMVWEQNSQSIVMLTNLVELNKTKCHKYWPDK-IETYGGVTVTLHQSELFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVL
..|.||||||||||||..|||||.|.| .|.|||||||.|  ||||..||||...| .||||||||.|.|.|.| ||.||||||| |||.|||..||..|
aetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslL

A---------------------AGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEALTCGNTEIQSENFNQTTQKL
.                     |||.||||.||||||||..|...||||..|..||||.|..||||.||| |||.|.||||.|||||..|||..|..|||
dlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkL

ASVNRKFQMTGYALEFQRLNsvTSHEIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFW
|.|.....|||..||||||.  |..||..||..|...|.|..|||||.|.||.||||.|....|.||||||||..|.|.|...||||||.|| .||||||
aeveedtemtgleleFqrLa..takeieleefavatkpknkkknrfsnilalescrvvlsairakeesdyinasyleayrekrafiatqaplkntvedfw

RMVTDYDIGTIVMLNSLHE-LDQEYPEYWPDHGPTKYGHIGVSVLSKQEKGD
|||.......||||..|.| |..|. ||..|.. ||||.|...||.|.||.|
rmvweeevkiivmltkleekleeesseyysdleatkyGeitikvlkkkeksd
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 307-509 1.7e-89 295.0 In-house 3-209 (298) alignment 
Range on Protein: 307-509
Range on HMM: 3-209/298.0
DDLSKPIPIALFPEYVAKMQANGGIRLETEYKKFNNGQQ----FPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPrSF
....... .|......|...... .....|....|....    . .|.||||.||.|||||.|.|.|.||||||....||.||||||||.|.|.|.. .|
teieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn.af

IASQGPLPPTFEDFWRMVWEQNSQSIVMLTNLVELNKTKCHKYWPD-KIETYGGVTVTLHQSELFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVP
||.|.||..|.|||||||.|.....|||||||.||.|||.|||||| . |||| .||.|...| |||...|....||.|....|.|||.|||.|||||||
iatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvp

QYATAVLA
..||.||.
enatsvld
0050432 (Phosphotyrosine protein) phosphatases II 311-572 9.8e-88 289.7 In-house 24-303 (308) alignment 
Range on Protein: 311-572
Range on HMM: 24-303/308.0
KPIPIALFPEYVAKmqANGGIRLETEYKKFNNGQQ-FPWEAARKPANKNKNRYANIVAYDHSRVVLervngDEDSDYINASFIHGYD-GTPRSFIASQGP
.....  . ... |  |..  .||.|...... .  .....|..|.||.|||| .|..||||||.|     ||.|||||||...||. . || ||| |||
lklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgP

LPPTFEDFWRMVWEQNSQSIVMLTNLVELNKTKCHKYWPDK----IETYGGVTVTLHQSELFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYA
|| |.|||||||||||.. |||||.||| .. ||..|||..    ...||..||||   | ..|| .||..|.. . . ||.|..||.| ||| |||...
lpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpsp

TAVLA-------------------AGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEALTCGN
...|.                   ||| ||||.|..| .||| .| ..||. ...  ||. ||.||||.|||||.. |.|| | .  
eilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
0051299 (Phosphotyrosine protein) phosphatases II 311-568 2.1e-87 288.5 In-house 3-286 (288) alignment 
Range on Protein: 311-568
Range on HMM: 3-286/288.0
KPIPIALFPEYVAKMQANGGIRLETEYKKFNNGQ-QFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRsFIASQGPL
..|..  . ..| |..|||  .|. |.... . . .... ||..|.|..|||| .|..||||||.|  ..|.|.|||||||.|.||. . . ||| ||||
teisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk.fIatqgPl

PPTFEDFWRMVWEQNSQSIVMLTNLVELNKTKCHKYWP-DKIETYGGVTVTLHQSELFADYEIRTFILSKA----KRSGSRMVRQFHFTVWPDKGVPQYA
| |.|||||||||||.. |||||.||||...||..||| .. .||| .||||   | ..|| .||.....     . . ||.|..||.| ||| |||...
pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

TAVL---------------------AAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEAL
...|                      ||| ||||.|..| .||| .| ..||. ...  ||. ||.|||| |||.|.. |.||.|
ellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0040438 (Phosphotyrosine protein) phosphatases II 318-579 9.3e-86 283.3 In-house 5-287 (317) alignment 
Range on Protein: 318-579
Range on HMM: 5-287/317.0
FPEYVAKMQANGGIRLETEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRsFIASQGPLPPTFEDFW
..... .. ...  .|. |.... . .  ... |..|.||.|||| .|. ||||||.|  ..||.||||||||...|.. ... ||| ||||| |.||||
lllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrk.fIatqgPlpntvedFw

RMVWEQNSQSIVMLTNLVELNKTKCHKYWP-DKIETYGGVTVTLHQSELFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLA-------
||||||....|||||.|.||.. ||..||| ..  |||..|||| . |  |....||. ... . | ||.|..||.| ||| |||.. . .|.       
rmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavre

--------------AGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEALTCGNTEIQSEN
              ||| ||||.|... |||| .| ..||. . .  ||. ||..||| ||| |.. |.|| |....| .   .
aledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepase
0046845 (Phosphotyrosine protein) phosphatases II 333-573 1.8e-83 275.5 In-house 2-279 (284) alignment 
Range on Protein: 333-573
Range on HMM: 2-279/284.0
LETEYKKFNNGQQF---PWEAARKPANKNKNRYANIVAYDHSRVVLERVNGD-EDSDYINASFIHGYD----GTPRSFIASQGPLPPTFEDFWRMVWEQN
|| |... .. . .   ....|..|.|..|||| .|..||||||.| ...|| |||||||||...|||     ... ||| ||||| |.|||||||||||
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

SQSIVMLTNLVELNKTKCHKYWPDK--IETYGGVTVTLHQSELFADYEIRTFILSKAK-RSGSRMVRQFHFTVWPDKGVPQYATAVL-------------
.. |||||.||| ...||..|||..    |||..||||   | . || .||. |.. .  . ||.|..||.| ||| |||.... .|             
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

----------AAGVERTGTYIVIDAMLEQAKKSR---TVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEALTCGNT
           ||| ||||.|..| .||| .| .   .||. ...  ||. ||.|||| |||.|.. |.||.| ...|
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt
subfamily_PTPRG_pd Subfamily PTPRG 313-584 2e-83 275.5 In-house 1-303 (563) alignment 
Range on Protein: 313-584
Range on HMM: 1-303/563.0
IPIALFPEYVAKMQANGGIRLETEYK---KFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDS-DYINASFIHGYDgTPRSFIASQGP
.|.  | ..||.. |.| |... |..   .  . .... |...|| ||.|||| ||||||.||| |. . | ... |||||..|.||    . |||.|||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyq.kskafiatqgp

LPPTFEDFWRMVWEQNSQSIVMLTNLVELNKTKCHKYWP-DKIETYGGVTVTLHQSELFADYEIRTFILSK--AK----RSGSRMVRQFHFTVWPDKGVP
|. ||.|||||.||||.. |||.||||| .. ||. ||| |. |||| ..||| ..| .| | .||... .   |    .   ..|||.|.| |||.|||
lkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvP

QYATAVLA---------------------AGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEALTCGNTEIQSENF
.... ||                      ||| |||||||.|..|.| ..  .|.. . |  .|  |...|||.|||.|.| |.|||.. ..||...|. 
ehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqv

NQTT
..  
eelk
0043336 (Phosphotyrosine protein) phosphatases II 313-566 3.4e-82 271.3 In-house 2-275 (278) alignment 
Range on Protein: 313-566
Range on HMM: 2-275/278.0
IPIALFPEYVAKMQANGGIRLETEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRsFIASQGPLPPT
|..  ........ .|.  .|. |...... . .... |..|.||.|||| .|..||||||.|. ..||.||||||||.. ||. ... |||.||||| |
isvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprk.fiatqgPlpet

FEDFWRMVWEQNSQSIVMLTNLVELNKTKCHKYWPDKIETYGGVTVTLHQSELFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVP-------QYAT
.|||||||||.....|||||.||||...||..|||.. .|||..||||   | ..|| .||. ... . . ||.|...|.. ||| |||       ..  
vedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflk

AVLA--------------AGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLE
||.               ||| ||||.|... .|||..| ..||. . .  ||. ||..||| .|| |.. |.||
avrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
0039614 (Phosphotyrosine protein) phosphatases II 312-572 4.5e-82 271.1 In-house 13-293 (297) alignment 
Range on Protein: 312-572
Range on HMM: 13-293/297.0
PIPIALFPEYVAKMQANGGIRLETEYKKFNNGQQfPWEAARKPANKNKNRYANIVAYDHSRVVLERVNG-DEDSDYINASFIHGYDGTPRSFIASQGPLP
|||.  .. .. ...||.  .|..|...  . .  ... |..|.||.|||| .|..||||||.|  ..| |.||||||||.. ||| ..| |||.|||||
piplsvldlllllekansktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlp

PTFEDFWRMVWEQNSQSIVMLTNLVELNKtKCHKYWPDKIETYGGVTVTLHQSELFADYEIRTFILSKakRSGSRMVRQFHFTVWPDKGVPQYATAVL--
 |.||||||||||....|||||.||||.. ||..|||.. .|||..|||| . |  ..| .||. ...   . ||.|..|..| ||| |||.... .|  
etvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeeggtygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslelllef

---------------------AAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEALTCGN
                      ||| ||||.|... |||| .| ..||. . .  ||. ||..||| .|| |.. |.|| | ...
lelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
0036941 (Phosphotyrosine protein) phosphatases II 331-575 7e-81 267.1 In-house 13-284 (297) alignment 
Range on Protein: 331-575
Range on HMM: 13-284/297.0
IRLETEYKKFNNGQ-QFPWEAARKPANKNKNRYANIVAYDHSRVVLervnGDEDSDYINASFIHGYDGTPRsFIASQGPLPPTFEDFWRMVWEQNSQSIV
 .|..|.... . . ......|..|.|..|||| .|..|||.||.|    .||.|||||||.. ||| . . ||| ||||| |.|||||||||||...||
alllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrk.fIatqgPlpntvedFWrmvweqnvtvIv

MLTNLVELNKTKCHKYWP---DKIETYGGVTVTLHQSEL--FADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVL----------------
|||.||||.. ||..|||   ..  |||..||||   |   ..|| .||. ... . . ||.|..||.| ||| |||.... .|                
mltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsg

-------AAGVERTGTYIVIDAMLEQAK---KSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEALTCGNTEI
        ||| |.||.|..| ||.| .   | ..||| ...  ||. ||..||| |||.|.. |.|| | ...| .
gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltke
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 350-509 3.9e-80 263.6 In-house 3-161 (250) alignment 
Range on Protein: 350-509
Range on HMM: 3-161/250.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLPPTFEDFWRMVWEQNSQSIVMLTNLVELNKTkCHKYWP-D
 |.||.||.|||||.|.|.|.||||||...||..||||||||.||||.. ..|||.||||..|.|||||||.|..|..|||||||.| .|| .|.||| .
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve

KIETYGGVTVTLHQSELFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLA
| |.||.|||.|...| ||||..|...|||||....|.|||.||.||||||||..|||||.
kaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLe
subfamily_PTPRA_pd Subfamily PTPRA 311-602 1.3e-79 262.5 In-house 12-329 (330) alignment 
Range on Protein: 311-602
Range on HMM: 12-329/330.0
KPIPIALFPEYVAKMQANGGIRLETEYKKFNN-GQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPL
 |.|.  . | . . .|.   ..  |.. .     |   |.| |  ||.|||. ||. ||.|||.|  ..| |.|||||||||.||     .|||.|||.
fplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykek.dkfiaaqGPk

PPTFEDFWRMVWEQNSQSIVMLTNLVELNKTKCHKYWPDK-IETYGGVTVTLHQSELFADYEIRTFILS----KAKRSGSRMVRQFHFTVWPDKGVPQY-
  | ||||||.|||.|..|||||.| | ...||..||||. . ||| ..|.......  || .| |..     ....  ||.||||||| ||| |||   
eetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfep

-----------------ATAV---LAAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEALTCGNTEIQSENFNQT
                 | ..    .||| ||||.||.||.||. |  | ||. . .  ||. ||.||||.||| ||. ..||    |.||..   ... 
iGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekh

TQKLASVNRKFQMTGYALE
 ||| .   ... .|   |
lqklynkitgtdkigleee
0047943 (Phosphotyrosine protein) phosphatases II 326-568 2.6e-79 261.8 In-house 7-272 (273) alignment 
Range on Protein: 326-568
Range on HMM: 7-272/273.0
QANGGIRLETEYKKFNNGQ-QFPWEAARKPANKNKNRYANIVAYDHSRVVLervnGDEDSDYINASFIHGYDGTPRsFIASQGPLPPTFEDFWRMVWEQN
...|  .|. |.... . . ......|..|.||.|||| .|..||||||.|    ||..|||||||.. ||. ... ||| ||||| |.|||||||||||
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrk.fiatqgPlpntvedfwrmvweqn

SQSIVMLTNLVELNKTKCHKYWPDK----IETYGGVTVTLHQSELFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVL------------
.. |||||.||||.. ||..|||..     .||| .||||   | ..|| .||..|.. . . ||.|..||.| ||| |||.. . .|            
vrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalea

-----------AAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEAL
            ||| ||||.|..| .|.| .| ..||. ...  ||. ||.|||| |||.|.. |.|| |
lpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0045450 (Phosphotyrosine protein) phosphatases II 309-568 5.3e-78 258.1 In-house 5-304 (307) alignment 
Range on Protein: 309-568
Range on HMM: 5-304/307.0
LSKPIPIALFPEYVAKMQANGGIRLETEYKKFNNGQQF---PWEAARKPANKNKNRYANIVAYDHSRVVLERVNGD-EDSDYINASFI--------HGYD
||..|..  .  .|.......  .|. |..|... . |   ....|..|.||.|||| .|..|||.||.|  ..|. |||||||||..        .|||
lslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgyd

GtPRSFIASQGPLPPTFEDFWRMVWEQNSQSIVMLTNLVELNKTKCHKYWPDK--IETYGGVTVTLHQSELFADYEIRTFILSKA-KRSGSRMVRQFHFT
  .| ||| ||||| |.||||||.|||... |||||.||||.. ||..||||.    ||| .||||   |  ..| .||. ..   . . ||.|..||.|
l.krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhyt

VWPDKGVPQYATAVL-----------------------AAGVERTGTYIVIDAMLEQAKKSRT---VDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEA
 ||| |||..   .|                        ||| ||||.|... ||.| .|  |   ||... .  ||. ||..||. ||| |.. |.|| 
gwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel

L
|
l
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 571-738 1.5e-77 255.8 In-house 1-168 (298) alignment 
Range on Protein: 571-738
Range on HMM: 1-168/298.0
GNTEIQSENFNQTTQKLASVNRKFQMTGYALEFQRLNSVTShEIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRN
|||||..|......||||.|..|...|||||||||||||.| ||..|||.|...|.| .|||..|||||.|.||.|.||.||||||||||.||||..|||
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvss.eieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn

AFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHELDQ-EYPEYWPDHGPTKYGHIGVSVLSKQEKGD
||||||.|| |||||||||||..||||||||..|.|||. .|..||||.| ..||.| ||.|||.|..|
afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefad
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 313-508 6.1e-73 240.6 In-house 2-198 (318) alignment 
Range on Protein: 313-508
Range on HMM: 2-198/318.0
IPIALFPEYVAKMQANGGIRLETEYKKF-NNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPP
|..  . . |......| . |..||...  . ... .  . .|.||.|||||||.||||.|| |. ..|.|.||||||..| ||    ...||.|.||| 
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyr.rkkayiaaqaPlpe

TFEDFWRMVWEQNSQSIVMLTNLVELNKTKCHKYWPDKI-ETYGGVTVTLHQSELFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVL
|.||||||||||||. |||||...|  |.|.|.|||.|  ..|| ..|.|...  ..|| .|.| ... . . ||.|||.|.| |||.|||. .. .|
tieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgasll
0040439 (Phosphotyrosine protein) phosphatases II 347-568 1.6e-71 236.1 In-house 2-246 (249) alignment 
Range on Protein: 347-568
Range on HMM: 2-246/249.0
PWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRsFIASQGPLPPTFEDFWRMVWEQNSQSIVMLTNLVELNKTKCHKYW
... |..|.||.|||| .|..||||||.|. ..| ..|||||||.|.||. ..| ||| ||||| |.||||||.||.....|||||.||||.. ||..||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr.fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqyw

P-DKIETYGGVTVTLHQSELFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVL-----------------------AAGVERTGTYIVID
| ..  .||..|||| . | ..|| .||. |.. . . ||.|.....| ||| |||..   .|                        ||| ||||.|...
plggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaay

AMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEAL
 |||| .| ..||. ...  ||. ||..||. ||| |.. |.|| |
lmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
DSPc_SM00195 333-568 1.1e-70 233.3 In-house 2-262 (263) alignment 
Range on Protein: 333-568
Range on HMM: 2-262/263.0
LETEYKKFNNGQ-QFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYdGTPRSFIASQGPLPPTFEDFWRMVWEQNSQSIVML
|..|..| .. . . . . |.|..||.|||| ||. |||.|| |.. ...|.||||||..| |.   ....|| ||||| |.|||||||||.... ||||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivml

TNLVELNKTKCHKYWPDKI---ETYGGVTVTLHQSELFA-DYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVP----------QYATAV----------
|. .| .|.||..|||...   ||.| ..|.| . |    ....||. |.| ... .| |.|.... |||.|||          ....            
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

-LAAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEAL
   |||.||||...|| .|.. ..  .||| . . .||| ||.||||.||||||. |.||..
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 333-568 1.1e-70 233.3 In-house 2-262 (263) alignment 
Range on Protein: 333-568
Range on HMM: 2-262/263.0
LETEYKKFNNGQ-QFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYdGTPRSFIASQGPLPPTFEDFWRMVWEQNSQSIVML
|..|..| .. . . . . |.|..||.|||| ||. |||.|| |.. ...|.||||||..| |.   ....|| ||||| |.|||||||||.... ||||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivml

TNLVELNKTKCHKYWPDKI---ETYGGVTVTLHQSELFA-DYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVP----------QYATAV----------
|. .| .|.||..|||...   ||.| ..|.| . |    ....||. |.| ... .| |.|.... |||.|||          ....            
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

-LAAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEAL
   |||.||||...|| .|.. ..  .||| . . .||| ||.||||.||||||. |.||..
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0042113 (Phosphotyrosine protein) phosphatases II 349-567 2e-70 232.3 In-house 2-242 (245) alignment 
Range on Protein: 349-567
Range on HMM: 2-242/245.0
EAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRsFIASQGPLPPTFEDFWRMVWEQNSQSIVMLTNLVELNKTKCHKYWP-
. |..|.||.|||| .|..|||.||.|  ..||.||||||||...||. ||. |||.||||| |.||||||.||.....|||||...||.. ||..||| 
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpk.fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl

DKIETYGGVTVTLHQSELFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQ-------------------YATAVL---AAGVERTGTYIVIDAML
. . |||..||||   | ..|| .||. ... . . ||.|...|.. ||| |||                      . ||    ||| ||||.|... ||
gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylml

EQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEA
||..| ..|.. . .  ||. ||..||| .|| |.. |.|| 
eqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
subfamily_PTPRB_pd Subfamily PTPRB 310-508 1.5e-68 226.0 In-house 4-202 (293) alignment 
Range on Protein: 310-508
Range on HMM: 4-202/293.0
SKPIPIALFPEYVAKMQANGGIRLETEYKKFNN-GQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGP
|||| .  | |.|.||.|.  .|.  ||..... |..   .||....|..|||| ||..|||||| |. ......||||||..|.||  .|| |||.|||
skpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgyn.sprefiatqGP

LPPTFEDFWRMVWEQNSQSIVMLTNLVELNKTKCHKYWPDK--IETYGGVTVTLHQSELFADYEIRTFILSKakRSGSRMVRQFHFTVWPDKGVPQYATA
|| |..||||||||..|. |||||.|||  |.||..|||..    .|| ..||| ..|   |. ||.. ..|  .. .| |||.||| ||| |||. ...
lpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektkt

VL
.|
ll
0045098 (Phosphotyrosine protein) phosphatases II 341-571 1.2e-67 223.6 In-house 18-275 (278) alignment 
Range on Protein: 341-571
Range on HMM: 18-275/278.0
NNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVlervngdedsDYINASFIHGYdgtPRSFIASQGPLPPTFEDFWRMVWEQNSQSIVMLTNLVELNKT
  |.   .. | .. |..|||| .|..||||||.          ||||||.|.||   |. ||| ||||| |..|||||.||.....|||||.||||.. 
llgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy...pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgre

KCHKYWPDKI-ETYGGVTVTLHQSELFADYEIRTFILSKA----KRSGSRMVRQFHFTVWPDKGVPQYA--TAVL----------A--------------
||..|||..  .|||..|||| . | . || .||...       .   || |...|.. ||| ||| .   . .|          .              
kcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllld

----------AGVERTGTYIVIDAMLEQAkkSRTVDIRNYLIALRKDRPH-MVQTKEQYLFIHSAVLEALTCG
          ||| ||||..... |||.    ..||. ...  ||. ||. .||..||| |.. ..|| | .|
sggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 349-508 2e-66 218.6 In-house 1-160 (239) alignment 
Range on Protein: 349-508
Range on HMM: 1-160/239.0
EAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRSFIASQGPLPPTFEDFWRMVWEQNSQSIVMLTNLVELNKTKCHKYWPD
|||.|  || ||||||||.|||||||||... |  |||||||... |||.|...||.|| . ..  |||||.|..    ||||| |.|  | |||.||||
eaakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd

KIETYGGVTVTLHQSELFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVL
    |  . |||...|.|||| ||||..|.  ..  | | |.||||||||||||||||||
stskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 311-509 3.3e-66 218.5 In-house 3-202 (319) alignment 
Range on Protein: 311-509
Range on HMM: 3-202/319.0
KPIPIALFPEYVAKMQANGGIRLETEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLP
..|... . |.. .....|   || |.|........ .. | |. ||.|||| ||.|||..||||  ..| |.||||||||| ||.   . ||| |.|| 
teievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqer.ekfiatqaPle

PTFEDFWRMVWEQNSQSIVMLTNLVELNKTKCHKYWPDKI-ETYGGVTVTLHQSELFADYEIRTFILSKAKRSG-SRMVRQFHFTVWPDKGVPQYATAVL
 |.|||||||||..|  .||||.|||  | |..||||..  |.|| ..||| . |  .||.|| . | |..    .|.| .|..| |||..||..||..|
ntiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatsll

A
.
d
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 350-509 6.5e-66 216.9 In-house 1-160 (239) alignment 
Range on Protein: 350-509
Range on HMM: 1-160/239.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRSFIASQGPLPPTFEDFWRMVWEQNSQSIVMLTNLVELNKTKCHKYWPDK
||.|  || ||||||||.|||||||||... |  |||||||... |||.|...||.|| . ..  |||||.|..    ||||| |.|  | |||.|||| 
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

IETYGGVTVTLHQSELFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLA
   |  . |||...|.|||| ||||..|.  ..  | | |.|||||||||||||||||| 
tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlg
0037934 (Phosphotyrosine protein) phosphatases II 348-566 1.9e-65 216.1 In-house 2-240 (243) alignment 
Range on Protein: 348-566
Range on HMM: 2-240/243.0
WEAARKPANKNKNRYANIVAYDHSRVVLervngdEDSDYINASFIHGYDgtpRsFIASQGPLPPTFED----FWRMVWEQNSQSIVMLTNLVELNKTKCH
.  |..|.|..|||| .|..||||||.|      |.||||||..| ...   | .||.||||| |.||    ||||.||.....|||||.||||.. ||.
fsiallpenlsknrysdilpydhsrvkl......egsdyinanliyvtp...r.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekca

KYWPDKIeTYGGVTVTLHQSELFADYEIRTFILSKAK-RSGSRMVRQFHFTVWPDKGVPQYATAVL-----------------------------AAGVE
.|||... |||..|||| ..| ..|| .||. |.  .    .|.|...|.. ||| |||.  . .|                              ||| 
qywpgev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvg

RTGTYIVIDAMLEQAkksrTVDIRNYLIALRKDRPH-MVQTKEQYLFIHSAVLE
||||.|... ||..     .||. ...  ||. ||. .||| .|| |.. |.||
RtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 311-508 3.9e-63 208.3 In-house 4-198 (315) alignment 
Range on Protein: 311-508
Range on HMM: 4-198/315.0
KPIPIALFPEYVAKMQANGGIRLETEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLP
.|||.  .  |||. .|.    .. .|.    || .| . |.|  ||.|||| ||.|||.||| |  .. |..|||.||.|| ||.  .| .||.|||..
qpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGyn.kkrryiaaqgpnv

PTFEDFWRMVWEQNSQSIVMLTNLVELNKTKCHKYWPDKIETYGGVTVTLHQSELFADYEIRTFilSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVL
 . .||||.|.|..   ||||||||| .| |. ||||||  .|| .|||. . | . .| .||.  |   ..  | | |.|.| ||| |||.|.....
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviyGkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplm
subfamily_PTPRK_pd Subfamily PTPRK 322-509 1.3e-61 203.2 In-house 13-197 (314) alignment 
Range on Protein: 322-509
Range on HMM: 13-197/314.0
VAKMQANGGIRLETEYKKFNNGqqfpWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPTFEDFWRMVW
.|..... |  .  ||. . .|    |.||.|  |..|||. .|.|||.|||.|  ..|| .||||||..| .|   |. ||. ||||. | .||||.|.
iallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsyk.rpaafivtqgPlqetvkdfWrlvy

EQNSQSIVMLTNLVELNKTKCHKYWPDKIETYGGVTVTLHQSELFADYEIRTFILSKA--KRSGSRMVRQFHFTVWPDKGVPQYATAVLA
..|. ||||||.|||  . || ||||.. |.|| . |.| ..|| |.. .|.| ..|.  . .. |.||||.|. ||| .||..||..|.
dencasivmltelvevgrvkClkyWPedtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllk
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 322-508 1.7e-61 202.8 In-house 6-193 (281) alignment 
Range on Protein: 322-508
Range on HMM: 6-193/281.0
VAKMQANGGIRLETEYKKFNN-GQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGtPRSFIASQGPLPPTFEDFWRMV
......|    . .||.|... |.. . .|.....|..|||| ||||||..||.... . ....|||||.|. ||.| .. .||.|||.| ....||.||
lkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykg.ekeyiatqgPvPaslvafWqmv

WEQNSQSIVMLTNLVELNKTKCHKYWPDKI--ETYGGVTVTLHQSELFADYEIRTFILsKAKRSGSRMVRQFHFTVWPDKGVPQYATAVL
|||. . |||.|. .| .| |||.||||.    .|| |||. ...|  | |  |.| | ... . .| |.|...| |||.|||. ....|
weqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkell
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 355-508 4.5e-60 197.8 In-house 2-156 (237) alignment 
Range on Protein: 355-508
Range on HMM: 2-156/237.0
ANKNKNRYANIVAYDHSRVVLERVNGDedSDYINASFIHGYDGTPRSFIASQGPLPPTFEDFWRMVWEQNSQSIVMLTNLVELNKTKCHKYWPD--KIET
 || ||||.||||||||||||.   ..  ||||||....|.||||...||.|||| .. .|||.|||...   ||||| |.| |. |||||||.  . ..
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGGVTVTLHQSELFADYEIRTFILSKA-KRSGSRMVRQFHFTVWPDKGVPQYATAVL
|| .||.|.. | |.|| .|...|||  .  . |.. |..||.|||.||||...|.|
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaall
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 619-738 6.1e-58 191.0 In-house 1-120 (250) alignment 
Range on Protein: 619-738
Range on HMM: 1-120/250.0
KSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHELDQEYPEYWPDH
|||...|||..|||..|||||.|.||.|.||..|.|||||||.|||....|.||||||.|| .|.|||||||.....||||||..|.| ...|..|||  
ksvakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPve

GPTKYGHIGVSVLSKQEKGD
...|||.. ||.|||.|..|
kaekyGdvtvsllskeefad
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 311-604 1.7e-57 189.6 In-house 2-272 (392) alignment 
Range on Protein: 311-604
Range on HMM: 2-272/392.0
KPIPIALFPEYVAKMQANggIRLETEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLP
.|||.| || .| | . .    .  |.. . . . .|  .|.|. |..|||| ||. || .||.|| ..   ||||.|||.|...|   ...|||||| .
qpipvaqfpafveknrhs..alffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdne.kayiasqgpna

PTFEDFWRMVWEQNSQSIVMLTNLVELNktkchkywpdkietyggvtvtlhqselfadyeirtfilskaKRSGSRMVRQFHFTVWPDKGVPQYATAVL--
 ...||||||...|  .|.|.|.| | .                                         |    | | ||||| ||||.||......|  
aslddfwrmvfqenvttiamvtklkegd.........................................kgddartvaqfhftewPdkdvpkhtssllkf

-------------------AAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEALTCGNTEIQSENFNQTTQKLAS
                   .||| |||  | ||... .|||.| ||. |..  .|. ||.|||||||| ||. |||| |   || |    | .  |.| .
ikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlst

VNRKFQMTGYALEFQ
       .    ||.
ssdGdvrskqlkefr
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 320-506 2.6e-57 189.1 In-house 10-196 (288) alignment 
Range on Protein: 320-506
Range on HMM: 10-196/288.0
EYVAKMQANGGIRLETEYKKF-NNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLPPTFEDFWR
..|||..|..   .. ||..  . ...   .|.|.. |..|||| ||..||. || |. ..  ...||||||.|.|.... . .||.||||. | .|||.
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkk.kkyiatqgPladtvndfWe

MVWEQNSQSIVMLTNLVELNKTKCHKYWPDKIE--TYGGVTVTLHQSELFADYEIRTFILSkaKRSGSRMVRQFHFTVWPDKGVPQYATA
.|.|.... |||||.||| .||||..||||. .   || ||||| .|.   |.  |...|   |. . . . |.....|||.|||. .. 
lvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskap
subfamily_Ptp69D_pd Subfamily Ptp69D 318-508 7.4e-57 187.8 In-house 9-205 (307) alignment 
Range on Protein: 318-508
Range on HMM: 9-205/307.0
FPEYVAKMQANGGIRLETEYKKFN-NGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLPPTFEDF
 .| . . . .    |. ||.| . .  .   ... |  |. |||| .|.|.|. ||.|...||.|||||||||||.||. . ..|||.|.|.  | .||
leealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykek.kkfiaaqdPveatigDf

WRMVWEQNSQSIVMLTNLVELNKTKCHKYWP-DKIETYGGVTVTLHQSELFADYEIRTFILSKAKRSG-----SRMVRQFHFTVWPDKGVPQYATAVL
|||..||... ||||.|| | |. ||.|||| ...  || . |.| ..|   || ||.. .|| | ..     || | |.|.| |.|  ||. |...|
WRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargll
subfamily_PTPN6_pd Subfamily PTPN6 340-508 7.8e-55 181.0 In-house 38-209 (306) alignment 
Range on Protein: 340-508
Range on HMM: 38-209/306.0
FNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLErVNGDEDSDYINASFIH-GYDGTPRSFIASQGPLPPTFEDFWRMVWEQNSQSIVMLTNLVELN
 .. ...  . ..|| ||.|||| ||. .||.||.|.  ..  .||||||..|.    |. .|.||.|| |. | .|||||||..||. |||.|. || .
eeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErg

KTKCHKYWPDKIE--TYGGVTVTLHQSELFADYEIRTFILSK-AKRSGSRMVRQFHFTVWPDKGVPQYATAVL
| || .||||. |  .|| ..||  ...  |||..|.. .||  | . .| |.|.||..|||.|||.   |||
kekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavL
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 333-507 9.6e-55 181.1 In-house 36-207 (319) alignment 
Range on Protein: 333-507
Range on HMM: 36-207/319.0
LETEYKKFNNGQ--QFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPTFEDFWRMVWEQNSQSIVM
|| |...  .        . |  . ||.|||. ||.|.|...| |||..| | ||||||||. ||   .  .||.||||. | .|||||.||.|. .||.
levefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyq.rkdkyiaaqGPldntladfWrmiweyncstivl

LTnlvelnKTKCHKYWPDKI-ETYGGVTVTLHQSELFADYEIRTFILSK-AKRSGSRMVRQFHFTVWPDKGVPQYATAV
||      | || .||| || ....   | ..  |  |.| .| . ||. .|  . | ..||||  |||.|||.|.. .
lt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdl
subfamily_PTPN9_pd Subfamily PTPN9 318-508 2.6e-54 179.3 In-house 6-196 (297) alignment 
Range on Protein: 318-508
Range on HMM: 6-196/297.0
FPEYVAKMQANGgirLETEYKKFNNGQ-QFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPTFEDF
. .|| ... .|   |  ||..  | . .   .|....|| .||||.... ||..||||..|..|| ||||||.|. ||   ...||| ||||. |..||
lvayvkekgkrG...lskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGyk.qkkafiatqGplkktvsdf

WRMVWEQNSQSIVMLTNLVELNKTKCHKYWP---DKIETYGGVTVTLHQSELFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVL
|||||||.   ||| | .||  . || .|||   .. . .| ..|.  . |   ||..|.. ....| . || |  | |. ||| |||. |...|
WrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaasll
subfamily_PTPN12_pd Subfamily PTPN12 332-508 5.1e-54 178.1 In-house 16-193 (290) alignment 
Range on Protein: 332-508
Range on HMM: 16-193/290.0
RLETEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLPPTFEDFWRMVWEQNSQSIVML
.| .. .|. . .... ||..|. |..|||| .|. ||.|||.|.. ...|.||||||.||.| .|.  ..||.||||| | .|||||.||.| . .||.
klkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegk.leyiaaqgPLpktlddfWrmiweknveivvma

TNLVELNKTKCHKYWPDKIE---TYGGVTVTLHQSELFA-DYEIRTFILSKAkrSGSRMVRQFHFTVWPDKGVPQYATAVL
 ..|||.|.||..|||.. |   ..| ..|||.. . .  |. |||. . .   . ||.|.|||.| |||.|||. |. .|
CrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksll
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 352-507 9.7e-54 177.8 In-house 21-171 (284) alignment 
Range on Protein: 352-507
Range on HMM: 21-171/284.0
RKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPTFEDFWRMVWEQNSQSIVMLTnlvelnKTKCHKYWPDKI-
  . ||.|||. .|.|.|...| |||. | | ||||||||| ||   .  .||.||||. | .|||||.||.|. .||.||      | || .||| || 
nldqnkdknrighilafdknvvklerliGeefsdyinasfitGyq.rkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkiv

ETYGGVTVTLHQSELFADYEIRTFILSK-AKRSGSRMVRQFHFTVWPDKGVPQYATAV
....   | ..  |  ..| .| . ||. .|  . | .|||||  |||.|||.|.. .
ikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 311-508 1.3e-53 177.2 In-house 2-201 (305) alignment 
Range on Protein: 311-508
Range on HMM: 2-201/305.0
KPIPIALFPEYVAKMQANGGIRLETEYKKFNNGqQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLP
|.| .. . .|. .....    ||..||.. .  . . .  .| |||.|||...|. .|..|. |   . ..||||||||...||..   ..|..||||.
kiialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrk.kkyivaqgPlk

PTFEDFWRMVWEQNSQSIVMLTNLVELNKTKCHKYWPDKIET---YGGVTVTLHQSELFADYEIRTFILSK-AKRSGSRMVRQFHFTVWPDKGVPQYATA
 | .||||...|   ..|||||.||| .| ||..|||...     .| ..|.|.... ..|| .| . .|.  . . || | |...| |||.||||.||.
ntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfats

VL
.|
ll
Y_phosphatase Protein-tyrosine phosphatase 356-508 5.3e-53 175.2 Pfam-A 1-156 (235) alignment 
Range on Protein: 356-508
Range on HMM: 1-156/235.0
NKNKNRYANIVAYDHSRVVLervNGDED-SDYINASFIHGYDgTPRSFIASQGPLPPTFEDFWRMVWEQNSQSIVMLTNLVELNKTKCHKYWP---DKIE
||.|||| .|..||..|| |   .|.|. ||||||....||. ....|||.||||. |.||||||||......|||||.|.| ...||..|||   .. .
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

TYGGVTVTLH-QSE-LFADYEIRTFILSKAKRS-GSRMVRQFHFTVWPDKGVPQYATAVL
||| ..|.|  ...   ..| .|.. |.| |..  .|.|.|.|.| |||.|||. ....|
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespksll
Y_phosphatase Protein-tyrosine phosphatase 356-508 5.3e-53 175.2 In-house 1-156 (235) alignment 
Range on Protein: 356-508
Range on HMM: 1-156/235.0
NKNKNRYANIVAYDHSRVVLervNGDED-SDYINASFIHGYDgTPRSFIASQGPLPPTFEDFWRMVWEQNSQSIVMLTNLVELNKTKCHKYWP---DKIE
||.|||| .|..||..|| |   .|.|. ||||||....||. ....|||.||||. |.||||||||......|||||.|.| ...||..|||   .. .
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

TYGGVTVTLH-QSE-LFADYEIRTFILSKAKRS-GSRMVRQFHFTVWPDKGVPQYATAVL
||| ..|.|  ...   ..| .|.. |.| |..  .|.|.|.|.| |||.|||. ....|
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespksll
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 353-582 5.6e-51 168.4 In-house 45-293 (439) alignment 
Range on Protein: 353-582
Range on HMM: 45-293/439.0
KPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPTFEDFWRMVWEQNSQSIVMLTNLVELNKtkchkYWPDKIET
.  .. |||| ...|.||.||.|. . |   | |||| .|.||  ... .||.|||   | .||||.|.|...  |||||||||  |     ||| . |.
qeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyy.ddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaev

Y-GGVTVTLHQSELFADYEIRTFILSKAKR--SGSRMVRQFHFTVWPDKGVPQYATAVL----------------------AAGVERTGTYIVIDAMLEQ
. | ..|   .   . .| || | . . .      | | |||.. |||| ||  |. ||                      .||| |||| | .|  |||
cygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeq

AKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEALTCGNTEIQSENFNQ
 |    |||.  .  |||.| .|||.  ||.||. |||| .  |.. .. ..|..
lklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefkk
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 311-508 7.9e-51 167.7 In-house 1-196 (315) alignment 
Range on Protein: 311-508
Range on HMM: 1-196/315.0
KPIPIALFPEYVAKMQANggIRLETEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGtPRSFIASQGPLP
.|||.| || .| | .      .  |.. . . . ..  .||.. | .|||| ||. .|..||.|| .. . ||||||||.|...|   ...|||||||.
qpipvaqfpafvnknrht..alfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdd.dkayiasqgPlk

PTFEDFWRMVWEQNSQSIVMLTNLVELNKTKCHKYWPD---KIETYGGVTVTLHQSELFADYEIRTFILSKAKRsgSRMVRQFHFTVWPDKGVPQYATAV
 . .||||||....  .|||.|.. | .| || .||||   .   .| . |.| . |  .|  .| ... |..   || | ||.|| ||||||.. ....
asvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrksee..srtvtqfqftewPdkGvdkqtssl

L
|
l
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 348-508 4.2e-50 165.4 In-house 20-184 (274) alignment 
Range on Protein: 348-508
Range on HMM: 20-184/274.0
WEAARKPANKNKNRYANIVAYDHSRVVLERVNGDE-DSDYINASFIHGYDGTPRSFIASQGPLPPTFEDFWRMVWEQNSQSIVMLTNLVELNKTKCHKYW
 |  . . ...|||| .|.  ..|||.||. .... ||.|||| .|.|||.. . ..| ||||| | .|||||......| |||||.| | |..||..|.
qeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyf

PDKIET-----YGGVTVTLHQSELFADYEIRTFILSKAKRsgSRMVRQFHFTVWPDKGVPQYATAVL
||....     ||.| .. ..     ||..|...|....|  .| |  . .| |||. .|. |...|
Pdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantll
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 312-508 1.8e-49 163.2 In-house 1-195 (515) alignment 
Range on Protein: 312-508
Range on HMM: 1-195/515.0
PIPIALFPEYVAKMQANggIRLETEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGtPRSFIASQGPLPP
|.|.| || .|.| .      .  |.. .   . .|   |..  | .|||| ||. || .|| || .| . .|||.|||.|...|   ...||||||.. 
plplaqfPafvnknrht..tlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdn.dkayiasqgPnka

TFEDFWRMVWEQNSQSIVMLTNLVELNKTKCHKYWPDK---IETYGGVTVTLHQSELFADYEIRTFILSKAKRsgSRMVRQFHFTVWPDKGVPQYATAVL
. .||||.|...|   |.|.|.| | .| || ||||||      .| . | |   |  ..  .|.. . | .   || | ||||| |||||||. ....|
svddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssll
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 320-508 3.1e-48 159.6 In-house 12-201 (325) alignment 
Range on Protein: 320-508
Range on HMM: 12-201/325.0
EYVAKMQANGGIRLETEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLPPTFEDFWRM
|.| | .|.    .  |..   . .    ..| ||.||.|||. |.||.|.||||||  . | .|||||||... . .    |.|.| ||. | .|.||.
ehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkk.dvflaaqaPltatindlWrl

V--WEqnsQSIVMLTNLVELNKTKCHKYWPDK---IETYGGVTVTLHQSELFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVL
|  |.    |.|...| ..|.| .| .|||..     |.||. | |   | ..||  | . . ..|.  .| |.||..  |.| ||... ....
vldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatli
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 313-508 9.5e-48 157.5 In-house 2-202 (290) alignment 
Range on Protein: 313-508
Range on HMM: 2-202/290.0
IPIALFPEYVAKMQANGGIRLETEYKKFNNGQ-QFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDED--SDYINASFIHGYDGTpRSFIASQGPL
||.  | |.||. .|.|  . ....|....|. ..  . .  . ||..||.|||| ||  |..| ...|..|   .||||..|.||    ...|| |||.
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykek.kqyiatqgpv

PPTFEDFWRMVWEQNSQSIVMLTNLVELNKTKCHKYWPDK-IETYGGVTVTLHQSELFADYEIRTFILSKAKR-SGSRMVRQFHFTVWPDKG-VPQYATA
. |  |||...|....  |||||| .| .|.||..||||.  ..|| ....|.. | . .| .|.. . . .    ...| |...| |...| |....| 
sntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqti

VL
.|
ll
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 311-503 5.3e-47 155.4 In-house 8-195 (297) alignment 
Range on Protein: 311-503
Range on HMM: 8-195/297.0
KPIPIALFPEYVAKMQANGGirLETEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGtprSFIASQGPLP
.|||.. |. .| | .       . |..   . . .|   |.|  | .|.||.||. || ||| |. || | ||||.||||..|.      .|..| | .
rpiplsdfatlvqknrhtdv..fseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh...rlittqmPmk

PTFEDFWRMVWEQNSQSIVMLTNLVELNKtKCHKYWPDK-IETYGGVTVTLHQSELFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQY
 | .|||.||.... . ||||... | .| || .||.|| . |.| |.|.|.  .    .  |.. ..| |    |.|.|..|. |||| |.. 
atvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverk
subfamily_PTPN1_pd Subfamily PTPN1 341-508 2.9e-46 152.5 In-house 17-185 (290) alignment 
Range on Protein: 341-508
Range on HMM: 17-185/290.0
NNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERvngdEDSDYINASFIHgYDGTPRSFIASQGPLPPTFEDFWRMVWEQNSQSIVMLTNLVELNKT
.. ..|| ..|..|.|.|.||| ..  |||||..|||    .| ||||||...  .   ||.| .||||| | . ||.|||||.|...||| ..|| ...
keasdfptreaklpenrnlnryrdvspydhsrikler....adndyinaslve.leeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqi

KCHKYWPDKIE----TY--GGVTVTLHQSELFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVL
||..||| . |    ..    ..|.| . |    | .|.. | . |   .| . .||.| ||| |||.  .| |
kcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaafl
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 313-508 6.8e-46 151.5 In-house 2-197 (287) alignment 
Range on Protein: 313-508
Range on HMM: 2-197/287.0
IPIALFPEYVAKMQANGGIRLETEYKKFNNGQQFPWEAARK--PANKNKNRYANIVAYDHSRVVLErvngDEDSDYINASFIHGYDGTpRSFIASQGPLP
||.  | |.||| .|.|    .. .. ... .| . |   .  . ||.|||...|. .|  ||.|.    .|. |||||.|| ||    . ||....|. 
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykek.kafiiaesPmf

PTFEDFWRMVWEQNSQSIVMLTNLVELNKTKCHKYWPDKI-ETYGGVTVTLHQSELFADYEIRTFILSKAK-RSGSRMVRQFHFTVWPDKG-VPQYATAV
 |  .||......| . ||||... | .. .|..|||..   ..|  ...| . |  |.| .|.. . . .  .  ..|.|...| |...| |....| .
ntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtil

L
|
l
subfamily_PTPN3_pd Subfamily PTPN3 345-508 1.1e-45 150.8 In-house 30-194 (280) alignment 
Range on Protein: 345-508
Range on HMM: 30-194/280.0
QFPWEAARKPANKNKNRYANIVAYDHSRVVLErvngDEDSDYINASFIHG-YDG--TPRSFIASQGPLPPTFEDFWRMVWEQNSQSIVMLTNLVELNKTK
.   .|||||.| .|||| .|..||. || |.    ....|||||...    ..  .   .||.||||. | .|||.|||||.|. |||||.|||  ..|
glaisaarkpenlsknryrdilpydatrvklk....esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvk

CHKYWPDKIE--TYGGVTVTLHQSELFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVL
||.|||.. .  .||. .|......    | .| ..|.... . .|.. |. .. |||.|||. .. .|
ChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadfl
0051429 (Phosphotyrosine protein) phosphatases II 384-570 7.2e-44 145.8 In-house 4-226 (272) alignment 
Range on Protein: 384-570
Range on HMM: 4-226/272.0
SDYINASFIHGYdGT---PRSFIASQGPLPPTFEDFWRMvWEQNSQSIVMLTNLVELNKTKCHKYWP-------------DKIETYGGVTVTLHQSELFA
|.||||... || |    |. ...|.|||| | .||||. .|..  .||.|....|... ||..|||             .   .|| ..|||.. ||. 
sgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

DYEIRTFILSKA-KRSGSRMVRQFHFTVWPDKGVPQ--YATAVL------------AAGVERTGTYIVIDAMLEQAKKSRTVD--------IRNYLIALR
|| .|...|..  . . .|.|...|.| ||| ||||  . ...             .||. ||||..... .|..  ..  ||        .....  ||
dyilrellltlllsagearevmhlhytdwpdhgvpqeallellellldggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelr

KDRPHMVQTKEQYLFIHSAVLEAlTC
. ||..||| |||||.. |.||.  .
aqrpgavqteeqylflyeallel.lr
subfamily_PTPN23_pd Subfamily PTPN23 331-504 1.3e-42 140.6 In-house 15-190 (288) alignment 
Range on Protein: 331-504
Range on HMM: 15-190/288.0
IRLETEYKKFNNGQQF-----PWEAARkpANKNKNRYANIVAYDHSRVVLErvngDEDSDYINASFIHGYDGTPRSFIASQGPLPPTFEDFWRMVWEQNS
  |....|.... |.         .|.   . .|||. .|. |||.||.|.    ..  |||||||...   .  .|||.|.||..|  |||.||.|| |
taldkkfkeleqkqdkearkrsiaiak..lyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqks

QSIVMLTNLVELNKTKCHKYWPDK---IETYGGVTVTLHQSELFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYA
. ||||..  ||.|.|...||| .    ...| ..|||.. .    .  |...|.  . .  ..|.  ..| ||. |||.  
sviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasP
subfamily_PTPRN_pd Subfamily PTPRN 333-508 3.7e-42 139.1 In-house 31-210 (297) alignment 
Range on Protein: 333-508
Range on HMM: 31-210/297.0
LETEYKKFNNGQQFP--WEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRSFIASQGPLPPTFEDFWRMVWEQNSQSIVM
|| |.. . . .. |   |.|... | .|||......|||||| |.. . .|.|||||||.|   |    ..||.||||. |  |||.||||| .  ||.
lekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivn

LTNLVELNKTKCHKYWPDK-IETYGGVTVTLHQSELFA-DYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVL
||.| | . ..|..||||.  |.|.   | |    ... || .|.| |   . | .| | ||||  ||..|||  | ..|
ltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksll
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 350-504 1.1e-41 137.7 In-house 14-171 (270) alignment 
Range on Protein: 350-504
Range on HMM: 14-171/270.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRSFIASQGPLPPTFEDFWRMVWEQNSQSIVMLTNLVELNKTKCHKYWPDK
      .|. ||||.|.   ..||.||... |. . |||| ...|.|| ....||..|||| | ..||||.||.....|||.|.|.| ...|| .||| .
lpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpae

IET-----YGGVTVTlHQSELFADYEIRTFILSKAKRSGSRMVrQFHFTVWPDKGVPQYA
 ..     .| ..|.  .||  ..  |.| .  . | .  |.|  |... |||.|||. .
pkekvkledgkikvl.alseekeegyiltrlrleekgeerrlv.HfwyntWpdhgvpree
0050432 (Phosphotyrosine protein) phosphatases II 562-736 2.2e-41 137.6 In-house 6-178 (308) alignment 
Range on Protein: 562-736
Range on HMM: 6-178/308.0
SAVLEALTCGNTEIQSENFNQTTQKLAS-VNRKFQMTGYALEFQRLNSVTSheipAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLhkehaDEESDYINA
.|.||.|....|.|. ...... ..|.  ..........  ||..|.||.      .| ||.. |.| .|||..||... ..|| |     ||.||||||
dallelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkp....lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInA

VFLHAH--RGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHELD-QEYPEYWPDH---GPTKYGHIGVSVLSKQEK
 . . .  . ...|||||.|| .||||||||| .... .||||..|.| . . ...|||.    |...||.. | .|| ...
syvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevl
0041856 (Phosphotyrosine protein) phosphatases II 356-574 3.1e-41 136.3 In-house 1-177 (182) alignment 
Range on Protein: 356-574
Range on HMM: 1-177/182.0
NKNKNRYANIVAYDHSRvvlervngdeDSDYINASFIHGYDGTPRsFIASQGPLPPTFEDFWRMVWEQNSQSIVMLTnlvelnktkCHKYWPDKIetygg
|..|||| .|. |||||          |.|||||... |.  . | ||| ||||. |..||.||..|.. ..||.||         .. |||..      
nldknrysdilpydhsr..........dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywpell.....

vtvtlhqselfadyeirtfilskakrsgSRMVRQFHFTVWPDKGVPQyATAVLA-----------------AGVERTGTYIVIDAMLEQakksrTVDIRN
                             |.. |.... ||| |||     .|.                 ||| ||||..... |...      |....
............................erlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl.....gvslee

YLIALRKDRPHMVQTKEQYLFIHSAVLEALTCGNTE
 .  .|. ||.||.| .|| |.. |.|| | ...|.
avklvrsrRpgmvitpnqyfflqlallellllkktr
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 339-505 3.8e-41 135.7 In-house 21-188 (287) alignment 
Range on Protein: 339-505
Range on HMM: 21-188/287.0
KFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLErVNGDEDSDYINASFIHGYDGTpRSFIASQGPLPPTFEDFWRMVWEQNSQSIVMLTNLVELN
.  ..  . . || . |. .|||||... .|..||.|   .|.  |||||| .. .|     .|||.|||.. |  ||||.|.|..| |....|  ||  
edsesstatfkaaeelaavkknryadvlPiddtrvlls.aegelGsdyinanyvasytdd.eafiaaqgPiaatvrdfwravletrsasvitmtreveea

KTKCHKYWPDKIE--TYGGVTVT-LHQSELFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYAT
. ||.||||..      || .|. | .. .  .| .|.. | ...   .|.|.|...  ||||...  | 
rlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtav
subfamily_PTPN13_pd Subfamily PTPN13 336-507 7.8e-41 135.1 In-house 16-188 (273) alignment 
Range on Protein: 336-507
Range on HMM: 16-188/273.0
EYKKFNNGQ-QFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGdedsdYINASFIHGYDGTP-RSFIASQGPLPPTFEDFWRMVWEQNSQSIVMLTN
|.|.... . .   | ..| .||.|||| |.. ||..|| |.   |     |||||.|.   |    ..||.||||| | .|||.|||||... |.|.|.
efkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtl

LVELNKTKCHKYWPDK----IETYGGVTVTLHQSELFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAV
 .| .| |||.|||..    .  .. ..|.| . .   .. .|.. ... . . || | ...|. ||| |||. |. .
ekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaael
0051299 (Phosphotyrosine protein) phosphatases II 571-736 1.1e-40 135.4 In-house 1-159 (288) alignment 
Range on Protein: 571-736
Range on HMM: 1-159/288.0
GNTEIQSENFNQTTQKLAsvnrKFQMTGYALEFQRLNSVTSHeipaEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRN
|.|||. |.. .. .||     . ..||.. ||..| |.. .     . |..  |.||.|||.|||......|| |. .. .|.|||||| ... ..  .
gdteisveellklvlkll....angltglleefeellsllpd....ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkr

AFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHELD-QEYPEYWPDHGPTKYGHIGVSVLSKQEK
.|||||.|| .||||||||| .... .||||..|.||. . .. |||..|...||.| |  || ...
kfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevl
subfamily_CG7180_pd Subfamily CG7180 350-508 1.2e-39 130.8 In-house 36-204 (296) alignment 
Range on Protein: 350-508
Range on HMM: 36-204/296.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPTFEDFWRMVWEQNSQSIVMLTNLVELNKtKCHKYWPDK
.. .  |..|||. ..| ||. |||||...|.|.||||||... ..   .. .|  ..|   | ..|||.|........|.||.  . .| ....||| |
gglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsfl.kkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnk

-IETYGGVTVTLHQSELFADYEIRTFILSKA----------KRSGSRMVRQFHFTVWPD-KGVPQYATAVL
  | || . | . ... .|. .|||| | |                |.|..|..|.|.  . ||  ..|..
skeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnali
subfamily_CG42327_pd Subfamily CG42327 354-509 4.2e-36 119.2 In-house 26-185 (319) alignment 
Range on Protein: 354-509
Range on HMM: 26-185/319.0
PANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRSFIASQGPLPPTFEDFWRMVWEQNSQSIVMLTNLVELNKTKCHKYWPDK----
.. |.|.|..|.|   ..||||.|.  |. . |..||.. ||| .| |.||.| .|  .  ||||.||||.|. || ||.| ||   .| .|.| |    
vtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketld

-IETYGGVTVTLHQSELFADYEIRTFILSKAKRSGSRMVRQFHFtVWPDKGVPQYATAVLA
  ..|| . ||| . |    | | |..| . ... || .  . .  |.. .||   .|..|
ntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaalia
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 598-735 1.2e-35 118.1 In-house 21-155 (318) alignment 
Range on Protein: 598-735
Range on HMM: 21-155/318.0
GYALEFQRLNSVTSHeiPAEEKSvgEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGT
 .  |..||. ....  ... ||   || | .|||. .|.| ...|| |.. . .|.|||||| ..  .| ..|.||.| || ||.||||||| . .  .
llseeyerlsrseet..vtslks..lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsav

IVMLNSLHELDQ-EYPEYWPDHGPTKYGHIGVSVLSKQE
||||  ..|  .     |||..|...||.. | . .. |
ivmltqeeergkakvhryWPskgsrsygklvvelkeeve
0047943 (Phosphotyrosine protein) phosphatases II 590-735 1.3e-35 118.6 In-house 5-146 (273) alignment 
Range on Protein: 590-735
Range on HMM: 5-146/273.0
VNRKFQMTGYALEFQRLNSVTSheipAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLhkehADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRM
.......|....||..| |..       ..||.. |.|..|||..||......|| |     |..|||||| ..  ..  ..|||||.|| .||||||||
lekllgltllleefelllslkp....lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrm

VTDYDIGTIVMLNSLHELDQ-EYPEYWPDHG---PTKYGHIGVSVLSKQE
| .... .||||..|.||..  .. |||. |   ...||.. | .|| ..
vweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet
subfamily_PTPN14_pd Subfamily PTPN14 345-505 1.8e-35 117.4 In-house 38-203 (300) alignment 
Range on Protein: 345-505
Range on HMM: 38-203/300.0
QFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNgDEDSDYINASFIHGY-DGTPRSFIASQGPLPPTFEDFWRMVWEQNSQSIVMLTNLVELNKTKCH
.   ..|. | |..|||. ... |...|| |   . .....||||| |.    |. ||.|..||||. | .|||.|||||. | |||||.  |  |.|..
dallstaklpenaeknrfkdvlPyednrvelsptk.enstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksf

KYWPDK-----IETYGGVTVTLHQSELFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYAT
||.|..       ..|   || . ||    .  ... |     .  | |  . .| |||.|||.  .
kyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvk
0040438 (Phosphotyrosine protein) phosphatases II 594-736 2.6e-35 117.6 In-house 15-153 (317) alignment 
Range on Protein: 594-736
Range on HMM: 15-153/317.0
FQMTGYALEFQRLNSVtsheiP-AeEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTD
 ..|.   ||..| |.     .   . ||.| |.| .|||..||. . ..|| |. .  |..|||||| . . .. ...|||||.|| .||||||||| .
sdftalleefedllsl.....kld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvwe

YDIGTIVMLNSLHELD-QEYPEYWPDHGPTKYGHIGVSVLSKQEK
.....||||..| ||. . . .|||. ....||.. | .|| .|.
qgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeel
0046845 (Phosphotyrosine protein) phosphatases II 601-736 2.6e-35 117.6 In-house 4-145 (284) alignment 
Range on Protein: 601-736
Range on HMM: 4-145/284.0
LEFQRLNSVTSHEIpaEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHAD-EESDYINAVFLHAH-----RGRNAFIATQHPLLETVEDFWRMVTDYD
 ||..|.|.| . .   . ||.  |.||.|||..||......|| |. .. | |.|||||| ... .     . ...|||||.|| .||||||||| ...
eefeellsltvkll..lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

IGTIVMLNSLHELDQ-EYPEYWPDHG-PTKYGHIGVSVLSKQEK
. .||||..|.| ..  .. |||. | . .||.. | .||...|
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevk
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 591-737 2.9e-35 116.7 In-house 13-159 (288) alignment 
Range on Protein: 591-737
Range on HMM: 13-159/288.0
NRK--FQMTGYALEFQRLNSVTSHeipaEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWR
..|   . ||.  |.. | .. ..    .....|....| .|||. .|....  || |.| .  ...||||| ... .......|||| || .||.|||.
akksarnrtgfseeynsLaalekt....ksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWe

MVTDYDIGTIVMLNSLHELD-QEYPEYWPDHGP-TKYGHIGVSVLSKQEKG
.| .... |||||..| | . ..  ||||| .  ..||.. | .....|..
lvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskele
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 326-505 5.8e-35 115.4 In-house 13-209 (301) alignment 
Range on Protein: 326-505
Range on HMM: 13-209/301.0
QANGgirLETEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNG--DEDSDYINASFIHGYDGTpRSFIASQGPLPPTFEDFWRMVWEQ
..|.   .| .||. ..|.. . .   . .||. ||. ||. ||. |..|.  .       .|||||.|.||  . . |||.|||.  |  ||||..|..
hsnk...feeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysek.kkfiaaqgpmkktlvdfWrliwqe

NSQSIVMLTNLVELNKTKCHKYWPD---KIETYGGVTVTLHQSELFADYEIRTFILSKAK---------------RSGSRMVRQFHFTVWPDKGV-PQYA
  .||||.||| |  |.||..|||.   . |..| .||||...  . |. || . .   .               .  |. | |.. | ||. || ....
kpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvrepr

T
|
t
0049772 (Phosphotyrosine protein) phosphatases II 346-570 1.2e-34 115.9 In-house 36-282 (314) alignment 
Range on Protein: 346-570
Range on HMM: 36-282/314.0
FPWEAARKPANKNKNRYANIVAYDhSRVVLERVNGDeDSDYINASFIHGYdgtpRSFIASQGPLPPTFEDF----------WRMV--WEQNSQSIVM---
. . .|....|..|||| .|. .| .||.| ..... .|||||||...|.    ..|||.||||. |..||          ||||  ...|.  |||   
ltilvadlflnrdknryldilpad.nrvilpglpvs.gsdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrd

------------------LTNLVELNktkcHKYWPDKIETYGgvtvtlhqselfadyeirtfilS-------KakrsgSRMVRQFHFTVWPDKGVP----
                  |..| ...      ...  .|..                       .             .|.. ... . .|| ..|    
evladelsrLdaAlgKtpllildgng....neptaadlellk......................eelydpelf.....erlgikylripvpDgsaplled

-----------QYATAVL---AAGVERTGTYIVIDAMLEQAKksrtVDIRNYLIALRKDRP-----HMVQTKEQYLFIHSAVLEALTC
           .  ..||   .||. ||||..|.. .. . .    |...  |  .|. ||     ..... |||.||. |.||.|  
fdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefilealleylkf
0039614 (Phosphotyrosine protein) phosphatases II 589-736 1.5e-34 115.2 In-house 24-166 (297) alignment 
Range on Protein: 589-736
Range on HMM: 24-166/297.0
SVNRKFQMTGYALEFQRLNSVTSheipaEeKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHA-DEESDYINAVFLHAHRG-RNAFIATQHPLLETVEDF
 .......|.. |||..| |..      . .|... |.| .|||..||......|| |. |   |..|||||| ..  ..   ..|||||.|| ||||||
llekansktllllefeellslkp.....d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedF

WRMVTDYDIGTIVMLNSLHELDQEYPEYWPDHGPtKYGHIGVSVLSKQEK
|||| .... .||||..| ||.. ...|||. |  .||.. | .|. ...
wrmvweqgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkvehl
0036941 (Phosphotyrosine protein) phosphatases II 589-735 1.7e-34 114.9 In-house 5-146 (297) alignment 
Range on Protein: 589-735
Range on HMM: 5-146/297.0
SVNRKFQMTGYALEFQRLnsvtSHEIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLhkehADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWR
 ..........  ||..|     . ..  ..||.. |.||.|||..||......|| |     ||.|||||| ..  ..  ..|||||.|| .|||||||
llekllflalllkefeel....lpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWr

MVTDYDIGTIVMLNSLHELDQ-EYPEYWPDH--GPTKYGHIGVSVLSKQE
|| .... .||||..| ||.   ...|||.   .. .||.. | .|| ..
mvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvev
DSPc_SM00195 602-735 5e-34 113.2 In-house 5-137 (263) alignment 
Range on Protein: 602-735
Range on HMM: 5-137/263.0
EFQRLNSVTSHEipaeEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVML
||..|.. ||..    |.. .|...| .|||...|.  .. || |.||. .|.|||||| ..  .. ....||||.|| .|||||||||.. .. .||||
efekleestspk....etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

NSLHEL-DQEYPEYWPDH--GPTKYGHIGVSVLSKQE
..  |   ..  .|||.   |....|.| | . ....
teeeengkekcdrywpeesggketfgkisvklvevek
PTPc_SM00194 602-735 5e-34 113.2 In-house 5-137 (263) alignment 
Range on Protein: 602-735
Range on HMM: 5-137/263.0
EFQRLNSVTSHEipaeEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVML
||..|.. ||..    |.. .|...| .|||...|.  .. || |.||. .|.|||||| ..  .. ....||||.|| .|||||||||.. .. .||||
efekleestspk....etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

NSLHEL-DQEYPEYWPDH--GPTKYGHIGVSVLSKQE
..  |   ..  .|||.   |....|.| | . ....
teeeengkekcdrywpeesggketfgkisvklvevek
0043336 (Phosphotyrosine protein) phosphatases II 592-735 5.1e-34 113.4 In-house 15-153 (278) alignment 
Range on Protein: 592-735
Range on HMM: 15-153/278.0
RKFQMTGYALEFQRLNSVTSheipaEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVT
 .   |.. |||..|.|..      ...|... |.| .|||..||......|| |. .  |. |||||| ..  ..  ..|||||.|| |||||||||| 
llnlktllllefeellsfkl.....dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvw

DYDIGTIVMLNSLHELD-QEYPEYWPdHGPTKYGHIGVSVLSKQE
.... |||||..| ||. . . .|||  |...||.. | .|. ..
elgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeeh
0036282 (Phosphotyrosine protein) phosphatases II 384-561 7.4e-34 112.3 In-house 2-163 (174) alignment 
Range on Protein: 384-561
Range on HMM: 2-163/174.0
SDYINASFIHGYDGTPrSFIASQGPLPptfedFWRMVWEQNSQSIVMLTNLVELNKTKCHKYWPDkietyggvtvtlhqselfadyeirtfilskAKRSG
|||||||.....  ||  .||.||||.     ||.|..|......|||....||...||. |||.                               . . 
sdyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..............................lredl

SRMVRQFHFTVWPDKGVPQYATaVL----------------------AAGVERTGTYIVIDAMLEQAKkSRTVDIRNYLIALRKDRPHMVQTKEQYLFIH
.|.. |.... ||| |||  .. .|                       ||| |||| .... || . . ...||. ... .||. ||.|||| .|| |..
erlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 344-502 1.4e-33 111.1 In-house 21-181 (297) alignment 
Range on Protein: 344-502
Range on HMM: 21-181/297.0
QQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNgdEDSDYINASFIHGY-DGTPRSFIASQGPLPPTFEDFWRMVWEQNSQSIVMLTNLVELNKTKC
.   . .|....   |||| .|.|.| .|| | ||    ..||||| ..    . ..  .| .||||  | .|||..|.||. . |||...| |  . ||
rgesfssakrnsslrknryrdilatddtrvkllrvi..terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkc

HKYWPDKIET--YGGVTVTLHQSELFADYEIR-TFILSKAKRSGSRMVRQFHFTVWPDKGVPQ
  |||.  .     |  |  . |.   ...      |    || ||.||   |  |||.||| 
apywpsvvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvps
subfamily_Ptp69D_pd Subfamily Ptp69D 597-737 2.5e-33 110.5 In-house 22-159 (307) alignment 
Range on Protein: 597-737
Range on HMM: 22-159/307.0
TGYALEFQRLNSVtshEIPaEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIG
 |.| |...|..    ||.  . .|.|.  |. |||. ||.| .. ||.|.|   .|.|||||| |..... .. ||| | |. .|..|||||... .. 
fglakeyekLear...eid.kstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevt

TIVMLNSLHELDQE-YPEYWPDHGPTKYGHIGVSVLSKQEKG
.||||  | | ...  . |||.   ..||.| | . |.....
livmlsnlteknrkkcakYWpiedevqygdilvklvseekhs
0045450 (Phosphotyrosine protein) phosphatases II 596-735 7.1e-33 110.1 In-house 26-174 (307) alignment 
Range on Protein: 596-735
Range on HMM: 26-174/307.0
MTGYALEFQRLNSVTSHEipAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHAD-EESDYINAVFL--------HAHRGRNAFIATQHPLLETVEDF
.||.. ||..|.||| .     | |... |.| .|||..||......|| |. .. . |.|||||| .         . ..  ..|||||.|| ||||||
ltgllkefekllsvtvfl..lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedF

WRMVTDYDIGTIVMLNSLHELDQE-YPEYWPDHGPT-KYGHIGVSVLSKQE
|||. ......||||..| ||..| ...|||| | .  ||.. | .||...
wrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 328-567 8.9e-33 108.6 In-house 13-276 (307) alignment 
Range on Protein: 328-567
Range on HMM: 13-276/307.0
NGGIRLETEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLErVNGdEDSDYINASFIhGYDGTPRSFIASQGPLPPTFEDFWRMVWEQNSQS
 |  .|  |.... . .     .    || .|||| .. . |..|.|.. ..|   |||| | .. |    |. ||..||||  |  .|| |. ... .|
kgvqalvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvk.fdg.lasdyihanyl.giaikpkkficaqgplentqysfwamaiqekves

IVMLTNLVELNKTKCHKYWPD---KIETYGGVTVTLHQSE-----LFADYE-IRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAV-----------
..|| ...|| | ||..|||    .  ..|  . |.  ..     |  | . |    |     ..|| .... .. |||.||||   .            
vimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydt

------LAAGVERTGTYIVIDAMLEQAKKS-RTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEA
       .||| |.|| . |  . ..  .     |... .  ||..|.. .||. |||..|  .|| 
npvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley
subfamily_PTPRG_pd Subfamily PTPRG 597-734 1.2e-32 107.9 In-house 19-156 (563) alignment 
Range on Protein: 597-734
Range on HMM: 19-156/563.0
TGYALEFQRLNS-VTSHEIPAEEksvGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEES-DYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYD
.|.. ||. |.| ..|....||     ..|.| .||| ..|.| .. || |..    ... ||||| ... ..  .||||||.|| .|..|||||. .  
igfseefealqsetiskdldaeh...sqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqn

IGTIVMLNSLHEL-DQEYPEYWPDHGPTKYGHIGVSVLSKQ
  .|||.  | |   .. . |||  .. .||.. |   ...
vaiivmitnlvergrrkcdvYWPkdesetygalqvtlieee
0046846 (Phosphotyrosine protein) phosphatases II 378-566 1.7e-32 108.0 In-house 6-171 (176) alignment 
Range on Protein: 378-566
Range on HMM: 6-171/176.0
VNGDEDSDYINASFIHGYDgtprsFIASQGPLPPTFEDFWRMVWEQNSQSIVMLTNLVELNKTKCHKYWPDkIETYGGvtvtlhqselfadyeirtfils
   |.|.|||||..| |.      .|| ||||| |..||..|..|.. . .|.||..|||.. ||. |||. .|..|                       
lgldldldyinanlilgsr.....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe.leklgi......................

kakrsgsrmvrQFHFTVWPDKGVPQYaTAVL--------------------AAGVERTGTYIVIDAMLEqakkSRTVDIRNYLIALRKDRP-HMVQTKEQ
           |.... ||| |||.. ...|                     ||. ||||..... .      .. ... . |  .|. || ..||| ||
...........qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpeQ

YLFIHSAVLE
| |.. ..|.
yrflyefell
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 338-566 4.2e-32 106.0 In-house 38-281 (290) alignment 
Range on Protein: 338-566
Range on HMM: 38-281/290.0
KKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLErvNGdEDSDYINASFIHGydgTPRSFIASQGPLPPTFEDFWRMVWEQNSQSIVMLTNLVEL
| .  .|..  .   | .. .|||| ..|  | .||.|.  .|  | ||. | ...|   .   || .||.|  |  |.|||| ...   |||| .|.| 
kpylpvqylerkifdkntefkknrykdvvcndktrvilk..dG.ydGdyvhanyvkG...lkamfiltqGalkdtvidiwrmvlqekvaaivmlcelied

NKTKCHKYWPDK---IETYGGVTVTLHQSELFAD-YEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVL-----------------AAGVERTG
 |.||..|.|.|   . |.| .||.  ...   .    .|. . . .   . ... ..   |||| |.. . |.|                 .||. |||
GkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrkasGpvvvhcsaGiGrtG

TYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLE
|.. |.. |.   . . .|. .   |||. |   ||   ||| .  ..|.
tfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_PTPRK_pd Subfamily PTPRK 621-734 4.9e-32 106.0 In-house 37-150 (314) alignment 
Range on Protein: 621-734
Range on HMM: 37-150/314.0
VGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHELD-QEYPEYWPDHG
.  . .| .|||. ||.| . .||.|.  . | .|||||| .. ...  .|||.||.|| |||.||||.| |..  .||||. | |    .  .|||...
aakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedt

PTkYGHIGVSVLSKQ
 . ||.| | ... .
ev.ygdikvelvete
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 596-736 5.3e-32 106.1 In-house 22-158 (319) alignment 
Range on Protein: 596-736
Range on HMM: 22-158/319.0
MTGYALEFQRLNSVTSHeipaeEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDI
.|. . ||. |.  ..      . .  ....| .|||...|.| . .||.| . .  |.|||||| |. ... |..||||| || .|.||||||| ....
etllekefkllkeavnd.....tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeees

GTIVMLNSLHE-LDQEYPEYWPDHGPTKYGHIGVSVLSKQEK
 ..|||. | | |. .. .|||.. ...||.. | .....|.
sivvmltklveklkvklkkywpeenfeeyGrlivtleeeeel
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 596-735 7.2e-32 105.8 In-house 22-158 (325) alignment 
Range on Protein: 596-735
Range on HMM: 22-158/325.0
MTGYALEFQRLNSVTSHeipaeEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDI
  |.| ||. | |. .       | |   |.|  |||| ...||.  ||.|   . | .|||||| .|. ..... |.|.| || .|..|.||.| |.  
qdgfahefgllpsddgi.....akkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrc

GTIVMLNSLHELDQEYPEYWPDH--GPTKYGHIGVSVLSKQE
  .|.|| | . ...   |||..     ..| . |.. . .|
svvvvlneldlgkdrcavywpkemgksktfGglevklrtiee
subfamily_PTPRB_pd Subfamily PTPRB 574-736 1.2e-31 104.8 In-house 6-162 (293) alignment 
Range on Protein: 574-736
Range on HMM: 6-162/293.0
EIQSENFNQTTQKLASVNrKfqmTGYALEFQRLNSVTSHEipaeEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFI
.|. |.|..  .|... . .   .... |...|..| ...    .... |...|  |||...|.. .  || |.. . ...|||||| ... .. .. ||
piklekfeehvkkmkads.d...lrfseeyeelkavgkdq....avkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefi

ATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHELDQE-YPEYWPDH-GPTKYGHIGVSVLSKQEK
||| || |||.|||||| .    .||||  | |  ..   ||||..  |. ||.| |......|.
atqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeel
subfamily_PTPRA_pd Subfamily PTPRA 606-733 1.2e-31 104.8 In-house 38-165 (330) alignment 
Range on Protein: 606-733
Range on HMM: 38-165/330.0
LNSVTSHEIPAEEKSVgEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLH
.|.. . .| |  .   .. .| .|||. .|.  .  ||.| . .  |||||||| |.. .. .. |||.| |. |||||||||. ...  |||||  |.
fnalPagpiqatlela.skeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelk

ELDQEY-PEYWPDHGPTKYGHIGVSVLSK
| ..|    ||||.|   ||.| |.|  .
erkeekcaqywPdeGlvtyGnirvevede
Y_phosphatase Protein-tyrosine phosphatase 627-731 3.2e-31 103.9 Pfam-A 1-106 (235) alignment 
Range on Protein: 627-731
Range on HMM: 1-106/235.0
NLHKNRFSDIIALNSCRVMLhkEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHEL-DQEYPEYWP--DHGPTKY
|..|||..||.. .. || |  .. ...|||||| ... ..  ..|||||.|| .|.|||||||..... .||||.|| |  ......|||  ......|
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GHIGVSVL
|.| | . 
gdikvelk
Y_phosphatase Protein-tyrosine phosphatase 627-731 3.2e-31 103.9 In-house 1-106 (235) alignment 
Range on Protein: 627-731
Range on HMM: 1-106/235.0
NLHKNRFSDIIALNSCRVMLhkEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHEL-DQEYPEYWP--DHGPTKY
|..|||..||.. .. || |  .. ...|||||| ... ..  ..|||||.|| .|.|||||||..... .||||.|| |  ......|||  ......|
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GHIGVSVL
|.| | . 
gdikvelk
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 510-576 4.8e-31 103.1 In-house 232-298 (298) alignment 
Range on Protein: 510-576
Range on HMM: 232-298/298.0
AGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEALTCGNTEIQ
|||.|.||.|.||..||..||...||.......|||.||..|||.||| ||..||||||...|.||.
aGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndeie
subfamily_PTPN12_pd Subfamily PTPN12 597-734 5.5e-31 102.5 In-house 8-150 (290) alignment 
Range on Protein: 597-734
Range on HMM: 8-150/290.0
TGYALEFQRLNSVTSHEIPAE--EKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYD
  .| |||.| .....    .  ....||...| .|||. ||.  .  ||.|.|.. .|.|||||| |..   |. ..||.| || .|..|||||. ...
eefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiwekn

IGTIVMLNSLHELDQEY-PEYWPDHGPTK--YGHIGVSVLSKQ
.  .||.  . ||..     |||..| ..  .|.. |.. ...
veivvmaCrevelgkkkCerYWpeegeeelefgefevtleeek
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 621-733 6.4e-31 102.4 In-house 43-155 (315) alignment 
Range on Protein: 621-733
Range on HMM: 43-155/315.0
VGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHELDQEYPE-YWPDHg
|  . .| .|||. .||| .  || |     |..|||.|| |.  .  .. .||.| |. ..|.||||.| ..|||.||||..| | ...  | ||||. 
vakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.

PTKYGHIGVSVLSK
   ||.| |.  |.
kviyGkitvtrkse
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 356-566 6.6e-31 102.3 In-house 33-257 (267) alignment 
Range on Protein: 356-566
Range on HMM: 33-257/267.0
NKNKNRYANIVAYDHSRVVLERVNGDedsdYINASFIHGYDgTPRSFIASQGPLPPTFEDFWRMVWEQNSQSIVMLTNLVELNktkCHKYWPDK---IET
|...||. . . ||..||.|   . .    |||||...||  | . ||. |.||  |  ||. .. .|.   ||.||.  . |    ...|| |    . 
nqernrlddnlpyddtrvilrtkeee....yinasyvegyk.tknafivtqdplkntitdfltvihdqkvpvivlltkvftdn...irlfwPPkmgqakk

YGGVTVTLHQSELFADYEIRTFILsKAKRSGSRMVRQFHFTVWPDKG-----------V----------PQYaTAVLAAGVERTGTYIVIDAMLEQAKKS
|  .||     .   ||.| |. | | |   .. |  ...  |  .            .          .       ..|| |.||..|||..||.||. 
yqdltvehslekeendyqiitlel.kfknesahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPl.vvacsdGvGrsGtflvidsqlerakte

RTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLE
 ..|| ..|  .|. |. .|.|||.|..||  . |
gvsdifdflrkirsqriglvdtkeryiyihellae
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 350-495 9.2e-31 101.8 In-house 27-172 (283) alignment 
Range on Protein: 350-495
Range on HMM: 27-172/283.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGdedsDYINASFIH--GYDGTPRSFIASQGPLPPTFEDFWRMVWEQNSQSIVMLTNLVELNKTKCHKYWP
 |    ||.|||. .||..|  || |.  .     |||||.||     .   . .|..|.||  |  |||.||....  .|||||.| | .. || .|||
iasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWP

DK-IETYGGVTVTLHQSELFADYEIRTFILSKAKRSGSRMV-RQFHFTVW
 .  | ||  ||||..      . |. ..| .   . | ..   . .  |
krGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW
subfamily_ptpA1_pd Subfamily ptpA1 353-503 1.7e-30 101.1 In-house 44-204 (418) alignment 
Range on Protein: 353-503
Range on HMM: 44-204/418.0
KPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGydGTPRSFIASQGPLPPTFEDFWRMVWEQNSQSIVMLTNLVELNKTKCHKYWPDKIET
|  | .||||.||.  .|.|| |....  | |||||| .| |    |. ||..||||| |  ||||||||.  . ||||.   |  . || .|||..|  
kkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg..aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigg

-----YG-------GVTVTLHQSELFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQY
     ||         .| | .     . || |  .  .    .| . |...  |||. .|..
eqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdh
0043147 (Phosphotyrosine protein) phosphatases II 380-561 1.9e-30 101.3 In-house 1-154 (172) alignment 
Range on Protein: 380-561
Range on HMM: 1-154/172.0
GDEDSDYINASFIHGYDGTPRsFIASQGPLPPTFEDFWRMVWEQNSQSIVMLTNLvelnktkchkywpdkietyggvtvtlhqselfadyeirtfilSKA
|||.|||||||....|  ..| ||| ||||. |..|||||..|.. . ||.||.|                                           . 
gdegsdyinasyldlyyipdr.fiatqgplrntladfwrmlkelgithivnltel..........................................lyd

KRSGSRMVRQFHFTVWPDKGVPqYATAVLA----------------------AGVERTGTYIVIDAMLeqakksRTVDIRNYLIALRKDRPHMVQTKEQY
.   .|.. |.... ||| |||  .  .|                       ||| |||| .... ||      . ... . .  .|. ||..||...||
pellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqy

LFIH
 |..
rfly
0040439 (Phosphotyrosine protein) phosphatases II 619-736 1.9e-30 101.7 In-house 3-121 (249) alignment 
Range on Protein: 619-736
Range on HMM: 3-121/249.0
KSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHEL-DQEYPEYWPD
.||.. | |..|||..||......|| |.     . |||||| ...  .  ..|||||.|| |||||||||. ...|..||||.|| ||  . . .|||.
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

HGPTKYGHIGVSVLSKQEK
 |...||.. | .|| ..|
ggsleygdftvtllsvevk
0045098 (Phosphotyrosine protein) phosphatases II 617-734 5e-30 100.2 In-house 23-129 (278) alignment 
Range on Protein: 617-734
Range on HMM: 23-129/278.0
EEKSVGEEPQNLHKNRFSDIIALNSCRVMlhkehadeesDYINAVFLHAHrgRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHEL-DQEYPEYW
 | ...  . ||.|||..||......||           ||||| ... .  ...|||||.|| .||.|||||. ...| .||||..|.||  . ...||
seitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqyw

PDHGPTKYGHIGVSVLSKQ
|..|.  ||.. | .|| .
peggsltygdftvtllsee
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 355-566 9.2e-30 98.3 In-house 54-287 (305) alignment 
Range on Protein: 355-566
Range on HMM: 54-287/305.0
ANKNKNRYANIVAYDHSRVVLERVNgdeDSDYINASFIHGYDGTPRSFIASQGPLPPTFEDFWRMVWEQNSQSIVMLTNLVELNKTKCHKYWP----DKI
 .. ||||... . |.| | |.. .    |||| | ..       . ||..||||  | ..|| || ... . |||| . ||| | || .|||    .| 
iaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekl

ETYGGVTVTLH--QSELFADYEIRTFILSKAKRSGSRM-VRQFHFTVWPDKGVPQYATAV-----------------LAAGVERTGTYIVIDAMLEQAKK
|  .|. |        .  | ||.  .|  .   . .| ||....| |||.|||    .                   .||. |||| . |. .||.  .
elksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgskvpivvhcsagigrtgtivaieyilekiae

SR-TVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLE
 .    . . . ||| .| . .|.  ||||||  .|.
nkpcppmpelvkalrdqrafsiqndvqylfihrvmln
0042113 (Phosphotyrosine protein) phosphatases II 620-735 1.7e-29 98.4 In-house 2-118 (245) alignment 
Range on Protein: 620-735
Range on HMM: 2-118/245.0
SVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHELDQE-YPEYWPDH
||.. | | .|||.|||......|| |  .  |. |||||| . . .|  . |||||.|| |||||||||. ...| |||||....||... ...|||..
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

GPTKYGHIGVSVLSKQE
....||.. | .|| . 
esltygdftvtllseeh
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 619-735 2.7e-29 97.2 In-house 43-157 (297) alignment 
Range on Protein: 619-735
Range on HMM: 43-157/297.0
KSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGrnAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHELDQEYPEYWPDH
. | |.  |..|.|...|.  .| ||.|.    | .|||.|| |... .    .|.|| |  .||.|||.|| |... |||||| ..| |..   ||.|.
qtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdk

GPTKYGHIGVSVLSKQE
| |..|.. | .|| .|
gvttfGdvsvvllsvse
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 592-735 4e-29 96.6 In-house 10-151 (281) alignment 
Range on Protein: 592-735
Range on HMM: 10-151/281.0
RKFQMTGYALEFQRLNSVTSHEiPAeekSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVT
.. . .|.. |.. |...  .. .|   .  ....| .|||.|.|.| .  || ..........||||| |. . .| ...|||| |. .....||.|| 
sqndnaGfieeyeklaaigvdn.ta...taskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvw

DYDIGTIVMLNSLHELDQ-EYPEYWPDHG-PTKYGHIGVSVLSKQE
.... .|||.    | ..     ||||.   .|||.. |. ....|
eqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeee
0049260 (Phosphotyrosine protein) phosphatases II 399-561 6.5e-29 96.0 In-house 8-143 (152) alignment 
Range on Protein: 399-561
Range on HMM: 8-143/152.0
PRSFIASQGPLPPTFEDFWRMVWEQNSQSIVMLTNLVELNKTKCHKYWpdkietyggvtvtlhqselfadyeirtfilskakrsgsrmvrQFHFTVWPDK
|. ||| |||.| |..|||||..|.. . |||||.|.||.| ||..|.                                          |.... ||| 
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................................qylhlpwpDh

GVPQYATAVLA---------------------AGVERTGTYIVIDAMLeqakksRTVDIRNYLIALRKDRPHMVQTKEQYLFIH
|||. .  .|                      ||| ||||..... ||      . |.. ...  .|. ||..|....|. |..
gvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_PTPN9_pd Subfamily PTPN9 620-737 3.4e-28 93.5 In-house 35-155 (297) alignment 
Range on Protein: 620-737
Range on HMM: 35-155/297.0
SVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHELDQE-YPEYWP--
 . . . ||.|||..|.. ... ||.| |.. ||.|||||| |.  .. ..|||||| || .||.|||||| . .. .|||   . |  .    .|||  
lasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWple

DHGPTKYGHIGVSVLSKQEKG
..  ...|.. ||... .|. 
eessaefgdlsvsnveveeee
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 578-735 3.5e-28 93.8 In-house 14-164 (319) alignment 
Range on Protein: 578-735
Range on HMM: 14-164/319.0
ENFNQTTQKLaSVNRKF--QMTGYALEFQRLNSvtsHEIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIAT
..|.   |.| |....|  ..| .  ||.|.       ..  ...  . .||  |||. .|.| .  .| |..    | |||||| |.  .. .. .||.
pdfpayyqql.snksdfdddltklevefrrack...lgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaa

QHPLLETVEDFWRMVTDYDIGTIVMLNslhelDQEYPEYWPDHGPTKYGHIGVSVLSKQE
| || .|..|||||. .|.. |||.|       .   .||| ..  |...  |.| | .|
qGPldntladfWrmiweyncstivllt.....kdkcsqywplkivikeerfkvkvdsvee
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 613-737 5e-28 92.8 In-house 30-157 (315) alignment 
Range on Protein: 613-737
Range on HMM: 30-157/315.0
EIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHELDQ-EY
. .. .. |. |..| .|||. .|. |.| ||.|     . .|||||| ....    .|.||.| ||  .|.|||||| .... ||||.. ..| |. . 
dPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikc

PEYWPD--HGPTKYGHIGVSVLSKQEKG
  ||||     ...| | |..|| .  .
rqywPdrkadsvefGsikvellsleadt
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 591-735 6.7e-28 92.5 In-house 14-152 (287) alignment 
Range on Protein: 591-735
Range on HMM: 14-152/287.0
NRKFQMTGYALEFQRLNSVTSHEipaEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHkehaDEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMV
...   .|.   |. |..|| .|   .|  ..  .|| .|||...|.  .  ||.|.    .|. |||||||. ... ..|||... |. .|. .||...
ghakgnegfknqftvleqvtqre...devthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkli

TDYDIGTIVMLNSLHELDQEY-PEYWPDHGPTKYGHIGVSVLSKQE
 |  . .||||  ..| |.|   .|||..  . .|.  ...|... 
ddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneev
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 509-606 1.4e-27 91.6 In-house 221-318 (318) alignment 
Range on Protein: 509-606
Range on HMM: 221-318/318.0
AAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEALTCGNTEIQSENFNQTTQKLASVNRKFQMTGYALEFQRL
.||| |||..|..|..||..|.  .||. ..   ||. |. ||||..|| ||. ..||||..|.||........  ..|  .. .  .|   .|||||
saGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelreqdpesgttemdaefqrl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 616-736 3.9e-27 90.2 In-house 35-158 (305) alignment 
Range on Protein: 616-736
Range on HMM: 35-158/305.0
AEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHELDQEY-PEY
 |   ||.. .| .|||...|. |.  |..| ... ...|||||| ...........|..| || .||.||||.. .. . |||||  | | ...    |
eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqY

WPDHGPT--KYGHIGVSVLSKQEK
||.      ..|.. | . |... 
Wpesktekkefgefsvelksekta
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 614-735 5.2e-27 90.1 In-house 12-128 (284) alignment 
Range on Protein: 614-735
Range on HMM: 12-128/284.0
IPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNslhelDQEYPE
... ...  . .||  |||. .|.| .  .| |..    | |||||| |.  .. .. .|||| || .|..|||||. .|.. |||.|      ..   .
vngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.....kdkcsq

YWPDHGPTKYGHIGVSVLSKQE
||| ..  |...  |.| | .|
ywplkivikeerfkvkvdsvee
subfamily_PTPN6_pd Subfamily PTPN6 573-735 1.4e-26 88.2 In-house 2-165 (306) alignment 
Range on Protein: 573-735
Range on HMM: 2-165/306.0
TEIQSENFNQTTQKLASVNRKFQMTGYALEFQRLNSVTSHEipAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHkEHADEESDYINAVFLH--AHRGRN
|.. ... .|  ..|   . ... .|.  ||..|.   ...    ... |. |.| .|||.  |.  .  ||.|. |.   .|||||| ...  ..  ..
tsllakeieqrvselekeeeslekagfeeefeelqqeeakk..llsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdk

AFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHELDQ-EYPEYWPDHGP-TKYGHIGVSVLSKQE
..||||  | .||.|||||| . .   |||.    |  .     ||||.   ..||.| |. .|...
syiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseks
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 510-604 1.5e-26 88.3 In-house 225-319 (319) alignment 
Range on Protein: 510-604
Range on HMM: 225-319/319.0
AGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEALTCGNTEIQSENFNQTTQKLASVNRKFQMTGYALEFQ
||| ||||.||.|||||. |.  ..|. ..   ||  |. |||..||| ||. |.|||...|.|||. .....  ..||. . .  .|| . |||
aGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqlaekvadtgetglerefq
subfamily_CG7180_pd Subfamily CG7180 595-733 2.3e-26 87.1 In-house 11-148 (296) alignment 
Range on Protein: 595-733
Range on HMM: 11-148/296.0
QMTGYALEFQRLNSVTSHeIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYD
..  . .|.. .  .|.. .  ..   | . .|. |||  ...  .  ||.|.| . .|.|||||||.  ..   ...| |. |  |||..|||.| | .
krrkfrveyklelkltpr.leigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydee

IGTIVMLNSLHELDQEYPEYWPDHGPTKYGHIGVSVLSK
| ..|.|    .  . ||.||| .. ..||.| | ....
isavvvLtktfdfakmypsywpnkskeqygeifveivee
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 590-734 4.2e-26 86.5 In-house 13-156 (290) alignment 
Range on Protein: 590-734
Range on HMM: 13-156/290.0
VNRKFQMTGYALEFQRLNSVTSHeipaEEKSVGEEPQNLHKNRFSDIIALNSCRVMLH--KEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFW
 ... ...|.  .|..|.|  |.    ..  ||  ..| ..|||..|.  .  |..|.   .| | . .||||.... .. ....|||| |. .|. |||
nghakgnegfrnqfkmldsgese....htvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFW

RMVTDYDIGTIVMLNSLHELDQE-YPEYWPDHGPTKYGHIGVSVLSKQ
... . ..  |||| .  | ...    ||||.. ..||.. . .|. .
kliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllnee
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 619-736 4.5e-26 86.0 In-house 35-155 (515) alignment 
Range on Protein: 619-736
Range on HMM: 35-155/515.0
KSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHELDQE-YPEYWPD
..| .|  | .|||. .|. ..| || |   . . .|||.|| ....    .|.||.| |.  .|.||||.| .... ||.|.. |.| |.    .||||
qtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPd

--HGPTKYGHIGVSVLSKQEK
      |.|.| |...| .  
kpgdsvkfGsikvelvsleac
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 509-577 5.7e-26 86.2 In-house 183-245 (250) alignment 
Range on Protein: 509-577
Range on HMM: 183-245/250.0
AAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEALTCgnteiqS
.||| |.|..|.|||.||..||...||.......|||||||.|...||| |.....|.||..      .
saGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds......v
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 333-573 7.5e-26 85.8 In-house 21-276 (288) alignment 
Range on Protein: 333-573
Range on HMM: 21-276/288.0
LETEYKKFNNGQQFPwEAARKPANKNKNRYANIVAYDHSRVVLErvngdEDSDYINASFIHGYDGTPRSFIASQGPLPPTFEDFWRMVWEQNSQSIVMLT
|. ||.   |. .    .    ||  ..|| |.   | .|| |.     .|.|.  |. .      .| .| .| ||  | | .|.|. |.. . ||||.
lkkeyrdspneasid.iidsfianptrdryenlprcditrvkls.....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlc

NLVELNKTKCHKYWPDKIETY---GGVTVTLHQSELFADYEIRTFILSKAKRSGSRM-VRQFHFTVWPDKGVPQY-ATAV----------------LAAG
.|.|. | |  .|.| |.      | .     ..    |  ..  .|   |    .. |.. |.  |.|.|||.   . .                  ||
ellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqkPivvhssaG

VERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEALTCGNT
| |||| |.|  .||... .  . ||. |  ||..| . .||. |||..|  ||| |     
vGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelllkky
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 331-566 9e-26 85.3 In-house 24-285 (305) alignment 
Range on Protein: 331-566
Range on HMM: 24-285/305.0
IRLET-EYKKFNNGQQFpwEAARKPANKNKNRYANIVAYDHSRVVLervNGDEDSDYINASFIHGyDGTPRSFIASQGPLPPTFEDFWRMVWEQNSQSIV
.| |    |.||. ...  .| ..  ...|||| ..   |. || |   .|    .|| | ..      |. || .| ||  |  ||| | .... ..| 
lraefvamkrfndfekm..kafkeaqeagknrykdvgcldnnrvkl...egpwpheyihanyvst.ptnpkrfictqaplektcadfwymclqdkveaif

MLTNLVELNKTKCHKYWPDKI-------ETYGGVTVTLHQSELF-----ADYEI-RTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVL--------
|| ||.|    ||..|.. |        |    ..| .  |. .     |. .. .| .. .   . .| | ..|.  |||.|||   .|.|        
mlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarp

---------AAGVERTGTYIVIDAMLEQAKKSRTVDIRN-YLIALRKDRPHMVQTKEQYLFIHSAVLE
         .||. |||. .... .|.|    . ..  .  |  .|..|   .|| .||||.|  .|.
skgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln
0044763 (Phosphotyrosine protein) phosphatases II 368-565 9e-26 86.0 In-house 2-168 (178) alignment 
Range on Protein: 368-565
Range on HMM: 2-168/178.0
YDHSRVVLERVNGDEDSDYINASFIHGYdgtprSFIASQGPlpptfEDFWRMVWEQNSQSIVMLTNLVELNKTKCHKYWPDKIEtyggvtvtlhqselfa
.|..||.|. . | | |||||||.| ..      ...|..|     .|......|.. ..||.||. .||.. ||..|||.. .                
ldrtrvllsnleglersdyinaseilpg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

dyeirtfilskakrsgsrmvRQFHFTVWPDKGVPQYATAVL---------------------AAGVERTGTYIVIDAMLEQakksrTVDIRNYLIALRKD
                     |.... .|| |||.    .|                      ||| |.|| .... |...      ... . .  .|. 
....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrer

RPhMVQTKEQYLFIHSAVL
|| .|.. .|. ...   |
Rp.ivpnpgqlrqLyefel
0037934 (Phosphotyrosine protein) phosphatases II 622-736 1.5e-25 85.6 In-house 5-113 (243) alignment 
Range on Protein: 622-736
Range on HMM: 5-113/243.0
GEEPQNLHKNRFSDIIALNSCRVMLhkehadEESDYINAVFLHAHrGRnaFIATQHPLLETVED----FWRMVTDYDIGTIVMLNSLHEL-DQEYPEYWP
.  |.||.|||.|||....  || |      | |||||| .     .|  .||||.|| |||||    ||||. ...|..||||..| ||  . ...|||
allpenlsknrysdilpydhsrvkl......egsdyinanliyvt.pr..liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

dhGPTKYGHIGVSVLSKQEK
  |.. ||.. | .|| ...
..gevtygdftvtllseehl
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 597-731 3.3e-25 83.5 In-house 6-137 (283) alignment 
Range on Protein: 597-731
Range on HMM: 6-137/283.0
TGYALEFQRLNSVTsheIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHAdeesDYINAVFLH---AHRGRNAFIATQHPLLETVEDFWRMVTDY
... | ...|. ..   .|  .  .    .| .|||. .|.. .  || |. |      |||||||.     ..  . .|..| || .|| |||.|| | 
nnnklfrevlkrls...vpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfde

DIGTIVMLNSLHEL-DQEYPEYWPDHGPTKYGHIGVSVL
.| .||||  | |  ...   ||| .|  .||   |.. 
kitaivmltklqedlrikCsqyWPkrGsedyGeftvtlr
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 352-566 5.6e-25 82.5 In-house 33-267 (281) alignment 
Range on Protein: 352-566
Range on HMM: 33-267/281.0
RKPANKNKNRYANIVAYDHSRVVLER-VNGDEDSDYINASFIHGyDGTPRSFIASQGPLPPTFEDFWRMVWEQNSQSIVMLTNLVELNKTKCHKYWPDKI
 .| |..||||.|| . | ||| |.  .   . .||| | .|.      | .| .|||   |  |||||.|..|. .|||| ...| |. || .|.| . 
nqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirs.pflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprna

ET---YGGVTVTLHQSELfaDYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVL-----------------AAGVERTGTYIVIDAMLEQAKK
     .  ..|.  .| .  .  . |  |  .    .|.. .. .  |||  ||. .  .|                 .||| |.|| . ..  |.  . 
hcclqfdklsvsyedstv..nkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirarstppvihcsagvgrsgtlmaveialqsihs

SRTV-DIRNYLIALRK-DRPHMVQTKEQYLFIHSAVLE
  |. ||.. .  ||   |   ||| .||..|   .|.
hftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 509-587 8.6e-25 82.5 In-house 224-302 (305) alignment 
Range on Protein: 509-587
Range on HMM: 224-302/305.0
AAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEALTCGNTEIQSENFNQTTQKL
 ||| |||..|..| .||..||  .||. ..| .||. |. ||||..|| |.| |. | .|||.|.|  .|..   .||
sagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvnkl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 509-567 2.3e-24 80.9 In-house 181-239 (239) alignment 
Range on Protein: 509-567
Range on HMM: 181-239/239.0
AAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEA
.||| |||...|||||| |||| .|||| ||. |.|.|||||||| |||.||| |||||
sagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavlea
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 356-574 6.5e-24 79.2 In-house 43-282 (312) alignment 
Range on Protein: 356-574
Range on HMM: 43-282/312.0
NKNKNRYANIVAYDHSRVVLervNGDEDsDYINASFIHGYdGTPRSFIASQGPLPPTFEDFWRMVWEQNSQSIVMLTNLVELNKTKCHKYWPDKIetyGG
 |. ||| ||  .|  |  |    |||.  || | |..     |  |...||||  |   ||...    | ||..|. .||    || ||  | .   | 
fkdlnrypniqcwdrgrftl...agden.fyihanfvkic.tkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdiv...gf

VTVTLHQ--SELFADYEIRT--------F---ILSKAKRSGSRmVRQFHFTVWPDKGVPQYAT-----------------AVLAAGVERTGTYIVIDAML
| .  |.  .|  .. ||              .. ||    |. . .. .. |||.|.|.                    |  .||| |||| ..|..|.
vdledhrvyteycteieiggkskdkithrvlkvvvkatgqesk.lnhyqwaswpdhgmpdscdtalrllsavkkdkkpviahcsagvgrtgtlaliesmi

EQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEALTCGNTE
   .. |  .... .. |||||   |..  ||..   .||| | .    
aalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskgly
0051082 (Phosphotyrosine protein) phosphatases II 383-565 7.2e-24 79.5 In-house 2-150 (151) alignment 
Range on Protein: 383-565
Range on HMM: 2-150/151.0
DSDYINASFIHGYdgtprsFIASQGPLPptfeDFWRMVWEQNSQSIVMLTNLVELNktKCHKYWPDKIetyggvtvtlhqselfadyeirtfilskakrs
 |||||.|.. |.      ...|.|||.    ||.....|.. ..||.|....| .  .|..|.|.                                  
lsdyinfsyvtgg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg................................

gsRMVRQFHFTVWPDKGVPQYATAVLA------------------AGVERTGTYIVIDAMLEQakksrtVDIRNYLIALRKDRPHMVQTKEQYLFIHSAV
  . |...... ||| |.|..  |||.                  ||. |||| .... ||..      |..   |  .|. ||..||...|.||.. |.
..ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfal

L
|
l
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 509-566 9.2e-24 78.9 In-house 182-239 (239) alignment 
Range on Protein: 509-566
Range on HMM: 182-239/239.0
AAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLE
.||| |||...|||||| |||| .|||| ||. |.|.|||||||| |||.||| ||||
sagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 613-734 1.1e-23 78.7 In-house 13-142 (274) alignment 
Range on Protein: 613-734
Range on HMM: 13-142/274.0
EIPAEEKSVG-EEPQNLHKNRFSDIIALNSCRVMLHKEHADEE-SDYINAVFLHAHRG-RNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHELDQ
|.|.. .    . . . .|||. .|.  .  ||.|..|....| |.|||| ...  ..  .|..||| || .||.|||||.   ..  ||||  |.| ..
elPlnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeane

-EYPEYWPDHGPT----KYGHIGVSVLSKQ
    .|.||.  .    .||.. . | .. 
qkCavyfPdaedyeiserygdveikvekiv
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 358-461 1.2e-23 78.5 In-house 49-163 (350) alignment 
Range on Protein: 358-461
Range on HMM: 49-163/350.0
NKNRYANIVAYDHSRVVLER--------VNGDEDSDYINASFIHGY----DGTPRS-FIASQGPLPPTFEDFWRMVWEQNSQSIVMLTNLVELNKTKCHK
 |||| ||. |.|||| |..            . .|||||....      .  |   .|| |.||| |..||.... . . . |..||..||||  ||..
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPDKieTYGGVTVTLH
||..   .| ..|| | 
YWqeg..sydditvkla
subfamily_PTPN23_pd Subfamily PTPN23 596-736 2.3e-23 77.4 In-house 14-152 (288) alignment 
Range on Protein: 596-736
Range on HMM: 14-152/288.0
MTGYALEFQRLNSVTSHEipAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHkehaDEESDYINAVFLHAH-RGRNAFIATQHPLLETVEDFWRMVTDYD
 |.   .|. |..   .|  |...|.     . .|||. ||.  .. ||.|.    ... ||||| |..    |   ||||| || .|. |||.|| .  
ktaldkkfkeleqkqdke..arkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqk

IGTIVMLNSLHELDQE-YPEYWPDH--GPTKYGHIGVSVLSKQEK
  .|||| | .||...   .||| .   ..|.|.. |.. |..| 
ssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvret
subfamily_PTPRN_pd Subfamily PTPRN 608-732 3.3e-23 76.9 In-house 37-163 (297) alignment 
Range on Protein: 608-732
Range on HMM: 37-163/297.0
SVTSHEIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRN-AFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHE
.....|   . |.|.....|..||| ..... .  || |..| ..|.|||||| ..  |  |. |.|||| || .|| |||.|| .  .  ||.| .|.|
alcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrlee

LDQEY-PEYWPDHGPTKYGHIGVSVLS
 . .   .||||.|   |.   | ..|
egvkqckrywpdeGsevyhiyevhlvs
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 335-472 4.2e-22 73.1 In-house 31-167 (310) alignment 
Range on Protein: 335-472
Range on HMM: 31-167/310.0
TEYKKFNNGQQ--FPWEAARKpaNKNKNRYANIVAYDHSRVVLErVNGDEDSDYINASFIHGyDGTPRSFIASQGPLPPTFEDFWRMVWEQNSQSIVMLT
 .|.|..  |.  . .|| .|  .  ||||...|  | ||| |. ..     ||| | ...  .    .|| |||||  |  |||||.... ..||..| 
kqyrkldakqdssltyeaykk..ymhknrysdvvcldtsrvklk.idksryedyihanyvkt.nylrstficsqgplqhtiidfwrmifqeraesilllc

NLVELNKTKCHKYWPD--KIETYGGVTVTlHQSELFADYEIR
. .|  . ||  |||     |||| . ||   ||   ..|| 
kvgeegrpkcvgywpslgvtetygcirvt.nlsesseefeic
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 616-709 1.7e-21 71.1 In-house 34-127 (392) alignment 
Range on Protein: 616-709
Range on HMM: 34-127/392.0
AEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHELDQ
. ...|.... ||.|||. .|. ..| ||.|       .|||.|| ....    .|.||.| |   ...|||||| . .. ||.|.. |.| |.
iypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegdk
subfamily_PTPN3_pd Subfamily PTPN3 620-735 4e-21 70.2 In-house 34-151 (280) alignment 
Range on Protein: 620-735
Range on HMM: 34-151/280.0
SVGEEPQNLHKNRFSDIIALNSCRVMLHKEhadeESDYINAVFLHAHR----GRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHELDQ-EYPEY
|.   |.||.|||. ||.. .. ||.|...    |.||||| ..          | .|||| || .|..|||.|| . .. .|||| .| |  .    .|
saarkpenlsknryrdilpydatrvklkes....etdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqy

WPDHGP-TKYGHIGVSVLSKQE
||...  ..||.. | . ...|
WPetedeleygefsvkcekede
subfamily_PTPRK_pd Subfamily PTPRK 510-588 5.2e-21 69.8 In-house 219-297 (314) alignment 
Range on Protein: 510-588
Range on HMM: 219-297/314.0
AGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEALTCGNTEIQSENFNQTTQKLA
||  ||||.|.|| .|. ... ..||. |   .||. .. ||.|.||| ||. ..|||  ||.| |   .|. .  .  
aGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalylesi
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 509-612 1.9e-20 67.5 In-house 217-320 (515) alignment 
Range on Protein: 509-612
Range on HMM: 217-320/515.0
AAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEALTCGNTEIQSENFNQTTQKLASVNRKFQMTGYALEFQRLNS
.||| ||| .| || .. .||..|.||. |..  .|..||..|||.||| ||. |||| |   || |    | .  | | |       .  . ||| |.|
saGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmtkefqtlks

VTSH
..  
lcpd
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 617-732 2e-20 67.9 In-house 10-131 (270) alignment 
Range on Protein: 617-732
Range on HMM: 10-131/270.0
EEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLH-AHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHELDQEY-PEY
.|... |  .. . ||. ||.     ||.|.... |... |||| ... ..  ....||.. ||  |...||||. .    .|||.  |.|  ..    |
sesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerY

WPDHGPT----KYGHIGVSVLS
|| .  .    ..|.| | .||
Wpaepkekvkledgkikvlals
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 483-597 5e-20 66.2 In-house 87-223 (440) alignment 
Range on Protein: 483-597
Range on HMM: 87-223/440.0
GSRMVRQFHFTVWPDKGVPQYATAVL----------------------AAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFI
 || ..|.|.  |||||||..|  ||                      .||. |||  |..|..| .||.|  .|| ... ..|..||.|||| ||| |.
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

HSAVLEALTCGNTEIQSENFNQTTQKLASVNRKFQMT
| ||||.| ||.| |  ..  .  ...   | . . .
heavlegllcgdtliledditerveqiqwpnphtdks
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 612-735 7.2e-20 65.9 In-house 24-147 (287) alignment 
Range on Protein: 612-735
Range on HMM: 24-147/287.0
HEIPAEEKSvGEEPQNLHKNRFSDIIALNSCRVMLHKEhADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVML-NSLHELDQE
.  .|  |.  ||  . .|||..|.. ..  ||.| .| ..  |||||| .. ...  .||||.| |.  || ||||.| .    .....   . |  ..
esstatfka.aeelaavkknryadvlPiddtrvllsae.gelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlk

YPEYWPD-HGPTKYGHIGVSVLSKQE
  .|||. . | . |   | .|... 
cykywPerevPmrvGGysvvlldydi
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 509-580 1e-19 65.8 In-house 225-296 (297) alignment 
Range on Protein: 509-580
Range on HMM: 225-296/297.0
AAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEALTCGNTEIQSENF
 ||| ||| .. || .. .||.  .||| ...  ||..||..||||||| |.. |||||| . .|.||.. |
laGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqasyf
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 356-560 1.1e-19 65.3 In-house 50-273 (301) alignment 
Range on Protein: 356-560
Range on HMM: 50-273/301.0
NKNKNRYANIvAYDHSRVVLERVNGDedSDYINASFIHGYdGTPRSFIASQGPLPPTFEDFWRMVWEQNSQSIVMLTNLVELNKTKCHKYWPDKIET---
.|.|.|| ..   . |  |   |.|      | | .|    | |. |||.||||. | |||| |.   . . ||||.. || ...||..| | ||.    
pkdkhryptv.PckPstavevivdGk..rvPihanwipts.GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekld

YGGVTVTLHQSELFADYEI--RTFIL-SKAKRSGSRMVRQFHFTVWPDKGVPQYATAV-----------------LAAGVERTGTYIVIDAMLEQAKKSR
 |  .......||  . .|  ||. .   ...  .| |  . .. |.|.|||.  . .                  .||. |. ..|  . .  . .  .
igrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigteylareveadp

TVDIRNYLIALRKDRPHMVQTKEQYLFI
|... . |  ||..| . |||..|  ..
tieltealkhlrehrwngvqtnsqlywm
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 603-730 1.9e-19 64.4 In-house 26-147 (439) alignment 
Range on Protein: 603-730
Range on HMM: 26-147/439.0
FQRLNSVTSHeIPAeEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLN
|. .||.      . . |.  .  .  |||. |. |..  ||.|..      | |||| ... .   . .|||| |  ||..||||.| .    ||||| 
fekinstspd.yac.iaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmlt

SLHELDQeypeYWPDHGPTKYGHIGVSV
 | |  .    |||  . . || | | |
nlvesyk....ywpsdaevcygdiavrv
subfamily_egg_pd Subfamily egg 344-448 2.9e-19 63.9 In-house 28-129 (307) alignment 
Range on Protein: 344-448
Range on HMM: 28-129/307.0
QQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPTFEDFWRMVWEQNSQSIVMLTNLVELnkTKCH
.. . . | .  |..| |   .   | ||| ||  .|    |.| |  ..|       || .| ||  | .||||||.... | |||||  .|    .|.
deislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkp.llnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erce

KYWPD
 ||| 
yywpk
subfamily_PTPN1_pd Subfamily PTPN1 616-718 4.6e-19 63.2 In-house 21-120 (290) alignment 
Range on Protein: 616-718
Range on HMM: 21-120/290.0
AEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHAdeesDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHELDQE-YPEY
  . .. ..|.|  .||. |.   . .|..|....     ||||| ...... .  .| || || .||. ||.|| . .  ..|||| . | .|    .|
dfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqy

WPDH
|| .
wPqg
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 616-734 5.5e-19 63.0 In-house 29-150 (301) alignment 
Range on Protein: 616-734
Range on HMM: 29-150/301.0
AEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHA--DEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHEL-DQEYP
 .. .|| . .| . ||| .|  ..  |..|.....    . .|||| .... . ...|||.| |. .|. ||||.. ..   .|||.  |.|   ..  
dksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskce

EYWPDHGPTKYGHIGVSVLSKQ
.|||.   ...    ..|. ..
qywpnseaeseefgpftvtlvn
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 626-733 8.9e-19 62.2 In-house 51-159 (310) alignment 
Range on Protein: 626-733
Range on HMM: 51-159/310.0
QNLHKNRFSDIIALNSCRVMLHKEHADeESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHELDQE-YPEYWPDHGPTK-Y
...||||.||.. |...|| |. ...    ||| | ....   |..|| .| ||  |. |||||. .    .|..|    |  .     |||  | |. |
kymhknrysdvvcldtsrvklkidksr.yedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtety

GHIGVSVLSK
| | |. ||.
gcirvtnlse
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 509-590 9.9e-19 62.3 In-house 218-299 (315) alignment 
Range on Protein: 509-590
Range on HMM: 218-299/315.0
AAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEALTCGNTEIQSENFNQTTQKLASV
.||| |||  | || ...|.|..|.||. |..  ||..||..|||.|.| ||. |||| |   || |   .| .  | | . 
saGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlhts
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 615-718 1e-18 62.2 In-house 21-125 (297) alignment 
Range on Protein: 615-718
Range on HMM: 21-125/297.0
PAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHadEESDYINAVFLH--AHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHELDQ--E
 .|. |.   .  |.|||. ||.| .. || | .     |.||||| ..          .| .| || .||.|||..|.. |...|||.  | |  .   
rgesfssakrnsslrknryrdilatddtrvkllrvi..terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkc

YPeYWPDH
.| |||. 
ap.ywpsv
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 354-522 1.4e-18 61.8 In-house 33-224 (285) alignment 
Range on Protein: 354-522
Range on HMM: 33-224/285.0
PANKNKNRYANIVAYDHSRVVLErvngDEDSDYINASFIHGYDGTPRSFIASQGPLPPTFEDFWRMVWEQNSQSIVMLTNLVELNKTKCHKYWPDKIE--
 || . ||||.. . . .||||.    . | ||| ||...       ..|..||||| |. |||.|.....   ..||  |.|    ||  |.|.|.   
eanpdlnryadvrcieetrvvlk....nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgev

-TYGGVTVTL--HQSELFADYEIRTFILSKAKRSGSRMVRQFH--FTVWPDKGVPQYATAVL--------------------AAGVERTGTYIVID
  .|   .||   . |  |   . .. . ... . |  .   |     |||.  |. |  ..                    .||| || |.. ||
vkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgid
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 509-585 1.6e-18 61.7 In-house 220-296 (315) alignment 
Range on Protein: 509-585
Range on HMM: 220-296/315.0
AAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEALTCGNTEIQSENFNQTTQ
 ||| ||||.| .||.|.||.  . .|. |..  .|. | .|||. ||| ||..|.||.. ||.| |  . . |  .
saGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqryd
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 626-735 1.6e-18 61.8 In-house 2-112 (237) alignment 
Range on Protein: 626-735
Range on HMM: 2-112/237.0
QNLHKNRFSDIIALNSCRVMLHKEHADeeSDYINAVFLHAHRGR-NAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHELDQE-YPEYWPDH-GPTK
.|  |||...|.| . .||.|.   ..  |||||| .|.   |  . .||.| ||  . .|||.|| .     ||||  | | ...   .|||.   |. 
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGHIGVSVLSKQE
|| . ||.  |.|
ygvltvslkkkee
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 509-566 2.5e-18 61.1 In-house 180-237 (237) alignment 
Range on Protein: 509-566
Range on HMM: 180-237/237.0
AAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLE
.||| ||| ..|||||| |||. . ||| ||. .. .|||...|||.||.||| ..||
sagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 509-588 3.9e-18 60.8 In-house 232-311 (319) alignment 
Range on Protein: 509-588
Range on HMM: 232-311/319.0
AAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEALTCGNTEIQSENFNQTTQKLA
.||| |||.|||.|..|.. |. . ||. |..  ||..|...||   || ||.||.||    |....   .|    ..|.
saGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleels
subfamily_PTPRB_pd Subfamily PTPRB 509-570 4.7e-18 60.2 In-house 226-287 (293) alignment 
Range on Protein: 509-570
Range on HMM: 226-287/293.0
AAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEALTC
.||| ||||.| .| .|.. ... .|||   ...||..| ..|||..||.|||..||. |. 
saGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 509-588 7.4e-18 60.0 In-house 196-275 (284) alignment 
Range on Protein: 509-588
Range on HMM: 196-275/284.0
AAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEALTCGNTEIQSENFNQTTQKLA
.||| |||.|||.|..|.. |. . ||. |..  ||..|...||   || ||.||.||    |....   .|    ..|.
sagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleels
subfamily_PTPN14_pd Subfamily PTPN14 610-719 8.3e-18 59.4 In-house 33-143 (300) alignment 
Range on Protein: 610-719
Range on HMM: 33-143/300.0
TSHEIpAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADeESDYINAVFLHAHRG--RNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHEL
. ..    . |... |.| .|||| |..  . .|| |   . . ...||||  ...  |  .  .|..| ||  ||.|||.|| . ..  |||| . .| 
pkkre.dallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeed

DQE-YPEYWPDHG
 .|   .|.|...
gkeksfkyfPkle
0049772 (Phosphotyrosine protein) phosphatases II 586-715 9.6e-18 60.4 In-house 5-163 (314) alignment 
Range on Protein: 586-715
Range on HMM: 5-163/314.0
KLASVNRKFQMTGYALEFQRLNSVTSHEIPAEEKSVGEEPQNLHKNRFSDIIALNsCRVMLHKEHADEeSDYINAVFLHAHrgrNAFIATQHPLLETVED
 |||...  ..  .  ....||...   .|.    |.  . | .|||. ||.  . .||.|.... .  |||||| ... .   ..|||||.|| .||.|
plasfsellihddllklllvlnrrslsvlpeltilvadlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvd

F----------WRMV--TDYDIGTIVM---------------------LNSLHEL-DQEYPEYW
|          ||||   |... .|||                     |..| .. ..  ....
freepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgngneptaadl
subfamily_ptpA1_pd Subfamily ptpA1 614-717 9.9e-18 59.0 In-house 34-137 (418) alignment 
Range on Protein: 614-717
Range on HMM: 34-137/418.0
IPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRnAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHEL-DQEYP
.   | | |.. .|  |||...|. .|  || |.| .  | |||||| ..     .  ||.|| || .|. |||||| .     ||||.   |    .  
vgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk.qfictqgplpntiadfwrmvwenrcriivmlsresencrikcd

EYWPD
 |||.
rywpe
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 611-719 1.2e-17 58.7 In-house 31-154 (350) alignment 
Range on Protein: 611-719
Range on HMM: 31-154/350.0
SHEIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLH--------KEHADEESDYINAVFLHAH----RGRNAF--IATQHPLLETVEDFWRMVTDYDIG
..| | ..  . |  .   |||...|.  .  || |.        |.|. . .||||| .|.      .    |  |||| || .||.||.....  .. 
dsespsnDvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvk

TIVMLNSLHELDQE-YPEYWPDHG
 |..|.|. ||. | . .||.. .
vilsltsdvelnlekcyrYWqegs
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 509-592 2e-17 58.3 In-house 229-312 (325) alignment 
Range on Protein: 509-592
Range on HMM: 229-312/325.0
AAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEALTCGNTEIQSENFNQTTQKLASVNR
.||| |||..| . ..|..  .   ||| ...  |||||| ||.| .|| .|. |. ||. .|||..   .|.     |   | 
saGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklsslqernp
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 602-729 2.4e-17 57.8 In-house 11-131 (267) alignment 
Range on Protein: 602-729
Range on HMM: 11-131/267.0
EFQRLNSVTSHEIPAeEKSVGEEpqNLHKNRFSDIIALNSCRVMLHKEHADeesdYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVML
||. .. ... .     .|..|.  |  .||. | .  .  ||.| ..  .    |||| ...... .||||.|| ||  |. ||. ...|... .||.|
efelikkisdtssti.sqsiaek..nqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivll

NSLHEldQEYPEYWPDH-G-PTKYGHIGVS
    .  .. . .|| . |   ||  . | 
tkvft..dnirlfwPPkmgqakkyqdltve
subfamily_PTPN13_pd Subfamily PTPN13 596-718 4.5e-17 57.2 In-house 10-126 (273) alignment 
Range on Protein: 596-718
Range on HMM: 10-126/273.0
MTGYALEFQRLNSVTsheiPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKEHAdeesdYINAVFLHAHRGRNAF--IATQHPLLETVEDFWRMVTDY
    | ||. |. .     | .. .||.. .| .|||. ...  .  || | .| .     |||| ..... | . .  ||.| || |||.|||.|| . 
qqqPaeefkelrelk....pldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweq

DIGTIVMLNSLHELDQ-EYPEYWPDH
.   |.|. .  | ..     |||..
kaeviamvtlekekgkvkchrywPes
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 311-396 5.1e-17 56.3 In-house 4-87 (440) alignment 
Range on Protein: 311-396
Range on HMM: 4-87/440.0
KPIPIALFPEYVAKMQANggIRLETEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYD
.|| .| | .|| . .       | |.  . .| . | . |  | || |||| ||.|||||||.|| |.|  ||||||||.| | .
rpiivadfadyvqnnrrs..rafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingie
0041856 (Phosphotyrosine protein) phosphatases II 627-720 8.1e-17 56.8 In-house 1-92 (182) alignment 
Range on Protein: 627-720
Range on HMM: 1-92/182.0
NLHKNRFSDIIALNSCRvmlhkehadeESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNslheldqeYPEYWP----------
||.|||.|||.  .  |           .||||| ..   .  . |||||.|||.||.||.||. ...|.|||.|.         . |||          
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt........eelywpellerlgiqy

------DHGP
      |||.
lylpwpDhgv
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 627-729 1e-16 55.8 In-house 8-111 (239) alignment 
Range on Protein: 627-729
Range on HMM: 8-111/239.0
NLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGR-NAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHELDQ-EYPEYWPDHGpTKYG
|  |||...|.. .  ||.| |   |  |||||| .|. . |  .|.||||  .  .  |||||. .     ||||  | |  . .  .||||   .|| 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst.skyc

HIGVS
 . |.
nlrvt
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 627-729 1.1e-16 55.8 In-house 7-110 (239) alignment 
Range on Protein: 627-729
Range on HMM: 7-110/239.0
NLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGR-NAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHELDQ-EYPEYWPDHGpTKYG
|  |||...|.. .  ||.| |   |  |||||| .|. . |  .|.||||  .  .  |||||. .     ||||  | |  . .  .||||   .|| 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst.skyc

HIGVS
 . |.
nlrvt
subfamily_Ptp69D_pd Subfamily Ptp69D 510-587 1.2e-16 55.8 In-house 228-305 (307) alignment 
Range on Protein: 510-587
Range on HMM: 228-305/307.0
AGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEALTCGNTEIQSENFNQTTQKL
|||.|.|... .| .|.| |.  .||| .    ||..|. .||  ||| |.. |.|.  . |.|... ...... ..|
aGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledaierl
PTPc_DSPc_SM00012 510-566 2.2e-16 55.3 In-house 48-105 (105) alignment 
Range on Protein: 510-566
Range on HMM: 48-105/105.0
AGVERTGTYIVIDAMLEQAKKS-RTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLE
||| ||||....| .|.| .|. ..||| ... .||| ||.||||.|||||.. |.||
aGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyralle
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 508-567 2.7e-16 54.5 In-house 219-278 (288) alignment 
Range on Protein: 508-567
Range on HMM: 219-278/288.0
LAAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEA
 .||| ||||.|..||.... ... ..|. . .  ||| |. .|||..|| ||....|. 
CsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsl
Y_phosphatase Protein-tyrosine phosphatase 510-566 3e-16 54.9 Pfam-A 179-235 (235) alignment 
Range on Protein: 510-566
Range on HMM: 179-235/235.0
AGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLE
|||.||||....|..|||... ..||. ...  ||| ||.|||. ||| |.. |.||
aGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 510-566 3e-16 54.9 In-house 179-235 (235) alignment 
Range on Protein: 510-566
Range on HMM: 179-235/235.0
AGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLE
|||.||||....|..|||... ..||. ...  ||| ||.|||. ||| |.. |.||
aGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 560-723 1e-15 52.0 In-house 31-186 (244) alignment 
Range on Protein: 560-723
Range on HMM: 31-186/244.0
IHSAVLEALTCGNTEIQSENFNQTTQKLASVNRKFQMTGYALEFQRLNSVTSHEiPAEEKSVgEEPQNLHKNRFSDIIALNSCRVMLHKEHAdeESDYIN
  .||| | .. |  |.   |..|   |.| ...      |   |  ...   . |.  | .  .|.| .||| .  . ..  || | |        |||
qtnavlsanatknryinilpfdetrvilssskkegsdyinanyiqgsqniirpd.psvmkda.fnpnnswknregaglpfdfnrvplskgsm..gntyin

AVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHELDqeypEYWPDHGPTKY
| |.        .| ||||| .|  |||.|. .  .  .|.| |. | |    |||||  | ..
asfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed....eywpdseplew
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 311-407 3.2e-15 50.1 In-house 3-95 (95) alignment 
Range on Protein: 311-407
Range on HMM: 3-95/95.0
KPIPIALFPEYVAKMQANGGIRLETEYKKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLErvnGDEDSDYINASFIHGYDGTpRSFIASQG
||| ...|  .| .|..|    .. |.|  .     |. .    ||  |||. ||. || .||||       ||||||| |. ||      .||.||
kpihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlt...tkrdsdyinacfvdgyark.ncyiaaqg
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 575-719 3.6e-15 50.4 In-house 9-144 (290) alignment 
Range on Protein: 575-719
Range on HMM: 9-144/290.0
IQSENFNQTTqklaSVNRKFQMTGYALEFqrLNSVTSH-EIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKehaDEESDYINAVFLHAHrgRNAFI
.|.| |.. .    |   | .. ..| |.  |. .  .      |... ..  ...|||. |..  .  ||.|.      . ||. | ...    .  ||
vqteafekfa....sdvvkknvdelakey..leklkpylpvqylerkifdkntefkknrykdvvcndktrvilkd...GydGdyvhanyvkGl..kamfi

ATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHELDQE-YPEYWPDHG
 || .| .|| |.|||| . .. .||||  | |  .    .|.|.. 
ltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypeke
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 358-465 4.1e-15 50.0 In-house 50-170 (349) alignment 
Range on Protein: 358-465
Range on HMM: 50-170/349.0
NKNRYANIVAYDHSRVVLERVN--------------GDEDSDYINASFIHGYDGTP-RSFIASQGPLPPTFEDFWRMVWEQNSQSIVMLTNLVELNKTKC
 |||| .|. |.||||.|..                .    ||||| ...    .. . .|| | ||| | .||....  .. . .. |..  ||.  ||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

HKYWPDKieTYGGVTVTLHQSEL
..|| .   .| ..|| |  | |
diywqel..sysnitvklqnssl
subfamily_egg_pd Subfamily egg 620-717 4.2e-15 50.2 In-house 33-129 (307) alignment 
Range on Protein: 620-717
Range on HMM: 33-129/307.0
SVGEEPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHELdQEYPEYWPD
    .  ||.| |   .   .|.|| |. ..     |.| |  .. .   | || .| || .||.||||||   ..  ||||.|  |  .. . ||| 
ttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes.erceyywpk
subfamily_eak_pd Subfamily eak 355-504 4.6e-15 49.8 In-house 51-198 (332) alignment 
Range on Protein: 355-504
Range on HMM: 51-198/332.0
ANKNKNrYANIVAYDHSRVVLERVNGDEDsDYINASFIHgYDGTPRSFIASQGPLPPTFEDFWRMVWEQNSQSIVMLTNLVELNKTKCHKYWPDKI---E
 . |.|   .|| ||.  | |     ...  ||||| .  .    | .| .  .       ||.|| ||.| .||.| . |||.  |  ||.|||     
eavnrn.vvkivpydrylvrltssqlnrl.Gyinaslae.fsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreel

TYGGVTVTLHQSELFADYEIRTFILSKAKRsgSRMVRQFHFTVWPDKGVPQYA
 .| . |.  .    . .| | ..|||     .  |  ...  | .  .|.| 
kfGildverkefvkrniletrllelskGne..thrvlhykvfGwtettlpkye
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 510-583 2.5e-14 47.8 In-house 208-281 (283) alignment 
Range on Protein: 510-583
Range on HMM: 208-281/283.0
AGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEALTCGNTEIQSENFNQT
.|. ||...| . | ...|. .  ||. . .  .|..|. .|||..|| ..| .|||   ||.|.|   .. .|
tgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdlqst
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 509-569 3e-14 47.8 In-house 216-277 (281) alignment 
Range on Protein: 509-569
Range on HMM: 216-277/281.0
AAGVERTGTYIVIDAMLEQAK-KSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEALT
.||| |||||| .| ...... . ...|... .  |||.|  ||||  || |.. |||.|| 
saGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
0051429 (Phosphotyrosine protein) phosphatases II 655-731 3.3e-14 48.7 In-house 4-95 (272) alignment 
Range on Protein: 655-731
Range on HMM: 4-95/272.0
SDYINAVFLHAHRG---RNAFIATQHPLLETVEDFWRMvTDYDIGTIVMLNSLHELDQEY-PEYWP------------DHGPTKYGHIGVSVL
|.|||| ..    .   .........||  |..||||.  ...| |||.| |..|....  . |||            .. .  ||.. | .|
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtll
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 608-717 3.7e-14 47.1 In-house 18-129 (281) alignment 
Range on Protein: 608-717
Range on HMM: 18-129/281.0
SVTSHEIPAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHK-EHADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHE
|    . |..  .| ..| | .|||...| .|.  || |.      . .||| | ....   .  .| || |  ||  |||||. . .  .||||  . |
snlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfle

LDQEY-PEYWPD
 ..|   ||.| 
tnrekcaeyfpr
subfamily_PTPN13_pd Subfamily PTPN13 509-569 6.4e-14 46.9 In-house 210-270 (273) alignment 
Range on Protein: 509-569
Range on HMM: 210-270/273.0
AAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEALT
.||. |.||.|.||..|.  .. . .|... .  ||. |  .||||.||.|.. |.||.|.
saGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_CG42327_pd Subfamily CG42327 628-729 8.2e-14 46.0 In-house 29-136 (319) alignment 
Range on Protein: 628-729
Range on HMM: 29-136/319.0
LHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHAHR-GRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHELD-QEYPEYWPDH----GPT
  |.|. ... |   ||.|..   |... |..| ..  ..  .| .||.| .| ..  ||||.| .    .|| | .|.||  .  .||.| .    .  
kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnts

KYGHIGVS
 ||.| |.
lyGdilvt
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 400-506 8.4e-14 46.2 In-house 5-116 (199) alignment 
Range on Protein: 400-506
Range on HMM: 5-116/199.0
RSFIASQGPLPPTFEDFWRMVWEQNSQSIVMLTNLVELNKTKCHKYWPDK---IETYGGVTVTLHQSELFADYEIRTFILSKAKR--SGSRMVRQFHFTV
| .||.| ||  |. |||.||||  |  |||. .    ...    |||        || ..|| .     .|| | ..||..       .| . .. || 
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDKGVPQYATA
| .|  |. |  
wkekttpnvalf
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 400-506 9e-14 46.1 In-house 4-115 (198) alignment 
Range on Protein: 400-506
Range on HMM: 4-115/198.0
RSFIASQGPLPPTFEDFWRMVWEQNSQSIVMLTNLVELNKTKCHKYWPDK---IETYGGVTVTLHQSELFADYEIRTFILSKAKR--SGSRMVRQFHFTV
| .||.| ||  |. |||.||||  |  |||. .    ...    |||        || ..|| .     .|| | ..||..       .| . .. || 
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDKGVPQYATA
| .|  |. |  
wkekttpnvalf
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 626-716 1.7e-13 45.3 In-house 42-129 (288) alignment 
Range on Protein: 626-716
Range on HMM: 42-129/288.0
QNLHKNRFSDIIALNSCRVMLHkehaDEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHELDQEYPEY-WP
.|  ..|. ..   . .|| |.    |.   ||.|  . ... .. .| .| ||  |.| .|.|. . |.  ||||. | |. .|  .  .|
anptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfP
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 668-717 1.9e-13 44.6 In-house 234-281 (440) alignment 
Range on Protein: 668-717
Range on HMM: 234-281/440.0
GRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHelDQEYPEYWPD
 .||||||| ||  || ||||.| || | ||.||| |   |.    ||| 
kknafiatqmpldstvldfwrlvhdyristiimlnqln..dktcsiywpv
0043147 (Phosphotyrosine protein) phosphatases II 652-721 2e-13 45.9 In-house 2-79 (172) alignment 
Range on Protein: 652-721
Range on HMM: 2-79/172.0
DEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHELDQEYPE--------YWPDHGPT
|| |||||| .|. ..  . ||||| || .|..|||||. ...|..||.|..|  . . . .        .|||||..
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 509-571 2.1e-13 44.4 In-house 5-67 (69) alignment 
Range on Protein: 509-571
Range on HMM: 5-67/69.0
AAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEALTCG
..|  ||||.| |   . . |  . ||| | .  .|| || ||  ...|.||| |. |||  |
ssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG
subfamily_CG7180_pd Subfamily CG7180 510-572 2.1e-13 44.6 In-house 232-294 (296) alignment 
Range on Protein: 510-572
Range on HMM: 232-294/296.0
AGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEALTCGN
 |. |.| |. ||| ||...|   ||. ...  ||..||..|...|.| .|   .|||. |. 
dGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk
fn3 Fibronectin type III domain 1-82 3e-13 42.9 Pfam-A 3-85 (85) alignment 
Range on Protein: 1-82
Range on HMM: 3-85/85.0
PSSLNSKAMTSTSIRVTWSTLPetCTNGIVRKYVISYHKDGGSN-ETTEVIGAPT-SFDINNLAKYTKYTIKVRGYTVK-EGPWS
|. |. ...||||....||  .    .| . .| . | ..||.. ...  . ..| |. ...|  .|.|...|. .. . |||.|
PenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 351-499 3e-13 44.0 In-house 91-234 (244) alignment 
Range on Protein: 351-499
Range on HMM: 91-234/244.0
ARKPANKNKNRYANIVAYDHSRVVLERvnGDEDSDYINASFIhGYDGTPRSFIASQGPLPPTFEDFWRMVWEQNSQSIVMLTNLVELnktkcHKYWPDK-
| .| |  ||| .  . .| .|| | .  |     ||||||. |  |    .| .| ||  |  |||.|. |.  . .|.|  . |       .||||  
afnpnnswknregaglpfdfnrvplsk..gsmgntyinasfv.gclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdse

-IETYG-GVTVTLHQSELFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKG
 .| |   .|||| . . | .     . .        . .  |  . ||  |
plewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdg
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 509-571 3.3e-13 43.8 In-house 6-68 (69) alignment 
Range on Protein: 509-571
Range on HMM: 6-68/69.0
AAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEALTCG
..|  ||||.| |   . . |  . ||| | .  .|| || ||  . .|.||| |. |||  |
ssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG
subfamily_PTPN9_pd Subfamily PTPN9 509-566 3.6e-13 44.2 In-house 231-288 (297) alignment 
Range on Protein: 509-566
Range on HMM: 231-288/297.0
AAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLE
.||. ||||.| .|  |.. ..  |||... .  ||. | ...|| ||| | . ||||
saGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 510-574 5e-13 43.4 In-house 235-299 (301) alignment 
Range on Protein: 510-574
Range on HMM: 235-299/301.0
AGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEALTCGNTE
..| |.|.|. ..  |||.|    ||. .   |.|. .| .|.| ||| .|. .. . |.. .|.
dtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnsty
fn3 Fibronectin type III domain 97-184 6.3e-13 41.9 Pfam-A 2-85 (85) alignment 
Range on Protein: 97-184
Range on HMM: 2-85/85.0
PPLGVNHTEINSTTFNISWDPIPkdQSNGIITSYDLELSSGQARRrrRSLPESLNSTLTYIVLHNLENCTIYHLRVRARTGKGPGPYS
.| ... .|..||....||.| .  . .| ||.|..|... .  .   .   .. .| |  .|..|.  | |..||.|..|.| ||.|
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekggge..ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_PTPN12_pd Subfamily PTPN12 509-568 7.5e-13 43.0 In-house 215-277 (290) alignment 
Range on Protein: 509-568
Range on HMM: 215-277/290.0
AAGVERTGTYIVIDAMLEQ---AKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEAL
.||| |||| |.|| . |.    | . ..|. . .. |||.|. .||||||| ... ||.| .
saGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 509-566 8.4e-13 42.9 In-house 205-262 (270) alignment 
Range on Protein: 509-566
Range on HMM: 205-262/270.0
AAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLE
.|||.|||| |..| ...  .... ||. . . .|||||. .||. ||| |.. ||.|
saGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 509-566 1.2e-12 42.6 In-house 209-266 (274) alignment 
Range on Protein: 509-566
Range on HMM: 209-266/274.0
AAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLE
.||. ||| .| |.  . | ... .||. .    || ||  ||||.||| .|| |. .
saGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 625-718 1.2e-12 42.5 In-house 39-131 (307) alignment 
Range on Protein: 625-718
Range on HMM: 39-131/307.0
PQNLHKNRFSDIIALNSCRVMLHKEHAdeESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHELDQ-EYPEYWPDH
  | .|||..|. . . .|.... . .   |||| | .|      . ||..| || .|. .|| |. . .. ...||  . || .    .|||  
santdknryqdvkcqdkgrivvkfdgl..asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywple
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 510-575 1.8e-12 41.9 In-house 220-285 (287) alignment 
Range on Protein: 510-575
Range on HMM: 220-285/287.0
AGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEALTCGNTEI
..| |..... ..  ....|.  ..|. . |   |  .|..||| ||| ||  .||| |....|  
dtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetys
subfamily_PTPN6_pd Subfamily PTPN6 509-566 3.1e-12 41.1 In-house 235-295 (306) alignment 
Range on Protein: 509-566
Range on HMM: 235-295/306.0
AAGVERTGTYIVIDAMLEQAKKS---RTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLE
.||. ||||.||||..|.. .|.     .||..    .|. |  .|||..|| |.. |. .
saGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikk
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 355-502 3.5e-12 40.5 In-house 46-188 (303) alignment 
Range on Protein: 355-502
Range on HMM: 46-188/303.0
ANKNKNRYANIVAYDHSRVVLervngdEDSDYINASFIHgYDgTPRSFIASQGPLPPTFEDFWRMVWEQNSQSIVMLTNLVELNKTKCHKYWPDKIET--
 | .|||.....  |||.| |       || || ||...  | . .  | .| ||. |  |||.|. ||. . ...|    | .|   .  .| . .   
knmdknrfvdvicldhskvkl......sdssyihasyle.ld.sskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflk

---YGGVTVTLHQSELFADYEIRTFILSKAkrSGSRMVRQFHFTVWPDKGVPQ
          ... ||   . ..   .|.   .   ..   |.  || . .| 
feersirvgefkrvelgdgwvlkvlsvsng..dyksflhvhhykawphnsips
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 623-707 3.9e-12 40.5 In-house 44-125 (305) alignment 
Range on Protein: 623-707
Range on HMM: 44-125/305.0
EEPQNLHKNRFSDIIALNSCRVMLHKEHAdeeSDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHEL
 | |. .|||. |.  |.  || |.        .|| | .. .    . || || || .|  ||| |  .  . .| ||  | | 
keaqeagknrykdvgcldnnrvklegpwp...heyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllek
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 666-731 4e-12 40.7 In-house 1-69 (199) alignment 
Range on Protein: 666-731
Range on HMM: 1-69/199.0
HRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHELDQ-EYPEYWPD--HGPTKYGHIGVSVL
|.|.  .||||||| ||. |||.|| .   | |||.|      . .|| |||    | .||| . |.. 
hkgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttk
0048076 (Phosphotyrosine protein) phosphatases II 447-565 4.4e-12 41.4 In-house 4-140 (145) alignment 
Range on Protein: 447-565
Range on HMM: 4-140/145.0
PDKIET---YGGVTvTLHQSELFADYEIRT-FILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVL--------------------AAGVERTGTYIVID
|..|     .|... | .. ||..|. |.| . |.  ..  .|.. |.... ||| |||. .  .|                     ||| ||||.....
pseilpglylgslp.taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaay

AMLEqakksRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVL
 ||.     . |.. . |  .|. ||..|.. .|. |.. ..|
lmll.....lgvsleealelvrsqrpgavpnpgqlrflyefel
0046846 (Phosphotyrosine protein) phosphatases II 648-719 9.2e-12 40.6 In-house 5-88 (176) alignment 
Range on Protein: 648-719
Range on HMM: 5-88/176.0
KEHADEESDYINAVFLHAHRgrnaFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHELDQEY-PEYWPD---------------HG
. . |. .||||| ..  .|    .||||.|| .|..||..|. ...|...|.|....||..   | |||.               ||
llgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhg
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 624-707 1.3e-11 38.6 In-house 44-120 (303) alignment 
Range on Protein: 624-707
Range on HMM: 44-120/303.0
EPQNLHKNRFSDIIALNSCRVMLHkehadeESDYINAVFLHAHRGRNAfIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHEL
  .|..|||| |.| |.  .| |       .| || | .|. .  ..| | || ||  |  |||.|. .  .  ...| .  | 
fvknmdknrfvdvicldhskvkls......dssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdsey
0036282 (Phosphotyrosine protein) phosphatases II 655-719 1.3e-11 40.0 In-house 2-81 (174) alignment 
Range on Protein: 655-719
Range on HMM: 2-81/174.0
SDYINAVFLHAHRGRNAFIATQHPLLetvedFWRMVTDYDIGTIVMLNSLHELD-QEYPEYW-------------------PDHG
|||||| .|. ..  . .||.|.||      ||.|. ...| |.|||....||.    . ||                   ||||
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhg
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 668-731 1.6e-11 38.8 In-house 2-68 (198) alignment 
Range on Protein: 668-731
Range on HMM: 2-68/198.0
GRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHELDQ-EYPEYWPD--HGPTKYGHIGVSVL
|.  .||||||| ||. |||.|| .   | |||.|      . .|| |||    | .||| . |.. 
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttk
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 339-451 1.9e-11 37.1 In-house 9-88 (169) alignment 
Range on Protein: 339-451
Range on HMM: 9-88/169.0
KFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINAsfihgydgtprsfiasqgplpptfedfwRMVWEQNSQSIVMLTNLVELN
.| .  ..    |   .|. ||| |  .|  | || |.||  |  ||||||                            ||.|| |.  ||.| .  . |
efmktieynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlGdtddkn

ktkchKYWPDKIE
      .||.| .
.....nfwpeked
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 510-572 2.1e-11 38.2 In-house 225-287 (290) alignment 
Range on Protein: 510-572
Range on HMM: 225-287/290.0
AGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEALTCGN
..| |........  ....|.   .|. . |  .|  .| .|||..|| .|.. ||..|.. .
dtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfe
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 338-450 2.6e-11 36.8 In-house 9-88 (169) alignment 
Range on Protein: 338-450
Range on HMM: 9-88/169.0
KKFNNGQQFPWEAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINAsfihgydgtprsfiasqgplpptfedfwRMVWEQNSQSIVMLTNLVEL
|.| .  ..    |   .|. ||| |  .|  | || |.||  |  ||||||                            ||.|| |.  ||.| .  . 
kefmktieynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlgdtddk

NktkchKYWPDKI
|      .||.| 
n.....nfwpeke
0048179 (Phosphotyrosine protein) phosphatases II 464-562 4.4e-11 38.2 In-house 23-139 (144) alignment 
Range on Protein: 464-562
Range on HMM: 23-139/144.0
ELFADYEIRTFI---LSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVL--------------------AAGVERTGTYIVIDAMLeqakkSRTVDIRNYL
||.... |.| |    .  . .  |.. |.... ||| |||.... .|                     ||| ||||..... |.      . ... . |
ellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk.....klglsleeal

IALRKDRPHMVQTKEQYLFIHS
  .|. ||..|.. .|. |.. 
alvrsrrpgavpnpgqlrfLle
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 654-730 5.4e-11 36.9 In-house 12-84 (130) alignment 
Range on Protein: 654-730
Range on HMM: 12-84/130.0
ESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHELDqeypEYWPDHGPTKYGHIGVSV
. .|||| |.      . .. ||||| .|  |||.|. .  .  .|.| |. | |    |||||  | ..    . |
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed....eywpdsePlewyeediiv
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 623-700 6.2e-11 36.4 In-house 33-115 (347) alignment 
Range on Protein: 623-700
Range on HMM: 33-115/347.0
EEPQNLHKNRFSDIIALNSCRVMLHKEH-----ADEESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVM
|  ..| |||  |    .. ||.|  |.     ||.   ||||  ..    .. .| ||.|| .|| |||.||.   .  .| 
ewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 658-718 6.6e-11 36.5 In-house 78-139 (301) alignment 
Range on Protein: 658-718
Range on HMM: 78-139/301.0
INAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHELD-QEYPEYWPDH
| | .. ..   . ||||| || .| |||| |.. ||. .||||    |   .   || | .
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvk
subfamily_PTPRN_pd Subfamily PTPRN 510-567 8.2e-11 36.1 In-house 233-291 (297) alignment 
Range on Protein: 510-567
Range on HMM: 233-291/297.0
AGVERTGTYIVIDAMLEQAKK-SRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEA
.|. |||.||.|| .|.. .|  . .||   |  || .||..|.||.|. |. .|| | 
dGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaee
0049260 (Phosphotyrosine protein) phosphatases II 666-722 8.2e-11 37.3 In-house 5-69 (152) alignment 
Range on Protein: 666-722
Range on HMM: 5-69/152.0
HRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHELDQEYPEY--------WPDHGPTK
..  ..|||||.|. .|..|||||. ...|.|||||..|.||. .. |.        |||||. .
yampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpd
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 627-710 9.3e-11 36.2 In-house 35-115 (285) alignment 
Range on Protein: 627-710
Range on HMM: 35-115/285.0
NLHKNRFSDIIALNSCRVMLhKEHadeESDYINAVFLHA-HRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHELDQE
|   ||..|. ...  ||.| |.|   . ||| | ...   . ....|.|| || ||. |||.|. .  |  ..|| .| |   |
npdlnryadvrcieetrvvl.knh...drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggve
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 356-430 1e-10 35.7 In-house 37-115 (347) alignment 
Range on Protein: 356-430
Range on HMM: 37-115/347.0
NKNKNRYANIVAYDHSRVVLER-----VNGDEDSDYINASFIHgYDGTPRSFIASQGPLPPTFEDFWRMVWEQNSQSIVM
. .|||  .    | .||||        . |.   ||||| |. .| . . .| .| ||| |  |||.||   .   .| 
slsknrskdvklidatrvvlspeksknsraddvetyinashik.fdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 355-506 2.1e-10 34.5 In-house 50-202 (302) alignment 
Range on Protein: 355-506
Range on HMM: 50-202/302.0
ANKNKNRYANIVAYDHSRVVLERvngdEDSDYINASFIHGYDGTpRSFIASQGPLPPTF---EDFWRMVWEQNSQSIVMLTNLVELNKtKCHKYWPDKIE
.| .||.  .. ..|. .| ||     |  .|.||| ..  . | || | .| |   .    |.|||||.... .|.|.|    ||.|   ....| | .
knlkknqsedvpildsnlvklea....epdsyvnaskvevPelt.rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksg

---TYGGVTVTLHQSELFADYEiRTFIL--SKAKRSGSRMVRQFHFTVWPDKGVPQYATA
   .|| . |   . |   . .   ...       | | ..   ..| |..| ||.  ..
dykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyae
subfamily_PTPN14_pd Subfamily PTPN14 509-568 2.8e-10 34.7 In-house 237-296 (300) alignment 
Range on Protein: 509-568
Range on HMM: 237-296/300.0
AAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEAL
.||| |||  |. | ...  .. ...||.. |  ||. | ..|||  || |....... |
saGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_PTPN1_pd Subfamily PTPN1 509-574 4.1e-10 33.9 In-house 209-279 (290) alignment 
Range on Protein: 509-574
Range on HMM: 209-279/290.0
AAGVERTGTYIVIDAMLEQAKKSR---TVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEALTC--GNTE
.||. |.||....|..| . .|.    .|||.. |..||| |  ..||..|  | . |.||   .  |.. 
saGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdss
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 359-477 5.1e-10 34.0 In-house 22-151 (290) alignment 
Range on Protein: 359-477
Range on HMM: 22-151/290.0
KNRYANIVAyDHSRVVLERVNGDEDSDYINASFIHGYDGTprSFIASQGPLPPT-------FEDFWRMVWEQNSQSIVMLTNLVELNKT----KCHKYWP
..|... ..  ..||||.       .||| |...   .|    .|..| |.  .        |.|| |. . .....||| .  | ..      | || |
dqRlevpLv.eatrvvLkgygkrfnddyiHAnrvtcpngl..rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvp

DKIE---TYGGVTVTLHQSELFADYEIRTFILS
....   ...|.||   . |   | |.|. .. 
esvgeelkfkgltvkCkskekeddvetRelvvk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 400-476 7.6e-10 32.7 In-house 236-311 (440) alignment 
Range on Protein: 400-476
Range on HMM: 236-311/440.0
RSFIASQGPLPPTFEDFWRMVWEQNSQSIVMLTNlveLNKTKCHKYWPDK--IETYGGVTVTLHQSELFADYEIRTFIL
 .|||.| ||  |  ||||.| . .  .|.|| .   ||   |  ||| .    |.|  ||  . || .    .||. |
nafiatqmpldstvldfwrlvhdyristiimlnq...lndktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlel
0051082 (Phosphotyrosine protein) phosphatases II 655-720 8.9e-10 33.9 In-house 3-58 (151) alignment 
Range on Protein: 655-720
Range on HMM: 3-58/151.0
SDYINAVFLHAHrgrnaFIATQHPlletVEDFWRMVTDYDIGTIVMLNSLHELDqEYPEYWPDHGP
|||||. ..  .     ......|     .||.... ...| |||.|.|..| .  .|||.|..| 
sdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg.ycpeylpelgi
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 509-568 1.6e-09 32.1 In-house 236-295 (297) alignment 
Range on Protein: 509-568
Range on HMM: 236-295/297.0
AAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEAL
.||| |.|  .  |..|.. .| |  |..  |  ||. |. .||| ||. ....|||. |
saGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 627-717 1.7e-09 31.8 In-house 55-144 (305) alignment 
Range on Protein: 627-717
Range on HMM: 55-144/305.0
NLHKNRFSDIIALNSCRVMLHKEHadeESDYINAVFLHAHR-GRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHELDQ-EYPEYWPD
.  |||..|. . .   | |.|      |||| | .. .     . ||..| || .|...|| || .  .  ||||    || .    .||| 
aitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpa
subfamily_PTPN3_pd Subfamily PTPN3 509-567 2e-09 31.8 In-house 216-274 (280) alignment 
Range on Protein: 509-567
Range on HMM: 216-274/280.0
AAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEA
.||..||| .|...  |    ... | . . .  .|  |  .|||..|| |.  |.|..
saGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 408-568 3.1e-09 30.7 In-house 99-288 (302) alignment 
Range on Protein: 408-568
Range on HMM: 99-288/302.0
PLPPTFEDFWRMVWEQNSQSIVMLTNLVELNKTKCHKYWPDKIE---TYGGVTVT---LH-QSELFADYEI---RT--FILSKAKRSGSRMVRQFHFTVW
|   | | .| .. . |   .| |...|| .. || .|. ||..   ..|  ||.   .. . | |.| .     |  .  .| |.   . |  ..|. |
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PDKGVPQ--------------YATAVL---AAGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEAL
||.| |.              | ..||   .||| |||| . |   ..  .| .. |. . .. .|. |   ||...| ...   |  .|
pdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkgl
subfamily_CG42327_pd Subfamily CG42327 509-563 3.1e-09 30.9 In-house 255-310 (319) alignment 
Range on Protein: 509-563
Range on HMM: 255-310/319.0
AAGVERTGTYIVIDAMLEQAKKS-RTVDIRNYLIALRKDRPHMVQTKEQYLFIHSA
. || |||. |  |  ... ..| |.||| . .  .|.|| . |.||||| ||.  
sdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 412-508 5.7e-09 30.4 In-house 40-139 (255) alignment 
Range on Protein: 412-508
Range on HMM: 40-139/255.0
TFEDFWRMVWEQNSQSIVMLTNLVELNKTKCHKYWP---DKIETYGGVTVTLHQseLFADYEIRTFILS-K-AKRSGSRMVRQFHFTVWPDKGVPQYATA
| . |....  .... .|||... | .. ||..|.|   |.   .  |.||  .    ||  .||  .  . ...   . |. .... |..|  |. |  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

VL
.|
il
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 355-440 5.8e-09 29.9 In-house 33-116 (332) alignment 
Range on Protein: 355-440
Range on HMM: 33-116/332.0
ANKNKNRYANIVAYDHSRVVLERVNGDedSDYINASFIHGYDGTpRSFIASQGPLPPTFE-DFWRMVWEQNSQSIVMLTNLVELNKT
 | . ||   . ..||||| |   .|    |. |||.. ||     ..| .| |.    |  ||||| |..   |... .. | .| 
nnmdmnriphlycfdhsrvelapqdgk..ddfynaswvdgyskk.sayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkr
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 615-717 6e-09 29.7 In-house 36-155 (349) alignment 
Range on Protein: 615-717
Range on HMM: 36-155/349.0
PAEEKSVGEEPQNLHKNRFSDIIALNSCRVMLHKE--------HADEE------SDYINAVFLHAHRG--RNAFIATQHPLLETVEDFWRMVTDYDIGTI
....  . |  .   |||..||.  .  ||.|.|         ..  |       ||||| .|.  |    . .|||| ||  ||.||.....   .  .
eiddvilseGvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklv

VMLNSLHELDQEY-PEYWPD
. ||. .||. |    || .
lsLnddkelslekcdiywqe
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 368-499 8e-09 29.9 In-house 5-125 (130) alignment 
Range on Protein: 368-499
Range on HMM: 5-125/130.0
YDHSRVVlervngdeDSDYINASFIhGYDGTPRSFIASQGPLPPTFEDFWRMVWEQNSQSIVMLTNLVELnktkcHKYWPDK--IETY-GGVTVTLHQSE
.. ||.         . .||||||. |  |  . .. .| ||  |  |||.|. |.    .|.|  . |       .||||   .| |   ..||| . .
fevsrlq........gntyinasfv.Gllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdrd

LFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKG
 |   .   .  ..      . .  |. . ||  |
efknikasnleiesdlneshqaltmfqisnwpsdg
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 619-676 5.7e-08 26.8 In-house 40-94 (95) alignment 
Range on Protein: 619-676
Range on HMM: 40-94/95.0
KSVGEEPQNLHKNRFSDIIALNSCRVMLHKEhadEESDYINAVFLHAHRGRNAFIATQ
 .||    |. |||| .|.  .. ||.|       .||||||.|.  .  .|..||.|
ytvgsseanipknrflnifpydatrvvlttk...rdsdyinacfvdgyarkncyiaaq
0044763 (Phosphotyrosine protein) phosphatases II 641-727 1.1e-07 27.2 In-house 4-82 (178) alignment 
Range on Protein: 641-727
Range on HMM: 4-82/178.0
SCRVMLHKEHADEESDYINAVFLHAHrgrnaFIATQHPLletvEDFWRMVTDYDIGTIVMLNSLHELD-QEYPEYWPDHGPTKYGHIG
 .|| |..    | ||||||..   .     ......|     .|..... ...|..||.|..  ||  .....|||.    .| ||.
rtrvllsnleglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeagiqylhip
subfamily_eak_pd Subfamily eak 613-729 1.2e-07 25.4 In-house 38-155 (332) alignment 
Range on Protein: 613-729
Range on HMM: 38-155/332.0
EIPAEEKSVGEEPQNLHKNrFSDIIALNSCRVMLHKEHADeESDYINAVFLHAHRGRNAFIATQHPLLETVEDFWRMVTDYDIGTIVMLNSLHELDQ-EY
  ..  .|...  .....|   .|.  .   | |     . .  ||||  .      . .| |  .  . |  ||.|| .    .||.|    ||.  ..
yqrllsisetarleavnrn.vvkivpydrylvrltssqln.rlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleks

PEYWPDHG--PTKYGHIGVS
  |.||..    |.|.. | 
dkyfpdktreelkfGildve
subfamily_hpo-7_pd Subfamily hpo-7 412-507 1.9e-07 25.2 In-house 46-144 (263) alignment 
Range on Protein: 412-507
Range on HMM: 46-144/263.0
TFEDFWRMVWEQNSQSIVMLTNLVELNKTKCHKYWP---DKIETYGGVTVTLHQSELfaDYEIRTFILSK--AKRSGSRMVRQFHFTVWPDKGVPQYATA
| . |....  .... .|||..  | .. || .|.|   |.   .  |.|.  ..    |  ..|  | .   ..   . |... .. |..|  |. |  
tidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpelare

V
.
i
subfamily_PTPN23_pd Subfamily PTPN23 509-567 2e-07 25.1 In-house 220-279 (288) alignment 
Range on Protein: 509-567
Range on HMM: 220-279/288.0
AAGVERTGTYIVIDA-MLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEA
 |||.|||.. .. | . |  |.   .|| . .  ||..| .|||.|||. |  .|||||
saGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 349-396 2.2e-07 24.8 In-house 32-78 (244) alignment 
Range on Protein: 349-396
Range on HMM: 32-78/244.0
EAARKPANKNKNRYANIVAYDHSRVVLERVnGDEDSDYINASFIHGYD
  |   ||  |||| ||. .|..||.|      | ||||||..|.| .
tnavlsanatknryinilpfdetrvilsss.kkegsdyinanyiqgsq
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 626-717 5.2e-07 23.4 In-house 50-140 (302) alignment 
Range on Protein: 626-717
Range on HMM: 50-140/302.0
QNLHKNRFSDIIALNSCRVMLHKEhadeESDYINAVFLHAHRGRNAFIATQHPLLETV---EDFWRMVTDYDIGTIVMLNSLHELDQEYPEYWPD
.||.||.  |. .|.| .| |..|    . .|.||  ..    ..  | .| | ....   |.||||| .  | ..|.|    ||..   |..| 
knlkknqsedvpildsnlvkleae....pdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpk
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 509-565 7.3e-07 23.2 In-house 270-341 (350) alignment 
Range on Protein: 509-565
Range on HMM: 270-341/350.0
AAGVERTGTYIVIDAMLE-------QAKKSRTVDIRN--------YLIALRKDRPHMVQTKEQYLFIHSAVL
.||| ||||.. .| .|.         |.|| .|  .         .  ||| |  |||...|..||. |.|
saGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeall
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 510-565 1.7e-06 21.7 In-house 227-282 (302) alignment 
Range on Protein: 510-565
Range on HMM: 227-282/302.0
AGVERTGTYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVL
 |. | |. ..  . .|. .|.  . | . ....|..||..|.. .|| ... |.|
nGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiall
subfamily_eak_pd Subfamily eak 509-576 2.2e-06 21.3 In-house 244-313 (332) alignment 
Range on Protein: 509-576
Range on HMM: 244-313/332.0
AAGVERTGTYIVIDAMLE--QAKKSRTVDIRNYLIALRKDRPHMVQTKEQYLFIHSAVLEALTCGNTEIQ
| |  |.|...||| ...  ..||  .  . ....  .. | | | .. |. ||. .||. |   | ...
arGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnrlr
Nt_Gln_amidase N-terminal glutamine amidase 476-558 7.1e-06 11.8 Pfam-A 64-137 (184) alignment 
Range on Protein: 476-558
Range on HMM: 64-137/184.0
LSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAAGVERTGTYividamleqAKKSRTVDIRNYLIALRKDRPHMVQTKEQYL
|..|...|. .|  .  |.     . .|.. .|    . . .|          .| | .. ..||  .. || || ... .||
lvraekegkslvyDlDstldlpsdlkkYveealrldkalkeey.........rrkfRvieadkylsefaSDRsHmkkedgsyl