Gene NvecPTP-sf2-8 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily NvecPTP-sf2
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP051_AA protein Get Run
NvecP051_AA_839-1109 phosphatase_domain Get Run
NvecP051_AA_1122-1365 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 844-1186 3.9e-124 410.4 In-house 28-358 (564) alignment 
Range on Protein: 844-1186
Range on HMM: 28-358/564.0
VFQTLPSGQQFTWEVARRRDNKKRNRYANIIAYDHSRVRL---RDNQESDYINASYLHvkpwrnaegipsvcCVQRPAPFVPCKRPLPVTVADFWQLVWQ
 .... .|||||||.|.   ||..||||||.|||||||.|   . ...|||||||...                ...  ..  . ||. |..|||..||.
eykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfid..............gyrkrkayIAtqgPlaetiedFWRmvwe

EQVTTIVMLTNIVEVGKTKCHRYWPEG-KARHGEFDISLHREEVFADYVVRTFII-KKDEGQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAHYtsR
....||||||...| ||.|||.||||  ....||. ..|. || .|||..|||.. ||.. .||.| ||..|||||.||| .|||.| ..|||||.   .
qnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln..e

NGQVPMLVHCSAGVGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEALTCGNTEIEAGNLQIAMRKRAAVKPTQNLSG
... |..|||||||||||.||.|||||||.|.|||||| .||. .|..| .|.|||.||.|.| |.||||.|||||.|. ||. ...| | |.. .. .|
pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLaeveedtemtg

YALEYQRLLaVSSQIEDENSKVGRADYNIKKNRYPSVVPLDSSRVVLS
..||.|||   ...|| |. .|.  . | ||||.. ...|.|.|||||
leleFqrLa.takeieleefavatkpknkkknrfsnilalescrvvls
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 835-1115 5.8e-121 398.3 In-house 23-297 (298) alignment 
Range on Protein: 835-1115
Range on HMM: 23-297/298.0
VAKISVLVAVFQTLPSGQQ----FTWEVARRRDNKKRNRYANIIAYDHSRVRLRD---NQESDYINASYLHvkpwrNAEGIPsvccvqrpaPFVPCKRPL
  |.... ..||.| |...    ...||||...|||.||||.|||.|.|||.|..   ..||||||||.||     ...| .         .|. ...||
kkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflh.....aykgrn.........afiatqaPl

PVTVADFWQLVWQEQVTTIVMLTNIVEVGKTKCHRYWPE-GKARHGEFDISLHREEVFADYVVRTFII-KKDEGQSRQVVQFQYTSWPDKGVPRHATSVL
. ||.|||..|..|...|||||||..|..|||.|.|||. ||...||...||...|.|||..||.... ||.| ..|.|.|...|||||||||..|||||
tetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvl

GFRRKVRAhYTSRNGQVPMLVHCSAGVGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEALTCGNTEI
...||||| .....|..|..|.|||||||.|.|||||..|||.|||..||....|.|.|..|....|||.||.|.. ||||||...|.||
dllrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1111-1365 9.6e-115 377.9 In-house 1-262 (298) alignment 
Range on Protein: 1111-1365
Range on HMM: 1-262/298.0
GNTEIEAGNLQIAMRKRAAVKPTQNLSGYALEYQRLLAVSSQIEDENSKVGRADYNIKKNRYPSVVPLDSSRVVLSV----DGGDYINASFADAFRKRNA
||||||| .|..|..|.||||....|.|||||.||| .|||.||.|...|.|...| |||||.....||||||||.     . .|||||||..|...|||
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

FILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQE-DTLTYPQYWPSKGSETYDHLNVRLMSREKQGKLISRKLAIGQKV--SEHEVVHIQHIEWPDKCA
||.|||||..|...||.|.....|||||||.||.| |...|..|||..|.|||....|.|.|.|....||.|||.. .|   .|.||.......||||..
fiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgv

PVNHQSVLDLVSWVQLSQQQCGDKAIVVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTV
| |..|||||...|. ||||.|.|...||||.||||||||.||.|.|||.|.||||||||.|
penatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvv
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 844-1146 3.1e-89 294.2 In-house 25-318 (318) alignment 
Range on Protein: 844-1146
Range on HMM: 25-318/318.0
VFQTL-PSGQQFTWEVARRRDNKKRNRYANIIAYDHSRVRLRD---NQESDYINASYLHvkpwrnaeGipsvccVQRPAPFVPCKRPLPVTVADFWQLVW
 .. | .| ...|.  .    ||..||||||.||||.||.|..   ...||||||.|.         |       .|   .. .. ||| |. |||..||
eyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyid........G......yrrkkayiaaqaPlpetieDfWrmvW

QEQVTTIVMLTNIVEVGKTKCHRYWPE-GKARHGEFDISLHREEVFADYVVRTFIIKKD-EGQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAHyTS
. . ..|||||...| ||.|.|||||. |   .|.  . |. |  ..|||.|.| .... | .|||| |..||||||.||| ...|.| . |.|..    
eqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvska.qq

RNGQVPMLVHCSAGVGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEALTCGNTEIEAGNLQIAMRKRAAVKPTQNLS
..|. |..||||||||||| |||.|..|||.|.|..||....|. .|..|  |.|||||| |.. ..||||..|.||..| .|.  .|.   ..| .  .
ksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelreqdpesgtt

GYALEYQRL
   .|.|||
emdaefqrl
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 857-1111 5e-88 289.5 In-house 2-245 (250) alignment 
Range on Protein: 857-1111
Range on HMM: 2-245/250.0
EVARRRDNKKRNRYANIIAYDHSRVRLRDNQ---ESDYINASYLHVKPWRNAegipsvccvqrpapFVPCKRPLPVTVADFWQLVWQEQVTTIVMLTNIV
.||.. .||..||||.|||.|.||| |  ..   ||||||||.||.   |.|              |.  . ||. |. |||..|..|...|||||||..
svakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderka..............fiatqgPlqatiedfWrmvleeksgtivmLtnLk

EVGKTkCHRYWP-EGKARHGEFDISLHREEVFADYVVRTFIIKKDE-GQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAHYtSRNGQVPMLVHCSAG
| .|| .|.||| |.  ..|.  .||. .|.||||..|.... | .  ..|.|.|.....|||||||..||.||....||.|    . |. |..|.||||
esekt.yhqywPvekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasq.qqagnaPvivqCsaG

VGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEALTCG
|||.||||||||.|||.||||.||......|.|..|  ......|| ||. ..|.||.. 
vgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsv
0050432 (Phosphotyrosine protein) phosphatases II 842-1113 1.4e-85 282.6 In-house 45-304 (308) alignment 
Range on Protein: 842-1113
Range on HMM: 45-304/308.0
VAVFQTLPSGQQ-FTWEVARRRDNKKRNRYANIIAYDHSRVRLrdNQESDYINASYLHVKPwrnaegipsvccVQRPAPFVPCKRPLPVTVADFWQLVWQ
 . |..|.| .  ....||.. .||..||| .|..||||||.|  ...|||||||| ..                .|  |. .. ||| ||.|||..||.
eeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl..degsdYInAsyvdgys............sklprkfIatqgPlpntvedFwrmvwe

EQVTTIVMLTNIVEVGKTKCHRYWPE----GKARHGEFDISLHREEVFADYVVRTFIIKK-DEGQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAHY
..|..|||||..|| |. ||..|||.    |  ..| | . | .|||..||.|||..... ..|.||.| .|.||.||| ||| .....| | ..|| ..
qnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl

tsrnGQVPMLVHCSAGVGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEALTCGNT
    .. |..|||||||||||.|||.| .||. .||..||. ..|. .|  |. |.||..|| |.. |.|| | .  |
....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklklt
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 844-1143 3.1e-85 281.1 In-house 28-318 (319) alignment 
Range on Protein: 844-1143
Range on HMM: 28-318/319.0
VFQTLPSGQQFTWEVARRRDNKKRNRYANIIAYDHSRVRLR---DNQESDYINASYLHvkpwrnaeGipsvccVQRPAPFVPCKRPLPVTVADFWQLVWQ
 |..|  ....|.. | . .|||.||| ||.|||..|| |    . ..|||||||..         |       |.   |.  . ||  |. |||..||.
efkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfid........g......yqerekfiatqaPlentiedfWrmvWe

EQVTTIVMLTNIVEVGKTKCHRYWPEGK-ARHGEFDISLHREEVFADYVVRTFIIKKDEGQS--RQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAHyTS
|.. ..||||..|| .| |...|||| .  . |.. . |  ||  .||..| . ..|  ..   |.|..||||.|||..||..|||.| . ...|   ..
eessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirks.re

RNGQVPMLVHCSAGVGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEALTCGNTEIEAGNLQIAMRKRAAVKPTQNLS
.. . |. |||||||||||.||..|||||| |.| ..|....|. .|  | .|.|...|| |.. |.|||...|.||||  .|.  ... |  ..    .
ktqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqlaekvadtget

GYALEY
| . |.
gleref
subfamily_PTPRK_pd Subfamily PTPRK 847-1141 1.4e-84 278.7 In-house 30-310 (314) alignment 
Range on Protein: 847-1141
Range on HMM: 30-310/314.0
TLPSGqqftWEVARRRDNKKRNRYANIIAYDHSRVRLR---DNQESDYINASYLhvkpwrnaegipsvCCVQRPAPFVPCKRPLPVTVADFWQLVWQEQV
.|. |    |..|.. .|...||. .|.|||.|||.|    ....||||||...                 .||| |.  . ||. ||.|||.||..|. 
slfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaali..............dsykrpaafivtqgPlqetvkdfWrlvydenc

TTIVMLTNIVEVGKTKCHRYWPEGKARHGEFDISLHREEVFADYVVRTFIIKK---DEGQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAHYTSRNG
..|||||..||||. || .||||    .|.... | . |. |..|||.| ..|      . |.| |||...||| .|| .||..|.. |.| ..   ..|
asivmltelvevgrvkClkyWPedtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaG

qvPMLVHCSAGVGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEALTCGNTEIEAGNLQIAMRKRAAVKPTQNLSGYA
  ...|||||| ||||.||||| .|. ...|..||..| |  .|...  |..||.|| |.. ..|||  ||.| | . ... .  .   . |  | |   
..rivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalylesirldpqtnssqlk

L
 
e
0040438 (Phosphotyrosine protein) phosphatases II 840-1146 9.1e-84 276.7 In-house 19-314 (317) alignment 
Range on Protein: 840-1146
Range on HMM: 19-314/317.0
VLVAVFQTLPSGQQFTWEVARRRDNKKRNRYANIIAYDHSRVRLRDNQE---SDYINASYLHvkpwrnaegipsvcCVQRPAPFVPCKRPLPVTVADFWQ
.|   |..|.| .  |..||.. .||..||| .|. ||||||.| . ..   |||||||| .              . ...  |. .. ||| ||.|||.
alleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvd..............gpnlkrkfIatqgPlpntvedFwr

LVWQEQVTTIVMLTNIVEVGKTKCHRYWP-EGKARHGEFDISLHREEVFADYVVRTFIIKK-DEGQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAH
.||...||.|||||. .| |. ||..||| ...  .|.| . |  ||. |....||. ... ....||.| .|.||.||| ||| . ...| | ..||..
mvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrea

YTsrNGQVPMLVHCSAGVGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEALTCGNTEIEAGNLQIAMRKRAAVKPTQ
.   ... |.||||||||||||.|||.. |||. .||..||. . |. .|. |. ..||..|| |.. |.|| |....| ..| .|  .. |. .... .
le..dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplald

NLSGYALEYQRL
. ...  |...|
dvklkekelkll
0036941 (Phosphotyrosine protein) phosphatases II 850-1124 1.4e-83 276.0 In-house 25-293 (297) alignment 
Range on Protein: 850-1124
Range on HMM: 25-293/297.0
SGQQFTWEVARRRDNKKRNRYANIIAYDHSRVRLrDNQESDYINASYLHvkpwrnaegipsvcCVQRPAPFVPCKRPLPVTVADFWQLVWQEQVTTIVML
   .....||.. .|...||| .|..|||.||.| |...||||||||.               . ...  |. .. ||| ||.|||..||...||.||||
llllgslsvallpenleknRykdilpydhtRVkl.ddegsdYinAsyvd..............gydlkrkfIatqgPlpntvedFWrmvweqnvtvIvml

TNIVEVGKTKCHRYWP---EGKARHGEFDISLHREEV--FADYVVRTFIIKK-DEGQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAHYTSRNGQVP
|. || |. ||..|||   ..   .|.| . | ..||  ..||..||. ... ..|.||.| .|.||.||| ||| ...|.| | ..|| ..   ... |
telvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggp

MLVHCSAGVGRTGAFIAIDAMLERAK---KEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEALTCGNTEIEAGNLQIAM
.||||||||||.|.|||.| ||.. .   ||..||| ..|. .|. |. ..||..|| |.. |.|| | ...| ... .|  ..
vlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllklvlll
0051299 (Phosphotyrosine protein) phosphatases II 841-1108 6.5e-82 270.5 In-house 25-286 (288) alignment 
Range on Protein: 841-1108
Range on HMM: 25-286/288.0
LVAVFQTLPSGQ-QFTWEVARRRDNKKRNRYANIIAYDHSRVRLRDNQE---SDYINASYLHVKPWRnaegipsvccvqrpAPFVPCKRPLPVTVADFWQ
| . |..|.| . ..|. .|..  |...||| .|..||||||.|.. ..   ||||||||... ..                 |. .. ||| ||.|||.
lleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlk..............rkfIatqgPlpntvedFWr

LVWQEQVTTIVMLTNIVEVGKTKCHRYWP-EGKARHGEFDISLHREEVFADYVVRTFIIKK-----DEGQSRQVVQFQYTSWPDKGVPRHATSVLGFRRK
.||...|..|||||..|| |..||..||| .|.  .|.. . | .|||..||.|||.....      .|.||.| .|.||.||| ||| .....| | |.
mvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrl

VRAHYTsrNGQVPMLVHCSAGVGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEAL
|| ..   .|. |..|||||||||||.|||.| .||. .||..||. ..|. .|. |. |.||..|| ||. |.||.|
vrkala..sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_PTPRB_pd Subfamily PTPRB 852-1110 9e-82 269.4 In-house 39-287 (293) alignment 
Range on Protein: 852-1110
Range on HMM: 39-287/293.0
QQFTWEVARRRDNKKRNRYANIIAYDHSRVRL---RDNQESDYINASYLHvkpwrnaeGipsvccVQRPAPFVPCKRPLPVTVADFWQLVWQEQVTTIVM
.. . ..|..  |...||| ||..||||||.|   .|...||||||.|..        |       . |  |. .. ||| || |||..||......|||
kdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyip........g......ynsprefiatqGPlpetvddfWrmvwekkssiivm

LTNIVEVGKTKCHRYWPEG--KARHGEFDISLHREEVFADYVVRTFIIKKdEGQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAHYTSRNGQVPMLV
||..|| ||.||..|||.      .|.  ..|  ||.  |.|.|.. |.| | ..|.| |...||||| ||| .....| | |.|| . .. . . |..|
ltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek.ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivv

HCSAGVGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEALTC
||||||||||.|||.| .|.. ..| .|||   |  .|..|....|||.|| |.| .||. |. 
hCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk
0046845 (Phosphotyrosine protein) phosphatases II 845-1114 1.4e-81 269.3 In-house 6-280 (284) alignment 
Range on Protein: 845-1114
Range on HMM: 6-280/284.0
FQTLPSGQQ---FTWEVARRRDNKKRNRYANIIAYDHSRVRLRDNQE----SDYINASYLHVKPWRNAegipsvccvQRPAPFVPCKRPLPVTVADFWQL
|..|.| .    ....||..  |...||| .|..||||||.|.  ..    ||||||||...  .             ..  |. .. ||| ||.|||..
feellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldlt.........yikkkfIatqgPlpntvedFwrm

VWQEQVTTIVMLTNIVEVGKTKCHRYWP--EGKARHGEFDISLHREEVFADYVVRTFIIKKD--EGQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRA
||...|..|||||..|| |..||..|||  ... ..|.| . | .|||. ||.|||. ...   .|.||.| .|.|||||| ||| .....| | |.|| 
vweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvre

HYTSRNGQVPMLVHCSAGVGRTGAFIAIDAMLERAKKEK---TVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEALTCGNTE
......|. |..|||||||||||.|||.| .||. .||.   .||. ..|. .|. |. |.||..|| ||. |.||.| ...| 
llenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 845-1126 4.4e-81 267.4 In-house 28-301 (305) alignment 
Range on Protein: 845-1126
Range on HMM: 28-301/305.0
FQTLPSGqQFTWEVARRRDNKKRNRYANIIAYDHSRVRLRDNQE---SDYINASYLHvkpwrnaegipsvcCVQRPAPFVPCKRPLPVTVADFWQLVWQE
...|..  . . .| ..  ||..||...|. .|..|..|. ...   ||||||||..                .|   ..  . ||. ||||||.|...|
ykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvd..............gykrkkkyivaqgPlkntvadfWrlivee

QVTTIVMLTNIVEVGKTKCHRYWPEGKAR---HGEFDISLHREEVFADYVVRTFIIKK--DEGQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAHYT
.|.||||||..|| || ||..|||| |..   .||| . |. |. ..||. | . | .  .. .||.|.|.| |.|||.|||. |||.| . ..|. .. 
kvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqk

sRNGQVPMLVHCSAGVGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEALTCGNTEIEAGNLQIAMRK
 .. .||.||||||||||||.|||.| .|||.|||..||. .... .|..|  |.|| ||| |.| |. | .|||.|.|   ||.... |
.kdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvnk
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 842-1109 6e-81 266.6 In-house 18-277 (281) alignment 
Range on Protein: 842-1109
Range on HMM: 18-277/281.0
VAVFQTLPS-GQQFTWEVARRRDNKKRNRYANIIAYDHSRVRL---RDNQESDYINASYlhvkpwrnaegIPSvccVQRPAPFVPCKRPLPVTVADFWQL
.  ...| . |.. | . ... .|...||| ||.|||..||..    .|...|||||..           .|.   .. .. .. .. |.| ....|||.
ieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanf...........vpg...ykgekeyiatqgPvPaslvafWqm

VWQEQVTTIVMLTNIVEVGKTKCHRYWPEGK--ARHGEFDISLHREEVFADYVVRTFIIKKDEGQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRaHY
||...|..|||.|. .| || |||||||...   . |.. .. ..||  | |. |.| .....|..|.|.|..||.|||.|||  .. .|.||..|. ..
vweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevl.kl

TSRNGQVPMLVHCSAGVGRTGAFIAIDAMLERAKKE-KTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEALT
|... ..|...||||||||||..||.| .......| ...|... |. .|..|  |.||  ||.||. |||.|| 
tekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 845-1116 1.4e-80 265.6 In-house 30-287 (315) alignment 
Range on Protein: 845-1116
Range on HMM: 30-287/315.0
FQTLPSGQQFTWEVARRRDNKKRNRYANIIAYDHSRVRL---RDNQESDYINASYLHvkpwrnaeGipsvccVQRPAPFVPCKRPLPVTVADFWQLVWQE
....| || .  .||..  ||..||| ||||||.|||.|     ...|||.||...         |       ...  .. .. |.. .| |||.||..|
yesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfid........G......ynkkrryiaaqgpnvasvkdfwrlvfee

QVTTIVMLTNIVEVGKTKCHRYWPEGKARHGEFDISLHREEVFADYVVRTFIIKKDEgQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAHYTSRNgq
....||||||.||  | |. .|||. |  .|.. ...  |||. .| |||. .  .. . |.|||..|||||| |||....... . |.|. | |.    
digkivmltnlvegekrkaekywpdkkviyGkitvtrkseevnteytvrtlsvvfgd.nirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv..

VPMLVHCSAGVGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEALTCGNTEIE
 ...|||||||||||.||..||.|..|. |. .|..|... .|.||  |.|. .|| |.. |.||.. ||.| | 
gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsia
0047943 (Phosphotyrosine protein) phosphatases II 853-1108 7e-80 263.7 In-house 27-272 (273) alignment 
Range on Protein: 853-1108
Range on HMM: 27-272/273.0
QFTWEVARRRDNKKRNRYANIIAYDHSRVRLrDNQESDYINASYLHVKpwrnaegipsvccvQRPAPFVPCKRPLPVTVADFWQLVWQEQVTTIVMLTNI
..|..||.. .||..||| .|..||||||.| ....||||||||. .               ...  |. .. ||| ||.|||..||...|..|||||..
lltysvallpenkdknrykdilpydhsrvkl.gdggsdyinAsyvdgy..............nlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtel

VEVGKTKCHRYWPEG----KARHGEFDISLHREEVFADYVVRTFIIKK-DEGQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAHYTSRNGQVPMLVH
|| |. ||..|||.     . ..|.| . | .||...||.|||..... . |.||.| .|.||.||| ||| . .|.| | ..|| .. . ... |..||
velgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVH

CSAGVGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEAL
|||||||||.|||.| .|.. .||..||. ..|. .|. |. |.||..|| |.. |.|| |
CsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1160-1365 1.7e-79 261.5 In-house 3-214 (250) alignment 
Range on Protein: 1160-1365
Range on HMM: 3-214/250.0
VGRADYNIKKNRYPSVVPLDSSRVVLSVDG----GDYINASFADAFRKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQEDTLTYPQYWPSKGS
|..   | .||||  ...||||||||  .      |||||||......|.||| ||.||..|. .|| |. ..|.||||||.||.|   ||.|||| ...
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPveka

ETYDHLNVRLMSREKQGKLISRKLAIGQKVSEHE--VVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQCGDKAIVVQCSNGVGRSGTFCAIYSLLERI
|.| .. | |.|.|. . ...||| . ..  ..|  |...... ||||. | . ..||.|.. || ||||.|.. ..||||.||||||.|.||...|||.
ekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerl

KAEQVVDVFQTV
| |.|||||. .
kkekvvdvfkvi
0039614 (Phosphotyrosine protein) phosphatases II 840-1113 7.5e-79 260.6 In-house 33-294 (297) alignment 
Range on Protein: 840-1113
Range on HMM: 33-294/297.0
VLVAVFQTLPSGQQfTWEVARRRDNKKRNRYANIIAYDHSRVRLRDNQE----SDYINASYLHVKPWrnaegipsvccvqRPAPFVPCKRPLPVTVADFW
.| . |..|.| .   ...|..  ||..||| .|..||||||.| .. .    ||||||||. .                ..  |. .. ||| ||.|||
llllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydl.............ltrkfIatqgPlpetvedFw

QLVWQEQVTTIVMLTNIVEVGKtKCHRYWPEGKARHGEFDISLHREEVFADYVVRTFIIKKdEGQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAHY
..||...||.|||||. || |. ||..||||   ..|.| . | ..|. ..|.|||. ... .|.||.| .||||.||| ||| .....| | ..|| ..
rmvweqgvtvivmLtklvelgr.kcaqywpeeggtygdftvtllkvehldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslellleflelvreal

TSRNGQVPMLVHCSAGVGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEALTCGNT
 . ... |.||||||||||||.|||.. |||. .||..||. . |. .|. |. ..||..|| |.. |.|| | ...|
aelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrklt
DSPc_SM00195 853-1107 8.6e-79 259.9 In-house 15-261 (263) alignment 
Range on Protein: 853-1107
Range on HMM: 15-261/263.0
QFTWEVARRRDNKKRNRYANIIAYDHSRVRLRDNQ---ESDYINASYLHVKpwrnaegipsvccvQRPAPFVPCKRPLPVTVADFWQLVWQEQVTTIVML
. . . |..  ||..||| ||. |||.||.| ...   .||||||.|. ..              ...  .. .  ||| ||.|||..||.|.|..||||
pketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga..............nkkkkyIatQgPlpstvedFWrmvweekvkiivml

TNIVEVGKTKCHRYWPEG---KARHGEFDISLHREEVFA-DYVVRTFIIKKDEG-QSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAHYTSRngQVPM
|. .| ||.||.|||||    | ..|.. . | ..|    ....||. ..|..  ..|.| |.||..|||.||| ...||| . |.|. .. .   ..|.
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpi

LVHCSAGVGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEA
.|||||||||||.|..|| .|.. ..||.||| . |. .|..|. |.||..||.|.. |.||.
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 853-1107 8.6e-79 259.9 In-house 15-261 (263) alignment 
Range on Protein: 853-1107
Range on HMM: 15-261/263.0
QFTWEVARRRDNKKRNRYANIIAYDHSRVRLRDNQ---ESDYINASYLHVKpwrnaegipsvccvQRPAPFVPCKRPLPVTVADFWQLVWQEQVTTIVML
. . . |..  ||..||| ||. |||.||.| ...   .||||||.|. ..              ...  .. .  ||| ||.|||..||.|.|..||||
pketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga..............nkkkkyIatQgPlpstvedFWrmvweekvkiivml

TNIVEVGKTKCHRYWPEG---KARHGEFDISLHREEVFA-DYVVRTFIIKKDEG-QSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAHYTSRngQVPM
|. .| ||.||.|||||    | ..|.. . | ..|    ....||. ..|..  ..|.| |.||..|||.||| ...||| . |.|. .. .   ..|.
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpi

LVHCSAGVGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEA
.|||||||||||.|..|| .|.. ..||.||| . |. .|..|. |.||..||.|.. |.||.
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 859-1107 1.7e-77 254.8 In-house 2-239 (239) alignment 
Range on Protein: 859-1107
Range on HMM: 2-239/239.0
ARRRDNKKRNRYANIIAYDHSRVRL---RDNQESDYINASYLhvkpwRNAEGIPSVccvqrpapFVPCKRPLPVTVADFWQLVWQEQVTTIVMLTNIVEV
|..| || .||||||..|||||| |    ..  |||||||||     |. .| |          ..  .  . ..  |||...|||.   ||||| ..| 
akkrvnkaknryanivtydhsrvvleklsndphsdyinasyl.....rdydgspka........yiatqgcveissgdfwrmmwqerrcvivmltglieg

GKTKCHRYWPEGKARHGEFDISLHREEVFADYVVRTFIIKK-DEGQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAhyTSRNGQVPMLVHCSAGVGR
 | |||.|||.  ... .. ..|.. ||||||..|||.. .  . . | | |...| |||||||..||.|||.|||.     |  |  | ..||||||||
hkkkchqywpdstskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitk..dslpgarpwvihcsagvgr

TGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEA
||||. ||||| .|||.||||| |||. .|..|  |.|| .|| |.|.|||||
tgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavlea
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 857-1106 2.2e-77 254.4 In-house 1-239 (239) alignment 
Range on Protein: 857-1106
Range on HMM: 1-239/239.0
EVARRRDNKKRNRYANIIAYDHSRVRL---RDNQESDYINASYLhvkpwRNAEGIPSVccvqrpapFVPCKRPLPVTVADFWQLVWQEQVTTIVMLTNIV
| |..| || .||||||..|||||| |    ..  |||||||||     |. .| |          ..  .  . ..  |||...|||.   ||||| ..
eaakkrvnkaknryanivtydhsrvvleklsndphsdyinasyl.....rdydgspka........yiatqgcveissgdfwrmmwqerrcvivmltgli

EVGKTKCHRYWPEGKARHGEFDISLHREEVFADYVVRTFIIKK-DEGQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAhyTSRNGQVPMLVHCSAGV
|  | |||.|||.  ... .. ..|.. ||||||..|||.. .  . . | | |...| |||||||..||.|||.|||.     |  |  | ..||||||
eghkkkchqywpdstskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitk..dslpgarpwvihcsagv

GRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLE
||||||. ||||| .|||.||||| |||. .|..|  |.|| .|| |.|.||||
grtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
0043336 (Phosphotyrosine protein) phosphatases II 840-1106 7e-77 253.9 In-house 21-275 (278) alignment 
Range on Protein: 840-1106
Range on HMM: 21-275/278.0
VLVAVFQTLPSGQQFTWEVARRRDNKKRNRYANIIAYDHSRVRLRDNQE---SDYINASYLHvkpwrnaegipsvcCVQRPAPFVPCKRPLPVTVADFWQ
.| . |..|.| . .|...|.. .||..||| .|..||||||.| . ..   ||||||||.               . ..|  |. .. ||| ||.|||.
llllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvd..............gynvprkfiatqgPlpetvedFwr

LVWQEQVTTIVMLTNIVEVGKTKCHRYWPEGKARHGEFDISLHREEVFADYVVRTFIIKK-DEGQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAHY
.||...||||||||. || |..||..|||.|  ..|.| . | .||...||.|||. ...  .|.||.|....|..||| ||| . ...| | ..|| ..
mvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreal

TsrNGQVPMLVHCSAGVGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLE
   . . |.||||||||||||.|||.. .||...||..||... |. .|. |. ..||..|| |.. |.||
e..dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
0045450 (Phosphotyrosine protein) phosphatases II 841-1108 1.4e-76 253.5 In-house 29-304 (307) alignment 
Range on Protein: 841-1108
Range on HMM: 29-304/307.0
LVAVFQTLPSGQQF---TWEVARRRDNKKRNRYANIIAYDHSRVRLRDNQ----ESDYINASYLHVKPWRnaegipSVCCVQRPAPFVPCKRPLPVTVAD
| . |..|.| . |   ....|..  ||..||| .|..|||.||.| . .    .||||||||  | ...       . .  ..  |. .. ||| ||.|
llkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvplll......lldgydlkrkfIatqgPlpetved

FWQLVWQEQVTTIVMLTNIVEVGKTKCHRYWPEG--KARHGEFDISLHREEVFADYVVRTFIIKK--DEGQSRQVVQFQYTSWPDKGVPRHATSVLGFRR
||...|...||.|||||. || |. ||..|||.   .  .|.| . | .||. ..|.|||. ..    .|.||.| .|.||.||| ||| .  ..| | .
FwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfie

KVRAHYTSRNGQVPMLVHCSAGVGRTGAFIAIDAMLERAKKEKT---VDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEAL
.||... . ... |.||||||||||||.|||.. ||.. .||.|   ||. . |. .|. |. ..|...|| |.. |.|| |
evrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_PTPRA_pd Subfamily PTPRA 844-1130 5.4e-76 250.6 In-house 37-317 (330) alignment 
Range on Protein: 844-1130
Range on HMM: 37-317/330.0
VFQTLPS-GQQFTWEVARRRDNKKRNRYANIIAYDHSRVRLR---DNQESDYINASYLHvkpwrnaeGipsvccVQRPAPFVPCKRPLPVTVADFWQLVW
 |..||.   | | |.| . .||..||. ||. ||.||| |     ..||||||||...        |       ..   |. .. |.  || |||...|
efnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfid........G......ykekdkfiaaqGPkeetvedfwrmiw

QEQVTTIVMLTNIVEVGKTKCHRYWP-EGKARHGEFDISLHREEVFADYVVRTFIIK-----KDEGQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRA
. . .||||||.. |  ..||..||| ||   .|.  .... |.|  || || |...     ..| .||.| || .||||| ||| ..  .| . .||..
eqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkk

HYTSRNGqvPMLVHCSAGVGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEALTCGNTEIEAGNLQIAMRKRAAV
      |  |. |||||||||||.||..||.||| | |. ||... |. .|..|. |.||. || |.. ..||    |.||...  |.  ..|  . 
lnqqsag..pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhlqklynk
subfamily_PTPN6_pd Subfamily PTPN6 850-1106 9.1e-76 249.8 In-house 40-295 (306) alignment 
Range on Protein: 850-1106
Range on HMM: 40-295/306.0
SGQQFTWEVARRRDNKKRNRYANIIAYDHSRVRLRD--NQESDYINASYLHvKPWRNAEgipsvccvqrpAPFVPCKRPLPVTVADFWQLVWQEQVTTIV
. .... . ... .||..||| ||. .||.|| |..   ..||||||.|.. | ... .           . ..  .  |. ||.|||..||||. . ||
akkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyik.kevkgsd...........ksyiatqgclettvsdFWrmvwqensrviv

MLTNIVEVGKTKCHRYWPEG--KARHGEFDISLHREEVFADYVVRTFIIK--KDEGQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAHYTSRN--GQ
|.|. || || || ||||.   | ..|.  ..  .|.  |||..|.. ..  |.....|.|.|....||||.|||..   || | ..|.... . .   .
mttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaea

VPMLVHCSAGVGRTGAFIAIDAMLERAKKE---KTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLE
 |..||||||.||||.|| ||..|.  .|.     .||.. |...|. |  ..|||.|| ||. |. .
gpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikk
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 854-1106 3.1e-75 247.9 In-house 37-277 (288) alignment 
Range on Protein: 854-1106
Range on HMM: 37-277/288.0
FTWEVARRRDNKKRNRYANIIAYDHSRVRLRD---NQESDYINASYLHVKPWRNAegipsvccvqrpapFVPCKRPLPVTVADFWQLVWQEQVTTIVMLT
 . ...|.  |.|.||| ||..||. ||.|..   ....|||||||....  ...              ..  . ||. || |||.||......||||||
ksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkk..............yiatqgPladtvndfWelvyenktstivmlt

NIVEVGKTKCHRYWPEGKA--RHGEFDISLHREEVFADYVVRTFIIKKdEGQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAHYTSRngQVPMLVHC
..|| |||||..|||...   ..|.... |  ..   |.|.|.....| ... ... |.||..|||.|||. .. .|...|.|    ..   . |..|||
elveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllek.kkteleitqyqylaWpdhgvPeskapllellrqvkvanqad..tgpiivhC

SAGVGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLE
|||||||| |||.||.... ..|...|. . |. .|..| ...||. || |.. ..|.
saGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
Y_phosphatase Protein-tyrosine phosphatase 864-1106 1.2e-74 246.1 Pfam-A 1-235 (235) alignment 
Range on Protein: 864-1106
Range on HMM: 1-235/235.0
NKKRNRYANIIAYDHSRVRLR-DNQESDYINASYLhvkpwrnaegipsvCCVQRPAPFVPCKRPLPVTVADFWQLVWQEQVTTIVMLTNIVEVGKTKCHR
|||.||| .|..||..||.|. ....||||||.|.                 ...  |. .  ||. |..|||..||||.|..|||||. .| |..||..
nkkknRykdilpydktrvklkgsegpsdYInAnyv..............kgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaq

YWP---EGKARHGEFDISLH-REE-VFADYVVRTFIIKKDEGQS--RQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAHYtsRNGQVPMLVHCSAGVGRT
|||   |.. ..|.. . |  .|.   ..|..|.. .||....|  |.| |..||.|||.|||....|.| . |||. .   .. . |..||||||||||
YwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRt

GAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLE
| |.|.|..||....|..||. ..|. .|..|. |.|...||.|.. |.||
gtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 864-1106 1.2e-74 246.1 In-house 1-235 (235) alignment 
Range on Protein: 864-1106
Range on HMM: 1-235/235.0
NKKRNRYANIIAYDHSRVRLR-DNQESDYINASYLhvkpwrnaegipsvCCVQRPAPFVPCKRPLPVTVADFWQLVWQEQVTTIVMLTNIVEVGKTKCHR
|||.||| .|..||..||.|. ....||||||.|.                 ...  |. .  ||. |..|||..||||.|..|||||. .| |..||..
nkkknRykdilpydktrvklkgsegpsdYInAnyv..............kgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaq

YWP---EGKARHGEFDISLH-REE-VFADYVVRTFIIKKDEGQS--RQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAHYtsRNGQVPMLVHCSAGVGRT
|||   |.. ..|.. . |  .|.   ..|..|.. .||....|  |.| |..||.|||.|||....|.| . |||. .   .. . |..||||||||||
YwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRt

GAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLE
| |.|.|..||....|..||. ..|. .|..|. |.|...||.|.. |.||
gtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_PTPRG_pd Subfamily PTPRG 852-1121 1.8e-73 242.7 In-house 35-300 (563) alignment 
Range on Protein: 852-1121
Range on HMM: 35-300/563.0
QQFTWEVARRRDNKKRNRYANIIAYDHSRVRLRDNQE----SDYINASYLHvkpwrnaeGipsvccVQRPAPFVPCKRPLPVTVADFWQLVWQEQVTTIV
.... | .....||..||| ||.|||.|||.|..  .     |||||.|..        |       |.   |.  . ||. |. |||...|...|..||
kdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyid........G......yqkskafiatqgplkdtfddFWrmiWeqnvaiiv

MLTNIVEVGKTKCHRYWPE-GKARHGEFDISLHREEVFADYVVRTFIIKK---DEGQ----SRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAhyTSRN
|.||.|| |. ||..|||. .  . |.. . | .|||.| | |||..||.   ....     ..| |..||.|||.||| |.. || | .|  |  . ..
mitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssa..anka

GQVPMLVHCSAGVGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEALTCGNTEIEAGNLQ
   |..||||||||||| .|..|..|.. ..|..|.... .  .| .|  ..|||.|| |.| |.|||.. ..||. | ...
eaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqve
subfamily_PTPRD_pd Subfamily PTPRD 1155-1365 2.2e-73 242.8 In-house 37-253 (564) alignment 
Range on Protein: 1155-1365
Range on HMM: 37-253/564.0
DENSKVGRADYNIKKNRYPSVVPLDSSRVVLS----VDGGDYINASFADAFRKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQEDTL-TYPQY
 .. .. ... | .||||  .|. |.||||||    ..| ||||||| |..|||.|.| ||.||..|...|| |. .... |||||..|.| .   . .|
qftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkY

WPSKGSETYDHLNVRLMSREKQGKLISRKLAIGQKV--SEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQqQCGDKAIVVQCSNGVGRSGTFCAIY
||.||.|||..| | |.. |.  . . |.. . .|   . .|| . ....|||...| . .|.|||.. |. .. ... . |||.||.||||.|||..| 
WPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfivid

SLLERIKAEQVVDVFQTV
..|||||.|..||..|.|
amlerikeektvDiyqyv
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 839-1116 1.8e-72 238.9 In-house 19-285 (315) alignment 
Range on Protein: 839-1116
Range on HMM: 19-285/315.0
SVLVAVFQTLPSGQQFTWEVARRRDNKKRNRYANIIAYDHSRVRL---RDNQESDYINASYlhvkpwrnaegIPSVCCVQrpaPFVPCKRPLPVTVADFW
...   |. ||  . .   ||| ..| |.||| ||. .|..||.|    |. .||||||||           |.|| . .    ..  . ||. .| |||
alfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasy...........iksvdddk...ayiasqgPlkasvddfw

QLVWQEQVTTIVMLTNIVEVGKTKCHRYWPE---GKARHGEFDISLHREEVFADYVVRTFIIKKDEgQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVR
..|.||.||||||.|.  |  | || .|||.     .. |.. ..|   |  .| |.| ....| | .||.| |||.| ||||||.....|.| . ..|.
rmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkse.esrtvtqfqftewPdkGvdkqtssllklikevk

AHytSRNGQVPMLVHCSAGVGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEALTCGNTEIE
|    .. . ..|||||||||||| .|.|| .....|....||. |.|. .|..|  ..|||..|||.. |||| |   || | 
ad..ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlil
subfamily_PTPN3_pd Subfamily PTPN3 852-1107 2.1e-72 238.4 In-house 29-274 (280) alignment 
Range on Protein: 852-1107
Range on HMM: 29-274/280.0
QQFTWEVARRRDNKKRNRYANIIAYDHSRVRLRDNQEsDYINASYLHVKpwrnaegIPSVCCVQRpapFVPCKRPLPVTVADFWQLVWQEQVTTIVMLTN
.. . ..||. .| ..||| .|..||. ||.|....  |||||.|. ..       ||| . |.|   .. .. ||. |..||||.||......|||||.
pglaisaarkpenlsknryrdilpydatrvklkeset.dyinanyvnme.......ipstglvnr...yiatqGPlaktatdfWqmvweqksslivmltt

IVEVGKTKCHRYWPEG--KARHGEFDISLHREEVFADYVVRTFIIKKDE-GQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAHYTSRngQVPMLVHC
.|| |..|||.||||   . ..|||.. ...|.    ||.| ...|. |  ..|...|.||..|||.||| .....| | ..||.  ...  . |..|||
lverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgk..eePvvvhC

SAGVGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEA
|||.|||| .|...  |    ... | . . |  ||. | ...||..|| ||  |.|..
saGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 840-1117 1.5e-71 236.1 In-house 19-285 (515) alignment 
Range on Protein: 840-1117
Range on HMM: 19-285/515.0
VLVAVFQTLPSGQQFTWEVARRRDNKKRNRYANIIAYDHSRVRL---RDNQESDYINASYlhvkpwrnaegIPSVCCVQrpaPFVPCKRPLPVTVADFWQ
..   |. ||  . .   ||.   | |.||| ||. || .||.|    || .|||.||||           |||. . .    ..  . |.. .| |||.
lfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasy...........ipsfdndk...ayiasqgPnkasvddfWr

LVWQEQVTTIVMLTNIVEVGKTKCHRYWPE---GKARHGEFDISLHREEVFADYVVRTFIIKKDEGqSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRA
||.||.||||.|.|.  |  | || .|||.      . |.. ..|   |  .. . |.. . |..  || | ||..| |||||||.|..|.| . ..|.|
lvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd.srtvtqfhfteWPdkGvpkhtssllklikevka

HYTSRNgqVPMLVHCSAGVGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEALTCGNTEIEA
     .   |...|||||||||| .|.|| .. .||. ..||. |.|...|..|  ..||..||||.. |||| |   || |  
dhgqyt..hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipv
0040439 (Phosphotyrosine protein) phosphatases II 855-1108 2.4e-71 235.5 In-house 2-246 (249) alignment 
Range on Protein: 855-1108
Range on HMM: 2-246/249.0
TWEVARRRDNKKRNRYANIIAYDHSRVRLRDNQE---SDYINASYLhvkpwrnaegipsvCCVQRPAPFVPCKRPLPVTVADFWQLVWQEQVTTIVMLTN
...||..  ||..||| .|..||||||.| . ..   ||||||||.               . ...  |. .. ||| ||.|||...|....|.|||||.
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyi..............dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLts

IVEVGKTKCHRYWP-EGKARHGEFDISLHREEVFADYVVRTFIIKK-DEGQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAHYTSRNGQVPMLVHCS
 || |. ||..||| .|   .|.| . | ..||..||.|||. ...  .|.||.| ..|||.||| ||| .  ..| | ..|| .... . . |.|||||
lvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCs

AGVGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEAL
|||||||.|||.. |||. .||..||. ..|. .|. |. ..|...|| |.. |.|| |
aGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 863-1106 2.5e-71 234.7 In-house 2-237 (237) alignment 
Range on Protein: 863-1106
Range on HMM: 2-237/237.0
DNKKRNRYANIIAYDHSRVRLRDN-QESDYINASYLhvkpwRNAEGIPSVccvqrpapFVPCKRPLPVTVADFWQLVWQEQVTTIVMLTNIVEVGKTKCH
.|| .|||.||.||||||| |. .  .||||||.||     .. .| |          .. .. ||  .  ||||.||||. . ||||| ..|  . |||
enkiknrygnivaydhsrvvlkgagsgsdyinatyl.....kgfdgtpkk........yiaaqgplesscddfwqmvwqekcsvivmltgliegnelkch

RYWPEGK--ARHGEFDISLHREEVFADYVVRTFIIKKDEG--QSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAHYTSRNGQVPMLVHCSAGVGRTGA
.|||. .  | .| . .||...| |.|| ||.... |     . | . |.|.|||||.|||......| ||...  .    .   | ..|||||||||| 
kywpstdqpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgi

FIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLE
|. ||||| .||..| |||.|||  . ..|  .|||.||| |.| ..||
flvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
0045098 (Phosphotyrosine protein) phosphatases II 844-1111 5e-70 231.3 In-house 13-275 (278) alignment 
Range on Protein: 844-1111
Range on HMM: 13-275/278.0
VFQTLPSGQQFTWEVARRRDNKKRNRYANIIAYDHSRVRlrdnqesDYINASYLHVKPWrnaegipsvccvqrpaPFVPCKRPLPVTVADFWQLVWQEQV
 .. |. |.  ....| ...|...||| .|..||||||.       |||||||... |                  |. .  ||| ||||||...|....
fefllllgipseitpalylgnldknRykdilpydhsrVk.......dYINAsyidgypk................kfIatqgPlpstvadfwrmlwelgi

TTIVMLTNIVEVGKTKCHRYWPEGK-ARHGEFDISLHREEVFADYVVRTFIIKK-----DEGQSRQVVQFQYTSWPDKGVPRHA--TSVLGFRRKVRAHY
|.|||||. || |. ||..|||||.  ..|.| . |  |||. ||..||...        ...|| | ...|..||| ||| .   .|.| . . .|...
tvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefireal

T-----------SRNGQVPMLVHCSAGVGRTGAFIAIDAMLERAkkEKTVDIHNYVNVMRNNRCT-MIQTEDQYAFVHFAVLEALTCG
              ... |.||||||||||||...|.. |||.   |..||. ..|. .|. |.  ..|...|| |.. ..|| | .|
kllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg
subfamily_PTPN12_pd Subfamily PTPN12 852-1108 1.4e-69 229.2 In-house 28-277 (290) alignment 
Range on Protein: 852-1108
Range on HMM: 28-277/290.0
QQFTWEVARRRDNKKRNRYANIIAYDHSRVRLRD---NQESDYINASYLHVkpwrnaegipsvccVQRPAPFVPCKRPLPVTVADFWQLVWQEQVTTIVM
.... |....  |.|.||| .|. ||.||| |.    ...||||||....               |. .  ..  . ||| |. |||...|. .|. .||
kvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikg..............vegkleyiaaqgPLpktlddfWrmiweknveivvm

LTNIVEVGKTKCHRYWPEG---KARHGEFDISLHREEVFA-DYVVRTFIIKKDeGQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAHYTsrNGQVPM
. ..||.||.||.|||||    . ..||| ..|..|. .  |...||. .... ..||.| ||.||.|||.|||. |.|.| . ..|| . .  . ..|.
aCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq.kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..sedaPl

LVHCSAGVGRTGAFIAIDAMLERAKKEK---TVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEAL
.|||||||||||. |||| . |  |.||   ..|... |  .|..| ...||..|| .|. ||.| .
vvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 840-1118 4.1e-69 228.0 In-house 27-294 (297) alignment 
Range on Protein: 840-1118
Range on HMM: 27-294/297.0
VLVAVFQTLPSGQQFTWEVARRRDNKKRNRYANIIAYDHSRVRLRD--NQ-ESDYINASYLHVKPWrnaegipsvccvqrpaPFVPCKRPLPVTVADFWQ
|    |. ||. . ..  ||... | ...||.||. || |||.|.   .. .|||.|||....                    ..  ..| . ||||||.
vfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh................rlittqmPmkatvadfWa

LVWQEQVTTIVMLTNIVEVGKtKCHRYWPE-GKARHGEFDISLHREEVFADYVVRTFIIKKDEGQSRQVV-QFQYTSWPDKGVPR--HATSVLGFRRKVR
.|..|||.|||||..  |  | || |||.. | .  |.  . |.  .    .. |.. ..|.. ..|.|| |.|...|||| |.|  .|.|.| .   ||
mvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevr

AHYTSRNGQvPMLVHCSAGVGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEALTCGNTEIEAG
 .. ...   |.||||.||||||| ...|| .. .||.||.||| ..|. .|..|  ..||..||.||. |||||| . .|.|.| 
kdfsqnaeg.PllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqas
0042113 (Phosphotyrosine protein) phosphatases II 857-1107 5.6e-69 227.5 In-house 2-242 (245) alignment 
Range on Protein: 857-1107
Range on HMM: 2-242/245.0
EVARRRDNKKRNRYANIIAYDHSRVRLRDNQE---SDYINASYLhvkpwrnaegipsvCCVQRPAPFVPCKRPLPVTVADFWQLVWQEQVTTIVMLTNIV
.||..  ||..||| .|..|||.||.| . ..   ||||||||                . ...  |  .  ||| ||.|||...|....|||||||. .
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyv..............dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteee

EVGKTKCHRYWP-EGKARHGEFDISLHREEVFADYVVRTFIIKK-DEGQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAHYTSrNGQVPMLVHCSAG
| |. ||..||| ... ..|.| . | .||...||.|||. ...  ...||.|....|..||| ||| .  ..| | . || .. . ... |.|||||||
elgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaG

VGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEA
|||||.|||.. |||...||..|.. . |  .|. |. ..||..|| |.. |.|| 
vgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
0037934 (Phosphotyrosine protein) phosphatases II 856-1106 2.9e-68 225.3 In-house 2-240 (243) alignment 
Range on Protein: 856-1106
Range on HMM: 2-240/243.0
WEVARRRDNKKRNRYANIIAYDHSRVRLrDNqeSDYINASYLHVKPwrnaegipsvccvqrpaPFVPCKRPLPVTVAD----FWQLVWQEQVTTIVMLTN
. .|..  |...||| .|..||||||.| ..  ||||||..  | |                  .  .  ||| ||.|    ||...|....|.|||||.
fsiallpenlsknrysdilpydhsrvkl.eg..sdyinanliyvtp.................rliatqgPlpetveddlasfwrmlwelgitvivmlte

IVEVGKTKCHRYWPeGKARHGEFDISLHREEVFADYVVRTFIIKK--DEGQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAHYTS------RNGQVP
 || |. ||..||| |. ..|.| . |  ||...||.|||. ..    ....|.|....|..||| ||| . ...| | ..||... .      .... |
lvElgrekcaqywp.gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggp

MLVHCSAGVGRTGAFIAIDAMLERAkkekTVDIHNYVNVMRNNRCT-MIQTEDQYAFVHFAVLE
.||||||||||||..||.. ||..     .||. ..|. .|. |.  ..||..|| |.. |.||
vlVHCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Ptp69D_pd Subfamily Ptp69D 845-1123 3e-68 225.2 In-house 28-301 (307) alignment 
Range on Protein: 845-1123
Range on HMM: 28-301/307.0
FQTLP-SGQQFTWEVARRRDNKKRNRYANIIAYDHSRVRLR---DNQESDYINASYlhVKPWRNAEgipSvccvqrpapFVPCKRPLPVTVADFWQLVWQ
...|. .  . . .|. . .|. .||| .|.|.|. ||.|.    ...|||||||.  .| ... .   .         |.  . |.  |. |||.....
yekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasf..ikgykekk...k.........fiaaqdPveatigDfWRmiae

EQVTTIVMLTNIVEVGKTKCHRYWP-EGKARHGEFDISLHREEVFADYVVRTFIIKKDE------GQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRA
 .||.||||.|. |  . ||..||| | . ..|.  . | .||   ||. |.. . | .       .||.|||..||.|.|  ||..|...| . ..|| 
qevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvre

HYTSRngQVPMLVHCSAGVGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEALTCGNTEIEAGNLQIA
.|     . |..|||||||||.| |.|.| .|.. |.|..||| . |  .|..|  ..|  .|| |.. |.|.  . |.|...  .|. |
lykln..rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddleda
0051299 (Phosphotyrosine protein) phosphatases II 1123-1365 3.1e-68 225.7 In-house 13-258 (288) alignment 
Range on Protein: 1123-1365
Range on HMM: 13-258/288.0
AMRKRAavkpTQNLSGYALEYQRLLAVSSQiedENSKVGRADYNIKKNRYPSVVPLDSSRVVLSV----DGGDYINASFADAFRKRNAFILTQAPLEHTM
...|.       .|.|.. |...||..  .    . ....   |..||||....|.|.|||.|||    .|.||||||. | ... ..||.||.||..|.
lvlkll....angltglleefeellsllpd...ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntv

AEFWHMICQYKIGTIVMLNNLQEDT-LTYPQYWPSKGSETYDHLNVRLMSREKQGKLISRKLAIG------QKVSEHEVVHIQHIEWPDKCAPVNHQSVL
..||.|. .... .||||..|.|.   ...||||..||.||... |.|.| |.... . |.| .       ..  ...| |.... ||| ..| . ...|
edFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspelll

DLVSWVQLSQQqCGDKAIVVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTV
|.. .|. ...  |.. .|| ||.||||.|||.|.. |||....|..|||...|
dflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleav
0050432 (Phosphotyrosine protein) phosphatases II 1131-1365 8.2e-68 224.3 In-house 36-271 (308) alignment 
Range on Protein: 1131-1365
Range on HMM: 36-271/308.0
KPTQNLSGYALEYQRLLAVSSqieDENSKVGRADYNIKKNRYPSVVPLDSSRVVLSvDGGDYINASFADAF--RKRNAFILTQAPLEHTMAEFWHMICQY
..  .|...  |...||.|     ... .|..   |..||||....|.|.|||.|. .| ||||||. | .  .....||.||.||..|.. ||.|. ..
ekaldlglleeefeellsvkp...lleysvallpenkdkNrykdilpydhsRVkld.egsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweq

KIGTIVMLNNLQEDT-LTYPQYWPSK---GSETYDHLNVRLMSREKQGKLISRKLAIGQ--KVSEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQq
.. .||||..|.|.   ...||||..   ||..|... |.|.| |...  . |.| .    .  ...| |.... ||| ..| . ...||.. .|. |. 
nvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl.

qcGDKAIVVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTV
  ... ||| ||.||||.|||.|.. |||....|. ||||..|
..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeav
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 853-1115 4.1e-67 221.2 In-house 38-285 (287) alignment 
Range on Protein: 853-1115
Range on HMM: 38-285/287.0
QFTWEVARrrDNKKRNRYANIIAYDHSRVRLRdNQESDYINASYLHvkpwrnaeGipsvccVQRPAPFVPCKRPLPVTVADFWQLVWQEQVTTIVMLTNI
. | ..|   .||..||...|. .|  || |. ... |||||...         |       .    |. .. |.  |. .||.|.....||.||||.. 
evthnias..qnkdknRltqilvpdnyrvllk.gehpdyinavfid........g......ykekkafiiaesPmfntarnfWkliddrnvtaivmlcqe

VEVGKTKCHRYWPEGK-ARHGEFDISLHREEVFADYVVRTFIIKKDE--GQSRQVVQFQYTSWPDKG-VPRHATSVLGFRRKVRAHYtsRNGQVPMLVHC
 |  . .|..||||.|    ||. |.|  ||| |.|..|.. .|...  |. .||.|.|.|.|...| |....|..| . .......  ..|. ...|||
kendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqr..krgntsivvhC

SAGVGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEALTCGNTEI
|..|||.. |.|..  ....|.| ..|. . .. .|  . ...|| .|| |.  .||| |....|  
sdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetys
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 842-1120 3.3e-66 218.6 In-house 26-300 (325) alignment 
Range on Protein: 842-1120
Range on HMM: 26-300/325.0
VAVFQTLPSGQQFTWEVARRRDNKKRNRYANIIAYDHSRVRL---RDNQESDYINASYLHVKPWRNAegipsvccvqrpapFVPCKRPLPVTVADFWQLV
   |. ||| .  . .|| . .||..||. |..|.|.||| |   .|. .|||||||||.    ..               |. .. ||. |. |.|.||
ahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdv..............flaaqaPltatindlWrlv

--WQeqvTTIVMLTNIVEVGKTKCHRYWPEG---KARHGEFDISLHREEVFADYVVRTFIIKKDE-GQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVR
  |.   ...|...|... || .|  |||.      . | ....|   | ..||| | . .|. . |..| | |||. ||.| ||... .... . . | 
ldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvk

AHY---T-SRNGQVPMLVHCSAGVGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEALTCGNTEIEAGNL
|     |   ..  |.||||||||||||.||.. ..|..  .|  ||| ..|. .|..| .|..| ||| ... |. ||. .|||..   ..
avservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssf
subfamily_PTPN13_pd Subfamily PTPN13 856-1109 4.2e-66 218.0 In-house 29-270 (273) alignment 
Range on Protein: 856-1109
Range on HMM: 29-270/273.0
WEVARRRDNKKRNRYANIIAYDHSRVRLRDNQEsdYINASYLHVKPwrnaegipsvccVQRPAPFVPCKRPLPVTVADFWQLVWQEQVTTIVMLTNIVEV
 ||.....||..||| |.. ||..||.| |.    |||||...|.              .    .. |. ||| ||.||||.||. ... |.|.|. .| 
cevgkkkenkdknryrnvlPydetrvklgdegg..yinaslikvpv............gkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekek

GKTKCHRYWPEGKARH----GEFDISLHREEVFADYVVRTFIIKK-DEGQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAHYTsrnGQVPMLVHCSA
|| |||||||| | ..    . ....| . .   ..|||.. .|. . |.||.|.......||| |||..|...| | ..||   |    . |..|||||
gkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt...dagPivvhcsa

GVGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEALT
|.||.|..|.||..|.  ...| .|... |. .|. | ...||.||| ||. |.||.|.
GiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_PTPN9_pd Subfamily PTPN9 855-1106 9.1e-66 216.9 In-house 33-288 (297) alignment 
Range on Protein: 855-1106
Range on HMM: 33-288/297.0
TWEVARRRDNKKRNRYANIIAYDHSRVRLR---DNQESDYINASYLHvkpwrnaeGipsvccVQRPAPFVPCKRPLPVTVADFWQLVWQEQVTTIVMLTN
| .... | | ..|||.... ||..|| |    ....||||||...         |       ...  |.  . ||. || |||..||...| .||| | 
tflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvd........G......ykqkkafiatqGplkktvsdfWrmvWeqevlvivmttr

IVEVGKTKCHRYWP---EGKARHGEFDISLHREEVFADYVVRTFIIK-KDEGQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAHYTS----------
.|| |. || .|||   |  |..|.. .|    |.  ||.||.. ||  ....||.|. ||..|||| |||. |.|.| ...||| . ..          
vvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewk

-RNGQVPMLVHCSAGVGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLE
 .  . |..||||||.||||.||..|  |.| ... |||. . |. .|. |  .|||..||.| ..||||
ghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 845-1112 1.3e-64 212.9 In-house 26-287 (290) alignment 
Range on Protein: 845-1112
Range on HMM: 26-287/290.0
FQTLPSG-QQFTWEVARRRDNKKRNRYANIIAYDHSRVRLRDNQES-----DYINASYlhVKPWRNAEgipsvccvqrpaPFVPCKRPLPVTVADFWQLV
|..| || ...| .|.   .||..||.|||. ||  |. ||. ..      .||||.|  .| .....             ..  . |.. |..|||.|.
fkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcy..ikgykekk............qyiatqgpvsntlvdFWkli

WQEQVTTIVMLTNIVEVGKTKCHRYWPEG-KARHGEFDISLHREEVFADYVVRTFIIKKDEG--QSRQVVQFQYTSWPDKG-VPRHATSVLGFRRKVRAH
|||.|| |||||||.| ||.||. |||.   .. ||| | |. ||.. .|. |.. .|...   ....|.|.| |.|...| |. ..|..| ... .. .
wqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktq

YtsRNGQVPMLVHCSAGVGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEALTCGN
.  ..|. ...||||..|||.. |.|..  ....|.|  .|. . .. .|  .  ..||..|| ...  ||..|.. .
r..krgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfe
0046845 (Phosphotyrosine protein) phosphatases II 1141-1365 2.4e-64 212.8 In-house 4-246 (284) alignment 
Range on Protein: 1141-1365
Range on HMM: 4-246/284.0
LEYQRLLAVSSQIEdENSKVGRADYNIKKNRYPSVVPLDSSRVVLSV-----DGGDYINASFADAF-----RKRNAFILTQAPLEHTMAEFWHMICQYKI
 |...|| .   ..  . .|...  |..||||....|.|.|||.|..     ...||||||. | .     .....||.||.||..|...||.|. ....
eefeellsltvkll.lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnv

GTIVMLNNLQEDT-LTYPQYWPSKG-SETYDHLNVRLMSREKQGKLISRKLAIGQ---KVSEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQ-C
 .||||..| |.    ..||||..| . ||... |.|.|.|...  . |.| .     .  ...| |.....||| ..| . ...|... .|. ....  
rvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlp

GDKAIVVQCSNGVGRSGTFCAIYSLLERIKAEQ---VVDVFQTV
|.. ||| ||.||||.|||.|.. |||....|.   .|||...|
gggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleav
0047943 (Phosphotyrosine protein) phosphatases II 1132-1365 2.6e-64 212.7 In-house 7-244 (273) alignment 
Range on Protein: 1132-1365
Range on HMM: 7-244/273.0
PTQNLSGYALEYQRLLAVSSqieDENSKVGRADYNIKKNRYPSVVPLDSSRVVLSVDGGDYINASFADAFRKRNAFILTQAPLEHTMAEFWHMICQYKIG
.  .|.....|...|| .     . . .|..   |..||||....|.|.|||.|. .| ||||||. | ... ..||.||.||..|...||.|. .... 
kllgltllleefelllslkp...lltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvr

TIVMLNNLQED-TLTYPQYWPSKG---SETYDHLNVRLMSREKQGKLISRKLAIGQ--KVSEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQC-
.||||..|.|.   ...||||..|   |.||... |.|.| |. .  . |.| .       ...| |... .||| ..| . .|.|... .|.  .... 
viVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealp

GDKAIVVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTV
... .|| ||.||||.|||.|.. ||.....|. |||...|
sngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleav
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 862-1118 1e-63 210.6 In-house 59-301 (319) alignment 
Range on Protein: 862-1118
Range on HMM: 59-301/319.0
RDNKKRNRYANIIAYDHSRVRLRD---NQESDYINASYlhvkpwrnaegipsVCCVQRPAPFVPCKRPLPVTVADFWQLVWQEQVTTIVMLTnivevgKT
 .|| .||. ||.|.|...|.|.     . |||||||.              |   ||.  .. .. ||. |.||||...|. ...|||.||      | 
dqnkdknriinilafdknvvklerliGeefsdyinasf..............vtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kd

KCHRYWP-EGKARHGEFDISLHREEVFADYVVRTFIIKK--DEGQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAHYTSRNGQVPMLVHCSAGVGRT
|| .||| ... ....|.....  |  |.|||| . . .   | . |.. || .  |||.||| ... .. . .|||   .  |.. ...||||||||||
kcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrt

GAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEALTCGNTEIEAG
|..|..|..|.| |.|| ||..|.|. .|..| |..|   || |.. |.||    |....   
Gvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvamp
0040438 (Phosphotyrosine protein) phosphatases II 1152-1365 1.3e-63 210.5 In-house 30-248 (317) alignment 
Range on Protein: 1152-1365
Range on HMM: 30-248/317.0
QIEDeNSKVGRADYNIKKNRYPSVVPLDSSRVVLSVDGG----DYINASFADAFRKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQEDT-LTY
.. | . .|..   |..|||||...|.|.|||.||..||    ||||||. | ......||.||.||..|.. ||.|. ......||||..| |.   ..
lkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekc

PQYWPSKGSETYDHLNVRLMSREKQGKLISRKLAIG--QKVSEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQqCGDKAIVVQCSNGVGRSGTFC
 ||||.... ||... |.|.| |. .  . |.| .   ..  ...| |.... ||| ..| .....||....|. ...  ... ..| ||.||||.|||.
aqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfi

AIYSLLERIKAEQVVDVFQTV
|.| .||... |. |||...|
aaylmleqlekeggvdveeav
0039614 (Phosphotyrosine protein) phosphatases II 1134-1365 1.5e-63 210.4 In-house 29-261 (297) alignment 
Range on Protein: 1134-1365
Range on HMM: 29-261/297.0
QNLSGYALEYQRLLAVSSqieDenSKVGRADYNIKKNRYPSVVPLDSSRVVLSVDG-----GDYINASFADAFRK-RNAFILTQAPLEHTMAEFWHMICQ
 . ... ||...|| .     |   ....   |..||||....|.|.|||.|.. .      ||||||. | ...  ..||.||.||..|.. ||.|. .
nsktllllefeellslkp...d..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvwe

YKIGTIVMLNNLQEDTLTYPQYWPSKGSeTYDHLNVRLMSREKQGKLISRKLAIGQKVSEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQC-GD
... .||||..| |.  ...||||..|. ||... |.|.. |. .  . |.| .  .  ...| |.|.. ||| ..| .....|... .|.  .... ..
qgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkg

KAIVVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTV
. ..| ||.||||.|||.|.| .||... |. |||...|
gpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleav
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 862-1119 5.4e-63 208.1 In-house 23-266 (284) alignment 
Range on Protein: 862-1119
Range on HMM: 23-266/284.0
RDNKKRNRYANIIAYDHSRVRLRD---NQESDYINASYlhvkpwrnaegipsVCCVQRPAPFVPCKRPLPVTVADFWQLVWQEQVTTIVMLTnivevgKT
 .|| .||. .|.|.|...|.|.    .. |||||||.              .   ||.  .. .. ||. |.||||...|. ...|||.||      | 
dqnkdknrighilafdknvvklerliGeefsdyinasf..............itGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kd

KCHRYWP-EGKARHGEFDISLHREEVFADYVVRTFIIKK--DEGQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAHYTSRNGQVPMLVHCSAGVGRT
|| .||| ... ....|.....  |  ..|||| . . .   | . |.. || .  |||.||| ... .. . .|||   .  |.. ...||||||||||
kcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrt

GAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEALTCGNTEIEAGN
|..|..|..|.| |.|| ||..|.|. .|..| |..|   || |.. |.||    |....   .
gvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpd
0036941 (Phosphotyrosine protein) phosphatases II 1137-1365 8.5e-63 207.7 In-house 13-249 (297) alignment 
Range on Protein: 1137-1365
Range on HMM: 13-249/297.0
SGYALEYQRLlavSSQIEDENSKVGRADYNIKKNRYPSVVPLDSSRVVLSVDGGDYINASFADAFRKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVML
...  |...|    . . . . .|..   |..||||....|.|..||.|. .| ||||||. | ..  ..||.||.||..|...||.|. .... .||||
alllkefeel...lpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvml

NNLQED-TLTYPQYWPSK--GSETYDHLNVRLMSREK--QGKLISRKLAIGQ--KVSEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQC-GDKA
..| |.   ...||||..  .| ||... |.|.| |.   .  . |.| .    .  ...| |.... ||| ..| ...|.||.. .|.  ...  ... 
telvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggp

IVVQCSNGVGRSGTFCAIYSLLERIK---AEQVVDVFQTV
..| ||.||||||||.|.. .|....    |. ||....|
vlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileav
0045450 (Phosphotyrosine protein) phosphatases II 1130-1365 1.3e-62 207.7 In-house 20-276 (307) alignment 
Range on Protein: 1130-1365
Range on HMM: 20-276/307.0
VKPTQNLSGYALEYQRLLAVSSQIeDENSKVGRADYNIKKNRYPSVVPLDSSRVVLSV-----DGGDYINASFA--------DAFRKRNAFILTQAPLEH
...  .|.|.. |...|| |  ..   . ....   |..||||....|.|..||.||.     ...||||||.         | ... ..||.||.||..
lllldfltgllkefekllsvtvfl.lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpe

TMAEFWHMICQYKIGTIVMLNNLQEDTL-TYPQYWPSKGSE-TYDHLNVRLMSREKQGKLISRKLAIG---QKVSEHEVVHIQHIEWPDKCAPVNHQSVL
|...||.|. ......||||..| |..   ..||||..|.| ||... |.|.| |...... |.| .    ..  ...| |.....||| ..| . ...|
tvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeell

DLVSWVQLSQQQC-GDKAIVVQCSNGVGRSGTFCAIYSLLERIKAEQV---VDVFQTV
|..  |.  .... ... ..| || ||||.|||.|.| .|.....|..   ||....|
dfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleav
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 855-1121 1.3e-60 199.7 In-house 24-279 (283) alignment 
Range on Protein: 855-1121
Range on HMM: 24-279/283.0
TWEVARRRDNKKRNRYANIIAYDHSRVRLRDNQEsDYINASYLHVkpwrnaegipsVCCVQRPAPFVPCKRPLPVTVADFWQLVWQEQVTTIVMLTNIVE
  ..|  ..||. ||. .|...|  ||.|. . . |||||... |               ..   .. .. ||  || |||..|..|..|.|||||.. |
dadiasadenkrknrnqeivpadqwrvelksesr.dyinavfipv...........sksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqe

VGKTKCHRYWP-EGKARHGEFDISLHREEVFADYVVRTFIIKKD-EGQSRQ-VVQFQYTSWPDKGVPRHATSVLGFRrKVRAHYTSrNGQVPMLVHCSAG
  . || .||| .|   .||| ..|..|     .... ......   .|   .  .|.  | . |      |.. |  ||..  |  . . |..||||.|
dlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfn.kvislqte.skkgPivvhCstg

VGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEALTCGNTEIEAGNLQ
.|||..|||. | .. |. |  ||. . |..||..| ...|| ||| .|| .|||   ||.|.| | .||
iGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdlq
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 862-1106 1.6e-60 199.6 In-house 26-266 (274) alignment 
Range on Protein: 862-1106
Range on HMM: 26-266/274.0
RDNKKRNRYANIIAYDHSRVRLRD----NQESDYINASYLHvkpwrnaeGIPsvccvQRPAPFVPCKRPLPVTVADFWQLVWQEQVTTIVMLTNIVEVGK
  ....||| .|.  ..||| |.     ...|.|||| |..        |       ..   .|  . ||| ||||||....||.|. |||||.. |  .
fgsqtknryktilPnensrvllesessededssyinanyik........Gyd.....eeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeane

TKCHRYWPEGKA-----RHGEFDISLHREEVFADYVVRTFIIKKDEGqSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAHYTSRNGQ-VPMLVHCSAG
.||..|.|. .      |.|...|  .      || ||....|. |  .|.|. . ||.|||. .|..|...| . ..|.   ...| .  |..||||||
qkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler.ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaG

VGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLE
.||||.||||.  . . ..|..||. . |  .| .|  |.||..|| ..| |. .
iGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl
0043336 (Phosphotyrosine protein) phosphatases II 1135-1365 2.4e-60 199.7 In-house 18-249 (278) alignment 
Range on Protein: 1135-1365
Range on HMM: 18-249/278.0
NLSGYALEYQRLLAVSSqiedENSKVGRADYNIKKNRYPSVVPLDSSRVVLSVDG----GDYINASFADAFRKRNAFILTQAPLEHTMAEFWHMICQYKI
. ... ||...|| .      .. ....   |..||||....|.|.|||.||..|     ||||||. | ... ..||.||.||..|.. ||.|. ....
lktllllefeellsfkl....dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgv

GTIVMLNNLQEDT-LTYPQYWPsKGSETYDHLNVRLMSREKQGKLISRKLAIG--QKVSEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQqCGDK
 |||||..| |.   .. |||| .||.||... |.|.. |...  . |.| .   ..  ...|.|.... ||| ..| . ...||.. .|.  ..   ..
ttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsng

AIVVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTV
...| ||.||||.|||.|.| |||... |. ||....|
pvlVHCsaGvgRTGtfialyllleqlekeggvdleeav
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1140-1365 5.7e-60 198.0 In-house 23-252 (318) alignment 
Range on Protein: 1140-1365
Range on HMM: 23-252/318.0
ALEYQRLLAVSSQIEDENSkvgRADYNIKKNRYPSVVPLDSSRVVLS----VDGGDYINASFADAFRKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVM
  ||.||  .....   .|     . | .||||  ... |..|| |.    . | |||||.. | .|...|.| .|||| .|. .|| |. . .  .|||
seeyerlsrseetvtslks...lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivm

LNNLQEDT-LTYPQYWPSKGSETYDHLNVRLMSREKQGKLISRKLAIGQKVSE--HEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQCGDKAIVVQ
| ...| .     .|||||||..|..| | |... . .... |.. . .. .|   .|   .. .|||.  | .  |.||||  |.  ||..| ..||| 
ltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvh

CSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTV
|| |||| |.|.|. .||||||||..|||||||
CsaGvGrtGvfiavdillerikaealvDvfqtv
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1157-1365 8.3e-60 197.5 In-house 39-255 (319) alignment 
Range on Protein: 1157-1365
Range on HMM: 39-255/319.0
NSKVGRADYNIKKNRYPSVVPLDSSRVVLS----VDGGDYINASFADAFRKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQEDT-LTYPQYWP
. .    . | |||||. ... | .|||||    |.| ||||||| |....|..|| ||||||.|. .|| |. .... ..|||..|.|   . . .|||
tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywp

SKGSETYDHLNVRLMSREKQGKLISRKLAIGQKVSEH---EVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQCGDKAIVVQCSNGVGRSGTFCAIYS
..  |.| .| | | ..|.. ..| ||| . .| ||    ||.| |. ||||.  | . .|.|||.  .. |...  .. ||| ||.|||| |||...  
eenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivlda

LLERIKAEQVVDVFQTV
 |||.| |.|.|||.||
mlervkeegvlDvfstv
DSPc_SM00195 1144-1365 1.2e-59 197.2 In-house 7-234 (263) alignment 
Range on Protein: 1144-1365
Range on HMM: 7-234/263.0
QRLLAVSSQIedeNSKVGRADYNIKKNRYPSVVPLDSSRVVLSVD----GGDYINASFADAFRKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNL
..|..  |.    ... .. . | .||||  ..| |..|| |. .    | |||||.. .  .|....|.||.||..|...||.|. . |. .||||.. 
ekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmltee

QE-DTLTYPQYWPSK--GSETYDHLNVRLMSREKQG-KLISRKLAIGQKV--SEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQCgDKAIVVQC
.| .  .  .|||..  |.||.....| |.. ||.  ..| |.| . ..    ...| ..|. .|||. .| ...|||.|.. |. |...  .. |||.|
eengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhC

SNGVGRSGTFCAIYSLLERIKAEQVVDVFQTV
|.||||.|||..| ..|.....|. ||.|..|
saGvgRtgtfvtidiilskleeekkvdifeiv
PTPc_SM00194 1144-1365 1.2e-59 197.2 In-house 7-234 (263) alignment 
Range on Protein: 1144-1365
Range on HMM: 7-234/263.0
QRLLAVSSQIedeNSKVGRADYNIKKNRYPSVVPLDSSRVVLSVD----GGDYINASFADAFRKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNL
..|..  |.    ... .. . | .||||  ..| |..|| |. .    | |||||.. .  .|....|.||.||..|...||.|. . |. .||||.. 
ekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmltee

QE-DTLTYPQYWPSK--GSETYDHLNVRLMSREKQG-KLISRKLAIGQKV--SEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQCgDKAIVVQC
.| .  .  .|||..  |.||.....| |.. ||.  ..| |.| . ..    ...| ..|. .|||. .| ...|||.|.. |. |...  .. |||.|
eengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhC

SNGVGRSGTFCAIYSLLERIKAEQVVDVFQTV
|.||||.|||..| ..|.....|. ||.|..|
saGvgRtgtfvtidiilskleeekkvdifeiv
subfamily_PTPRN_pd Subfamily PTPRN 854-1107 2.5e-59 195.4 In-house 46-291 (297) alignment 
Range on Protein: 854-1107
Range on HMM: 46-291/297.0
FTWEVARRRDNKKRNRYANIIAYDHSRVRLRD---NQESDYINASYLHVKPWRNaegipsvccvqrpAPFVPCKRPLPVTVADFWQLVWQEQVTTIVMLT
 | |||.. .| |.||......||||||.|..   ...||||||| .  .  |.             . .. .. ||. |||||||.||.. |. ||.||
stkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdpra.............payiatqgplastvadfwqmvweqGvvvivnlt

NIVEVGKTKCHRYWPE-GKARHGEFDISLHREEVFA-DYVVRTFIIKKD-EGQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAHYTSRNgqVPMLVH
.. | | ..|.||||. |.. .. ... |  | ... ||.||.| .|     ..| | || . |||..|||  | |.| |||||   |  |    |..||
rleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrs..cpivvh

CSAGVGRTGAFIAIDAMLERAKK-EKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEA
||.|.||||..|.|| .|.| .|  | .||   .. .|..|  ...|.||. |.  || | 
csdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaee
subfamily_PTPN1_pd Subfamily PTPN1 851-1109 4.8e-59 194.5 In-house 19-272 (290) alignment 
Range on Protein: 851-1109
Range on HMM: 19-272/290.0
GQQFTWEVARRRDNKKRNRYANIIAYDHSRVRLRDNQEsDYINASYLHVKpwrnaegipsvcCVQRPapFVPCKRPLPVTVADFWQLVWQEQVTTIVMLT
 ..|. ..|..  |...||| ..  |||||..|....  |||||| ....             ..|   ..  . ||| ||. |||.||...  ..||| 
asdfptreaklpenrnlnryrdvspydhsrikleradn.dyinaslvele............eakrs..yiltqGPlpntvdhfWqmvWeqkskavvmln

NIVEVGKTKCHRYWPEGKA------RHGEFDISLHREEVFADYVVRTFIIKK-DEGQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAHYTSRNGQVP
..|| ...||..|||.|.        . .. . | .||.   |.||.. ...    ..|....| ||.||| |||.  .. | |  |||   .  . . |
kvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGp

MLVHCSAGVGRTGAFIAIDAMLERAKKEKT---VDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEALT
 ..|||||.||.|.|. .|..| . .|..    |||.. .  .|. |  .||| ||  | ..|.||   
avihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGak
Y_phosphatase Protein-tyrosine phosphatase 1166-1365 7.6e-59 194.3 Pfam-A 1-209 (235) alignment 
Range on Protein: 1166-1365
Range on HMM: 1-209/235.0
NIKKNRYPSVVPLDSSRVVLSVDG--GDYINASFADAFRKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQE-DTLTYPQYWP--SKGSETYDH
| |||||....| |..|| |. ..   |||||.. . ... ..||.||.||..|...||.|. |.|. .||||..|.| .  ...||||  ...|.||..
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

LNVRLM-SRE-KQGKLISRKLAIGQKVSEH---EVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQqQCGDKAIVVQCSNGVGRSGTFCAIYSLLERIKA
..|.|. . . .. . . ||| . .| .|.   || .... .|||...| . .|.|||.  |. |. .  .. .||.||.||||.|||.|.  |||...|
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqlea

EQVVDVFQTV
|. |||.|.|
eeevdvlqiv
Y_phosphatase Protein-tyrosine phosphatase 1166-1365 7.6e-59 194.3 In-house 1-209 (235) alignment 
Range on Protein: 1166-1365
Range on HMM: 1-209/235.0
NIKKNRYPSVVPLDSSRVVLSVDG--GDYINASFADAFRKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQE-DTLTYPQYWP--SKGSETYDH
| |||||....| |..|| |. ..   |||||.. . ... ..||.||.||..|...||.|. |.|. .||||..|.| .  ...||||  ...|.||..
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

LNVRLM-SRE-KQGKLISRKLAIGQKVSEH---EVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQqQCGDKAIVVQCSNGVGRSGTFCAIYSLLERIKA
..|.|. . . .. . . ||| . .| .|.   || .... .|||...| . .|.|||.  |. |. .  .. .||.||.||||.|||.|.  |||...|
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqlea

EQVVDVFQTV
|. |||.|.|
eeevdvlqiv
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 845-1106 1.5e-58 192.9 In-house 1-262 (270) alignment 
Range on Protein: 845-1106
Range on HMM: 1-262/270.0
FQTLPSGQQFTWEVARRRDNKKRNRYANIIAYDHSRVRLR---DNQESDYINASYLHvkpwrnaegipsvCCVQRPAPFVPCKRPLPVTVADFWQLVWQE
|. |. ... . ..     .|| ||||.|.   ..||||    ..... |||| |..                .... ..  . ||| |. .||...|.|
fkeldkeetsesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvr.............GfdgekkkYiaamgPlpttlksfwrmiwee

QVTTIVMLTNIVEVGKTKCHRYWPEGKA-----RHGEFDISLHREEVFADYVVRTFIIKkDEGQSRQVVQFQYTSWPDKGVPRHAT------SVLGFRRK
.||.|||.|...| |..|| ||||. .      ..|.  .    ||    |...   .. ..|..|..| |.|..|||.||||..       ..|   |.
kvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle.ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlra

VRAHYTSRNGQVPMLVHCSAGVGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLE
||.. .. . . |.|||||||||||| .||.| ...  ...| ||. . .. .|..|. ..|. .||.|.. ||.|
vrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
0040439 (Phosphotyrosine protein) phosphatases II 1160-1365 1.9e-58 193.3 In-house 5-218 (249) alignment 
Range on Protein: 1160-1365
Range on HMM: 5-218/249.0
VGRADYNIKKNRYPSVVPLDSSRVVLSV----DGGDYINASFADAFRKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQED-TLTYPQYWPSKG
|..   |..|||||...|.|.|||.||.     ..||||||. | ..  ..||.||.||..|.. ||.|. ...|..||||..|.|    .. ||||..|
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplgg

SETYDHLNVRLMSREKQGKLISRKLAIG--QKVSEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQC-GDKAIVVQCSNGVGRSGTFCAIYSLLE
| .|... |.|.| |. .... |.| .   .. ....| |||.. |||  .| . ...||.. .|.  ....  .. ..| ||.||||.|||.|.| .||
sleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmle

RIKAEQVVDVFQTV
... |. ||....|
qlekelgvdleeav
0042113 (Phosphotyrosine protein) phosphatases II 1161-1365 7.7e-58 191.1 In-house 4-215 (245) alignment 
Range on Protein: 1161-1365
Range on HMM: 4-215/245.0
GRADYNIKKNRYPSVVPLDSSRVVLSVDG----GDYINASFADAFRKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQEDT-LTYPQYWPSKGS
..   |..||||....|.|..||.||.||     ||||||. | .|  . ||.||.||..| . ||.|. ...| |||||... |.   ...||||...|
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplges

ETYDHLNVRLMSREKQGKLISRKLAIG--QKVSEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQCGDKAIVVQCSNGVGRSGTFCAIYSLLERI
 ||... |.|.| |. .... |.| .   ..  ..||.|.... ||| ..| .....||....|.  ....... ..| || ||||.|||.|.| .||..
ltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleql

KAEQVVDVFQTV
..|. |.....|
ekelgvsleeav
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1128-1365 3e-57 188.9 In-house 12-251 (288) alignment 
Range on Protein: 1128-1365
Range on HMM: 12-251/288.0
AAVKPTQNLSGYALEYQRLLAVSSqieDENSKVGRADYNIKKNRYPSVVPLDSSRVVLSV----DGGDYINASFADAFRKRNAFILTQAPLEHTMAEFWH
.| |  .| .|.  ||. | |. .   ......||   | |||||. ..|.|  || |      .| ||||||. |  .|....| ||.|| .|. .||.
vakksarnrtgfseeynsLaalek...tksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWe

MICQYKIGTIVMLNNL-QEDTLTYPQYWPSKGS-ETYDHLNVRLMSREKQGKLISRKLAIGQKVSEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQ
.. ..|. |||||..| ...  .  .|||...  . | ...| |.. ..... . ||| ...| .| |. . |.  |||.  | ... .|.|.. |. ..
lvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvan

QQCgDKAIVVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTV
|.   . |.|.||.||||.||| |.  |......|...||. ||
qad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtv
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 840-1115 4e-57 188.4 In-house 21-243 (392) alignment 
Range on Protein: 840-1115
Range on HMM: 21-243/392.0
VLVAVFQTLPSGQQFTWEVARRRDNKKRNRYANIIAYDHSRVRL---RDNQESDYINASYlhvkpwrnaegIPSVCCvqrPAPFVPCKRPLPVTVADFWQ
...  |. ||. . .   ||.. .|.|.||| ||. || .||.|    |  .|||.||||           |||. .      .. .. | . .. |||.
lffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasy...........ipsfdn...ekayiasqgpnaaslddfwr

LVWQEQVTTIVMLTNIVEVGktkchrywpegkarhgefdislhreevfadyvvrtfiikkdEG-QSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAHY
.|.||.||||.|.|.. |                                            | . | | ||..| ||||.||.|..|.| | ..|.|..
mvfqenvttiamvtklkegd.........................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadf

TSRNgqVPMLVHCSAGVGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEALTCGNTEI
 .     |...||||||||||  |.||... .||| . ||. |.|  .|..|  |.||..||||.. |||| |   || |
Gqyt..hpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntli
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1137-1364 2.1e-56 186.3 In-house 22-254 (305) alignment 
Range on Protein: 1137-1364
Range on HMM: 22-254/305.0
SGYALEYQRLLavsSQieDENSKVGRADYNIKKNRYPSVVPLDSSRVVLSVDG----GDYINASFADAFRKRNAFILTQAPLEHTMAEFWHMICQYKIGT
.|.  .|. |    ..  .|  .||. . | .|||. ....|| .|. |. .      ||||||. |........|..|.||..|.|.||..| ..|. |
kgleaqyksly...ee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvst

IVMLNNLQE-DTLTYPQYWPSKGSE--TYDHLNVRLMSREKQGKLISRKLAIGQ---KVSEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQCGD
|||| .|.| .     |||| . .|   .....| | |...   .| ||| | .   .  .. |.. |  .|||.  |    |.|.|.  || .|..  .
ivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkg

KAIVVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQT
....| ||.||||.|.|.|.   |||.|.|.|||||. 
vpllVhCsagvgRtGvfiavdialerlkkEevvdvfev
0045098 (Phosphotyrosine protein) phosphatases II 1159-1365 8e-56 184.8 In-house 26-243 (278) alignment 
Range on Protein: 1159-1365
Range on HMM: 26-243/278.0
KVGRADYNIKKNRYPSVVPLDSSRVVlsvdggDYINASFADAFrkRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQED-TLTYPQYWPSKGSET
 ..    |..||||....|.|.|||.      ||||||. | .  ...||.||.||..|.| ||.|. ...| .||||..|.|.    ..||||..||.|
tpalylgnldknRykdilpydhsrVk......dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggslt

YDHLNVRLMSREKQGKLISRKLAIG------QKVSEHEVVHIQHIEWPDKCAPVNH--QSVLDLVSWVQLSQQ------------QCGDKAIVVQCSNGV
|... |.|.| |  .. . |.| .       .   ...| |.. . ||| ..| ..  .|.|.|. ...  ..            . ... ..| || ||
ygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGv

GRSGTFCAIYSLLERIkaEQVVDVFQTV
||.||..|.| .||..  |..||....|
gRtGtlvaaylmlell..eggvdlleav
subfamily_PTPN23_pd Subfamily PTPN23 859-1107 3.3e-55 181.9 In-house 38-279 (288) alignment 
Range on Protein: 859-1107
Range on HMM: 38-279/288.0
ARRRDNKKRNRYANIIAYDHSRVRLRdNQESDYINASYLHvkpwrnaeGIPSVCcvqrPaPFVPCKRPLPVTVADFWQLVWQEQVTTIVMLTNIVEVGKT
|  . . ..||. .|. |||.|| || ... ||||||...        .. ..|    | .|.  . ||. |..|||..|..... .||||..  | ||.
aiaklyseknrsrdilPyDhnRvklr.gskDDYinAsfvk........dlspgc....P.dfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkp

KCHRYWPEGK---ARHGEFDISLHREEVFADYVVRTFIIK-KDEGQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAHYT--SRNGQVPMLVHCSAGV
|..||||| |    ..|.....|....    .| |..... .|. . ..|.  |.||||. |||    ..| |  .|...|.   |. ..|..|||||||
kvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGv

GRTGAFIAIDA-MLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEA
||||.|  . | . |  |..  .|| . |. .|..|  |.|...|. |.  |||||
gRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_PTPN14_pd Subfamily PTPN14 855-1107 3.4e-55 182.1 In-house 40-295 (300) alignment 
Range on Protein: 855-1107
Range on HMM: 40-295/300.0
TWEVARRRDNKKRNRYANIIAYDHSRVRLRDNQE--SDYINASYLHVkpwrnaegipSVCCVQRpaPFVPCKRPLPVTVADFWQLVWQEQVTTIVMLTNI
. ..|.  .|...||. ... |...||.|  ..|  ..||||| ..|          ||.  .|   .. .. ||. || ||||.||...|. |||||..
llstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikv..........svggker..syivaqgPleltvqdfWqmvWeqgvqlivmltee

VEVGKTKCHRYWPEG-----KARHGEFDISLHREEVFADYVVRTFIIKK-DEGQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKV---RAHYTSR----N
 | ||.|...|.|.      ....|.| .. .  |    .. ... .|    .. |.|. .||| |||.|||.  .. | . ..|   | . .|     .
eedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveske

GQVPMLVHCSAGVGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEA
 . |.||||||||||||  |  | ...  ......||.. .. .|. | ...||  || ||. .... 
skPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvliky
subfamily_PTPRA_pd Subfamily PTPRA 1159-1365 1.3e-54 180.3 In-house 51-267 (330) alignment 
Range on Protein: 1159-1365
Range on HMM: 51-267/330.0
KVGRADYNIKKNRYPSVVPLDSSRVVLSVDGG----DYINASFADAFRKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQEDT-LTYPQYWPSK
..   . | .|||.. ..| | |||.|||  |    ||||||| | ..... || .| |.|.|. .|| || ..|  ||||| .|.|       ||||..
elaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPde

GSETYDHLNVRLMSREKQGKLISRKLAIGQ---KVS---EHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQCGDkAIVVQCSNGVGRSGTFCAIY
|. || ...| .   .   ..  ||. . |   .     .  |  .    |||   |.. . .|.|.  |.  .|| .. .||| || ||||.|||... 
GlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivld

SLLERIKAEQVVDVFQTV
..|||.|||..||||..|
avlervkaerkvdvfefv
subfamily_PTPRK_pd Subfamily PTPRK 1159-1365 6.7e-54 177.8 In-house 36-249 (314) alignment 
Range on Protein: 1159-1365
Range on HMM: 36-249/314.0
KVGRADYNIKKNRYPSVVPLDSSRVVLS-VDGG---DYINASFADAFRKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQEDT-LTYPQYWPSK
 . . | | .|||.  ... | |||.|  .||    |||||.. |.... .||| || ||..|...|| .. ...  .||||..|.| . .   .||| .
daakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed

GSEtYDHLNVRLMSREKQGKLISRKLAIGQ----KVSEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQcGDKAIVVQCSNGVGRSGTFCAIYSL
..  |....| |.. | . .|..| ... .    .   .|| ..|.. |||   ||. ...|.||  |. ||.. ..  ||| ||.| ||.|||.|| ..
tev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidiv

LERIKAEQVVDVFQTV
|. |. |.|||||..|
ldmieregvvdvfnav
subfamily_PTPRG_pd Subfamily PTPRG 1136-1365 5.9e-53 174.9 In-house 18-259 (563) alignment 
Range on Protein: 1136-1365
Range on HMM: 18-259/563.0
LSGYALEYQRLLAvSSQIEDENSKVGRADYNIKKNRYPSVVPLDSSRVVLSVDGG-----DYINASFADAFRKRNAFILTQAPLEHTMAEFWHMICQYKI
  |.. |.. |    .. .| . .  ..  | .|||| ..|. |.||| ||   |     |||||.. | ..| .||| || ||..|.  ||.|| . . 
digfseefealqs.etiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnv

GTIVMLNNLQEDT-LTYPQYWPSKGSETYDHLNVRLMSREKQGKLISRKLAIGQ------K--VSEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQ
 .|||. ||.|..    ..|||. .||||..|.|.|...|.     .|.| | .      |   .|..| . .  .|||...|     ||  |   . ..
aiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaan

QQ-CGdkAIVVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTV
..  |   ||| ||.||||.||.... .||..|..|..|.||...
kaeaG..PivvHcsaGvgrtGtyivldtllkqiqqenavnvfgfl
subfamily_Ptp69D_pd Subfamily Ptp69D 1134-1365 2.1e-52 173.2 In-house 19-258 (307) alignment 
Range on Protein: 1134-1365
Range on HMM: 19-258/307.0
QNLSGYALEYQRLLAVssqIEDENSKVGRADYNIKKNRYPSVVPLDSSRVVLSV----DGGDYINASFADAFRKRNAFILTQAPLEHTMAEFWHMICQYK
.   |.| ||..| |      | ..||.  . |  ||||. ... |. ||.|..    .  |||||||  ...... ||  |.|.| |. .|| || . .
dtdfglakeyekLear...eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqe

IGTIVMLNNLQEDTLT-YPQYWPSKGSETYDHLNVRLMSREKQGKLISRKLAIGQKV-------SEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQ-LS
. .|||| ||.| .    ..|||      |....|.|.| ||... | |.| . .|         ...||  .. .|.|  .|   ...|.|.. |. | 
vtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrely

QQQcgDKAIVVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTV
...     ||| ||.||||||.| |. |||...|||. ||.|.||
kln..rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetv
0037934 (Phosphotyrosine protein) phosphatases II 1161-1363 3e-52 173.0 In-house 5-211 (243) alignment 
Range on Protein: 1161-1363
Range on HMM: 5-211/243.0
GRADYNIKKNRYPSVVPLDSSRVVLsvDGGDYINASFADAFRKrnaFILTQAPLEHTMAE----FWHMICQYKIGTIVMLNNLQ-EDTLTYPQYWPskGS
..  .|..||||....|.| |||.|  .|.|||||.. . ...   .|.||.||..| ..    ||.|. ...|..||||..|.  . . ..||||  |.
allpenlsknrysdilpydhsrvkl..egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..ge

ETYDHLNVRLMSREKQGKLISRKLAIGQ---KVSEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQ-------CGDKAIVVQCSNGVGRSGTFCA
.||... |.|.| |  .. . |.| .     .  ...|.|.... ||| ..| .....||....|.  ...        ... ..| || ||||.||..|
vtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtlia

IYSLLERIkaeQvVDVFQ
.| .|...   . ||...
aylmllll...g.vdlee
subfamily_PTPRB_pd Subfamily PTPRB 1135-1365 1.8e-50 166.6 In-house 23-257 (293) alignment 
Range on Protein: 1135-1365
Range on HMM: 23-257/293.0
NLSGYALEYQRLLAVSSqieDENSKVGRADYNIKKNRYPSVVPLDSSRVVL----SVDGGDYINASFADAFRKRNAFILTQAPLEHTMAEFWHMICQYKI
.  ... ||..| || .   |.. |. ..  | .||||  ..| | ||| |    . .| |||||.. . .. .. || || || .|. .||.|. . | 
sdlrfseeyeelkavgk...dqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekks

GTIVMLNNLQEDTL-TYPQYWPSK-GSETYDHLNVRLMSREKQGKLISRKLAIGQKVSEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQ-QQCGDK
 .|||| .| |       .|||..  . .| ...| |.. |.. . . |.|.| .. .|..| . ... |||   | . ...||.|  |. .. ... ..
siivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskr

AIVVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTV
 ||| || ||||.||| |.  ||..|. |..||.| .|
PivvhCsaGvGRtGtfialdrllqaieeedyvdifgiv
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1157-1365 2.1e-50 166.4 In-house 35-249 (315) alignment 
Range on Protein: 1157-1365
Range on HMM: 35-249/315.0
NSKVGRADYNIKKNRYPSVVPLDSSRVVL----SVDGGDYINASFADAFRKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQE-DTLTYPQYWP
. .|.| . | |||||  ..||||.||.|         ||||||.  .. . .|.| .|.||. .. .||.|. |.|. ||||....|| | .   ||||
rqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywP

S--KGSETYDHLNVRLMSREKQGKLISRKLAIGQKVSEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSqQQCGDKAIVVQCSNGVGRSGTFCAIYSL
     |  .  ..| |.| | ..  . ||| . .  . . |   |  ||||| .. .  |.| |.  |. . ..  . ...| || ||||.| ...| . 
drkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvisidev

LERIKAEQVVDVFQTV
...|| ...||||..|
vaqikrtrsvdvfnfv
subfamily_CG7180_pd Subfamily CG7180 858-1112 7.8e-50 164.2 In-house 36-294 (296) alignment 
Range on Protein: 858-1112
Range on HMM: 36-294/296.0
VARRRDNKKRNRYANIIAYDHSRVRLR---DNQESDYINASYlhvkpwrnaegipsVCCVQRPAPFVPCKRPLPVTVADFWQLVWQEQVTTIVMLTNIVE
 . | .|...||. ... ||. || |.    ...||||||.|              |    ... ..  . |   || .||.||..|.. ..|.||.  .
gglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavy..............vdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfd

VGKtKCHRYWPEG-KARHGEFDISLHREEVFADYVVRTFIIKKD-----------EGQSRQVVQFQYTSWPD-KGVPRHATSVLGFRRKVRAHYTSR---
  | ... |||.  |...||. . . .|. .|. . ||| ..|            . . | | .||.| |.  . ||  ..... .||.||         
fak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvded

NGQVPMLVHCSAGVGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEALTCGN
. . |..|..| |..|.|...|||| || ..||. ||. ..|  .|..|  .... ..| ..   .|||. |. 
peegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 863-1120 2.2e-49 163.1 In-house 47-291 (439) alignment 
Range on Protein: 863-1120
Range on HMM: 47-291/439.0
DNKKRNRYANIIAYDHSRVRLRD---NQESDYINASYLHvkpwrnaeGipsvccVQRPAPFVPCKRPLPVTVADFWQLVWQEQVTTIVMLTNIVEVGKtk
 .. .||| .. |.||.|| |..      | |||| |..        |         .  .. .. |   |. |||.||......|||||||.||  |  
ydqtknrykdvgafdhtrvtlqeipgvphshyinanyik........G......yyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk..

chrYWPEG-KARHGEFDISLHREEVFADYVVRTFII--KKDEG-QSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAHYTSrNGQVPMLVHCSAGVGRT
   |||   .. .|.  .   |.  . .||.| | .  ..| . . | |.||.|..|||| || .|. || | | . .   . .   |..||||||||||
...ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandk.eeygpvvvhcsagvGrt

GAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEALTCGNTEIEAGNL
|. ||.|  ||. | |. |||.  |.|.|..|  |.|.  || |.. |||| .  |.. .  ...
GtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidef
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 844-1114 3.4e-49 162.2 In-house 20-299 (301) alignment 
Range on Protein: 844-1114
Range on HMM: 20-299/301.0
VFQTLPSGQQFTWEVARRRDNKKRNRYANIIAYDHSRVRLRDNQESDYINASYLhvkpwrNAEGIPSvccVQRPAPFVPCKRPLPVTVADFWQLVWQEQV
 ...| .|.. . .|  . .||. ||. ||  ||. |. |. ... |  . .|.      ||. | .   ...   |.  . |.  |..|||.|.|||..
qykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyi......nasyidg...ysekkkfiaaqgpmkktlvdfWrliwqekp

TTIVMLTNIVEVGKTKCHRYWPEGKAR---HGEFDISLHREEVFADYVVRTFIIKKD-----------------EgQSRQVVQFQYTSWPDKGVPRHATS
..|||.||  |  |.||..|||...|.    |.| . |. | |. |.|.| . .|                     .|..|.|.| |.||. || |    
vsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk.sswdvlqlqvtdWpqdGvvreprt

VLGFRRKVrAHYTSRNGQVPMLVHCSAGVGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEALTCGNTE
||    .|  | . . |  |..||||..|.|.| .....  || .| |  ||. . .. .| ..  ...| .|| ... .. . |.. .|.
vLqviddv.ihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnsty
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1124-1361 3.7e-49 162.3 In-house 2-244 (281) alignment 
Range on Protein: 1124-1361
Range on HMM: 2-244/281.0
MRKRAAVKPTQNLSGYALEYQRLLAVSSqieDENSKVGRADYNIKKNRYPSVVPLDSSRVVLS----VDGGDYINASFADAFRKRNAFILTQAPLEHTMA
.||... . ... .|.. ||. | |.     |. ..  .|| |..||||  .|  | .||...        |||||.| ..... ...| ||.|. ....
lrkhlkqlsqndnaGfieeyeklaaigv...dntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslv

EFWHMICQYKIGTIVMLN-NLQEDTLTYPQYWPSKG-SETYDHLNVRLMSREKQGKLISRKLAIGQ-KVSEHEVVHIQHIEWPDKCAPVNHQSVLDLVSW
.||.|. ..|. .|||.  ..... |   .||| .  . .| .. |. ...|.. . |.||. . . .  . ||...... |||. .| . . .|.  . 
afWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrke

VQLSQQQCGDKAIVVQCSNGVGRSGTFCAIYSLLERIKAE-QVVDV
|.  ...  . ..|. || ||||.||. |.  |.....|| . .||
vlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldv
0051429 (Phosphotyrosine protein) phosphatases II 889-1108 7.7e-49 162.1 In-house 4-225 (272) alignment 
Range on Protein: 889-1108
Range on HMM: 4-225/272.0
SDYINASYLHVKpwrnaegipsvCCVQRPAPFVPCKRPLPVTVADFWQLvWQEQVTTIVMLTNIVEVGKTKCHRYWP-------------EGKARHGEFD
|.||||...              . | .|  .  . .|||.|.||||.| ......|||.|.. .|.|. ||.||||             .   ..| . 
sgyiNardvggy...........grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalr

ISLHREEVFADYVVRTFIIKK--DEGQSRQVVQFQYTSWPDKGVPRHAtsVLGFRRKVRAhytsrngQVPMLVHCSAGVGRTGAFIAIDAMLERAKKEKT
. |. ||.. ||..|......  . |..|.| ...||.||| |||..|  .| . . ...       . |.|||||||..||| ..|.. .|..  .|  
vtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.......ggpvlvHCsaGkdRTGtvvallllllgvsleti

VD--------IHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEAL
||        . ..|. .|  |  ..|||.||.|.. |.||.|
vddYlltnlyleeaveelraqrpgavqteeqylflyeallell
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1135-1364 8e-49 161.0 In-house 18-254 (290) alignment 
Range on Protein: 1135-1364
Range on HMM: 18-254/290.0
NLSGYALEYQRLlavSSQIEDENSKVGRADYNIKKNRYPSVVPLDSSRVVLSVDGG--D----YINASFADAFRKRNAFILTQAPLEHTMAEFWHMICQY
. .|.  ....|    |  .... .|| .  | ..||.  .|. |  |..|   .|  |    ||||.. . .......|.||.|...|...||..| | 
gnegfrnqfkml...dsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqe

KIGTIVMLNNLQED-TLTYPQYWPSKGSETYDHLNVRLMSREKQGKLISRKLAIGQKVS---EHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQC
|.  |||| | .|. . .  ||||......|.. ...|.. |.  . | ||| . .| |   ...|.. |   |...    |.|..| ... ..  | . 
kvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkr

GDKAIVVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQT
|...||| ||..||||..|||..  ... | |.|.|||| 
gntsivvHCSdtvgrsavfcaaattinkcktegvidvfqv
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1159-1365 3.8e-48 159.1 In-house 44-256 (297) alignment 
Range on Protein: 1159-1365
Range on HMM: 44-256/297.0
KVGRADYNIKKNRYPSVVPLDSSRVVLSVDGG----DYINASFADAFRKrnAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQEDTLTYPQYWPSKG
 | .   |..|.||  ..| ||||| | . .     ||.||||  ....   .| || | . |.|.|| |. .... ||||||...| .    .||. ||
tvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdkg

SETYDHLNVRLMSREKQGKLISRKLAIGQKV--SEHEVVHIQHIEWPDKCAPV--NHQSVLDLVSWVQLSQQQCGDKAIVVQCSNGVGRSGTFCAIYSLL
. |. .. | |.| ...   | |.| . .    ... |   |..|||||  .   . .|.|.|.| |. . .|  .  ..| |..|||| | ...| | .
vttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvv

ERIKAEQVVDVFQTV
 ..| |. ||.|..|
aeakrekevdifglv
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1138-1364 2.2e-47 156.4 In-house 21-249 (287) alignment 
Range on Protein: 1138-1364
Range on HMM: 21-249/287.0
GYALEYQRLLAVSSQiEDEnSKVGRADYNIKKNRYPSVVPLDSSRVVLSVDGGDYINASFADAFRKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLN
|.   .. |  |. . |||   .. |  | .|||.  ... |  ||.|     |||||.| |......|||....|. .|. .||..| . .. .|||| 
gfknqftvleqvtqr.ede.vthniasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlc

NLQEDT-LTYPQYWPSKGSETYDHLNVRLMSREKQGKLISRKLAIGQKV---SEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQCGDKAIVVQC
...|..     ||||.. | .. . |..|...|.. . | ||| . .|    ....|.  |  .|...    ..|..| ..     .|.. |. .||| |
qekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhC

SNGVGRSGTFCAIYSLLERIKAEQVVDVFQT
|..||||..|||.   ... | | |.|||| 
sdtvGrsamfcaaattinkckteGviDvfqv
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1160-1365 6.6e-47 154.7 In-house 37-248 (515) alignment 
Range on Protein: 1160-1365
Range on HMM: 37-248/515.0
VGRADYNIKKNRYPSVVPLDSSRVVLSV----DGGDYINASFADAFRKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQE-DTLTYPQYWPSK-
| . . | |||||  ..|.||.|| | |       ||.|||.  .|   .|.| .|.|.. .. .||... |... ||.|...|.| |     .||| | 
vaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkp

-GSETYDHLNVRLMSREKQGKLISRKLAIGQKVSEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQCGdKAIVVQCSNGVGRSGTFCAIYSLLER
  |  . ...| |.| |  .  | ||| . .    . |   .  ||||| .| . .|.| |.  |. ...|    .... || |||| | ...| | . .
gdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvvah

IKAEQVVDVFQTV
.|  ..||||..|
akttrmvdvfnfv
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 851-1105 6.9e-47 154.6 In-house 25-274 (287) alignment 
Range on Protein: 851-1105
Range on HMM: 25-274/287.0
GQQFTWEVARRRDNKKRNRYANIIAYDHSRVRLRDN--QESDYINASYlhvkpwrnaegipsVCCVQRPAPFVPCKRPLPVTVADFWQLVWQEQVTTIVM
.  .|.  |    . |.||||... .|..|| |  .  . |||||| |              |   ..   |. .. |.. || |||..|..........
sstatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinany..............vasytddeafiaaqgPiaatvrdfwravletrsasvit

LTNIVEVGKTKCHRYWPEGK--ARHGEFDIS-LHREEVFADYVVRTFIIKKDEGQS-RQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAHY---TSRNGQ
.|  || .. ||..|||| .   | | . .  | ..    .| ||.. . . |..  | | |... |||||...  | ... |  .|. |     . .. 
mtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasev

VPMLVHCSAGVGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVL
 |..||...|.||.| ..|. ....| ..   ||. . |  .|. | ...|.  |. ..  |. 
GPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1129-1365 9.1e-47 154.7 In-house 15-260 (325) alignment 
Range on Protein: 1129-1365
Range on HMM: 15-260/325.0
AVKPTQNLSGYALEYQRLLAVSSQiedeNSKVGRADYNIKKNRYPSVVPLDSSRVVLSVDG----GDYINASFADAFRKRNAFILTQAPLEHTMAEFWHM
  | .|.  |.| |.. | .. ..      ||     |..|||.. ||.|| |||||   .     ||||||.   ..|.. |. .|||| .|. ..| .
ekkkaqdqdgfahefgllpsddgi....akkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrl

ICQYKIGTIVMLNNLQEDTLTYPQYWPSK--GSETYDHLNVRLMSREKQGKLISRKLAIGQKVSE--HEVVHIQHIEWPDKC---APVNHQSVLDLVSWV
.....   .|.|| |...     .||| .   | |.  |.|.|.. |.    . |.| . |        |   |.  |.|      |    |.|.||  |
vldWrcsvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkav

QLSQ--QQCGDKAIVVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTV
.     .  .   |.| ||.||||.|.| ..||.|...  |  ||.|. |
servtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfv
subfamily_PTPN12_pd Subfamily PTPN12 1134-1364 2.6e-46 152.8 In-house 5-248 (290) alignment 
Range on Protein: 1134-1364
Range on HMM: 5-248/290.0
QNLSGYALEYQRLLAVSSQIEDEN---SKVGRADYNIKKNRYPSVVPLDSSRVVLS----VDGGDYINASFADAFRKRNAFILTQAPLEHTMAEFWHMIC
..   .| |.|.| ..|..  .|.   ...|....|.|||||  ..| | |||.||    ..| |||||.|     .. ..| .|.|| .|. .||.|| 
egeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiw

QYKIGTIVMLNNLQE-DTLTYPQYWPSKGSET--YDHLNVRLMSREKQG-KLISRKLAIGQKVSEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQ
....  .||. .. | .     .|||..| |.  .....| |.. ..    .. | |.. ..  ...|  ... .|||.  | ...|.|.|.. |.  |.
eknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqe

qCGDKAIVVQCSNGVGRSGTFCAIYSLLERIKAEQV---VDVFQT
   |. .|| || |||| || .||    | .|||..   .|||. 
.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdl
subfamily_CG7180_pd Subfamily CG7180 1128-1365 3.3e-46 152.3 In-house 4-262 (296) alignment 
Range on Protein: 1128-1365
Range on HMM: 4-262/296.0
AAVKPTQNLSGYALEYQRLLAVSSQIEDENSKVGRADYNIKKNRYPSVVPLDSSRVVLS-VDG---GDYINASFADAFRKRNAFILTQAPLEHTMAEFWH
. .| ...   . .||. .| . ...| .. . |    |..|||.. ||| |  ||||. .||    |||||.. |.| | ...| |.|| ..|. ||| 
kflklvdkrrkfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWr

MICQYKIGTIVMLNNLQEDTLTYPQYWPSKGSETYDHLNVRLMSREKQGKLISRKLAIGQK------------VSEHEVVHIQHIEWPD-KCAPVNHQSV
.. . .| ..|.| .  . .  ||.||| |. | | .. | ... ..  .| .|.. . .|            . .  | ..|  ||.  .  |.  ...
lvydeeisavvvLtktfdfakmypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnal

LDLVSWVQLSQQQC----GDKAIVVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTV
..|.  |.| ...       . .|| .|.|..||| ..||   || .. |. ||||. |
ielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeav
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1159-1364 8.6e-46 151.3 In-house 42-250 (315) alignment 
Range on Protein: 1159-1364
Range on HMM: 42-250/315.0
KVGRADYNIKKNRYPSVVPLDSSRVVL----SVDGGDYINASFADAFRKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQEDTLTYPQ-YWPSK
.| .   | .||||  ... | ||| |      .. ||.||.| | . |.. .| .|.|.  .. .|| .. ...||.||||.|| |.     . ||| |
dvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk

gSETYDHLNVRLMSREKQGKLISRKLAIGQKVSEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQCGdKAIVVQCSNGVGRSGTFCAIYSLLERI
   .| .. | ..| |.. ..  | |..  .   .||| ...  |||   |    ....|.  |.  ...    |||| ||.||||.|||... ..|...
.kviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavldqa

KAEQVVDVFQT
.||...||.. 
eaenaidvynf
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1133-1365 2e-45 150.5 In-house 30-263 (319) alignment 
Range on Protein: 1133-1365
Range on HMM: 30-263/319.0
TQNLSGYALEYQRLLAVSSQIEDENskVGRADYNIKKNRYPSVVPLDSSRVVLS----VDGGDYINASFADAFRKRNAFILTQAPLEHTMAEFWHMICQY
 ..|. .  |..|.  .. .  | .      | |  |||.  ... | ..| |     ... ||||||| . ..... .| .| ||. |.|.|| || .|
dddltklevefrracklgvnladqt..fanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiwey

KIGTIVMLNnlqedTLTYPQYWPSKGSETYDHLNVRLMSREKQGKLISRKLAIGQKVSEHEVVHIQ---HIEWPDKCAPVNHQSVLDLVSW-VQLSQQQC
.. |||.|           |||| |. ..... .|.. | |.  . . |.. . ..  |... .|.      |||.  |     .. ||     | ... 
ncstivllt.....kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltsken

GDKAIVVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTV
. . ||| || ||||.|.. ..  ||.|.| |. |||...|
hranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfv
0041856 (Phosphotyrosine protein) phosphatases II 864-1114 4.9e-45 148.7 In-house 1-177 (182) alignment 
Range on Protein: 864-1114
Range on HMM: 1-177/182.0
NKKRNRYANIIAYDHSRvrlrdnqESDYINASYLHvkpwrnaegipsvcCVQRPAPFVPCKRPLPVTVADFWQLVWQEQVTTIVMLTnivevgktkCHRY
|...||| .|. |||||        .|||||...               . ...  |. ...||. |||||.........||||.||         ...|
nldknrysdilpydhsr.......dldyInanlyl..............gslpatrfiatqgpllstvadflrmlkelgittivnlt.........eely

WPegkarhgefdislhreevfadyvvrtfiikkdEGQSRQVVQFQYTSWPDKGVPRhATSVLGFRRKVRAhytsrnGQVPMLVHCSAGVGRTGAFIAIDA
||                                |   |...|..|..||| |||    ..| | ..|..       . | ||||||||||||...|.. 
wp................................ellerlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgtlvaayl

MLERakkekTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEALTCGNTE
|...      |.. . |. .|. |. |..|..|| |.. |.|| | ...|.
mkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlallellllkktr
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1142-1365 2.6e-44 146.8 In-house 3-227 (284) alignment 
Range on Protein: 1142-1365
Range on HMM: 3-227/284.0
EYQRLLAVSSQIEDENskVGRADYNIKKNRYPSVVPLDSSRVVLS----VDGGDYINASFADAFRKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLN
|..|.  .. .  | .      | |  |||.  ... | ..| |     ... |||||||   ..... .| || ||. |.|.|| || .|.. |||.| 
efrracklgvngtdqt..fanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt

nlqedTLTYPQYWPSKGSETYDHLNVRLMSREKQGKLISRKLAIGQKVSEHEVVHIQ---HIEWPDKCAPVNHQSVLDLVSW-VQLSQQQCGDKAIVVQC
          |||| |. ..... .|.. | |.  . . |.. . ..  |... .|.      |||.  |     .. ||     |.... . . ||| |
.....kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhc

SNGVGRSGTFCAIYSLLERIKAEQVVDVFQTV
| ||||.|.. ..  ||.|.| |. |||...|
sagvgrtgvyivldvlldrmkeekqvdvynfv
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1152-1365 6.6e-44 144.9 In-house 19-238 (283) alignment 
Range on Protein: 1152-1365
Range on HMM: 19-238/283.0
QIEDENSKVGRADYNIKKNRYPSVVPLDSSRVVLSVDGGDYINASFAD---AFRKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQEDT-LTYP
 . | ....  || | .|||.  .|| |  || |  .  |||||.|       .. . .| .|.||..|. .||.|. . || .|||| .||||      
svpdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCs

QYWPSKGSETYDHLNVRLMSREKQGKLISRKLAIGQK---VSEHEVVHIQHIEWpdkcAPVNHQSVLD---LVSWVQLSQQQCGDKAIVVQCSNGVGRSG
||||..||| |  . | |     .  .| ..| . ..    |.  . | | |.|      .. |....    .  |.  |..  .  ||| ||.|.||..
qyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW....leygeqaiinslvkfnkvislqteskkgPivvhCstgiGrta

TFCAIYSLLERIKAEQVVDVFQTV
.|.|. . .. ...| |||||..|
vfiaasasvkdaltesvvdvfavv
subfamily_PTPN23_pd Subfamily PTPN23 1141-1358 2.2e-43 143.1 In-house 19-244 (288) alignment 
Range on Protein: 1141-1358
Range on HMM: 19-244/288.0
LEYQRLlAVSSQIEDENSKVGRADYNIKKNRYPSVVPLDSSRVVLSVDGGDYINASFADAFR-KRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNL
 ... |   . . | ..  .  |  . .|||.  ..| |..||.|     |||||||          || |||||. |...|| |. . |  .|||| . 
kkfkel.eqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllsk

QEDTLT-YPQYWPSKGSE--TYDHLNVRLMSREKQGKLISRKLAIGQKVSE--HEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQL---SQQQCGDKAIVV
.|   .   .|||..  |  ....|.| | | .. .. . |.| .  . ..  ..|.|.|  .||.  .|   ...|...  |.    ..|.  .. .||
eelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvv

QCSNGVGRSGTFCAIYSLLERIKAEQV
.|| ||||.|.|. .|. .. ..... 
hCsaGvgRtgvfalvyaavrelekgng
subfamily_PTPN9_pd Subfamily PTPN9 1158-1365 4.1e-43 142.5 In-house 34-262 (297) alignment 
Range on Protein: 1158-1365
Range on HMM: 34-262/297.0
SKVGRADYNIKKNRYPSVVPLDSSRVVLSV----DGGDYINASFADAFRKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQED-TLTYPQYWP-
 .. .   |..||||  |. .|..||||.     .  |||||.| | .....||| || ||..|. .|| |. . .. .|||   . |   |   |||| 
flasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpl

-SKGSETYDHLNVRLMSREKQGKLISRKLAIG--QKVSEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQ------------QCGDKAIVVQCSNG
 .. |. . .|.|. .. |.. .   |.| |   ..  . .|.| | . |||   | . .|.||... |.  |             .. .  ||| || |
eeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaG

VGRSGTFCAIYSLLERIKAEQVVDVFQTV
.||.|||...   |.|.. ...|||..||
iGrtGtfitldiclsrleevgtvdvvetv
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1167-1365 1.7e-42 140.4 In-house 29-240 (274) alignment 
Range on Protein: 1167-1365
Range on HMM: 29-240/274.0
IKKNRYPSVVPLDSSRVVLSV-----DGGDYINASFADAFR-KRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQEDTL-TYPQYWPSKG----S
 .|||| ...| . |||.|.      .  .|||| .   .. . .|.. || || .|.|.||.|| | ..  |||| .|.|       .|.| .     |
qtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeis

ETYDHLNVRLMSREKQGKLISRKLAIGQKVSEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQCGDK--AIVVQCSNGVGRSGTFCAIYSLLERI
|.|......  .  .. .   ||| . .  .|..|.|. . .|||. .| . ...||||  |. |...   |  ..|| || |.|| | | ||   . ..
erygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrql

KAEQVVDVFQTV
..|.||||...|
reeivvdvlkiv
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1151-1364 8.4e-42 137.9 In-house 25-264 (301) alignment 
Range on Protein: 1151-1364
Range on HMM: 25-264/301.0
SQIEDENSKVGRADYNIKKNRYPSVVPLDSSRVVLSVDG------GDYINASFADAFRKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQEDTL
.. ||....||  . | . ||. .....|  |..|.          .|||||. |.......|| .|.|...|...||..| |.|  .|||. ||.|.| 
kegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtk

-TYPQYWPSKGSETYDHLNVRLMSREKQ-------------------GKLISRKLAIGQKVSEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQC
    ||||.   |...  ..  .  ..|                    . | ||... .. | ..|. .| ..||.     ... ||  .  |   ||. 
skceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqki

GDKAIVVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQT
|   .|| ||..|.|||..|..   ||  ||| |||||| 
gggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqv
subfamily_PTPN3_pd Subfamily PTPN3 1158-1361 1.2e-41 137.5 In-house 33-243 (280) alignment 
Range on Protein: 1158-1361
Range on HMM: 33-243/280.0
SKVGRADYNIKKNRYPSVVPLDSSRVVLSVDGGDYINASFAD----AFRKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQEDTL-TYPQYWPS
 .. |   |..||||  ..| |. || |.    |||||.. .    .    | .| || ||..|...||.|. . |. .|||| .| |.      ||||.
isaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe

KGSE-TYDHLNVRLMSREKQGKLISRKLAIGQKV--SEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSqQQCGDKAIVVQCSNGVGRSGTFCAIYSL
.. | .| ...|.. ..... . . |.| . .|    |......|...|||.. | .....|..|. |.   ..  .. .|| || |.||.| . ..   
tedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrkl.rsgkeePvvvhCsaGigrtGvlilleta

LERIKAEQVVDV
|  | |.. | .
lalieaaepvyp
subfamily_PTPN6_pd Subfamily PTPN6 1136-1357 1.5e-41 137.4 In-house 25-258 (306) alignment 
Range on Protein: 1136-1357
Range on HMM: 25-258/306.0
LSGYALEYQRLLAVSSQIEdENSKVGRADYNIKKNRYPSVVPLDSSRVVL---SVDGGDYINASFAD--AFRKRNAFILTQAPLEHTMAEFWHMICQYKI
 .|.  |...|    ..    . | |.   | .|||| ...| | .||.|   || | |||||.. .  .  .....| ||  ||.|...||.|. | . 
kagfeeefeelqqeeakkl.lsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqens

GTIVMLNNLQED-TLTYPQYWPSKGS-ETYDHLNVRLMSREKQGKLISRKLAIG---QKVSEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQCG
  |||. .  |       .|||.. . |.| ...|. .| ... . | |.| .    .| .|.||.. .. .|||.  | . . |||... |.  |... 
rvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeele

---DKAIVVQCSNGVGRSGTFCAIYSLLERIKAEQ
     .||| ||.|.|| |||  |  ||. |. . 
eaeagpivvhCsaGiGRtGtfiviDillkliekkg
0036282 (Phosphotyrosine protein) phosphatases II 889-1101 2e-40 133.7 In-house 2-163 (174) alignment 
Range on Protein: 889-1101
Range on HMM: 2-163/174.0
SDYINASYLHVKPWRNaegipSVCCVQRPAPfvpckrplpvtvadFWQLVWQEQVTTIVMLTNIVEVGKTKCHRYWPEgkarhgefdislhreevfadyv
|||||||.|..    .      . . | |..              ||........||.|||.. .| |..||..||||                      
sdyinaspldlsyitp.....rliagqgpla..............fwemlkelgittvvmlleekelglykcinywpe......................

vrtfiikKDEGQSRQVVQFQYTSWPDKGVPRHATsVLGFRRKVRAHYTSrNGQVPMLVHCSAGVGRTGAFIAIDAMLERAKkEKTVDIHNYVNVMRNNRC
       . |  .| ..|..|. ||| |||  .. .| | . |. .. . ... |.||||||||||||...|.. || . . |..||. ..|  .|. |.
.......lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrp

TMIQTEDQYAFVH
 |.||..|| |..
gmvqtpsQyrfly
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 851-1104 7.3e-40 131.4 In-house 43-279 (290) alignment 
Range on Protein: 851-1104
Range on HMM: 43-279/290.0
GQQFTWEVARRRDNKKRNRYANIIAYDHSRVRLRDNQESDYINASYLHvkpwrnaeGIPsvccvqrpAPFVPCKRPLPVTVADFWQLVWQEQVTTIVMLT
.|..  ..  .  . |.||| ...  | .|| |.| .. ||. | |..        |.         |.|.  . .|  || |.|..| ||.|..|||| 
vqylerkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvk........Glk........amfiltqGalkdtvidiwrmvlqekvaaivmlc

NIVEVGKTKCHRYWPEGKA---RHGEFDISLHREEVF-ADYVVRTF-IIKKDEGQSRQVVQFQYTSWPDKGVPRHATSVLgfrrkvRAHYTSRNGQVPML
...| ||.||..|.|| .      ||. .    |.   |. . .|. . .||.|.. ..  ..  ||||| |.  . ..|      |  .. |.   |. 
eliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlall......rtlrilrkasGpvv

VHCSAGVGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAV
||||||.||||.|.||.. |.   . | .|. . |  .|| | . .| . ||  .  ..
vhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveil
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1153-1364 4.8e-39 129.0 In-house 18-230 (267) alignment 
Range on Protein: 1153-1364
Range on HMM: 18-230/267.0
IEDENSK--VGRADYNIKKNRYPSVVPLDSSRVVLSVDGGDYINASFADAFRKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQEDTLtyPQYW
| |..|.     |  | ..||.  ..| | .||.|.    .|||||. ......||||.|| ||. |...|. .| ..|. .||.| .  .| .  ...|
isdtsstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdni..rlfw

PSK--GSETYDHLNVR--LMSREKQGKLISRKLAIgQKVSEHEVVHIQHIEWPDKCapVNHQSVLDLVSWVQLSQQQCGDKAIVVQCSNGVGRSGTFCAI
| |   .. |. | |   |   |.. ..|. .| . .. | |.|.   . .|  .    |.  .  |.  .   | . |.. .||.||.||||||||  |
PPkmgqakkyqdltvehslekeendyqiitlelkf.knesahnvtlyyykkwnint..nnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvi

YSLLERIKAEQVVDVFQT
.| |||.| |.|.|.|. 
dsqleraktegvsdifdf
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 862-1104 5.1e-38 125.6 In-house 31-255 (267) alignment 
Range on Protein: 862-1104
Range on HMM: 31-255/267.0
RDNKKRNRYANIIAYDHSRVRLRDNqESDYINASYLHvkpwrnaegipsvcCVQRPAPFVPCKRPLPVTVADFWQLVWQEQVTTIVMLTNiveVGKTKCH
 .|..|||. . . ||..|| ||.. | .||||||..              . ..   |.  . ||  |..||.... ...|..||.||.   |.. . .
eknqernrlddnlpyddtrvilrtk.eeeyinasyve..............gyktknafivtqdplkntitdfltvihdqkvpvivlltk...vftdnir

RYWPEG--KAR---HGEFDISLHREEvfADYVVRTFIIKKDEGQSRQVVQFQYTSWPDKGvprHATSVLGFRRKVRAHYTSRNGQVPMLVHCSAGVGRTG
..||    .|.       . || .||   || . |. .|  .  ...|. . |  |  .         |     . |.    ||. |..|.||.||||.|
lfwPPkmgqakkyqdltvehslekee..ndyqiitlelkfknesahnvtlyyykkwnint...nnkpylkplfgilaknqlengnrPlvvacsdGvGrsG

AFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAV
.|. ||..|||||.| ..||....  .|. | ....| ..| ..|  .
tflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihell
subfamily_PTPN13_pd Subfamily PTPN13 1156-1365 6.6e-38 125.5 In-house 27-241 (273) alignment 
Range on Protein: 1156-1365
Range on HMM: 27-241/273.0
ENSKVGRADYNIKKNRYPSVVPLDSSRVVLSVDGGdYINASFADAFRKRN--AFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQE-DTLTYPQYWPS
....||. . | .||||  |.| | .|| |. .|| |||||.  .    .   .|..| || .|...|| |. . |   |.|. . .| . .   .|||.
dtcevgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPe

KGSET---YDHLNVRLMSREKQGKLISRKLAIGQKVS--EHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQqcGDKAIVVQCSNGVGRSGTFCAIY
. ...   .. |.|.|.  .|.  .  |.||. .. |   .||.|.. ..|||   | . ...| .|. |.  |.      ||| || |.|||||. .|.
sknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrsGtlitid

SLLERIKAEQVVDVFQTV
 .|. |. .. .|| ..|
vvlglierdkefdvkeiv
0049260 (Phosphotyrosine protein) phosphatases II 916-1101 1.1e-37 124.5 In-house 7-143 (152) alignment 
Range on Protein: 916-1101
Range on HMM: 7-143/152.0
RPAPFVPCKRPLPVTVADFWQLVWQEQVTTIVMLTNIVEVGKTKCHRYWpegkarhgefdislhreevfadyvvrtfiikkdegqsrqvvQFQYTSWPDK
.| .|...  |.| |.||||..... ..|||||||. .| || ||..|.                                         |.... ||| 
mpfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.........................................qylhlpwpDh

GVPRHATSVLGFRRKVRAHytSRNGQVPMLVHCSAGVGRTGAFIAIDAMLerakkeKTVDIHNYVNVMRNNRCTMIQTEDQYAFVH
||| ..  .| . . .. .   .. . | ||||||||||||...|.. ||      . |.. ..|. .|. |  ......|. |..
gvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_PTPN1_pd Subfamily PTPN1 1152-1357 1.6e-37 123.8 In-house 18-232 (290) alignment 
Range on Protein: 1152-1357
Range on HMM: 18-232/290.0
QIEDENSKVGRADYNIKKNRYPSVVPLDSSRVVLSVDGGDYINASFADAFRKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQED-TLTYPQYW
. .| . .. . . | ..|||  | | | ||..|  .  ||||||. .. . .  .|||| || .|.. ||.|. . |  ..||||.. |  ..   |||
easdfptreaklpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqyw

PSKGS---ETYD--HLNVRLMSREKQGKLISRKLAIGQKVSE--HEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQCGDK-AIVVQCSNGVGRSGT
|.. .    ...  .|.|.|.|.|.. . . |.| . .. ..  .|..|  .. |||   |   .. |...  |. |     |.   |. || |.|||||
PqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGt

FCAIYSLLERIKAEQ
|| . ..| .|....
fclvdtclvliekkd
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 858-1107 2.4e-37 123.6 In-house 35-276 (307) alignment 
Range on Protein: 858-1107
Range on HMM: 35-276/307.0
VARRRDNKKRNRYANIIAYDHSRVRLR-DNQESDYINASYLHVkpwrnaegipsvccVQRPAPFVPCKRPLPVTVADFWQLVWQEQVTTIVMLTNIVEVG
|   . | ..||| .. . |..|. .. |   |||| | || .                .|  |. .. ||  |. .|| .. ||.| ...|| ...|..
veafsantdknryqdvkcqdkgrivvkfdglasdyihanylgi..............aikpkkficaqgplentqysfwamaiqekvesvimlckviela

KTKCHRYWPEGKARHGEFD-----ISLHR---EEVFA-DYVVRTFIIKKD-EGQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVrahytsRNGQVPMLV
| ||..|||  . ..  |      ||.     ...   . ..    .| |  ..|| . ..|.. |||.|||.   . . .   |      |  . |..|
kikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleav......rydtnpvvv

HCSAGVGRTGAFIAIDAMLERA-KKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEA
||||||||.|. .||  . ..  . .   |... |. .|..|   |||| || ..|  .|| 
hcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley
0043147 (Phosphotyrosine protein) phosphatases II 887-1101 3.7e-37 123.0 In-house 3-154 (172) alignment 
Range on Protein: 887-1101
Range on HMM: 3-154/172.0
QESDYINASYLHVKPwrnaegipsvccvqRPAPFVPCKRPLPVTVADFWQLVWQEQVTTIVMLTNIvevgktkchrywpegkarhgefdislhreevfad
. |||||||||..                 |  |...  ||. |.||||........|.||.||.                                   
egsdyinasyldlyy..............ipdrfiatqgplrntladfwrmlkelgithivnltel..................................

yvvrtfiIKKDEGQSRQVVQFQYTSWPDKGVPrHATSVLGFRRKVRAHYtSRNGQVPMLVHCSAGVGRTGAFIAIDAMLerakkeKTVDIHNYVNVMRNN
        .  |. .|...|..|..||| ||| ..  .| | . .. ..  .. . |.||||||||||||...|.. ||      . ..... |. .|. 
.......lydpellerlgiqylylpwpDhgvp.llellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrek

RCTMIQTEDQYAFVH
|. ..|...|| |..
Rpgavqnpsqyrfly
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 864-1106 1.2e-36 120.9 In-house 55-287 (305) alignment 
Range on Protein: 864-1106
Range on HMM: 55-287/305.0
NKKRNRYANIIAYDHSRVRLRDNQESDYINASYLhvkpwrnaeGIPSVCCvQRpapFVPCKRPLPVTVADFWQLVWQEQVTTIVMLTNIVEVGKTKCHRY
.. .|||... . |.| |.| . . |||| | |.         | | .   .|   |. .. ||  |. .|| .| |..|  |||| . ||.|| || .|
aitknryqdvpcqdqsavkldkpspsdyihanyv.........gcpmipe.kr...ficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqy

WPEGKARHGEFDISLHREEVFA--------DYVVRTFIIKKDEGQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRahytsrNGQVPMLVHCSAGVGRT
||  .  . |.   .  |.|          .  . .. .    .|.  | ..|.| |||.|||    . | .   .|        .||..||||||.|||
wpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsair......gskvpivvhcsagigrt

GAFIAIDAMLERAKKEKT-VDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLE
|. .||. .||.  ..|    . . |. .|..|.  ||.. || |.|  .|.
gtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln
0046846 (Phosphotyrosine protein) phosphatases II 920-1106 3.5e-36 120.0 In-house 25-171 (176) alignment 
Range on Protein: 920-1106
Range on HMM: 25-171/176.0
FVPCKRPLPVTVADFWQLVWQEQVTTIVMLTNIVEVGKTKCHRYWPEGKARHGefdislhreevfadyvvrtfiikkdegqsrqvvQFQYTSWPDKGVPR
.. .  ||| |.|||.........|..|.||. || |. ||..|||| .. .                                  |.... ||| ||| 
piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.................................qylhlpwpDhgvpd

HaTSVLGFRRKVRAHYTSRngqVPMLVHCSAGVGRTGAFIAIDAMLErakkEKTVDIHNYVNVMRNNRC-TMIQTEDQYAFVHFAVLE
. . .| . . .| ....     | |||||||.||||...|.. .      || ..... .  .|. |.  ..||..|| |.. ..|.
l.elllellefirealkeg...gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpeQyrflyefell
0041856 (Phosphotyrosine protein) phosphatases II 1166-1360 3.6e-35 116.6 In-house 1-144 (182) alignment 
Range on Protein: 1166-1360
Range on HMM: 1-144/182.0
NIKKNRYPSVVPLDSSRvvlsvdGGDYINASFADAFRKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNnlqedtltYPQYWPSKGsetydhlnvrl
|..||||. ..| | ||      . |||||.. .  .. . ||.||.|| .|.|.|..|. ...|.|||.|.         ..|||..            
nldknrysdilpydhsr......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt........eelywpell...........

msrekqgklisrklaigqkvsEHEVVHIQHIEWPDKCAPVnHQSVLDLVSWVQLsqqqcGDKAIVVQCSNGVGRSGTFCAIYSLL-ERIKAEQVVD
                     |......... ||| ..|   ...||.. .|.       .....| || ||||.||..|.| ..  .. .|..|.
.....................erlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 986-1122 2e-34 113.7 In-house 76-208 (440) alignment 
Range on Protein: 986-1122
Range on HMM: 76-208/440.0
DYVVRTFIikkDEGQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAHyTSRNGQVPMLVHCSAGVGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRN
||.  ..|   .  .|| . |..| .|||||||. |  || . . |      . |. |.|||||||.||||  ||.|..|  ||.   .|| ...| |||
dyinasyi...ngiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnes.qekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrn

NRCTMIQTEDQYAFVHFAVLEALTCGNTEIEAGNLQI
||  |.|| .|||||| ||||.| ||.| |   ..  
nrpqmvqtpeqyafvheavlegllcgdtlileddite
0036282 (Phosphotyrosine protein) phosphatases II 1189-1365 3.9e-34 113.2 In-house 1-142 (174) alignment 
Range on Protein: 1189-1365
Range on HMM: 1-142/174.0
GGDYINASFADAFRKRNAFILTQAPLEhtmaeFWHMICQYKIGTIVMLNNLQEDT-LTYPQYWPSkgsetydhlnvrlmsrekqgklisrklaiGQKVSE
| ||||||. | ..  . .|..|.||.     ||.|.....| |.|||....|.     ..|||.                              ..  |
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.............................lredle

HEVVHIQHIEWPDKCAPVNHQsVLDLVSWVQLSQQQCGDKAIVVQCSNGVGRSGTFCAIYSLLERIKaEQVVDVFQTV
......... ||| ..|  .. .|..|..|.  ....... ..| || ||||.||..|.| .| ... | .||....|
rlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlv
subfamily_PTPRN_pd Subfamily PTPRN 1152-1364 5.3e-34 112.3 In-house 42-263 (297) alignment 
Range on Protein: 1152-1364
Range on HMM: 42-263/297.0
QIEDENSKVGRADYNIKKNRYPSVVPLDSSRVVLSV----DGGDYINASFA-DAFRKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQEDTLT-
. |.. ..|..|. |.||||. .|.| | ||| |.     .  ||||||.  |   .. |.| ||.|| .|.|.|| |. .  .  ||.| .|.|. .. 
eaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkq

YPQYWPSKGSETYDHLNVRLMSREKQG-KLISRKLAI--GQKVSEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQcGDKAIVVQCSNGVGRSGT
  .||| .|||.|.  .|.|.|        . | . .   |.     |    .. ||.. .| . .|.|..   |. | .     .||| ||.|.||.|.
ckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG.rscpivvhcsdGaGrtGv

FCAIYSLLERI-KAEQVVDVFQT
...|  .|.|. |  . .|.  |
yilidlvlnrllkGvkeidiaat
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 863-1106 6.3e-34 112.1 In-house 47-285 (305) alignment 
Range on Protein: 863-1106
Range on HMM: 47-285/305.0
DNKKRNRYANIIAYDHSRVRLRDNQESDYINASYLHVkpwrnaegiPSvccvqRPAPFVPCKRPLPVTVADFWQLVWQEQVTTIVMLTNIVEVGKTKCHR
.....||| ..   |. ||.|.     .|| | |.           |.      |  |. .. ||  | |||| . .|..| .| || |..| |  ||. 
qeagknrykdvgcldnnrvklegpwpheyihanyvst.........pt.....npkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcle

YWPEGKARHGEFD-----ISLHREE---------VFADyVVRT-FIIKKDEGQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAHytsrngQVPMLVH
|..  .    ||.     ||.. |            |. | .| ..|.   ...|.| .. .  |||.|||   ...| .  | |.       . |. ||
yfaskdkdvlefeekgqkisvkfessvtlkfrkdakak.vtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarps......kgpivvh

CSAGVGRTGAFIAIDAMLERAKKEKTVDI-HNYVNVMRNNRCTMIQTEDQYAFVHFAVLE
||||.||||. . .. .|..    . ..  .  .. .|..|   |||..|| |||  .|.
csagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 864-1109 7.8e-34 112.0 In-house 43-272 (288) alignment 
Range on Protein: 864-1109
Range on HMM: 43-272/288.0
NKKRNRYANIIAYDHSRVRLRDNQEsDYINASYLHvkpwrnaegipsvcCVQRPAPFVPCKRPLPVTVADFWQLVWQEQVTTIVMLTNIVEVGKTKCHRY
|  |.|| |.   | .||.| |. .  ||.|  .               . . .  .. .. || .|.  .|... ...|  ||||....| || |   |
nptrdryenlprcditrvklsddpd.fyiaanvvs..............sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaey

WPEG---KARHGEFDISLHREEVFADYVVRTF-IIKKDEGQSRQ-VVQFQYTSWPDKGVPRHATSVLGFRRKVrahytsRNGQVPMLVHCSAGVGRTGAF
.|     ||| | .     .. .  | .|.   .  . ||. .. | .  .  |.|.|||    | | .   .      .. | |..||.||||||||..
fPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl......kslqkPivvhssaGvGrtgtl

IAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEALT
| |  .|| .. .  . |.. .. .|..|   |||| || .||  ||| | 
ililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleell
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1156-1364 8.8e-34 111.7 In-house 10-235 (270) alignment 
Range on Protein: 1156-1364
Range on HMM: 10-235/270.0
ENSKVGRADYNIKKNRYPSVVPLDSSRVVLSVD----GGDYINASFADAF-RKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQEDTLT-YPQY
..|..  |  . | |||  ..|   .||.|.         |||| .   |  .....| ...||. |. .|| || . |  .|||. .|.|.  .   .|
sesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerY

WPSKGSE----TYDHLNVRLMSREKQGKLISRKLAIGQKVSEHEVVHIQHIEWPDKCAPVNHQ------SVLDLVSWVQLSQQQCGDK-AIVVQCSNGVG
||..  |    .. ...|. .| ||.   | ..| . .| .|...|| .. .|||. .| ...      ..| ..  |. |...  ..  ..| ||.|||
WpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvg

RSGTFCAIYSLLERIKAEQVVDVFQT
|.||. |.   .. .. .. ||| . 
RtGtlialDiavrlLeetkkvdvlai
subfamily_ptpA1_pd Subfamily ptpA1 861-1067 1e-33 111.7 In-house 44-255 (418) alignment 
Range on Protein: 861-1067
Range on HMM: 44-255/418.0
RRDNKKRNRYANIIAYDHSRVRLR---DNQESDYINASYLHvkpwrnaeGIpsvccvqRPAPFVPCKRPLPVTVADFWQLVWQEQVTTIVMLTNIVEVGK
.. |  .|||.||.  .|.||.|.   |.. |||||| |.         |         |  |.  . ||| |.||||..||....  ||||.   |  .
kkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyid........ga.......ypkqfictqgplpntiadfwrmvwenrcriivmlsresencr

TKCHRYWPEGKArHGEFDISLHREEVFADYVVRTFI---------IK-----KDEGQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKV----RAHYTSRN
 || |||||      .| |    .|||  | |             |        ||..|.. |.||  |||. .| |.  .  . . .         | .
ikcdrywpeqig.geqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssd

GQVPMLVHCSAGVGRTGAFIAIDAMLER
 .||..|||||||||||.| .   |...
rnvpiivhcsagvgrtgtfctavimmkk
0043147 (Phosphotyrosine protein) phosphatases II 1188-1363 2.2e-33 110.8 In-house 3-137 (172) alignment 
Range on Protein: 1188-1363
Range on HMM: 3-137/172.0
DGGDYINASFADAFRKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLqedtltypqywpskgsetydhlnvrlmsrekqgklisrklAIGQKVSE
.| ||||||. |  .. . || ||.|| .|.|.||.|. ...|..||.|..|                                            .  |
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel........................................lydpelle

HEVVHIQHIEWPDKCAPvNHQSVLDLVSWVQLSQQQCGDKAIVVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQ
......... ||| ..| . . .|.......  .... .....| || ||||.||..|.| .|.....|..|. ..
rlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylmllglsleeavalvr
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1157-1364 3.2e-33 109.7 In-house 36-207 (392) alignment 
Range on Protein: 1157-1364
Range on HMM: 36-207/392.0
NSKVGRADYNIKKNRYPSVVPLDSSRVVL----SVDGGDYINASFADAFRKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQEDTltypqywps
. .|.. . |.|||||  ..|.||.||.|     .   ||.|||. ..|   .|.| .|.|   .. .||.|. | .. ||.|...|.|           
pqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.........

kgsetydhlnvrlmsrekqgklisrklaigqK-VSEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQCGdKAIVVQCSNGVGRSGTFCAIYSLLE
                               |  . . |   .  |||||  |    |.| ..  |.    |   . ....|| ||||.|   .| |.. 
...............................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqyt.hpliihcsagvgrtgvvisidsvva

RIKAEQVVDVFQT
. |  ..||||. 
hakktrmvdvfnf
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1162-1361 3.6e-33 109.7 In-house 44-247 (439) alignment 
Range on Protein: 1162-1361
Range on HMM: 44-247/439.0
RADYNIKKNRYPSVVPLDSSRVVL----SVDGGDYINASFADAFRKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQEDTLtypqYWPSKGSET
  .|.  |||| .|...| .||.|     |    |||| . . . . . .| ||.| ..|  .|| .. . |  ||||| || |       ||||..   
aqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk....ywpsdaevc

YDHLNVRLMSREKQGKLISRKLAIGQKV----SEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQCGDKAIVVQCSNGVGRSGTFCAIYSLLERI
|  . ||     .  . . | . . ..      |. |.....| ||||  | .   |||..  .. ....     .||.|| ||||.||  |.   ||..
ygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeql

KAEQVVDV
|.|. ||.
klenkvdi
PTPc_DSPc_SM00012 1003-1105 8.6e-33 108.1 In-house 1-104 (105) alignment 
Range on Protein: 1003-1105
Range on HMM: 1-104/105.0
QVVQFQYTSWPDKGVPRHATSVLGFRRKVRAHYTSRNGQVPMLVHCSAGVGRTGAFIAIDAMLERAKKE-KTVDIHNYVNVMRNNRCTMIQTEDQYAFVH
.| ...||.|||.|||....|.| . |.|. ... .. . |..||||||||||| |.|.| .|.. .|| |.||| ..|. .|. | .|.|||.|| |..
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

FAVL
 |.|
rall
0051082 (Phosphotyrosine protein) phosphatases II 889-1105 2.3e-32 107.0 In-house 3-150 (151) alignment 
Range on Protein: 889-1105
Range on HMM: 3-150/151.0
SDYINASYLHvkPWrnaegipsVCCVQRPAPfvpckrplpvtvaDFWQLVWQEQVTTIVMLTNIVEVGktKCHRYWPE-Gkarhgefdislhreevfady
|||||.||.   .         . . . | .             ||..|.......|||.|.. .| |  .|..|.|| |                    
sdyinfsyvt..gg........lyrsggpla.............dflellkelgiktivnlrseeerg..ycpeylpelg....................

vvrtfiikkdegqsRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAhytsrNGQVPMLVHCSAGVGRTGAFIAIDAMLERakkektVDIHNYVNVMRNNR
              ..|.......||| |.| .  .|| | .....     ... |.|||||||.||||...|.. ||..      |..   .. .|  |
..............ievlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkr

CTMIQTEDQYAFVHFAVL
. ..|...|. |..||.|
pgvvqpnqqflfqlfall
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1133-1352 3.8e-32 106.1 In-house 23-242 (290) alignment 
Range on Protein: 1133-1352
Range on HMM: 23-242/290.0
TQNLSGYALEYQRLLAVSSQIEDENSKVGRADYNIKKNRYPSVVPLDSSRVVLSVD-GGDYINASFADAFrkRNAFILTQAPLEHTMAEFWHMICQYKIG
 .|  ..| ||   |      .  . |.  .. ..|||||  ||  | .||.|.    |||. | . .    .  ||||| .|. |. ..| |. | |. 
kknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekva

TIVMLNNLQEDTLT-YPQYWPSKGSE--TYDHLNVRL-MSREKQGKLISRKLAIGQKVS--EHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVqlsQQQCG
.|||| .| ||  .   ||.| |  |  |. .. |   .. .|. ..| . |.. .| |  || . |.. . ||||. .    ..| ..  .   ..  |
aivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlril...rkasG

dkAIVVQCSNGVGRSGTFCAIYSLLER
   .|| || |.||.||| ||   |. 
..pvvvhcsaGiGrtGtfvaievglqi
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 862-1105 1.1e-31 104.6 In-house 35-266 (281) alignment 
Range on Protein: 862-1105
Range on HMM: 35-266/281.0
RDNKKRNRYANIIAYDHSRVRLRD---N-QESDYINASYLHVkPWrnaegipsvccVQRpaPFVPCKRPLPVTVADFWQLVWQEQVTTIVMLTNIVEVGK
  |.|.|||.|| . | |||.|.    | . .||| | |..  |.           ..|   ..  . |   | ||||...|||. |.|||| ...|  .
pvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirs.pf...........lkr..gyiltqgpkketradfwrmiwqenttaivmlcqfletnr

TKCHRYWPEGKARHGEFD-ISLHREEV-FADYVVRTFIIKKDEGQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAHYTsrngqvPMLVHCSAGVGRT
 ||  |.|       .|| .|.  |.      .| | .    ||..| . .. .  |||  ||  .  .|   ||.||. |      | ..||||||||.
ekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirarst......ppvihcsagvgrs

GAFIAIDAMLERAKKEKTV-DIHNYVNVMRN-NRCTMIQTEDQYAFVHFAVL
|...|..  |.  .   |. ||.. |  .|   |.. .|| .|| ..   .|
gtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvll
0049772 (Phosphotyrosine protein) phosphatases II 854-1111 6e-31 103.7 In-house 36-283 (314) alignment 
Range on Protein: 854-1111
Range on HMM: 36-283/314.0
FTWEVARRRDNKKRNRYANIIAYDhSRVRL--RDNQESDYINASYLHVKpwrnaegipsvccvqrpAPFVPCKRPLPVTVADF----------WQLV--W
.|. ||.   |...||| .|. .| .||.|   ... ||||||||..                     |. .. ||..|| ||          |..|  .
ltilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf.................lkfIatqgpleitvvdfreepvlyyngwrmvlrg

QEQVTTIVM---------------------LTNIVEVGktkchrywpegkARHGEFDISLHReevfadyvvrtFIIKKDEGQSRQVVQFQYTSWPDKGVP
. .| .|||                     |... . |            .   . |. |..            ..  .|  .|..... .. .|| ..|
dlnvrdivmsrdevladelsrLdaAlgKtpllildgng............neptaadlellk...........eelydpelferlgikylripvpDgsap

rHATSVLGFRRKVRAHytsrNGQVPMLVHCSAGVGRTGAFIAIDAMLERAKkektVDIHNYVNVMRNNRC-----TMIQTEDQYAFVHFAVLEALTCG
     .. | . ....    . . | ||||.||.|||| |.... .. . .    |...  .. .|. |       .|.. .|| |.. |.||.|   
.lledfdeflefieea....dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefilealleylkfl
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1162-1365 7.6e-31 102.0 In-house 34-249 (287) alignment 
Range on Protein: 1162-1365
Range on HMM: 34-249/287.0
RADYNIKKNRYPSVVPLDSSRVVLSVD---GGDYINASFADAFRKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVML-NNLQEDTLTYPQYWPSKGSET
   ...|||||  |.|.| .||.|| .   | ||||| .  .... .||| .|.|.  |. .|| .. . .  .....  ...|  |   .||| .    
eelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPm

-YDHLNVRLMS-REKQGKLISRKLAIGQKVSEH-EVVH-IQHIEWPDKCAPVN----HQSVLDLVSWVQLSQQQCGDKAIVVQCSNGVGRSGTFCAIYSL
      | |..   |. .   | | . .  ... .||. .. ..|||| ..       . |||    ..|...  .   .|| .. |.||||.. |.. |
rvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvl

LERIKAEQVVDVFQTV
..| .    ||| ..|
vsrledlGrvdvaavv
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 856-1031 3.2e-30 100.0 In-house 25-193 (297) alignment 
Range on Protein: 856-1031
Range on HMM: 25-193/297.0
WEVARRRDNKKRNRYANIIAYDHSRVRLRD-NQESDYINASYLHVkPwrNAegipsvccvQRPAPFVPCKRPLPVTVADFWQLVWQEQVTTIVMLTNIVE
. .|.|    ..||| .|.|.| .||.|.    |.||||| |.   |  .          . .  ..  . ||  || |||.||....| .|||.... |
fssakrnsslrknryrdilatddtrvkllrviterdyinadyvvf.p..de.........eadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqe

VGKTKCHRYWPEG---KARHGEFD---ISLHREEvFADYVVrTFIIKKDEGQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKV
 |. ||  |||.    . . |..    .|   .| |   .. | .      .||.|   |. ||||.|||     .  |. .|
dGrdkcapywpsvvqerlkagdvvveflsstsde.fdrvil.telqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqv
0051429 (Phosphotyrosine protein) phosphatases II 1188-1364 3.4e-30 101.0 In-house 2-196 (272) alignment 
Range on Protein: 1188-1364
Range on HMM: 2-196/272.0
DGGDYINASFADAFRK---RNAFILTQAPLEHTMAEFWHMiCQYKIGTIVMLNNLQEDTLTY-PQYWP------------SKGSETYDHLNVRLMSREKQ
. ..||||.. . . .   .........||..| |.||.. ....| |||.| .. |      ..|||            |  . .| .| |.|.| | .
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

GKLISRKLAIG---QKVSEHEVVHIQHIEWPDKCAPVNHqsVLDLVSWVQLsqqqcgDKAIVVQCSNGVGRSGTFCAIYSLLERIKAEQVVD--------
   | |.| .    .    .|| |.... ||| ..| .   .|.|.....       .....| || |..|.||..|.. ||... .|..||        
ldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly

VFQT
....
leea
0049772 (Phosphotyrosine protein) phosphatases II 1160-1352 4.4e-30 100.9 In-house 40-238 (314) alignment 
Range on Protein: 1160-1352
Range on HMM: 40-238/314.0
VGRADYNIKKNRYPSVVPLDsSRVVL---SVDGGDYINASFADAFrkrNAFILTQAPLEHTMAEF----------WHMI--CQYKIGTIVM---------
|..   |..||||. ..| | .||.|   .|.| ||||||. | |   ..|| ||.|||.|.  |          |.|.   .... .|||         
vadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlade

------------LNNLQEDTltypqywPSKGSETYDHLNvrlmsrekqgklisrklA-------IgqkvsEHEVVHIQHIEWPDKCAPvNHQSVLDLVSW
            |..| . .       .    .....|.                               |.....  .| .|| .||   . ..... .
lsrLdaAlgKtpllildgng.......neptaadlellk.................eelydpelf.....erlgikylripvpDgsap.lledfdeflef

VQLSqqqCGDKAIVVQCSNGVGRSGTFCAIYSLLER
..       .....| |. |.||.|||.... |. .
ieea...dkggpvlvHCkaGkgRtgtfvvaaylmkl
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 864-1108 5.2e-30 99.4 In-house 35-270 (285) alignment 
Range on Protein: 864-1108
Range on HMM: 35-270/285.0
NKKRNRYANIIAYDHSRVRLRdNQESDYINASYLHVkPWRNAegipsvccvqrpAPFVPCKRPLPVTVADFWQLVWQEQVTTIVMLTNIVEVGKTKCHRY
|   ||||.. . . .|| |. |.. ||| ||.... | ..             . ..  . ||| |..|||....||... ..||  ..| |  ||  |
npdlnryadvrcieetrvvlk.nhdrdyihaswmrm.pgkdq............styittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcaly

WPEGK---ARHGEFDISLH--REEVFADYVVRTFIIKKDEGQSRQV---VQFQYTSWPDKGVPRHATSVLGFRRKVRAHytsRNGQVPMLVHCSAGVGRT
.||      . |...|.|   .||  |  .. .. . . |  | .     . |   |||.  |  |  .. . . |.        . |. ||||||||||
ypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkv...npkekpicvhcsagvgrt

GAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEAL
 .|. ||    |  ..  ... . |  ||  |   .|.  |. |..  ..| .
atfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_PTPN14_pd Subfamily PTPN14 1150-1362 6.8e-30 99.1 In-house 33-265 (300) alignment 
Range on Protein: 1150-1362
Range on HMM: 33-265/300.0
SSQIEDENSKVGRADYNIKKNRYPSVVPLDSSRVVLSV---DGGDYINASFADAF--RKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQEDTL
. . || . .... . | .|||.. |.| . .|| ||    .  .|||||   .    |.  .| .|.|||.|. .||.|. . ..  |||| . .||  
pkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgk

TY-PQYWPSKGS----ETYDHLNVRLMSREKQGKLISRKLAIGQKVS--EHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQCGDK--------AI
.   .|.|...|     .... .|    .|. ...| ..| .    |  | .|.|.|...|||.  | . .. |. .  ||  ...  ..         .
eksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPv

VVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVF
.| ||.||||.|       |.. .. ....|. 
lvhCsaGvGrtGvlilsdlliatlehneeidik
0044763 (Phosphotyrosine protein) phosphatases II 884-1103 6.9e-30 99.4 In-house 13-166 (178) alignment 
Range on Protein: 884-1103
Range on HMM: 13-166/178.0
RDNQESDYINASYLHvkpwrnaegiPSVCCVQRPApfvpckrplpvtvADFWQLVWQEQVTTIVMLTNIVEVGKTKCHRYWPEGKArhgefdislhreev
.. . |||||||.            | .   . |.             ||...|.... .|.||.||. .| |. ||..||||.                
eglersdyinaseil..........pglylgslpp.............addlellkelgithivnlteelelgflkcdpywpeeag..............

fadyvvrtfiikkdegqsrqvVQFQYTSWPDKGVPRHATSVLGFRRKVRAHYTSRNGqvPMLVHCSAGVGRTGAFIAIDAMLERakkekTVDIHNYVNVM
                     .|.... .|| |||     .| | . ..... ...|  | ||||||||||.|...|.. |...      ..... .. .
.....................iqylhipipDhgvpdllehflefvefieealdekgg..pvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielv

RNNRCtMIQTEDQYAFVHFA
|. |. ......|. ...  
rerRp.ivpnpgqlrqLyef
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1166-1364 1.8e-29 97.7 In-house 3-210 (237) alignment 
Range on Protein: 1166-1364
Range on HMM: 3-210/237.0
NIKKNRYPSVVPLDSSRVVLSVDG--GDYINASFADAFRK-RNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQE-DTLTYPQYWPSKG-SETYDH
|  |||| ..|  | |||||   |   |||||.. . |    . .| .| ||| .  .|| |. | |   ||||  | | . |   .||||    ..|  
nkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygv

LNVRLMSREKQGKLISRKLAIGQKVSEHEVVHI---QHIEWPDKCAPVNHQSVLDLVSW-VQLSQQQCGDKAIVVQCSNGVGRSGTFCAIYSLLERIKAE
| | |  .|.      | | . .... .||  |   |   |||.  | .  ..| .    .. |.        .. || ||||.| |  | ..| . | .
ltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakek

QVVDVFQT
.|||... 
kvvdiyny
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 916-1102 8.5e-29 95.2 In-house 88-275 (301) alignment 
Range on Protein: 916-1102
Range on HMM: 88-275/301.0
RPAPFVPCKRPLPVTVADFWQLVWQEQVTTIVMLTNIVEVGKTKCHRYWPEG---KARHGEFDISLHRE-EVFADYVV-RTFIIKKDEG--QSRQVVQFQ
.|  |.  . ||. |  ||| .. | .| .||||.. ||  ..||. | |     | . | |.| .. .  .. . .. ||. ..   |  ..| |. .|
hphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyq

YTSWPDKGVPRHATSVLGFRRKVRahytsrNGQVPMLVHCSAGVGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHF
|..|.|.|||.  . .  .   |.      . . |..||||||.||. |||. . .  . . ..|... . .. .|..| . .||. |  .. .
ysewtdrgvPkshaelfdlmelvk......ksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlywmtl
0049260 (Phosphotyrosine protein) phosphatases II 1199-1363 2.2e-28 94.3 In-house 3-126 (152) alignment 
Range on Protein: 1199-1363
Range on HMM: 3-126/152.0
DAFRKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQEDTLT-YPQYWpskgsetydhlnvrlmsrekqgklisrklaigqkvsehevvHIQHIE
| ... ..|| ||.|...|.|.||.|. ...|.|||||..|.|..    .||.                                         ...|. 
dgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.........................................qylhlp

WPDKCAPVNHQSVLDLVSWVQLSqQQCGDKAIVVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQ
||| ..| ..| .|.|. ...   ..  .. ..| || ||||.||..|.| .| ....|..|. ..
wpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylmllgvsleeavalvr
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1165-1364 9e-28 92.0 In-house 7-212 (239) alignment 
Range on Protein: 1165-1364
Range on HMM: 7-212/239.0
YNIKKNRYPSVVPLDSSRVVL---SVD-GGDYINASFADAF-RKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQEDT-LTYPQYWPSKGSeTY
 |  ||||  .|  | |||||   | |   ||||||.   .    .|.| ||  .| .  .||.|. | .   ||||  | |       ||||   |  |
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.ky

DHLNVRLMSREKQGKLISRKLAIGQKV--SEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQlSQQQCGDKAIVVQCSNGVGRSGTFCAIYSLLERIKAE
  | | |   |     | | . . |     |. | . .   ||||  |    .|| |   .   .   | .  |..|| ||||.|.|  | ..| . | .
cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkit.kdslpgarpwvihcsagvgrtgaflvidamlrqakkq

QVVDVFQT
. ||.|. 
ktvdifny
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1166-1364 9.5e-28 91.9 In-house 7-211 (239) alignment 
Range on Protein: 1166-1364
Range on HMM: 7-211/239.0
NIKKNRYPSVVPLDSSRVVL---SVD-GGDYINASFADAF-RKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQEDT-LTYPQYWPSKGSeTYD
|  ||||  .|  | |||||   | |   ||||||.   .    .|.| ||  .| .  .||.|. | .   ||||  | |       ||||   |  | 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.kyc

HLNVRLMSREKQGKLISRKLAIGQKV--SEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQlSQQQCGDKAIVVQCSNGVGRSGTFCAIYSLLERIKAEQ
 | | |   |     | | . . |     |. | . .   ||||  |    .|| |   .   .   | .  |..|| ||||.|.|  | ..| . | ..
nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkit.kdslpgarpwvihcsagvgrtgaflvidamlrqakkqk

VVDVFQT
 ||.|. 
tvdifny
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1162-1362 1.3e-27 91.3 In-house 46-250 (301) alignment 
Range on Protein: 1162-1362
Range on HMM: 46-250/301.0
RADYNIKKNRYPSVvPLDSSRVVLSVDGGDY--INASFADAFRKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQEDT-LTYPQYWPSKGSETY
 |  . .|.|||.| | . |  |  .. |    | | . ..  . . || ||.||. |. .|| |. ||.. .|||| .  |..     .| |.| ||. 
yaylpkdkhryptv.PckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekl

D--HLNVRLMSREK--QGKLISRKLAIG---QKVSEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSqqqcgDKAIVVQCSNGVGRSGTFCAIYSLLE
|    .... ..|.  . |.. |.| .    .|.. . |.| |. ||.|.  |  |  . ||.  |. |     .| |||.||.|.||| .| .   |  
digrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkks.....ekPivvhcsaGiGrsvafigteylar

RIKAEQVVDVF
...|.. ... 
eveadptielt
0046846 (Phosphotyrosine protein) phosphatases II 1190-1362 1.4e-27 92.0 In-house 12-147 (176) alignment 
Range on Protein: 1190-1362
Range on HMM: 12-147/176.0
GDYINASFADAFRkrnaFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQEDTLTY-PQYWPSKGSETYdhlnvrlmsrekqgklisrklaigqkvseh
 |||||....  |    .| ||.||..|.|.|..|. ...|...|.|....|      |.|||   .. .                              
ldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..............................

evvHIQHIEWPDKCAPVNhQSVLDLVSWVQLSQQQcgDKAIVVQCSNGVGRSGTFCAIYSLLE--RIKAEQVVDVF
   ...|. ||| ..|   . .|.|. ...  ...  .. ..| || |.||.||..|.| |     ...|.... .
...qylhlpwpDhgvpdl.elllellefirealke..ggpvlVHCsaGigRtgtlvaayllelekglsveealalv
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1166-1359 3.4e-27 90.2 In-house 43-237 (288) alignment 
Range on Protein: 1166-1359
Range on HMM: 43-237/288.0
NIKKNRYPSVVPLDSSRVVLSVDGGDYINASFADAFRKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQEDTLTY-PQYWPSKGSETYDHL---
|  ..||  .   | .|| || |   ||.|    . . .. .| .||||. |. |.|.|. .  .  ||||..| |  .    .|.|||  |.       
nptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlc

NVRLMSREKQGKLISRKLAIGQKVSEHEV--VHIQHIEWPDKCAPVNHQSVLDLVSWVqlsqqQCGDKAIVVQCSNGVGRSGTFCAIYSLLERIKAEQVV
.|   .|.   ||..  |   .|. |..|   ..   ||.|.. | |..| | |.  .     .  .| |||..|.||||.||.  |   || .. .  .
tvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililialeslrlddfl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1159-1352 3.5e-26 86.9 In-house 34-235 (307) alignment 
Range on Protein: 1159-1352
Range on HMM: 34-235/307.0
KVGRADYNIKKNRYPSVVPLDSSRVVLSVDG--GDYINASFADAFRKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQED-TLTYPQYWPSKGS
 |   . | .||||  |   | .|.|. .||   ||| | .     | . || .| ||| |. .|| |. | |. ...|| .. |   .   |||| .  
tveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleeg

ET-----------YDHLNVRLMSREKQGK-LISRKLAIGQKvsEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQqqcgdKAIVVQCSNGVGRSGTF
..            . | .. .. ...   . . |.  .||     . |.|  .|||. .|    . ..|.. |.  .       .|| || ||||||| 
qklvfgeapntisvanlgakklapdedlinvttlkvdwaqk..srtiqhlqwenwpdrgvpqinltainlleavrydt.....npvvvhcsaGvGrsGti

CAIYSLLER
 ||  . ..
vaislvqdk
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1163-1356 6.3e-26 85.7 In-house 52-251 (305) alignment 
Range on Protein: 1163-1356
Range on HMM: 52-251/305.0
ADYNIKKNRYPSVVPLDSSRVVLSV-DGGDYINASFADAF-RKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNL-QEDTLTYPQYWPSKGSETYD
|| .| ||||  |   | | | |.     ||| | .  .     . || .| ||..|. ||| |. | |.  |||| .  .   |   ||||    |  .
adiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

HL---------NVRLMSREKQGKLISRKLAI--GQKVSeheVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQqqcgdKAIVVQCSNGVGRSGTFCAIYS
             . | |. . ..   .|.   .||.|   | |.|  ||||.  |  . . |.|.| .. |.       |||.|| |.||.||  ||  
lksgivvenvsgskpmerdaeiqitllnltysgdqkms...vrhlqwtewpdrgvppckltslellsairgsk.....vpivvhcsagigrtgtivaiey

LLERIKAE
.||.|  .
ilekiaen
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 850-1117 1.1e-25 84.9 In-house 38-298 (310) alignment 
Range on Protein: 850-1117
Range on HMM: 38-298/310.0
SGQQFTWEVARRRDNKKRNRYANIIAYDHSRVRLRD--NQESDYINASYLHVKPWRNAegipsvccvqrpapFVPCKRPLPVTVADFWQLVWQEQVTTIV
. |. .      ... ..|||....  | |||.|.    .  ||| | |.. .  |..              |. .. ||  |. |||....||.  .|.
akqdssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrst..............ficsqgplqhtiidfwrmifqeraesil

MLTNIVEVGKTKCHRYWPE-------GKARHGEFDISLHREEVfaDYVVRTFII---KKDEG----QSRQVVQFQYTSWPDKGVPRHATSVLGFRRKvrA
.| ...| |. ||  |||        |  |  ..  | .  |.    .  ||.      ||     .  .|   ..  |||.|||      .  |    |
llckvgeegrpkcvgywpslgvtetygcirvtnlsesseefei..cnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrll..a

hyTSRNGqvPMLVHCSAGVGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLeALTCGNTEIEA
    | |  | .||||||..|... .|..  ...... . ||... .  ....|   |||| || ....  . ... |.||.  
..qvrhg..pcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvri.ifargetevae
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1164-1358 1.5e-24 81.5 In-house 33-235 (285) alignment 
Range on Protein: 1164-1358
Range on HMM: 33-235/285.0
DYNIKKNRYPSVVPLDSSRVVLSVDGGDYINASFADAFRK-RNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQEDTLT-YPQYWPSKGSETYDHL
. |   |||  |  .. .||||     ||| ||.     | ....| || ||  |...||||| | ||  ..||  | |  .     |.| |  |     
eanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfg

NVRLMSREKQGKL----ISRKL-AIGQKVSEHEV---VHIQHIEWPDKCAPVNHQSVLDLVSWVQLSqqQCGDKAIVVQCSNGVGRSGTFCAIYSLLERI
.  .   | . .     |   |  |  . .  |     |.|   |||. || . . ...|  ||.    .  .| |.|.|| ||||. ||  |     ||
kyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkv..npkekpicvhcsagvgrtatfvgidyatiri

KAEQV
  .  
menpn
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 865-1109 2.9e-24 80.3 In-house 44-277 (312) alignment 
Range on Protein: 865-1109
Range on HMM: 44-277/312.0
KKRNRYANIIAYDHSRVRLRDnQESDYINASYLHvkpwrnaegipsVCcvQRPAPFVPCKRPLPVTVADFWQLVWQEQVTTIVMLTNIVEVGKTKCHRYW
|  ||| ||  .|  |  |   .|  || | ...            .|   .|  || .. ||  |.. ||||.     |.|..|. .|| |  || .| 
kdlnrypniqcwdrgrftlag.denfyihanfvk............ic..tkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyi

PEGKA------------RHGEFDISLHREEVFADYVVRtfIIKKDEGQSRQVVQFQYTSWPDKGVPRHATSVLgfrRKVRAhytSRNGQVPMLVHCSAGV
 .  .               | .|  .  .  .  |..  .. |  ||  .. ..|..||||.|.|    . |   | . |    .. . |.. ||||||
sdivgfvdledhrvyteycteieiggkskdkithrvlk..vvvkatgqesklnhyqwaswpdhgmpdscdtal...rllsa...vkkdkkpviahcsagv

GRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEALT
||||... |..|.   .. .  ....   ..|..|.  ...  || ..  .||| | 
grtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefly
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1166-1360 5.5e-24 79.5 In-house 48-253 (305) alignment 
Range on Protein: 1166-1360
Range on HMM: 48-253/305.0
NIKKNRYPSVVPLDSSRVVLSVD-GGDYINASFADAFRKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQEDTL-TYPQYWPSKGSETYD----
. .||||  |  ||  || |      .|| | .  .  . . || ||||||.| |.||.|  | |. .| || ||.|       .|..||  .. .    
eagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeek

--HLNVRLMSR-------EKQGKLISRKLAI-GQKVSEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQqqcgdKAIVVQCSNGVGRSGTFCAIYSL
  .. |.. |        . . |.   .| | |   . . | |   |.|||.  |   ...|.|.   . |.       ||| || |.||.|.   .  .
gqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpsk.....gpivvhcsagigrtgsvvmleyi

LERIKAEQVVD
|... | |...
ldqllagqiie
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 913-1116 5.6e-24 79.6 In-house 21-228 (255) alignment 
Range on Protein: 913-1116
Range on HMM: 21-228/255.0
CVQRPAPFVPC-KRPL-PVTVADFWQLVWQEQVTTIVMLTNIVEVGKTKCHRYWPEGKARHGEF-DISLHREEVFADYVVRTFIIKKDEG---QSRQVVQ
| .  .|  .  .. |  .||. |.| . | . ...|||..  | |. ||..|.|  |  .  . |...   .  || |.||  |    |   . ..|  
ctehvkPekdkkrknlysltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkh

FQYTSWPDKGVPRHATSVLGFRRKVRahyTSRngqvPMLVHCSAGVGRTGAFIAIDAMLE----RAKKEKTVDIH--NYVNVMRNNRCTMIQTEDQYAFV
..|. |..|  |. |  .|   . ||    |.    ...||||.|.||. ||. .. .        .. .||..   . .. .|..| . |.|  | || 
ysykGWieknaPelareilnilkvvr...dsk....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafs

HFAVLEALtCGNTEIE
 . ||. .   ..|.|
ilmvldlv.fpkgele
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 920-1101 1.1e-23 78.5 In-house 6-196 (198) alignment 
Range on Protein: 920-1101
Range on HMM: 6-196/198.0
FVPCKRPLPVTVADFWQLVWQEQVTTIVMLTNIVEVGKTKCHRYWPEGK---ARHGEFDISLHREEVFADYVVRTFIIKKDE---GQSRQVVQFQYTSWP
.. ...||  |.|||||.||.     |||. .     ..    |||  .   ...| . .. .   . .||.. ..|. ..      .|.. ..|.||| 
yiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswk

DKGVPRHATSVlGF---RRKVRAHYTsRNGQVPMLVHCSAGVGRTGAFIAIDAMLERAKKEKT--VDIHNYVNVMRNNRCTMIQTEDQYAFVH
.|  |  |  | ||    |.|  .|  .. . |..|||| | | || |.|.|  .   .. ||  ||. .  . .|. || .| . ..| |..
ekttpnvalfv.gfvvasrevskkye.qekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 920-1101 1.2e-23 78.3 In-house 7-197 (199) alignment 
Range on Protein: 920-1101
Range on HMM: 7-197/199.0
FVPCKRPLPVTVADFWQLVWQEQVTTIVMLTNIVEVGKTKCHRYWPEGK---ARHGEFDISLHREEVFADYVVRTFIIKKDE---GQSRQVVQFQYTSWP
.. ...||  |.|||||.||.     |||. .     ..    |||  .   ...| . .. .   . .||.. ..|. ..      .|.. ..|.||| 
yiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswk

DKGVPRHATSVlGF---RRKVRAHYTsRNGQVPMLVHCSAGVGRTGAFIAIDAMLERAKKEKT--VDIHNYVNVMRNNRCTMIQTEDQYAFVH
.|  |  |  | ||    |.|  .|  .. . |..|||| | | || |.|.|  .   .. ||  ||. .  . .|. || .| . ..| |..
ekttpnvalfv.gfvvasrevskkye.qekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
0051082 (Phosphotyrosine protein) phosphatases II 1191-1362 1.2e-23 78.9 In-house 4-128 (151) alignment 
Range on Protein: 1191-1362
Range on HMM: 4-128/151.0
DYINASFADAFrkrnaFILTQAPlehtMAEFWHMICQYKIGTIVMLNNLQEDTlTYPQYWPSKGsetydhlnvrlmsrekqgklisrklaigqkvseHEV
||||.|. . .     ......|    .|.|. .. ...| |||.|....|   ..|.|.|. |                                 .||
dyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg.ycpeylpelg.................................iev

VHIQHIEWPDKCAPVNHQSVLDLVSWVQLsqqqCGDKAIVVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVF
.||. . |||   |.. ..||.......     .... ..| || |.||.||..|.| .|... .|.... .
lhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllgvsleealeey
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1165-1360 3.4e-23 76.7 In-house 51-257 (310) alignment 
Range on Protein: 1165-1360
Range on HMM: 51-257/310.0
YNIKKNRYPSVVPLDSSRVVLSVDG---GDYINASFADAFRKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQEDTLTY-PQYWPSKG-SETYD
 ...||||  || ||.||| | .|    .||| | .  .   |..|| .| ||.||. .|| || | .  .|..| .  |.       |||| | .||| 
kymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetyg

HLNVRLMSREKQGKLI--------SRKLAIGQKVSEHE---VVHIQHIEWPDKCAPVNHqsvLDLVSWVQLSQQQCGdkAIVVQCSNGVGRSGTFCAIYS
 . |  .|   .   |          .. . .. .. .   |  |.  .|||.  | ..      |    |.| . |    ||.|| |..| .. .|.  
cirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdek...chtvpqrllaqvrhg..pcvvhcsagkdrlyvvvalkl

LLERIKAEQVVD
 .....  . ||
kidkldrglkvd
0048076 (Phosphotyrosine protein) phosphatases II 994-1104 4.3e-23 77.0 In-house 37-139 (145) alignment 
Range on Protein: 994-1104
Range on HMM: 37-139/145.0
IKKDEGQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAHYTSrnGqVPMLVHCSAGVGRTGAFIAIDAMLErakkeKTVDIHNYVNVMRNNRCTMIQT
    |. .|...|..|..||| |||  .  .| | . ..... .  |  |.||||||||||||...|.. ||.     . |.... .. .|. |  ....
tselellerlgiqylylpwpDhgvpdllellleflefieealke..g.gpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpn

EDQYAFVHFAV
..|. |.. ..
pgqlrflyefe
subfamily_ptpA1_pd Subfamily ptpA1 1156-1352 1.4e-22 75.0 In-house 37-255 (418) alignment 
Range on Protein: 1156-1352
Range on HMM: 37-255/418.0
ENSKVGRADYNIKKNRYPSVVPLDSSRVVLS----VDGGDYINASFADAFRKRnAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQEDT-LTYPQYW
 ..  |   .|  ||||  ..|.. .|| |      .| ||||| . |    .  || || ||  |.|.||.|. . .   ||||.   |.  .   .||
setsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk.qfictqgplpntiadfwrmvwenrcriivmlsresencrikcdryw

PS-----------KGSETYDHLNVRLMS--REKQGKLISRKLAIGQKVSEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQC---GDK--AIVVQ
|            .| | .   .| |.   .. . ..|.|.. .  .   ... . |.  |||.  |   | . .|.  .   |.|     |.   |.|.
peqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivh

CSNGVGRSGTFCAIYSLLER
|| ||||.||||.   ....
csagvgrtgtfctavimmkk
0048179 (Phosphotyrosine protein) phosphatases II 991-1101 3.5e-22 74.1 In-house 48-138 (144) alignment 
Range on Protein: 991-1101
Range on HMM: 48-138/144.0
TfiikkdegqsrqVVQFQYTSWPDKGVPRHATSVLGFRRKVRAHYTsrNGqVPMLVHCSAGVGRTGAFIAIDAMLerakkEKTVDIHNYVNVMRNNRCTM
.            ..|.....||| ||| ... .| | . .....   .|  |.||||||||||||...|.. |.     .. ..... .. .|. |. .
e............giqylhlpwpDhgvpdllellleflefieeale..eg.gpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpga

IQTEDQYAFVH
.....|. |..
vpnpgqlrfLl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 865-981 4.7e-22 73.2 In-house 48-167 (350) alignment 
Range on Protein: 865-981
Range on HMM: 48-167/350.0
KKRNRYANIIAYDHSRVRLR-----------DNQESDYINASYLHVKPWrNAEGIPSVccvqrpaPFVPCKRPLPVTVADFWQLVWQEQVTTIVMLTNIV
  .||| ||. |.||||.|.             . .|||||.||...   . |  |.         ..  . ||| || ||.... . .|. |..||. |
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrf.sveinpdf.......kYiatqaPlpstvddfykvillnkvkvilsltsdv

EVGKTKCHRYWPEGKARHGEFDISLHRE
| .  ||.|||.||.       .. ..|
elnlekcyrYWqegsydditvklaskwe
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1165-1356 4.8e-22 72.9 In-house 36-230 (281) alignment 
Range on Protein: 1165-1356
Range on HMM: 36-230/281.0
YNIKKNRYPSVVPLDSSRVVLSV-----DGGDYINASFADAFRKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQEDTL-TYPQYWPSKG--SE
 | |||||  .  || ||| | |     .  ||| | .  .   .  .|||| | . | |.||.|| | .  .|||| .. |       .|.| .     
vnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahccl

TYDHLNVRLMSREKQGKLISRKLAIGQKVSEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQlsqqqCGDKAIVVQCSNGVGRSGTFCAIYSLLERIKAE
 .|.| |       .  |.. .| .  .   . . |    ||||   |   . .| ..  ..     .     |..|| |||||||. |.   |. |.. 
qfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkir.....arstppvihcsagvgrsgtlmaveialqsihsh
subfamily_CG42327_pd Subfamily CG42327 864-1033 1.2e-20 68.5 In-house 28-192 (319) alignment 
Range on Protein: 864-1033
Range on HMM: 28-192/319.0
NKKRNRYANIIAYDHSRVRL---RDNQESDYINASYLhvKPWRNAegipsvccvqrPAPFVPCKRPLPVTVADFWQLVWQEQVTTIVMLTNIVEVGKTKC
 |...|..|..   ..|| |    |.... |..|||.  .  ..|           |. .. .. .|  . .|||..||. |  .|| ||.. | |  .|
skdksrvinvvPlPetrvvlqrigdddkdeyldasyv..rGydda...........pnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvc

HRYWPE-----GKARHGEFDISLHREEVFADYVVRTFIIKKDEG-QSRQVVQFQYtSWPDKGVPRHATSVLGFRRKVRA
 .|.|      ..  .|.. ..|   ||   |.. |...|. .. .||..  . |  |.. .|| . ....    .||.
aeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrs
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1044-1111 1.8e-20 67.1 In-house 1-68 (69) alignment 
Range on Protein: 1044-1111
Range on HMM: 1-68/69.0
MLVHCSAGVGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEALTCG
|.||||.| ||||.||||   . | | || ||| | |. ||  |  |.  | .| |.| |. |||  |
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1155-1358 2e-20 67.8 In-house 22-260 (297) alignment 
Range on Protein: 1155-1358
Range on HMM: 22-260/297.0
DENSKVGRADYNIKKNRYPSVVPLDSSRVVL--SVDGGDYINASFADAF--RKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQEDTLT--YPq
 |.  . . .  ..||||  ..  |..|| |  .. . ||||| .       .   .||.| ||. |. .||... .  ...|||. .||||     .| 
gesfssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcap.

YWPSKGSE--TYDHLNVRLMSREK--QGKLISRKLAIGQKVSEHEVVHIQHIEWPDKCAPVNHQS-----------------VLDLVS------WVQLSQ
||||   |  .  .. |  .|.      ..|  .| .  .  .  | |.|.. |||.  | . .                  .| ||       ..||  
ywpsvvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqles

QQ---CGDKAIVVQCSNGVGRSGTFCAIYSLLERIKAEQV
 .     .  ..| || ||||||       .|.... ...
lraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkri
PTPc_DSPc_SM00012 1290-1365 2.3e-20 68.1 In-house 2-79 (105) alignment 
Range on Protein: 1290-1365
Range on HMM: 2-79/105.0
VVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQCG-DKAIVVQCSNGVGRSGTFCAIYSLLERIKAE-QVVDVFQTV
| |... .|||...| . .|.|.|.  |. ......  | .||.||.||||.|||.|.. ||.....| . ||.||.|
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqiv
0044763 (Phosphotyrosine protein) phosphatases II 1187-1352 2.8e-20 68.2 In-house 15-137 (178) alignment 
Range on Protein: 1187-1352
Range on HMM: 15-137/178.0
VDGGDYINASFADAFrkrnaFILTQAPLehtmAEFWHMICQYKIGTIVMLNNLQEDT-LTYPQYWPSKGSetydhlnvrlmsrekqgklisrklaigqkv
. ..||||||. . .     ..|...|     |... ......|..||.|.. .|   | ...|||.. .                              
lersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag..............................

sehevVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQCGdKAIVVQCSNGVGRSGTFCAIYSLLE-R
     .. .|| .|| ..|   . .|..| ...  ....| ....| || |||||||..|.| ... .
.....iqylhipipDhgvpdllehflefvefieealdekg.gpvlVHCsaGvgRsgtlvaaylmkklg
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 873-1108 3.3e-20 66.7 In-house 46-288 (302) alignment 
Range on Protein: 873-1108
Range on HMM: 46-288/302.0
IIAYDHSRVRLRDNQESdYINASYLHVK--PWRNAEGIPSVCCVQRPAPFVPCkRPLPVTVADFWQLVWQEQVTTIVMLTNIVEVGKTKCHRYWPE---G
 | . ..  .| | ..  .|||  |...   |  | |       ..    .|  .|   |.  .| |. | .|. .| |...|| .. ||  |. .   |
ficepktmaklvdfknd.finanvlkldeikwimaqGpmdGtekkekvskkpi.vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvgg

KARHGEFDISL---HRE-EVFAD------YVVRTFIIKKDEGQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAHYTSrngqvpMLVHCSAGVGRTGA
. . |.. .     . . | |.|      | |     || . . . |  .....|||.| |..| . |   .   .. ..      .||||||||||||.
elkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdhGapkeaytaldilkfcesykkn......vlvhcsaGvGrtGt

FIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEAL
..||   ..  .|.|. |. . |  .|. |   .|.|.|  .. . |  .|
lvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkgl
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1046-1111 4.7e-20 65.7 In-house 2-67 (69) alignment 
Range on Protein: 1046-1111
Range on HMM: 2-67/69.0
VHCSAGVGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEALTCG
||||.| ||||.||||   . | | || ||| | |. ||  |  |.  |..| |.| |. |||  |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 862-1105 8.8e-20 65.3 In-house 49-282 (302) alignment 
Range on Protein: 862-1105
Range on HMM: 49-282/302.0
RDNKKRNRYANIIAYDHSRVRLRdNQESDYINASYLHVkP-WRnaegiPSVCCVQRPapfvpcKRPLPVTVADFWQLVWQEQVTTIVMLTNIVEVGKtKC
..| |.|.  .. ..|. .|.|  ... .|.||| ..| |  .     .|.  .| |      |.  .  |..||..|.||.....|.|    |. |   
kknlkknqsedvpildsnlvkle.aepdsyvnaskvev.Pelt.....rsiilaQlp......kvdsedsveeFWrmvfqekivsvvilvgeeelkk.tl

HRYWP---EGKARHGEFDISLHREEVFADYVvRTFI---IKKDEGQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVraHYTSRNGQVPMLVHCSAGVGR
. ..|   .    .|.. .   . |   . .   ..   . ..  .|  .     | |..| || . ...     ||  .  . ... ....    |.||
selfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv..fakkikadentvivSknGaGR

TGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVL
 |||..  . .|. .|.| . |.. |. .|..|...... .||.... |.|
agafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiall
subfamily_hpo-7_pd Subfamily hpo-7 929-1114 1.4e-19 65.1 In-house 45-233 (263) alignment 
Range on Protein: 929-1114
Range on HMM: 45-233/263.0
VTVADFWQLVWQEQVTTIVMLTNIVEVGKTKCHRYWPEGKARHGEF-DISLHREEVFADYVVRTFIIKKDE---GQSRQVVQFQYTSWPDKGVPRHATSV
 |.. |.| . | . ...|||..  | |. || .|.|  |     . ....   .|  | ...|  . .      . ..| ...|. |..|  |. | ..
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelarei

LGFRRKVRahyTSRngqvPMLVHCSAGVGRTGAFIAIDAMLE----RAKKEKTVDIH--NYVNVMRNNRCTMIQTEDQYAFVHFAVLEALTCGNTE
|   . .|    |.    .. ||||.|.||. ||  .. .        .. .||..   . .. .|..| . |.|  | ||  . ||. .   ...
lnilkvar...nsk....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfak
subfamily_egg_pd Subfamily egg 1131-1347 1.7e-19 64.6 In-house 4-222 (307) alignment 
Range on Protein: 1131-1347
Range on HMM: 4-222/307.0
KPTQNLSGYALEYQRLLAVSSQIEDENS-KVGRADYNIKKNRYPSVVPLDSSRVVLSVDGG----DYINASFADAFRKRNAFILTQAPLEHTMAEFWHMI
| .. || .  |..| | |. .  || | .   .| | .| | . |   ||||| | .  |    |.| |   .     | |||.||||  |. .|| |.
kkakylseivqelerrlevleesvdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmv

CQYKIGTIVMLNNLQEDtLTYPQYWPSKGSETYDH----LNVRLMSREKQGKLISR--KL-AIGQKvseHEVVHIQHIEWpDKCAPVNHQSVLDLvswvq
 | ..  ||||.  .|     . |||   |..       |..  .  ...   . |  ||  .| .   .|  ...| .. |     .  | | .     
fqeevqyivmltsrkes.erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgd...deerflehwqg.dvnnssdvysplrv.....

LSQQQCGDKAIVVQCSNGVGRSGTFCAIY
| . .   | .|||. .|| ...|. || 
lrklrnlskpvvvqdilGvskaatlvaie
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 878-1108 3.3e-19 64.1 In-house 32-257 (290) alignment 
Range on Protein: 878-1108
Range on HMM: 32-257/290.0
HSRVRLRDNQEsdYINASYLHVKPWRNAEGIpsvCCVQRPAPFVPCKRPLPVTVADFWQLVWQEQVTTIVMLTNIVEVGKT----KCHRYWPEGKA---R
..|| |..  .   .|  |.|      ..|.   . .   .|     .    |. .|| .. ||.|. .||| .  |  .      | .| ||      .
atrvvLkgygk..rfnddyiHAnrvtcpngl...rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelk

HGEFDISLHREEVFADYVVRTFIIKKDEGQSRQVVQFQYTSWPDKGVPRHATSVLGFRRKVRAHYTsrngqvPMLVHCSAGVGRTGAFIAIDAMLERAK-
 . . ..    |   |  .|. ..| |...  .|   .. .| .  |...  ..|   .||.|. |      |..|||  |. |  |. ||.        
fkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkaskt......pvivHcvdGiSrsAalaaiilgyQkiae

KEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLeaL
... | ... ....|..| ..|... ..|||  ...  |
tsgsvkledvlkalrkqralaitsalelafvdagiv..l
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1169-1354 2.3e-17 57.7 In-house 46-237 (312) alignment 
Range on Protein: 1169-1354
Range on HMM: 46-237/312.0
KNRYPSVVPLDSSRVVLSVDGGDYINASFADAFRKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQEDTLTYPQYWPSKGSETYDHLNVRLM--
 |||| .   |  |  |. |   || | |     | . |. ||.||| | . ||..       .|..|  . ||.      . |      |  . |.   
lnrypniqcwdrgrftlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyte

-------SREKQGKLISRKLAIGQKVS--EHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQlsqqqCGDKAIVVQCSNGVGRSGTFCAIYSLLERIK
           . |.  | | .  | .  |  . | |   |||.  |   .. | |.| |.        | .. .|| ||||.||.. | |..  ..
ycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavk.....kdkkpviahcsagvgrtgtlaliesmiaalr
subfamily_egg_pd Subfamily egg 860-1105 5.3e-17 56.4 In-house 36-267 (307) alignment 
Range on Protein: 860-1105
Range on HMM: 36-267/307.0
RRRDNKKRNRYANIIAYDHSRVRLR---DNQESDYINASYLHVKPWRNAegipsvccvqrpapFVPCKRPLPVTVADFWQLVWQEQVTTIVMLTNIVEVg
   .|... |   .   | |||.|.        |.| | ... ||  |               |. .. ||  || |||..|.||.|  |||||  .|  
asdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllne..............filaqaplkntvddfwrmvfqeevqyivmltsrkes.

kTKCHRYWPEGK---ARH--GEFDISLHREEVFADYVVRTFIIKKdEGQSRQVVQFQYTSWpDKGVPRHATSVLGFRRKVrahytsRNGQVPMLVHCSAG
  .|. |||  .   ..   | . |   . .  || . |   .|   |  ..    ..  . |     .  | |   ||.      ||   |..|..  |
.erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklkl.vGgddeerflehwqg.dvnnssdvysplrvlrkl......rnlskpvvvqdilG

VGRTGAFIAIDAMLERAKKE--KTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVL
| ......||.  |    .       . . |  .| .|   ...  .| ||.  ||
vskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
subfamily_CG42327_pd Subfamily CG42327 1034-1101 1.4e-16 55.1 In-house 240-308 (319) alignment 
Range on Protein: 1034-1101
Range on HMM: 240-308/319.0
HYTSRNGQVPMLVHCSAGVGRTGAFIAIDAMLERAKKE-KTVDIHNYVNVMRNNRCTMIQTEDQYAFVH
.   |. | |. |||| ||||||  || |  ... ..  ..||| . |  .|..|.  ..| .||.|..
rsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiy
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1203-1350 2.8e-16 54.4 In-house 33-172 (255) alignment 
Range on Protein: 1203-1350
Range on HMM: 33-172/255.0
KRNAFILtqaplehTMAEFWHMICQYKIGTIVMLNNLQE-DTLTYPQYWPSKGSETYDHLNVRLMSREKQGKLISRKLAIG----QKVSEHEVVHIQHIE
..| ..|       |...|...| | |  ..||| ...| .     .|.| .  |     .| . . .   . . | | |     .|   |.| | ..  
rknlysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykG

WPDKCAPVNHQSVLDLVSWVQLSqqqcgdKAIVVQCSNGVGRSGTFCAIYSLL
|..| || . . .| ..  |. |      |..||.||.|.||| .|  . .. 
WieknaPelareilnilkvvrds......ksvvvhCstGiGrsaafvlaelvy
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1165-1359 3.8e-16 53.4 In-house 50-251 (302) alignment 
Range on Protein: 1165-1359
Range on HMM: 50-251/302.0
YNIKKNRYPSVVPLDSSRVVLSVDGGDYINASFADAFRKRNAFILTQAPLEHTM---AEFWHMICQYKIGTIVMLNNLQEDTLTYPQYWPSKgSETYDHL
 |.|||. . |  ||| .| |.    .|.|||  .    ..  ||.| |   .    .|||.|. | || ..|.|   .| . |  ...| | |..| . 
knlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkk.sgdykey

-----NVRLMSREKQGKLISRKLAIGQKVSEHEVVHIQHI-EWPDKCAPVNHQSVLDLVSWVqLSQQQCGDKAIVVQCSNGVGRSGTFCAIYSLLERIKA
     |.|  .. .. |       . . .|.  .. ....  |..|  ||.  ..   .  |   ... .|. .|.   ||.|| |.| .    .|....
gkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGRagafltlavaveklqk

EQVV
.. .
gkep
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1205-1347 5.3e-16 53.4 In-house 5-156 (199) alignment 
Range on Protein: 1205-1347
Range on HMM: 5-156/199.0
NAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQEDTL-TYPQYWPSKGSET--YDHLNVRLMSREKQGKLISRKLAI----GQKVSEHEVVHIQHIE
  .| || || .|||.|| |. .   | |||.|. | .    || |||.  | |  |  |.|   .   .       | .        |  |. | |   
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDKCAPVNHQSVLDLVSWVQLSQ--QQCGDKAIVVQCSNGVGRSGTFCAIY
| .| .|     |  .|.  ..|.  .|  |  ..|.||.| | .| | |. 
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvald
subfamily_hpo-7_pd Subfamily hpo-7 1203-1349 8.9e-16 52.6 In-house 36-177 (263) alignment 
Range on Protein: 1203-1349
Range on HMM: 36-177/263.0
KRNAFILtqapLEHTMAEFWHMICQYKIGTIVMLNNLQED-TLTYPQYWPSKGSETYDHLNVRLMSREKQGKLISRKLAIGQ----KVSEHEVVHIQHIE
..| ..|    |  |...|...| | |  ..||| . .|.      .|.| .  |     || . . . | ... . | . .    |   |.| | ..  
rknlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykg

WPDKCAPVNHQSVLDLVSWVQLSqqqcgdKAIVVQCSNGVGRSGTFCAIYSL
|..| .| . ...| ..  .. |      | .|| ||.|.|||  |  . ..
Wiekndpelareilnilkvarns......kslvvhcstGiGrsaafsvaElv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1205-1347 9.4e-16 52.6 In-house 4-155 (198) alignment 
Range on Protein: 1205-1347
Range on HMM: 4-155/198.0
NAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQEDTL-TYPQYWPSKGSET--YDHLNVRLMSREKQGKLISRKLAI----GQKVSEHEVVHIQHIE
  .| || || .|.|.|| |. .   | |||.|. | .    || |||.  | |  |  |.|   .   .       | .        |  |. | |   
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDKCAPVNHQSVLDLVSWVQLSQ--QQCGDKAIVVQCSNGVGRSGTFCAIY
| .| .|     |  .|.  ..|.  .|  |  ..|.||.| | .| | |. 
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvald
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1003-1105 2.1e-15 51.3 In-house 216-341 (350) alignment 
Range on Protein: 1003-1105
Range on HMM: 216-341/350.0
QVVQFQYTSWPDKGVPRHATSVLGFRR-------K--VRAHYTSrNGQVPMLVHCSAGVGRTGAFIAIDAMLE----------RAKK----EKTVD-IHN
 | |.|.  |.| ..  .  |.|           .   . |. . . . |.|||||||||||| ....| .|.          . .|     || | |. 
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldn.arsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisi

YVNVMRNNRCTMIQTEDQYAFVHFAVL
 || .|. |  |.|. ||. |.. |.|
ivnelrkqrismvqnldqfifiYeall
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 863-1107 2.4e-15 50.9 In-house 46-278 (303) alignment 
Range on Protein: 863-1107
Range on HMM: 46-278/303.0
DNKKRNRYANIIAYDHSRVRLRDnqeSDYINASYLHVKPWRNAegipsvccvqrpapfVPCKRPLPVTVADFWQLVWQEQVTTIVMLTNIVEVGKTKCHR
.| ..||....|  |||.|.| |   | || ||||...  ..|               .  . ||. | |||||.. ...|  ...|    |  |   . 
knmdknrfvdvicldhskvklsd...ssyihasyleldsskka...............iltqlplshtaadfwqmiieqkvkcvlllltdseydklggds

YWPEGKARH--GEFDIS---LHREEVFADYVVRTFIIKKdeGQSRQVVQ-FQYTSWPDKGVPRH-ATSVLGFRRKVRAHYTSRNGQVPMLVHCSAGVGRT
 .|. .      |  |    ..| |.   .|..   . .  |. .  ..  .| .|| . .| . .  ..    ....         | .    .|.||.
vfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsn..gdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgra

GAFIAID-AMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEA
|.|  .. | |   ... ..|. . .. .|| |   .|   |...|.  . | 
gtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaeh
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1165-1346 2.9e-15 50.7 In-house 46-231 (303) alignment 
Range on Protein: 1165-1346
Range on HMM: 46-231/303.0
YNIKKNRYPSVVPLDSSRVVLSvdGGDYINASFADAFRKRNAfILTQAPLEHTMAEFWHMICQYKIGTIVM-LNNLQEDTLTYPQYWPSKG-SETYDHLN
 |..|||.  |. || |.| ||     || ||. .   ...| |||| || || |.|| || . |.  ... | . . |.|     .| .     ...  
knmdknrfvdvicldhskvkls..dssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeers

VRLMsREKQGKLI---SRKLAIGQKVSEHEVVHIQHI-EWPDKCAPVN-HQSVLDLVSWVQLSQQQCGDKA-IVVQCSNGVGRSGTFCAI
.|.    |. .|    . |.    . . .  .|..|  .|| .  | .    ..  .  .|   ..  |    |     |.||.|||. .
irvg.efkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalf
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1180-1346 3.1e-15 51.1 In-house 32-211 (290) alignment 
Range on Protein: 1180-1346
Range on HMM: 32-211/290.0
SSRVVLSVDG----GDYINASFAdAFRKRNAFILTQAPLEHT-------MAEFWHMICQYKIGTIVMLNNLQEDTLTY-----PQYWPSKGS--ETYDHL
 .|||| . |     ||| |..   . .  ..||||.|.|..       . .|| |. | |.  .||| . .| .         .| | .     ... |
atrvvLkgygkrfnddyiHAnrv.tcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgl

NVRLMSREKQGKLISRKLAIG-QKVSEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQlsqqqCGDKAIVVQCSNGVGRSGTFCAI
.|.  |.||.  .. |.| .  ..  |. | | .  .| .  .. .....|.|.. |.     . . ...| | .|. || .. ||
tvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk.....asktpvivHcvdGiSrsAalaai
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1155-1270 4.2e-15 50.3 In-house 36-167 (350) alignment 
Range on Protein: 1155-1270
Range on HMM: 36-167/350.0
DENSKVGRADYNIKKNRYPSVVPLDSSRVVLS------------VDGGDYINASFADAF----RKRNAF--ILTQAPLEHTMAEFWHMICQYKIGTIVML
 .. ..        ||||  ..| . ||| |             . . |||||..        .    |  | |||||  |. .|...| . |.  |..|
snDvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsl

NNLQEDTLT-YPQYWPSKGsetYDHLNVRLMSREK
....|  |  . .||.  .   ||  .|.| |. .
tsdvelnlekcyrYWqegs...ydditvklaskwe
fn3 Fibronectin type III domain 235-317 6.6e-15 48.2 Pfam-A 2-85 (85) alignment 
Range on Protein: 235-317
Range on HMM: 2-85/85.0
APSLVSVVAMTSKSMQVTWKRPSLINGPLLGYKISYTRLPIME-WAEKTLPGPVTSDVIDGLAKWSSYKVQVRVYNDKGDGPLS
||. .|| ..|| |....|. |.  .||. ||.. |     .| | |.|.|.. || .. ||   ..|...|. .|..| || |
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1041-1108 7.1e-15 49.6 In-house 228-295 (297) alignment 
Range on Protein: 1041-1108
Range on HMM: 228-295/297.0
QVPMLVHCSAGVGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAFVHFAVLEAL
....||||||||||.|  .  |..|.. .|..  |.   ....|..|  ..|| .|. ... |||. |
nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_CG42327_pd Subfamily CG42327 1168-1314 1.1e-14 48.8 In-house 30-187 (319) alignment 
Range on Protein: 1168-1314
Range on HMM: 30-187/319.0
KKNRYPSVVPLDSSRVVLSVDG----GDYINASFADAFRK-RNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQEDT-LTYPQYWPSK----GSET
.|.|.  ||||  .||||   |      |..||.   ... .| .| .|..|| . ..|| .. . .  .|| | .|.|      ..|.|.|    . ..
dksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntsl

YDHLNVRLMSREKQGKLISRKLAIgQKVSE---HEVVHIQHiEWPDKCAPVNHQSVLDLV
| .. | |  || . . .   | . ..| .    |. |  . .|..   | ...... ..
yGdilvtlkgrevkdryaistlll.krvdkeesrelthywy.kwleaevPaeeaaliaml
subfamily_eak_pd Subfamily eak 1159-1306 1.9e-14 47.8 In-house 45-197 (332) alignment 
Range on Protein: 1159-1306
Range on HMM: 45-197/332.0
KVGRADYNIKKNrYPSVVPLDSSRVVLSV---DGGDYINASFADAFRKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVML-NNLQEDTLTYPQYWPSKG
....   ....|    .|| |   | |.    .   ||||| |.     . .||| .. |  .  || |. . |  .||.| ......   . .|.| |.
setarleavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdkt

S--ETYDHLNVRLMSREKQGKLISRKLAIGQKVSEHEVVHIQHIEWPDKCAPVN
     . .|.|   .  |...|  |.| . .    |.| | .   | .   |. 
reelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpky
0048076 (Phosphotyrosine protein) phosphatases II 1248-1360 3.5e-14 48.2 In-house 36-116 (145) alignment 
Range on Protein: 1248-1360
Range on HMM: 36-116/145.0
QywpskgsetydhlnvrlmsrekqgklisrklAIGQKVSEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQcgDKAIVVQCSNGVGRSGTFCAIY
                                .  ..  |......... ||| ..|  .. .|... ...  ...  .. ..| || ||||.||..|.|
l...............................tselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaay

SLLE-RIKAEQVVD
 .|. .. .|....
lmlllgvsleeale
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1164-1307 4.9e-14 46.5 In-house 94-240 (244) alignment 
Range on Protein: 1164-1307
Range on HMM: 94-240/244.0
DYNIKKNRYPSVVPLDSSRVVLSVD--GGDYINASFADAFRKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQEDTltypQYWP-SKGSETYD-
  |  |||  . .|.| .|| ||    |  ||||||   . .   .|||| ||  |  .||.|. . ..  .|.|  ..|.     .||| |.  | |. 
pnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed....eywpdseplewyee

HLNVRLMSREKQGKLISRKLAIGQKVSE-HEV-VHIQHIEWPDKC-APVNH
 . | |  |..  .. . .| |   . | |.    .|  .||    .| .|
ditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgttpndh
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 865-968 5.9e-14 46.2 In-house 49-157 (349) alignment 
Range on Protein: 865-968
Range on HMM: 49-157/349.0
KKRNRYANIIAYDHSRVRLRDN-QESDYINASYLHVKPWRNAEGIP----SVCCVQRPAPFVPCKRPLPVTVADFWQLVWQEQVTTIVMLTNIVEVGKTK
  .||| .|. |.||||.|.   . |  |.||  . .  .  . |     ..  ..    ..  . ||| || ||....  ..|  .. |..  | .  |
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslek

CHRYWPEGK
|..|| |..
cdiywqels
0048179 (Phosphotyrosine protein) phosphatases II 1259-1360 1.7e-13 46.0 In-house 48-118 (144) alignment 
Range on Protein: 1259-1360
Range on HMM: 48-118/144.0
DhlnvrlmsrekqgklisrklaigqkvseheVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQqcGDKAIVVQCSNGVGRSGTFCAIYSL-LERIKAEQ
                               .....|. ||| ..|   . .|... ...  ..   .. ..| || ||||.||..|.| . .... .|.
e..............................giqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmkklglslee

VVD
...
ala
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1200-1290 2.1e-13 44.4 In-house 231-320 (440) alignment 
Range on Protein: 1200-1290
Range on HMM: 231-320/440.0
AFRKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQEDTLTypQYWPSK-GSETYDHLNVRLMSREKQGKLISRKLAIGQKVSEHEV
 . |.|||| || ||. |. .|| .. .|.| ||.|||.|.. | .   ||| .  | |.  . |     |.  ..  | | .  |   ||.
gyskknafiatqmpldstvldfwrlvhdyristiimlnqlndktcs..iywpvntrsvtfgpftvghkgsenmnrvkvrtlelkykeevhei
fn3 Fibronectin type III domain 139-220 4.5e-13 42.3 Pfam-A 3-85 (85) alignment 
Range on Protein: 139-220
Range on HMM: 3-85/85.0
PAEPVASKLTTSSATITWNQPPlgQGQGIVTSYELHYGNA-SF--SQSETLQGSSRSHVISGLQVYSNYSAKIRAISRVGIGAWS
|  . .|  |..|.|..|. |.  .|.| .|.||..| .. .   ... |. ....|....||. ...|. ...|....| | .|
PenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1180-1302 1.3e-11 38.9 In-house 7-125 (130) alignment 
Range on Protein: 1180-1302
Range on HMM: 7-125/130.0
SSRVVlsvdGGDYINASFADAFRKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQEDTltypQYWPSK-GSETY-DHLNVRLMSREKQGKLISR
 ||.     | .||||||     . . ..|||.||  |  .||.|. .  .  .|.|  ..|.     .|||     | | ... | |  |..  .. . 
vsrlq....gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed....eywpdsePlewyeediivtltdrdefknikas

KLAIGQKVSE-HEVVH-IQHIEWPDKC
.| | ... | |. .  .|  .||   
nleiesdlneshqaltmfqisnwpsdg
fn3 Fibronectin type III domain 332-414 1.4e-11 37.5 Pfam-A 2-83 (85) alignment 
Range on Protein: 332-414
Range on HMM: 2-83/85.0
PPGSVKVIATSSKSVRISWSLPPldSIHGIVRSFLIVYNRTDRSA-HYSQRITGNSTlFASFDSLAIYTEYSFQVLAVTVA-DGP
.|. ..|....| |...||| |.  . .| . .. . |  .. .  . ........|  . .  |  .|||.|.| ||. |  ||
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavngagegp
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1002-1105 9.5e-11 35.6 In-house 218-341 (349) alignment 
Range on Protein: 1002-1105
Range on HMM: 218-341/349.0
RQVVQFQYTSWPDKGVPRHATSVLG---FRRK------VRAHYTSrNGQVPMLVHCSAGVGRTGAFIAIDAMLE---RAKK--------EKTVD-IHNYV
 ...|.|.  |.| ..     |.|     . .       | .. . .   ..||||||| |||| .. .| .|.     ..         .. | |.  |
yellqlqvknwldlslllnPisilqalevkndliddlfarlyldt.dqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiiv

NVMRNNRCTMIQTEDQYAFVHFAVL
| .|  |  |.|   |. ... |.|
nelrkqrismvqnlaqfiaiyealL
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1166-1241 2.3e-10 34.5 In-house 34-112 (332) alignment 
Range on Protein: 1166-1241
Range on HMM: 34-112/332.0
NIKKNRYPSVVPLDSSRVVLSVDGG--DYINASFADAFRKRNAFILTQAPL-EHTMAEFWHMICQYKIGTIVMLNNLQE
|.  || | .  .| ||| |. . |  |. |||. | . |..|.|..|||. .||   ||.|. . |   |... ...|
nmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdide
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1212-1362 1.1e-09 32.2 In-house 98-257 (302) alignment 
Range on Protein: 1212-1362
Range on HMM: 98-257/302.0
APLEHTMAEFWHMICQYKIGTIVMLNNLQEDT-LTYPQYWPSKGS--ETYDHLNVRLMSREKQGKLISRK---------LAIGQKV-SEHEVVHI-QHIE
 |   |.  .| .| ||... .| | .. ||    . .|.  |     .. .  |. .| ... .  . |         .   .|    .  |.| ..  
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPDKCAPVNHQSVLDLVSWVQLSQqqcgdKAIVVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVF
|||. || . .. ||.. . .  .     |...| ||.||||.||. ||   ..  . ..| |. 
wpdhGapkeaytaldilkfcesyk.....knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdll
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1158-1211 1.5e-09 31.9 In-house 40-94 (95) alignment 
Range on Protein: 1158-1211
Range on HMM: 40-94/95.0
SKVGRADYNIKKNRYPSVVPLDSSRVVLSVD-GGDYINASFADAFRKRNAFILTQ
  || .. || |||.  ..| |..||||.     ||||| | | . ..|..| .|
ytvgsseanipknrflnifpydatrvvlttkrdsdyinacfvdgyarkncyiaaq
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1329-1365 2.8e-09 31.3 In-house 1-37 (69) alignment 
Range on Protein: 1329-1365
Range on HMM: 1-37/69.0
IVVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTV
.||.|| | ||.||| ||   . |||.|..||.|  |
mvvhcssgtgrtgtfiaimvemarikseklvdifnnv
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1294-1363 3.5e-09 30.5 In-house 95-164 (440) alignment 
Range on Protein: 1294-1363
Range on HMM: 95-164/440.0
QHIEWPDKCAPVNHQSVLDLVSWVQLSQQQCGDKAIVVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQ
..  ||||  |     || ..  |. ||...|.  ..|.|| |.||.|   |. |.|   |  . .|.| 
hyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifs
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 845-898 3.7e-09 30.4 In-house 28-84 (440) alignment 
Range on Protein: 845-898
Range on HMM: 28-84/440.0
FQTLPSGQQFTWEVARRRDNKKRNRYANIIAYDHSRVRLRDN---QESDYINASYLH
.  |||| .   ..|   .|| .||| ||.||||||| | .     .||||||||. 
wsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyin
fn3 Fibronectin type III domain 611-696 5.3e-09 29.3 Pfam-A 2-85 (85) alignment 
Range on Protein: 611-696
Range on HMM: 2-85/85.0
APRSLKLISADKREVCLKWVMPT--DEKVEKYYISYSGLKTYDpsfsvsKRAEFNGP--SVSGCVQGLTPGTVYGLTVSAKTACGHGPES
||. |....   ... |.|  |.  ......| . |.   . .      .  ||. |  . |  ..||.||| | ..| | .. | ||||
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge......ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1330-1365 7.1e-09 29.9 In-house 1-36 (69) alignment 
Range on Protein: 1330-1365
Range on HMM: 1-36/69.0
VVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTV
||.|| | ||.||| ||   . |||.|..||.|  |
vvhcssGtGrtGtfiaimvemarikseklvdifnnv
0038934 (Phosphotyrosine protein) phosphatases II 1288-1357 5.2e-08 28.2 In-house 77-147 (194) alignment 
Range on Protein: 1288-1357
Range on HMM: 77-147/194.0
HEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQCGDKAIVVQCSNGVGRSGTFCAIYSLL-ERIKAEQ
   ... .. .||.... . . .|. ...|.   ... .....| |  |.||.||..| | .   ...||.
kagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaee
subfamily_eak_pd Subfamily eak 854-1021 7.9e-08 26.0 In-house 42-198 (332) alignment 
Range on Protein: 854-1021
Range on HMM: 42-198/332.0
FTWEVARRRDNKKRNrYANIIAYDHSRVRLRDNQE--SDYINASYLHVkpwrnaegiPSVCcvqRPapFVPCKRPLPVTVADFWQLVWQEQVTTIVMLTN
 . ....| .. .||   .|. ||.  |||   |     ||||| .           . |    |   ..    .    |  |||.| ...  .||.| .
lsisetarleavnrn.vvkivpydrylvrltssqlnrlGyinaslaef.........sevG...rk..yiltGiasedkvfafwqmvleqkspaivqlle

IVEVGKTKCHRYWPEGK---ARHGEFDISLHREEVFADYVVRTFIIKKDEgQSRQVVQFQYTSWPDKGVPRHA
 || .  |  .|.|.      ..| .|.        . . .| ....| . .. .|  ...  | .  .|.  
dvelkleksdkyfpdktreelkfGildverkefvkrniletrllelskGn.ethrvlhykvfGwtettlpkye
subfamily_PTPDC1_pd Subfamily PTPDC1 1001-1101 9.8e-08 26.6 In-house 79-169 (182) alignment 
Range on Protein: 1001-1101
Range on HMM: 79-169/182.0
SRQVVQFQYTSWPDKGVPRhATSVLGFRrKVRAHyTSRNGQVpmLVHCSAGVGRTGAFIAIDAMLErakkeKTVDIHNYVNVMRNNRCTMIQTEDQYAFV
 .| . .   .|.| ||.   ...|    || |  . ..|.|   ||| || ||||  ||   .       | .. .. ....|..|   ||| .|  .|
meqgiyvynfgwkDygvas.leriLdiv.kvvaf.alqegkv..avhChaGlGrtGvliacylvya.....krltaekaiklvrskrpksiqtreqvelv

H
.
k
fn3 Fibronectin type III domain 530-599 1.1e-07 25.0 Pfam-A 25-85 (85) alignment 
Range on Protein: 530-599
Range on HMM: 25-85/85.0
CSNGPITSYKVRLTLVKQGRqvrtvrgisSEIVRVVPGSQTSVIVSGLHACAEYSISVRGNTSAGGGPFS
  .||||.|.|..  . .|.          .  . ||...|||...|| . .||...|.  . ||.||.|
dgggpitgYeveyrekggge.........ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1174-1265 1.3e-07 25.3 In-house 74-165 (349) alignment 
Range on Protein: 1174-1265
Range on HMM: 74-165/349.0
SVVPLDSSRVVLSVDGGDYINASFAD--AFRKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQEDTLTY-PQYWPSKgseTYDHLNVRL
| |   |     |    ||||| .     .   . .| |||||  |. .|...|   ..  .. ||. .| .|    .||      .|.  .|.|
skvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqel...sysnitvkl
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1165-1242 1.8e-07 25.0 In-house 36-122 (347) alignment 
Range on Protein: 1165-1242
Range on HMM: 36-122/347.0
YNIKKNRYPSVVPLDSSRVVLSV---------DGGDYINASFADAFRKRNAFILTQAPLEHTMAEFWHMICQYKIGTIVMLNNLQED
 ...|||   |   |..|||||          |   |||||       .. .|||| || .|. .||.|.   |.  .| . . ..|
kslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikd
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1287-1353 1.9e-07 25.2 In-house 214-289 (350) alignment 
Range on Protein: 1287-1353
Range on HMM: 214-289/350.0
EHEVVHIQHIEWPDKCAPVNHQSVLDLVS---------WVQLSQQQCGDKAIVVQCSNGVGRSGTFCAIYSLLERI
 ..| ..|   |.|    .| .|.|  .            ..  ..   ..|.| || |||| ||.... |||. .
PyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdf
fn3 Fibronectin type III domain 441-508 5e-07 23.0 Pfam-A 11-78 (85) alignment 
Range on Protein: 441-508
Range on HMM: 11-78/85.0
PtcpTPPRVTLQWDPPAeINDARIKYYTVTHRNAEQPA-AKTVNVTMTSYPITVMG---GVRYAFSVVAVTV
    |.  .||.|.||.  ... |..|.|. |.....   |...|. |..  |. |   | .| |.| ||. 
v...tstsltlsWsppk.dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavng
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 855-898 5.7e-07 23.6 In-house 39-82 (95) alignment 
Range on Protein: 855-898
Range on HMM: 39-82/95.0
TWEVARRRDNKKRNRYANIIAYDHSRVRLRDNQESDYINASYLH
.. |     |  .||. ||. || .|| |  ...|||||| .. 
pytvgsseanipknrflnifpydatrvvlttkrdsdyinacfvd
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 919-996 7e-07 22.9 In-house 237-313 (440) alignment 
Range on Protein: 919-996
Range on HMM: 237-313/440.0
PFVPCKRPLPVTVADFWQLVWQEQVTTIVMLTNIVEvgKTkCHRYWPEGK--ARHGEFDISLHREEVFADYVVRTFIIKK
 |.  . ||  || |||.|| . ...||.|| .. .  || |  |||        | | .  .  | .    |||. .| 
afiatqmpldstvldfwrlvhdyristiimlnqlnd..kt.csiywpvntrsvtfgpftvghkgsenmnrvkvrtlelky
I-set Immunoglobulin I-set domain 23-72 1.7e-06 19.8 Pfam-A 8-55 (90) alignment 
Range on Protein: 23-72
Range on HMM: 8-55/90.0
LNLTATPGQSRDLICKVTGQPVPrQITWFANESDVNHlSSGVTQQGNTLT
 ..... |.| .| |.|.|.| | ...|. ..|...  |. |. . .  .
kdvevseGesvelectveGepep.svsWakdgselks.sqrvkvtveeae
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 954-1099 2.1e-06 21.4 In-house 144-293 (332) alignment 
Range on Protein: 954-1099
Range on HMM: 144-293/332.0
EVGKTKCHRYWPEGKARHGEFDISLHREEVFADYVVRTFIIKK-DEGQSRQVVQFQYTSWPDKGvpRHATSVLGFRRKVRAHYT--SRNGQ---VPMLVH
|.    |...||| ....    .|..  . ...  ..|| .   .. | .| | ...  | |    .    .| .|  .. .|   |..      |... 
elkakicrkfwpekrskkdfpalsiqasddhsethmktfnltvtekkqdhqtvlmhfyewadas..klpeymldmrasiklqyirsskktgvcigpimlv

CSAGVGRTGAFIAIDAMLERAKKEKTVDIHNYVNVMRNNRCTMIQTEDQYAF
|..|| .   . .|| .. |  .|. | ... .. .. .|   ..|   |. 
catgvekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpyst
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 911-1017 2.3e-06 21.4 In-house 130-235 (244) alignment 
Range on Protein: 911-1017
Range on HMM: 130-235/244.0
VCCVQRPAPFVPCKRPLPVTVADFWQLVWQEQVTTIVMLTNIVEVgktkcHRYWPEGKAR-HGEFDI--SLHREEVFADYVVRTFIIKKDEGQSRQVV-Q
| |. | | ..  . ||  |  |||... .  |  .|.|  . |        |||. .     | ||  .|   . | .     . |. |  .| | .  
vgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltm

FQYTSWPDKGV
|| . ||  | 
fqisnwpsdgt
0038934 (Phosphotyrosine protein) phosphatases II 1008-1085 3.3e-06 22.4 In-house 83-157 (194) alignment 
Range on Protein: 1008-1085
Range on HMM: 83-157/194.0
QYTSWPDKGVPRHATSVLGFRRKVRAHYTSRNGQVpMLVHCSAGVGRTGAFIAIDAMLERAKkeKTVDIHNYVNVMRN
    .||.|..     .| | . |  ..   .|.|  .||| ||.|||| ..|   .  .    .  .  .... .|.
lklpfpddgtvPsleillrfldlvdeflnedpggv.vaVHCkaGlgRtGtlvaaYLiyrlgm..saeeAialfrekRp
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1284-1352 4.2e-06 20.3 In-house 213-291 (349) alignment 
Range on Protein: 1284-1352
Range on HMM: 213-291/349.0
KVSE-HEVVHIQHIEWPDKCAPVNHQSVLDLVS---------WVQLSQQQCGDKAIVVQCSNGVGRSGTFCAIYSLLER
.|.. .|.. .|  .|.|    .| .|.|  .          . .|  ..    ...| || | ||.|... . .||. 
avekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsi