Gene NvecPTP-sf2-10 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily NvecPTP-sf2
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP053_AA protein Get Run
NvecP053_AA_74-340 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 64-346 2e-127 419.6 In-house 1-297 (298) alignment 
Range on Protein: 64-346
Range on HMM: 1-297/298.0
GNTEIEAGNLQIAMRKRAAVKPTQNLSGYALEYQRLLAVSSQIEDENSKVGRADYNIKKNRYPSVIPFD-------------GGDYINASFADAFRKRNA
||||||| .|..|..|.||||....|.|||||.||| .|||.||.|...|.|...| |||||...|..|              .|||||||..|...|||
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

FILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQE-DTLTYPQYWPSEGSETYDHLNVRLMSREKQGKLISRKLAIGQKGVEGEHEVVHIQHIEWPDKCA
||.||||| .|...||.|.....|||||||.||.| |...|..|||.||.|||....|.|.|.|....||.|||.. .| .|.|.||.......||||..
fiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgv

PVNHQSVLDLVSWVQLSQQQCGDKAIAVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTVKVLRLGRPGAVETLTQYIYCYQMVQRYLDSFSDYA
| |..|||||...|. ||||.|.|.. ||||.||||||||.||.|.|||.|.||||||||.|||||  |||||.| .||...|..|...||||.|..
penatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 134-347 2.1e-89 294.0 In-house 37-250 (250) alignment 
Range on Protein: 134-347
Range on HMM: 37-250/250.0
GDYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQEDTLTYPQYWPSEGSETYDHLNVRLMSREKQGKLISRKLAIGQKGVEGE
 |||||||......|.||| ||.|| .|. .|| |. ..|.||||||.||.|   ||.|||| |..|.| .. | |.|.|. . ...||| . ..  ..|
sdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvekaekyGdvtvsllskeefadytkrklklskakkade

HEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQCGDKAIAVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTVKVLRLGRPGAVETLTQYIYCYQ
  |...... ||||. | . ..||.|.. || ||||.|.. . ||||.||||||.|.||...|||.| |.|||||. .||||  ||.|||.|.||...|.
rivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvye

MVQRYLDSFSDYAN
.....|||..|||.
iilkaldsvedyar
0050432 (Phosphotyrosine protein) phosphatases II 50-346 4.4e-79 261.3 In-house 1-306 (308) alignment 
Range on Protein: 50-346
Range on HMM: 1-306/308.0
YAFVHFAVLEALTCGNTEIEAGNLQIAMRKRAA-VKPTQNLSGYALEYQRLLAVSSqieDENSKVGRADYNIKKNRYPSVIPFD--------GGDYINAS
| ... |.||.|....|.| . .|.. . . .  ...  .|...  |...||.|     ... .|..   |..||||....|.|        | ||||||
yllildallelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkp...lleysvallpenkdkNrykdilpydhsRVkldegsdYInAs

FADAF--RKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQEDT-LTYPQYWPSE---GSETYDHLNVRLMSREKQGKLISRKLAIGQKGVEGEH
. | .  .....||.||.|| .|.. ||.|. .... .||||..|.|.   ...||||.|   ||..|... |.|.| |...  . |.| .  .| . ..
yvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesr

EVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQqqcGDKAIAVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTVKVLRLGRPGAVETLTQYIYCYQM
.| |.... ||| ..| . ...||.. .|. |.   ... |.| ||.||||.|||.|.. |||....|. ||||..|| ||  |||.|.|. ||...|..
tvthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyra

VQRYLDSFSDYA
.. || ..  ..
lleylklkltkl
subfamily_PTPRD_pd Subfamily PTPRD 133-346 7.6e-77 254.2 In-house 75-288 (564) alignment 
Range on Protein: 133-346
Range on HMM: 75-288/564.0
GGDYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQEDTL-TYPQYWPSEGSETYDHLNVRLMSREKQGKLISRKLAIGQKGVE
| ||||||| |..|||.|.| ||.|| .|...|| |. .... |||||..|.| .   . .|||..|.|||..| | |.. |.  . . |.. . .|  .
gsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkss

GEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQqQCGDKAIAVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTVKVLRLGRPGAVETLTQYIYC
  .|| . ....|||...| . .|.|||.. |. .. ... . | |.||.||||.|||..| ..|||||.|..||..|.|| ||  |.  |.| .|||..
esreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFi

YQMVQRYLDSFSDYA
..... .|.....  
heailealacgntev
0051299 (Phosphotyrosine protein) phosphatases II 71-339 3.7e-76 251.6 In-house 8-286 (288) alignment 
Range on Protein: 71-339
Range on HMM: 8-286/288.0
GNLQIAMRKRAavkpTQNLSGYALEYQRLLAVSSQiedENSKVGRADYNIKKNRYPSVIPFD-------------GGDYINASFADAFRKRNAFILTQAP
 .|  ...|.       .|.|.. |...||..  .    . ....   |..||||....|.|             |.||||||. | ... ..||.||.|
eellklvlkll....angltglleefeellsllpd...ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgP

LGHTMAEFWHMICQYKIGTIVMLNNLQEDT-LTYPQYWPSEGSETYDHLNVRLMSREKQGKLISRKLAIGQK----GVEGEHEVVHIQHIEWPDKCAPVN
| .|...||.|. .... .||||..|.|.   ...||||..||.||... |.|.| |.... . |.| .  .    | . ...| |.... ||| ..| .
lpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpds

HQSVLDLVSWVQLSQQqCGDKAIAVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTVKVLRLGRPGAVETLTQYIYCYQMVQRYL
 ...||.. .|. ...  |.. ..| ||.||||.|||.|.. |||....|..|||...|| ||  |||.|.|. ||...|...  ||
pellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0046845 (Phosphotyrosine protein) phosphatases II 94-346 2.5e-73 242.2 In-house 4-281 (284) alignment 
Range on Protein: 94-346
Range on HMM: 4-281/284.0
LEYQRLLAVSSQIEdENSKVGRADYNIKKNRYPSVIPF--------------DGGDYINASFADAF-----RKRNAFILTQAPLGHTMAEFWHMICQYKI
 |...|| .   ..  . .|...  |..||||....|.              ...||||||. | .     .....||.||.|| .|...||.|. ....
eefeellsltvkll.lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnv

GTIVMLNNLQEDT-LTYPQYWPSEG-SETYDHLNVRLMSREKQGKLISRKLAIGQKG-VEGEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQ-C
 .||||..| |.    ..||||.|| . ||... |.|.|.|...  . |.| .  .|  . ...| |.....||| ..| . ...|... .|. ....  
rvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlp

GDKAIAVQCSNGVGRSGTFCAIYSLLERIKAEQ---VVDVFQTVKVLRLGRPGAVETLTQYIYCYQMVQRYLDSFSDYA
|.. |.| ||.||||.|||.|.. |||....|.   .|||...|| ||  |||.|.|| ||...|.... || ..  ..
gggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltll
0040438 (Phosphotyrosine protein) phosphatases II 105-339 1.6e-72 239.8 In-house 30-276 (317) alignment 
Range on Protein: 105-339
Range on HMM: 30-276/317.0
QIEDeNSKVGRADYNIKKNRYPSVIPFD-------------GGDYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQEDT-LTY
.. | . .|..   |..|||||...|.|             . ||||||. | ......||.||.|| .|.. ||.|. ......||||..| |.   ..
lkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekc

PQYWPSEGSETYDHLNVRLMSREKQGKLISRKLAIGQKGVEGEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQqCGDKAIAVQCSNGVGRSGTFC
 ||||.... ||... |.|.| |. .  . |.| .  .| . ...| |.... ||| ..| .....||....|. ...  ... ..| ||.||||.|||.
aqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfi

AIYSLLERIKAEQVVDVFQTVKVLRLGRPGAVETLTQYIYCYQMVQRYL
|.| .||... |. |||...|| ||  |||||.|. ||...|.... ||
aaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
0047943 (Phosphotyrosine protein) phosphatases II 85-339 1.1e-71 236.8 In-house 7-272 (273) alignment 
Range on Protein: 85-339
Range on HMM: 7-272/273.0
PTQNLSGYALEYQRLLAVSSqieDENSKVGRADYNIKKNRYPSVIPFD---------GGDYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYKIG
.  .|.....|...|| .     . . .|..   |..||||....|.|         | ||||||. | ... ..||.||.|| .|...||.|. .... 
kllgltllleefelllslkp...lltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvr

TIVMLNNLQED-TLTYPQYWPSEG---SETYDHLNVRLMSREKQGKLISRKLAIGQKGVEGEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQC-
.||||..|.|.   ...||||.||   |.||... |.|.| |. .  . |.| .  .| . ...| |... .||| ..| . .|.|... .|.  .... 
viVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealp

GDKAIAVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTVKVLRLGRPGAVETLTQYIYCYQMVQRYL
... ..| ||.||||.|||.|.. ||.....|. |||...|| ||  |||.|.|. ||...|...  ||
sngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0039614 (Phosphotyrosine protein) phosphatases II 87-342 1.1e-71 237.0 In-house 29-292 (297) alignment 
Range on Protein: 87-342
Range on HMM: 29-292/297.0
QNLSGYALEYQRLLAVSSqieDenSKVGRADYNIKKNRYPSVIPF--------------DGGDYINASFADAFRK-RNAFILTQAPLGHTMAEFWHMICQ
 . ... ||...|| .     |   ....   |..||||....|.               . ||||||. | ...  ..||.||.|| .|.. ||.|. .
nsktllllefeellslkp...d..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvwe

YKIGTIVMLNNLQEDTLTYPQYWPSEGSeTYDHLNVRLMSREKQGKLISRKLAIGQKGVEgeHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQC-
... .||||..| |.  ...||||.||. ||... |.|.. |. .  . |.| .  .| .  ..| |.|.. ||| ..| .....|... .|.  .... 
qgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtlevtnnges..rtvthfqytgwpdhgvppslellleflelvrealaelp

GDKAIAVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTVKVLRLGRPGAVETLTQYIYCYQMVQRYLDSF
... ..| ||.||||.|||.|.| .||... |. |||...|| ||  |||||.|. ||...|.... .|  .
kggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
0036941 (Phosphotyrosine protein) phosphatases II 90-339 3.9e-71 235.1 In-house 13-277 (297) alignment 
Range on Protein: 90-339
Range on HMM: 13-277/297.0
SGYALEYQRLlavSSQIEDENSKVGRADYNIKKNRYPSVIPFDG---------GDYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVML
...  |...|    . . . . .|..   |..||||....|.|           ||||||. | ..  ..||.||.|| .|...||.|. .... .||||
alllkefeel...lpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvml

NNLQED-TLTYPQYWPSE--GSETYDHLNVRLMSREK--QGKLISRKLAIGQKGVEGEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQC-GDKA
..| |.   ...||||.|  .| ||... |.|.| |.   .  . |.| .  .| . ...| |.... ||| ..| ...|.||.. .|.  ...  ... 
telvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggp

IAVQCSNGVGRSGTFCAIYSLLERIK---AEQVVDVFQTVKVLRLGRPGAVETLTQYIYCYQMVQRYL
. | ||.||||||||.|.. .|....    |. ||....|| ||  |||||.|| ||...|.... .|
vlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
0045450 (Phosphotyrosine protein) phosphatases II 83-339 6.8e-70 231.5 In-house 20-304 (307) alignment 
Range on Protein: 83-339
Range on HMM: 20-304/307.0
VKPTQNLSGYALEYQRLLAVSSQIeDENSKVGRADYNIKKNRYPSVIPF--------------DGGDYINASFA--------DAFRKRNAFILTQAPLGH
...  .|.|.. |...|| |  ..   . ....   |..||||....|.              ...||||||.         | ... ..||.||.|| .
lllldfltgllkefekllsvtvfl.lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpe

TMAEFWHMICQYKIGTIVMLNNLQEDTL-TYPQYWPSEGSE-TYDHLNVRLMSREKQGKLISRKLAIGQK-GVEGEHEVVHIQHIEWPDKCAPVNHQSVL
|...||.|. ......||||..| |..   ..||||.||.| ||... |.|.| |...... |.| .  . | . ...| |.....||| ..| . ...|
tvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeell

DLVSWVQLSQQQC-GDKAIAVQCSNGVGRSGTFCAIYSLLERIKAEQV---VDVFQTVKVLRLGRPGAVETLTQYIYCYQMVQRYL
|..  |.  .... ... ..| || ||||.|||.|.| .|.....|..   ||....|| ||  |||||... ||...|.... .|
dfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
0043336 (Phosphotyrosine protein) phosphatases II 88-338 2.3e-68 226.0 In-house 18-276 (278) alignment 
Range on Protein: 88-338
Range on HMM: 18-276/278.0
NLSGYALEYQRLLAVSSqiedENSKVGRADYNIKKNRYPSVIPFD-------------GGDYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYKI
. ... ||...|| .      .. ....   |..||||....|.|             . ||||||. | ... ..||.||.|| .|.. ||.|. ....
lktllllefeellsfkl....dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgv

GTIVMLNNLQEDT-LTYPQYWPsEGSETYDHLNVRLMSREKQGKLISRKLAIGQKGVEGEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQqCGDK
 |||||..| |.   .. |||| .||.||... |.|.. |...  . |.| .  .|   ...|.|.... ||| ..| . ...||.. .|.  ..   ..
ttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsng

AIAVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTVKVLRLGRPGAVETLTQYIYCYQMVQRY
...| ||.||||.|||.|.| |||... |. ||....|| ||  |||||.|. ||...|.... |
pvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 93-348 3.6e-67 221.7 In-house 23-289 (318) alignment 
Range on Protein: 93-348
Range on HMM: 23-289/318.0
ALEYQRLLAVSSQIEDENSkvgRADYNIKKNRYPSVIPFD-------------GGDYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVM
  ||.||  .....   .|     . | .||||  ....|             | |||||.. | .|...|.| .|||| .|. .|| |. . .  .|||
seeyerlsrseetvtslks...lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivm

LNNLQEDT-LTYPQYWPSEGSETYDHLNVRLMSREKQGKLISRKLAIGQKGVEGEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQCGDKAIAVQ
| ...| .     .||||.||..|..| | |... . .... |.. . ....| . .|   .. .|||.  | .  |.||||  |.  ||..| ..|.| 
ltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvh

CSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTVKVLRLGRPGAVETLTQYIYCYQMVQRYLDSFSDYANF
|| |||| |.|.|. .||||||||..|||||||| ||  |.  | |  ||...|.... .| |.  ... 
CsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevda
0040439 (Phosphotyrosine protein) phosphatases II 113-339 9.1e-67 220.6 In-house 5-246 (249) alignment 
Range on Protein: 113-339
Range on HMM: 5-246/249.0
VGRADYNIKKNRYPSVIPFD-------------GGDYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQED-TLTYPQYWPSEG
|..   |..|||||...|.|             ..||||||. | ..  ..||.||.|| .|.. ||.|. ...|..||||..|.|    .. ||||..|
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplgg

SETYDHLNVRLMSREKQGKLISRKLAIGQKGVEGEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQC-GDKAIAVQCSNGVGRSGTFCAIYSLLE
| .|... |.|.| |. .... |.| .  ..   ...| |||.. |||  .| . ...||.. .|.  ....  .. ..| ||.||||.|||.|.| .||
sleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmle

RIKAEQVVDVFQTVKVLRLGRPGAVETLTQYIYCYQMVQRYL
... |. ||....|| ||  |||||... ||...|......|
qlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0042113 (Phosphotyrosine protein) phosphatases II 114-339 7e-65 214.2 In-house 4-243 (245) alignment 
Range on Protein: 114-339
Range on HMM: 4-243/245.0
GRADYNIKKNRYPSVIPFD-------------GGDYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQEDT-LTYPQYWPSEGS
..   |..||||....|.|             . ||||||. | .|  . ||.||.|| .| . ||.|. ...| |||||... |.   ...||||...|
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplges

ETYDHLNVRLMSREKQGKLISRKLAIGQKGVEGEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQCGDKAIAVQCSNGVGRSGTFCAIYSLLERI
 ||... |.|.| |. .... |.| .  .|   ..||.|.... ||| ..| .....||....|.  ....... ..| || ||||.|||.|.| .||..
ltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleql

KAEQVVDVFQTVKVLRLGRPGAVETLTQYIYCYQMVQRYL
..|. |.....|| ||  |||||.|. ||...|.... .|
ekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
DSPc_SM00195 98-339 2e-64 212.9 In-house 8-262 (263) alignment 
Range on Protein: 98-339
Range on HMM: 8-262/263.0
RLLAVSSQIedeNSKVGRADYNIKKNRYPSVIPFD-------------GGDYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQ
.|..  |.    ... .. . | .||||  ..|.|             | |||||.. .  .|....|.||.|| .|...||.|. . |. .||||.. .
kleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteee

E-DTLTYPQYWPSE--GSETYDHLNVRLMSREKQG-KLISRKLAIGQKGVEGEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQCgDKAIAVQCS
| .  .  .|||.|  |.||.....| |.. ||.  ..| |.| . ..| | ...| ..|. .|||. .| ...|||.|.. |. |...  .. | |.||
engkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCs

NGVGRSGTFCAIYSLLERIKAEQVVDVFQTVKVLRLGRPGAVETLTQYIYCYQMVQRYL
.||||.|||..| ..|.....|. ||.|..|| ||  |||.|.||.||...|... .|.
aGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 98-339 2e-64 212.9 In-house 8-262 (263) alignment 
Range on Protein: 98-339
Range on HMM: 8-262/263.0
RLLAVSSQIedeNSKVGRADYNIKKNRYPSVIPFD-------------GGDYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQ
.|..  |.    ... .. . | .||||  ..|.|             | |||||.. .  .|....|.||.|| .|...||.|. . |. .||||.. .
kleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteee

E-DTLTYPQYWPSE--GSETYDHLNVRLMSREKQG-KLISRKLAIGQKGVEGEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQCgDKAIAVQCS
| .  .  .|||.|  |.||.....| |.. ||.  ..| |.| . ..| | ...| ..|. .|||. .| ...|||.|.. |. |...  .. | |.||
engkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCs

NGVGRSGTFCAIYSLLERIKAEQVVDVFQTVKVLRLGRPGAVETLTQYIYCYQMVQRYL
.||||.|||..| ..|.....|. ||.|..|| ||  |||.|.||.||...|... .|.
aGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 110-343 2.2e-64 212.5 In-house 39-287 (319) alignment 
Range on Protein: 110-343
Range on HMM: 39-287/319.0
NSKVGRADYNIKKNRYPSVIPF-------------DGGDYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQEDT-LTYPQYWP
. .    . | |||||. ....             .| ||||||| |....|..|| ||||| .|. .|| |. .... ..|||..|.|   . . .|||
tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywp

SEGSETYDHLNVRLMSREKQGKLISRKLAIGQKGVEG-EHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQCGDKAIAVQCSNGVGRSGTFCAIYS
.|  |.| .| | | ..|.. ..| ||| . .|  |    ||.| |. ||||.  | . .|.|||.  .. |...  .. | | ||.|||| |||...  
eenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivlda

LLERIKAEQVVDVFQTVKVLRLGRPGAVETLTQYIYCYQMVQRYLDSFS
 |||.| |.|.|||.||. ||. |.  |..  ||...|. .  ......
mlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd
Y_phosphatase Protein-tyrosine phosphatase 119-336 2.1e-63 209.3 Pfam-A 1-234 (235) alignment 
Range on Protein: 119-336
Range on HMM: 1-234/235.0
NIKKNRYPSVIPFD----------G-GDYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQE-DTLTYPQYWP--SEGSETYDH
| |||||....|.|          |  |||||.. . ... ..||.||.|| .|...||.|. |.|. .||||..|.| .  ...||||  .|.|.||..
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

LNVRLM-SRE-KQGKLISRKLAIGQKGVEG-EHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQqQCGDKAIAVQCSNGVGRSGTFCAIYSLLERIKA
..|.|. . . .. . . ||| . .|. |  ..|| .... .|||...| . .|.|||.  |. |. .  .. . |.||.||||.|||.|.  |||...|
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqlea

EQVVDVFQTVKVLRLGRPGAVETLTQYIYCYQMVQ
|. |||.|.|| ||  |||.|..|.|||..|....
eeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 119-336 2.1e-63 209.3 In-house 1-234 (235) alignment 
Range on Protein: 119-336
Range on HMM: 1-234/235.0
NIKKNRYPSVIPFD----------G-GDYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQE-DTLTYPQYWP--SEGSETYDH
| |||||....|.|          |  |||||.. . ... ..||.||.|| .|...||.|. |.|. .||||..|.| .  ...||||  .|.|.||..
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

LNVRLM-SRE-KQGKLISRKLAIGQKGVEG-EHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQqQCGDKAIAVQCSNGVGRSGTFCAIYSLLERIKA
..|.|. . . .. . . ||| . .|. |  ..|| .... .|||...| . .|.|||.  |. |. .  .. . |.||.||||.|||.|.  |||...|
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqlea

EQVVDVFQTVKVLRLGRPGAVETLTQYIYCYQMVQ
|. |||.|.|| ||  |||.|..|.|||..|....
eeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 122-342 1.3e-61 203.4 In-house 62-286 (305) alignment 
Range on Protein: 122-342
Range on HMM: 62-286/305.0
KNRYPSVIPFDGGDYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQE-DTLTYPQYWPSEGSE--TYDHLNVRLMSREKQGKL
. .       |  ||||||. |........|..|.|| .|.|.||..| ..|. ||||| .|.| .     |||| . .|   .....| | |...   .
riiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdy

ISRKLAIGQ-KGVEGEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQCGDKAIAVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTVKVLRLG
| ||| | . .. . .. |.. |  .|||.  |    |.|.|.  || .|..  .... | ||.||||.|.|.|.   |||.|.|.|||||. .| ||  
ieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRsk

RPGAVETLTQYIYCYQMVQRYLDSF
|...|.|| || ....... .. ..
rmkmvqtldqYvflhdaldelitcg
0045098 (Phosphotyrosine protein) phosphatases II 111-339 2.5e-61 202.9 In-house 25-272 (278) alignment 
Range on Protein: 111-339
Range on HMM: 25-272/278.0
SKVGRADYNIKKNRYPSVIPFDGG---DYINASFADAFrkRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQED-TLTYPQYWPSEGSETYDHLN
  ..    |..||||....|.|     ||||||. | .  ...||.||.|| .|.| ||.|. ...| .||||..|.|.    ..||||..||.||... 
itpalylgnldknRykdilpydhsrVkdYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdft

VRLMSREKQGKLISRKLAIGQK----GVEGEHEVVHIQHIEWPDKCAPVNH--QSVLDLVSWVQLSQQ------------QCGDKAIAVQCSNGVGRSGT
|.|.| |  .. . |.| .           ...| |.. . ||| ..| ..  .|.|.|. ...  ..            . ... ..| || ||||.||
vtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGt

FCAIYSLLERIkaEQVVDVFQTVKVLRLGRPG-AVETLTQYIYCYQMVQRYL
..|.| .||..  |..||....|| ||  ||| ||..| ||...|......|
lvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 80-337 8.2e-60 197.3 In-house 11-277 (288) alignment 
Range on Protein: 80-337
Range on HMM: 11-277/288.0
RAAVKPTQNLSGYALEYQRLLAVSSqieDENSKVGRADYNIKKNRYPSVIPFD-------------GGDYINASFADAFRKRNAFILTQAPLGHTMAEFW
..| |  .| .|.  ||. | |. .   ......||   | |||||. ..|.|             | ||||||. |  .|....| ||.|| .|. .||
kvakksarnrtgfseeynsLaalek...tksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfW

HMICQYKIGTIVMLNNL-QEDTLTYPQYWPSEGS-ETYDHLNVRLMSREKQGKLISRKLAIGQKgvEGEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQ
... ..|. |||||..| ...  .  .|||...  . | ...| |.. ..... . ||| ...|  ..| |. . |.  |||.  | ... .|.|.. |.
elvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekk..kteleitqyqylaWpdhgvPeskapllellrqvk

LSQQQCgDKAIAVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTVKVLRLGRPGAVETLTQYIYCYQMVQR
 ..|.   . | |.||.||||.||| |.  |......|...||. ||. ||  |.  |.||.||...|...  
vanqad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
subfamily_PTPRA_pd Subfamily PTPRA 115-338 8.6e-60 197.3 In-house 54-294 (330) alignment 
Range on Protein: 115-338
Range on HMM: 54-294/330.0
RADYNIKKNRYPSVIPFD-------------GGDYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQEDT-LTYPQYWPSEGSE
  . | .|||.. ..|.|               ||||||| | ..... || .| |. .|. .|| || ..|  ||||| .|.|       ||||.||. 
skeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlv

TYDHLNVRLMSREKQGKLISRKLAIGQKGVEG---EHEVV-HIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQCGDkAIAVQCSNGVGRSGTFCAIYSLL
|| ...| .   .   ..  ||. . |.. .    .. .|  .    |||   |.. . .|.|.  |.  .|| .. .| | || ||||.|||... ..|
tyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavl

ERIKAEQVVDVFQTVKVLRLGRPGAVETLTQYIYCYQMVQRY
||.|||..||||..|| ||| ||  | |. || ..|.... |
ervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_PTPRK_pd Subfamily PTPRK 91-335 2.4e-59 195.7 In-house 23-273 (314) alignment 
Range on Protein: 91-335
Range on HMM: 23-273/314.0
GYALEYQRLLA-VSSQIEDENSKVGRADYNIKKNR-YPSVIPFDGG---DYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQE
|.  ||. |.    .  .||| .  |    .  .|  . .|. ||    |||||.. |.... .||| || || .|...|| .. ...  .||||..|.|
gfkeeyeslfegwdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelve

DT-LTYPQYWPSEGSEtYDHLNVRLMSREKQGKLISRKLAIGQ--KGVEGEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQcGDKAIAVQCSNG
 . .   .||| ...  |....| |.. | . .|..| ... .  .|.|. .|| ..|.. |||   ||. ...|.||  |. ||.. ..  | | ||.|
vgrvkClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaG

VGRSGTFCAIYSLLERIKAEQVVDVFQTVKVLRLGRPGAVETLTQYIYCYQMV
 ||.|||.|| ..|. |. |.|||||..|| ||  ..  |||  ||...|...
aGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvi
0037934 (Phosphotyrosine protein) phosphatases II 114-338 4.9e-58 191.9 In-house 5-241 (243) alignment 
Range on Protein: 114-338
Range on HMM: 5-241/243.0
GRADYNIKKNRYPSVIPFDG-------GDYINASFADAFRKrnaFILTQAPLGHTMAE----FWHMICQYKIGTIVMLNNLQ-EDTLTYPQYWPseGSET
..  .|..||||....|.|        .|||||.. . ...   .|.||.|| .| ..    ||.|. ...|..||||..|.  . . ..||||  |..|
allpenlsknrysdilpydhsrvklegsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gevt

YDHLNVRLMSREKQGKLISRKLAIGQKG-VEGEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQ-------CGDKAIAVQCSNGVGRSGTFCAIY
|... |.|.| |  .. . |.| .  ..  . ...|.|.... ||| ..| .....||....|.  ...        ... ..| || ||||.||..|.|
ygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaay

SLLERIkaeQvVDVFQTVKVLRLGRPG-AVETLTQYIYCYQMVQRY
 .|...   . ||....|| ||  ||| ||.|. ||...|.... .
lmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Ptp69D_pd Subfamily Ptp69D 86-340 9.4e-57 187.5 In-house 18-287 (307) alignment 
Range on Protein: 86-340
Range on HMM: 18-287/307.0
TQNLSGYALEYQRLLAVssqIEDENSKVGRADYNIKKNRYPSVIPFDG-------------GDYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQY
 .   |.| ||..| |      | ..||.  . |  ||||. ...||               |||||||  ...... ||  |.|.  |. .|| || . 
rdtdfglakeyekLear...eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeq

KIGTIVMLNNLQEDTLT-YPQYWPSEGSETYDHLNVRLMSREKQGKLISRKLAIGQKG-----VEGEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQ-L
.. .|||| ||.| .    ..||| |    |....|.|.| ||... | |.| . .|.     || ...||  .. .|.|  .|   ...|.|.. |. |
evtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrel

SQQQcgDKAIAVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTVKVLRLGRPGAVETLTQYIYCYQMVQRYLD
 ...     | | ||.||||||.| |. |||...|||. ||.|.||| ||  |.  |. | ||...|. .  | .
ykln..rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 134-345 6.8e-55 181.0 In-house 76-289 (290) alignment 
Range on Protein: 134-345
Range on HMM: 76-289/290.0
GDYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQED-TLTYPQYWPSEGSETYDHLNVRLMSREKQGKLISRKLAIGQKGV-E
 .||||.. . .......|.||.|. .|...||..| | |.  |||| | .|. . .  ||||......|.. ...|.. |.  . | ||| . .|   .
neyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsag

GEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQCGDKAIAVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTVKVLRLGRPGAVETLTQYIYC
 ...|.. |   |...    |.|..| ... ..  | . |...| | ||..||||..|||..  ... | |.|.|||| .| .|  .|| |.|  || . 
akqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgi

YQMVQRYLDSFSDY
.|.| .|||||. |
fqivltyldsfety
subfamily_PTPRG_pd Subfamily PTPRG 90-340 1.6e-54 180.1 In-house 19-288 (563) alignment 
Range on Protein: 90-340
Range on HMM: 19-288/563.0
SGYALEYQRLLAvSSQIEDENSKVGRADYNIKKNRYPSVIPFDG-------------G-DYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYKIG
 |.. |.. |    .. .| . .  ..  | .|||| .....|                |||||.. | ..| .||| || || .|.  ||.|| . .  
igfseefealqs.etiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnva

TIVMLNNLQEDT-LTYPQYWPSEGSETYDHLNVRLMSREKQGKLISRKLAIGQ------KGVEGEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQ
.|||. ||.|..    ..|||...||||..|.|.|...|.     .|.| | .      |  . |..| . .  .|||...|     ||  |   . ...
iivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaank

Q-CGdkAIAVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTVKVLRLGRPGAVETLTQYIYCYQMVQRYLD
.  |   | | ||.||||.||.... .||..|..|..|.||...| .|. |.  |.|  |||. .. ..  . 
aeaG..PivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaia
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 109-348 1.4e-53 176.7 In-house 37-287 (287) alignment 
Range on Protein: 109-348
Range on HMM: 37-287/287.0
ENSKVGRADYNIKKNRYPSVIPF---------DGGDYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQEDT-LTYPQYWPSEG
..  .. |  | .|||.  ...             |||||.| |......|||....|. .|. .||..| . .. .|||| ...|..     ||||.| 
devthniasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeek

SETYDHLNVRLMSREKQGKLISRKLAIGQKGVEGE-HEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQCGDKAIAVQCSNGVGRSGTFCAIYSLLE
| .. . |..|...|.. . | ||| . .|. .|. ..|.  |  .|...    ..|..| ..     .|.. |. .| | ||..||||..|||.   ..
svvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattin

RIKAEQVVDVFQTVKVLRLGRPGAVETLTQYIYCYQMVQRYLDSFSDYANF
. | | |.|||| .|  |  .||.| | .||.. ...|. |||||. |..|
kckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysdf
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 110-340 6.5e-51 168.0 In-house 35-278 (315) alignment 
Range on Protein: 110-340
Range on HMM: 35-278/315.0
NSKVGRADYNIKKNRYPSVIPFDG-------------GDYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQE-DTLTYPQYWP
. .|.| . | |||||  ..|.|               ||||||.  .. . .|.| .|.||  .. .||.|. |.|. ||||....|| | .   ||||
rqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywP

S--EGSETYDHLNVRLMSREKQGKLISRKLaIGQKGvEGEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSqQQCGDKAIAVQCSNGVGRSGTFCAIY
     |  .  ..| |.| | ..  . ||| . .|. |  . |   |  ||||| .. .  |.| |.  |. . ..  . .. | || ||||.| ...| 
drkadsvefGsikvellsleadtdgvarkl.vtrks.eesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvisid

SLLERIKAEQVVDVFQTVKVLRLGRPGAVETLTQYIYCYQMVQRYLD
. ...|| ...||||..|| ||  ||  | |  .| . |. |. .| 
evvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 77-341 6.9e-51 168.0 In-house 2-278 (281) alignment 
Range on Protein: 77-341
Range on HMM: 2-278/281.0
MRKRAAVKPTQNLSGYALEYQRLLAVSSqieDENSKVGRADYNIKKNRYPSVIPFDG-------------GDYINASFADAFRKRNAFILTQAPLGHTMA
.||... . ... .|.. ||. | |.     |. ..  .|| |..||||  .. .|               |||||.| ..... ...| ||.|. ....
lrkhlkqlsqndnaGfieeyeklaaigv...dntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslv

EFWHMICQYKIGTIVMLN-NLQEDTLTYPQYWPSEG-SETYDHLNVRLMSREKQGKLISRKLAIGQKGVEgEHEVVHIQHIEWPDKCAPVNHQSVLDLVS
.||.|. ..|. .|||.  ..... |   .||| .  . .| .. |. ...|.. . |.||. . ... | . ||...... |||. .| . . .|.  .
afWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresge.treveqlaytaWPdhGvPattkellefrk

WVQLSQQQCGDKAIAVQCSNGVGRSGTFCAIYSLLERIKAE-QVVDVFQTVKVLRLGRPGAVETLTQYIYCYQMVQRYLDS
 |.  ...  . .. . || ||||.||. |.  |.....|| . .|| ..|. ||  |   | |..|| . |..| ..|| 
evlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_CG7180_pd Subfamily CG7180 81-339 3.3e-50 165.4 In-house 4-290 (296) alignment 
Range on Protein: 81-339
Range on HMM: 4-290/296.0
AAVKPTQNLSGYALEYQRLLAVSSQIEDENSKVGRADYNIKKNRYPSVIPFDG-------------GDYINASFADAFRKRNAFILTQAPLGHTMAEFWH
. .| ...   . .||. .| . ...| .. . |    |..|||.. |.|.|               |||||.. |.| | ...| |.||  .|. ||| 
kflklvdkrrkfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWr

MICQYKIGTIVMLNNLQEDTLTYPQYWPSEGSETYDHLNVRLMSREKQGKLISRKLAIGQK---------GVEGEHE-VVHIQHIEWPD-KCAPVNHQSV
.. . .| ..|.| .  . .  ||.||| .. | | .. | ... ..  .| .|.. . .|         .|. |   | ..|  ||.  .  |.  ...
lvydeeisavvvLtktfdfakmypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnal

LDLVSWVQLSQQQC----GDKAIAVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTVKVLRLGRPGAVETLTQYIYCYQMVQRYL
..|.  |.| ...       . . | .|.|..||| ..||   || .. |. ||||. || ||  ||. ||. ..| |.|.... ..
ielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_PTPRB_pd Subfamily PTPRB 89-340 6e-50 164.9 In-house 24-286 (293) alignment 
Range on Protein: 89-340
Range on HMM: 24-286/293.0
LSGYALEYQRLLAVSSqieDENSKVGRADYNIKKNRYPSVIPFD-------------GGDYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYKIG
  ... ||..| || .   |.. |. ..  | .||||  ..|.|             | |||||.. . .. .. || || || .|. .||.|. . |  
dlrfseeyeelkavgk...dqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkss

TIVMLNNLQEDTL-TYPQYWPSE-GSETYDHLNVRLMSREKQGKLISRKLAIGQkgVEGEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQ-QQCGD
.|||| .| |       .|||..  . .| ...| |.. |.. . . |.|.| .   . |..| . ... |||   | . ...||.|  |. .. ... .
iivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektask

KAIAVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTVKVLRLGRPGAVETLTQYIYCYQMVQRYLD
. | | || ||||.||| |.  ||..|. |..||.| .|  ||  |   | | .|||. .| |...| 
rPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 82-341 6.1e-50 165.2 In-house 15-291 (325) alignment 
Range on Protein: 82-341
Range on HMM: 15-291/325.0
AVKPTQNLSGYALEYQRLLAVSSQiedeNSKVGRADYNIKKNRYPSVIPFDG-------------GDYINASFADAFRKRNAFILTQAPLGHTMAEFWHM
  | .|.  |.| |.. | .. ..      ||     |..|||.. |...|               ||||||.   ..|.. |. .|||| .|. ..| .
ekkkaqdqdgfahefgllpsddgi....akkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrl

ICQYKIGTIVMLNNLQEDTLTYPQYWPSE--GSETYDHLNVRLMSREKQGKLISRKLAIGQKGvEGEHE-VVHIQHIEWPDKC---APVNHQSVLDLVSW
.....   .|.|| |...     .||| |   | |.  |.|.|.. |.    . |.| . |   .||   |   |.  |.|      |    |.|.||  
vldWrcsvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvk.kGetrsvkqfqlqswddmGvqkrpatlisilqlvka

VQLSQ--QQCGDKAIAVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTVKVLRLGRPGAVETLTQYIYCYQMVQ-RYLDS
|.     .  .   | | ||.||||.|.| ..||.|...  |  ||.|. || ||  ||  |||  ||| .|. .   |. .
vservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsg
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 133-341 1.1e-49 164.1 In-house 78-286 (297) alignment 
Range on Protein: 133-341
Range on HMM: 78-286/297.0
GGDYINASFADAFRKrnAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQEDTLTYPQYWPSEGSETYDHLNVRLMSREKQGKLISRKLAIGQKGVEG
  ||.||||  ....   .| || |   |.|.|| |. .... ||||||...| .    .||. .|. |. .. | |.| ...   | |.| . .     
dsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkaka

EHEVVHIQHIEWPDKCAPV--NHQSVLDLVSWVQLSQQQCGDKAIAVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTVKVLRLGRPGAVETLTQYIY
.. |   |..|||||  .   . .|.|.|.| |. . .|  .  . | |..|||| | ...| | . ..| |. ||.|..|| ||  ||  | |  || .
rrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykf

CYQMVQRYLDS
 |..|  .| |
vyvavlealls
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 87-346 3.1e-49 163.0 In-house 31-299 (319) alignment 
Range on Protein: 87-346
Range on HMM: 31-299/319.0
QNLSGYALEYQRLLAVSSQIEDENskVGRADYNIKKNRYPSVIPFD-------------GGDYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYK
..|. .  |..|.  .. .  | .      | |  |||.  ...||             . ||||||| . ..... .| .| ||  |.|.|| || .|.
ddltklevefrracklgvnladqt..fanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyn

IGTIVMLNnlqedTLTYPQYWPSEGSETYDHLNVRLMSREKQGKLISRKLAIGQKGVEGEHE-VVHIQHIEWPDKCAPVNHQSVLDLVSW-VQLSQQQCG
. |||.|           |||| .. ..... .|.. | |.  . . |.. . ..| | .   .       |||.  |     .. ||     | ... .
cstivllt.....kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenh

DKAIAVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTVKVLRLGRPGAVETLTQYIYCYQ-MVQRYLDSFSDYA
 . | | || ||||.|.. ..  ||.|.| |. |||...|. ||  |.  |. |.|| ..|  ... .| ..|| |
ranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdva
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 135-347 8.2e-49 160.9 In-house 71-301 (301) alignment 
Range on Protein: 135-347
Range on HMM: 71-301/301.0
DYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQEDTL-TYPQYWPSEGSETYDHLNV--RLMSREKQGKLISRKLAI------
.|||||. |.......|| .|.|. .|...||..| |.|  .|||. ||.|.|     ||||.   |...  ..   |..       . |.|..      
eyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgs

-----------GQKGveGEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQCGDKAIAVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTVKVL
            ..     ..|. .| ..||.     ... ||  .  |   ||. |   . | ||..|.|||..|..   ||  ||| |||||| .| .
nngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkav

RLGRPGAVETLTQYIYCYQMVQRYLDSFSDYAN
|  .|||| || ||.  |.....||   | |||
rrskpgaVtTLeqytsiydvidmylqlnstyan
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 123-346 2e-48 160.3 In-house 42-263 (284) alignment 
Range on Protein: 123-346
Range on HMM: 42-263/284.0
NRYPSVIPFDGGDYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNnlqedTLTYPQYWPSEGSETYDHLNVRLMSREKQGKLISRK
 .   .|  .. |||||||   ..... .| || ||  |.|.|| || .|.. |||.|           |||| .. ..... .|.. | |.  . . |.
vklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.....kdkcsqywplkivikeerfkvkvdsveeseeyvvrd

LAIGQKGVEGEHE-VVHIQHIEWPDKCAPVNHQSVLDLVSW-VQLSQQQCGDKAIAVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTVKVLRLGRPG
. . ..| | .   .       |||.  |     .. ||     |.... . . | | || ||||.|.. ..  ||.|.| |. |||...|. ||  |. 
ielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrnt

AVETLTQYIYCYQ-MVQRYLDSFSDYA
 |. |.|| ..|  ... .| ..|| |
lvqdlvqykfiysalleehlfghsdva
subfamily_PTPN12_pd Subfamily PTPN12 87-339 6.1e-47 154.9 In-house 5-277 (290) alignment 
Range on Protein: 87-339
Range on HMM: 5-277/290.0
QNLSGYALEYQRLLAVSSQIEDEN---SKVGRADYNIKKNRYPSVIPFD-------------GGDYINASFADAFRKRNAFILTQAPLGHTMAEFWHMIC
..   .| |.|.| ..|..  .|.   ...|....|.|||||  ..|.|             | |||||.|     .. ..| .|.|| .|. .||.|| 
egeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiw

QYKIGTIVMLNNLQE-DTLTYPQYWPSEGSET--YDHLNVRLMSREKQG-KLISRKLAIGQKgvEGEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLS
....  .||. .. | .     .|||.|| |.  .....| |.. ..    .. | |.. ..  . ...|  ... .|||.  | ...|.|.|.. |.  
eknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrel

QQqCGDKAIAVQCSNGVGRSGTFCAIYSLLERIKAEQV---VDVFQTVKVLRLGRPGAVETLTQYIYCYQMVQRYL
|.   |. ..| || |||| || .||    | .|||..   .|||. |  ||  |. .| |  || . |. |  ..
qe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 135-339 2.7e-46 152.7 In-house 72-276 (515) alignment 
Range on Protein: 135-339
Range on HMM: 72-276/515.0
DYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQE-DTLTYPQYWPS--EGSETYDHLNVRLMSREKQGKLISRKLAIgQKGVE
||.|||.  .|   .|.| .|.|.  .. .||... |... ||.|...|.| |     .|||     |  . ...| |.| |  .  | ||| .  || .
dyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltv.lkgdd

gEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQCGdKAIAVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTVKVLRLGRPGAVETLTQYIYC
  . |   .  ||||| .| . .|.| |.  |. ...|    .. . || |||| | ...| | . ..|  ..||||..|...|  ||  | |  || . 
.srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafi

YQMVQRYL
|..|. .|
ygavledl
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 105-335 1.4e-45 150.4 In-house 19-262 (283) alignment 
Range on Protein: 105-335
Range on HMM: 19-262/283.0
QIEDENSKVGRADYNIKKNRYPSVIPFD---------GGDYINASFAD---AFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQEDT-LTYP
 . | ....  || | .|||.  ..| |           |||||.|       .. . .| .|.|| .|. .||.|. . || .|||| .||||      
svpdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCs

QYWPSEGSETYDHLNVRLMSREKQGKLISRKLAIGQK-GVEGEHEVVHIQHIEWpDKCAPVNHQSVLDLVSWVQLSQQQCGDKAIAVQCSNGVGRSGTFC
||||..||| |  . | |     .  .| ..| . ..   . .  . | | |.|  .. .      |  .  |.  |..  .  | | ||.|.||...|.
qyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW.leygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfi

AIYSLLERIKAEQVVDVFQTVKVLRLGRPGAVETLTQYIYCYQMV
|. . .. ...| |||||..||..|  |..|| || ||   ...|
aasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 132-335 1.9e-44 146.8 In-house 75-275 (315) alignment 
Range on Protein: 132-335
Range on HMM: 75-275/315.0
DGGDYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQEDTLTYPQ-YWPSEgSETYDHLNVRLMSREKQGKLISRKLAIGQKgv
.. ||.||.| | . |.. .| .|.|.  .. .|| .. ...||.||||.|| |.     . ||| .   .| .. | ..| |.. ..  | |..  .  
phsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtlsvvfg..

EGEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQCGdKAIAVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTVKVLRLGRPGAVETLTQYIY
.  .||| ...  |||   |    ....|.  |.  ...    || | ||.||||.|||... ..|....||...||.. .. .|  | ..|... || .
dnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqf

CYQMV
 |...
iydal
subfamily_PTPN6_pd Subfamily PTPN6 88-341 6.1e-44 145.2 In-house 24-299 (306) alignment 
Range on Protein: 88-341
Range on HMM: 24-299/306.0
NLSGYALEYQRLLAVSSQIEdENSKVGRADYNIKKNRYPSVIPFD------------GGDYINASFAD--AFRKRNAFILTQAPLGHTMAEFWHMICQYK
. .|.  |...|    ..    . | |.   | .|||| ...|||            | |||||.. .  .  .....| ||  | .|...||.|. | .
ekagfeeefeelqqeeakkl.lsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqen

IGTIVMLNNLQED-TLTYPQYWPSEGS-ETYDHLNVRLMSREKQGKLISRKLAIG-QKGVEGEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQC
   |||. .  |       .|||.| . |.| ...|. .| ... . | |.| .  .|  . |.||.. .. .|||.  | . . |||... |.  |...
srvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeel

G---DKAIAVQCSNGVGRSGTFCAIYSLLERIKAE---QVVDVFQTVKVLRLGRPGAVETLTQYIYCYQMVQRYLDS
      .| | ||.|.|| |||  |  ||. |. .     .|. ..||..|  | | | | .|| . |.... |...
eeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
subfamily_PTPN23_pd Subfamily PTPN23 93-339 1.4e-43 143.8 In-house 18-280 (288) alignment 
Range on Protein: 93-339
Range on HMM: 18-280/288.0
ALEYQRLlAVSSQIEDENSKVGRADYNIKKNRYPSVIPFDG---------GDYINASFADAFR-KRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNN
  ... |   . . | ..  .  |  . .|||.  ..|.|           |||||||          || |||||  |...|| |. . |  .|||| .
dkkfkel.eqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmlls

LQEDTLT-YPQYWPSEGSE--TYDHLNVRLMSREKQGKLISRKLAIGQKGVEGEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQL---SQQQCGDKAIA
 .|   .   .|||..  |  ....|.| | | .. .. . |.| .  ....  ..|.|.|  .||.  .|   ...|...  |.    ..|.  .. . 
keelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlv

VQCSNGVGRSGTFCAIYSLLERIKAEQ-VVDVFQTVKVLRLGRPGAVETLTQYIYCYQMVQRYL
|.|| ||||.|.|. .|. .. ..... ..|. | |. ||  |   |.. .|.  .|..| .. 
vhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 133-340 2e-43 143.4 In-house 56-269 (274) alignment 
Range on Protein: 133-340
Range on HMM: 56-269/274.0
GGDYINASFADAFR-KRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQEDTL-TYPQYWPSEG----SETYDHLNVRLMSREKQGKLISRKLAIG
  .|||| .   .. . .|.. || || .|.|.||.|| | ..  |||| .|.|       .|.| .     ||.|......  .  .. .   ||| . 
dssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlk

QKGVegEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQCGDK--AIAVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTVKVLRLGRPGAVET
.     |..|.|. . .|||. .| . ...||||  |. |...   |  .. | || |.|| | | ||   . ....|.||||...|  ||| | | |.|
yler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqt

LTQYIYCYQMVQRYLD
  || . ....  || 
seqyelihralclylk
subfamily_PTPN9_pd Subfamily PTPN9 123-338 3.7e-43 142.7 In-house 46-289 (297) alignment 
Range on Protein: 123-338
Range on HMM: 46-289/297.0
NRYPSVIPF-------------DGGDYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQED-TLTYPQYWP--SEGSETYDHLN
|||  |. .             .  |||||.| | .....||| || || .|. .|| |. . .. .|||   . |   |   ||||  .| |. . .|.
nrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdls

VRLMSREKQGKLISRKLAIGQKGVEGEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQ------------QCGDKAIAVQCSNGVGRSGTFCAIYS
|. .. |.. .   |.| | .   | . .|.| | . |||   | . .|.||... |.  |             .. .  | | || |.||.|||...  
vsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldi

LLERIKAEQVVDVFQTVKVLRLGRPGAVETLTQYIYCYQMVQRY
 |.|.. ...|||..||| ||  |  .. |  || .||. |  |
clsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 102-338 5.1e-43 142.0 In-house 25-258 (267) alignment 
Range on Protein: 102-338
Range on HMM: 25-258/267.0
VSSQIEDENSKVGRADYNIKKNRYPSVIPFDGGDYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQEDTLtyPQYWPSE--GS
.|  |  .| .  | |.|.  .    ..     .|||||. ......||||.|| ||  |...|. .| ..|. .||.| .  .| .  ...|| .   .
isqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdni..rlfwPPkmgqa

ETYDHLNVR--LMSREKQGKLISRKLAIGQkgvEGEHEVVHIQHIEWPDKCapVNHQSVLDLVSWVQLSQQQCGDKAIAVQCSNGVGRSGTFCAIYSLLE
. |. | |   |   |.. ..|. .| . .   |  |.|.   . .|  .    |.  .  |.  .   | . |.. . |.||.||||||||  |.| ||
kkyqdltvehslekeendyqiitlelkfkn...esahnvtlyyykkwnint..nnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqle

RIKAEQVVDVFQTVKVLRLGRPGAVETLTQYIYCYQMVQRY
|.| |.|.|.|. .. .|  |.| |.|. .|||.....  |
raktegvsdifdflrkirsqriglvdtkeryiyihellaey
subfamily_PTPN13_pd Subfamily PTPN13 109-340 7.5e-43 141.8 In-house 27-270 (273) alignment 
Range on Protein: 109-340
Range on HMM: 27-270/273.0
ENSKVGRADYNIKKNRYPSVIPFD--------GGDYINASFADAFRKRN--AFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQE-DTLTYPQYWPSE
....||. . | .||||  |.|.|         | |||||.  .    .   .|..| || .|...|| |. . |   |.|. . .| . .   .|||..
dtcevgkkkenkdknryrnvlPydetrvklgdeggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPes

GSET---YDHLNVRLMSREKQGKLISRKLAIGQKGVEGEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQqcGDKAIAVQCSNGVGRSGTFCAIYS
 ...   .. |.|.|.  .|.  .  |.||. ..  .  .||.|.. ..|||   | . ...| .|. |.  |.      |.| || |.|||||. .|. 
knkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrsGtlitidv

LLERIKAEQVVDVFQTVKVLRLGRPGAVETLTQYIYCYQMVQRYLD
.|. |. .. .|| ..|. ||  | | | |  |||..|. .   | 
vlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
0036282 (Phosphotyrosine protein) phosphatases II 133-333 9.8e-43 141.2 In-house 1-164 (174) alignment 
Range on Protein: 133-333
Range on HMM: 1-164/174.0
GGDYINASFADAFRKRNAFILTQAPLGhtmaeFWHMICQYKIGTIVMLNNLQEDT-LTYPQYWPSegsetydhlnvrlmsrekqgklisrklaigqKGVE
| ||||||. | ..  . .|..|.||      ||.|.....| |.|||....|.     ..|||.                               .   
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lred

GEHEVVHIQHIEWPDKCAPVNHQsVLDLVSWVQLSQQQCGDKAIAVQCSNGVGRSGTFCAIYSLLERIKaEQVVDVFQTVKVLRLGRPGAVETLTQYIYC
 |......... ||| ..|  .. .|..|..|.  ....... ..| || ||||.||..|.| .| ... | .||....|. ||| |||.|.|  ||...
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfl

YQ
|.
yy
0041856 (Phosphotyrosine protein) phosphatases II 119-337 5.3e-42 138.8 In-house 1-169 (182) alignment 
Range on Protein: 119-337
Range on HMM: 1-169/182.0
NIKKNRYPSVIPFDGG---DYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNnlqedtltYPQYWPSEGsetydhlnvrlmsrekq
|..||||. ..|.| .   |||||.. .  .. . ||.||.|| .|.|.|..|. ...|.|||.|.         ..|||..                  
nldknrysdilpydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt........eelywpell.................

gklisrklaigqkgvegEHEVVHIQHIEWPDKCAPVnHQSVLDLVSWVQLsqqqcGDKAIAVQCSNGVGRSGTFCAIYSLLERikaeQvVDVFQTVKVLR
                 |......... ||| ..|   ...||.. .|.       .....| || ||||.||..|.| ....    . |.....|| .|
.................erlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvr

LGRPGAVETLTQYIYCYQMVQR
  |||.|.|. ||.......  
srRpgmvitpnqyfflqlalle
0051429 (Phosphotyrosine protein) phosphatases II 133-342 1.1e-41 138.7 In-house 3-228 (272) alignment 
Range on Protein: 133-342
Range on HMM: 3-228/272.0
GGDYINASFADAFRK---RNAFILTQAPLGHTMAEFWHMiCQYKIGTIVMLNNLQEDTLTY-PQYWP------------SEGSETYDHLNVRLMSREKQG
 ..||||.. . . .   .........|| .| |.||.. ....| |||.| .. |      ..|||            |. . .| .| |.|.| | . 
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

KLISRKLAIGQK-GVEGEHEVVHIQHIEWPDKCAPVNHqsVLDLVSWVQLsqqqcgDKAIAVQCSNGVGRSGTFCAIYSLLERIKAEQVVD--------V
  | |.| .  . . .  .|| |.... ||| ..| .   .|.|.....       .... | || |..|.||..|.. ||... .|..||        .
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

FQTVKVLRLGRPGAVETLTQYIYCYQMVQRYLDSF
...|. ||  |||||.| .||...|. .. .|.|.
eeaveelraqrpgavqteeqylflyeallellrsl
0043147 (Phosphotyrosine protein) phosphatases II 133-336 6.5e-41 135.3 In-house 4-158 (172) alignment 
Range on Protein: 133-336
Range on HMM: 4-158/172.0
GGDYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLqedtltypqywpsegsetydhlnvrlmsrekqgklisrklaiGQKGVEG
| ||||||. |  .. . || ||.||..|.|.||.|. ...|..||.|..|                                             .   
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..........................................lydpell

EHEVVHIQHIEWPDKCAPvNHQSVLDLVSWVQLSQQQCGDKAIAVQCSNGVGRSGTFCAIYSLLerikaeQVVDVFQTVKVLRLGRPGAVETLTQYIYCY
|......... ||| ..| . . .|.......  .... .....| || ||||.||..|.| .|      . ......|. .|  |||||..  ||...|
erlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrfly

QMVQ
.  .
yfek
subfamily_PTPN3_pd Subfamily PTPN3 111-338 6.8e-41 135.0 In-house 33-275 (280) alignment 
Range on Protein: 111-338
Range on HMM: 33-275/280.0
SKVGRADYNIKKNRYPSVIPFDG---------GDYINASFAD----AFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQEDTL-TYPQYWPS
 .. |   |..||||  ..|.|           |||||.. .    .    | .| || || .|...||.|. . |. .|||| .| |.      ||||.
isaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe

EGS-ETYDHLNVRLMSREKQGKLISRKLAIGQKGVEGEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSqQQCGDKAIAVQCSNGVGRSGTFCAIYSL
..   .| ...|.. ..... . . |.| . .|  . |......|...|||.. | .....|..|. |.   ..  .. . | || |.||.| . ..   
tedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrkl.rsgkeePvvvhCsaGigrtGvlilleta

LERIKAEQVVDVFQTVKVLRLGRPGAVETLTQYIY-CYQMVQRY
|  | |.. | . . |. .|  |   |.| .|| . |  ... |
lalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvy
0046846 (Phosphotyrosine protein) phosphatases II 128-340 5.4e-38 125.8 In-house 6-174 (176) alignment 
Range on Protein: 128-340
Range on HMM: 6-174/176.0
VIPFDGGDYINASFADAFRkrnaFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQEDTLTY-PQYWPSEGSETYdhlnvrlmsrekqgklisrklaig
 ... . |||||....  |    .| ||.|| .|.|.|..|. ...|...|.|....|      |.||| . .. .                        
lgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi........................

qkgvegehevvHIQHIEWPDKCAPVNhQSVLDLVSWVQLSQQQcgDKAIAVQCSNGVGRSGTFCAIYslleRIKAEQVVDVFQTVKVLRLGRP-GAVETL
           ...|. ||| ..|   . .|.|. ...  ...  .. ..| || |.||.||..|.|     .. |. ..|..... .|  || |||.| 
...........qylhlpwpDhgvpdl.elllellefirealke..ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtp

TQYIYCYQMVQRYLD
 || ..|......|.
eQyrflyefellllk
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 134-340 1e-36 121.3 In-house 48-265 (270) alignment 
Range on Protein: 134-340
Range on HMM: 48-265/270.0
GDYINASFADAF-RKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQEDTLT-YPQYWPSEGSE----TYDHLNVRLMSREKQGKLISRKLAIGQ
  |||| .   |  .....| ...||  |. .|| || . |  .|||. .|.|.  .   .|||.|  |    .. ...|. .| ||.   | ..| . .
taYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrlee

KGVegEHEVVHIQHIEWPDKCAPVNHQ------SVLDLVSWVQLSQQQCGDK-AIAVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTVKVLRLGRPG
||   |...|| .. .|||. .| ...      ..| ..  |. |...  ..  . | ||.||||.||. |.   .. .. .. ||| . .. ||  |. 
kge..errlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRma

AVETLTQYIYCYQMVQRYLD
 |..  || . |. |. | .
lvqhpeqyeflykavveyae
0049260 (Phosphotyrosine protein) phosphatases II 143-333 3.4e-36 119.6 In-house 3-144 (152) alignment 
Range on Protein: 143-333
Range on HMM: 3-144/152.0
DAFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQEDTLT-YPQYWpsegsetydhlnvrlmsrekqgklisrklaigqkgvegehevvHIQH
| ... ..|| ||.|...|.|.||.|. ...|.|||||..|.|..    .||.                                           ...|
dgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qylh

IEWPDKCAPVNHQSVLDLVSWVQLSqQQCGDKAIAVQCSNGVGRSGTFCAIYSLLerikaeQVVDVFQTVKVLRLGRPGAVETLTQYIYCYQ
. ||| ..| ..| .|.|. ...   ..  .. ..| || ||||.||..|.| .|      . |.....|. .|  |||||..  |....|.
lpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
0049772 (Phosphotyrosine protein) phosphatases II 113-343 2.1e-35 118.4 In-house 40-284 (314) alignment 
Range on Protein: 113-343
Range on HMM: 40-284/314.0
VGRADYNIKKNRYPSVIPFD-----------GGDYINASFADAFrkrNAFILTQAPLGHTMAEF----------WHMI--CQYKIGTIVM----------
|..   |..||||. ..|.|           | ||||||. | |   ..|| ||.|| .|.  |          |.|.   .... .|||          
vadlflnrdknryldilpadnrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladel

-----------LNNLQEDTltypqywPSEGSETYDHLNvrlmsrekqgklisrklAIGQKGVEGEHEVVHIQHIEWPDKCAPvNHQSVLDLVSWVQLSqq
           |..| . .       .    .....|.                  .   .   |.....  .| .|| .||   . ..... ...    
srLdaAlgKtpllildgng.......neptaadlellk.................eelydpelferlgikylripvpDgsap.lledfdeflefieea..

qCGDKAIAVQCSNGVGRSGTFCAIYSLLERIKaeqvVDVFQTVKVLRLGRP-----GAVETLTQYIYCYQMVQRYLDSFS
   .....| |. |.||.|||.... |. . .    |.. .... .|| ||     |..|.| ||..... .. ||. . 
.dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefilealleylkflk
subfamily_PTPN1_pd Subfamily PTPN1 105-335 3.5e-35 116.1 In-house 18-267 (290) alignment 
Range on Protein: 105-335
Range on HMM: 18-267/290.0
QIEDENSKVGRADYNIKKNRYPSVIPFDG---------GDYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQED-TLTYPQYW
. .| . .. . . | ..|||  | |.|           ||||||. .. . .  .|||| || .|.. ||.|. . |  ..||||.. |  ..   |||
easdfptreaklpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqyw

PSEGS---ETYD--HLNVRLMSREKQGKLISRKLAIGQKGVEGEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQCGDKAIA-VQCSNGVGRSGT
|.. .    ...  .|.|.|.|.|.. . . |.| . ..  .  .|..|  .. |||   |   .. |...  |. |     |.  | . || |.|||||
PqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGt

FCAIYSLLERIKAEQV---VDVFQTVKVLRLGRPGAVETLTQYIYCYQMV
|| . ..| .|....    ||. ...  ||  | | . |  |  . |. .
fclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylai
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 116-336 5.7e-35 115.6 In-house 45-276 (439) alignment 
Range on Protein: 116-336
Range on HMM: 45-276/439.0
ADYNIKKNRYPSVIPFDGG-------------DYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQEDTLtypqYWPSEGSETY
 .|.  |||| .| .|| .              |||| . . . . . .| ||.|  .|  .|| .. . |  ||||| || |       ||||..   |
qeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk....ywpsdaevcy

DHLNVRLMSREKQGKLISRKLAIGQKGVEG--EHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQCGDKAIAVQCSNGVGRSGTFCAIYSLLERIK
  . ||     .  . . | . . ..   .  |. |.....| ||||  | .   |||..  .. ....     . |.|| ||||.||  |.   ||..|
gdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlk

AEQVVDVFQTVKVLRLGRPGAVETLTQYIYCYQMVQ
.|. ||.   |||||  |   |..| ||.. |. | 
lenkvdikgivkvlrkqrkqmvqalcqyvfiynavl
subfamily_PTPRN_pd Subfamily PTPRN 105-336 6.5e-35 115.3 In-house 42-289 (297) alignment 
Range on Protein: 105-336
Range on HMM: 42-289/297.0
QIEDENSKVGRADYNIKKNRYPSVIPFDG-------------GDYINASFA-DAFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQEDTLT-
. |.. ..|..|. |.||||. .|.|.|               ||||||.  |   .. |.| ||.|| .|.|.|| |. .  .  ||.| .|.|. .. 
eaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkq

YPQYWPSEGSETYDHLNVRLMSREKQ-GKLISRKLAIGQKGVEGEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQcGDKAIAVQCSNGVGRSGT
  .||| ||||.|.  .|.|.|        . | . . .   .    |    .. ||.. .| . .|.|..   |. | .     .| | ||.|.||.|.
ckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG.rscpivvhcsdGaGrtGv

FCAIYSLLERI-KAEQVVDVFQTVKVLRLGRPGAVETLTQYIYCYQMVQ
...|  .|.|. |  . .|.  |.. ||  ||| |.|  |. .... | 
yilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltava
subfamily_PTPN14_pd Subfamily PTPN14 103-340 4e-33 109.7 In-house 33-297 (300) alignment 
Range on Protein: 103-340
Range on HMM: 33-297/300.0
SSQIEDENSKVGRADYNIKKNRYPSVIPFDG------------GDYINASFADAF--RKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQEDTL
. . || . .... . | .|||.. |.|..              .|||||   .    |.  .| .|.|| .|. .||.|. . ..  |||| . .||  
pkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgk

TY-PQYWPSEGS----ETYDHLNVRLMSREKQGKLISRKLAIGQKGVEGEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQCGDK--------AI
.   .|.|...|     .... .|    .|. ...| ..| .     . | .|.|.|...|||.  | . .. |. .  ||  ...  ..         .
eksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPv

AVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTVKVLRLGRPGAVETLTQYIYCYQMVQRYLD
 | ||.||||.|       |.. .. ....|. .... ||  |   |.||.|| . |... .||.
lvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 91-338 3.3e-32 106.3 In-house 28-282 (290) alignment 
Range on Protein: 91-338
Range on HMM: 28-282/290.0
GYALEYQRLLAVS-------SQIEDENSKVGRADY-NIKKNRYPSVIPFDG--GDYINASFADAFrkRNAFILTQAPLGHTMAEFWHMICQYKIGTIVML
..| ||   |           .| |.|... .  | ..  |    ||  ||  |||. | . .    .  ||||| .|  |. ..| |. | |. .||||
elakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivml

NNLQEDTLT-YPQYWPSEGSE--TYDHLNVRL-MSREKQGKLISRKLAIGQKGVEGEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVqlsQQQCGdkAIA
 .| ||  .   ||.| .  |  |. .. |   .. .|. ..| . |.. .|    || . |.. . ||||. .    ..| ..  .   ..  |   ..
celiedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlril...rkasG..pvv

VQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTVKVLRLGRPGAVETLTQYIYCYQMVQRY
| || |.||.||| ||   |. .   . .|. ..|. ||  | ..|.  .||.   ...  .
vhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 110-336 6.9e-32 105.3 In-house 36-233 (392) alignment 
Range on Protein: 110-336
Range on HMM: 36-233/392.0
NSKVGRADYNIKKNRYPSVIPFDG-------------GDYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQEDTltypqywps
. .|.. . |.|||||  ..|.|               ||.|||. ..|   .|.| .|.|   .. .||.|. | .. ||.|...|.|           
pqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.........

egsetydhlnvrlmsrekqgklisrklaigqKGvEGEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQCGDkAIAVQCSNGVGRSGTFCAIYSLL
                               || .  . |   .  |||||  |    |.| ..  |.    |     . ..|| ||||.|   .| |..
...............................kg.ddartvaqfhftewPdkdvpkhtssllkfikevkadfGqyth.pliihcsagvgrtgvvisidsvv

ERIKAEQVVDVFQTVKVLRLGRPGAVETLTQYIYCYQMVQ
 . |  ..||||. |  .|  ||  |.|  || . |  | 
ahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 143-336 6.6e-31 102.1 In-house 230-435 (440) alignment 
Range on Protein: 143-336
Range on HMM: 230-435/440.0
DAFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQEDTLTypQYWPSE-GSETYDHLNVRLMSREKQGKLISRKLAIGQKgvEGEHEVVHIQH
. . |.|||| || ||  |. .|| .. .|.| ||.|||.|.. | .   ||| .  | |.  . |     |.  ..  | | .  |  |  ||.  .. 
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndktcs..iywpvntrsvtfgpftvghkgsenmnrvkvrtlelkyk..eevheirqfev

IEWPDKCA--PVNHQ-----SVLDLVSWV-----QLSQQ--QCGDK-AIAVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTVKVLRLGRPGAVETLT
  ||       |. |     .||.|. ..     | | .  . ||   | |.|  |.  || ||..   ||... .  .|||| ...||| ||  | |||
qtwptwiqsdgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvptlt

QYIYCYQMVQ
.|. ||... 
dyllcykllt
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 115-339 9.9e-31 101.6 In-house 34-277 (287) alignment 
Range on Protein: 115-339
Range on HMM: 34-277/287.0
RADYNIKKNRYPSVIPFDGG------------DYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVML-NNLQEDTLTYPQYWPSEGSE-
   ...|||||  |.|.|              ||||| .  .... .||| .|.|.  |. .|| .. . .  .....  ...|  |   .|||      
eelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPm

TYDHLNVRLMS-REKQGKLISRKLAIGQKGVEGEHEVVHIQHIEWPDKCAPVN----HQSVLDLVSWVQLSQQQCGDKAIAVQCSNGVGRSGTFCAIYSL
      | |..   |. .   | | . .   .  . |  .. ..|||| ..       . |||    ..|...  .   . | .. |.||||.. |.. |
rvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvl

LERIKAEQVVDVFQTVKVLRLGRPGAVETLTQYIYCYQMVQRYL
..| .    ||| ..|  ||  | . | .  |. . |. .  | 
vsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyy
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 134-334 1.3e-30 101.3 In-house 36-236 (239) alignment 
Range on Protein: 134-334
Range on HMM: 36-236/239.0
GDYINASFADAF-RKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQEDT-LTYPQYWPSEGSeTYDHLNVRLMSREKQGKLISRKLAIGQKGVE
 ||||||.   .    .|.| ||  .  .  .||.|. | .   ||||  | |       ||||   |  |  | | |   |     | | . . | |  
sdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.kycnlrvtlrktevfadyiirtfvmsqvgqt

GEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQlSQQQCGDKAIAVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTVKVLRLGRPGAVETLTQYIYC
 |. | . .   ||||  |    .|| |   .   .   | .   ..|| ||||.|.|  | ..| . | .. ||.|. || .|  ||  |.|  ||.. 
eeryvyqyhftvwpdkgvpqyatavlglrrkit.kdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfi

YQM
.  
hla
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 134-334 1.3e-30 101.3 In-house 35-235 (239) alignment 
Range on Protein: 134-334
Range on HMM: 35-235/239.0
GDYINASFADAF-RKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQEDT-LTYPQYWPSEGSeTYDHLNVRLMSREKQGKLISRKLAIGQKGVE
 ||||||.   .    .|.| ||  .  .  .||.|. | .   ||||  | |       ||||   |  |  | | |   |     | | . . | |  
sdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.kycnlrvtlrktevfadyiirtfvmsqvgqt

GEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQlSQQQCGDKAIAVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTVKVLRLGRPGAVETLTQYIYC
 |. | . .   ||||  |    .|| |   .   .   | .   ..|| ||||.|.|  | ..| . | .. ||.|. || .|  ||  |.|  ||.. 
eeryvyqyhftvwpdkgvpqyatavlglrrkit.kdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfi

YQM
.  
hla
PTPc_DSPc_SM00012 236-335 2.3e-30 100.3 In-house 2-103 (105) alignment 
Range on Protein: 236-335
Range on HMM: 2-103/105.0
VVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQCG-DKAIAVQCSNGVGRSGTFCAIYSLLERIKAE-QVVDVFQTVKVLRLGRPGAVETLTQYIYCYQ
| |... .|||...| . .|.|.|.  |. ......  | . |.||.||||.|||.|.. ||.....| . ||.||.|| ||  |||.|.|..||...|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

MV
..
al
0051082 (Phosphotyrosine protein) phosphatases II 135-334 8.4e-30 98.7 In-house 4-148 (151) alignment 
Range on Protein: 135-334
Range on HMM: 4-148/151.0
DYINASFADAFrkrnaFILTQAPlghtMAEFWHMICQYKIGTIVMLNNLQEDTlTYPQYWPSEGsetydhlnvrlmsrekqgklisrklaigqkgvegeH
||||.|. . .     ......|    .|.|. .. ...| |||.|....|   ..|.|.|..|                                   .
dyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg.ycpeylpelg...................................i

EVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLsqqqCGDKAIAVQCSNGVGRSGTFCAIYSLLERikaeqvVDVFQTVKVLRLGRPGAVETLTQYIYCYQM
||.||. . |||   |.. ..||.......     .... ..| || |.||.||..|.| .|..      |....... .|| |||.| . .|.......
evlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfa
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 135-339 1e-29 98.5 In-house 68-271 (288) alignment 
Range on Protein: 135-339
Range on HMM: 68-271/288.0
DYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQEDTLTY-PQYWPSEGSETYDHLNV---RLMSREKQGKLISRKLAIGQKGV
 ||.|    . . .. .| .||||  |. |.|.|. .  .  ||||..| |  .    .|.||.  |.     .      .|.   ||..  |   .| .
fyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskeg

EGEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVqlsqqQCGDKAIAVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTVKVLRLGRPGAVETLTQYIY
| .  | ..   ||.|.. | |..| | |.  .     .  .| | |..|.||||.||.  |   || .. .  . . . .. ||  |  |..|  ||.|
eekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqyly

CYQMVQRYL
 ...|  .|
vhrcvleel
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 132-335 3.3e-29 96.8 In-house 27-235 (237) alignment 
Range on Protein: 132-335
Range on HMM: 27-235/237.0
DGGDYINASFADAFRK-RNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQE-DTLTYPQYWPSE-GSETYDHLNVRLMSREKQGKLISRKLAIGQK
 | |||||.. . |    . .| .| ||  .  .|| |. | |   ||||  | | . |   .||||    ..|  | | |  .|.      | | . ..
sgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltvslkkkeefsdytvrslllskr

GVEGEHEVVHI-QHIEWPDKCAPVNHQSVLDLVSWV-QLSQQQCGDKAIAVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTVKVLRLGRPGAVETLT
.   |  ..|  |   |||.  | .  ..| .   . . |.         . || ||||.| |  | ..| . | ..|||... |. .   ||  ..|  
ltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkd

QYIYCYQMV
||.. .| .
qyvfihqti
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 139-330 3e-27 90.1 In-house 80-271 (301) alignment 
Range on Protein: 139-330
Range on HMM: 80-271/301.0
ASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQEDT-LTYPQYWPSEGSETYD--HLNVRLMSREK--QGKLISRKLAIGQKGVE-G
| . ..  . . || ||.||  |. .|| |. ||.. .|||| .  |..     .| |.. ||. |    .... ..|.  . |.. |.| .     .  
anwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfa

EHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSqqqcgDKAIAVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTVKVLRLGRPGAVETLTQyIY
 . |.| |. ||.|.  |  |  . ||.  |. |     .| | |.||.|.||| .| .   |  ...|.. ... ...| ||  |  .| | .| .|
trtvthyqysewtdrgvPkshaelfdlmelvkks.....ekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsq.ly
0044763 (Phosphotyrosine protein) phosphatases II 131-338 7.9e-27 89.4 In-house 15-170 (178) alignment 
Range on Protein: 131-338
Range on HMM: 15-170/178.0
FDGGDYINASFADAFrkrnaFILTQAPLghtmAEFWHMICQYKIGTIVMLNNLQEDT-LTYPQYWPSEGSetydhlnvrlmsrekqgklisrklaigqkg
. ..||||||. . .     ..|...|     |... ......|..||.|.. .|   | ...|||.| .                              
lersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag..............................

vegehevVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQCGdKAIAVQCSNGVGRSGTFCAIYSLLERikaeQVvDVFQTVKVLRLGRPgAVETLTQYI
       .. .|| .|| ..|   . .|..| ...  ....| ....| || |||||||..|.| ....    .. .... .. .|  || .|..  |. 
.......iqylhipipDhgvpdllehflefvefieealdekg.gpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlr

YCYQMVQRY
..|.. .|.
qLyefelrl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 133-342 9.2e-27 88.5 In-house 79-293 (305) alignment 
Range on Protein: 133-342
Range on HMM: 79-293/305.0
GGDYINASFADA-FRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNL-QEDTLTYPQYWPSEGSETYDHLNVRLMSREKQGKLISRKLAI----G
  ||| | .  . .   . || .| || .|. ||| |. | |.  |||| .  .   |   ||||    |  .  .  ..      | . |   |     
psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitll

QKGVEG--EHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQqcgdkAIAVQCSNGVGRSGTFCAIYSLLERIKAE-QVVDVFQTVKVLRLGRPGAVE
.    |  .  | |.|  ||||.  |  . . |.|.| .. |.       | |.|| |.||.||  ||  .||.|  . ..  . . || ||  |  ...
nltysgdqkmsvrhlqwtewpdrgvppckltslellsairgskv.....pivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiq

TLTQYIYCYQMVQRY-LDSF
.  ||.. ....  | |. .
ndvqylfihrvmlnyfleky
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 128-339 5.7e-26 86.2 In-house 59-277 (307) alignment 
Range on Protein: 128-339
Range on HMM: 59-277/307.0
VIPFD--GGDYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQED-TLTYPQYWPSEGSET--Y---------DHLNVRLMSRE
|. ||    ||| | .     | . || .| ||  |. .|| |. | |. ...|| .. |   .   |||| |  ..  .         . | .. .. .
vvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapd

KQGK-LISRKLAIGqkgvEGEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQqqcgdKAIAVQCSNGVGRSGTFCAIYSLLER-IKAEQVVDVFQTV
..   . . |.  .    ..   . |.|  .|||. .|    . ..|.. |.  .       . | || |||||||  ||  . .. |. .   |. . |
edlinvttlkvdwa....qksrtiqhlqwenwpdrgvpqinltainlleavrydt.....npvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklv

KVLRLGRPGAVETLTQYIYCYQMVQRYL
. ||  |. |..|  ||.| ....  |.
eelrsqrhyaiqteaqylylhrvlleyf
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 133-339 1.1e-24 81.8 In-house 58-270 (285) alignment 
Range on Protein: 133-339
Range on HMM: 58-270/285.0
GGDYINASFADAFRK-RNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQEDTLTY-PQYWPSEGSETYDHLNVRLMSREKQGKL----ISRKLAI-
  ||| ||.     | ....| || ||  |...||||| | ||  ..||  | |  .     |.| .  |     .  .   | . .     |   |.. 
drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvi

GQKGVEGE-HEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSqqQCGDKAIAVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTVKVLRLGRPGAVET
  .    |   . |.|   |||. || . . ...|  ||.    .  .| |.|.|| ||||. ||  |     ||  .  ..... |. .|  |  ||..
ntedasseplymnhvqvpwwpdqlapedarpmielykwvkkv..npkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqs

LTQYIYCYQMVQRYL
  |... | ..  |.
hmqflflyvvlmeyf
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 134-339 5.3e-24 79.5 In-house 73-287 (305) alignment 
Range on Protein: 134-339
Range on HMM: 73-287/305.0
GDYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQEDTL-TYPQYWPSEGSETYD------HLNVRLMSRE-------KQGKLI
 .|| | .  .  . . || ||||| .| |.||.|  | |. .| || ||.|       .|..|.  .. .      .. |.. | .        . |. 
heyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvt

SRKLAIGQKGVEgEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQqqcgdKAIAVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVF-QTVKVLRLGR
  .| |   | .  . | |   |.|||.  |   ...|.|.   . |.       |.| || |.||.|.   .  .|... | |...   . .. .|  |
etvlviegpgek.arkvthyhwidwpdrgvpaadlailellekarpsk.....gpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqr

PGAVETLTQYIYCYQMVQRYL
  ...| .||.. .|..  |.
nnsiqtdaqylfvhqvilnyf
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 132-336 3.8e-23 76.8 In-house 57-292 (297) alignment 
Range on Protein: 132-336
Range on HMM: 57-292/297.0
DGGDYINASFADAF--RKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQEDTLT--YPqYWPSEGSE--TYDHLNVRLMSREK--QGKLISRKL
 . ||||| .       .   .||.| ||  |. .||... .  ...|||. .||||     .| ||||   |  .  .. |  .|.      ..|  .|
terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcap.ywpsvvqerlkagdvvveflsstsdefdrviltel

AIGQKgvEGEHEVVHIQHIEWPDKCAP-----VNHQ------------SVLDLVS------WVQLSQQQ---CGDKAIAVQCSNGVGRSGTFCAIYSLLE
 .  .  . .  | |.|.. |||.  |     ..               .| ||       ..||   .     .  . | || ||||||       .|.
qliyr..sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraemprnayllvhcsaGvGrsGvvvlsdvila

RIKAEQVVDVFQTVKVLRLGRPGAVETLTQYIYCYQMVQ
... ... ||   ...||  |.  |.|| |. ..|..| 
klrkkripdvaailsilreqrarlvqtleqfellydavl
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 133-335 4.6e-22 73.0 In-house 65-265 (281) alignment 
Range on Protein: 133-335
Range on HMM: 65-265/281.0
GGDYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQEDT-LTYPQYWPSEG--SETYDHLNVRLMSREKQGKLISRKLAIGQkg
  ||| | .  .   .  .|||| |   | |.||.|| | .  .|||| .. |       .|.| .      .|.| |       .  |.. .| .    
stdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsy..

vEGEH-EVVHIQHIEWPDKCAPVNHQSVLDLVSWVQlsqqqCGDKAIAVQCSNGVGRSGTFCAIYSLLERIKAEQ-VVDVFQTVKVLRL-GRPGAVETLT
 |||   . |    ||||   |   . .| ..  ..     .      ..|| |||||||. |.   |. |..   . |. | |  ||. ||  .|.|| 
.egetrlithwlwkewpdwqvpessevmlkilrkir.....arstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlq

QYIYCYQMV
||.  ....
qymliwkvl
subfamily_egg_pd Subfamily egg 127-338 6.1e-22 72.7 In-house 68-269 (307) alignment 
Range on Protein: 127-338
Range on HMM: 68-269/307.0
SvipfdggDYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQEDtLTYPQYWPSEGSETYDH----LNVRLMSREKQGKLISRK
        |.| |   .     | |||.||||  |. .|| |. | ..  ||||.  .|     . |||   |..       |..  .  ...   . | 
d.......dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes.erceyywpkaesdslvtvpGslrienlkvdskadplfrv

--LAIgqkgVEGEHEVVHIQHIEWpDKCAPVNHQSVLDLVswvQLSQQqcGDKAIAVQCSNGVGRSGTFCAIYS-LLERIKAE-QVVDVFQTVKVLRLGR
  | .    | |..|  ...| .. |     .  | | ..   .. ..    | . ||. .|| ...|. ||   ||. ..       | ..|. ||| |
tklkl....vGgddeerflehwqg.dvnnssdvysplrvl...rklrn..lskpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrr

PGAVETLTQYIYCYQMVQRY
. .||.  .|.. |..|  .
rlsvesvllylfvyrlvlff
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 148-333 1.2e-21 71.8 In-house 4-198 (199) alignment 
Range on Protein: 148-333
Range on HMM: 4-198/199.0
RNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQEDTL-TYPQYWPSEGSET--YDHLNVRLMSREKQ--GKLISRKLAIGQKGVEGEHEVVHIQHI
.  .| || || .|||.|| |. .   | |||.|. | .    || |||.  | |  |  |.|   .   .    . .  |.          |. | |  
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

EWPDKCAPVNHQSVLDLVSWVQLSQ--QQCGDKAIAVQCSNGVGRSGTFCAIYSLLER--IKAEQVVDVFQTVKVLRLGRPGAVETLTQYIYCYQ
 | .| .|     |  .|.  ..|.  .|  |  . |.||.| | .| | |.   .         |||.|.  | ||  | | . .| .| . ||
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_PTPRD_pd Subfamily PTPRD 43-132 1.4e-21 71.8 In-house 263-351 (564) alignment 
Range on Protein: 43-132
Range on HMM: 263-351/564.0
TVQTRDQYAFVHFAVLEALTCGNTEIEAGNLQIAMRKRAAVKPTQNLSGYALEYQRLLaVSSQIEDENSKVGRADYNIKKNRYPSVIPFD
 |||..||.|.| |.||||.|||||.|. ||. ...| | |.. .. .|..||.|||   ...|| |. .|.  . | ||||.. .....
mVqteeQYiFiheailealacgntevesenlkqhlqkLaeveedtemtgleleFqrLa.takeieleefavatkpknkkknrfsnilale
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 149-333 2.1e-21 71.0 In-house 4-197 (198) alignment 
Range on Protein: 149-333
Range on HMM: 4-197/198.0
NAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQEDTL-TYPQYWPSEGSET--YDHLNVRLMSREKQ--GKLISRKLAIGQKGVEGEHEVVHIQHIE
  .| || || .|.|.|| |. .   | |||.|. | .    || |||.  | |  |  |.|   .   .    . .  |.          |. | |   
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDKCAPVNHQSVLDLVSWVQLSQ--QQCGDKAIAVQCSNGVGRSGTFCAIYSLLER--IKAEQVVDVFQTVKVLRLGRPGAVETLTQYIYCYQ
| .| .|     |  .|.  ..|.  .|  |  . |.||.| | .| | |.   .         |||.|.  | ||  | | . .| .| . ||
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
0048076 (Phosphotyrosine protein) phosphatases II 231-338 4.4e-21 70.5 In-house 44-142 (145) alignment 
Range on Protein: 231-338
Range on HMM: 44-142/145.0
EgeHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQcgDKAIAVQCSNGVGRSGTFCAIYSLLErikaEQvVDVFQTVKVLRLGRPGAVETLTQYIY
|  ......... ||| ..|  .. .|... ...  ...  .. ..| || ||||.||..|.| .|.    .. |....... .|  |||||..  |...
e..rlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqrpgavpnpgqlrf

CYQMVQRY
.|. ....
lyefelel
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 134-339 1.5e-20 67.9 In-house 75-285 (302) alignment 
Range on Protein: 134-339
Range on HMM: 75-285/302.0
GDYINASFADAFRKRNAFILTQAPLGHTM---AEFWHMICQYKIGTIVMLNNLQEDTLTYPQYWP--SEGSETYDHL--NVRLMSREKQGKlISRKLAIG
 .|.|||  .    ..  ||.| |   .    .|||.|. | || ..|.|   .| . |  ...|  |.  ..|...  |.|  .. .. |     . . 
dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvl

QKGVEgEHEVVHIQHI-EWPDKCAPVNHQSVLDLVSWVqLSQQQCGDKAIAVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTVKVLRLGRPGAVETL
 .|.  .  .. ....  |..|  ||.  ..   .  |   ... .|. ...   ||.|| |.| .    .|...... . . ..|| .|  || ||..|
Pegcs.nsvlanvyvltnWkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdsl

TQYIYCYQMVQRYL
.||.  | ..  |.
kQyvslyialllyi
0048179 (Phosphotyrosine protein) phosphatases II 197-333 1.7e-20 68.7 In-house 48-139 (144) alignment 
Range on Protein: 197-333
Range on HMM: 48-139/144.0
EgsetydhlnvrlmsrekqgklisrklaigqkgvegeheVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQqcGDKAIAVQCSNGVGRSGTFCAIYSLL
|                                      .....|. ||| ..|   . .|... ...  ..   .. ..| || ||||.||..|.| ..
e......................................giqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk

erikAEQvVDVFQTVKVLRLGRPGAVETLTQYIYCYQ
     .. ........ .|  |||||..  |......
....klg.lsleealalvrsrrpgavpnpgqlrfLle
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 132-345 1.2e-19 65.2 In-house 65-282 (312) alignment 
Range on Protein: 132-345
Range on HMM: 65-282/312.0
DGGDYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQEDTLTYPQYWPSEGSETYDHLNVRLM---------SREKQGKLISRK
|   || | |     | . |. ||.||  | . ||..       .|..|  . ||.      . |.     |  . |.              . |.  | 
denfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrv

LAIGQKGVEGEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQqqcgdKAIAVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTVKVLRLGRPGAV
| .  |    |  . | |   |||.  |   .. | |.| |.  .     | .  .|| ||||.||.. | |..  ..  .  .| ..  .||  |  .|
lkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdk.....kpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsv

ETLTQYIYCYQMVQRYLDSFSDY
... ||.|. . |  .| | . |
rvfpqyvyalrcvleflyskgly
subfamily_ptpA1_pd Subfamily ptpA1 131-298 4.2e-18 60.3 In-house 72-255 (418) alignment 
Range on Protein: 131-298
Range on HMM: 72-255/418.0
FDGGDYINASFADAFRKRnAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQEDT-LTYPQYWPS-----------EGSETYDHLNVRLMS--REKQG
 .| ||||| . |    .  || || ||  |.|.||.|. . .   ||||.   |.  .   .|||            .| | .   .| |.   .. . 
kegsdyinanyidgaypk.qfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdper

KLISRKLAIGQKGVegEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQC---GDK--AIAVQCSNGVGRSGTFCAIYSLLER
..|.|.. .  .|    ... . |.  |||.  |   | . .|.  .   |.|     |.   | |.|| ||||.||||.   ....
eiitrnirltfege..trditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkk
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 134-334 6e-18 59.4 In-house 79-285 (310) alignment 
Range on Protein: 134-334
Range on HMM: 79-285/310.0
GDYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQEDTLTY-PQYWPSEG-SETYDHLNVRLMSREKQGKLISrKLAI------
.||| | .  .   |..|| .| || ||. .|| || | .  .|..| .  |.       |||| | .|||  . |  .|   .   |  .||.      
edyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeic.nlavtfvpdn

---GQKGVE-GEHEVVHIQHIEWPDKCAPVNHQsvlDLVSWVQLSQQQCGdkAIAVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTVKVLRLGRPGA
    ..  .  |  |  |.  .|||.  | ..      |    |.| . |     |.|| |..| .. .|.   .....  . ||. . .  |.  |   
vpvdeqpanlkelrvslikwpnwpdrgvpdekc...htvpqrllaqvrhg..pcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraic

VETLTQYIYCYQM
..|  ||..  ..
iqtelqyliidrv
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 147-338 6.6e-18 59.7 In-house 33-220 (255) alignment 
Range on Protein: 147-338
Range on HMM: 33-220/255.0
KRNAFILtqaplghTMAEFWHMICQYKIGTIVMLNNLQE-DTLTYPQYWPSEGSETYDHLNVRLMSREKQGKLISRKLAIGQKGV--EGEHEVVHIQHIE
..| ..|       |...|...| | |  ..||| ...| .     .|.| |  |     .| . . .   . . | | |  .       |.| | ..  
rknlysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykG

WPDKCAPVNHQSVLDLVSWVQLSqqqcgdKAIAVQCSNGVGRSGTFCAIYSLLE----RIKAEQVV--DVFQTVKVLRLGRPGAVETLTQYIYCYQMVQR
|..| || . . .| ..  |. |      |.. |.||.|.||| .|  . ..       ..  . |  |  . .. ||  |..|..|  |  ..  ||  
WieknaPelareilnilkvvrds......ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvld

Y
.
l
subfamily_hpo-7_pd Subfamily hpo-7 147-336 3.3e-17 57.2 In-house 36-224 (263) alignment 
Range on Protein: 147-336
Range on HMM: 36-224/263.0
KRNAFILtqapLGHTMAEFWHMICQYKIGTIVMLNNLQED-TLTYPQYWPSEGSETYDHLNVRLMSREKQGKLISRKLAIGQKG--VEGEHEVVHIQHIE
..| ..|    |  |...|...| | |  ..||| . .|.      .|.| |  |     || . . . | ... . | . .        |.| | ..  
rknlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykg

WPDKCAPVNHQSVLDLVSWVQLSqqqcgdKAIAVQCSNGVGRSGTFCAIYSLLE----RIKAEQVV--DVFQTVKVLRLGRPGAVETLTQYIYCYQMVQ
|..| .| . ...| ..  .. |      | . | ||.|.|||  |  . ..       ..  . |  |  . .. ||  |..|..|  |  .   || 
Wiekndpelareilnilkvarns......kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvL
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 135-332 4.7e-16 53.8 In-house 47-252 (290) alignment 
Range on Protein: 135-332
Range on HMM: 47-252/290.0
DYINASFAdAFRKRNAFILTQAPLGHT-------MAEFWHMICQYKIGTIVMLNNLQEDTLTY-----PQYWPSEG--SETYDHLNVRLMSREKQGKLIS
||| |..   . .  ..||||.|. ..       . .|| |. | |.  .||| . .| .         .| | .   . ... |.|.  |.||.  .. 
dyiHAnrv.tcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvet

RKLAIGQKGvEGEHEVVHIQHIEWPDKCAPVNHQSVLDLVSWVQlsqqqCGDKAIAVQCSNGVGRSGTFCAIYSLLERIK-AEQVVDVFQTVKVLRLGRP
|.| .   . | |. | | .  .| .  .. .....|.|.. |.     . . .. | | .|. || .. ||      |   .. | . . .|.||  | 
Relvvkfdd.eeeftvtHsllkgWnklnvqedtktllsliqkvk.....asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqra

GAVETLTQYIYCY
 |. . ... .  
laitsalelafvd
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 118-337 1e-15 52.1 In-house 46-277 (303) alignment 
Range on Protein: 118-337
Range on HMM: 46-277/303.0
YNIKKNRYPSVIPFDG-------GDYINASFADAFRKRNAfILTQAPLGHTMAEFWHMICQYKIGTIVM-LNNLQEDTLTYPQYWPSEGS-ETYDHLNVR
 |..|||.  || .|          || ||. .   ...| |||| || || |.|| || . |.  ... | . . |.|     .| .     ...  .|
knmdknrfvdvicldhskvklsdssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersir

LMSrEKQGKLIS-RKLAIGQKGVEGEHEVVHIQHI-EWPDKCAPVN-HQSVLDLVSWVQLSQQQCGDKAIAVQCS-NGVGRSGTFCAIYSLLERIKAEQV
.    |. .|    .| .        .  .|..|  .|| .  | .    ..  .  .|   ..  |   .|  |  |.||.|||. . .    ...|| 
vge.fkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseqa

-VDVFQTVKVLRLGRPGAVETLTQYIYCYQMVQR
 .|. . .. .| ||  ||. |.|. . | ..  
sldlvkclenvrngrlhavqnlsqfsvvytllae
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 156-336 3.9e-15 50.1 In-house 98-285 (302) alignment 
Range on Protein: 156-336
Range on HMM: 98-285/302.0
APLGHTMAEFWHMICQYKIGTIVMLNNLQEDT-LTYPQYWPSEGSE--TYDHLNVRLMSREKQGKLISRK---------LAIGQKGVEGEHEVVHIQHIE
 |   |.  .| .| ||... .| | .. ||    . .|.  .  .  .. .  |. .| ... .  . |         .   .|  . .. |  ...  
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPDKCAPVNHQSVLDLVSWVQLSQqqcgdKAIAVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTVKVLRLGRPGAVETLTQYIYCYQMVQ
|||. || . .. ||.. . .  .     |.. | ||.||||.||. ||   ..  . ..| |. . |. .|  | ||| . .| ||   .| 
wpdhGapkeaytaldilkfcesyk.....knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvt
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 116-253 1.2e-13 45.3 In-house 104-240 (244) alignment 
Range on Protein: 116-253
Range on HMM: 104-240/244.0
ADYNIKKNRYPSVIPFDGGDYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQEDTltypQYWP-SEGSETYD-HLNVRLMSRE
|   .  || |      |  ||||||   . .   .|||| ||  |  .||.|. . ..  .|.|  ..|.     .||| ||  | |.  . | |  |.
aglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed....eywpdseplewyeeditvtltdrd

KQGKLISRKLAIGQKGVEGEHEVVHIQHIEWPDKC-APVNH
.  .. . .| |     |    .  .|  .||    .| .|
efknikasnleiesdmneshqaltmfqisnwpsdgttpndh
subfamily_CG42327_pd Subfamily CG42327 133-260 2.3e-13 44.5 In-house 55-187 (319) alignment 
Range on Protein: 133-260
Range on HMM: 55-187/319.0
GGDYINASFADAFRK-RNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQEDT-LTYPQYWPS----EGSETYDHLNVRLMSREKQGKLISRKLAIG
   |..||.   ... .| .| .|..|. . ..|| .. . .  .|| | .|.|      ..|.|.    .. ..| .. | |  || . . .   | . 
kdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllk

QKGVEGEHEVVHIQHiEWPDKCAPVNHQSVLDLV
.   |   |. |  . .|..   | ...... ..
rvdkeesrelthywy.kwleaevPaeeaaliaml
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 276-332 2.5e-13 44.2 In-house 2-58 (69) alignment 
Range on Protein: 276-332
Range on HMM: 2-58/69.0
AVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTVKVLRLGRPGAVETLTQYIYCY
 |.|| | ||.||| ||   . |||.|..||.|  |. .|  ||  |    .||. .
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifih
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 277-333 8.8e-13 42.4 In-house 2-58 (69) alignment 
Range on Protein: 277-333
Range on HMM: 2-58/69.0
VQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTVKVLRLGRPGAVETLTQYIYCYQ
|.|| | ||.||| ||   . |||.|..||.|  |. .|  ||  |    .|.. ..
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihd
subfamily_eak_pd Subfamily eak 134-252 1e-12 42.1 In-house 78-197 (332) alignment 
Range on Protein: 134-252
Range on HMM: 78-197/332.0
GDYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVML-NNLQEDTLTYPQYWPSEGS--ETYDHLNVRLMSREKQGKLISRKLAIgQKGV
  ||||| |.     . .||| ..    .  || |. . |  .||.| ......   . .|.| ..     . .|.|   .  |...|  |.| . .|| 
lGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrllel.skGn

EgEHEVVHIQHIEWPDKCAPVN
|  |.| | .   | .   |. 
e.thrvlhykvfGwtettlpky
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 133-214 2.9e-12 41.0 In-house 82-167 (350) alignment 
Range on Protein: 133-214
Range on HMM: 82-167/350.0
GGDYINASFADAF----RKRNAF--ILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQEDTLT-YPQYWPSEGsetYDHLNVRLMSREK
. |||||..        .    |  | |||||  |. .|...| . |.  |..|....|  |  . .||.  .   ||  .|.| |. .
tnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqegs...ydditvklaskwe
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 132-248 3.8e-12 40.6 In-house 11-125 (130) alignment 
Range on Protein: 132-248
Range on HMM: 11-125/130.0
DGGDYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQEDTLTYPQYWPSEGSETydHLNVRLMSREKQGKLISRKLAIGQKGVE
.| .||||||     . . ..|||.||  |  .||.|. .  .  .|.|  ..|.   .|.  | |  |.  .. | |  |..  .. . .| | .. .|
qgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeedeywpdsePlewyee..diivtltdrdefknikasnleiesdlne

GEHEVVHIQHIEWPDKC
  . .  .|  .||   
shqaltmfqisnwpsdg
subfamily_CG42327_pd Subfamily CG42327 272-338 5e-11 36.8 In-house 247-314 (319) alignment 
Range on Protein: 272-338
Range on HMM: 247-314/319.0
DKAIAVQCSNGVGRSGTFCAIYSLLERIKAE-QVVDVFQTVKVLRLGRPGAVETLTQYIYCYQMVQRY
   ..| ||.||||.|.  |    .....   . ||. |.|  .| .|  || |  || . |.... |
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
0038934 (Phosphotyrosine protein) phosphatases II 236-338 1.2e-10 36.8 In-house 79-176 (194) alignment 
Range on Protein: 236-338
Range on HMM: 79-176/194.0
VVHIQHIEWPDKCAPVNHQSVLDLVSWVQLSQQQCGDKAIAVQCSNGVGRSGTFCAIYSLL-ERIKAEQVVDVFQTVKvlrlgrPGAVETLTQYIYCYQM
 ... .. .||.... . . .|. ...|.   ... ....|| |  |.||.||..| | .   ...||. .. |. ..      |||...  .. . .. 
gieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekR......pgaipnqdyleallkr

VQRY
.. .
ykel
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 234-338 3.9e-10 34.0 In-house 215-343 (350) alignment 
Range on Protein: 234-338
Range on HMM: 215-343/350.0
HEVVHIQHIEWPDKCAPVNHQSVLDLVS---------WVQLSQQQCGDKAIAVQCSNGVGRSGTFCAIYSLLE-------------RIK-AEQVVD-VFQ
..| ..|   |.|    .| .|.|  .            ..  ..   ..| | || |||| ||.... |||.             ... | .. | ...
yvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisi

TVKVLRLGRPGAVETLTQYIYCYQMVQRY
.|. ||  |   | .|.|.|..|. .. |
ivnelrkqrismvqnldqfifiYeallfy
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 43-99 8.5e-09 29.9 In-house 262-318 (318) alignment 
Range on Protein: 43-99
Range on HMM: 262-318/318.0
TVQTRDQYAFVHFAVLEALTCGNTEIEAGNLQIAMRKRAAVKPTQNLSGYALEYQRL
 |||.||| |.. ..||||..|.||..| .|.  .|.   ..| .  .   .|.|||
mvqtedqyefiydvllealasgdtevdasdlrsrirelreqdpesgttemdaefqrl
subfamily_DSP23_pd Subfamily DSP23 237-331 2.2e-08 28.8 In-house 52-138 (148) alignment 
Range on Protein: 237-331
Range on HMM: 52-138/148.0
VHIQHIEWPDKCAPVNHQsVLDLVSWVQLSQQQcgDKAIAVQCSNGVGRSGTFCAIYSLleriKaEQVVDVFQTVKVLRLGRPGAVETLTQYIYC
. ..... .| . |  .| | ..|  |. ....  ..|..| |  | ||.||. | | .    | |. .   ...  .|  |||.|||. |    
ltlvrlriddyhppaleq.vvefvrvveeaeek..neavsvhcllgrgrtgtmlacylv....k.erklaaaeaiaevrrlrpgsvetveqeklv
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 134-209 3.1e-08 27.3 In-house 90-165 (349) alignment 
Range on Protein: 134-209
Range on HMM: 90-165/349.0
GDYINASFAD--AFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQEDTLTY-PQYWPsEGSetYDHLNVRL
 ||||| .     .   . .| |||||  |. .|...|   ..  .. ||. .| .|    .||  |.|  |.  .|.|
ddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywq.els..ysnitvkl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 43-96 3.5e-08 27.9 In-house 265-318 (319) alignment 
Range on Protein: 43-96
Range on HMM: 265-318/319.0
TVQTRDQYAFVHFAVLEALTCGNTEIEAGNLQIAMRKRAAVKPTQNLSGYALEY
 ||. .|| |.. |.|||...|.||||  .|.  ... |  ..    .| . |.
mvqrpeqYkfiyealleaveagdteievqdlrdrlkqlaekvadtgetgleref
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 128-186 9.3e-08 25.9 In-house 53-113 (332) alignment 
Range on Protein: 128-186
Range on HMM: 53-113/332.0
VIPFDGG-DYINASFADAFRKRNAFILTQAPL-GHTMAEFWHMICQYKIGTIVMLNNLQED
. | ||  |. |||. | . |..|.|..|||.  ||   ||.|. . |   |... ...| 
lapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidek
subfamily_PTPRK_pd Subfamily PTPRK 41-95 1.1e-07 26.0 In-house 257-311 (314) alignment 
Range on Protein: 41-95
Range on HMM: 257-311/314.0
HDTVQTRDQYAFVHFAVLEALTCGNTEIEAGNLQIAMRKRAAVKPTQNLSGYALE
 . |.| .|| |.. ..|||  ||.| | . ... .  .   . |  | |    |
vnmveteeqykfiydvileaclcgetaipvsefkalylesirldpqtnssqlkee
subfamily_PTPDC1_pd Subfamily PTPDC1 239-334 1.7e-07 25.8 In-house 85-171 (182) alignment 
Range on Protein: 239-334
Range on HMM: 85-171/182.0
IQHIEWPDKCAPvNHQSVLDLVSWVQLSqqqCGDKAIAVQCSNGVGRSGTFCAIYSLL-ERIKAEqvvdvfQTVKVLRLGRPGAVETLTQYIYCYQM
.  . |.|  ..   ...||.|  |. .   . ....|| |  | || |   | | .  .|..||      ...|..|  || ...| .|   . . 
vynfgwkDygva.sleriLdivkvvafa...lqegkvavhChaGlGrtGvliacylvyakrltae......kaiklvrskrpksiqtreqvelvkef
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 42-68 1.8e-07 25.7 In-house 271-297 (298) alignment 
Range on Protein: 42-68
Range on HMM: 271-297/298.0
DTVQTRDQYAFVHFAVLEALTCGNTEI
 .|||..||.|.. ||||||...|.||
gavqteeqYvfiyeavlealdsfndei
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 233-338 2.1e-07 24.6 In-house 217-343 (349) alignment 
Range on Protein: 233-338
Range on HMM: 217-343/349.0
EHEVVHIQHIEWPDKCAPVNHQSVLDLVS---------WVQLSQQQCGDKAIAVQCSNGVGRSGTFCAIYSLLE----------RIKA--EQVVDVFQTV
 .|.. .|  .|.|    .| .|.|  .          . .|  ..    .. | || | ||.|... . .||.          .||    .   .. .|
PyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiiv

KVLRLGRPGAVETLTQYIYCYQMVQRY
  ||  |   |. |.|.| .|. . .|
nelrkqrismvqnlaqfiaiyealLky
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 231-339 2.5e-07 23.6 In-house 199-309 (346) alignment 
Range on Protein: 231-339
Range on HMM: 199-309/346.0
EGEHEVVHI---QHIEWPDKCAPVNHQSVLDLVSWvQLSQQQCGDKAIAVQCSNGVGRSGTFCAIYSLLERIKAEQVVDVFQTVKVLRLGRPGAVETLTQ
||. . |     .|  |     | .   .. ..    ||..|  .  . |    | ||. .|      ....      .... .| ..  |||.||...|
egnsdsvicqvhhhapwkhlqqppktlpiikmihq.flsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaq

YIYCYQMVQRYL
|   | .|  |.
yasiyaivfdyi
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 134-186 3.1e-07 24.2 In-house 70-122 (347) alignment 
Range on Protein: 134-186
Range on HMM: 70-122/347.0
GDYINASFADAFRKRNAFILTQAPLGHTMAEFWHMICQYKIGTIVMLNNLQED
  |||||       .. .|||| || .|. .||.|.   |.  .| . . ..|
etyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikd
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 42-131 4.7e-07 23.3 In-house 257-346 (515) alignment 
Range on Protein: 42-131
Range on HMM: 257-346/515.0
DTVQTRDQYAFVHFAVLEALTCGNTEIEAGNLQIAMRKRAAVKPTQNLSGYALEYQRLLAVSSQIEDENSKVGRADYNIKKNRYPSVIPF
  |||..||||.. |||| |   || |    .   ..   .    .  |  . |.| | ..  .    ... ||.  |  |||| . .|.
ylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmtkefqtlkslcpdppasqtrsgrtrdnhpknrygnnlpl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 43-79 7.1e-07 23.7 In-house 265-301 (305) alignment 
Range on Protein: 43-79
Range on HMM: 265-301/305.0
TVQTRDQYAFVHFAVLEALTCGNTEIEAGNLQIAMRK
 ||| ||| |.| |. | .|||.|.|   ||.... |
mvqtldqYvflhdaldelitcgdtsiigsnlrarvnk
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 41-74 1.7e-06 22.2 In-house 246-279 (283) alignment 
Range on Protein: 41-74
Range on HMM: 246-279/283.0
HDTVQTRDQYAFVHFAVLEALTCGNTEIEAGNLQ
   |||.||| .|| .|||   ||.|.| | .||
mmavqtldqyklvhelvleqalcgdtqiaavdlq
subfamily_CDC14_pd Subfamily CDC14 272-332 6.5e-06 20.2 In-house 263-317 (328) alignment 
Range on Protein: 272-332
Range on HMM: 263-317/328.0
DKAIAVQCSNGVGRSGTFCAIYSLlERIKaeqvVDVFQTVKVLRLGRPGAVETLTQyIYCY
. |||| |  |.|| ||. | | . .. .    .   ...  ||. ||| | .  |  ...
eGaiavhCkaGLGrtGtLiacylm.khyr....ftaaeaiawlricrPGsvigpqq.kfle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 41-77 8.3e-06 19.4 In-house 174-210 (440) alignment 
Range on Protein: 41-77
Range on HMM: 174-210/440.0
HDTVQTRDQYAFVHFAVLEALTCGNTEIEAGNLQIAM
 . ||| .|||||| ||||.| ||.| |   ..   .
pqmvqtpeqyafvheavlegllcgdtliledditerv