Gene NvecPTP-sf2-11 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily NvecPTP-sf2
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP054_AA protein Get Run
NvecP054_AA_2-112 phosphatase_domain Get Run
NvecP054_AA_124-413 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 114-419 5.8e-118 388.5 In-house 1-297 (298) alignment 
Range on Protein: 114-419
Range on HMM: 1-297/298.0
GNTQILAHDLRITLSRMEDVDKELKMTRFDSEFKTLNKVSPILPKACYIVASYPENKDKNRYSDILASDFSRVVLTAIDDNEITTYINAVHISGYKQQHA
|||.| |.||...|.....|.|. |.|....||..||.||  ...... ||..||||.||||.||.|.|.|||||...|..|...||||.....||...|
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

FIVTQYPLTATVSDFWRMLSEQDSACVVLFQPTEEG---DFPQFWPEVGKETYDMISVecsdersssvdNLRASYDQSEIAQLRFNVKDLRTPeNLHKIK
||.||.|||.||.|||||..|.|....|.....||    .....||..|||||..|.|           .|........... ...|.. ..  . ....
fiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitv...........sllskeefadlivrklkvskkkee.kerevr

MFVVSGWTSEDETPPTSSIITLIAKVERWQQQSGNGPITVVCSDGIGRSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQE
.. .. |......  ..|...|..||...|||.|| |..| ||.|.||||||.|..|||||||.|||.||.|..|..|. |||.|.|...|.||..||.|
qlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavle

YLAAFDDYA
.|..|.|..
aldsfndei
subfamily_PTPRD_pd Subfamily PTPRD 163-418 9.2e-72 237.4 In-house 42-287 (564) alignment 
Range on Protein: 163-418
Range on HMM: 42-287/564.0
VASYPENKDKNRYSDILASDFSRVVLTAIDDNEITTYINAVHISGYKQQHAFIVTQYPLTATVSDFWRMLSEQDSACVVLFQPTEEGD---FPQFWPEVG
.|..|.|| ||||..|.| | |||||.... .| . |||| .| ||....|.| || ||  |..|||||. ||.|...|.   .|| .   . ..||| |
aankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg

KETYDMISVECSDERSSSvdnlrasydqsEIAQLRFNVkDLRTPENLHKIKMFVVSGWTSEDETPPTSSIITLIAKVERWQqQSGNGPITVVCSDGIGRS
.|||. . |. ..|   .           ..    |..    . .. .... |    | ...    . |...|| ||.... ....|||.| || |.||.
tetygeltVtleeeeela...........dyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRT

GTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYLAAFDDY
||| .. ..|||.| |...|. | .||.|  |. .|.|   | |||.|..|.||.... 
GtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnte
0050432 (Phosphotyrosine protein) phosphatases II 110-418 1.5e-69 230.1 In-house 11-305 (308) alignment 
Range on Protein: 110-418
Range on HMM: 11-305/308.0
AIQCGNTQILAHDLRITLSRMED-VDKELKMTRFDSEFKTLNKVSPilpKACYIVASYPENKDKNRYSDILASDFSRVVLtaiddNEITTYINAVHISGY
.. ...|.||...|....  .   ..| | ..... ||..|..| |      | ||. |||||||||.|||. | |||.|     .| ..|||| ...||
lllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkp...lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgy

--KQQHAFIVTQYPLTATVSDFWRMLSEQDSACVVLFQPTEEGD---FPQFWPEV---GKETYDMISVECSDERSssvdnlrasydQSEIAQLRFNVKDL
  |....||.||.||  || |||||. ||.. ..| .  ..| .   ..|.||.    | ..|....|.. .| .           .... .  . ...|
ssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev...........lddytvrtleltnl

RTPENlHKIKMFVVSGWTsEDETPP-TSSIITLIAKVERWQqqsGNGPITVVCSDGIGRSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTA
...|  .... |   .|  .. .|| ........ .|....   ..||| | ||.|.||.||| ||. .||... |. .||..|.| .|  ||| | |  
gdges.rtvthfhytnWp.dhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpe

EYKFIHYAVQEYLAAFDDY
 |.|...|..|||  .  .
qylflyralleylklkltk
subfamily_PTPRD_pd Subfamily PTPRD 3-155 2.9e-69 229.2 In-house 173-325 (564) alignment 
Range on Protein: 3-155
Range on HMM: 173-325/564.0
EKEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNPPDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYTF
..| |||.||||| ||||||||..|..|...|.|||.|.|||||...||||||||.||||||||||.|...|  .||..||. ||. | ||||||||| |
ssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiF

CHDAVLEAIQCGNTQILAHDLRITLSRMEDVDKELKMTRFDSEFKTLNKVSPI
.|.|.|||..||||.. ...|. .|.... |... .|| .. ||. |.  ..|
iheailealacgntevesenlkqhlqkLaeveedtemtgleleFqrLatakei
0051299 (Phosphotyrosine protein) phosphatases II 137-412 2e-68 226.3 In-house 20-286 (288) alignment 
Range on Protein: 137-412
Range on HMM: 20-286/288.0
LKMTRFDSEFKTLNKVSPIlpkACYIVASYPENKDKNRYSDILASDFSRVVLTAIDDNEITTYINAVHISGYKQQHAFIVTQYPLTATVSDFWRMLSEQD
  .|..  ||..| .. |      . .|..|||..||||||||. | |||.|. .|..| ..|||| .|.||.....||.||.||  ||.|||||. ||.
ngltglleefeellsllpd...ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqn

SACVVLFQPTEEGD---FPQFWPEVGKETYDMISVECSDERSssvdnlrasydQSEIAQLRFNVKDLR---TPENLHKIKMFVVSGWTsEDETPP-TSSI
. ..| . ...| .   ..|.||. |..||. |.|.. .| .           .... .  . |..|.    ... .... | . .|  .. .|. ....
vrvIvmltklvelgrekcaqYwplggsltygditvtllseev...........lddytvrtlevtnldlldgdgesrtvthfhytnwp.dhgvpdspell

ITLIAKVERWQQqSGNGPITVVCSDGIGRSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYL
.... .| .... ||.||. | ||.|.||.||| ||. .||... |...|||.|.| .|  |||.| |   |.|...|. |||
ldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0046845 (Phosphotyrosine protein) phosphatases II 142-419 7.1e-67 221.1 In-house 2-281 (284) alignment 
Range on Protein: 142-419
Range on HMM: 2-281/284.0
FDSEFKTLNKVSPILPkACYIVASYPENKDKNRYSDILASDFSRVVLTAIDDN-EITTYINAVHISGY-----KQQHAFIVTQYPLTATVSDFWRMLSEQ
.. ||..|... . |    . || .|||..||||.|||. | |||.|. .|.. | ..|||| ...||     .....||.||.||  || |||||. ||
leeefeellsltvkll.lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

DSACVVLFQPTEEGD---FPQFWPEVG-KETYDMISVECSDERSssvdnlrasydQSEIAQLRFNVKDLRTPENLHKIKMFVVSGWTsEDETPP-TSSII
.. ..| . ...| .   ..|.||. | . ||. ..|.. .|             .. . . .. ...| .... .... | . .|  .. .|| .....
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseev...........kddytvrtleltnlgytgesrtvthfhytswp.dhgvppspedll

TLIAKVERWQQQ-SGNGPITVVCSDGIGRSGTFSALYSVLERVKIEQ---VIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYLAAFDDYA
... .|...... .|.||| | ||.|.||.||| ||. .||... |.   ..|||.|.| .|  ||| | | . |.|...|..|||  .  ..
eflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltll
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 138-416 2.3e-66 219.0 In-house 21-287 (319) alignment 
Range on Protein: 138-416
Range on HMM: 21-287/319.0
KMTRFDSEFKTLNKVSPIlpkaCYIVASYPENKDKNRYSDILASDFSRVVLTAIDDNEITTYINAVHISGYKQQHAFIVTQYPLTATVSDFWRMLSEQDS
 .| .. |||.|.. ..      .  || .|||.||||..||| | .||||...|. | ..|||| .| ||.....|| || ||  |..|||||. |..|
getllekefkllkeavnd....tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeees

ACVVLFQPTEE-G--DFPQFWPEVGKETYDMISVECSDERSSsvdnlrASYdqsEIAQLRFNVKD--LRTpenlHKIKMFVVSGWTSEDETPPTSSIITL
 .||.     | .   . ..|||   |.|  . |.  .|.        . |   .| .| .| |   . |     ..| |    |. .|    . |.. |
sivvmltklveklkvklkkywpeenfeeyGrlivtleeeeel......edy...iirklklnkkssevet....RevkhfqyteWpdhdvPekatslldl

IAKVERWQQQSGNGPITVVCSDGIGRSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYLAAFD
. .... .... .|||.| ||.|.|| ||| .|  .||||| |.|.|| . .. .|. |. .|.. . ||||..|. |.. |.|
lkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd
0040438 (Phosphotyrosine protein) phosphatases II 138-413 6.9e-65 214.7 In-house 16-277 (317) alignment 
Range on Protein: 138-413
Range on HMM: 16-277/317.0
KMTRFDSEFKTLNKVSPIlpkaCYIVASYPENKDKNRYSDILASDFSRVVLTAIDDNEITTYINAVHISGYKQQHAFIVTQYPLTATVSDFWRMLSEQDS
 .|.. .||..| ....      | ||..|||||||||.|||  |.|||.|. ..  . ..|||| ...|......||.||.||  || |||||. ||..
dftalleefedllslkld....tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgv

ACVVLFQPTEEGD---FPQFWPEVGKETYDMISVECSDERSssvdnlrasydQSEIAQLRFNVKDLrTPENLHKIKMFVVSGWTsEDETP-PTSSIITLI
 ..| . ..|| .   . |.||. .. ||. ..|.. .|              ..|  ... |.||   .. .... |   ||. .. .|  ..... ..
tvivmLteleelgrekcaqYwplgetltygdftvtllseee...........lagitlrtlevedl.gdsesrtvthfhytgWp.dhgvppspdllldfl

AKVERWQQqSGNGPITVVCSDGIGRSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYLA
 .|..... ...||. | ||.|.||.||| |.| .||... |. .|| .|.| .|  ||| | | . |.|...|..||| 
eavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylk
0039614 (Phosphotyrosine protein) phosphatases II 134-415 1.9e-64 213.3 In-house 26-292 (297) alignment 
Range on Protein: 134-415
Range on HMM: 26-292/297.0
DKELKMTRFDSEFKTLNKVSPilPkacYIVASYPENKDKNRYSDILASDFSRVVLTAIDDN-EITTYINAVHISGYKQ-QHAFIVTQYPLTATVSDFWRM
.| ...|... ||..| .. |  .   | .|  |||||||||.|||. |.|||.|. .|.  . ..|||| ...||.. ...||.||.||. || |||||
ekansktllllefeellslkp..d...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrm

LSEQDSACVVLFQPTEEGD--FPQFWPEVGKeTYDMISVECSDERSssvdnlrasydQSEIAQLRFNVKDlrTPENlHKIKMFVVSGWTsEDETP-PTSS
. ||.. ..|   ...| .  ..|.||| |  ||. ..|.. ..              . . .  ..|..  . |  .....| . ||  .. .|  ...
vweqgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkveh...........ldgytvrtlevtn..nges.rtvthfqytgwp.dhgvppslel

IITLIAKVERWQQQS-GNGPITVVCSDGIGRSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYLAAF
.. .. .|....... ..||. | ||.|.||.||| |.| .||... |. .|||.|.| .|  ||| | |   |.|...|..|.|  .
lleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
0036941 (Phosphotyrosine protein) phosphatases II 136-415 2.4e-64 212.8 In-house 9-280 (297) alignment 
Range on Protein: 136-415
Range on HMM: 9-280/297.0
ELKMTRFDSEFKTLNKVSPILPkacYIVASYPENKDKNRYSDILASDFSRVVLtaidDNEITTYINAVHISGYKQQHAFIVTQYPLTATVSDFWRMLSEQ
 | .... .||..| .. .. .   . ||..|||..||||.|||. |..||.|    |.| . |||| ...||.....||.||.||  || |||||. ||
llflalllkefeellpllllgs...lsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweq

DSACVVLFQPTEEGDF---PQFWPEV--GKETYDMISVECSDERSSsvdnlrasyDQSEIAQLRFNVKDLRTPeNLHKIKMFVVSGWTSEDETPPTSSII
.. ..| . . .| ..   .|.||.   .  ||. ..|.. .. .          . ... .  . |.|.... . .....| . ||   .  . ..|..
nvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevv.........llddytlrtlevtdtgng.esrtvthfhytgwpdhgvpespasll

TLIAKVERWQQQS-GNGPITVVCSDGIGRSGTFSALYSVLERVK---IEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYLAAF
 .| .|....... ..||. | ||.|.|||||| |.. .|....   .|. .|.|.|.| .|  ||| | |   |.|...|..|.|  .
dfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk
0047943 (Phosphotyrosine protein) phosphatases II 134-412 4.1e-64 212.0 In-house 6-272 (273) alignment 
Range on Protein: 134-412
Range on HMM: 6-272/273.0
DKELKMTRFDSEFKTLNKVSPilpKACYIVASYPENKDKNRYSDILASDFSRVVLtaidDNEITTYINAVHISGYKQQHAFIVTQYPLTATVSDFWRMLS
.| | .|..  ||..| .. |      | ||..|||||||||.|||. | |||.|    ... . |||| ...||.....||.||.||  || |||||. 
ekllgltllleefelllslkp...lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvw

EQDSACVVLFQPTEEG---DFPQFWPEVG---KETYDMISVECSDERSssvdnlrasydQSEIAQLRFNVKDLRTPEnLHKIKMFVVSGWTsEDETP-PT
||.. ..|   ...|    ...|.||. |   ..||. ..|.. .| .            . . .  . ...| |.|  .... | . ||  .. .|  .
eqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet...........kddytvrtleltnlgtge.srtvthfhytgwp.dhgvppsl

SSIITLIAKVERWQQQS-GNGPITVVCSDGIGRSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYL
.|....| .|....... .|||. | ||.|.||.||| ||. .|.... |. .|||.|.| .|  ||| | |   |.|...|. |||
esllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 164-420 6e-64 211.1 In-house 41-288 (318) alignment 
Range on Protein: 164-420
Range on HMM: 41-288/318.0
ASYPENKDKNRYSDILASDFSRVVLTAIDDNEITTYINAVHISGYKQQHAFIVTQYPLTATVSDFWRMLSEQDSACVVLFQP-TEEG--DFPQFWPEVGK
.  | || |||| .||| | .|| |. ....| . |||| .| ||....|.| .| ||. |..|||||. ||.|| .|..   .|.|     ..||. | 
slepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgs

ETYDMISVECSDERSSSVDNLRasydqseiaqlRFNVKDlRTPENLHKIKMFVVSGWTSEDETPPTSSIITLIAKVERWQQQSGNGPITVVCSDGIGRSG
..|. . || ..| ..|   ||           .|.|.  .  |.  ... . .  |. |.    ..|.. |. .|...||.||.|||.| || |.|| |
rsygklvvelkeevelsdyvlr...........efkvtr.teeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtG

TFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYLAAFDDYAN
.| |. ..|||.| |...||.| .| .|  |. .|.|   |.||. ...|.||..| ...
vfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevd
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 163-420 1.1e-63 209.8 In-house 3-250 (250) alignment 
Range on Protein: 163-420
Range on HMM: 3-250/250.0
VASYPENKDKNRYSDILASDFSRVVLTAIDDNEITTYINAVHISGYKQQHAFIVTQYPLTATVSDFWRMLSEQDSACVVLFQPTEEGD--FPQFWPEVGK
||  |.||.||||.||.| | |||||   . .... ||||... ||....|||.|| ||.||. |||||. |..|. .|...  .| .  ..|.||  . 
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPveka

ETYDMISVECSDErsssvdNLRASYDQSeiaqlRFNVKDLRTPENlHKIKMFVVSGWTSEDETPPTSSIITLIAKVERWQQQSGNGPITVVCSDGIGRSG
|.|  . |.  ..      .  | | .      .. .   .  ..   .. .    |        . ... |. ||.. |||.||.|. | || |.||||
ekyGdvtvsllsk......eefadytkr.....klklskakkade.rivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsG

TFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYLAAFDDYAN
.| |...||||.|.|.|.|| . ||..|. ||. |.. . | |.. .....| ...|||.
afiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedyar
0043336 (Phosphotyrosine protein) phosphatases II 139-412 1.2e-62 207.2 In-house 19-277 (278) alignment 
Range on Protein: 139-412
Range on HMM: 19-277/278.0
MTRFDSEFKTLNKVSPilpkACYIVASYPENKDKNRYSDILASDFSRVVLTAIDDNEITTYINAVHISGYKQQHAFIVTQYPLTATVSDFWRMLSEQDSA
 |..  ||..|... .      | .| .|||||||||.|||. |.|||.|. ..  . ..|||| ...||.....||.||.||. || |||||. |... 
ktllllefeellsfkl....dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvt

CVVLFQPTEEGD---FPQFWPeVGKETYDMISVECSDERSssvdnlrasydQSEIAQLRFNVKDLRTPENlHKIKMFVVSGWTsEDETP-PTSSIITLIA
..|   . .| .   . |.||  | .||. ..|.. .| .           .. . .  ..|..|...|  ...  .   ||  ....| ..|... .. 
tivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeeh...........lddytvrtlevtnlgdges.rtvthyhylgwp.dhgvpeslsllldflk

KVERWQQqSGNGPITVVCSDGIGRSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYL
.| .... . |||. | ||.|.||.||| ||| .||... |. .|...|.| .|  ||| | |   |.|...|..|||
avreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
0045450 (Phosphotyrosine protein) phosphatases II 138-412 2.1e-62 207.0 In-house 25-304 (307) alignment 
Range on Protein: 138-412
Range on HMM: 25-304/307.0
KMTRFDSEFKTLNKVSPILpKACYIVASYPENKDKNRYSDILASDFSRVVLTAIDDN-EITTYINAVHI--------SGYKQQHAFIVTQYPLTATVSDF
 .|..  ||..|..| ..|    | .|..|||||||||.|||. | .||.|. .|.. | . |||| ..        .||.....||.||.||  || ||
fltgllkefekllsvtvfl.lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedF

WRMLSEQDSACVVLFQPTEEGDFP---QFWPEVGKE-TYDMISVECSDERSssvdnlrasydQSEIAQLRFNVKDLRTPENLHKIKMFVVSGWTSEDETP
|||| ||.. ..|   ...| ...   |.||. | | ||. . |.. .|             ....  ....|.||.  .. .... |   ||   .  |
wrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh...........ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpp

PTSSIITLIAKVERWQQQS-GNGPITVVCSDGIGRSGTFSALYSVLERVKIEQV---IDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYL
 ..... .| .|....... ..||. | ||.|.||.||| |.| .|.... |..   .|.|.|.| .|  ||| | .   |.|...|..|.|
sfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
DSPc_SM00195 163-412 4.7e-62 205.0 In-house 20-262 (263) alignment 
Range on Protein: 163-412
Range on HMM: 20-262/263.0
VASYPENKDKNRYSDILASDFSRVVLTAIDDNEITTYINAVHISGYKQQHAFIVTQYPLTATVSDFWRMLSEQDSACVVLFQPTEE---GDFPQFWPEV-
 |  ..||.||||..||  | .|| |. ....| ..|||| .|.|.......|.||.||  ||.||||| .|... ..| .   ||       ..|||  
eaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpees

-GKETYDMISVECSDERSSSvdnlrasydqSEIAQLRFNVKDLRTpENLHKIKMFVVSGWTSEdETP-PTSSIITLIAKVERWQQQSgNGPITVVCSDGI
 ||||.. |||.. .. . .          .|| .  ....   . |. .|.. . . .|. . ..|  |.|.. |. .|. ....| .||| |.||.|.
ggketfgkisvklvevekkk..........deiilrtleltkegk.eetrkvtqyqyknWpdh.gvpdstksvlellravkksksts.sgpivVhCsaGv

GRSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYL
||.||| .. ..|.... |. .|. . .|..|  |||.|.| ..|.||. |. ||.
gRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 163-412 4.7e-62 205.0 In-house 20-262 (263) alignment 
Range on Protein: 163-412
Range on HMM: 20-262/263.0
VASYPENKDKNRYSDILASDFSRVVLTAIDDNEITTYINAVHISGYKQQHAFIVTQYPLTATVSDFWRMLSEQDSACVVLFQPTEE---GDFPQFWPEV-
 |  ..||.||||..||  | .|| |. ....| ..|||| .|.|.......|.||.||  ||.||||| .|... ..| .   ||       ..|||  
eaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpees

-GKETYDMISVECSDERSSSvdnlrasydqSEIAQLRFNVKDLRTpENLHKIKMFVVSGWTSEdETP-PTSSIITLIAKVERWQQQSgNGPITVVCSDGI
 ||||.. |||.. .. . .          .|| .  ....   . |. .|.. . . .|. . ..|  |.|.. |. .|. ....| .||| |.||.|.
ggketfgkisvklvevekkk..........deiilrtleltkegk.eetrkvtqyqyknWpdh.gvpdstksvlellravkksksts.sgpivVhCsaGv

GRSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYL
||.||| .. ..|.... |. .|. . .|..|  |||.|.| ..|.||. |. ||.
gRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPRA_pd Subfamily PTPRA 141-412 2.1e-61 202.6 In-house 33-295 (330) alignment 
Range on Protein: 141-412
Range on HMM: 33-295/330.0
RFDSEFKTLNKvSPIlpKACYIVASYPENKDKNRYSDILASDFSRVVLTAIDDNEITTYINAVHISGYKQQHAFIVTQYPLTATVSDFWRMLSEQDSACV
.|  ||..|   .||  .| . .||  |||.|||. .||  |||||.|. .. .| . |||| .| |||... || .| |.. || |||||. ||.|| .
lfreefnalPa.gpi..qatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksati

VLFQPTE---EGDFPQFWPEVGKETYDMISVECSDERSSSVDNLRASYdqseIAqlrfNVKDLRTPENLHKIKMFVVSGWTSEDETPPTSSIITLIAKVE
|..   .   |    |.||. |  ||  | ||  ||  .    .|       .     .. | .  ..   .. |   .|        .  .. |..||.
vmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkfl....vq....qlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvk

RWQQQSGNgPITVVCSDGIGRSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYL
. .|||.. ||.| || |.||.||| .| .|||||| |...|| ...| .|  || .|.|   |.||. ...|| 
klnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 135-418 4.2e-61 201.4 In-house 15-289 (290) alignment 
Range on Protein: 135-418
Range on HMM: 15-289/290.0
KELKMTRFDSEFKTLNKVSpilPKACYIVASYPENKDKNRYSDILASDFSRVVLTAIDDNEI--TTYINAVHISGYKQQHAFIVTQYPLTATVSDFWRML
.   ...| ..||.|.. .    .    |.  ..|| .||...|. .|  |..|  | ...     ||||..| |||.....|.|| |.. |. |||...
hakgnegfrnqfkmldsge...sehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkli

SEQDSACVVLFQP-TEEGD--FPQFWPEVGKETYDMISVECsdersssvdnlRASYDQSEIAQLRFNVKDLRTPENLHKIKMFVVSGWTSEDETPPTSSI
 .......|.    .|||     |.||. . ..|. .|..                  .|. . ...||. .. .. .... . .. | |... . ...|
wqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikl...........lneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqti

ITLIAKVERWQQQSGNGPITVVCSDGIGRSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYLAAFDDY
...|..... | ..||..| | |||..|||..| |..  ....|.|.||||.| .| .|| .||.|.|. .|..|.. | .||  |. |
llvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety
subfamily_Ptp69D_pd Subfamily Ptp69D 141-413 3e-58 192.4 In-house 23-287 (307) alignment 
Range on Protein: 141-413
Range on HMM: 23-287/307.0
RFDSEFKTLNKVspILPKACYiVASYPENKDKNRYSDILASDFSRVVLTAIDDNEITTYINAVHISGYKQQHAFIVTQYPLTATVSDFWRMLSEQDSACV
 .  |...|..     .| .  |.   ||. |||| || | |  ||.|. |  .| ..|||| .| |||... ||. | |. ||. |||||..||..  .
glakeyekLear..eidkstk.vsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtli

VLFQPTEEGDF---PQFWPEVGKETYDMISVECSDERSSSvDNLRASYDQSEIAQLRFNVkdlrtpENLHKIKMFVVSGWTsEDETPP-TSSIITLIAKV
|.    .| .    ...||.  .  |. | |.. .|.. | |  . ..| |.. .   .|      |. .|.  .   ||  . . |  . ... || .|
vmlsnlteknrkkcakYWpiedevqygdilvklvseekhs.dyiiReldvskkkeesgev......edsrkvvqyhytgWk.DskvPevargllklieqv

ERWQQQSgNGPITVVCSDGIGRSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYLA
.  .... ..||.| || | ||||.| || |.|...| |. .|. . .| .|  |. ||.  . |.|.. |. .|  
relykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
0040439 (Phosphotyrosine protein) phosphatases II 162-412 3.3e-58 192.5 In-house 4-246 (249) alignment 
Range on Protein: 162-412
Range on HMM: 4-246/249.0
IVASYPENKDKNRYSDILASDFSRVVLTAIDDNEITTYINAVHISGYKQQHAFIVTQYPLTATVSDFWRMLSEQDSACVVLFQPTEEG---DFPQFWPEV
 ||..|||||||||.|||. |.|||.|. ... . . |||| .|.||.....||.||.||. ||.|||||| |... ..| . ...|    .. |.||. 
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplg

GKETYDMISVECSDERSssvdnlrasydQSEIAQLRFNVKDLrTPENLHKIKMFVVSGWTSEDETPPTSSIITLIAKVERWQQQS-GNGPITVVCSDGIG
|  .|....|.. .. .            ... .  . ...|    . .... . . .|   .  | ..... .| .|. ....   .||. | ||.|.|
gsleygdftvtllsvev...........kddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvg

RSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYL
|.||| |.| .||... |. .|...|.| .|  ||| | .   |.|...|..|.|
RtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0042113 (Phosphotyrosine protein) phosphatases II 164-412 3.1e-57 189.1 In-house 4-243 (245) alignment 
Range on Protein: 164-412
Range on HMM: 4-243/245.0
ASYPENKDKNRYSDILASDFSRVVLTAIDDNEITTYINAVHISGYKQQHAFIVTQYPLTATVSDFWRMLSEQDSACVVLFQPTEEGD---FPQFWPEVGK
|..|||||||||||||. |..||.|. .. .. ..|||| ...||.. . ||.||.||. || |||||| |... ..| . ..|| .   ..|.||. ..
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplges

ETYDMISVECSDERSssvdnlrasydQSEIAQLRFNVKDLRTPEnLHKIKMFVVSGWTsEDETPP-TSSIITLIAKVERWQQQSGNGPITVVCSDGIGRS
 ||. ..|.. .| .            ... .  ..|..|...|  ...  .   .|  .. .|. ..... ..  |........|||. | ||.|.||.
ltygdftvtllseeh...........lddytvrtlevtnlgdde.srevihyhylpwp.dhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRt

GTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYL
||| |.| .||... |. ... .|.| .|  ||| | |   |.|...|..|.|
GtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
Y_phosphatase Protein-tyrosine phosphatase 169-410 3.3e-56 185.7 Pfam-A 1-235 (235) alignment 
Range on Protein: 169-410
Range on HMM: 1-235/235.0
NKDKNRYSDILASDFSRVVLTAIDDN-EittYINAVHISGYKQQHAFIVTQYPLTATVSDFWRMLSEQDSACVVLFQPTEEG---DFPQFWP--EVGKET
||.||||.|||. |..|| |.  ... .   |||| ...|||....||.|| ||  |..|||||. .... ..|.    ||     ..|.||  | ...|
nkkknRykdilpydktrvklkgsegpsd...YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YDMISVECSdersssvdnLRASYDQSEIAQLRFNVKDLRTPENLHKIKMFVVSGWTSEDETPPTSSIITLIAKVERWQqQSGNGPITVVCSDGIGRSGTF
|. |.||.           . . |..|..   ...|.  .... ...|.. . .|. ..    ..|.. || |||... .. .||..|.||.|.||.|||
ygdikvelk.........ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtf

SALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQE
 ||  .||... |. .||||..| .|  |||.|.. ..|.|.. |..|
valdilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 169-410 3.3e-56 185.7 In-house 1-235 (235) alignment 
Range on Protein: 169-410
Range on HMM: 1-235/235.0
NKDKNRYSDILASDFSRVVLTAIDDN-EittYINAVHISGYKQQHAFIVTQYPLTATVSDFWRMLSEQDSACVVLFQPTEEG---DFPQFWP--EVGKET
||.||||.|||. |..|| |.  ... .   |||| ...|||....||.|| ||  |..|||||. .... ..|.    ||     ..|.||  | ...|
nkkknRykdilpydktrvklkgsegpsd...YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YDMISVECSdersssvdnLRASYDQSEIAQLRFNVKDLRTPENLHKIKMFVVSGWTSEDETPPTSSIITLIAKVERWQqQSGNGPITVVCSDGIGRSGTF
|. |.||.           . . |..|..   ...|.  .... ...|.. . .|. ..    ..|.. || |||... .. .||..|.||.|.||.|||
ygdikvelk.........ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtf

SALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQE
 ||  .||... |. .||||..| .|  |||.|.. ..|.|.. |..|
valdilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_PTPRG_pd Subfamily PTPRG 140-414 3.8e-56 185.5 In-house 19-289 (563) alignment 
Range on Protein: 140-414
Range on HMM: 19-289/563.0
TRFDSEFKTLNKVSpILPKACYIVASYPENKDKNRYSDILASDFSRVVLTAIDDNEIT-TYINAVHISGYKQQHAFIVTQYPLTATVSDFWRMLSEQDSA
..|. ||. |.. . |  .  .  .. |||| ||||..|.|.| ||| |. . ... .  |||| .| ||....|||.||.||. |. |||||. || .|
igfseefealqset.iskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnva

CVVLFQP---TEEGDFPQFWPEVGKETYDMISVECSDERSSSVDNLRasydqsEIAQLRFNVKDLRTPENLHKIKMFVVSGWTSEDetPPTSSII--TLI
 .|.       .  . ...||. . |||. ..|   .|   .. . |      ..    ...|. .  .. .... .  . |   .   |..|.   . .
iivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvr......tlviknlklkkkkqcdteklvrqyhytkWPdhg..vPehslpvLifv

AKVERwQQQSGNGPITVVCSDGIGRSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYLAA
 | ..  ...  |||.| || |.||.||. .| ..|.... |....|.. .| .|  |. ||.|  .| |.| |..| .|.
kkssa.ankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias
subfamily_PTPRK_pd Subfamily PTPRK 164-410 4.9e-56 184.8 In-house 38-275 (314) alignment 
Range on Protein: 164-410
Range on HMM: 38-275/314.0
ASYPENKDKNRYSDILASDFSRVVLTAIDDNEITTYINAVHISGYKQQHAFIVTQYPLTATVSDFWRMLSEQDSACVVLFQPTEEG---DFPQFWPEVGK
|   ||..|||. |||| | |||.|..||..  . ||||  | .||. .||||||.||  || ||||.. ....|..|. .   |       ..||| ..
akkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedte

EtYDMISVECSDERSssvdnlrasyDqSEIAQLRFNVKD-LRTPENLHKIKMFVVSGWTSEdETP-PTSSIITLIAKVERWQQQsGNGPITVVCSDGIGR
  |. | ||. .             . .|. .  |.|.   |. |. .... |   ||..  ..|    ....|...|. .|.. ..|.| | || | ||
v.ygdikvelvetel..........l.aelvvrifrveklargqeeirevrqfqflgWpdh.dvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGr

SGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQE
.||| |. .||. .. |.|.|| .|.|..|  .. .|.|.  ||||. .. |
tGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_CG7180_pd Subfamily CG7180 138-416 1.7e-55 182.8 In-house 11-294 (296) alignment 
Range on Protein: 138-416
Range on HMM: 11-294/296.0
KMTRFDSEFKTLNKVSPILPKACYIVASYPENKDKNRYSDILASDFSRVVLTAIDDNEITTYINAVHISGYKQQHAFIVTQYPLTATVSDFWRMLSEQDS
|. .|  |.| . |. | |       .   ||..|||. ...  |. ||||. .| .| . |||||.. .. .....|||. | . || .|||.. ....
krrkfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeei

ACVV-LFQPTEEGD-FPQFWPEVGKETYDMISVECSDERSSSVDNLRASYDQSEIAQLRFNVKDLRTPENLhkIKMFVVSGWTSEDETPPT-SSIITLIA
 .|| | ....    .|..||. .|| |  | ||   |.. .  . |    . .|  |  . |.  ... .  .|.| .  | .||. |   ...| |. 
savvvLtktfdfakmypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRi..vklfqlteWeledkvPlstnalielrr

KVERWQQQS----GNGPITVVCSDGIGRSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYLAAFD
.|. |...      .||. ||.||| .||| . |.   || |..|. .|| .|.| .|. ||.|| .  |||.|   ..|.. .. 
rvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 140-416 4.5e-55 181.9 In-house 22-287 (305) alignment 
Range on Protein: 140-416
Range on HMM: 22-287/305.0
TRFDSEFKTLNKVspilPKACYiVASYPENKDKNRYSDILASDFSRVVLTAIDDNEITTYINAVHISGYKQQHAFIVTQYPLTATVSDFWRMLSEQDSAC
. .. ..|.| .     ....  | .  .|| |||...|   |..|. ||. .... . |||| .. |||.....||.| ||  ||.||||.. |     
kgleaqykslyee....eesid.vgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvst

VVLFQPTEEGD---FPQFWPEVGKE--TYDMISVECSDERSSSvdnlrasydQSEIAQLRFNVKDLrtPENLHKIKMFVVSGWTSEDETPPTSSIITLIA
.|..  . ||.     |.|||  .|   .. .||| ..|.. |         .  . .|.  ..|    .. . .  . .  |  .     ..|...|| 
ivmltklveggkdkCrqYWpesktekkefgefsvelksektas.........dyieRklkisiede..dkesrtvlqyqltdWPdhGvpqfatsllslik

KVERWQQQSGNGPITVVCSDGIGRSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYLAAFD
.|.. |... . |..|.||.|.||.|.| |.   |||.| |.|.|| . .|..|  |...|.| ..| |.| |..|.. ..|
rvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgd
0045098 (Phosphotyrosine protein) phosphatases II 159-414 1e-54 181.2 In-house 23-274 (278) alignment 
Range on Protein: 159-414
Range on HMM: 23-274/278.0
ACYIVASYPENKDKNRYSDILASDFSRVVltaiddneitTYINAVHISGYkqQHAFIVTQYPLTATVSDFWRMLSEQDSACVVLFQPTEEG---DFPQFW
  . .| |..|.|||||.|||. |.|||.           |||| .|.||  ...||.||.||  ||.|||||| |... ..|   . .|.    ..|.|
seitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqyw

PEVGKETYDMISVECSDERSSsvdnlrasydqSEIAQLRFNVKDL---RTPENLHKIKMFVVSGWTSEDETPPT--SSIITLIAKVERWQQ---------
|| | .||....|.. .|              ...   ...| .|   |.    ......   .|   .  . .  .|.. |.  ......         
peggsltygdftvtllseevl...........ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllss

---QSGNGPITVVCSDGIGRSGTFSALYSVLERVkiEQVIDVLQAIKAMRIPRPG-LVKTTAEYKFIHYAVQEYLAA
   ....||. | || |.||.||. |.| .||..  |...|.|.|.| .|  |||  | .   |.|......|.|  
lllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 130-421 1.4e-54 180.0 In-house 10-287 (287) alignment 
Range on Protein: 130-421
Range on HMM: 10-287/287.0
MEDVDKELKMTRFDSEFKTLNKVSPILPKACYIVASypENKDKNRYSDILASDFSRVVLTaiddNEITTYINAVHISGYKQQHAFIVTQYPLTATVSDFW
. . ...   . |   |..|..|.    .    .||  .||||||...||  |  ||.|     .|   |||||.| |||...|||... |.. |. .||
fvakghakgnegfknqftvleqvtqredevthnias..qnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfW

RMLSEQDSACVVLFQPTEEGD---FPQFWPEVGKETYDMISVECSDERSSsvdnlrASYdqseiAQLRFNVKDLRTPENLHKIKMFVVSGWTSEDETPPT
... ..    .|.    .| |     |.|||    ..   ..|  .|  .      |.|      . ...||     .. ...| . .  | |. . .  
kliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevn......agy.....ierklevknknkagdkqqvkqyqitnWdstgkvtep

SSIITLIAKVERWQQQSGNGPITVVCSDGIGRSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYLAAFDDYANF
 .|. .| .  . |...||..| | |||..|||..| |    ....| | ||||.| .| .|| .|| |.|...||||  .|.||| .|. |..|
qtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysdf
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 3-149 1.8e-54 179.9 In-house 171-318 (318) alignment 
Range on Protein: 3-149
Range on HMM: 171-318/318.0
EKEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYN-PPDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYT
|.|.|.|.|.|.| |||.|||| .. .|.. |.|.... ...|||...|||||||| |.||..|..|.|..||. .|.|..|  ||..| .|||||.||.
eeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqye

FCHDAVLEAIQCGNTQILAHDLRITLSRMEDVDKELKMTRFDSEFKTL
|..|..|||...|.|.. |.|||  . .....| |  .|..| ||. |
fiydvllealasgdtevdasdlrsrirelreqdpesgttemdaefqrl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 3-147 8.6e-53 174.5 In-house 174-319 (319) alignment 
Range on Protein: 3-147
Range on HMM: 174-319/319.0
EKEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVR-AYNPPDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYT
| | ||||.|..| ||||.|||. |..|.. .|.| . . ...||...|||||||| |||||.||||.||. |. ||.|..|  ||| |  |||..|||.
evetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYk

FCHDAVLEAIQCGNTQILAHDLRITLSRMEDVDKELKMTRFDSEFK
|...|.|||...|.|.|   |||  | .... . .  .| .. ||.
fiyealleaveagdteievqdlrdrlkqlaekvadtgetglerefq
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 3-118 8.8e-53 174.5 In-house 181-297 (298) alignment 
Range on Protein: 3-118
Range on HMM: 181-297/298.0
EKEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAyNPPDAG--PVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQY
|..||||.|.|||.|||.||||. |..|...|.||| .. .||  |||..||||||||||||.||..|.||..|...|.|..| .||..|...|||||||
eekerevrqlhftsWpdkgvpenatsvldllrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqY

TFCHDAVLEAIQCGNTQI
.|...|||||....|..|
vfiyeavlealdsfndei
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 127-418 1.1e-51 171.0 In-house 23-298 (319) alignment 
Range on Protein: 127-418
Range on HMM: 23-298/319.0
LSRMEDVDKELkmTRFDSEFKTLNKVSPILPKACYivASYPENKDKNRYSDILASDFSRVVLTAIDDNEITTYINAVHISGYKQQHAFIVTQYPLTATVS
||  .|.|..|  |..  ||. . |... | .  .  |  ..||||||. .||| | ..| |  ..  | . |||| ...||...  .| .| ||  |. 
lsnksdfdddl..tklevefrracklgvnladqtf..anldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntla

DFWRMLSEQDSACVVLFQpteEGDFPQFWPEVGKETYDMISVECSDERSSSVdnlrasydqseIAQLRFNVKDLRTPENLHKIKMFVVSGWTSEDETPPT
|||||. |.... .||.    .    |.||  ......   |. .    ..             .   ... .    ..  ||. |   ||        .
dfWrmiweyncstivllt...kdkcsqywplkivikeerfkvkvdsveetae...........yvvrdielsedgkekdirkitqfhflGwpdvGvpdyp

SSIITLIAKVERWQ-QQSGNGPITVVCSDGIGRSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQE-YLAAFDDY
| ...|. ||.  . .. .. .| | || |.||.|.. .|  .|.|.| |. .|| . .. .|  |. ||.  ..||||. |. | .| .. | 
sdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdv
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 139-409 1.7e-51 170.0 In-house 20-276 (288) alignment 
Range on Protein: 139-409
Range on HMM: 20-276/288.0
MTRFDSEFKTLnkvSPILPKACYIVASYPENKDKNRYSDILASDFSRVVLTAIDDNEITTYINAVHISGYKQQHAFIVTQYPLTATVSDFWRMLSEQDSA
 | | .|...|   ...  .    ... ..|..|||| .||. |. || |.  .... . |||| .| |.|.....| || ||..|| |||..  |... 
rtgfseeynsL...aalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenkts

CVVLFQPT-EEGD--FPQFWPEVGK-ETYDMISVECSDERsssvdnlrasyDQSEIAQLRFNVKdlRTpENLHKIKMFVVSGWTSEDETPPTSSIITLIA
 .| ..   |.|.    ..||. .| . |  . |.  ...           .. .. . .. ..  .. ..  .|. .   .|. ..    .  .. |. 
tivmltelveggktkCeeYWPdadkpknyGsvtvtlvesk...........eledfvlrkllle..kk.kteleitqyqylaWpdhgvPeskapllellr

KVERWQQQSgNGPITVVCSDGIGRSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQ
.|.  .|.   |||.|.||.|.||.||| ||  ....|. |..|||. ... .|  |. ||.|.  | ||. .. 
qvkvanqad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_PTPRB_pd Subfamily PTPRB 139-413 5.3e-51 168.4 In-house 24-286 (293) alignment 
Range on Protein: 139-413
Range on HMM: 24-286/293.0
MTRFDSEFKTLNKVSPilpKACYIVASYPENKDKNRYSDILASDFSRVVLTAIDDNEITTYINAVHISGYKQQHAFIVTQYPLTATVSDFWRMLSEQDSA
 .||  |...|..|     .    .|. ..|..||||..||. | ||| |.|..|.. . |||| .|.||.... ||.|| ||  || |||||. |. | 
dlrfseeyeelkavgk...dqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkss

CVV-LFQPTEEGD--FPQFWPEV-GKETYDMISVECSDERsssvdnlrasyDQSEIAQLRFNVKDlrtPENLHKIKMFVVSGWTSEDETPPTSSIITLIA
 .| | |  |.|     ..||.     .|  |.|.   |.           .... .   ....     .. .|.. .    |.  .    |....... 
iivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaee...........eledwvirelkiek...ekeerkvrqyhftsWpdhgvPektktlldfvr

KVERWQ-QQSGNGPITVVCSDGIGRSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYLA
.|.... ... ..||.| || |.||.||| ||  .|.... |...|..  . ..|  |  ||.| ..| ||| .|...| 
tvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 2-131 2.4e-50 166.4 In-house 173-303 (305) alignment 
Range on Protein: 2-131
Range on HMM: 173-303/305.0
AEKEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNPPDAG-PVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQY
 .||.| | |...| |||||||...|..| . .||.     | | |...||||||||.|.||..| .|.|...| ..|.|...  ||..|  |||| .||
edkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqY

TFCHDAVLEAIQCGNTQILAHDLRITLSRME
.|.|||. | |.||.|.|.  .||. . ...
vflhdaldelitcgdtsiigsnlrarvnklk
subfamily_PTPRK_pd Subfamily PTPRK 4-148 4.5e-50 165.3 In-house 170-314 (314) alignment 
Range on Protein: 4-148
Range on HMM: 170-314/314.0
KEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNPPDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYTFC
.| |||.||.|. ||||.|| . |..|.. ||| . ....||....||||| ||.||||.|| .|| .. |. .|.|| |  ||.|.. ||.|||||.|.
eeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfi

HDAVLEAIQCGNTQILAHDLRITLSRMEDVDKELKMTRFDSEFKT
.|..|||  ||.| | . ... .   .  .| . . ...  ||.|
ydvileaclcgetaipvsefkalylesirldpqtnssqlkeefqt
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 145-417 3.6e-49 162.8 In-house 3-261 (284) alignment 
Range on Protein: 145-417
Range on HMM: 3-261/284.0
EFKTLNKVSPilPKACYIVASYPENKDKNRYSDILASDFSRVVLTAIDDNEITTYINAVHISGYKQQHAFIVTQYPLTATVSDFWRMLSEQDSACVVLFQ
||. . |...  . .    |  ..||||||. .||| | ..| |  .. .| . |||| .|.||.... .| || ||  |. |||||. |.... .||. 
efrracklgv..ngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt

pteEGDFPQFWPEVGKETYDMISVECSDERSSSVdnlrasydqseIAQLRFNVKDLRTPENLHKIKMFVVSGWTSEDETPPTSSIITLIAKVERWQ-QQS
   .    |.||  ......   |. .    |.             .   ... .    ..  ||. |   ||        .| ...|. ||.  . .. 
...kdkcsqywplkivikeerfkvkvdsveesee...........yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltsken

GNGPITVVCSDGIGRSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQE-YLAAFDD
.. .| | || |.||.|.. .|  .|.|.| |. .|| . .. .|  |. ||.  ..||||. |. | .| .. |
hranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsd
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 163-412 1.2e-48 160.7 In-house 43-279 (315) alignment 
Range on Protein: 163-412
Range on HMM: 43-279/315.0
VASYPENKDKNRYSDILASDFSRVVLTAIDDNEITTYINAVHISGYKQQHAFIVTQYPLTATVSDFWRMLSEQDSACVVLFQPTEEGDF---PQFWPEVg
||   |||.|||| .|.| | ||| |  .. .. . |.||  | ||.... .| .| |..|.| ||||.. |.| . .|... . ||.     ..||.  
vakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.

KETYDMISVECSDERSSSVDNLRASydqseiaqlrfnvkDLRTPENLHKIKMFVVSGWTSEDETPPTSSIITLIAKVERWQQQSGnGPITVVCSDGIGRS
| .|  |.|   .|   .    |.                    .|....  . .. |   . .  | ... || .| .....|  |.| | ||.|.||.
kviyGkitvtrkseevnteytvrtl..............svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrt

GTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYL
||| .| .||.....|..||| ..|. .|  | ..|.. ..|.||. |. | .
Gtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletf
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 141-412 4.3e-48 159.1 In-house 24-288 (325) alignment 
Range on Protein: 141-412
Range on HMM: 24-288/325.0
RFDSEFKTLNKVSPIlpkaCYIVASYPENKDKNRYSDILASDFSRVVLTAIDDNEITTYINAVHISGYKQQHAFIVTQYPLTATVSDFWRMLSEQDSACV
 |  ||. |  . .|     . ||  ||||.|||. ...| | ||||| . .|.  . |||| ..  .|... |. .| |||||. |.||.. .  .. |
gfahefgllpsddgi....akkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvv

VLFQPTEEGD--FPQFWPEV-GK-ETYDMISVEcsdersssvdnLRASYDQSEIAQLRFNVKDLRTPENLhKIKMFVVSGWT--SEDETPPT-SSIITLI
|.    ..|.    ..||.  ||  |.  . |.           ||.  . |.  . ...||. .  | .  .| | . .|     .. | |  ||. |.
vvlneldlgkdrcavywpkemgksktfGglevk...........lrtieeisdyvhrvldvkqvkkGetr.svkqfqlqswddmGvqkrpatlisilqlv

AKV-ERWQQ-QSGNGPITVVCSDGIGRSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYL
 .| || .    . .|| | ||.|.||.|.| .|||.|..|  |  .|... .| .|  || .|.|. .| .|. |. |..
kavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay
0037934 (Phosphotyrosine protein) phosphatases II 163-412 8.8e-48 158.3 In-house 4-242 (243) alignment 
Range on Protein: 163-412
Range on HMM: 4-242/243.0
VASYPENKDKNRYSDILASDFSRVVLtaidDNeiTTYINAVHISGYKQqhaFIVTQYPLTATVSD----FWRMLSEQDSACVVLFQPTEEG---DFPQFW
.|..|||..||||||||. |.|||.|    ..  . |||| .| ....   .|.||.||. || |    ||||| |... ..| . ...|    . .|.|
iallpenlsknrysdilpydhsrvkl....eg..sdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PevGKETYDMISVECSDERSssvdnlrasydQSEIAQLRFNVKDLRTPENLHKIKMFVVSGWTSEDETPPTSSIITLIAKVERWQQQ-------SGNGPI
|  |..||. ..|.. .|..            ... .  . .. | ...  . .  .   .|   .  . ..... .. .|  ....       ...||.
p..gevtygdftvtllseeh...........lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpv

TVVCSDGIGRSGTFSALYSVLERVkieQvIDVLQAIKAMRIPRPG-LVKTTAEYKFIHYAVQEYL
 | || |.||.||. |.| .|...   . .|...|.| .|  |||  | |   |.|...|..|.|
lVHCsaGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 137-411 2.3e-47 156.2 In-house 3-265 (283) alignment 
Range on Protein: 137-411
Range on HMM: 3-265/283.0
LKMTRFDSEFKTLNKVSpiLPKACYIVASYPENKDKNRYSDILASDFSRVVLTAIDDneitTYINAVHIS---GYKQQHAFIVTQYPLTATVSDFWRMLS
|. . ..  ...|...|  .|.    .||  ||| |||. .|.. |  || | .       .|||||.|     |||.. .|..| ||  || |||.|. 
lrvnnnklfrevlkrls..vpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvf

EQDSACVVLFQPTEEGD---FPQFWPEVGKETYDMISVECSDERSSSvdnlraSYDQSEIaQLRFNvkdLRTPENLHkIKMFVVSGWTSEDETPPTSSII
... ...|.. .  |.      |.||. | | |    |   .| .|       |. . |.  || |     . ..|  .  . | .|.. .| ..  |..
dekitaivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsn......sfiikel.llrvn...ssakstll.lahyqvidWleygeqaiinslv

TlIAKVERWQQQSGNGPITVVCSDGIGRSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEY
  . ||   |..| .||| | || ||||...| |. . .. .. | |.|| . .| ||  |...|.|   ||..| .| | 
k.fnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleq
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 140-411 3.5e-46 152.4 In-house 6-258 (267) alignment 
Range on Protein: 140-411
Range on HMM: 6-258/267.0
TRFDSEFKTLNKVSPILPK-ACYIVAsypENKDKNRYSDILASDFSRVVLTAIDDNeittYINAVHISGYKQQHAFIVTQYPLTATVSDFWRMLSEQDSA
. .. ||. ..|.|..  . ...|     .|...||. | |  | .||.|   ...    |||| .. |||...|||||| ||  |..||. .. .|. .
ceiekefelikkisdtsstisqsiae...knqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvp

CVVLFQPTEEGDFPQFWPEV-G-KETYDMISVECSDERSSSvdnlraSYdqsEIAQLRFNVKDlrtpENLHKIKMFVVSGWTSEDETPPTssIITLIAKV
 .|| ... ... ..|||   |  . |. ..|| | |.          |   .|  | ...|.    |. |.. ..    |  . .  |   .  |.. .
vivlltkvftdnirlfwPPkmgqakkyqdltvehslekeen......dy...qiitlelkfkn....esahnvtlyyykkwnintnnkpy..lkplfgil

ERWQQQSGNGPITVVCSDGIGRSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEY
 . | . || |. | ||||.||||||  ..| |||.| |.| |. . .. .|  |.|||.|  .| .||  . ||
aknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 3-114 3e-45 149.4 In-house 133-245 (250) alignment 
Range on Protein: 3-114
Range on HMM: 133-245/250.0
EKEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNPP-DAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYT
...|| |.|.||.|||| ||||. ||.|.....|.| ..  ...|||..|||||||||.||.|||.|.|.. |  .|.|...  ||. |  .|...||| 
kaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyv

FCHDAVLEAIQCG
|.. ..|.|... 
fvyeiilkaldsv
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 133-413 5.2e-45 148.6 In-house 12-278 (315) alignment 
Range on Protein: 133-413
Range on HMM: 12-278/315.0
VDKELKMTRFDSEFKTLNKvSPILPKacyIVASYPENKDKNRYSDILASDFSRVVLTAIDDNEITTYINAVHISGYKQQHAFIVTQYPLTATVSDFWRML
|.|. . . |  ||. |    .| ..    ||  ..|  |||| .||  | .||.|  |||.    |||| .| ......|.| .| || |.|.|||||.
vnknrhtalfseefhdlpd.Pdiyrq...rvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmv

SEQDSACVVLFQPTEEGDF---PQFWPEVGKEtydmiSVECSderSSSVDNLRASYDQSEIAQlRFnvkDLRTPENLHKIKMFVVSGWTSEDETPPTSSI
 ... . .|. .  .|||     |.||.   .     |||     | .|. |  . |   .|. ..    .|  |. ...  |   .|  .     |||.
lqekvttivmvtkkqegdkikcrqywPdrkad.....svefG...sikvellsleadtdgvar.kl...vtrkseesrtvtqfqftewPdkGvdkqtssl

ITLIAKVERWqQQSGNGPITVVCSDGIGRSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYLA
. || .|    ... . .. | || |.||.| . .. .|....| ....||.. .| .|  || ||.|  || ||. ||.|.| 
lklikevkad.ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_PTPN12_pd Subfamily PTPN12 140-412 8.7e-45 147.8 In-house 8-277 (290) alignment 
Range on Protein: 140-412
Range on HMM: 8-277/290.0
TRFDSEFKTLNKVSPILPKAC---YIVASYPENKDKNRYSDILASDFSRVVLTAIDDNEITTYINAVHISGYKQQHAFIVTQYPLTATVSDFWRMLSEQD
 .| .||..| |.|  . .       ... .||. |||| |||  |.|||.|. |...|   |||| .| | ......| .| ||..|..|||||. |..
eefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiwekn

SACVVLFQP-TEEGD--FPQFWPEVGKETY--DMISVECSDERSSSVDNLrasydqseIAQLRFNVKdlrtpENLHKIKMFVVSGWTSEDETPPTSSIIT
   ||.     | |     ..||| |.|.   . ..|....|.  . | |        | .|. ...     .. .|.. |    |   .    ..|.. 
veivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddfl........irtLkveaq.....kesrkvyqfhYtaWPDhgvPssakslle

LIAKVERWQQqSGNGPITVVCSDGIGRSGTFSALYSV---LERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYL
||..|.. |. | . |. | || |.|| ||  |.  |   |.. ||.. .|| . .  .|  |. ||.|   |.... || |..
lielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_PTPN6_pd Subfamily PTPN6 116-414 2e-44 146.8 In-house 2-299 (306) alignment 
Range on Protein: 116-414
Range on HMM: 2-299/306.0
TQILAHDLRITLSRMEDVDKELKMTRFDSEFKTLNKVSpILPKACYIVASYPENKDKNRYSDILASDFSRVVLTaiDDNEI-TTYINAVHISGY--KQQH
|..||....   |..|  ...|. . |  ||..|..      .     .. |||| ||||  ||  | .||.|.  ... . ..||||  |..   ....
tsllakeieqrvselekeeeslekagfeeefeelqqee.akkllsrkegakpenkeknryknilPfDhtrvilk..epsvpgsdyinanyikkevkgsdk

AFIVTQYPLTATVSDFWRMLSEQDSACVVLFQPTEEG---DFPQFWPEVG-KETYDMISVECSDERsssvdnlrasyDQSEIAQLRFNVKDLRTPENLHK
..| ||  |..||||||||. ...|  .|.     |       ..||..  ||.|  |||.. .|.           ....    ...|.  .. .. ..
syiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvsek...........sladYilRelsvskkkkkkeere

IKMFVVSGWTSEDETPPTSSIITLIAKVERWQQQSG---NGPITVVCSDGIGRSGTFSALYSVLE---RVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYK
.  .    |  ..    .. .. .. .|.| |...    .||| | ||.|||| |||  .  .|.   . ...  ||. ...| .|  | |||.| . ||
vfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqyk

FIHYAVQEYLAA
|...|...|. .
fvykaikkyiet
subfamily_PTPRA_pd Subfamily PTPRA 3-139 2.1e-44 146.8 In-house 187-323 (330) alignment 
Range on Protein: 3-139
Range on HMM: 187-323/330.0
EKEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNPPDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYTF
||..| |.||||| ||| |||  |  .| . ..|.. |.  |||...||||||||.|||||.||.|.||.||  .|.|. |  ||..|. ||||.|||.|
ekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyef

CHDAVLEAIQCGNTQILAHDLRITLSRMEDVDKELKM
.. ..||    |.|.. .  |   | .. .  .... 
iykvlleyylygdteldvsslekhlqklynkitgtdk
subfamily_PTPRG_pd Subfamily PTPRG 4-124 9.3e-44 144.6 In-house 180-300 (563) alignment 
Range on Protein: 4-124
Range on HMM: 180-300/563.0
KEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNPPDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYTFC
..|..|.|.|.| ||||||||...  | | ..  | |. .|||...||||||||.||.||.|..| ....|.. ..|. .  .|..|  .|||||||.| 
dteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYifl

HDAVLEAIQCGNTQILAHDLR
|||.||||. ..|..||....
hdalleaiasketellaeqve
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 138-420 3.6e-43 142.4 In-house 13-301 (301) alignment 
Range on Protein: 138-420
Range on HMM: 13-301/301.0
KMTRFDSEFKTLNKVSpilPKACYIVASyPENKDKNRYSDILASDFSRVVLTAIDD--NEITTYINAVHISGYKQQHAFIVTQYPLTATVSDFWRMLSEQ
. ..|....|.|....   .| | .  |  |||  ||. .|   |  |..|.   .     ..|||| .|.||.....||..| |.  |. ||||.. ..
hsnkfeeqykelkege...dksctvgls.eenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqe

DSACVVLFQPTEEG---DFPQFWPEVGKETYDMISV--ECSDER---SSSVDNLR-ASYDQSE--IAQLRFNVKDLRtpeNLHKIKMFVVSGWTSEDETP
  . .|    ..||      |.||.  .|....  .  . ..|    .  . .|    .| |.    . .|.||  .   . ...  . |  |  .   .
kpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk...sswdvlqlqvtdWpqdGvvr

PTSSIITLIAKVERWQQQSGNGPITVVCSDGIGRSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYLAAFDDYAN
    ..  | .|   ||. | ||. | |||...|||.. ..   || .| | |.|| | .||.|  .|| |.|   | .|. ....||.  . |||
eprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstyan
subfamily_PTPN9_pd Subfamily PTPN9 157-412 4.1e-43 142.5 In-house 30-290 (297) alignment 
Range on Protein: 157-412
Range on HMM: 30-290/297.0
PKACYIVASYPENKDKNRYSDILASDFSRVVLTAIDDNEITTYINAVHISGYKQQHAFIVTQYPLTATVSDFWRMLSEQDSACVVLFQPTEEGD---FPQ
..  . ..  . |  ||||.|.|  | .||||. .|..| . |||| .. ||||..||| || ||  ||||||||. ||.   .|.   ..|       |
veGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgq

FWPEVGKETYDMISVecsderssSVDNLRASYDqSEIAQLRFNVKDLRTPENlHKIKMFVVSGWTSEDETPPTSSIITLIAKV------------ERWQQ
.||.  ... .  ..        || |.      ..  .  ...|. .| |.  |.  | . .|        ..|.. .. ||            ..|. 
yWpleeessaefgdl........svsnveveee.edykvrvleiknvktees.rkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkg

QSGNGPITVVCSDGIGRSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYL
.  . || | || ||||.||| .|   |.|.. ....|| ...| .|  |   ..|   |.| . || || 
hpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 156-416 1.3e-42 140.9 In-house 35-288 (297) alignment 
Range on Protein: 156-416
Range on HMM: 35-288/297.0
LPKACYIVASYPENK---DKNRYSDILASDFSRVVLTAIDDNEITTYINAVHISGYKQqhAFIVTQYPLTATVSDFWRMLSEQDSACVVLFQPTEEGD--
||.|    .   |.|   .|.||..|| .|.||| |  ..|.    |.|| .. |.|.   .| || |  ||| |||.|. ... . .|. .  .|.|  
lpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkk

FPQFWPEVGKETYDMISVECsdersSSVDNLRAsYDQSEIAQLRFNvkdlrtPENLHKIKMFVVSGWTSEDETP--PTSSIITLIAKVERWQQQSGNGPI
  ..|.. |  |.  .||.      .||.. .  . . |.   . .      . . . .| .    | ....     .||.. ||  |.   .|  .||.
caryWsdkgvttfGdvsvvl.....lsvsereG.fikrelevtkgk......akarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPl

TVVCSDGIGRSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYLAAFD
 | |. |.|| | . .. ||. ..| |. .|... .| .|  || ||.|  .|||.. || |.| . |
lvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsed
0040438 (Phosphotyrosine protein) phosphatases II 3-124 2.8e-42 140.5 In-house 168-289 (317) alignment 
Range on Protein: 3-124
Range on HMM: 168-289/317.0
EKEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNPPDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYTF
..|.|.|..||.| |||||||..|. .|.| ..||...... |||..||||||||.||||... ||.... |  .|... |..|| .|  .|||.||| |
dsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrf

CHDAVLEAIQCGNTQILAHDLR
..||.|| .....| . |..| 
lydalleylkrkltlepaselk
0050432 (Phosphotyrosine protein) phosphatases II 3-115 3.5e-42 140.2 In-house 193-303 (308) alignment 
Range on Protein: 3-115
Range on HMM: 193-303/308.0
EKEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNPPdaGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYTF
..|.|.|..||.| |||||||..|...|.| ..|| ..|.  ||...||||||||.||||..| .|.....|  .|.|..|..||..|  ||||.||| |
dgesrtvthfhytnWpdhgvPpspeilldflelvrkslpg..gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylf

CHDAVLEAIQCGN
...|.|| ...  
lyralleylklkl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 142-413 4.7e-42 139.0 In-house 17-277 (281) alignment 
Range on Protein: 142-413
Range on HMM: 17-277/281.0
FDSEFKTLNKVSpilPKACYIVASYPENKDKNRYSDILASDFSRVVLTAIDDNEITTYINAVHISGYKQQHAFIVTQYPLTATVSDFWRMLSEQDSACVV
| .|...|...     .     .  .||. |||||.| | | .||..|  ..|. | |||| ...|||.....|.|| |. |.. .||.|. ||.   .|
fieeyeklaaig...vdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaiv

L-FQPTEEGDF--PQFWPEVGKetydmiSVECSDersSSVDNLRASyDQSEIAQLRFNVkdLRTPENLHKIKMFVVSGWTSEDETPPTSSIITLIAKVER
.  .  |.|     ..||.  .      ... .|     | ..... .... .. .|..   |.  .  ... .    |        |. ..   ..|..
mvtreieagklkChrYWPddns......elkygd...vtvkstaee.ekatyierkfkl..eresgetreveqlaytaWPdhGvPattkellefrkevlk

WQQQSGNGPITVVCSDGIGRSGTFSALYSVLERVKIE-QVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYLA
 .... . |. . || |.||.||. ||  ....|. | . .|| . .. .|  |  .|.| . |.|.. || ..| 
ltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 133-413 8e-42 138.0 In-house 11-277 (515) alignment 
Range on Protein: 133-413
Range on HMM: 11-277/515.0
VDKELKMTRFDSEFKTLNKvSPILPKAcyiVASYPENKDKNRYSDILASDFSRVVLTAIDDNEITTYINAVHISGYKQQHAFIVTQYPLTATVSDFWRML
|.|. . | |  ||. |     | |..   ||    |  |||| .||  | .|| |  |.||    |.|| .| ... ..|.| .| |. |.|.||||..
vnknrhttlfseefhdlpg.pniypqt...vaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlv

SEQDSACVVLFQPTEEGDFP---QFWPEVGKEtydmiSVECSDERsssVDNLRASYDQSEIAQlrfNVKDLRTPEnLHKIKMFVVSGWTSEDETPPTSSI
 ... . ... .  .|||     ..||..  .     ||.    .   |. .  . .   | .   ... |.  .  . .  |   .|  .   . |||.
lqenvttiamvtklkegdkikcgkyWPdkpgd.....svkfGsik...velvsleactggikr...kltvlkgdd.srtvtqfhfteWPdkGvpkhtssl

ITLIAKVERWQQQSGnGPITVVCSDGIGRSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYLA
. || .|   ..|    |. . || |.|| | . .. ||. ..|  ...||.. .. .|  || ||.|  .| ||. ||.|.| 
lklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 167-413 1.4e-41 137.4 In-house 26-269 (274) alignment 
Range on Protein: 167-413
Range on HMM: 26-269/274.0
PENKDKNRYSDILASDFSRVVL-TAIDDNEITTYINAVHISGYKQ-QHAFIVTQYPLTATVSDFWRMLSEQDSACVVLFQPTEEGDF---PQFWPEVGK-
. .. |||| .||  . |||.| ..  ..| ..|||| .| ||.. ..|.. || ||. ||.|||||. ....  .|.    .| .     ...|.  . 
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

---ETYDMISvecsdersssvdNL-RASYDQSEIAQLRFNVKDLRTPENlhkIKMFVVSGWTSEDETPPTSSIITLIAKVERWQQQSG--NGPITVVCSD
   |.|. ..               .   .. .    .. .| |  . .   .| .  . |  ..    ..... |...||. ....    .|. | || 
eiserygdve............ikvekiverndysvrklvlkylerers...vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsa

GIGRSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYLA
|||| | | |    . ... |.|.|||. .  .|. | |.|.|.  |..|| |. .|| 
GiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
0051299 (Phosphotyrosine protein) phosphatases II 3-111 2e-41 137.8 In-house 178-286 (288) alignment 
Range on Protein: 3-111
Range on HMM: 178-286/288.0
EKEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNPPDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYTF
..|.|.|..||.| |||||||..|...|.| |.|| ..... |||..||||||||.||||..| .|.....|  .|....|..||..|  ||||.||| |
dgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrf

CHDAVLEAI
...|.||..
vyealleyl
subfamily_PTPRB_pd Subfamily PTPRB 3-114 9.6e-41 134.7 In-house 175-288 (293) alignment 
Range on Protein: 3-114
Range on HMM: 175-288/293.0
EKEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYN--PPDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQY
|||||.|.|.||| |||||||| ....|.| |.|| .     ...|...||||||||.|||| .| .|.... |  .|||  || ||..|. .||||.||
ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqY

TFCHDAVLEAIQCG
 | |..||. .. .
ifihqcvldllrkk
0046845 (Phosphotyrosine protein) phosphatases II 3-116 1.2e-40 135.1 In-house 161-279 (284) alignment 
Range on Protein: 3-116
Range on HMM: 161-279/284.0
EKEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNP--PDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAES---SLDIFNYVAYLRTRRTAMVQTE
..|.|.|..||.| |||||||..|. .|.| | || ...  |. ||...||||||||.||||..| .|.....|.    .|....|..||..|  ||||.
tgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtl

EQYTFCHDAVLEAIQCGNT
||| |...|.||......|
eqyrfvyealleylklklt
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 7-123 1.2e-40 134.4 In-house 175-290 (315) alignment 
Range on Protein: 7-123
Range on HMM: 175-290/315.0
REVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNPPDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYTFCHDA
||| |.|.| ||| |||.| .... . |.|. ..  ..|....||||||||.|||| .||.||...||  .|..|..  .|  |  |||. ||| | .||
revvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiyda

VLEAIQCGNTQIlAHDL
.||.. ||.| | |.||
lletfvcgdtsi.aqdl
subfamily_PTPN13_pd Subfamily PTPN13 135-413 1.4e-40 134.3 In-house 6-270 (273) alignment 
Range on Protein: 135-413
Range on HMM: 6-270/273.0
KELKMTRFDSEFKTLNKVSPILpkACYiVASYPENKDKNRYSDILASDFSRVVLTAIDDneittYINAVHIS--GYKQQHAFIVTQYPLTATVSDFWRML
|.|.    . |||.|... |..   |  |.   |||||||| ..|  | .|| | .        |||| .|     |... .|..| ||  ||.|||.|.
kkldqqqPaeefkelrelkpld..tce.vgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmv

SEQDSACVVLFQPTEEGD---FPQFWPEVGKETYDMISvecsdeRsSSVDNLRASyDQSEIAQLRFNVKDLRTPENlHKIKMFVVSGWTSEDETPPTSSI
 ||..  ...     |..     ..|||  ...  . .      |   |..|.   .... .. ...|||... |  ...  .    |   .    . ..
weqkaeviamvtlekekgkvkchrywPesknkklkvsn......r.levellkvq.kldgfvvralavkdsesges.revahlnfvkwPdhgvPssaael

ITLIAKVERWQQqsGNGPITVVCSDGIGRSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYLA
....|.| | |.   .||| | || |||||||. ... ||. .. .. .|| . .. .|  | |.|.|   | |.. |. | | 
lqfvaevrrlqt..dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
0036941 (Phosphotyrosine protein) phosphatases II 4-120 2.5e-40 134.1 In-house 165-286 (297) alignment 
Range on Protein: 4-120
Range on HMM: 165-286/297.0
KEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNPP--DAGPVIIHCSAGVGRSGTFIVIDAMLDRVN---AESSLDIFNYVAYLRTRRTAMVQTEE
.|.|.|..||.| ||||||||.|. .|.| ..|| ...   . |||..|||||||||||||..| ||....    |  .||...| .||..|  .|||.|
gesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtle

QYTFCHDAVLEAIQCGNTQILA
|| |...|.|| .....| . .
qyrflyeallellkkkltkepl
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 165-413 3.5e-40 132.7 In-house 16-265 (270) alignment 
Range on Protein: 165-413
Range on HMM: 16-265/270.0
SYPENKDKNRYSDILASDFSRVVLTAIDDNEITTYINAVHISGYKQQH-AFIVTQYPLTATVSDFWRMLSEQDSACVVLFQPTEEGDF---PQFWPEVGK
..  .|  ||| ||| |  .||.|  ......|.|||| .. |..... ..| .. || .|...||||. |. . ..|.  . ||       ..||.  |
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk

ETYDMisvecsdeRSSSVDNLRASYDQS---EIAQLRfnVKdlrTPENLHKIKMFVVSGWT------SEDETPPTSSIITLIAKVERWQQQSGNG-PITV
|. ..        .   .  |  |  ..    . .||  ..   .  . ...  |    |       .||..  |.........| |....  .. |. |
ekvkl........edgkikvlalseekeegyiltrlr..le...ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllv

VCSDGIGRSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYLA
 ||.|.||.||. ||  ... .. .. .|||. |...|  |. ||... .|.|.. ||.||  
HcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 3-112 2.1e-39 130.3 In-house 171-280 (288) alignment 
Range on Protein: 3-112
Range on HMM: 171-280/288.0
EKEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNPPDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYTF
.|.|.|..|.....||||||||  . .|...| |   |. |.||.|.||||||||.||||..||..|.|..|  .|... || || .|. .|||..|| |
kkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYef

CHDAVLEAIQ
.....|. |.
iyevllslie
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 4-110 2.1e-39 130.1 In-house 133-239 (239) alignment 
Range on Protein: 4-110
Range on HMM: 133-239/239.0
KEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNPPDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYTFC
 ||| | |.|||||||.|||.| ||.| .||..   . | | | .|||||||||.|.|.|||||| . . . ..||||||  .|  |  |||| ||| | 
teeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfi

HDAVLEA
| |||||
hlavlea
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 4-109 8.7e-39 128.1 In-house 134-239 (239) alignment 
Range on Protein: 4-109
Range on HMM: 134-239/239.0
KEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNPPDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYTFC
 ||| | |.|||||||.|||.| ||.| .||..   . | | | .|||||||||.|.|.|||||| . . . ..||||||  .|  |  |||| ||| | 
teeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfi

HDAVLE
| ||||
hlavle
Y_phosphatase Protein-tyrosine phosphatase 3-109 1.4e-38 128.0 Pfam-A 129-235 (235) alignment 
Range on Protein: 3-109
Range on HMM: 129-235/235.0
EKEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNPPDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYTF
|.|.|||||.|.| |||||||| |...| . |.|. .. .. |||..||||||||.|||...|..|....||...|....|  ||..|  |||..||| |
esekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYif

CHDAVLE
...|.||
lykaile
Y_phosphatase Protein-tyrosine phosphatase 3-109 1.4e-38 128.0 In-house 129-235 (235) alignment 
Range on Protein: 3-109
Range on HMM: 129-235/235.0
EKEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNPPDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYTF
|.|.|||||.|.| |||||||| |...| . |.|. .. .. |||..||||||||.|||...|..|....||...|....|  ||..|  |||..||| |
esekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYif

CHDAVLE
...|.||
lykaile
0047943 (Phosphotyrosine protein) phosphatases II 4-111 3.1e-38 127.2 In-house 163-272 (273) alignment 
Range on Protein: 4-111
Range on HMM: 163-272/273.0
KEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNPP--DAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYT
.|.|.|..||.| |||||||.... .| | . || ..    . |||..||||||||.||||..| .||....|  .|....|..||..|  ||||.||| 
gesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyr

FCHDAVLEAI
|...|.|| .
flyealleyl
DSPc_SM00195 3-111 6.3e-38 126.0 In-house 154-262 (263) alignment 
Range on Protein: 3-111
Range on HMM: 154-262/263.0
EKEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNPPDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYTF
..|.|.|.|.... |||||||. .. .|.. | |.  .    ||...||||||||.|||..|| .|.....|. .|||. |  ||. |  ||||.|||.|
keetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlf

CHDAVLEAI
...|.||.|
iyeaileyi
PTPc_SM00194 3-111 6.3e-38 126.0 In-house 154-262 (263) alignment 
Range on Protein: 3-111
Range on HMM: 154-262/263.0
EKEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNPPDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYTF
..|.|.|.|.... |||||||. .. .|.. | |.  .    ||...||||||||.|||..|| .|.....|. .|||. |  ||. |  ||||.|||.|
keetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlf

CHDAVLEAI
...|.||.|
iyeaileyi
subfamily_Ptp69D_pd Subfamily Ptp69D 4-126 2e-37 124.0 In-house 179-301 (307) alignment 
Range on Protein: 4-126
Range on HMM: 179-301/307.0
KEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNPPDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYTFC
...|.| |.|.| |.|  ||| ....| . ..||  .  . .|...||||||||||.|. .| .|....|| ..|||. |  || .|. .||  |||.|.
edsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvfl

HDAVLEAIQCGNTQILAHDLRIT
. |.|. .. |.|..  .||  .
yralldyssygdtdedvddleda
0039614 (Phosphotyrosine protein) phosphatases II 3-115 2.8e-37 124.2 In-house 179-293 (297) alignment 
Range on Protein: 3-115
Range on HMM: 179-293/297.0
EKEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNP--PDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQY
..|.|.|..|..| |||||||.... .| | . || ..   |. |||..||||||||.||||... ||.... |  .|... |..|| .|  .|||..||
ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqy

TFCHDAVLEAIQCGN
 |..||.|| .....
rflydallellkrkl
0045450 (Phosphotyrosine protein) phosphatases II 3-112 4e-37 124.0 In-house 191-305 (307) alignment 
Range on Protein: 3-112
Range on HMM: 191-305/307.0
EKEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNPP--DAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESS---LDIFNYVAYLRTRRTAMVQTE
..|.|.|..||.| |||||||...  .|.| ..||...    . |||..||||||||.||||... ||.....|     .|... |..|| .|  .||..
tgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnp

EQYTFCHDAVLEAIQ
||| |...|.|| ..
eqyrflyeallelll
subfamily_PTPN12_pd Subfamily PTPN12 2-112 6.3e-37 122.0 In-house 165-278 (290) alignment 
Range on Protein: 2-112
Range on HMM: 165-278/290.0
AEKEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNPPDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAE---SSLDIFNYVAYLRTRRTAMVQTEE
|.||.|.|.|||.| |||||||. .. .|.. . || ..  .. |...|||||||| || |.|| . . ..||   ..||.|. |. ||..|.|.|||.|
aqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtke

QYTFCHDAVLEAIQ
||.. . ||.| .|
qyelvykavaelvq
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 3-112 6.7e-37 122.1 In-house 166-277 (281) alignment 
Range on Protein: 3-112
Range on HMM: 166-277/281.0
EKEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNPPDA-GPVIIHCSAGVGRSGTFIVIDAMLDRVNAE-SSLDIFNYVAYLRTRRTAMVQTEEQY
. |.|||.|...| |||||||. ....| ||. |. .. ..   |..|||||||||.||.| .| ....|.|| ..||. . || || .|. ||||  ||
sgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqy

TFCHDAVLEAIQ
.| . |||.|..
efvykavldald
0043336 (Phosphotyrosine protein) phosphatases II 3-110 1.9e-36 121.4 In-house 169-276 (278) alignment 
Range on Protein: 3-110
Range on HMM: 169-276/278.0
EKEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNPPDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYTF
..|.|.| ..|.. |||||||| .. .| | ..|| ..... |||..||||||||.||||... .|.... |  .|... |..||..|  .|||..|| |
dgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrf

CHDAVLEA
...|.|| 
lyealley
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 4-127 6.5e-36 118.8 In-house 170-293 (315) alignment 
Range on Protein: 4-127
Range on HMM: 170-293/315.0
KEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNPPDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYTFC
.| | | ||.|| |||.||..  ...| . . |.| | ..  ....||||||||.| .| || ...... ..|.|.||.|  ||. |  .|||||.|.| 
eesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafi

HDAVLEAIQCGNTQILAHDLRITL
.||||| ..  || ||   .   |
ydavledllwrntlilvihftdhl
PTPc_DSPc_SM00012 9-109 7.7e-36 117.8 In-house 2-105 (105) alignment 
Range on Protein: 9-109
Range on HMM: 2-105/105.0
VKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNPPDA--GPVIIHCSAGVGRSGTFIVIDAMLDRVNAE-SSLDIFNYVAYLRTRRTAMVQTEEQYTFCHD
||..|.| ||||||||....|| . | |.  .   .  .||..||||||||.|||...| .|.....| ...|||..| .||..|  |||||||| |...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AVLE
|.||
alle
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 141-412 7.8e-36 118.3 In-house 11-277 (287) alignment 
Range on Protein: 141-412
Range on HMM: 11-277/287.0
RFDSEFKTLNKVSpILPKACYIVASYPENKDKNRYSDILASDFSRVVLTAIDDnEITTYINAVHISGYKQQHAFIVTQYPLTATVSDFWRMLSEQDSACV
  | |...| . |     | .  |    .  ||||.|.|  | .||.|.|  .   . |||| ....|....|||..| |..||| ||||.. |. || |
dvdkevdalkeds.esstatfkaaeelaavkknryadvlPiddtrvllsaege.lGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasv

VLF-QPTEEGDFP--QFWPEVgkETyDMIsVEcsderSSSVDNLRASYDQSEIAQLRFNVKDLRTpENLHKIKMFVVSGWtSEDETPPT-SSIITLIAKV
..  .  ||.     ..|||   |   |  |        ||  |  .  . | .   . . || | .. . .| . .  |  ..  .||  ..| .. .|
itmtreveearlkcykywPer..ev.Pmr.vG.....GysvvlldydikePeygvralrlidlet.rearvvkqldllsw.PdkvlaPtavglirfvldv

----ERWQQQSGNGPITVVCSDGIGRSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYL
    |  .. |. ||. | .. ||||||.. |.. ...| .    .|| ...  .|  | .||...  ....  |.  | 
kqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyy
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 135-412 8.5e-36 118.2 In-house 15-236 (392) alignment 
Range on Protein: 135-412
Range on HMM: 15-236/392.0
KELKMTRFDSEFKTLNKvSPILPKAcyiVASYPENKDKNRYSDILASDFSRVVLTAIDDNEITTYINAVHISGYKQQHAFIVTQYPLTATVSDFWRMLSE
|. . . | .||. |    .| |..   ||  . |. |||| .||  | .||.|  |||   . |.|| .| ......|.| .| | .|...|||||. .
knrhsalffeefhdlpg.pdiypqt...vaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfq

QDSACVVLFQPTEEGDfpqfwpevgketydmisvecsdersssvdnlrasydqseiaqlrfnvkdlrTPENLHKIKMFVVSGWTSEDETPPTSSIITLIA
.. . ... .  .|||                                                     .. . .  | .. |  .|    |||.. .| 
envttiamvtklkegd...................................................kgddartvaqfhftewPdkdvpkhtssllkfik

KVERwQQQSGNGPITVVCSDGIGRSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYL
.|.  .  .   |. . || |.||.|   .. ||. . |  ...||.. .  .|  || .|.|  .| ||. || | |
evka.dfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledl
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 5-157 9e-36 118.0 In-house 170-322 (515) alignment 
Range on Protein: 5-157
Range on HMM: 170-322/515.0
EEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNPPDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYTFCH
. | | ||||| |||.|||.  ...| . . |.| .   . |.|||||||||| | .| || .. ...   ..|.||.|  .| .|  .|||.|||.| .
dsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiy

DAVLEAIQCGNTQILAHDLRITLSRMEDVDKELKMTRFDSEFKTLNKVSPILP
.|||| .   || |    .   |  .         ...  ||.||. . |  |
gavledllwrntlipvihftdhlqdlhssgdgrgrskmtkefqtlkslcpdpp
0045098 (Phosphotyrosine protein) phosphatases II 4-115 9.1e-36 119.1 In-house 151-276 (278) alignment 
Range on Protein: 4-115
Range on HMM: 151-276/278.0
KEEREVKQFHFTVWPDHGVPEYP--TAILAFRRRVRAYNP-------------PDAGPVIIHCSAGVGRSGTFIVIDAMLDRVnaESSLDIFNYVAYLRT
 |.|.|...|.. |||||||..|  . .| . ...|...              .. |||..||||||||.||..... ||...  |. .|....|..||.
lesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrs

RRTA-MVQTEEQYTFCHDAVLEAIQCGN
.|   .||..||| |.....|| ...|.
qRpglavqnleqyrflyefllelllrgk
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 130-412 1e-35 118.1 In-house 11-279 (439) alignment 
Range on Protein: 130-412
Range on HMM: 11-279/439.0
MEDVDKElKMTRFDSEFKTLNKVSPI-LPKACYIVASYpeNKDKNRYSDILASDFSRVVLTAIDDNEITTYINAVHISGYKQQHAFIVTQYPLTATVSDF
.|..||. |   |. .|...| .||    .|. .  .|  .. |||| |. | |..||.|  |     . |||| .| || ... .| ||.|   |. ||
vekldkn.kqeifkeifekinstspdyaciaslaaqey..dqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddf

WRMLSEQDSACVVLFQPTEEgdFPQFWPEVGKETYDMISVECsdERSSSVDNlrasYDqseIAQ-LRFNVKDlrTPENLHKIKMFVVSGWTSEDETPPTS
||.. |. .. .| .    |    ..||  ..  |  |.| .  .|   . |    |    |     || .|  | |. . .  |    |  ..    .|
wrlviekktvtivmltnlve..sykywpsdaevcygdiavrv..drnielpn....yv...irgfkvfnerd..ttekertvlqfhyiawpdknvpaqas

SIITLIAKVERWQQQSGNGPITVVCSDGIGRSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYL
 .. ..  ..  ...   ||. | || |.||.||  ||   ||..|.|. .|.   .| .|  |  .|.. ..| ||. || | .
hvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
subfamily_PTPN13_pd Subfamily PTPN13 4-112 1.1e-35 118.2 In-house 163-270 (273) alignment 
Range on Protein: 4-112
Range on HMM: 163-270/273.0
KEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNPpDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYTFC
.| ||| ...|. |||||||  .. .| | ..||  .  ||||...|||||.|||||.|.||..|. .. . ..|. . |  || .| ..|||..|| |.
gesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifv

HDAVLEAIQ
. |.||...
ykailevlk
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 3-123 1.3e-35 118.2 In-house 181-303 (319) alignment 
Range on Protein: 3-123
Range on HMM: 181-303/319.0
EKEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNPPD--AGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQY
||. |...||||  |||.|||.||. .. . ..||  .       ....||||||||.|..||.|..|||.. |. .|..|.|  || .|  .||   ||
ekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqy

TFCHDAVLEAIQCGNTQILAHDL
 |.. |.||    |....   |.
kfiysalleehlfghsdvampdf
subfamily_PTPN3_pd Subfamily PTPN3 159-408 3.7e-35 116.2 In-house 31-271 (280) alignment 
Range on Protein: 159-408
Range on HMM: 31-271/280.0
ACYIVASYPENKDKNRYSDILASDFSRVVLTAIDDNEIT-TYINaVHISGYKQQHAFIVTQYPLTATVSDFWRMLSEQDSACVVLF-QPTEEGDF--PQF
    .|  ||| .|||| |||. |  || |.. . . |   |.| . | . ..   .|.|| ||. |..|||.|. ||.|  .|.. . .|.|     |.
laisaarkpenlsknryrdilpydatrvklkesetdyinanyvn.meipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqy

WPEVGKE-TYDMISVECSDErsssvdNLRASYdqseiAQLRFNVKDLRTPENLHKIKMFVVsGWTSEDETPPTSSIITLIAKVERWQqQSGNGPITVVCS
||| ..| .|  .||.|. |      . . ||     .   . .|| .| |. . ...  .  |. ..    ........ .|.. . .. . |. | ||
WPetedeleygefsvkceke......detksy.....vlrelvlkdketkeerkilqlqyl.aWpdhgvPddsadflefvervrklr.sgkeePvvvhCs

DGIGRSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAV
 ||||.| . .|   |  . ... . .|. .. ||  |  ||.|.. |||.  |.
aGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeai
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 3-126 4.2e-35 116.6 In-house 145-270 (284) alignment 
Range on Protein: 3-126
Range on HMM: 145-270/284.0
EKEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNPPD--AGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQY
||. |...||||  |||.|||.||. .... ..||  .       ....||||||||.|..||.|..|||.. |. .|..|.|  || .|. .||   ||
ekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqy

TFCHDAVLEAIQCGNTQILAHDLRIT
 |.. |.||    |....   |.   
kfiysalleehlfghsdvalpdfpay
subfamily_PTPN23_pd Subfamily PTPN23 140-411 7.1e-35 115.2 In-house 15-279 (288) alignment 
Range on Protein: 140-411
Range on HMM: 15-279/288.0
TRFDSEFKTLNKVSPILPKACYIvASYPENKDKNRYSDILASDFSRVVLTAIDDNeittYINAVHISGYKQQ-HAFIVTQYPLTATVSDFWRMLSEQDSA
| .| .|| |..      .   | |    . .|||. |||  | .||.|    |.    |||| .. .   .   ||.|| ||  |..|||.|. || | 
taldkkfkeleqkqdkearkrsi.aiaklyseknrsrdilPyDhnRvklrgskDD....YinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkss

CVVLFQPTEEGDFP---QFWPEVGKE--TYDMISVECSDERSSSVDNLRasydqseiaQLRFNVKDLRTPENLHKIkmfVVSGWTSEDETPPTSSIITLI
 .|. .  || . |   ..|||   |  ... .|| ....|...    |         .|. ...| .. ... ..    .  |..       .... ..
viVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethver.........vlkletldadavksvshl...qltsWpelGvPasPetllqfl

AKVER---WQQQSGNGPITVVCSDGIGRSGTFSALYSVLERVKIEQ-VIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEY
 .||     .|.  . |. | || |.||.|.|. .|.... .. .. ..|..| .. .|  |   |.. ...||   || |.
devesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_PTPRN_pd Subfamily PTPRN 126-412 7.2e-35 115.1 In-house 17-292 (297) alignment 
Range on Protein: 126-412
Range on HMM: 17-292/297.0
TLSRMEDVDKElkMTRFDSEFKTLNKVSPiLPKAcYIVASYPENKDKNRYSDILASDFSRVVLTAIDDNEITTYINAVHISGYK-QQHAFIVTQYPLTAT
 || .||  |.   .|.. |...| .     |..   ||. ..| .|||....|. | ||| |..  ..| . ||||  |     .. |.| || ||..|
vlsyledhlkn..kdrlekewealcayea.epst.kevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplast

VSDFWRMLSEQDSACVVLFQPTEEGDFPQ---FWPEVGKETYDMISVECSDERSSSVDNLRASydqseiaqlrFNVKDLRTPENlHKIKMFVVSGWTSED
|.|||.|. || .. .| . . || .  |   .||. |.|.|..  |.   |   . | |  |          | .|.|.| |    .  |    |..|.
vadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrs..........fylknlqtset.rtvtqfhflswpeeg

ETPPTSSIITLIAKVERWQQQsGNGPITVVCSDGIGRSGTFSALYSVLERV-KIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYL
  . . |.. .  ||..  .     || | |||| ||.|.. ..  ||.|. |  . ||.  ... .|  ||||||| ....|.  || | .
vPasaksllefrrkvnksyrG.rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev
0040439 (Phosphotyrosine protein) phosphatases II 4-111 9.2e-35 115.8 In-house 137-246 (249) alignment 
Range on Protein: 4-111
Range on HMM: 137-246/249.0
KEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNP--PDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYT
.|.|.|.....| |||||||...  .|.| ..|| ..   |. |||..||||||||.||||... ||.... |  .|....|..||..|  .||..||| 
gesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyr

FCHDAVLEAI
|...|.|| .
flyeallell
0049772 (Phosphotyrosine protein) phosphatases II 154-413 2.1e-34 115.1 In-house 31-281 (314) alignment 
Range on Protein: 154-413
Range on HMM: 31-281/314.0
PILPKACYIVASYPENKDKNRYSDILASDfSRVVLTAIDDNEiTTYINAVHISGYkqqHAFIVTQYPLTATVSDF----------WRML--SEQDSACVV
 .||. .. ||....|.||||| |||  | .||.|   . .  . |||| ...|.    .||.||.||  || ||          |||   .....  .|
svlpeltilvadlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdiv

L---------------------FQPTEEGDfpqfwpevgketydmisvecsdersssvdnlrASYDQSEIAQLRfNVKDLRTPENLHKIKMFVVsGWTSe
                      . .  ..                                 . .. .....|. .. . .     . || . .  ..  
msrdevladelsrLdaAlgKtpllildgng................................neptaadlellk.eelydpelferlgikylri.pvpD.

DETPPTSSIITLIAKVERWqqqSGNGPITVVCSDGIGRSGTF--SALYSVLERVKIEQVIDVLQAIKAmRIPRPGLVKTTAEYKFIHYAVQEYLA
...|... .  ... .|..   . .||. | |..|.||.|||   |.   | .| .|.... ....     |.||....  .| ||..|..||| 
gsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefilealleylk
0037934 (Phosphotyrosine protein) phosphatases II 3-109 3.3e-34 113.9 In-house 129-240 (243) alignment 
Range on Protein: 3-109
Range on HMM: 129-240/243.0
EKEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAY--------NPPDAGPVIIHCSAGVGRSGTFIVIDAMLDRVnaesSLDIFNYVAYLRTRRTA-M
....|.| ..|.. |||||||. |. .|.| . ||..        . .. |||..||||||||.||.|... ||...    ..|....|..||..|   .
ddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgka

VQTEEQYTFCHDAVLE
|||..|| |...|.||
vqtpsqyrflyealle
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 5-137 5.5e-34 112.7 In-house 176-314 (325) alignment 
Range on Protein: 5-137
Range on HMM: 176-314/325.0
EEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAY------NPPDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEE
| | ||||..  |.| ||...|...... . | |       |   ..|...||||||||.|.|| . ..|..|  ||..|||..|  ||  | .||.| .
etrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvd

QYTFCHDAVLEAIQCGNTQILAHDLRITLSRMEDVDKEL
||.....|. ||. .|||..    .   || ... .   
qyiliyealveaymsgntdvpvssfeaklsslqernplt
0042113 (Phosphotyrosine protein) phosphatases II 3-110 6.1e-34 112.9 In-house 134-242 (245) alignment 
Range on Protein: 3-110
Range on HMM: 134-242/245.0
EKEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNP-PDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYT
..|.||| ..|.. |||||||...  .| | ..|| .   .. |||..||||||||.||||... ||.....|  ..... |..|| .|  .|||..|| 
ddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyr

FCHDAVLEA
|...|.|| 
flyeallel
subfamily_PTPN6_pd Subfamily PTPN6 2-113 1.8e-33 110.9 In-house 181-299 (306) alignment 
Range on Protein: 2-113
Range on HMM: 181-299/306.0
AEKEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAY----NPPDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNA---ESSLDIFNYVAYLRTRRTAMV
 .|||||| |.||..|||||||. | |.|.| . |..     .  .|||...|||||.|| |||||||..|. ..    .  .|| . | ..|. |  .|
kkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglv

QTEEQYTFCHDAVLEAIQC
|||.|| | . |. . |. 
qteqqykfvykaikkyiet
0041856 (Phosphotyrosine protein) phosphatases II 169-412 7.5e-33 109.0 In-house 1-171 (182) alignment 
Range on Protein: 169-412
Range on HMM: 1-171/182.0
NKDKNRYSDILASDFSRvvltaiddneITTYINAVHISGYKQQHAFIVTQYPLTATVSDFWRMLSEQDSACVVLFQpteegdFPQFWPevgketydmisv
|.|||||||||  |.||            .||||  . |.  .  ||.|| ||  || ||.||| |..  ..|          .. ||            
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt......eelywp............

ecsdersssvdnlrasydqseiaqlrfnvkdlrtpEN-LHKIKMFVVSGWTSEDETPpTSSIITLIAKVERwqqqsGNGPITVVCSDGIGRSGTFSALYS
                                   |.  . .  ..  .|   . .. ..... .| .|..      .||. | || |.||.||. |.| 
...................................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaayl

VLERvkieQvIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYL
....    . ... .|.| .|  ||| | |   | |...|. |.|
mkkl....g.vsleeavklvrsrRpgmvitpnqyfflqlallell
subfamily_PTPN1_pd Subfamily PTPN1 162-410 2.4e-32 106.8 In-house 25-269 (290) alignment 
Range on Protein: 162-410
Range on HMM: 25-269/290.0
IVASYPENKDKNRYSDILASDFSRVVLTAIDDneitTYINAVHISGYKQQHAFIVTQYPLTATVSDFWRMLSEQDSACVVLFQPTEE-G--DFPQFWPEV
 .|  |||...||| |.   | ||..|   |      ||||  .   . .. .|.|| ||. ||. ||.|. ||.| .||..    | .     |.||. 
reaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqg

GKetydMISVECsDERSSSVDNLRASYdQSEIAQLRFNVKDLRTPENlHKIKMFVVSGWTSEDETPPTSSIITLIAKVERWQ-QQSGNGPITVVCSDGIG
 .      .... .. . .|. ..    .|.     .....|.| |  ..|  |    |.        .. . .. || .    .|  ||  . || |||
ee....ekelll.edtklkvkliseer.ksyytvrllelenlktqet.reilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiG

RSGTFSALYSVLERVKIEQV---IDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQE
|||||. . ..| ... ..    .|. . . ..|  | ||..|.   .| . |. |
rsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 4-109 5.9e-32 105.8 In-house 130-237 (237) alignment 
Range on Protein: 4-109
Range on HMM: 130-237/237.0
KEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNP--PDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYT
|| | ..|..||.|||.|||.. .|.| ||...   .|  ...|| ||||||||||.| |.|||||| . . .  .||.|||  .   |  ..||..|| 
kevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyv

FCHDAVLE
| |...||
fihqtile
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 4-117 6.1e-32 105.7 In-house 170-284 (287) alignment 
Range on Protein: 4-117
Range on HMM: 170-284/287.0
KEEREVKQFHFTVWPDHG-VPEYPTAILAFRRRVRAYNPPDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYTF
.....|||...| |...| |.|. | .| . .....   .  .....|||..||||..|. ..  ..... |  .|.|. .   | ..  .||| |||.|
gdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykf

CHDAVLEAIQCGNTQ
  |.||| .....|.
indivleyldsfety
0036282 (Phosphotyrosine protein) phosphatases II 198-406 1.1e-31 105.2 In-house 3-164 (174) alignment 
Range on Protein: 198-406
Range on HMM: 3-164/174.0
TYINAVHISGYKQQHAFIVTQYPLTatvsdFWRMLSEQDSACVVLFQPTEEGD---FPQFWPEvgketydmisvecsdersssvdnlrasydqseiaqlr
.|||| .....     .|..|.||.     ||.|| |... .|| . . .| .   ....|||                                     
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.....................................

fnvkdlrTPENLHKIKMFVVSGWTSEDETPPTSSIITLIAKVERWQQQSGNGPITVVCSDGIGRSGTFSALYSVLERVKiEQVIDVLQAIKAMRIPRPGL
       ..| |..  . ..   .  ...|..| .....  ||........||. | || |.||.||. |.| .| . . | ..|.|. ....|  ||| 
.......lredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgm

VKTTAEYKFIHY
| |   |.|..|
vqtpsQyrflyy
subfamily_PTPN9_pd Subfamily PTPN9 3-110 2.3e-31 103.9 In-house 169-289 (297) alignment 
Range on Protein: 3-110
Range on HMM: 169-289/297.0
EKEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYN-------------PPDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTR
..|.|.|  | |. |||.|||.  ...| ... || .              .|.  |...|||||.||.|||| .|  |.|.. .. .|... | .|||.
teesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtq

RTAMVQTEEQYTFCHDAVLEA
|. ..||.|||.||. |||| 
rafsiqtpeqyefcylavley
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 3-120 7.1e-31 102.4 In-house 173-293 (297) alignment 
Range on Protein: 3-120
Range on HMM: 173-293/297.0
EKEEREVKQFHFTVWPDHGVPE--YPTAILAFRRRVRA-YNPPDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQ
 | .| |||..|. |||. |..    ...| .   ||  ..    ||...||.||||| | .. || .. ... | ..|||..|  ||  |  .|||.||
akarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeq

YTFCHDAVLEAIQCGNTQILA
|.| . |||||. . .|.| |
ykfvyvavleallsedtriqa
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 4-140 1e-30 101.5 In-house 129-268 (392) alignment 
Range on Protein: 4-140
Range on HMM: 129-268/392.0
KEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNPPDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYTFC
.. | | ||||| |||..||.. ...| | . |.|     . |.||||||||||.|  | ||... . .    .|.||.|. .| .|  ||||.|||.| 
ddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafi

HDAVLEAIQCGNTQILAHDLRIT---LSRMEDVDKELKMT
. |||| .   || |    .      ||   | |   |..
ygavledllwrntlipvvhftdhlqdlstssdGdvrskql
subfamily_PTPN1_pd Subfamily PTPN1 4-113 1.6e-30 100.9 In-house 159-273 (290) alignment 
Range on Protein: 4-113
Range on HMM: 159-273/290.0
KEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAY--NPPDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAE---SSLDIFNYVAYLRTRRTAMVQTEE
.| ||. .||.| ||| |||| |.| | |  .||      .| ||..||||||.||||||...|..| .....   ||.|| . .  ||  |. ..|| .
qetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtad

QYTFCHDAVLEAIQC
|  | . |.|| ...
qlrfsylaileGakv
0051429 (Phosphotyrosine protein) phosphatases II 196-414 1.6e-30 102.0 In-house 3-227 (272) alignment 
Range on Protein: 196-414
Range on HMM: 3-227/272.0
ITTYINAVHISGYKQ---QHAFIVTQYPLTATVSDFWRMlSEQDSACVVLFQPTEEGDFPQFWPEVGKETYDMISVECSDERSSSVDN----LRASYDQS
...|||| ...|| .    .... ...||..|. ||||.  |..  ..| . ..|| .. .....    .|  .... ... . .. .    |   . ..
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

EIAQLRFNVKDLRTPENLHKIKMFVVSGWTseDETPPTSSIITLIAKVERwqqqsgNGPITVVCSDGIGRSGTFSALYSVLERVKIEQVID--------V
 .   .. .. | .... ... ...  .|   |   |......|.. . .      .||. | || |..|.||..||. .|..|  |...|        .
dyilrellltlllsagearevmhlhytdwp..dhgvpqeallellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

LQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYLAA
..|.. .|  ||| | | . |.|.. |..|.| .
eeaveelraqrpgavqteeqylflyeallellrs
0051429 (Phosphotyrosine protein) phosphatases II 4-111 2.1e-30 101.7 In-house 117-225 (272) alignment 
Range on Protein: 4-111
Range on HMM: 117-225/272.0
KEEREVKQFHFTVWPDHGVPEypTAILAFRRRVRAynppdAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLD--------IFNYVAYLRTRRTAMVQ
.| ||| ..|.| |||||||.   |.|.. . ...      |||..|||||..|.||..... .| .|..|  .|        ....|..|| .| ..||
gearevmhlhytdwpdhgvpq..eallellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavq

TEEQYTFCHDAVLEAI
||||| |...|.||..
teeqylflyeallell
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1-123 2.4e-30 100.4 In-house 168-291 (439) alignment 
Range on Protein: 1-123
Range on HMM: 168-291/439.0
DAEKEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYN-PPDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQ
|  . || | |||.. |||. ||   . .| | | . . |   . |||..||||||||.|| | .|  |.....|  .||   | .|| .|. |||.  |
dttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcq

YTFCHDAVLEAIQCGNTQILAHDL
| | ..|||| |. |.. ..  ..
yvfiynavledivyGdiavtidef
0041856 (Phosphotyrosine protein) phosphatases II 3-117 9.2e-30 99.0 In-house 73-177 (182) alignment 
Range on Protein: 3-117
Range on HMM: 73-177/182.0
EKEEREVKQFHFTVWPDHGVPEyPTAILAFRRRVRAynppDAGPVIIHCSAGVGRSGTFIVIDAMLDRvnaesSLDIFNYVAYLRTRRTAMVQTEEQYTF
|..||.. |.... |||||||. .  .|.| ..|..    . |||..||||||||.||..... |. .     ...... |...| ||  ||.|..|| |
ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsleeavklvrsrRpgmvitpnqyff

CHDAVLEAIQCGNTQ
...|.|| .....|.
lqlallellllkktr
0036282 (Phosphotyrosine protein) phosphatases II 3-105 1.2e-29 98.6 In-house 63-164 (174) alignment 
Range on Protein: 3-105
Range on HMM: 63-164/174.0
EKEEREVKQFHFTVWPDHGVPEYPTaILAFRRRVRAYNPP-DAGPVIIHCSAGVGRSGTFIVIDAMLDRVNaESSLDIFNYVAYLRTRRTAMVQTEEQYT
| .||.. |.... |||||||. .. .| | ..|. .    . |||..||||||||.||..... || .   ||  |....|. ||. |  ||||..|| 
edlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyr

FCHD
|...
flyy
subfamily_PTPN14_pd Subfamily PTPN14 129-412 1.3e-29 98.2 In-house 12-296 (300) alignment 
Range on Protein: 129-412
Range on HMM: 12-296/300.0
RMEDVDKELKMTRFDSEFKTLNKVSPilpKACYIVASYPENKDKNRYSDILASDFSRVVLTAIDDNeITTYINAVHISG--YKQQHAFIVTQYPLTATVS
|.. ..|.|. ..   |.  . | .    .| . .|. |||..|||. |.|  . .|| |..  .|  | |||| .|.     ... .||.| ||  || 
rakilekkleegkvfteyeripkkre...dallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvq

DFWRMLSEQDSACVVLFQPT-EEGD--FPQFWPEVGKetyDMISVECSDERSSsvDnlRASYDQSEIAQLRFNVKDLRTPENlHKIKMFVVSGWTSEDET
|||.|. ||. . .|.   . |.|     ...|. ..      .||    . .     . | | . ..   ...| | . |.  .. ..    |. ..  
dfWqmvWeqgvqlivmlteeeedgkeksfkyfPkles...kkktvefgkfkvt..t..kfsedsdsvittglklkhlpskee.rtvwhlqytDWpdhgvP

PPTSSIITLIAKVERWQ---Q-----QSGNGPITVVCSDGIGRSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYL
.  .. .  . .|.  .   .     .. . |. | ||.|.||.|       ... .. ...||. .... .|  |  ||.| | |||.. .. .||
eDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 5-147 1.9e-29 97.3 In-house 87-230 (440) alignment 
Range on Protein: 5-147
Range on HMM: 87-230/440.0
EEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRA-YNPPDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYTFC
| | .||.|.  |||.|||..   .| . . |    .    ||...|||||.||.|  |..|..|  ..    .|||...  .|  |  |||| |||.| 
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

HDAVLEAIQCGNTQILAHDLRITLSRMEDVDKELKMTRFDSEFK
|.||||.. ||.| ||  |.   . ...  .     . .. ||.
heavlegllcgdtliledditerveqiqwpnphtdksplqqefe
subfamily_CG7180_pd Subfamily CG7180 3-116 2.2e-29 97.0 In-house 176-295 (296) alignment 
Range on Protein: 3-116
Range on HMM: 176-295/296.0
EKEEREVKQFHFTVWPD-HGVPEYPTAILAFRRRVRAYN-----PPDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQT
. |.| ||.|..|.|.  . ||   .|.. .||||| .       |. |||....| |..||| .. ||| |. |. |  .|.|..|  ||  |  .|..
kaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLven

EEQYTFCHDAVLEAIQCGNT
 |.| .. | .|||. |. .
veeYkyiYdvlleavlcnkd
subfamily_PTPN3_pd Subfamily PTPN3 3-111 2.9e-29 96.9 In-house 167-275 (280) alignment 
Range on Protein: 3-111
Range on HMM: 167-275/280.0
EKEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNPPDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYTF
.||||.. |. .. |||||||. .. .| | .|||..   .  ||..|||||.||.| .|...  |  ..|. .. . . |  .| .|...|||..||.|
tkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykf

CHDAVLEAI
  .|.|.. 
vCeailkvy
0043147 (Phosphotyrosine protein) phosphatases II 195-411 6.8e-29 96.2 In-house 3-160 (172) alignment 
Range on Protein: 195-411
Range on HMM: 3-160/172.0
EITTYINAVHISGYKQQHAFIVTQYPLTATVSDFWRMLSEQDSACVVLFQPTeegdfpqfwpevgketydmisvecsdersssvdnlrasydqseiaqlr
| ..|||| ....|   . ||.||.||  |..|||||| |..  ..|   .                                                 
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel................................................

fnvkdLRTPENLHKIKMFVVSGWTSEDETPPTSSIITLIAKVERWQQQSGNGPITVVCSDGIGRSGTFSALYSVLervkieQVIDVLQAIKAMRIPRPGL
     | .||.|..  . .         .|... .. ..  .......| .||. | || |.||.||. |.| .|      . .....|.. .|  ||| 
.....lydpellerlgiqylylpwpDhgvpllellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpga

VKTTAEYKFIHYAVQEY
| .   |.|..|  . .
vqnpsqyrflyyfekll
0043147 (Phosphotyrosine protein) phosphatases II 3-104 1e-28 95.6 In-house 59-154 (172) alignment 
Range on Protein: 3-104
Range on HMM: 59-154/172.0
EKEEREVKQFHFTVWPDHGVPeYPTAILAFRRRVRA-YNPPDAGPVIIHCSAGVGRSGTFIVIDAMLdrvnaeSSLDIFNYVAYLRTRRTAMVQTEEQYT
|..||.. |.... |||||||  .  .| | . ..  ..  . |||..||||||||.||..... ||       .|.... ||..|..|  .||...|| 
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyr

FCH
|..
fly
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 4-116 3.9e-28 93.1 In-house 175-288 (290) alignment 
Range on Protein: 4-116
Range on HMM: 175-288/290.0
KEEREVKQFHFTVWPDHG-VPEYPTAILAFRRRVRAYNPPDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYTF
.....|.|...| |...| |... | .|.......    .  .....|||..||||..|....  ..... |   |.|. .  .|. .  .|||..|| .
gakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqg

CHDAVLEAIQCGNT
 .. ||..... .|
ifqivltyldsfet
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 147-414 4.6e-28 92.7 In-house 32-285 (290) alignment 
Range on Protein: 147-414
Range on HMM: 32-285/290.0
KTLNKVSPILPKACYIVASYPENK--DKNRYSDILASDFSRVVLTaidDNEITTYINAVHISGYKQqhAFIVTQYPLTATVSDFWRMLSEQDSACVV-LF
. |.|. | ||   .    . .|    |||| |.   | .||.|    |     |. | .. | |    ||.|| .|..|| |.|||. ... | .| | 
eyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilk...dGydGdyvhanyvkGlka..mfiltqGalkdtvidiwrmvlqekvaaivmlc

QPTEEGD--FPQFWPEVGKE--TYDMISVECSDERSSsvDNlrasydqsEIAQLRFNVKDLRTPENlHKIKMFVVSGWTseDETPPTSSIiTLIAKVERW
.  |.|     |..||   |  |.  |.| || | .   |.        .| .  . |.|  .  . ||.| . .  |   | . . |.. .|.  .   
eliedGkakceqyypekeGevltfGeitvlcseeddk..da........niikktlsvrdkdsGke.hklkhlkikswp..dksvalstl.allrtlril

QQQsgNGPITVVCSDGIGRSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYLAA
..   .||..| || ||||.||| |.   |. .   . .|.|. ..|.|  | . |.   .|  .  .. ..  .
rka..sGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGkd
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 4-109 3.1e-27 90.3 In-house 158-266 (274) alignment 
Range on Protein: 4-109
Range on HMM: 158-266/274.0
KEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAY---NPPDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQY
..||.|| . .| |||| .|. ....| . . |.     .   ..||..|||||.|| | || |.  . ....|. .|... |. ||  |  ||||.|||
erersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqy

TFCHDAVLE
 . | |. .
elihralcl
0048076 (Phosphotyrosine protein) phosphatases II 3-108 3.5e-27 90.2 In-house 41-140 (145) alignment 
Range on Protein: 3-108
Range on HMM: 41-140/145.0
EKEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNPPDaGPVIIHCSAGVGRSGTFIVIDAMLDrvnaeSSLDIFNYVAYLRTRRTAMVQTEEQYTF
| .||.. |.... |||||||. .  .|.| . .... . . |||..||||||||.||..... ||       ...... ....|..|  .|....|. |
ellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgqlrf

CHDAVL
.....|
lyefel
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 169-410 4e-27 89.9 In-house 7-238 (239) alignment 
Range on Protein: 169-410
Range on HMM: 7-238/239.0
NKDKNRYSDILASDFSRVVLTAIDDNEITTYINAVHISGYKQ-QHAFIVTQYPLTATVSDFWRMLSEQDSACVVLFQPTEEGD---FPQFWPEVGKeTYD
|| ||||..|.. |.|||||  . ..  . |||| ..  |    .|.| ||  ....  |||||. ..  . .|..    ||      |.||.     | 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.kyc

MISVECSDERsSSVDNLRASYDQSEIAQlrfnvkdlrTPENlhKIKMFVVSGWTSEDETPPTSSIITLIAKVERwQQQSGNGPITVVCSDGIGRSGTFSA
 . |          | .  ..  |.. |         | |    .  . .. |  .     ..... |  |. . .   |  |  . || |.||.|.|  
nlrvtlrkte.vfadyiirtfvmsqvgq.........teer..yvyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflv

LYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQE
. ..| . | .. .|... .||.|  || .|.|. .| ||| || |
idamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_PTPRN_pd Subfamily PTPRN 4-111 4.2e-27 89.6 In-house 184-292 (297) alignment 
Range on Protein: 4-111
Range on HMM: 184-292/297.0
KEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNPPDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNA-ESSLDIFNYVAYLRTRRTAMVQTEEQYTF
.| | | ||||  ||..|||  . ..| |||.|       . |...|||.|.||.|..|.|| .|.|..     .||   . .|| .|. .|.|..|. |
setrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfef

CHDAVLEAI
.  || | .
altavaeev
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 169-410 5.1e-27 89.6 In-house 8-239 (239) alignment 
Range on Protein: 169-410
Range on HMM: 8-239/239.0
NKDKNRYSDILASDFSRVVLTAIDDNEITTYINAVHISGYKQ-QHAFIVTQYPLTATVSDFWRMLSEQDSACVVLFQPTEEGD---FPQFWPEVGKeTYD
|| ||||..|.. |.|||||  . ..  . |||| ..  |    .|.| ||  ....  |||||. ..  . .|..    ||      |.||.     | 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.kyc

MISVECSDERsSSVDNLRASYDQSEIAQlrfnvkdlrTPENlhKIKMFVVSGWTSEDETPPTSSIITLIAKVERwQQQSGNGPITVVCSDGIGRSGTFSA
 . |          | .  ..  |.. |         | |    .  . .. |  .     ..... |  |. . .   |  |  . || |.||.|.|  
nlrvtlrkte.vfadyiirtfvmsqvgq.........teer..yvyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflv

LYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQE
. ..| . | .. .|... .||.|  || .|.|. .| ||| || |
idamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
0046846 (Phosphotyrosine protein) phosphatases II 189-412 5.1e-27 90.2 In-house 4-173 (176) alignment 
Range on Protein: 189-412
Range on HMM: 4-173/176.0
TAIDDNEITTYINAVHISGYKqqhaFIVTQYPLTATVSDFWRMLSEQDSACVVLFQPTEEGDF---PQFWPEVGKETYdmisvecsdersssvdnlrasy
. . ...  .||||  | |..    .|.||.||  |. ||..|| |..  .|| ..   | ..   |..|||. |. .                      
rllgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi......................

dqseiaqlrfnvkdlrtpenlhkikMFVVSGWTSEdETPPTSSIITLIAKVERWQQQSgnGPITVVCSDGIGRSGTFSALYsvleRVKIEQVIDVLQAIK
                          . . .|     .|. . ...|.. .......   ||. | || ||||.||. |.|     .. |. ..|..|..
.........................qylhlpwpDh.gvpdlelllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveeala

AMRIPRP-GLVKTTAEYKFIHYAVQEYL
 .|  || | | | . |.|........|
lvreqRplgavqtpeQyrflyefellll
0048179 (Phosphotyrosine protein) phosphatases II 3-105 5.2e-27 89.7 In-house 43-139 (144) alignment 
Range on Protein: 3-105
Range on HMM: 43-139/144.0
EKEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNPPDaGPVIIHCSAGVGRSGTFIVIDAMLdrvnaESSLDIFNYVAYLRTRRTAMVQTEEQYTF
| .|||. |.... |||||||.... .|.| . .... ... |||..||||||||.||..... |.     .  |.... .|..|.||  .|....|. |
efleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpgqlrf

CHD
...
Lle
0049260 (Phosphotyrosine protein) phosphatases II 11-105 1.4e-26 88.4 In-house 56-144 (152) alignment 
Range on Protein: 11-105
Range on HMM: 56-144/152.0
QFHFTVWPDHGVPEYPTAILAFRRRVRAYNPPDAGPVIIHCSAGVGRSGTFIVIDAMLdrvnaeSSLDIFNYVAYLRTRRTAMVQTEEQYTFCHD
|.... |||||||. .  .| . . .. ..  . |||..||||||||.||..... ||        ......||..|..|  .|....|. |...
qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 4-112 5e-26 86.3 In-house 149-265 (270) alignment 
Range on Protein: 4-112
Range on HMM: 149-265/270.0
KEEREVKQFHFTVWPDHGVPEYPT------AILAFRRRVRAYNPP--DAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQ
 |||..  |... |||||||. .        .|.  | ||...    .|.|...||||||||.||.|..| ..  .. ....|. . .. ||  |.|.||
geerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvq

TEEQYTFCHDAVLEAIQ
. |||.| . ||.| ..
hpeqyeflykavveyae
0046846 (Phosphotyrosine protein) phosphatases II 10-109 9.9e-26 86.0 In-house 77-171 (176) alignment 
Range on Protein: 10-109
Range on HMM: 77-171/176.0
KQFHFTVWPDHGVPEYpTAILAFRRRVRAYNPPDaGPVIIHCSAGVGRSGTFIVIDAMLDrvnaESSLDIFNYVAYLRTRRT-AMVQTEEQYTFCHDAVL
 |.... |||||||.. ...| . . .| .   . |||..|||||.||.||..... .      |  |.... .|..| .|   .|||.||| |.....|
iqylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpeQyrflyefel

E
.
l
0049260 (Phosphotyrosine protein) phosphatases II 205-406 1.5e-25 85.1 In-house 2-144 (152) alignment 
Range on Protein: 205-406
Range on HMM: 2-144/152.0
ISGYKQQHAFIVTQYPLTATVSDFWRMLSEQDSACVVLFQPTEEGDFPQFWPEVgketydmisvecsdersssvdnlrasydqseiaqlrfnvkdlrtpe
|.||.....|| ||.|.  |..|||||| |..  ..|     .| ......                                                 
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..............................................

nlhkikmfVVSGWTSEDETPPTSSIITLIAKVERWQ-QQSGNGPITVVCSDGIGRSGTFSALYSVLervkieQVIDVLQAIKAMRIPRPGLVKTTAEYKF
         .  .  .| ..|..|.. |..     . ... .||. | || |.||.||. |.| .|      . .....|.. .|  ||| | .   ..|
........qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrf

IHY
...
lye
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 3-116 3.1e-25 83.5 In-house 184-298 (301) alignment 
Range on Protein: 3-116
Range on HMM: 184-298/301.0
EKEEREVKQFHFTVWPDHGV-PEYPTAILAFRRRVRAYNPPDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYT
.|. ..| |.. | ||..|| .|. | . .    . . . .. |||..|||..|.|||... ..  |. . ||   |.|. .  .|  .  .|.| ||||
dksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqyt

FCHDAVLEAIQCGNT
. .|.. . .|. .|
siydvidmylqlnst
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 167-409 3.8e-25 83.5 In-house 1-236 (237) alignment 
Range on Protein: 167-409
Range on HMM: 1-236/237.0
PENKDKNRYSDILASDFSRVVLTAIDDNeiTTYINAVHISGYKQ-QHAFIVTQYPLTATVSDFWRMLSEQDSACVVLFQPTEEG---DFPQFWPEVGK-E
.||| ||||..| | | |||||     .  . |||| .. |.    . .| .| || ..  |||.|. ..  . .|..    ||      ..||.  . .
senkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpa

TYDMISVECSDERSSSVDNLRaSYDQSEIAQLRfnvkdlrtpeNLHKIKMFVVSGWTSEDETPPTSSIITLIAKV-ERWQQQSGNGPITVVCSDGIGRSG
.| ...|    .   |   .| |.  |.  .|.          ..  |. .  . |        |.... .  .. .| .  |  ||  . || |.||.|
aygvltvslkkkeefsdytvr.slllskrltlk..........evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtg

TFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQ
 |  . ..| . | ..|.|. . ....   || ...|  .| ||| .. 
iflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 42-127 2.2e-24 80.9 In-house 197-282 (283) alignment 
Range on Protein: 42-127
Range on HMM: 197-282/283.0
PDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYTFCHDAVLEAIQCGNTQILAHDLRITL
   ||...|||.|.||...|| . | .. . .|| .|.|. |  .| .|  .||| .|| . |..|||   ||.||| | ||  | 
skkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdlqsti
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 141-412 2.2e-24 81.0 In-house 17-277 (307) alignment 
Range on Protein: 141-412
Range on HMM: 17-277/307.0
RFDSEFKTLNKVSPilpkACYIVASYPENKDKNRYSDILASDFSRVVLTAidDNEITTYINAVHISGYKQQHAFIVTQYPLTATVSDFWRMLSEQDSACV
..  ||. | | .|        | ..  | |||||.|. . | .|.|..   |   . || | ..    . . ||..| || .|. .|| |  ...  .|
alvdefrvlakktp....egvtveafsantdknryqdvkcqdkgrivvkf..dglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesv

VLF-QPTEEGD--FPQFWPEVGKETYdmisVECSDERSSSVDNLRASYDQSEIAQLRFNVKDLRTPENLHKIKMFVVSGWTSEDETPPTSSIITLIAKVE
... .  | .     |.|| .  ..     | ..  .. ||.|| |     .   .     ..   ..   |. .  . |  .   .   . | |.  |.
imlckvielakikceqywpleegqkl....vfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavr

rwqqqSGNGPITVVCSDGIGRSGTFSALYSVLER-VKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYL
       . |. | || |.|||||  |.  | .. .. .   |. . .. .|  |.  ..| |.| ..|  . ||.
.....ydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
PTPc_DSPc_SM00012 309-409 1e-23 78.9 In-house 2-104 (105) alignment 
Range on Protein: 309-409
Range on HMM: 2-104/105.0
IKMFVVSGWTSEdETP-PTSSIITLIAKVERWQQQSG-NGPITVVCSDGIGRSGTFSALYSVLERVKIE-QVIDVLQAIKAMRIPRPGLVKTTAEYKFIH
.| . ..||. . ..| ...||..|...|......|. ..|. |.||.|.||.||| ||. .|.... | . .|..| .|..|  |||.|.| ..| |..
vkhyhytgwpdh.gvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

YAVQ
 |..
rall
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 164-408 1.4e-23 77.9 In-house 47-286 (310) alignment 
Range on Protein: 164-408
Range on HMM: 47-286/310.0
ASYPENKDKNRYSDILASDFSRVVLTaIDDNEITTYINAVHISGYKQQHAFIVTQYPLTATVSDFWRMLSEQDSACVVLFQPTEEGDFPQ---FWPEVG-
 .| ..  ||||||..  | ||| |. ||      || | ..     . .||..| ||  |. |||||. .. .  ..|.  . |   |.   .|| .| 
eaykkymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgv

KETYDMISVECSDERSSSVDNLrasydQSEIAQLRFNVKDLRTPENLHKIKMFVVSGWTSEDETPPTSSIITLIakvERWQQQSGNGPITVVCSDGIGRS
 |||  | |    | |   .       .  .. .  ||     | ||..... ..      |   |     |.    .|   |   ||  | || |..| 
tetygcirvtnlsesseefeic.....nlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp...qrllaqvrhgpcvvhcsagkdrl

GTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAV
..  ||   .....  . .|. . .  ..  |   ..|  .| .|..  
yvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvr
subfamily_PTPN23_pd Subfamily PTPN23 4-112 3e-23 77.1 In-house 168-281 (288) alignment 
Range on Protein: 4-112
Range on HMM: 168-281/288.0
KEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRA-Y---NPPDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSL-DIFNYVAYLRTRRTAMVQTEE
.. ..|.  ..| ||..|||. |  .|.|   |.. |   . .   |...||||||||.|.| .. | .  ....  | || . |  ||. |  |||..|
davksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqeke

QYTFCHDAVLEAIQ
|. |. .|||||..
qlkfsyeavleaar
0051082 (Phosphotyrosine protein) phosphatases II 196-408 3e-23 77.5 In-house 2-149 (151) alignment 
Range on Protein: 196-408
Range on HMM: 2-149/151.0
ITTYINAVHISGYkqqhaFIVTQYPLTatvsDFWRMLSEQDSACVVLFQPTE-EGDFPQFWPEVGketydmisvecsdersssvdnlrasydqseiaqlr
...|||.  . |.     ......||     ||...| |..  ..| . ..|  | .|...|| |                                   
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeergycpeylpelg...................................

fnvkdlrtpenlHKIKMFVVSGWTSEDetppTSSIITLIAKVERWQQQSGNGPITVVCSDGIGRSGTFSALYSVLERvkieqvIDVLQAIKAMRIPRPGL
            .... . . .|.  .    .. ..  .... .. .. .|||. | || |.||.||. ||| .|..      ... .|.. .|. |||.
............ievlhipildwpdpg....lplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgv

VKTTAEYKFIHYAV
| .  .. |...|.
vqpnqqflfqlfal
0051082 (Phosphotyrosine protein) phosphatases II 4-108 6.2e-23 76.5 In-house 55-150 (151) alignment 
Range on Protein: 4-108
Range on HMM: 55-150/151.0
KEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAynpPDAGPVIIHCSAGVGRSGTFIVIDAMLDRvnaessLDIFNYVAYLRTRRTAMVQTEEQYTFC
....||...... |||.|.|... |.|.| . ...   .. |||..|||||.||.||..... || .      ....  ....| .|. .||...|. |.
elgievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfq

HDAVL
. |.|
lfall
0044763 (Phosphotyrosine protein) phosphatases II 182-411 7e-23 76.6 In-house 3-170 (178) alignment 
Range on Protein: 182-411
Range on HMM: 3-170/178.0
DFSRVVLTAIDDNEITTYINAVHISGYkqqhaFIVTQYPLtatvSDFWRMLSEQDSACVVLFQPTEEGD----FPQFWPEVGketydmisvecsdersss
|..||.|. . . | . ||||..| ..     ......|     .|....| |..  ..| . .. |.     .|... | |                  
drtrvllsnleglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag..................

vdnlrasydqseiaqlrfnvkdlrtpenlhkikmFVVSGWTSEDETPP--TSSIITLIAKVERWQQqSGNGPITVVCSDGIGRSGTFSALYSVLERvkie
                                  . .  .  .| ..|  .. .  ... .|.... . .||. | || |.|||||. |.| ....    
..................................iqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl....

QViDVLQAIKAMRIPRPgLVKTTAEYKFIHYAVQEY
.. .. .||. .|  ||  | .   ......  ...
gl.sleeaielvrerRp.ivpnpgqlrqLyefelrl
subfamily_PTPN14_pd Subfamily PTPN14 4-112 7.8e-23 75.9 In-house 180-297 (300) alignment 
Range on Protein: 4-112
Range on HMM: 180-297/300.0
KEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRA-------YNP--PDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMV
||||.|  . .| |||||||| ..  | . ..|..        ..      ||..||||||||.|  |. | ..  .. . ..|| . .| ||..|  .|
keertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllv

QTEEQYTFCHDAVLEAIQ
||  ||.| ...... ..
qtlaqYkfvYkvlikylk
0044763 (Phosphotyrosine protein) phosphatases II 10-109 1.2e-22 75.8 In-house 76-169 (178) alignment 
Range on Protein: 10-109
Range on HMM: 76-169/178.0
KQFHFTVWPDHGVPEYPTAILAFRRRVRAYNPPDAGPVIIHCSAGVGRSGTFIVIDAMLDRvnaesSLDIFNYVAYLRTRRTaMVQTEEQYTFCHDAVLE
 |.... .||||||. .  .|.| . .... ... |||..|||||||||||..... |. .     .|.... ....| ||  .|....|. ....  |.
iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpgqlrqLyefelr
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 45-110 4.5e-22 73.3 In-house 193-258 (267) alignment 
Range on Protein: 45-110
Range on HMM: 193-258/267.0
GPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYTFCHDAVLEA
 |....||.||||||||.|||..|.|.  |. .|||...  .| .| ..|.| |.| ..|. . | 
rPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
subfamily_ptpA1_pd Subfamily ptpA1 168-383 6.6e-22 72.8 In-house 46-265 (418) alignment 
Range on Protein: 168-383
Range on HMM: 46-265/418.0
ENKDKNRYSDILASDFSRVVLTAIDDNEITTYINAVHISGYKQqHAFIVTQYPLTATVSDFWRMLSEQDSACVVLFQPTEE-G--DFPQFWPE-VGKETY
 |  ||||..||  ...|| |  |.|.| . |||| .| |    . ||.|| ||  |..|||||. |.    .|..    |       ..||| .| | .
hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqf

DMISVECSDERSSSVDNLRASYDqSEIAQLRFNVKdLRTPENLHKIKMFVVSGWTSEDETPPTSSIITLIAKVERWQQQ-----SGNGPITVVCSDGIGR
 .         . ||. .    |  |   .  |.. |    . . |  .   ||   .    |  .  |.  .   |.|       | || | || |.||
siygngnevfgtysvelveviqd.pereiitrnir.ltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgr

SGTFSALysVLERVKIEQVIDVLQA
.||| .   |.   |... .  |.|
tgtfcta..vimmkkldhyfkqlda
0049772 (Phosphotyrosine protein) phosphatases II 3-113 2.6e-21 72.1 In-house 174-282 (314) alignment 
Range on Protein: 3-113
Range on HMM: 174-282/314.0
EKEEREVKQFHFTVWPDHGVPeYPTAILAFRRRVRAYnpPDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNaessLDIFNYVAYLRTRRT-----AMVQTE
|. ||.. ... . .||...|  .  ...| . ....  .. |||..||.||.||.|||.|.. .. . .    ...   ....| .|.      .... 
elferlgikylripvpDgsap.lledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieql

EQYTFCHDAVLEAIQC
||| |...|.||... 
eqyefilealleylkf
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 160-413 2.6e-21 70.9 In-house 34-272 (288) alignment 
Range on Protein: 160-413
Range on HMM: 34-272/288.0
CYIVASYPENKDKNRYSDILASDFSRVVLTaiDDNEIttYINAVHISGYKQQHAFIVTQYPLTATVSDFWRMLSEQDSACVV-LFQPTEEGD--FPQFWP
  |. |. .|  ..|| ..   |..|| |.  || .   ||.|  .|  | .. .| .| || .|.  .|.|| |.|   .| | .  | |     ...|
idiidsfianptrdryenlprcditrvkls..ddpdf..yiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfP

EVGKETYDmISVECSDERSSSvdnlrASYDQSEIAQLrfnVKDLRTPENLHKIKMFVVSGWTSEDETPPTSSIITLIAKVerwqqQSGNGPITVVCSDGI
 .  |.   |   |.. . .      |  |.     |   ..  .. |.   .|.  .  |  .       | . |.  .     .| . || | .| |.
sklGekar.igrlctvvkkkr.....adidklvkvsl...lriskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGv

GRSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYLA
||.||.     .|| ....  . . . .. .|  |   ..|   | ..|  | |.|.
Grtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleell
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 167-409 4.2e-21 70.1 In-house 31-292 (297) alignment 
Range on Protein: 167-409
Range on HMM: 31-292/297.0
PENKDKNRYSDILASDFSRVVLTAIDDNeiTTYINAVHISGYKQQH--AFIVTQYPLTATVSDFWRMLSEQDSACVVLFQPTEEGD---FPQFWPEVGKE
.    |||| |||| | .|| |     .  . |||| ..   ....   .|..| || ||| |||... |||   .|.    .|.       .||.| .|
nsslrknryrdilatddtrvkllrvite..rdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqe

TYDM--ISVEC----SDER-SSSVDNLRASYD--QSEIAQLRF-NVKDLRTPENLHKIKMFVVSGWTSEDETPPTSSIIT-----LIAKVERWQQQ-SGN
      . ||     |||     . .|.  |   .  .   .| .  |   | .|. .. | .   .     |   ...      .. ..|  . .   |
rlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraemprn

GPITVVCSDGIGRSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQ
 .. | || |.||||       .|.... ... ||   .. .|  |. ||.|  ...... || 
ayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavl
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 48-114 1.3e-20 67.5 In-house 2-68 (69) alignment 
Range on Protein: 48-114
Range on HMM: 2-68/69.0
IIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYTFCHDAVLEAIQCG
..|||.| ||.|||| |   . |. .|  .|||| | |.|  |  ||  | .| | |||. ||.. |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 48-114 2.5e-20 66.6 In-house 1-67 (69) alignment 
Range on Protein: 48-114
Range on HMM: 1-67/69.0
IIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYTFCHDAVLEAIQCG
..|||.| ||.|||| |   . |. .|  .|||| | |.|  |  ||  |..| | |||. ||.. |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 150-412 6.7e-20 66.2 In-house 17-270 (285) alignment 
Range on Protein: 150-412
Range on HMM: 17-270/285.0
NKVSPILPKACYIvASYPENKDKNRYSDILASDFSRVVLTAIDDNEITTyiNAVHISGyKQQHAFIVTQYPLTATVSDFWRMLSEQDSACVVLFQPTEEG
.|.   .|  |   ..|  | | |||.|. . . .||||   | . | .  . ... | |.| ..| || ||  |.||||.|. ..  | |...    ||
dkikgymppncty.tayeanpdlnryadvrcieetrvvlknhdrdyiha..swmrmpg.kdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeg

DFP---QFWPE----VGK-ETYDMISVECSDERSSSVdnLrasYDqseiAQLRFNVKDlRTPENLHKIKMfVVSGWTSEDETPPTSSIITLIAKVERWQQ
       ..||    | |   |..   || .|  .    .   ..    |    | .|  . | |.  ..  |  |  .     .  .| |   |.. . 
gvekcalyypeklgevvkfgkyeitlteckeeaiagt..i...ln....altvinted.asseplymnhv.qvpwwpdqlapedarpmielykwvkkvnp

QsgNGPITVVCSDGIGRSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYL
.  . || | || |.||. ||  .     |.  .  |..|. .. ||  |   |..  .. |..  . ||.
k..ekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 4-110 8.4e-20 65.7 In-house 183-286 (305) alignment 
Range on Protein: 4-110
Range on HMM: 183-286/305.0
KEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRaynpPDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFN-YVAYLRTRRTAMVQTEEQYTF
.. | |...|.  ||| |||   .||| .  . |    |  ||...|||||.||.|. .... .||.. |   ..  .  .  .| .|   .||..|| |
ekarkvthyhwidwpdrgvpaadlailellekar....pskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylf

CHDAVLEA
 |. .|. 
vhqvilny
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 142-412 1.1e-19 65.3 In-house 26-289 (305) alignment 
Range on Protein: 142-412
Range on HMM: 26-289/305.0
FDSEFKTLNKV-SPILPKACYIVASYPE-NKDKNRYSDILASDFSRVVLtaiDDNEITTYINAVHISG-YKQQHAFIVTQYPLTATVSDFWRMLSEQDSA
.  ||. | |   | . .. .     .. .. ||||.|. . | | | |   |.   . || | ..      .. ||..| ||  |. .|| |. ..   
lreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkl...dkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkve

CVV-LFQPTEEGDF--PQFWPEVGKETYDMISVECSDERSSSVDNLRASYDQSEIAQLRFNvkdlrtPENLHKIKMFVVSGWTSEDETPPTSSIITLIAK
 .| | .  | | .   |.||    |  .. |    .. | |    | .  |  . .| ..       ..   .. .  . |      |   . . |.. 
qivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltys......gdqkmsvrhlqwtewpdrgvppckltslellsa

VerwqqQSGNGPITVVCSDGIGRSGTFSALYSVLERVKIE-QVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYL
.     .  . || | || ||||.||  |.  .||..  . ..  . . .||.|  |   ...  .| |||  . .|.
i.....rgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 139-415 1.8e-19 64.4 In-house 10-272 (281) alignment 
Range on Protein: 139-415
Range on HMM: 10-272/281.0
MTRFDSEFKTLNKVSPilpKACYIVASYPENKDKNRYSDILASDFSRVVLTA-IDDNEITTYINAVHISGYKQQHAFIVTQYPLTATVSDFWRMLSEQDS
.  |  ||  |    |        |   | |. ||||..| . | ||| |   . ... | || | .|     .. .|.|| |   | .|||||. ....
lddfkqefsnlpgdpp...sdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqent

AC-VVLFQPTEEGdfpqfwPEVGKETYDMISVECSDersssVDNLRASYDQSEIAQLRFN-VKDLRTPENLHKIKMFVVSGWTseDETPPTSSIITLiaK
.. |.| | .|         |   | .   .  | .     .|.|  ||..| . .       .|    . . |  ..   |   |   | || . |  |
taivmlcqfletn......rekcaeyfprnahcclq.....fdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewp..dwqvpessevml..k

VERWQQqSGNGPITVVCSDGIGRSGTFSALYSVLERVKIEQ-VIDVLQAIKAMRI-PRPGLVKTTAEYKFIHYAVQEYLAAF
. |  . .   |  . || |.|||||. |.   |. ..    . |. | .  .|.  |   |.|  .| .|   . ..  |.
ilrkir.arstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgvay
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 4-109 4.8e-19 63.5 In-house 173-275 (307) alignment 
Range on Protein: 4-109
Range on HMM: 173-275/307.0
KEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAynppDAGPVIIHCSAGVGRSGTFIVIDAMLDRV-NAESSLDIFNYVAYLRTRRTAMVQTEEQYTF
.. | .... .. |||.|||.   . . .   ||     |  ||..||||||||||| . |  . |.. . .   |. . |  ||..|   .||| || .
qksrtiqhlqwenwpdrgvpqinltainlleavry....dtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqyly

CHDAVLE
 |  .||
lhrvlle
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 3-109 6.9e-19 62.7 In-house 163-275 (287) alignment 
Range on Protein: 3-109
Range on HMM: 163-275/287.0
EKEE-REVKQFHFTVWPDHGVPEYPTAILAFRRRV-----RAYNPPDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQT
| .| | |||...  |||....    ... |   |      | .  ..||...|...|.||||... . ....| .    .|. . |..|| .|.|.||.
etrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqa

EEQYTFCHDAVLE
  |. .  .|.  
vvqlrllyealvt
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 5-111 3.4e-18 60.7 In-house 168-271 (288) alignment 
Range on Protein: 5-111
Range on HMM: 168-271/288.0
EERE-VKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNppdaGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYTFC
||.  ||. |.  |.|.||||   . | .  ......     |...|.||||||.||.|.|  .|. .  .  | | . .| ||  |   .||| || . 
eekvivkilhlleWdddgvPenylsplrllevlkslq....kPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyv

HDAVLEAI
|  ||| .
hrcvleel
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 169-412 3.4e-18 60.4 In-house 48-287 (305) alignment 
Range on Protein: 169-412
Range on HMM: 48-287/305.0
NKDKNRYSDILASDFSRVVLtaiDDNEITTYINAVHISGYKQQHAFIVTQYPLTATVSDFWRMLS-EQDSACVVLFQPTEEGDFPqFWPEVGKETYDMIS
...|||| |.   |  || |   .      || | ..|   . . || || ||  | .||| |   ..  |  .| .  | |           .  |...
eagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakk.cleyfaskdkdvle

VECSDERSSS-VD-NLRASYDQSEIAQLRFNVKDLRTP-ENLHKIKMFVVSGWTSEDETPPTSSIITLIAKVerwqqQSGNGPITVVCSDGIGRSGTFSA
 |  ... |  ..   . .. ..  |...  |  .  | |. .|.. .    |      .   .|. |..|      ..  |||.| || ||||.|.   
feekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelleka.....rpskgpivvhcsagigrtgsvvm

LYSVLERVKIEQVIDVLQ-AIKAMRIPRPGLVKTTAEYKFIHYAVQEYL
|  .|...   |.|.  .  .. .|  |   ..| |.| |.|  . .|.
leyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 6-109 3.9e-18 60.1 In-house 182-281 (290) alignment 
Range on Protein: 6-109
Range on HMM: 182-281/290.0
EREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYnppdAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYTFCHD
|  .| ..   |||. |.    |.|   | .|      .|||..|||||.||.|||. |.. |. .    .||. . |  ||  | . || . ||    .
ehklkhlkikswpdksvalstlallrtlrilrka....sGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalve

AVLE
..|.
illd
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 169-397 5.5e-18 59.7 In-house 50-266 (301) alignment 
Range on Protein: 169-397
Range on HMM: 50-266/301.0
NKDKNRYSDIlASDFSRVVLTAIDDNEITTYINAVHISGykQQHAFIVTQYPLTATVSDFWRMLSEQDSACVVLFQPTEEGDFPQFWPEVGKETYDMISV
.|||.||  .   . |  |    | . .  . | .  ||  . | ||.|| ||..|  ||| ||   |   .|..  . |    .    .  .. . . .
pkdkhryptv.PckPstavevivdGkrvPihanwiptsG..hphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldi

ECSDERSSSVDNLrasyDQSEIAQLRFNVKDLRTPENLHKIKMFVVSGWTSEDETPPTSSIITLIAKVERwqqqSgNGPITVVCSDGIGRSGTFSALYSV
.  . .  . . .     . .| . ...|.|     . . .  .  | || ..       .  |.  | .    | . || | ||.||||| .| .   .
grfkikiknkeli....lnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkk....s.ekPivvhcsaGiGrsvafigteyl

LERVKIEQVIDVLQAIKAMRIPRPGLVKT
  .|. .. |.. .|.| .|  |   |.|
areveadptieltealkhlrehrwngvqt
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 308-415 1.1e-16 55.2 In-house 90-197 (440) alignment 
Range on Protein: 308-415
Range on HMM: 90-197/440.0
KIKMFVVSGWTSEDETPPTSSIITLIAKVERWQQQSGNGPITVVCSDGIGRSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYA
 .| .   ||  .     .. .. .|  |.  |...||||. | || | ||.|   |. |.|  .|  . ||..  |..||  || .|.|  .| |.| |
tlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvhea

VQEYLAAF
| | | . 
vlegllcg
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 209-405 1.2e-16 55.5 In-house 2-197 (199) alignment 
Range on Protein: 209-405
Range on HMM: 2-197/199.0
KQQHAFIVTQYPLTATVSDFWRMLSEQDSACVVLF---QPTEEGDFPQFWPEVGKETYDMISVECSdersssVDNLRASYDQSeIAQLRFnVKDLRTPEN
| |. .|.||.||  |..|||.|. |  |  .|.    |   | |.| .|| .   |  . |.  .      .  . .  | . |. | . ...  .|  
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvt......tktittkpdyt.italil.tnnttapps

LHKIKMFVVSGWTsEDETPPTSSIITLIA---KVERWQQQSGNGPITVVCSDGIGRSGTFSALYSVL---ERVKiEQVIDVLQAIKAMRIPRPGLVKTTA
  .|  .  . |  |  ||  . .. ..    .| .  .|  . |. | |||| | .| | ||   .   |  |   |.|...  | .|  | |.. .  
treishyqftswk.ekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslq

EYKFIH
 |.||.
hynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 209-405 1.9e-16 54.8 In-house 1-196 (198) alignment 
Range on Protein: 209-405
Range on HMM: 1-196/198.0
KQQHAFIVTQYPLTATVSDFWRMLSEQDSACVVLF---QPTEEGDFPQFWPEVGKETYDMISVECSdersssVDNLRASYDQSeIAQLRFnVKDLRTPEN
| |. .|.||.||  |..|||.|. |  |  .|.    |   | |.| .|| .   |  . |.  .      .  . .  | . |. | . ...  .|  
kgqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvt......tktittkpdyt.italil.tnnttapps

LHKIKMFVVSGWTsEDETPPTSSIITLIA---KVERWQQQSGNGPITVVCSDGIGRSGTFSALYSVL---ERVKiEQVIDVLQAIKAMRIPRPGLVKTTA
  .|  .  . |  |  ||  . .. ..    .| .  .|  . |. | |||| | .| | ||   .   |  |   |.|...  | .|  | |.. .  
treishyqftswk.ekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslq

EYKFIH
 |.||.
hynfiy
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 3-109 2.4e-16 54.2 In-house 163-267 (281) alignment 
Range on Protein: 3-109
Range on HMM: 163-267/281.0
EKEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNPPdagpVIIHCSAGVGRSGTFIVIDAMLDRVNAESSL-DIFNYVAYLR-TRRTAMVQTEEQY
| | | . .. .  |||  |||    .|   |..||   |     .||||||||||||.. ..  |. . .  .| || . |..|| | |.| ||| .||
egetrlithwlwkewpdwqvpessevmlkilrkirarstp....pvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqy

TFCHDAVLE
 .    .|.
mliwkvlld
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 5-112 5.5e-16 53.1 In-house 174-277 (312) alignment 
Range on Protein: 5-112
Range on HMM: 174-277/312.0
EEREVKQFHFTVWPDHGVPEYPTAILafrRRVRAYNpPDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYTFCH
.|  .... .. |||||.|.   . |   | . | .  |  ||| ||||||||.||...|..|.  .      .. .    ||  |.  |..  || .. 
qesklnhyqwaswpdhgmpdscdtal...rllsavk.kdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyal

DAVLEAIQ
 .||| . 
rcvlefly
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 135-411 5.5e-16 52.8 In-house 21-284 (302) alignment 
Range on Protein: 135-411
Range on HMM: 21-284/302.0
KELKMTRFDSEFKTLNKVSPILPKaCyivASYPENKDKNRYSDILASDFSRVVLTAIDDNeittYINAVHISGYKQQHAFIVTQYPLTATV---SDFWRM
|.|. ..  .|||.....   | | |    .. .| .||.  |. . |  .| |.|  |.    |.|| ...  . ..  |..| | . ..    .||||
ksldtaevkkefkkidtmkvdlek.C...kafkknlkknqsedvpildsnlvkleaepds....yvnaskvevPeltrsiilaQlpkvdsedsveeFWrm

LSEQDSACVVLFQPTEEG--DFPQFWPEVgKETYDMIsvecsdeRSSSVDNLRASYDQSEIAQLRFNVKDLRTPENLhKIKMFVVSGWTSEDETPPTSSI
  ..  . ||.   .||    . ...|.   ..|           .  | | . .. . |  ..   |      . .  ... |.. | ..      ...
vfqekivsvvilvgeeelkktlselfpkk.sgdykey.......gkmfvNnrkVekaeeektryviEvlPegcsnsv.lanvyvltnWkqkkvpvkyael

ITLIAKVeRWQQQSGNGPITVVCSDGIGRSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEY
|. .|||   ...... .. .|   |.|| |.| .|  ..|... ..   . . .|..|  ||  | .   | ... |.  |
iktaakv.fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiallly
subfamily_egg_pd Subfamily egg 165-409 6.6e-16 52.8 In-house 36-267 (307) alignment 
Range on Protein: 165-409
Range on HMM: 36-267/307.0
SYPENKDKNRYSDILASDFSRVVLTAIDDNEITTYINAVHISGYKQQHAFIVTQYPLTATVSDFWRMLSEQDSACVVLFQPTEEG-DFPQFWPEVGKETY
   .|..| |   .   |.||| |       .  .| | ...|      ||..| ||  || |||||. ...   .|... . |    . .||   ... 
asdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeserceyywpkaesdsl

DMISVECsdeRSSSVDNLRASYDQSEIAQLRFNVKDlrtpenlhKIKMFvVSGWTSEDETpptSSIITLIAKVERWQQQSGnGPITVVCSDGIGRSGTFS
 ..       |  ...  ...     ...|.    |        . ..| .  |  . .    || .    .| |  ..    |. | . .|. ...|. 
vtvpGsl...rienlkvdskadplfrvtklklvGgd........deerf.lehwqgdvnn...ssdvysplrvlrklrnls.kpvvvqdilGvskaatlv

ALYSVLE---RVKIEQvIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQ
|.   |    |  | .   ||.|.. .|  |.  |...  | |..  | 
aieiallsllrGpitk.slvlravvflrlrrrlsvesvllylfvyrlvl
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 4-103 9.2e-16 52.1 In-house 185-280 (302) alignment 
Range on Protein: 4-103
Range on HMM: 185-280/302.0
KEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNppdaGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYTFC
| .. |. ..|. ||||| |. . . |   .   .|       |..||||||||.||.. |   ..    .   |. . |  .|. |   ||.|.| .. 
kvkktvdilafsawpdhGapkeaytaldilkfcesyk....knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 150-405 1.1e-15 52.0 In-house 29-272 (303) alignment 
Range on Protein: 150-405
Range on HMM: 29-272/303.0
NKVSPILPKACyIVASYPENKDKNRYSDILASDFSRVVLTaidDneiTTYINAVHISGYKQQHAfIVTQYPLTATVSDFWRMLSEQDSACVVLFQptEEG
.||.  ||        . .| ||||. |..  | |.| |.   |   ..|| | ..    ...| |.|| ||. | .|||.|. ||   ||.|.    ..
ekvvsylppsv.sknqfvknmdknrfvdvicldhskvkls...d...ssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvllll..tds

DFPQFWPE-VGKETYDMISVEcsdERSSSVDNlrasYDQSEIAQlRFNVKDLRTPENLHK--IKMFVVSGWTSEDeTPPT--SSIITLIAKVERWQQQSG
.. ..  . |  .  |..  |   |||  | .    . . |...  ...| |   .  .|  ...     |  ..  |    . ..  | ...   ..  
eydklggdsvfprnqdflkfe...ersirvge....fkrvelgd.gwvlkvlsvsngdyksflhvhhykawphns.ipsdgspkfvkqiwqlqsvlrkys

NG-PITVVCSDGIGRSGTFSALYSVLERVKIEQV-IDVLQAIKAMRIPRPGLVKTTAEYKFIH
.. |   .   | ||.|||. . .    .. ||  .|... .. .|  |   |.  ... ...
dstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvy
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 163-314 1.2e-15 51.9 In-house 31-183 (347) alignment 
Range on Protein: 163-314
Range on HMM: 31-183/347.0
VASYPENKDKNRYSDILASDFSRVVLTAID-----DNEITTYINAVHISGYKQQHAFIVTQYPLTATVSDFWRMLSEQDSA-CVVLFQPTEEGDFPQFWP
.. .  . .|||  |    | .||||.  .      ... ||||| ||   . .. .|.|||||  || |||.|.|    .  | .|.| ..    .|  
svewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikdeaieefan

evgkETYDMISVeCSDERSSSVDNLRASYDQSEIAQLRFNVKDLRTPENLHKIKMFVV
     |  ...       | .. .   . ||    . . ..| .|  .|||.  .| .
....atlslvap.aptasskdigsspvpidqiarereqieiksircesnlhrssffpl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 8-109 2.5e-15 50.9 In-house 189-287 (305) alignment 
Range on Protein: 8-109
Range on HMM: 189-287/305.0
EVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNppdaGPVIIHCSAGVGRSGTFIVIDAMLDRVNAES-SLDIFNYVAYLRTRRTAMVQTEEQYTFCHDA
 |.....| ||| |||    . | .   .|  .     |...|||||.||.|| . |. .|...  .     . . |  || .|.  .|.. || | |  
svrhlqwtewpdrgvppckltslellsairgsk....vpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrv

VLE
.|.
mln
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 42-111 2.5e-15 51.1 In-house 226-295 (297) alignment 
Range on Protein: 42-111
Range on HMM: 226-295/297.0
PDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYTFCHDAVLEAI
|   ....||||||||||  .  |..|...  .   |.   . .|| .|. .||| ||.....||||. .
prnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 164-326 3.6e-15 50.3 In-house 91-239 (244) alignment 
Range on Protein: 164-326
Range on HMM: 91-239/244.0
ASYPENKDKNRYSDILASDFSRVVLTAidDNEITTYINAVHISGYKQQHAFIVTQYPLTATVSDFWRMLSEQDSACVVLFQPTEEGDfpQFWPEVG-KET
|  |.|  ||| .  |  ||.|| |.    .   |||||  .    .   .|.||.||. |  |||.|. |.    .|..   || |  ..||.    | 
afnpnnswknregaglpfdfnrvplsk..gsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed..eywpdseplew

YD-MISVECSDErsSSVDNLRASYdqSEIAqlrfnvKDLRtpENLHKIKMFVVSGWTSEDETPPT
|.  |.|  .|       |..||    ||        |.   |    . || .| | |.  ||  
yeeditvtltdr..defknikasn..leie......sdmn..eshqaltmfqisnwpsdgttpnd
0048076 (Phosphotyrosine protein) phosphatases II 311-411 3.6e-15 51.4 In-house 49-142 (145) alignment 
Range on Protein: 311-411
Range on HMM: 49-142/145.0
MFVVSGWTSEDETPPTSSIITLIAKVERWQQQsgNGPITVVCSDGIGRSGTFSALYSVLErvkiEQvIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQE
 ..  .|   .. . .. ...... .|.....  .||. | || |.||.||. |.| .|.    .. ... .|.. .|  ||| | .   ..|......|
qylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqrpgavpnpgqlrflyefele

Y
.
l
subfamily_CG42327_pd Subfamily CG42327 167-257 5.3e-15 49.9 In-house 26-120 (319) alignment 
Range on Protein: 167-257
Range on HMM: 26-120/319.0
PENKDKNRYSDILASDFSRVVLTAIDDNEITTYINAVHISGYKQQHA-FIVTQYPLTATVSDFWRMLSEQDSACVV-LFQPTEEG--DFPQFWPE
.  |||.|. ...    .||||  | |.. . |..| .. ||.. .. .| .| .|  . |||||.. || |  .| | .. | |    ....| 
vtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPt
0048179 (Phosphotyrosine protein) phosphatases II 310-406 8.1e-15 50.3 In-house 50-139 (144) alignment 
Range on Protein: 310-406
Range on HMM: 50-139/144.0
KMFVVSGWTSEDETPPTSSIITLIAKVERWQQqsGNGPITVVCSDGIGRSGTFSALYSVLervkIEQvIDVLQAIKAMRIPRPGLVKTTAEYKFIHY
  ..  .|   .  . .. ...... .|....   .||. | || |.||.||. |.| ..     .. ... .|.. .|  ||| | .   ..|...
iqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrfLle
subfamily_CG42327_pd Subfamily CG42327 43-105 1.6e-14 48.3 In-house 246-309 (319) alignment 
Range on Protein: 43-105
Range on HMM: 246-309/319.0
DAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAE-SSLDIFNYVAYLRTRRTAMVQTEEQYTFCHD
. ||...||| ||||.|. |  |  . ...    |.|| . | ..|  |.  |.| ||| | . 
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiyk
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 349-412 5.1e-14 46.4 In-house 2-65 (69) alignment 
Range on Protein: 349-412
Range on HMM: 2-65/69.0
TVVCSDGIGRSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYL
 | || | ||.||| |.   . |.| |...|..  .. ||  || .|    || ||| |. | |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 350-412 6.4e-14 46.1 In-house 2-64 (69) alignment 
Range on Protein: 350-412
Range on HMM: 2-64/69.0
VVCSDGIGRSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYL
| || | ||.||| |.   . |.| |...|..  .. ||  || .|    || ||| |. | |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 8-108 1.1e-13 45.6 In-house 216-341 (350) alignment 
Range on Protein: 8-108
Range on HMM: 216-341/350.0
EVKQFHFTVWPDHGVPEYPTAILAFRR---------RVRAYN-PPDAGPVIIHCSAGVGRSGTFIVIDAMLD------R---------VNAESSLDIFNY
.| |...  |.| ..   |  ||               . .     . |...|||||||| ||.. .| .|                 | |.    |.  
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

VAYLRTRRTAMVQTEEQYTFCHDAVL
|  || .|  |||. .|. |...|.|
vnelrkqrismvqnldqfifiYeall
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 5-109 1.6e-13 45.3 In-house 165-268 (285) alignment 
Range on Protein: 5-109
Range on HMM: 165-268/285.0
EEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNPPDaGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYTFCH
|   ... .   |||.  ||    .. . . |.  || .  |. .||||||||. ||. ||    |.  .  ..... |  .|. |   ||.  |. | .
eplymnhvqvpwwpdqlapedarpmielykwvkkvnpke.kpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflfly

DAVLE
  ..|
vvlme
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 5-101 4e-12 40.5 In-house 179-271 (301) alignment 
Range on Protein: 5-101
Range on HMM: 179-271/301.0
EEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNppdaGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYT
. | |  . .. |.|.|||.  . .  .   |.  .     |...|||||.||| .||  . .  .|.|.  ... . .. || .|   |||..|  
atrtvthyqysewtdrgvPkshaelfdlmelvkkse....kPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqly
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 3-111 1.8e-11 38.6 In-house 112-221 (255) alignment 
Range on Protein: 3-111
Range on HMM: 112-221/255.0
EKEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRaynppDAGPVIIHCSAGVGRSGTFIVIDAMLD----RVNAE--SSLDIFNYVAYLRTRRTAMVQT
 |. ..|| .... |...  || .  ||   . ||     |. .|..|||.|.||| .|.... .       ..      ||  . .  || .|.. ..|
kkkthtvkhysykGWieknaPelareilnilkvvr.....dsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraiht

EEQYTFCHDAVLEAI
  | .|.   ||. .
Plqlafsilmvldlv
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 159-278 1.9e-11 38.3 In-house 37-170 (350) alignment 
Range on Protein: 159-278
Range on HMM: 37-170/350.0
ACYIVASYPENKDKNRYSDILASDFSRVVLT-------AIDDN-EITTYINAVHISG----YKQQHAF--IVTQYPLTATVSDFWRMLSEQDSACVVLFQ
  .|...  |   ||||..||  . ||| |        |..   .   |||| ...      ...  |  | || ||  || ||.... . .   ..  .
nDvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilslt

PTEEGDF---PQFWPEVGketYDMISVECSDERSSSV
.  | .     ..|.| .   || | |  .. . . .
sdvelnlekcyrYWqegs...ydditvklaskwenim
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 184-412 4.8e-11 37.3 In-house 33-257 (290) alignment 
Range on Protein: 184-412
Range on HMM: 33-257/290.0
SRVVLTAIDDNEITTYINAVHISgYKQQHAFIVTQYPLTAT-------VSDFWRMLSEQDSACVVLFQPTEEGDFP-------QFWPE-VGK-ETYDMIS
.||||          || | ... . .  ..|.|| |....       . .|| |  .  .  ||     || .         .. || ||.  ... ..
trvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkglt

VECsdersssvdNLRASYDQSEIAQLRFNVKDlrtpENLHKIKMFVVSGWTSEDETPPTSSIITLIAKVErwqqqSGNGPITVVCSDGIGRSGTFSALYS
|.|           .   |. |. .|  .  |    |. ....   ..||..    . | ....|| ||.       . |. | | ||| || ...|.  
vkC.........kskekeddvetRelvvkfdd....eeeftvtHsllkgWnklnvqedtktllsliqkvk.....asktpvivHcvdGiSrsAalaaiil

VLERVK-IEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQeyL
    .   .. . . ...||.|  |  .. .. |. |. ...   |
gyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv..l
subfamily_CG42327_pd Subfamily CG42327 325-413 9.6e-11 35.9 In-house 227-316 (319) alignment 
Range on Protein: 325-413
Range on HMM: 227-316/319.0
PTSSIITLIAKVERWQQQSGNGPITVVCSDGIGRSGTFSALYSVLERVKIE-QVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYLA
 |||         |  ... .||..| ||||.||.|.  |    .....   . .|. | .  .|  |   |.|   |.||.  ..|| .
stssheingnissrsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 4-108 1e-10 35.7 In-house 187-287 (310) alignment 
Range on Protein: 4-108
Range on HMM: 187-287/310.0
KEEREVKQFHFTVWPDHGVPEYPTAILAfrRRVRAYNppDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYTFC
 .|  |.  ..  ||| |||.     .   .|. |      ||...|||||..| .. . ..  .|...    .|. . .. |. .|.  .||| ||.. 
lkelrvslikwpnwpdrgvpdekchtvp..qrllaqv..rhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqylii

HDAVL
.   .
drvri
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 141-218 2.2e-10 34.6 In-house 24-94 (95) alignment 
Range on Protein: 141-218
Range on HMM: 24-94/95.0
RFDSEFKTLNKVSpilpKACYIVASYPENKDKNRYSDILASDFSRVVLTAIDDNEittYINAVHISGYKQQHAFIVTQ
 || |||...  |     | | | |   |  |||. .|.  | .|||||.  | .   ||||. . || .. ..| .|
efdnefksismts....gapytvgsseanipknrflnifpydatrvvlttkrdsd...yinacfvdgyarkncyiaaq
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 13-108 2.8e-10 34.1 In-house 187-282 (302) alignment 
Range on Protein: 13-108
Range on HMM: 187-282/302.0
HFTVWPDHGVPEYPTAILAFRRRVRAYNPPDAGPVIIHCSAGVGRSGTFIVIDAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYTFCHDAVL
..| |... ||.  ... .    | | . .   ...|    |.|| |.|..  . ........   | . |. .|. |...|.. .||.. . |.|
vltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiall
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 182-324 2.8e-10 34.6 In-house 6-128 (130) alignment 
Range on Protein: 182-324
Range on HMM: 6-128/130.0
DFSRVVltaiddneITTYINAVHISGYKQQHAFIVTQYPLTATVSDFWRMLSEQDSACVVLFQPTEEGDfpQFWPEVGKET-YD-MISVECSDerSSSVD
..||.           |||||  .    .   .. || ||..|  |||.|. |.    .|..   || |  ..||.      |.  | |  .|     ..
evsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed..eywpdsePlewyeediivtltd..rdefk

NLRASYDQSEiaqlrfnvKDLRtpENLHKIKMFVVSGWTSEDETP
|..||. . |        .||   |  . . || .| | |.  ||
nikasnleie........sdln..eshqaltmfqisnwpsdgttp
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 165-414 7.5e-10 33.0 In-house 39-278 (312) alignment 
Range on Protein: 165-414
Range on HMM: 39-278/312.0
SYPENKDKNRYSDILASDFSRVVLTAidDNEITTYINAVHISgyKQQHAFIVTQYPLTATVSDFWRMLSEQDSACVVLFQPTEEGDFPqfwpEVGKETYD
..   || ||| .|   |  |  |.   |...  . | |.|    .   |..|| ||  |.. ||..     |....|.    |        .. |   |
aflkfkdlnrypniqcwdrgrftlag..denfyihanfvkic..tkperfvctqgplentcthfwqlalslgstsiillcgfvedgse....kcakyisd

MIS-VECSD-----ERSSSVDNLRASYDQSEIAQLRFNVKDlrtPENLHKIKMFVVSGWTSEDETPPTSSIITLIAKVERWQQqsgngPITVVCSDGIGR
... |.  |     |  . ..    | |.     |.  ||      .  |.. .  . |          .   |.. | . ..     |.   || |.||
ivgfvdledhrvyteycteieiggkskdkithrvlkvvvka...tgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk.....pviahcsagvgr

SGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYLAA
.||.  . |..  ..  .  .| ..   .|  |   |.. ..| .   .| |.| .
tgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflys
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 5-104 1.3e-09 32.5 In-house 93-197 (199) alignment 
Range on Protein: 5-104
Range on HMM: 93-197/199.0
EEREVKQFHFTVWPDHGVPEY---PTAILAFRRRVRAYNPPDAGPVIIHCSAGVGRSGTFIVIDAMLDRV--NAESSLDIFNYVAYLRTRRTAMVQTEEQ
  ||. .. || | ..  |.       ..| |   . |.     |||.||| | | .| |. .|  .        | .|.|.    ||  |  .. . ..
streishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqh

YTFCH
| | .
ynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 5-104 1.3e-09 32.5 In-house 92-196 (198) alignment 
Range on Protein: 5-104
Range on HMM: 92-196/198.0
EEREVKQFHFTVWPDHGVPEY---PTAILAFRRRVRAYNPPDAGPVIIHCSAGVGRSGTFIVIDAMLDRV--NAESSLDIFNYVAYLRTRRTAMVQTEEQ
  ||. .. || | ..  |.       ..| |   . |.     |||.||| | | .| |. .|  .        | .|.|.    ||  |  .. . ..
streishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqh

YTFCH
| | .
ynfiy
subfamily_eak_pd Subfamily eak 38-118 1.7e-09 31.5 In-house 231-312 (332) alignment 
Range on Protein: 38-118
Range on HMM: 231-312/332.0
AYNPPDAGPvIIHCSAGVGRSGTFIVIDAMLDRVNA--ESSLDIFNYVAYLRTRRTAMVQTEEQYTFCHDAVLEAIQCGNTQI
 . ||   | || .. |  |.|.|.||| ..  ...  . .  . ...   ...|   | .. |..| ...||. ..  | ..
ihtppsfap.iiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnrl
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 5-118 3.8e-09 31.1 In-house 156-257 (290) alignment 
Range on Protein: 5-118
Range on HMM: 156-257/290.0
EEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNppdaGPVIIHCSAGVGRSGTFIVIDAMLDRVN-AESSLDIFNYVAYLRTRRTAMVQTEEQYTFC
||  |.   .  | .  |.| .  .|.  . |.|..     |||.||  |. || ..  |.     .   ..|. . . . .|| .|  .........| 
eeftvtHsllkgWnklnvqedtktllsliqkvkask....tpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafv

HDAVLeaiqcgntqI
  ...         .
dagiv.........l
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 166-247 4.4e-09 30.2 In-house 31-111 (332) alignment 
Range on Protein: 166-247
Range on HMM: 31-111/332.0
YPENKDKNRYSDILASDFSRVVLTAIDDNEitTYINAVHISGYKQQHAFIVTQYPLTA-TVSDFWRMLSEQDSACVVLFQPTE
. .| | ||   . . |.||| |.  | ..   . ||  . || .. |.|..| |.   |   ||||.||.  . ...|   .
flnnmdmnriphlycfdhsrvelapqdgkd..dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdid
0038934 (Phosphotyrosine protein) phosphatases II 293-405 4.4e-09 31.8 In-house 39-170 (194) alignment 
Range on Protein: 293-405
Range on HMM: 39-170/194.0
LRFNVKDLRTPENLHKIKMFVVSGWTS-----------------------ED-ETPPTSSIITLIAKVERWQQQSGNGPITVVCSDGIGRSGTFSALYSV
.||...||    .|.. |.. |  .|                        .| ..|... . . .  |... ... .| . | |  |.||.||. | | .
yrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLi

LErvkieQVIDVLQAIKAMRIPRPGLVKTTAEYKFIH
       . ... .||. .|. ||| . .   .. ..
yr.....lgmsaeeAialfrekRpgaipnqdyleall
subfamily_ptpA1_pd Subfamily ptpA1 3-70 5.4e-09 30.3 In-house 182-255 (418) alignment 
Range on Protein: 3-70
Range on HMM: 182-255/418.0
EKEEREVKQFHFTVWPDHGVPEYPTAILA----FRRRVRAYNPP--DAGPVIIHCSAGVGRSGTFIVIDAMLDR
| | |.. |...  |||| .|..   .         |     |      |.|.||||||||.|||     |. .
egetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkk
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 39-109 5.7e-09 29.8 In-house 260-342 (349) alignment 
Range on Protein: 39-109
Range on HMM: 260-342/349.0
YNPPDAGPVIIHCSAGVGRSGTFIVIDAMLD------------RVNAESSLDIFNYVAYLRTRRTAMVQTEEQYTFCHDAVLE
..  .  ....||||| ||.|... .| .|.             ..|     |.  |  ||  | .|||   |. ....|.|.
ldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLk
subfamily_hpo-7_pd Subfamily hpo-7 4-110 1.2e-08 29.2 In-house 119-226 (263) alignment 
Range on Protein: 4-110
Range on HMM: 119-226/263.0
KEEREVKQFHFTVWPDHGVPEYPTAILAFRRRVRaynppDAGPVIIHCSAGVGRSGTFIVIDAMLD----RVNAE--SSLDIFNYVAYLRTRRTAMVQTE
|. ..||.. .. |...  || .  ||   . .|     .  ....|||.|.|||  | |.. .       ..      ||  . .  || .|.. ..| 
kkthtvkhysykgWiekndpelareilnilkvar.....nskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtP

EQYTFCHDAVLEA
 |  |    ||. 
mqLafsilmvLdf
0038934 (Phosphotyrosine protein) phosphatases II 7-87 1.2e-08 30.3 In-house 77-156 (194) alignment 
Range on Protein: 7-87
Range on HMM: 77-156/194.0
REVKQFHFTVWPDHGVPEYPTAILAFRRRVRAYNPPD-AGPVIIHCSAGVGRSGTFIVIDAMLdRVNAeSSLDIFNYVAYLR
.   ...   .||.|..     .| | . |  ..  |  | | .|| ||.||.||...   .  | .  |  .  ....  |
kagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiy.rlgm.saeeAialfrekR
subfamily_eak_pd Subfamily eak 162-327 3e-08 27.4 In-house 45-198 (332) alignment 
Range on Protein: 162-327
Range on HMM: 45-198/332.0
IVASYPENKDKNrYSDILASDFSRVVLTAIDDNEiTTYINAVHISGYKQQHAFIVTQYPLTATVSDFWRMLSEQDSACVVLFQPTEEG---DFPQFWPEV
 ...  |. ..|   .|.  |.  | ||.   |.   ||||  .   .  . .|.|  .    |  ||.|. || | ..| .    |     . ...|. 
setarleavnrn.vvkivpydrylvrltssqlnr.lGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdk

GKETYDMisvecsdersSSVDNLRASYDQSEIAQLRfnVKDLRTPENLHKIKMFVVSGWTsEDETPPTS
..| ..             .|  | .. . .| . |     |.  .. |... . | ||| | ..|   
treelkf..........Gildverkefvkrniletr..llelskGnethrvlhykvfGwt.ettlpkye
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 163-208 9.3e-08 25.8 In-house 41-86 (440) alignment 
Range on Protein: 163-208
Range on HMM: 41-86/440.0
VASYPENKDKNRYSDILASDFSRVVLTAIDDNEITTYINAVHISGY
.|| |.|| |||| .||| |.|||.|  .     . |||| .|.| 
iaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 205-257 1.4e-07 25.2 In-house 229-281 (440) alignment 
Range on Protein: 205-257
Range on HMM: 229-281/440.0
ISGYKQQHAFIVTQYPLTATVSDFWRMLSEQDSACVVLFQPTEEGDFPQFWPE
. || .. ||| || || .|| ||||.. .   . .....  ..     .|| 
fegyskknafiatqmpldstvldfwrlvhdyristiimlnqlndktcsiywpv
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 218-404 1.6e-07 25.1 In-house 97-280 (302) alignment 
Range on Protein: 218-404
Range on HMM: 97-280/302.0
QYPLTATVSDFWRMLSEQDSACVVLFQPTEEGDFPQFWPEVGKETYDMISVECSDERSSSV-DNLRASYDQSEIAQLRFNVKDLRTPENL-HKIKMFVVS
  |   |.  .| .. . . | || .    |..  .. .   ..  . .       .. || ..|    |. ..     ..|. .. ... . ..... |
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

GWTSEDETPPTSSIITLIAKVERWQQQsgngpITVVCSDGIGRSGTFSALYSVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFI
.|        . . . ..   | ....     . | || |.||.||. |.   ..  . ..| |.|. .. .|  | | |..     ..
awpdhGapkeaytaldilkfcesykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 161-257 4.1e-07 23.6 In-house 40-155 (349) alignment 
Range on Protein: 161-257
Range on HMM: 40-155/349.0
YIVASYPENKDKNRYSDILASDFSRVVLTA--------------IDDNEITTYINAVHIS--GYKQQHAFIVTQYPLTATVSDFWRMLSEQDSACVVLFQ
.|...  |   ||||.|||  . |||.|                 |   .  |||| ...   .. .. .| || || .|| ||....  .    |.  .
vilseGvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLn

PTEEGDFPQ---FWPE
  .| .. .   .| |
ddkelslekcdiywqe
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 216-407 4.4e-07 24.2 In-house 39-216 (255) alignment 
Range on Protein: 216-407
Range on HMM: 39-216/255.0
VtqypltaTVSDFWRMLSEQDSACVVLFQPTEE---GDFPQFWPEV--GKETYDMISVECSDerSSSVDNLRASydqsEIaqlrfnVKDLRTPENLHKIK
.       ||  |....  ...  ||..   .|    .  ...|    .|  .  ..| ...  ||.   ||.     ||      .  |    . |..|
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtl....ei......tstlgekkkthtvk

MFVVSGWTsEDETPPTSSIITLIAKVERwqqQSgnGPITVVCSDGIGRSGTFSALYSVLER----VKIE--QVIDVLQAIKAMRIPRPGLVKTTAEYKFI
 .   ||  |  .|  .  |  | || |   .|   .. |.|| ||||| .|    .|  .    ..      .| |. .. .|  |.. ..|  .  | 
hysykGWi.eknaPelareilnilkvvr...ds..ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafs

HYA
 . 
ilm
subfamily_PTPDC1_pd Subfamily PTPDC1 12-105 5.5e-07 24.2 In-house 85-170 (182) alignment 
Range on Protein: 12-105
Range on HMM: 85-170/182.0
FHFTVWPDHGVPEYpTAILAFRRrVRAYNpPDAGPVIIHCSAGVGRSGTFIVIDAMLDrvnaeSSLDIFNYVAYLRTRRTAMVQTEEQYTFCHD
..   |.|.||.   . ||   . | |.   . | | .|| || || |  |    .       ..|.  . .  .| .|.  .|| ||  ....
vynfgwkDygvasl.eriLdivk.vvafa.lqegkvavhChaGlGrtGvliacylvya.....krltaekaiklvrskrpksiqtreqvelvke
subfamily_PTEN_pd Subfamily PTEN 313-407 9e-07 24.0 In-house 81-175 (184) alignment 
Range on Protein: 313-407
Range on HMM: 81-175/184.0
VVSGWTSEDETPPTSSII-TLIAKVERWQQQSGNGPITVVCSDGIGRSGTFSALYsVLERVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYA
 |. .  .|..||. ... ... ..|.| ... .  . | |  | ||.|.  . | .|.. ..|.  ..|.  ...|      |.  .  ....| 
rvavypfdDhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivay.llkslllekaeealelfaeaRtknkkgvtiPsqrRYveYy
PTEN_1 8-62 1.4e-06 23.2 In-house 94-148 (196) alignment 
Range on Protein: 8-62
Range on HMM: 94-148/196.0
EVKQFHFtVWPDHGVPEYPTaILAFRRRVRAYNP--PDAGPVIIHCSAGVGRSGTFI
 |.. ||  ..|||.|     .... ...  .    |. . |..|| ||.||||| .
gveylhf.pieDhgapslse.lfdicksfiewllsdpngnvVlVHCkaGlgRsGtvv
subfamily_ptpA1_pd Subfamily ptpA1 66-112 1.5e-06 22.2 In-house 353-399 (418) alignment 
Range on Protein: 66-112
Range on HMM: 353-399/418.0
AMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYTFCHDAVLEAIQ
|..|. |.   ...|. |  || .|  |||  ||| ||. ..|. | 
aimdkynsridfnlfsivlklreqrpgmvqqleqylfcyktildeiy
PTPc_motif_SM00404 43-93 1.7e-06 23.0 In-house 79-123 (140) alignment 
Range on Protein: 43-93
Range on HMM: 79-123/140.0
DAGPVIIHCSAGVGRSGTFIVIDAMLDR-VNAESSLDIFnyvaylRTRRtAM
. | |..|| ||| ||.|.|.   |  | ..........      . ||  .
kggkvlVHCqaGvSRSatliiaYlmryrqlslaeayefv......kerR.pi
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 12-112 3.3e-06 20.9 In-house 176-280 (303) alignment 
Range on Protein: 12-112
Range on HMM: 176-280/303.0
FHFTVWPD-----HGVPEYPTAILAFRRRVRAYNPpdAGPVIIHCSAGVGRSGTFIVID-AMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQYTFCHD
 |.  ||      .| |..   |   .  .| | .  . | .    .|.||.||| ... | |   . ..|||. . .  .|  |   ||   |... . 
hhykawphnsipsdgspkfvkqiwqlqsvlrkysd..stptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvyt

AVLEAIQ
 . | . 
llaehvl
subfamily_egg_pd Subfamily egg 44-108 3.6e-06 20.9 In-house 201-267 (307) alignment 
Range on Protein: 44-108
Range on HMM: 201-267/307.0
AGPVIIHCSAGVGRSGTFIVIDAMLDR-VN-AESSLDIFNYVAYLRTRRTAMVQTEEQYTFCHDAVL
. ||....  || ...|.. |.  |   .        . . | .|| ||   |..  .| | .  ||
skpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
subfamily_hpo-7_pd Subfamily hpo-7 221-403 4.6e-06 20.7 In-house 43-218 (263) alignment 
Range on Protein: 221-403
Range on HMM: 43-218/263.0
LTATVSDFWRMLSEQDSACVVLFQP-TEE--GDFPQFWPE--VGKETYDMISVECSDERSssvDNLRASYDqseIaqlrfnVKDLRTPENLHKIKMFVVS
|  |.  |....  . .  ||..   .||   .  ...|    .|  .  ..| ...  |   | |  . .   .      .. |    ..|..| .   
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs...dvllktle...l......lstlgeKkkthtvkhysyk

GWTSEDETPPTSSiITLIAKVERwqqQSgnGPITVVCSDGIGRSGTFSALYSVLERV--KIE----QVIDVLQAIKAMRIPRPGLVKTTAEYKF
||  . .   . . |  | || |   .|   .. |.|| |||||  ||   .|  ..   ..      .| |. .. .|  |.. ..|     |
gWiekndpelare.ilnilkvar...ns..kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLaf
subfamily_PTEN_pd Subfamily PTEN 9-99 5e-06 21.6 In-house 82-168 (184) alignment 
Range on Protein: 9-99
Range on HMM: 82-168/184.0
VKQFHFTvwpDHGVPEYpTAILAFRRRVRAYNPPDAGPV-IIHCSAGVGRSGTFIVIdAMLDRVNAESSLDIFNYVAYLRTRRTAMVQTEEQ
|... |.   ||  |.    . .. . ....   |   | ..|| || ||.|. ||   .| .   |.. .. .. |  ||. .  |.   |
vavypfd...Dhnpppl.elleeivediekwleedkknvvvvHCkaGkGRtGvliva.yllkslllekaeealelfaeaRtknkkgvtiPsq
DSPc Dual specificity phosphatase, catalytic domain 44-96 6.5e-06 21.0 Pfam-A 73-120 (133) alignment 
Range on Protein: 44-96
Range on HMM: 73-120/133.0
AGPVIIHCSAGVGRSGTFIVIDAMldRVNAESSLDIFNYVaylRTRRTAMVQT
 . |..|| ||. ||.|.|.   |  . .  |. . ...|   . || .....
gkkvlVHCqaGisRSatliiaYlm..ktknlslneAyefv...kerrskispn
DSPc Dual specificity phosphatase, catalytic domain 44-96 6.5e-06 21.0 In-house 73-120 (133) alignment 
Range on Protein: 44-96
Range on HMM: 73-120/133.0
AGPVIIHCSAGVGRSGTFIVIDAMldRVNAESSLDIFNYVaylRTRRTAMVQT
 . |..|| ||. ||.|.|.   |  . .  |. . ...|   . || .....
gkkvlVHCqaGisRSatliiaYlm..ktknlslneAyefv...kerrskispn
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 315-413 8.5e-06 18.6 In-house 213-310 (346) alignment 
Range on Protein: 315-413
Range on HMM: 213-310/346.0
SGWTSEDETPPTSSIITLIAKVERWQQqSGNGPITVVCSDGIGRSGTF-SALYSVLeRVKIEQVIDVLQAIKAMRIPRPGLVKTTAEYKFIHYAVQEYLA
. |   .. | |  || .| .    .|   |  . ||   | ||. .|  |||..  ..      .... .|...  ||| |.. |.|  |.  | .|.|
apwkhlqqppktlpiikmihqflsekq.vqnagvcvvslfgcgracsfigalyain.qlnngiepniceimknikqqrpggvesfaqyasiyaivfdyia