Gene NvecPTP-sf3-1 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily NvecPTP-sf3
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP056_AA protein Get Run
NvecP056_AA_0-137 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 25-137 8e-82 268.2 In-house 85-197 (198) alignment 
Range on Protein: 25-137
Range on HMM: 85-197/198.0
NKETAPPSTREISHYQFTSWKEKTTPNVALFVGFVVASREVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKTSVVDLFEVAKRLRQARCG
|. |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
nnttappstreishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcg

IISSLQHYNFIYQ
|||||||||||||
iisslqhynfiyq
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 28-137 2.7e-81 266.5 In-house 89-198 (199) alignment 
Range on Protein: 28-137
Range on HMM: 89-198/199.0
TAPPSTREISHYQFTSWKEKTTPNVALFVGFVVASREVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKTSVVDLFEVAKRLRQARCGIIS
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
tappstreishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiis

SLQHYNFIYQ
||||||||||
slqhynfiyq
0046845 (Phosphotyrosine protein) phosphatases II 2-137 1.6e-34 115.0 In-house 91-268 (284) alignment 
Range on Protein: 2-137
Range on HMM: 91-268/284.0
ADFWQMVWETGSGHIVMVNDDQKNKETA------------------------------------------PPSTREISHYQFTSWKEKTTP-NVALFVGF
.|||.|||| .. .|||...   |. .                                           .  .|.. |...||| .  .| ... .. |
edFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedllef

VVASREVSKKyeQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESK-TSVVDLFEVAKRLRQARCGIISSLQHYNFIYQ
. . ||. ..   ... |..||||.| | ||.|.|||.  .  |. . ...||..|. ||||. |.| . .|..| |.|.
lrlvrellen..lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvye
0051299 (Phosphotyrosine protein) phosphatases II 2-137 6e-34 113.2 In-house 106-280 (288) alignment 
Range on Protein: 2-137
Range on HMM: 106-280/288.0
ADFWQMVWETGSGHIVMVNDDQKNKE--------------------------------------------TAPPSTREISHYQFTSWKEKTTPN-VALFV
.|||.|||| .. .|||... . ..                                             . .  .|.. |...|.| .  .|. . |..
edFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspelll

GFVVASREVSKkyeqEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESktSVVDLFEVAKRLRQARCGIISSLQHYNFIYQ
 |. . |.. .     .. ||.||||.| | ||.|.|||. ..  |.    .||..|. ||||. |.|.. ....| |.|.
dflrlvrkala....sgggpvvVHCsaGvgRtgtfialdllleqleke..ggvdvleavkrlreqRpgmvqtpeqyrfvye
0050432 (Phosphotyrosine protein) phosphatases II 2-137 6.1e-34 113.1 In-house 122-293 (308) alignment 
Range on Protein: 2-137
Range on HMM: 122-293/308.0
ADFWQMVWETGSGHIVMVNDDQKNKE-------------------------------------------TAPPSTREISHYQFTSWKEKTTPN-VALFVG
.|||.|||| .. .|||... . |.                                            .  . .|.. |...|.|..  .|. .. .. 
edFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilld

FVVASREVSkkyeqeKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESktSVVDLFEVAKRLRQARCGIISSLQHYNFIYQ
|. . |..       .. |..||||.| | ||.|.|||. ..  |.     ||.||. |.||. |.| . ....| |.|.
flelvrksl......pggpivVHCsaGvGRtGtfialdllleqleke..ggvdvfeavkklReqRpgmvqtpeqylflyr
0036941 (Phosphotyrosine protein) phosphatases II 2-137 3.8e-33 110.5 In-house 92-271 (297) alignment 
Range on Protein: 2-137
Range on HMM: 92-271/297.0
ADFWQMVWETGSGHIVMVNDDQKNKE--------------------------------------------TAPPSTREISHYQFTSWKEKTTPN-VALFV
.|||.|||| .. .|||....  .                                              |  . .|.. |...|.| .  .|. .| ..
edFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespasll

GFVVASREVSKKYeqEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEES-KTSVVDLFEVAKRLRQARCGIISSLQHYNFIYQ
 |. . |.| |..   .. ||.||||.| | .|.|.|.|. ..  |.. |.  ||..|. | ||. |.|.. .|..| |.|.
dfielvrkvlkll..psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflye
0047943 (Phosphotyrosine protein) phosphatases II 2-137 4.4e-33 110.3 In-house 91-266 (273) alignment 
Range on Protein: 2-137
Range on HMM: 91-266/273.0
ADFWQMVWETGSGHIVMVNDDQKNKET-------------------------------------------APPSTREISHYQFTSWKEKTTP-NVALFVG
.|||.|||| .. .|||..... ..                                               . .|.. |...|.| .  .| ... .. 
edfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppsleslle

FVVASREVSKKYEQEkdAPVIVHCSDGQGFTGVFVALDIGVRSHEESktSVVDLFEVAKRLRQARCGIISSLQHYNFIYQ
|. . |.. ... ..   ||.||||.| | ||.|.|||. ..  |.     ||..|. |.||. |.|.. ....| |.|.
fielvrkalealpsn..gpvvVHCsaGvgRtgtfialdllldqleke..ggvdvleavkllrsqRpgmvqtpeqyrflye
0040438 (Phosphotyrosine protein) phosphatases II 2-137 2.4e-32 107.9 In-house 100-270 (317) alignment 
Range on Protein: 2-137
Range on HMM: 100-270/317.0
ADFWQMVWETGSGHIVMVNDDQKNK----------------------------------------ETAPPSTREISHYQFTSWKEKTTP-NVALFVGFVV
.|||.|||| |...|||...   ..                                         .  . .|.. |...|.| . ..| .  |.. |. 
edFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfle

ASREVSKkyeqEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKtsVVDLFEVAKRLRQARCGIISSLQHYNFIYQ
| ||. .    ... ||.||||.| | ||.|.|... ..  |. .   ||..|. |.||..|.|.. ....| |.|.
avreale....dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg..gvdveeavkelreqRpgavqtpeqyrflyd
0045450 (Phosphotyrosine protein) phosphatases II 2-137 2.7e-32 108.2 In-house 121-298 (307) alignment 
Range on Protein: 2-137
Range on HMM: 121-298/307.0
ADFWQMVWETGSGHIVMVNDDQKNKET------------------------------------------APPSTREISHYQFTSWKEKTTP-NVALFVGF
.|||.|.|| |...|||....  ..                                                .|.. |...|.| . ..| ... .. |
edFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldf

VVASREVSKKYeqEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKTSV-VDLFEVAKRLRQARCGIISSLQHYNFIYQ
. . |.. ...   |. ||.||||.| | ||.|.|...  | .|. .|   |||.|. |.||. |.|.. ....| |.|.
ieevrkaleel..pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflye
0043336 (Phosphotyrosine protein) phosphatases II 2-137 1.8e-31 105.0 In-house 102-271 (278) alignment 
Range on Protein: 2-137
Range on HMM: 102-271/278.0
ADFWQMVWETGSGHIVMVNDDQKNKE---------------------------------------TAPPSTREISHYQFTSWKEKTTP-NVALFVGFVVA
.|||.|||| |. .|||....  ..                                        .  . .|.. ||....| . ..| ...|.. |. |
edFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflka

SREVSKkyeqEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKtsVVDLFEVAKRLRQARCGIISSLQHYNFIYQ
 ||. .     .. ||.||||.| | ||.|.||.. ..  |  .   |||.|. |.||. |.|.. ....| |.|.
vreale....dsngpvlVHCsaGvgRTGtfialyllleqlekeg..gvdleeavkelreqRpgavqtpsqyrflye
0039614 (Phosphotyrosine protein) phosphatases II 2-137 4.3e-31 103.9 In-house 115-283 (297) alignment 
Range on Protein: 2-137
Range on HMM: 115-283/297.0
ADFWQMVWETGSGHIVMVNDDQKNKE------------------------------------TAPPSTREISHYQFTSWKEKTTP-NVALFVGFVVASRE
.|||.|||| |. .|||...   ..                                     |    .|.. |.|.|.| . ..| ...|.  |. . ||
edFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvre

VSKKYeqEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESktSVVDLFEVAKRLRQARCGIISSLQHYNFIYQ
. ...  .|. ||.||||.| | ||.|.|... ..  |.     ||..|. |.||..|.|.. ....| |.|.
alael..pkggpvlVHCsaGvgRtGtfiaaylmleqleke..ggvdvleavkelreqRpgavqtpsqyrflyd
0045098 (Phosphotyrosine protein) phosphatases II 2-137 7.5e-30 99.7 In-house 78-266 (278) alignment 
Range on Protein: 2-137
Range on HMM: 78-266/278.0
ADFWQMVWETGSGHIVMVNDDQKNK--------------------------------------------ETAPPSTREISHYQFTSWKEKTTPNVALFVG
||||.|.|| |. .|||... . ..                                            | .   .|.. |.....| . ..|.  .   
adfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilks

FVVASREVSKKYE------------QEKDAPVIVHCSDGQGFTGVFVALDIGVRSHeeskTSVVDLFEVAKRLRQARCG-IISSLQHYNFIYQ
|  . ... . ..            .... ||.|||| | | ||..||...  .       ..|||.|. | ||. |.| .. .|..|.|.|.
flellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell....eggvdlleavkelrsqRpglavqnleqyrflye
0042113 (Phosphotyrosine protein) phosphatases II 2-137 1.6e-29 98.5 In-house 66-237 (245) alignment 
Range on Protein: 2-137
Range on HMM: 66-237/245.0
ADFWQMVWETGSGHIVMVNDDQKNKET----------------------------------------APPSTREISHYQFTSWKEKTTPN-VALFVGFVV
.|||.|.|| |. .|||....  ..                                            . .||. ||....| . ..|. ..|.. |. 
edfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldfle

ASREVSKKyeqEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEesKTSVVDLFEVAKRLRQARCGIISSLQHYNFIYQ
. |.. ..    .. ||.||||.| | ||.|.|... ..  |  |.  |.|.|. |.||. |.|.. ....| |.|.
fvrkalae...dsngpvlVHCsaGvgRtGtfiaaylmleqle..kelgvsleeavkelrsqRpgavqtpsqyrflye
0040439 (Phosphotyrosine protein) phosphatases II 2-137 1.9e-29 98.5 In-house 68-240 (249) alignment 
Range on Protein: 2-137
Range on HMM: 68-240/249.0
ADFWQMVWETGSGHIVMVNDDQKNK----------------------------------------ETAPPSTREISHYQFTSWKEKTTP-NVALFVGFVV
.|||.|.|| |...|||..... ..                                         .  ...|.. |.|.|.| .  .| ... .. |. 
edfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfie

ASREVSKKYeqEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEesKTSVVDLFEVAKRLRQARCGIISSLQHYNFIYQ
| |.. ...  .|. ||.||||.| | ||.|.|... ..  |  |.  |||.|. | ||..|.|.. ....| |.|.
avrkaleel..pkggpvlVHCsaGvgRtGtfiaaylmleqle..kelgvdleeavkllrsqRpgavqnpeqyrflye
0037934 (Phosphotyrosine protein) phosphatases II 2-137 1.1e-26 89.4 In-house 58-236 (243) alignment 
Range on Protein: 2-137
Range on HMM: 58-236/243.0
AD----FWQMVWETGSGHIVMVNDDQKNKET---------------------------------------APPSTREISHYQFTSWKEKTTPN-VALFVG
.|    ||.|.|| |...|||..... ..                                         ... ||.. ||....| . ..|. .. .. 
eddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlld

FVVASREVSKKY----EQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHeesktSvVDLFEVAKRLRQARCG-IISSLQHYNFIYQ
|. . ||. ...       .. ||.|||| | | ||...|...  .       . |||.|. |.||. |.| .. ....| |.|.
fldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll.....g.vdleeavkllreqRpgkavqtpsqyrflye
Y_phosphatase Protein-tyrosine phosphatase 28-137 5.1e-25 83.6 Pfam-A 126-231 (235) alignment 
Range on Protein: 28-137
Range on HMM: 126-231/235.0
TAPP-STREISHYQFTSWKEKTTP-NVALFVGFVVASREVSkkyeQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKTsvVDLFEVAKRLRQARCGI
.. .  .||......|.|.....| ..  .. .. . .. .    ..|..||.||||.| | ||.|||||| ... |. ..  ||.... |.||. |.|.
kkeesekrevkqlhytnWpdhgvpespkslldlirkveksk....eaksgpvvVhCsaGvgRtgtfvaldilleqleaeee..vdvlqivkelRkqRpgm

ISSLQHYNFIYQ
..||. | |.|.
vqsleqYiflyk
Y_phosphatase Protein-tyrosine phosphatase 28-137 5.1e-25 83.6 In-house 126-231 (235) alignment 
Range on Protein: 28-137
Range on HMM: 126-231/235.0
TAPP-STREISHYQFTSWKEKTTP-NVALFVGFVVASREVSkkyeQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKTsvVDLFEVAKRLRQARCGI
.. .  .||......|.|.....| ..  .. .. . .. .    ..|..||.||||.| | ||.|||||| ... |. ..  ||.... |.||. |.|.
kkeesekrevkqlhytnWpdhgvpespkslldlirkveksk....eaksgpvvVhCsaGvgRtgtfvaldilleqleaeee..vdvlqivkelRkqRpgm

ISSLQHYNFIYQ
..||. | |.|.
vqsleqYiflyk
0036282 (Phosphotyrosine protein) phosphatases II 4-137 1.4e-24 82.2 In-house 28-164 (174) alignment 
Range on Protein: 4-137
Range on HMM: 28-164/174.0
FWQMVWETGSGHIVMVNDDQKNK---------ETAPPSTREISHYQFTSWKEKTTPNVALFVGFVVASREVSKKyeqEKDAPVIVHCSDGQGFTGVFVAL
||.|..| |. ..||... . ..         |.    .|.. .|... |   ..|... .  || . .|. ..    .. ||.|||| | | ||..||.
fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealse...dpggpvlVHCsaGvgRtGtlvaa

DIGVRSHEeskTSVVDLFEVAKRLRQARCGIISSLQHYNFIYQ
..  | ..   .|.|| ... ..||. |.|.. . ..| |.|.
ylmlrgll...eslvdaldlvrelRlqrpgmvqtpsQyrflyy
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 32-136 1.6e-24 81.6 In-house 176-276 (305) alignment 
Range on Protein: 32-136
Range on HMM: 176-276/305.0
STREISHYQFTSWKEKTTPNVAlfVGFVVASREVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHeeSKTSVVDLFEVAKRLRQARCGIISSLQH
 .| ...||.|.| ..  |. |    ..   ..| |.....|. |..||||.| | ||||.|.|| .      |  |||.||| |.||. | .....|..
esrtvlqyqltdWPdhGvpqfa..tsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerl..kkEevvdvfevlkqlRskrmkmvqtldq

YNFIY
|.|..
Yvflh
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 32-137 2.6e-24 80.9 In-house 176-277 (319) alignment 
Range on Protein: 32-137
Range on HMM: 176-277/319.0
STREISHYQFTSWKEKTTPNVALFVgfVVASREVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHeeSKTSVVDLFEVAKRLRQARCGIISSLQH
 |||..|.|.|.| ..  |. |. .  .   ... |  |.... |..||||.| | || |..||. .     .. .|.|.|....|||  |  ...  . 
etRevkhfqyteWpdhdvPekatsl..ldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlerv..keegvlDvfstvsrlRtqRnimvqrpeq

YNFIYQ
|.|||.
Ykfiye
0043147 (Phosphotyrosine protein) phosphatases II 1-137 3.6e-24 80.8 In-house 33-155 (172) alignment 
Range on Protein: 1-137
Range on HMM: 33-155/172.0
MADFWQMVWETGSGHIVMVNDDqknKETAPPSTREISHYQFTSWKEKTTPNVALFVGFVvasREVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVrs
.||||.|..| | .|||....      .... .|.. .|....|   ..|. .|.  |.   . . ... .... ||.|||| | | ||..||...    
ladfwrmlkelgithivnltel...lydpellerlgiqylylpwpDhgvpllelllefl...efidellalspggpvlVHCsaGvgRtgtlvaaylml..

heesktS-VvDLFEVAKRLRQARCGIISSLQHYNFIYQ
        . .|.|. . .|..|.|.. . ..|.|.|.
......lgl.sleeavalvrekRpgavqnpsqyrflyy
subfamily_PTPRD_pd Subfamily PTPRD 30-137 1.3e-23 78.5 In-house 173-275 (564) alignment 
Range on Protein: 30-137
Range on HMM: 173-275/564.0
PPSTREISHYQFTSWKEKTTPNVAlfVGFVVASREVSKKYeQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEEskTSVVDLFEVAKRLRQARCGIISSL
  ..||. ...|||| ..  |. |   ...   |.|..   ...  |..|||| | | ||.|...|. ..  .|    .||.... |.||. |  .. . 
ssesreVrqFhFtsWPdhgvpesa..tslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerike..ektvDiyqyvkalrkqRnamVqte

QHYNFIYQ
. | ||..
eQYiFihe
DSPc_SM00195 31-137 2.1e-23 78.4 In-house 155-256 (263) alignment 
Range on Protein: 31-137
Range on HMM: 155-256/263.0
PSTREISHYQFTSWKEKTTP-NVALFVGFVVASREVSKKYeqekDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKTsvVDLFEVAKRLRQARCGIISSL
  ||.. .||...|... .| .   .. .. | .. ...     ..|..||||.| | ||.||..|| ... || |.  ||.||. |.||. |.|....|
eetrkvtqyqyknWpdhgvpdstksvlellravkksksts....sgpivVhCsaGvgRtgtfvtidiilskleeekk..vdifeivkelRkqRpgmvqtl

QHYNFIYQ
..| |||.
eqYlfiye
PTPc_SM00194 31-137 2.1e-23 78.4 In-house 155-256 (263) alignment 
Range on Protein: 31-137
Range on HMM: 155-256/263.0
PSTREISHYQFTSWKEKTTP-NVALFVGFVVASREVSKKYeqekDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKTsvVDLFEVAKRLRQARCGIISSL
  ||.. .||...|... .| .   .. .. | .. ...     ..|..||||.| | ||.||..|| ... || |.  ||.||. |.||. |.|....|
eetrkvtqyqyknWpdhgvpdstksvlellravkksksts....sgpivVhCsaGvgRtgtfvtidiilskleeekk..vdifeivkelRkqRpgmvqtl

QHYNFIYQ
..| |||.
eqYlfiye
PTPc_DSPc_SM00012 36-137 3.7e-23 77.1 In-house 2-101 (105) alignment 
Range on Protein: 36-137
Range on HMM: 2-101/105.0
ISHYQFTSWKEKTTPNVAlfVGFVVASREVSKKYEQEK-DAPVIVHCSDGQGFTGVFVALDIGVRSHEESKtSVVDLFEVAKRLRQARCGIISSLQHYNF
..||..|.|... .|. .    .. . |.| |......  .||.||||.| | ||.|||||| ....|... . ||.|.. |.||. | | ..... | |
vkhyhytgwpdhgvPees..dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket.kevdifqivkelrkqRpgmvqteeqylf

IYQ
.|.
lyr
0041856 (Phosphotyrosine protein) phosphatases II 2-137 9e-23 76.2 In-house 48-165 (182) alignment 
Range on Protein: 2-137
Range on HMM: 48-165/182.0
ADFWQMVWETGSGHIVMVNddqKNKETAPPSTREISHYQFTSWKEKTTPNVALFVGFVVASREvskkyeqeKDAPVIVHCSDGQGFTGVFVALDIGVRSh
|||..|..| | ..||...        .   .|.. .|....|   ..|..  .. |. . .|        .. ||.|||| | | ||..||...  .  
adflrmlkelgittivnlt...eelywpellerlgiqylylpwpDhgvpdldelldfieevle........eggpvlVHCsaGvgRtgtlvaaylmkkl.

eesktSvVDLFEVAKRLRQARCGIISSLQHYNFIYQ
     . |.|.|. | .|..|.|.. ....| |...
.....g.vsleeavklvrsrRpgmvitpnqyfflql
subfamily_CG7180_pd Subfamily CG7180 30-137 2.1e-22 74.1 In-house 176-284 (296) alignment 
Range on Protein: 30-137
Range on HMM: 176-284/296.0
PPSTREISHYQFTSWKE-KTTPNV-ALFVGFVVASREVSKKY-EQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEesKTSVVDLFEVAKRLRQARCGII
   || . ..|.| |.  .  | . . .. ..   | . .|  |... .||.|..|||.. .||..|.|. .   |  |.  ||.|| .|.||. | ...
kaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelve..keeevdvFeavktlrrsRpqLv

SSLQHYNFIYQ
 . ..| .||.
enveeYkyiYd
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 33-137 2.5e-22 74.3 In-house 160-262 (274) alignment 
Range on Protein: 33-137
Range on HMM: 160-262/274.0
TREISHYQFTSWKEKTTPNVALFVGFVVASREVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEEskTSVVDLFEVAKRLRQARCGIISSLQHY
.|.. || .|.| .. .|. |  .  .|.  | |.. |..| |||.|||| | | ||.|.| .|.||  .|  ..|||....   ||. | |.. . . |
ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlre..eivvdvlkivcnlrldrGGmvqtseqy

NFIYQ
..|..
elihr
0049260 (Phosphotyrosine protein) phosphatases II 1-137 4e-22 74.0 In-house 22-144 (152) alignment 
Range on Protein: 1-137
Range on HMM: 22-144/152.0
MADFWQMVWETGSGHIVMVNDDQKNKETAPPSTReisHYQFTSWKEKTTPNVALFVGFVVASREVSkkyEQEKDAPVIVHCSDGQGFTGVFVALDIGVrs
.||||.|..| | ..|||..... ...   .      .|... |   ..|. . .. |..   |      ..|. ||.|||| | | ||..||...    
ladfwrmlkelgittivmltellelgklkceqyi...qylhlpwpDhgvpdlsqlllflllfiekl...aldkggpvlVHCsaGvgRtgtlvaaylml..

heesktSVVDLFEVAKRLRQARCGIISSLQHYNFIYQ
        |.|.|. ...|..| |.. . ... |.|.
......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Ptp69D_pd Subfamily Ptp69D 26-137 1.2e-21 72.2 In-house 174-280 (307) alignment 
Range on Protein: 26-137
Range on HMM: 174-280/307.0
KETAPPSTREISHYQFTSWKEKTTPNVALfvGFVVASREVSKKYEQEkDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKtsVVDLFEVAKRLRQARCGI
. .  . .|..  |..|.||. . |.||   | .   ..| . |...  .|..|||| | | .|.|||||. .   .. .   ||.||. | ||. |  .
esgevedsrkvvqyhytgWkDskvPevar..gllklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaed..kvdifetvkdLrsqRnll

ISSLQHYNFIYQ
. ||. | |.|.
vqsleqYvflyr
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 31-137 1.8e-21 71.7 In-house 182-284 (298) alignment 
Range on Protein: 31-137
Range on HMM: 182-284/298.0
PSTREISHYQFTSWKEKTTPNVALFVgfVVASREVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEesKTSVVDLFEVAKRLRQARCGIISSLQ
 ..||. . .|||| .|..|..|  |  .   |.| .. .| ...||||.||.| | .| |.|.|  .   .  | .|||.|.| |.||. |.|.. . .
ekerevrqlhftsWpdkgvpenatsv..ldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervk..keqvvDvfqvvkvlRkkrpgavqtee

HYNFIYQ
.| |||.
qYvfiye
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1-136 2.2e-21 70.7 In-house 101-229 (392) alignment 
Range on Protein: 1-136
Range on HMM: 101-229/392.0
MADFWQMVWETGSGHIVMVNDDQKNKETapPSTREISHYQFTSWKEKTTPNVALfvGFVVASREVSKKYEQEKdAPVIVHCSDGQGFTGVFVALDIGVrS
. |||.||..     |.||.. ..       ..| .. ..|| | .|  |. .    ..   .||. .. |    |.|.||| | | ||| ...|  | .
lddfwrmvfqenvttiamvtklkegdkg..ddartvaqfhftewPdkdvpkhts..sllkfikevkadfGqyt.hpliihcsagvgrtgvvisidsvv.a

HEeSKTSVVDLFEVAKRLRQARCGIISSLQHYNFIY
|   || .||.|..   .|. |  .. . ..| |||
ha.kktrmvdvfnfvtnirrkrpymvqtkeqyafiy
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 32-137 3.3e-21 70.5 In-house 150-258 (270) alignment 
Range on Protein: 32-137
Range on HMM: 150-258/270.0
STREISHYQFTSWKEKTTPNVAL----FVGFVVASREVSKKYEQEKD-APVIVHCSDGQGFTGVFVALDIGVRSHEESKtsVVDLFEVAKRLRQARCGII
..|.. |.....| ... |. .         .   |.| .  .. ..  |..||||.| | ||...||||.||  ||.|   ||. .. ..||. |. ..
eerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetk..kvdvlaiieelRkdRmalv

SSLQHYNFIYQ
.  ..|.|.|.
qhpeqyeflyk
subfamily_PTPRK_pd Subfamily PTPRK 32-137 4.1e-21 70.1 In-house 171-271 (314) alignment 
Range on Protein: 32-137
Range on HMM: 171-271/314.0
STREISHYQFTSWKEKTTPNVAlfVGFVVASREVSKKYEQeKDAPVIVHCSDGQGFTGVFVALDIGVRSHEesKTSVVDLFEVAKRLRQARCGIISSLQH
 .||. ..||..| .  .|. |   |..   |.| |. |. .. ...|||| | | ||.|.|.|| .   |  . .|||.|...| ||. .  ..   . 
eirevrqfqflgWpdhdvPvsa..tgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmie..regvvdvfnavktlrsrkvnmveteeq

YNFIYQ
|.|||.
ykfiyd
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 28-137 4.7e-21 70.2 In-house 169-274 (318) alignment 
Range on Protein: 28-137
Range on HMM: 169-274/318.0
TAPPSTREISHYQFTSWKEKTTPNVAlfVGFVVASREVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKtsVVDLFEVAKRLRQARCGIIS
|   ..|..  |..||| .. .|. .  ....   |.|||  ....  |..|||| | | ||||.|.|| ..  .. .  .||.|.. |.||. |  .. 
teeeesrqvrqyhytsWpdegvpesg..aslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaea..lvDvfqtvkqlreqrnlmvq

SLQHYNFIYQ
  . |.|||.
tedqyefiyd
0051082 (Phosphotyrosine protein) phosphatases II 1-137 7.5e-21 69.7 In-house 22-147 (151) alignment 
Range on Protein: 1-137
Range on HMM: 22-147/151.0
MADFWQMVWETGSGHIVMVNDDQ---KNKETAPPSTREISHYQFTSWKEKTTPNV----ALFVGFVVAsrevskkyeqEKDAPVIVHCSDGQGFTGVFVA
.|||.....| |  .||......   ...|  |   .|. |.....|.. ..|      . |. .. .           |. ||.|||| | | ||..||
ladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellld..........kkngpvlvHCsaGkgRTGtlva

LDIGVRSheesktsvVDLFEVAKRLRQARCGIISSLQHYNFIYQ
|..  .         |.|.|. . .|. |.|.. . |.. |...
lylmllg........vsleealeeyrlkrpgvvqpnqqflfqlf
0046846 (Phosphotyrosine protein) phosphatases II 1-137 7.9e-21 70.0 In-house 36-167 (176) alignment 
Range on Protein: 1-137
Range on HMM: 36-167/176.0
MADFWQMVWETGSGHIVMVNDDQKNKET-----APPSTREISHYQFTSWKEKTTPNVALFVGFVVASREVSKKYeqekdAPVIVHCSDGQGFTGVFVALD
.|||..|..| | ...|......  .        |  ...  .|... | . ..|. .|.  .. . ||. |.       ||.|||| | | ||..||..
ladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefirealkeg.....gpvlVHCsaGigRtgtlvaay

IGVRsheeskTSVVDLFEVAKRLRQARC-GIISSLQHYNFIYQ
.  .         ....|. ...|. |. |.. . ..| |.|.
llel......ekglsveealalvreqRplgavqtpeQyrflye
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 33-137 1.4e-20 68.6 In-house 174-273 (288) alignment 
Range on Protein: 33-137
Range on HMM: 174-273/288.0
TREISHYQFTSWKEKTTPNVAL-FVGFVvasREVsKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEEskTSVVDLFEVAKRLRQARCGIISSLQH
 .|| .||...| ..  |. .  .....   | | |  .|..  |.|||||.| | ||.|.|||  .   ||  . ..|.... ..||. |  ..  |..
eleitqyqylaWpdhgvPeskapllell...rqv.kvanqadtgpiivhCsaGvGrtgtFialdalidavee..edyiDvagtvaklRkqRallvqtlkq

YNFIYQ
| |||.
Yefiye
subfamily_PTPRB_pd Subfamily PTPRB 32-137 1.7e-20 68.3 In-house 177-279 (293) alignment 
Range on Protein: 32-137
Range on HMM: 177-279/293.0
STREISHYQFTSWKEKTTPNVA-LFVGFVVASREVSKKyeQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEEskTSVVDLFEVAKRLRQARCGIISSLQ
..|.. .|.|||| .   |. .  .. || . ||. .|  .....|..|||| | | ||.|.|||  ... ||  . .||.| .  .||. |. .. . .
eerkvrqyhftsWpdhgvPektktlldfvrtvreaiek..taskrPivvhCsaGvGRtGtfialdrllqaiee..edyvdifgivaelReeRnllvqtek

HYNFIYQ
.| ||.|
qYifihq
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 32-137 3.9e-20 67.1 In-house 135-236 (250) alignment 
Range on Protein: 32-137
Range on HMM: 135-236/250.0
STREISHYQFTSWKEKTTPNVALFVgfVVASREVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKtsVVDLFEVAKRLRQARCGIISSLQH
. | . ...|..| .|. |.||  |  .   ..| .. .| ..|||||.|| | | .| |.|.|  .   ...|  |||.|.| |.||. | . . ||. 
derivrqlhfvvWPdkgvPevatav..LellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkek..vvdvfkvikvlrkdrphavesleq

YNFIYQ
| |.|.
yvfvye
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 25-137 4.2e-20 66.8 In-house 170-277 (290) alignment 
Range on Protein: 25-137
Range on HMM: 170-277/290.0
NKETApPSTREISHYQFTSWKEKTtpNVALFVGFVVASREVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEesKTSVVDLFEVAKRLRQARCG
||..|  ..... .||.|.|...   .|.   . ... .|. |.  .. . ...|||||. | ..||.|.....   .  .. |.|.|.| |..|. . |
nknsa.gakqsvtqyqitnwdstg..kvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkck..tegvidvfqvlksqRiqkpg

IISSLQHYNFIYQ
 . . |.|..|.|
svqtvqqyqgifq
subfamily_PTPN6_pd Subfamily PTPN6 30-137 5e-20 66.7 In-house 182-291 (306) alignment 
Range on Protein: 30-137
Range on HMM: 182-291/306.0
PPSTREISHYQFTSWKEKTTPNVAL-FVGFVVASREVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKTSV-VDLFEVAKRLRQARCGIIS
  ..||. .|.|.|| .. .|.    .. |.   .. ... |...  |..||||.| | || |. .|| ..  |.... . .|. .. | .|. | |.. 
kkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvq

SLQHYNFIYQ
  | |.|.|.
teqqykfvyk
subfamily_PTPRG_pd Subfamily PTPRG 26-137 7.9e-20 65.6 In-house 174-281 (563) alignment 
Range on Protein: 26-137
Range on HMM: 174-281/563.0
KETAP-PSTREISHYQFTSWKEKTTPNVALFVGFVVASREVSKKyeqEKDAPVIVHCSDGQGFTGVFVALDIGVRshEESKTSVVDLFEVAKRLRQARCG
|..    . ... .|..|.| ....|. .|.|   |  .. ..|   ..  |..|||| | | ||....||  ..  .  . ..|..|...|..|  |  
kkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaank...aeaGPivvHcsaGvgrtGtyivldtllk..qiqqenavnvfgflkhiraqRnf

IISSLQHYNFIYQ
.. .   | |...
lvqteEqYiflhd
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 32-137 9.7e-20 65.8 In-house 168-270 (281) alignment 
Range on Protein: 32-137
Range on HMM: 168-270/281.0
STREISHYQFTSWKEKTTPNVAlfVGFVVASREVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEeSKTSVVDLFEVAKRLRQARCGIISSLQH
 |||... ..|.| ..  |. .    ..   .|| |  |....||...||| | | ||...|||  |.. | .... .|. .| . ||..|  .. ..  
etreveqlaytaWPdhGvPatt..kellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkave.aeleeldvkavvaelrkernlmvqtvvq

YNFIYQ
|.|.|.
yefvyk
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 31-137 1.7e-19 65.1 In-house 174-278 (297) alignment 
Range on Protein: 31-137
Range on HMM: 174-278/297.0
PSTREISHYQFTSWKEKTTPNVALFVGFVVASREVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEesKTSVVDLFEVAKRLRQARCGIISSLQ
 ..| .  |||..| .|. ..      ..    || |...|....|..|||. | | |||....|  |   .  ..  ||.|.. |.||| |  ..   .
karrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeak..rekevdifglvkklrqerpylvqtke

HYNFIYQ
.|.|.|.
qykfvyv
0051429 (Phosphotyrosine protein) phosphatases II 2-137 2.3e-19 65.6 In-house 36-219 (272) alignment 
Range on Protein: 2-137
Range on HMM: 36-219/272.0
ADFWQMvWETGSGHIVMVNDDQ---KNK----------------------ET----------------------------APPSTREISHYQFTSWKEKT
||||.. .| |  .||.. ..    ..|                       .                             .  .||. |...|.|    
adfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhg

TPN--VALFVGFVVAsrevskkyeqekDAPVIVHCSDGQGFTGVFVALDIGVrsHEESKTSVVD--------LFEVAKRLRQARCGIISSLQHYNFIYQ
.|   .  .. .. .            . ||.|||| | . ||..|||.. .  .  |.. .||        |.|. ..||..| |.. . ..| |.|.
vpqeallellellld............ggpvlvHCsaGkdRTGtvvalllll..lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflye
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 33-137 4.6e-19 63.5 In-house 174-273 (315) alignment 
Range on Protein: 33-137
Range on HMM: 174-273/315.0
TREISHYQFTSWKEKTTPNVAlfVGFVVASREVsKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKtsVVDLFEVAKRLRQARCGIISSLQHY
 ||.  ...||| .   |. .  . ..   | | |...... ....||||.|.| || |..||  .   |  .  ..|.... ...|| | ....... |
irevvqlhytswpdmgvpkyt..iplmnlirtv.kqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaen..aidvynfitgvrqnrikmvqvaeqy

NFIYQ
.|||.
qfiyd
subfamily_PTPN14_pd Subfamily PTPN14 33-137 5.2e-19 63.4 In-house 182-290 (300) alignment 
Range on Protein: 33-137
Range on HMM: 182-290/300.0
TREISHYQFTSWKEKTTPN-VALFVGFVVASREVSKKYEQEK-----DAPVIVHCSDGQGFTGVFVALDIGVRSHEESKtsVVDLFEVAKRLRQARCGII
 |.. | |.| | ..  |. |  |. ..   . | .| ..|.     . ||.||||.| | ||| .  |. . . |  .  ..|. .| .|||. |  ..
ertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehne..eidikkvlarLreqrmllv

SSLQHYNFIYQ
..|  |.|.|.
qtlaqYkfvYk
subfamily_PTPRA_pd Subfamily PTPRA 27-137 8e-19 62.7 In-house 184-289 (330) alignment 
Range on Protein: 27-137
Range on HMM: 184-289/330.0
ETAPPSTREISHYQFTSWKEKTTPNVAlfVGFVVASREVSKKYEQEKDaPVIVHCSDGQGFTGVFVALDIGVRS-HEEsktSVVDLFEVAKRLRQARCGI
.|   ..| .. . |||| .   |  .  .| .   ..| |. .|. . |..|||| | | || |..||  .   . |    .||.||. ||||. |. .
atrekksrlvrqfhftswPdvGvPfep..iGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkae...rkvdvfefvkrlrlqrpqm

ISSLQHYNFIYQ
. ... |.|||.
vqtdeqyefiyk
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 32-136 4.1e-18 60.7 In-house 183-284 (319) alignment 
Range on Protein: 32-136
Range on HMM: 183-284/319.0
STREISHYQFTSWKEKTTPNVALFVGFVVAS-REVSKKYEqeKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKtsVVDLFEVAKRLRQARCGIISSLQ
  |.|  . |  | ..  |. .  .  .|   | . .| .  . |...|||| | | |||...||. .   .| |   ||.... . ||| |  .. .| 
dirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltsken..hranivvhcsaGvGrtGvyivldvlldrmkeek..qvdvynfvrdlrqqrntlvqdlv

HYNFIY
 | |||
qykfiy
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 32-137 4.6e-18 60.2 In-house 171-272 (287) alignment 
Range on Protein: 32-137
Range on HMM: 171-272/287.0
STREISHYQFTSWKEKTtpNVALFVGFVVASREVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEesKTSVVDLFEVAKRLRQARCGIISSLQH
.....  ||.|.|...   .|. .   ..   |  |.  .. .....|||||. | ...|.| .....  .  .  |.|.|.| |. |. . | .   ..
dkqqvkqyqitnWdstg..kvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkck..teGviDvfqvlksqriqkpgsvqtveq

YNFIYQ
|.||..
ykfind
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 32-136 5.3e-18 60.5 In-house 147-248 (284) alignment 
Range on Protein: 32-136
Range on HMM: 147-248/284.0
STREISHYQFTSWKEKTTPNVALFVGFVVAS-REVSKKYEqeKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESktSVVDLFEVAKRLRQARCGIISSLQ
  |.|  . |  | ..  |. .  .  .|   | ...| .  . |...|||| | | |||...||. .   .|   . ||.... . ||| |  .. .| 
dirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltsken..hranivvhcsagvgrtgvyivldvlldrmkee..kqvdvynfvrdlrqqrntlvqdlv

HYNFIY
 | |||
qykfiy
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 33-136 2.3e-17 57.8 In-house 161-259 (283) alignment 
Range on Protein: 33-136
Range on HMM: 161-259/283.0
TREISHYQFTSWkekTTPNVALFVGFVVASREVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHeeSKTSVVDLFEVAKRLRQARCGIISSLQHY
|  ..|||.  |   .  .    .  .|    |  .  ..|..|..|||| | | |.||.|.   |        ||||.|.| | .|. | ... .|. |
tlllahyqvidW...leygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkda..ltesvvdvfavvkimreqrmmavqtldqy

NFIY
 ...
klvh
0044763 (Phosphotyrosine protein) phosphatases II 2-137 3.1e-17 58.2 In-house 38-165 (178) alignment 
Range on Protein: 2-137
Range on HMM: 38-165/178.0
ADFWQMVWETGSGHIVMVNDDQKN---KETAPPSTREISHYQFTSWKEKTTPN-VALFVGFVVASREVSkkyeQEKDAPVIVHCSDGQGFTGVFVALDIG
||......| | .|||...... .   |. .   ...  .|... .   ..|.  . |  || . .|.     .||. ||.|||| | | .|..||... 
addlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeal....dekggpvlVHCsaGvgRsgtlvaaylm

VRSheesktSVvDLFEVAKRLRQARCgIISSLQHYNFIYQ
 .       .. .|.|. ...|..|. |. .  .....|.
kkl......gl.sleeaielvrerRp.ivpnpgqlrqLye
subfamily_PTPN12_pd Subfamily PTPN12 32-137 3.8e-17 57.1 In-house 168-271 (290) alignment 
Range on Protein: 32-137
Range on HMM: 168-271/290.0
STREISHYQFTSWKEKTTPNVALFvgfVVASREVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKT-SVVDLFEVAKRLRQARCGIISSLQ
 .|..  ...|.| .. .|. |     ...  |  .......|||..|||| | | ||. .|.|.  .  .. |. . .|.|..  .||. |  .. . .
esrkvyqfhYtaWPDhgvPssaks...llelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtke

HYNFIYQ
 |...|.
qyelvyk
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 33-137 4.1e-17 57.0 In-house 172-271 (315) alignment 
Range on Protein: 33-137
Range on HMM: 172-271/315.0
TREISHYQFTSWKEKTTPNVALfvGFVVASREVSKKyEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHeeSKTSVVDLFEVAKRLRQARCGIISSLQHY
.| .. .||| | .| ... .    ..   .||  . ...|. ...|||| | | |||....|  |      .|..||.|.. | ||. |  .. . ..|
srtvtqfqftewPdkGvdkqts..sllklikevkad.ngkkefsllvhcsaGvGrtGvvisidevvaqi..krtrsvdvfnfvknlrakrpylvqteeey

NFIYQ
 |||.
afiyd
subfamily_PTPN3_pd Subfamily PTPN3 31-135 5.2e-17 56.7 In-house 168-267 (280) alignment 
Range on Protein: 31-135
Range on HMM: 168-267/280.0
PSTREISHYQFTSWKEKTTPNV-ALFVGFVVASREVSkkyeQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKTsvVDLFEVAKRLRQARCGIISSL
   |.| . |...| ... |.  | |. ||   |..     . |. ||.|||| | | |||...|.. .   |...   |   .. ...|. |  .. . 
keerkilqlqylaWpdhgvPddsadflefvervrklr....sgkeePvvvhCsaGigrtGvlilletalalieaaep..vypldivrtmrdqramlvqta

QHYNFI
. |.|.
sqykfv
subfamily_PTPN9_pd Subfamily PTPN9 31-136 5.2e-17 56.8 In-house 170-283 (297) alignment 
Range on Protein: 31-136
Range on HMM: 170-283/297.0
PSTREISHYQFTSWKEKTTPNVAL-FVGFVVASRE--------VSKK-YEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEEskTSVVDLFEVAKRLRQ
  .|...|.||.|| .  .|. |  .. .. . ||        ....   . .. |..|||| | | || |..||| .   ||  ...||..|. |.||.
eesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrlee..vgtvdvvetvkllrt

ARCGIISSLQHYNFIY
 |   |   . |.| |
qrafsiqtpeqyefcy
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 32-137 6.7e-17 56.1 In-house 186-287 (301) alignment 
Range on Protein: 32-137
Range on HMM: 186-287/301.0
STREISHYQFTSWKEKTT---PNVALFVgfvVasREVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVrshEESK-TSVVDLFEVAKRLRQARCGIIS
|....  .| |.| .      |.  | |   .   .| ..  .   .||.|||||. . .||.....||.   |  |   |||.|.| |..|. . | . 
sswdvlqlqvtdWpqdGvvreprtvLqv...i..ddvihrqqkigggpvvVHCSdtVsrsGvYcsvsigl...EQckaegVVdvfqvtkavrrskpgaVt

SLQHYNFIYQ
 |. | .||.
TLeqytsiyd
subfamily_CG42327_pd Subfamily CG42327 65-137 8e-17 55.9 In-house 238-309 (319) alignment 
Range on Protein: 65-137
Range on HMM: 238-309/319.0
VSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKTSvVDLFEVAKRLRQARCGIISSLQHYNFIYQ
 |.  ..|.  |..|||||| | ||. .| || .|| |||| | ||. ..   .|. |.  . . . |.|||.
ssrsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrs.vdiPqlvssvrrdrasavltkeqyefiyk
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1-28 9.2e-17 55.9 In-house 18-45 (199) alignment 
Range on Protein: 1-28
Range on HMM: 18-45/199.0
MADFWQMVWETGSGHIVMVNDDQKNKET
|||||||||||||||||||||||||||.
madfwqmvwetgsghivmvnddqknkea
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1-28 1.2e-16 55.4 In-house 17-44 (198) alignment 
Range on Protein: 1-28
Range on HMM: 17-44/198.0
MADFWQMVWETGSGHIVMVNDDQKNKET
.||||||||||||||||||||||||||.
ladfwqmvwetgsghivmvnddqknkea
subfamily_PTPN23_pd Subfamily PTPN23 31-137 1.3e-16 55.3 In-house 168-274 (288) alignment 
Range on Protein: 31-137
Range on HMM: 168-274/288.0
PSTREISHYQFTSWKEKTTPN-VALFVGFVVASREVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHeESKTSVVDLFEVAKRLRQARCGIISSL
  ....|| |.||| |   |.    .. |. . ..  .. ... ..|..|||| | | ||||  .   ||   | .  ..|. .| .|||. |   ..  
davksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrel.ekgnglldiiqvvsrlreqRrfmvqek

QHYNFIYQ
....| |.
eqlkfsye
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 33-137 2.7e-16 53.8 In-house 171-270 (515) alignment 
Range on Protein: 33-137
Range on HMM: 171-270/515.0
TREISHYQFTSWKEKTTPNVAlfVGFVVASREVSKKYEQEKdAPVIVHCSDGQGFTGVFVALDIGVRSHeeSKTSVVDLFEVAKRLRQARCGIISSLQHY
.| .  ..|| | .| .|. .    ..   .||  . .| .  |.|.||| | | |||....|  |      .| .||.|.. . .|| |  ..   ..|
srtvtqfhfteWPdkGvpkht..ssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvvaha..kttrmvdvfnfvtnirqkrpylvqtqeqy

NFIYQ
 |||.
afiyg
subfamily_PTPN13_pd Subfamily PTPN13 31-137 4e-16 54.1 In-house 163-263 (273) alignment 
Range on Protein: 31-137
Range on HMM: 163-263/273.0
PSTREISHYQFTSWKEKTTPNVAL-FVGFVVASREVSKkyeqeKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKtsVVDLFEVAKRLRQARCGIISSL
  .||..| .|..| .  .|. |. .. ||   |.. .     . .|..|||| | | .|.....|. .   |  |   .|. |. ..||. | |.. . 
gesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.....dagPivvhcsaGiGrsGtlitidvvlglierdk..efdvkeivrklreqrqgvvqtk

QHYNFIYQ
. | |.|.
dqyifvyk
0049772 (Phosphotyrosine protein) phosphatases II 3-136 4.4e-16 55.0 In-house 99-273 (314) alignment 
Range on Protein: 3-136
Range on HMM: 99-273/314.0
DF----------WQMV--WETGSGHIVM---------------------VND----------------DqknKET--APPSTREISHYQFTSWKEKTTPN
||          |.||  ..  .  |||                      ..                    .|.  ..  .|.. .|  . .   ..| 
dfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgngneptaadlellk...eelydpelferlgikylripvpDgsapl

VALFVGFVVASREVskkyeqEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEesktsvVDLFEVAKRLRQARC-----GIISSLQHYNFIY
 . |  |. . .|.      .|. ||.|||..| | ||.||.... .. .       |.| |. ...|..|      | | .|..| ||.
ledfdeflefieea......dkggpvlvHCkaGkgRtgtfvvaaylmkllg......vsleealedvrlkRpinpnpgfieqleqyefil
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 32-137 2.4e-15 51.4 In-house 131-233 (237) alignment 
Range on Protein: 32-137
Range on HMM: 131-233/237.0
STREISHYQFTSWKEKTTPNVALFVgFVVASREVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKtsVVDLFEVAKRLRQARCGIISSLQH
  | |  |||||| ..  |. .  . .    . . .     . .| |.||| | | ||.|. .|  .|  .| |  |||...  . . . |  || . ..
evrlihqyqftswpdrgvpqqtaal.lrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekk..vvdiynyvysieedrpyiiqtkdq

YNFIYQ
| ||.|
yvfihq
subfamily_PTPRN_pd Subfamily PTPRN 31-136 4e-15 50.3 In-house 184-285 (297) alignment 
Range on Protein: 31-136
Range on HMM: 184-285/297.0
PSTREISHYQFTSWKEKTTPNVALfvGFVVASREVSKKYEQeKDAPVIVHCSDGQGFTGVFVALDIGVRSHEEsKTSVVDLFEVAKRLRQARCGIISSLQ
  || .. . | ||.|...|  |    ..   | | | |   . .|..|||||| | |||....|. .          .|.    . ||. | |.. . .
setrtvtqfhflswpeegvPasak..sllefrrkvnksyrG.rscpivvhcsdGaGrtGvyilidlvlnrllk.Gvkeidiaatlehlrdqrpglvktkd

HYNFIY
 ..|..
qfefal
subfamily_PTPN1_pd Subfamily PTPN1 31-136 7.6e-15 49.4 In-house 159-264 (290) alignment 
Range on Protein: 31-136
Range on HMM: 159-264/290.0
PSTREISHYQFTSWKEKTTPNV-ALFVGFVVASREVSKKyeQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESK-TSVVDLFEVAKRLRQARCGIISS
  ||||.|. .|.| . . |.  | |. |.   ||      ...  |...||| | | .| |. .|  .   |... .| ||. .|   ||. | |.|  
qetreilhfhyttwpdfgvpespaaflkflfkvresGsl..ssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqt

LQHYNFIY
 .  .| |
adqlrfsy
0048076 (Phosphotyrosine protein) phosphatases II 7-137 1.1e-14 49.8 In-house 24-137 (145) alignment 
Range on Protein: 7-137
Range on HMM: 24-137/145.0
MVWETGSGHIVMVnddqknKETAPPSTREISHYQFTSWKEKTTPNV-ALFVGFVVASREVSKKyeqekDAPVIVHCSDGQGFTGVFVALDIGVRsheesk
. .. | .... .        . .  .|.. .|....|   ..|.  .|.  |. . .|. |.     . ||.|||| | | ||..||...  .      
llkdlgittvlnl......tselellerlgiqylylpwpDhgvpdllellleflefieealke.....ggpvlVHCsaGvgRtgtlvaaylmll......

TSvVDLFEVAKRLRQARCGIISSLQHYNFIYQ
 . |.|.|. ...|..| |.. . ....|.|.
lg.vsleealelvrsqrpgavpnpgqlrflye
0048179 (Phosphotyrosine protein) phosphatases II 9-137 2.4e-14 48.8 In-house 26-139 (144) alignment 
Range on Protein: 9-137
Range on HMM: 26-139/144.0
WETGSGHIVMVNDDqknkETAPPSTREISHYQFTSWKEKTTPNV-ALFVGFVVASREVskkyeQEKDAPVIVHCSDGQGFTGVFVALDIGVrsheesKTS
.. | .... ....       .  .||. .|....|    .|.  .|.  |. . .|.     .|.. ||.|||| | | ||..||... .      |  
kklgittvinltee....yepefleregiqylhlpwpDhgvpdllellleflefieea.....leeggpvlVHCsaGvgRtgtlvaaylmk......klg

vVDLFEVAKRLRQARCGIISSLQHYNFIYQ
 ..|.|. ...|..|.|.. . ....|...
.lsleealalvrsrrpgavpnpgqlrfLle
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 31-136 6e-14 46.9 In-house 175-281 (325) alignment 
Range on Protein: 31-136
Range on HMM: 175-281/325.0
PSTREISHYQFTSWKEKTTPNV-ALFVGFVVASREVSKKYEQ--EKDAPVIVHCSDGQGFTGVFVALDIGVRshEESKTSVVDLFEVAKRLRQARCGIIS
  || .  .|. ||..  ...  | .. ..    .||..     .  .|..||||.| | ||||..|   .   .  . | ||.|.. |.||. |  .. 
GetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysala..kvieesrvdifgfvkklrkdrpsmve

SLQHYNFIY
.   | .||
tvdqyiliy
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 32-136 6.3e-14 46.3 In-house 172-272 (439) alignment 
Range on Protein: 32-136
Range on HMM: 172-272/439.0
STREISHYQFTSWKEKTTPNVALFVGFVVasREVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEesKTSVVDLFEVAKRLRQARCGIISSLQH
  | . ......| .|  |  | .|   .  | .    ..|.  ||.|||| | | ||  .|||| .          ||.  . | ||. |  .. .| .
kertvlqfhyiawpdknvpaqashvldfl..rainsandkeeygpvvvhcsagvGrtGtiialdialeqlk..lenkvdikgivkvlrkqrkqmvqalcq

YNFIY
| |||
yvfiy
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 34-136 4.8e-13 43.8 In-house 137-234 (239) alignment 
Range on Protein: 34-136
Range on HMM: 137-234/239.0
REISHYQFTSWKEKTTPNVALFVgfVVASREVSKkYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKTsvVDLFEVAKRLRQARCGIISSLQHYN
| . .|.|| | .|  |. |  |  .   |...|        | ..||| | | || |. .|  .|  .. ||  ||.|.  | .|. |  .. . ..| 
ryvyqyhftvwpdkgvpqyatav..lglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqakkqkt..vdifnyvkairedrphmvqtseqyv

FIY
||.
fih
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 34-136 4.8e-13 43.8 In-house 136-233 (239) alignment 
Range on Protein: 34-136
Range on HMM: 136-233/239.0
REISHYQFTSWKEKTTPNVALFVgfVVASREVSKkYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKTsvVDLFEVAKRLRQARCGIISSLQHYN
| . .|.|| | .|  |. |  |  .   |...|        | ..||| | | || |. .|  .|  .. ||  ||.|.  | .|. |  .. . ..| 
ryvyqyhftvwpdkgvpqyatav..lglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqakkqkt..vdifnyvkairedrphmvqtseqyv

FIY
||.
fih
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 33-136 2.8e-12 40.7 In-house 88-187 (440) alignment 
Range on Protein: 33-136
Range on HMM: 88-187/440.0
TREISHYQFTSWKEKTTPNVALFVGFVVasREVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRshEESKTSVVDLFEVAKRLRQARCGIISSLQHY
.| . .|.. .| .|  |..|  |  ..  ..|..  |.  ..|..|||| | | ||| .|.|  .|  |  ..  .|.| . . .|. |  .. . ..|
srtlkqyhyqgwpdkgvpkfagpvlkmi..qdvnesqekagngpllvhcsagagrtgviiavdsilr..eakrsdqidifsfinsmrnnrpqmvqtpeqy

NFIY
 |..
afvh
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 32-136 7.2e-11 36.6 In-house 154-252 (267) alignment 
Range on Protein: 32-136
Range on HMM: 154-252/267.0
STREISHYQFTSWKEKTTPNVALFVGFVVasreVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEesKTSVVDLFEVAKRLRQARCGIISSLQH
|..... | .  |. .|  .  |   | .    ..|.  .. . |..|.|||| | .| |. .|  ..     . .|.|.|.  ...|. | |.. ....
sahnvtlyyykkwnintnnkpylkplfgi....laknqlengnrPlvvacsdGvGrsGtflvidsqlerak..tegvsdifdflrkirsqriglvdtker

YNFIY
| .|.
yiyih
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 34-127 1.2e-10 35.6 In-house 183-267 (290) alignment 
Range on Protein: 34-127
Range on HMM: 183-267/290.0
REISHYQFTSWKEKTTPNVALFVGFVVasREVskkyeQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKTsvVDLFEVAKRLRQARCGIIS
  . |..  || .|. .. .| .  ..  | .     ..   ||.|||| | | || |||...|..   . |   .|| .. . ||..| . . 
hklkhlkikswpdksvalstlallrtl..ril.....rkasGpvvvhcsaGiGrtGtfvaievglqilldGke..ldlldlvralrnsrlnsvq
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 34-136 1.4e-10 35.4 In-house 168-270 (287) alignment 
Range on Protein: 34-136
Range on HMM: 168-270/287.0
REISHYQFTSWKEKTTPNV-ALFVGFVVAS-REVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEEskTSVVDLFEVAKRLRQARCGIISSLQH
| .  ... || .|. .     .. ||.   . .  . . ..  |..||.. | | .|...|. . |.  |.  .  ||   |  |||. | ... .   
rvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrled..lGrvdvaavvirlreyraalvqavvq

YNFIY
. ..|
lrlly
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 35-135 2.8e-10 34.8 In-house 159-251 (290) alignment 
Range on Protein: 35-135
Range on HMM: 159-251/290.0
EISHYQFTSWKEKTTPNVALFVGFVVasrevsKKYEqEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKTSVvDLFEVAKRLRQARCGIISSLQHYNF
 . |... .|..  ...  . .  ..      .| .  ...|||||| ||     .. |...|     |.. ||  | .| | ||. |   |.| . . |
tvtHsllkgWnklnvqedtktllsli......qkvk.asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsv.kledvlkalrkqralaitsalelaf

I
.
v
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 32-132 3.4e-10 34.1 In-house 179-271 (301) alignment 
Range on Protein: 32-132
Range on HMM: 179-271/301.0
STREISHYQFTSWKEKTTPNVALFVgfvVASREVSKKYEQekdaPVIVHCSDGQGFTGVFVALDIGVRSHEESKTsvVDLFEVAKRLRQAR-CGIISSLQ
.|| . |||...| .. .|.    .       |. || |.    |..||||.| | .  |.. ..  |  |  .|  ..| |  |.||. | .|.    |
atrtvthyqysewtdrgvPkshael...fdlmelvkksek....PivvhcsaGiGrsvafigteylareveadpt..ieltealkhlrehrwngvqtnsq

HY
 |
ly
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 24-131 1.3e-09 31.9 In-house 178-276 (302) alignment 
Range on Protein: 24-131
Range on HMM: 178-276/302.0
KNKETAPPSTREISHYQFTSWKEKTTPNVALfvgfvvASREVSKKYEQEKdAPVIVHCSDGQGFTGVFVALDIGVRSHeeSKTSVVDLFEVAKRLRQARC
||...     . ..  .|..| .. .|. |       .. .. |  |  |   |.|||| | | || .||.  |.     ||  | || .. . .|| | 
knekkkkkvkktvdilafsawpdhGapkeay......taldilkfcesyk.knvlvhcsaGvGrtGtlvaikyGiqlc..skkkvtdllsivlpvrqcry

GIISSLQH
| . . | 
Gavqdeqq
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 32-127 1.7e-09 32.1 In-house 114-205 (255) alignment 
Range on Protein: 32-127
Range on HMM: 114-205/255.0
STREISHYQFTSWKEKTTPNVALFVGFVVASREVSKkyeqekdaPVIVHCSDGQGFTGVFVALDIG----VRSHEESKTSVVDLFEVAKRLRQARCGIIS
 |... ||... | || .|. |  . ...     ||        .|.|||| | | .  ||  ..     .|| ....|  .|  .. . ||. | . | 
kthtvkhysykGWieknaPelareilnilkvvrdsk........svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraih
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 32-135 1.8e-09 32.0 In-house 174-269 (307) alignment 
Range on Protein: 32-135
Range on HMM: 174-269/307.0
STREISHYQFTSWKEKTTPNVALFVGFVVASrevsKKYEQekdAPVIVHCSDGQGFTGVFVALDIgVRSHEESKTSVVDLFEVAKRLRQARCGIISSLQH
 .| |.|.|.. | .. .|.. |    .. .     .|..    ||.|||| | | .|  ||. . |.    .     |. .. . ||. |   | .   
ksrtiqhlqwenwpdrgvpqinltainllea....vrydt...npvvvhcsaGvGrsGtivaisl.vqdkmiaGinckdmkklveelrsqrhyaiqteaq

YNFI
| ..
ylyl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 63-136 1.3e-08 29.0 In-house 250-337 (350) alignment 
Range on Protein: 63-136
Range on HMM: 250-337/350.0
REVS-KKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRS------------HEESKTSVVDLFE-VAKRLRQARCGIISSLQHYNFIY
  .. . ..... .|..|||| | | ||..|.||  .              . .  . . || . . ..||. |  .. .|. . |||
dlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiY
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 66-137 1.7e-08 28.7 In-house 220-289 (297) alignment 
Range on Protein: 66-137
Range on HMM: 220-289/297.0
SKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVrsHEESKTSVVDLFEVAKRLRQARCGIISSLQHYNFIYQ
| . |. ..|...|||| | | .|| |  |. .      |  . |   . . ||. |  .. .|. ....|.
slraemprnayllvhcsaGvGrsGvvvlsdvil..aklrkkripdvaailsilreqrarlvqtleqfellyd
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 39-136 1.9e-08 28.1 In-house 186-278 (302) alignment 
Range on Protein: 39-136
Range on HMM: 186-278/302.0
YQFTSWKEKTTPnvALFVGFVVASREVsKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESktSVVDLFEVAKRLRQARCGIISSLQHYNFIY
| .| ||.|. |    .   . .  .|  . ... |.....    | |  |.|..| . | . ...  . .   |..| .|. |. .. ||. |...|
yvltnWkqkkvp..vkyaeliktaakv.fakkikadentvivSknGaGRagafltlavaveklqkg..kepnikeivksiRsqRpravdslkQyvsly
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 25-136 4.3e-08 27.5 In-house 158-263 (285) alignment 
Range on Protein: 25-136
Range on HMM: 158-263/285.0
NKETAPPSTREISHYQFTSWKEKTTPNVALFVgfVVASREVsKKYeQEKDAPVIVHCSDGQGFTGVFVALDIG-VRSHEESKtsvVDLFEVAKRLRQARC
| | |      . | |   | .. .|. |  .  .   . | ||  . |. |. |||| | | |  || .|   .|  |. .   ...... . .|  | 
ntedasseplymnhvqvpwwpdqlapedarpm..ielykwv.kkv.npkekpicvhcsagvgrtatfvgidyatirimenpn...iemldivremramrf

GIISSLQHYNFIY
  . |  .. |.|
qavqshmqflfly
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 34-136 6.9e-08 26.5 In-house 188-282 (305) alignment 
Range on Protein: 34-136
Range on HMM: 188-282/305.0
REISHYQFTSWKEKTTPNVALfvgfvvASREVSKKYEQEKdAPVIVHCSDGQGFTGVFVALDIGVRSHEESKTsVVDLFEVAKRLRQARCGIISSLQHYN
  . | |.| | ..  | . |      .| |.       |  |..|||| | | ||  ||..  .    | |  .  . |. | ||. |.  | .  .| 
msvrhlqwtewpdrgvppckl......tslellsairgsk.vpivvhcsagigrtgtivaieyilekiaenkp.cppmpelvkalrdqrafsiqndvqyl

FIY
||.
fih
subfamily_Auxilin_pd Subfamily Auxilin 13-120 2.3e-07 23.7 In-house 48-147 (166) alignment 
Range on Protein: 13-120
Range on HMM: 48-147/166.0
SGHIVMVNDDQKNKETAPPSTReISHYQftsWKEKTTPNVALFvgfVVASREVSKKYEQEKDAPVIVHCSDGQGFTGVFVA-LDIGVRSHEESkTSVVDL
... ...|  |....||..|.| .....   | .. .||.  .   |  .|.. .  ....   |.||| ||.  ..| |. | . .|  .|.  | |.|
pekylvynlsqrtyrtaklssr.vveag...wparraPnLesl...vevcrnlyswlkkdpknvvvvhckDGraasavlvsallvfcrllsep.esavrl

FEVaKRLRQ
| | ||| .
fsv.krlpi
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 33-136 2.9e-07 24.4 In-house 166-262 (281) alignment 
Range on Protein: 33-136
Range on HMM: 166-262/281.0
TREISHYQFTSWKEKTTPNVALFVGfvvasrEVSKKYEqEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEeSKTSVVDLFEVAKRLRQ-ARCGIISSLQH
|| |.|. .  | .   |. .  .       .. .|    . .| ..||| | | .| ..|..| ..|   |. .. |. ..  .||   |.  . .||.
trlithwlwkewpdwqvpessevml......kilrkir.arstppvihcsagvgrsgtlmaveialqsih.shftlpdikqivshlrvtgraasvqtlqq

YNFIY
| .|.
ymliw
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 35-119 2.9e-07 24.5 In-house 177-255 (312) alignment 
Range on Protein: 35-119
Range on HMM: 177-255/312.0
EISHYQFTSWKEKTTPNVAlfvgfVVASREVSKKYEQEKdaPVIVHCSDGQGFTGVFVALDIGVRSH-EESKTSVVDLFEVAKRLR
 . |||..|| ..  |.         | | .|    . |  ||| ||| | | || .. ..  . .     |  | | | . .. |
klnhyqwaswpdhgmpdsc.....dtalrllsavkkdkk..pviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdr
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 66-110 4.1e-07 23.6 In-house 257-301 (349) alignment 
Range on Protein: 66-110
Range on HMM: 257-301/349.0
SKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKTSVVD
 . ..... ....|||| | | |||.| ||. .   |  .   . 
rlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnk
subfamily_ptpA1_pd Subfamily ptpA1 32-96 6.9e-07 23.3 In-house 184-251 (418) alignment 
Range on Protein: 32-96
Range on HMM: 184-251/418.0
STREISHYQFTSWKEKTTPNVALFVG---FVVASREVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDI
 ||.|..||.  | ..  |. .  .    . .. |.       ... |.||||| | | || |..  |
etrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavi
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 78-136 9.2e-07 23.2 In-house 2-58 (69) alignment 
Range on Protein: 78-136
Range on HMM: 2-58/69.0
IVHCSDGQGFTGVFVALDIGVRSHEESKtsVVDLFEVAKRLRQARCGIISSLQHYNFIY
.|||| | | || |.|. . .      |  .||.|.  . .|. |  ..   . | ||.
vvhcssgtgrtgtfiaimvemariksek..lvdifnnvqymrkcrpmmvmneieyifih
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 78-136 1.6e-06 22.4 In-house 1-57 (69) alignment 
Range on Protein: 78-136
Range on HMM: 1-57/69.0
IVHCSDGQGFTGVFVALDIGVRSHEESKtsVVDLFEVAKRLRQARCGIISSLQHYNFIY
.|||| | | || |.|. . .      |  .||.|.  . .|. |  ..     | ||.
vvhcssGtGrtGtfiaimvemariksek..lvdifnnvqymrkcrpmmvmneneymfih
subfamily_hpo-7_pd Subfamily hpo-7 32-127 1.9e-06 22.0 In-house 120-211 (263) alignment 
Range on Protein: 32-127
Range on HMM: 120-211/263.0
STREISHYQFTSWKEKTTPNVALFVGFVVASREVSKkyeqekdaPVIVHCSDGQGFTGVFVALDIG----VRSHEESKTSVVDLFEVAKRLRQARCGIIS
 |... ||... | ||  |. |  .  ..     ||        ...|||| | | .  |.  ..     .|| ....|  .|  .. . ||. | . | 
kthtvkhysykgWiekndpelareilnilkvarnsk........slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraih
subfamily_PTEN_pd Subfamily PTEN 36-132 1.9e-06 23.0 In-house 82-171 (184) alignment 
Range on Protein: 36-132
Range on HMM: 82-171/184.0
ISHYQFTswkEKTTPNVALFVGFVvasREVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKTSVVDLFEvAKRLRQARCGIISSLQHY
...|.|.   ....|.. |.  .|   ....|  |..|.  |.|||  |.| ||| ..  .  . . |.......||. ..| .....  | | . |
vavypfd...Dhnppplelleeiv...ediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfa.eaRtknkkgvtiPsqrRY
DSPc_SM00195 1-27 2.1e-06 22.7 In-house 82-108 (263) alignment 
Range on Protein: 1-27
Range on HMM: 82-108/263.0
MADFWQMVWETGSGHIVMVNDDQKNKE
..|||.||||...  |||......|..
vedFWrmvweekvkiivmlteeeengk
PTPc_SM00194 1-27 2.1e-06 22.7 In-house 82-108 (263) alignment 
Range on Protein: 1-27
Range on HMM: 82-108/263.0
MADFWQMVWETGSGHIVMVNDDQKNKE
..|||.||||...  |||......|..
vedFWrmvweekvkiivmlteeeengk
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1-27 2.2e-06 22.0 In-house 105-131 (297) alignment 
Range on Protein: 1-27
Range on HMM: 105-131/297.0
MADFWQMVWETGSGHIVMVNDDQKNKE
.||||.||..     |||.|||.....
vadfWamvldeqvstivmlnddnerdk
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 29-137 2.7e-06 21.4 In-house 181-281 (305) alignment 
Range on Protein: 29-137
Range on HMM: 181-281/305.0
APPSTREISHYQFTSWKEKTTPNVALFVGFVVASREVSKkyeqekdAPVIVHCSDGQGFTGVFVALDIGVRSHeESKTSVVDLFEVAKRLRQARCGIISS
.  ..| ..|| .  | ..  |   | .  ...   .||        |..|||| | | ||  | |.  .     .   . |   . ...|. |   | .
pgekarkvthyhwidwpdrgvpaadlailellekarpsk.......gpivvhcsagigrtgsvvmleyildql.lagqiiedtdkilqkireqrnnsiqt

LQHYNFIYQ
 . | |..|
daqylfvhq
subfamily_PTPRD_pd Subfamily PTPRD 1-26 2.8e-06 21.2 In-house 104-129 (564) alignment 
Range on Protein: 1-26
Range on HMM: 104-129/564.0
MADFWQMVWETGSGHIVMVNDDQKNK
..|||.||||  |  |||..  . ..
iedFWRmvweqnsstiVmltkleEkg
Y_phosphatase Protein-tyrosine phosphatase 1-26 3.8e-06 21.9 Pfam-A 55-80 (235) alignment 
Range on Protein: 1-26
Range on HMM: 55-80/235.0
MADFWQMVWETGSGHIVMVNDDQKNK
..|||.|||.  .  |||........
iedFWrmvwqekvkvivmltsleekg
Y_phosphatase Protein-tyrosine phosphatase 1-26 3.8e-06 21.9 In-house 55-80 (235) alignment 
Range on Protein: 1-26
Range on HMM: 55-80/235.0
MADFWQMVWETGSGHIVMVNDDQKNK
..|||.|||.  .  |||........
iedFWrmvwqekvkvivmltsleekg