Gene NvecPTP-sf4-1 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily NvecPTP-sf4
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP058_AA protein Get Run
NvecP058_AA_0-222 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1-222 3.1e-155 509.4 In-house 16-237 (237) alignment 
Range on Protein: 1-222
Range on HMM: 16-237/237.0
DHSRVMLRGAGSGCDYINATYIKGFDGTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQPATYGVLTVSLKKKEEFSD
|||||.|.|||||.|||||||.||||||||.||||||||||||||||||||||||||||||||||||||||||.|||||||||.||||||||||||||||
dhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltvslkkkeefsd

YTVRSLLLSKQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHVPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVYAIE
||||||||||..|||||||||||||||||.||||||||||||||||||||||||..|||||||||||||||||||||||||||||||||||||||||.||
ytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysie

EDRPYIIQTKDQYVFIHQTILE
||||||||||||||||||||||
edrpyiiqtkdqyvfihqtile
subfamily_PTPRD_pd Subfamily PTPRD 1-222 2.1e-104 345.2 In-house 61-279 (564) alignment 
Range on Protein: 1-222
Range on HMM: 61-279/564.0
DHSRVMLRG--AGSGCDYINATYIKGFDgTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDqPATYGVLTVSLKKKEEF
|||||.|.   . .|.|||||..|.|.. ..|.|||.||||.....|||.|||....|.||||| | | .. |||.|||... ..||| |||.|...||.
dhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeel

SDYTVRSLLLsKQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPhvPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVYA
.||..|.. | |. . .|.| ..|..|||||..|||.....||...... . ..  |..||...||||||||||.|.||||||...||.|.||||.|| |
adyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne..pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvka

IEEDRPYIIQTKDQYVFIHQTILE
. ..|....||..||.|||..|||
lrkqRnamVqteeQYiFiheaile
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1-222 1.7e-86 284.2 In-house 21-239 (239) alignment 
Range on Protein: 1-222
Range on HMM: 21-239/239.0
DHSRVMLRGA--GSGCDYINATYIKGFDGTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPstDQPATYGVLTVSLKKKEEF
|||||.|         |||||.|.. .||.||.|||.|| .| |. |||.|.|||.  ||||||||||| . |||||||  |  . |  | |.|.| | |
dhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp..dstskycnlrvtlrktevf

SDYTVRSLLLSKQGTLkEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSphVPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVYA
.|| .|....|. |   | | ..||.|| || .|||| ..|.| .|..| . |  .| . ||.||||||||||| ||||||||||||..| |||.||| |
adyiirtfvmsqvgqt.eeryvyqyhftvwpdkgvpqyatavlglrrkitkds..lpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvka

IEEDRPYIIQTKDQYVFIHQTILE
| ||||...|| .|||||| ..||
iredrphmvqtseqyvfihlavle
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1-222 1.7e-86 284.2 In-house 20-238 (239) alignment 
Range on Protein: 1-222
Range on HMM: 20-238/239.0
DHSRVMLRGA--GSGCDYINATYIKGFDGTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPstDQPATYGVLTVSLKKKEEF
|||||.|         |||||.|.. .||.||.|||.|| .| |. |||.|.|||.  ||||||||||| . |||||||  |  . |  | |.|.| | |
dhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp..dstskycnlrvtlrktevf

SDYTVRSLLLSKQGTLkEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSphVPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVYA
.|| .|....|. |   | | ..||.|| || .|||| ..|.| .|..| . |  .| . ||.||||||||||| ||||||||||||..| |||.||| |
adyiirtfvmsqvgqt.eeryvyqyhftvwpdkgvpqyatavlglrrkitkds..lpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvka

IEEDRPYIIQTKDQYVFIHQTILE
| ||||...|| .|||||| ..||
iredrphmvqtseqyvfihlavle
0046845 (Phosphotyrosine protein) phosphatases II 1-222 7.9e-83 273.4 In-house 41-272 (284) alignment 
Range on Protein: 1-222
Range on HMM: 41-272/284.0
DHSRVMLRGAGSG---CDYINATYIKGFD----GTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQPATYGVLTVSLK
||||| |.  ...   .||||| |..|.|     ..|..||.||||.....|||.|||.....||||||.|.| .  ||.||||..... ||| .|| |.
dhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtll

KKEEFSDYTVRSLLLSKQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHVPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKK---VV
..|...||||| | |.. |. .|.| ......||||..|||.... ||.| . . .  ...|..|| ..|||||||||| |...| .|.| ....   .|
seevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgv

DIYNYVYAIEEDRPYIIQTKDQYVFIHQTILE
|....|. . | ||. .|| .||.|.....||
dvleavkrlreqRpgmvqtleqyrfvyealle
0050432 (Phosphotyrosine protein) phosphatases II 1-222 1.3e-82 272.9 In-house 81-297 (308) alignment 
Range on Protein: 1-222
Range on HMM: 81-297/308.0
DHSRVMLrgaGSGCDYINATYIKGFD-GTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPST--DQPATYGVLTVSLKKKEE
||||| |   ..|.||||| |..|.. . |...||.||||.....|||.|||.....|||||| |.| .  ||.||||..  ... .|| .|| |.. |.
dhsRVkl...degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev

FSDYTVRSLLLSKQGTLkEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSphvpKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVY
..||||| | |.. |.  |.| ......|.||. |||.....||.| . . ..     ..|| ..|||||||||| |...| .|.| .... ||....|.
lddytvrtleltnlgdg.esrtvthfhytnWpdhgvPpspeilldflelvrksl....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavk

AIEEDRPYIIQTKDQYVFIHQTILE
 . | ||. .||..||.|.....||
klReqRpgmvqtpeqylflyralle
subfamily_PTPRB_pd Subfamily PTPRB 1-221 8.3e-82 269.5 In-house 64-282 (293) alignment 
Range on Protein: 1-221
Range on HMM: 64-282/293.0
DHSRVML--RGAGSGCDYINATYIKGFDgTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQPATYGVLTVSLKKKEEF
||||| |      || ||||| ||.|.  .|. .||.|||| .. ||||.|||..|.|.||||| |.|.   ||..|||....| .|| ..|.|...|| 
dhsrvkLaalkdesgsDYinanyipgyn.sprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeel

SDYTVRSLLLSKqgtLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHVPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVYA
.|...|.|...|    || | ..||.|||||  |||..|..||.| ... ..  .  ...| ..||||||||||.|. .| .|.. .|. .|||.  |..
edwvirelkiek...ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivae

IEEDRPYIIQTKDQYVFIHQTIL
. |.| ...||..||.||||..|
lReeRnllvqtekqYifihqcvl
0051299 (Phosphotyrosine protein) phosphatases II 1-222 8.8e-81 266.8 In-house 62-284 (288) alignment 
Range on Protein: 1-222
Range on HMM: 62-284/288.0
DHSRVMLRGAGS--GCDYINATYIKGFDGTPKtYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPStDQPATYGVLTVSLKKKEEF
||||| |.  ..  |.||||| ||.|.. . | .||.||||.....|||.|||.....||||||.|.| .  ||.||||. ... ||| .|| |.. |..
dhsRVkLsvldgvegsdYinAsyidgynlkrk.fIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevl

SDYTVRSLLLSKQG---TLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPhvPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNY
.||||| | ... .     .|.| ......|.||. |||. . .||.| . ...  .  ...|| ..|||||||||| |...| .|.| .....||....
ddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala..sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvlea

VYAIEEDRPYIIQTKDQYVFIHQTILE
|  . | ||...|| .||.|.....||
vkrlreqRpgmvqtpeqyrfvyealle
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1-222 9.6e-79 259.7 In-house 69-288 (298) alignment 
Range on Protein: 1-222
Range on HMM: 69-288/298.0
DHSRVMLRG--AGSGCDYINATYIKGFDGTPkTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTdQPATYGVLTVSLKKKEEF
|.|||.|.   |   .|||||.......|.. ..||.|.||...  |||.||..|. ..||||| | | ...|.|.|||.. . .||| .||||..||||
dssRvvLekedadeesdYiNAsflhaykgrn.afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPde.gketygeitvsllskeef

SDYTVRSLLLSKQGTLkEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINrSPHVPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVYA
.|..|| | .||. .  . | ..| .||||| .|||... ..| .....   |..  .  | |..|||||||.| | .||..| ..|...|||....| .
adlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkv

IEEDRPYIIQTKDQYVFIHQTILE
. ..|| ..||..|||||.. .||
lRkkrpgavqteeqYvfiyeavle
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1-222 1.7e-78 258.9 In-house 59-278 (318) alignment 
Range on Protein: 1-222
Range on HMM: 59-278/318.0
DHSRVMLRG--AGSGCDYINATYIKGFDgTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPStDQPATYGVLTVSLKKKEEF
||.|| |.      | ||||| || |.    |.|||||.||   ..|||.|||. ...|||||| . |    |.|.|||| ... .|| |.| ||.. |.
dhtrvkLqmlegeegsDyinanyidGyr.rkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPs.kgsrsygklvvelkeevel

SDYTVRSLLLSKQGTlKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIiNRSPHVPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVYA
|||..|.. ...... .|.| ..||..|||| .|||...| || . ... ..  . .. || ..||||||||||.|...|..|...|. ..||....|  
sdyvlrefkvtrtee.eesrqvrqyhytsWpdegvpesgaslldlvrqv.skaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkq

IEEDRPYIIQTKDQYVFIHQTILE
. | |. ..||.|||.||....||
lreqrnlmvqtedqyefiydvlle
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1-222 2.4e-78 257.8 In-house 22-240 (250) alignment 
Range on Protein: 1-222
Range on HMM: 22-240/250.0
DHSRVMLRGAG--SGCDYINATYIKGFDGTpKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELkCHQYWPsTDQPATYGVLTVSLKKKEEF
|.|||.|        .|||||....|.|.. |..||.||||...  |||.||..|| ..||||| | | ..  .||||| .... .|| .||||..||||
dssrvvLekekgdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP.vekaekyGdvtvsllskeef

SDYTVRSLLLSKQGTLKEvRLIHQYQFTSWPHRGVPQQTAALLRFRKNIiNRSPHVPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVYA
.|||.| | |||.   .| |.. |..|..|| .|||... | | ..|.. ..|    ...| |..|||||||.| |..|||.| ..|..||||..... .
adytkrklklskakkade.rivrqlhfvvWPdkgvPevatavLellkkv.qasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikv

IEEDRPYIIQTKDQYVFIHQTILE
. .|||  .....||||... ||.
lrkdrphavesleqyvfvyeiilk
0036941 (Phosphotyrosine protein) phosphatases II 1-222 2.9e-77 255.2 In-house 52-275 (297) alignment 
Range on Protein: 1-222
Range on HMM: 52-275/297.0
DHSRVMLrgAGSGCDYINATYIKGFDGTPKtYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPST-DQPATYGVLTVSLKKKEE--
||.|| |   ..|.||||| |..|.| . | .||.||||.....|||.|||.....|||||| |.| .  ||.||||.. ... ||| .|| |.. |.  
dhtRVkl..ddegsdYinAsyvdgydlkrk.fIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvl

FSDYTVRSLLLSKQGTLkEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHVPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAK---EKKVVDIYN
..|||.| | ... |.  |.| ......|.||. |||. .| ||.| . . .. .. |..|| ..||||||||.| |...| ||.| .   . . |||..
lddytlrtlevtdtgng.esrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdile

YVYAIEEDRPYIIQTKDQYVFIHQTILE
.|  . | || ..|| .||.|.....||
avkklReqRpgavqtleqyrflyealle
0047943 (Phosphotyrosine protein) phosphatases II 1-222 6.3e-77 254.0 In-house 51-270 (273) alignment 
Range on Protein: 1-222
Range on HMM: 51-270/273.0
DHSRVMLrgAGSGCDYINATYIKGFDGTPKtYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQ--PATYGVLTVSLKKKEEF
||||| |   ..|.||||| |..|.. ..| .||.||||.....|||.|||.....|||||| |.| .  ||.||||.. .  . ||| .|| |.. |..
dhsrvkl..gdggsdyinAsyvdgynlkrk.fiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetk

SDYTVRSLLLSKQGTLKeVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHVPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVYA
.||||| | |.. || . .| ......|.||  |||.... ||.| . . .   ..|..|| ..|||||||||| |...| .|.| .... ||....|. 
ddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkl

IEEDRPYIIQTKDQYVFIHQTILE
. . ||...|| .||.|.....||
lrsqRpgmvqtpeqyrflyealle
0045450 (Phosphotyrosine protein) phosphatases II 1-222 1.9e-75 249.8 In-house 68-302 (307) alignment 
Range on Protein: 1-222
Range on HMM: 68-302/307.0
DHSRVMLRGAG---SGCDYINATYI--------KGFDGtPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQPATYGVLT
||.|| |   .   ...|||||.|.        .|.|  ....||.||||.....|||.|.|.....||||||.|.| .  ||.||||..... ||| .|
dhtRVklssldgsledsdYiNAsyvrvpllllldgydl.krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnft

VSLKKKEEFSDYTVRSLLLSKQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHVPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKV
| |...|. ..|||| | ..  .  .|.| ......|.||. |||. .. ||.| . . .   . ||.|| ..|||||||||| |.... |||| .. ..
vtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegt

---VDIYNYVYAIEEDRPYIIQTKDQYVFIHQTILE
   ||... |  . | || ..|. .||.|... .||
lldvdlleavkllreqRpgavqnpeqyrflyealle
0040438 (Phosphotyrosine protein) phosphatases II 1-222 2.5e-75 249.0 In-house 56-274 (317) alignment 
Range on Protein: 1-222
Range on HMM: 56-274/317.0
DHSRVMLRGAGS--GCDYINATYIKGFDGTPKtYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPStDQPATYGVLTVSLKKKEEF
||||| |   |.  ..||||| |..|.. ..| .||.||||.....|||.|||.....|||||| | | .  ||.||||. ... ||| .|| |.. || 
dhsRVkLsplggdldsdYInAsyvdgpnlkrk.fIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeel

SDYTVRSLLLSKQGTLkEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPhvPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVYA
...|.| | ... |.  |.| ......|.||. |||. .  ||.| . . .  .  ...|| ..|||||||||| |.... ||.| .... ||... |. 
agitlrtlevedlgds.esrtvthfhytgWpdhgvppspdllldfleavreale..dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavke

IEEDRPYIIQTKDQYVFIHQTILE
. | ||...|| .||.|... .||
lreqRpgavqtpeqyrflydalle
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1-221 1e-74 246.2 In-house 60-276 (288) alignment 
Range on Protein: 1-221
Range on HMM: 60-276/288.0
DHSRVMLRG--AGSGCDYINATYIKGfDGTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQPATYGVLTVSLKKKEEF
|. || |..   ..| |||||.||.| ..  |.|||.|||| .. .|||..|...| | |||||.|.||.. ||..|||..|.|  || .|| |....| 
DekrvklkkleeeagaDYinasyidg.ekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskel

SDYTVRSLLLSKQGTlkeVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHVpkSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVYA
 |...|.||| |..|    . |.|||...||  |||...| || ..... . ..    .|| |.||||||||||.|...||.. . .|....|. . |  
edfvlrklllekkkt...eleitqyqylaWpdhgvPeskapllellrqvkvanqad..tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvak

IEEDRPYIIQTKDQYVFIHQTIL
. . |. ..||. ||.||....|
lRkqRallvqtlkqYefiyevll
Y_phosphatase Protein-tyrosine phosphatase 1-222 1.1e-74 246.1 Pfam-A 14-235 (235) alignment 
Range on Protein: 1-222
Range on HMM: 14-235/235.0
DHSRVMLRGAGSGCDYINATYIKGFDgTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWP-STDQPATYGVLTVSLK-KKE-E
|..|| |.| .. .||||| |.||.. ..|..||.||||.|...|||.||||||..|||||| | | .. ||.|||| ..... ||| ..| || |.. .
dktrvklkgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekeked

FSDYTVRSLLLSKQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSphVPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVY
 ..||.| | |.|... .| | ..|...|.||..|||... .||.. ... ...   .|||| ..||||||||||.|...|..|.|..... ||....| 
ekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivk

AIEEDRPYIIQTKDQYVFIHQTILE
 . . || ..|. .||.|....|||
elRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 1-222 1.1e-74 246.1 In-house 14-235 (235) alignment 
Range on Protein: 1-222
Range on HMM: 14-235/235.0
DHSRVMLRGAGSGCDYINATYIKGFDgTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWP-STDQPATYGVLTVSLK-KKE-E
|..|| |.| .. .||||| |.||.. ..|..||.||||.|...|||.||||||..|||||| | | .. ||.|||| ..... ||| ..| || |.. .
dktrvklkgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekeked

FSDYTVRSLLLSKQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSphVPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVY
 ..||.| | |.|... .| | ..|...|.||..|||... .||.. ... ...   .|||| ..||||||||||.|...|..|.|..... ||....| 
ekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivk

AIEEDRPYIIQTKDQYVFIHQTILE
 . . || ..|. .||.|....|||
elRkqRpgmvqsleqYiflykaile
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 4-221 5e-74 244.2 In-house 62-280 (305) alignment 
Range on Protein: 4-221
Range on HMM: 62-280/305.0
RVMLRGAGS--GCDYINATYIKGFDGTpKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQ-PATYGVLTVSLKKKEEFSD
|..|.   |    |||||.|..|...  |.||.|||||..  .|||.....|| |.|||||.|.||.. ||.|||| . . .  .| ..| || ....||
riiltekeslddsdyinasyvdgykrk.kkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasd

YTVRSLLLSKQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHvPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVYAIE
|. | | .|.. . || | . |||.|.||  ||||....||.. |.. ..  .  |  | ..||||||||||.|...| .| ..|. .|||..... .. 
yieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkk.dkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlR

EDRPYIIQTKDQYVFIHQTIL
. |....||.|||||.|. . 
skrmkmvqtldqYvflhdald
0039614 (Phosphotyrosine protein) phosphatases II 1-221 2.4e-73 242.5 In-house 69-286 (297) alignment 
Range on Protein: 1-221
Range on HMM: 69-286/297.0
DHSRVMLRGAGS---GCDYINATYIKGFDGTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNElKCHQYWPSTDQpaTYGVLTVSLKKKEE
||||| | . ..   ..||||| |..|.| .....||.||||.....|||.|||.....|||||| |.| .  ||.||||.. .  ||| .|| |.| |.
dhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkveh

FSDYTVRSLLLSKqgtLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHVPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVY
 ..|||| | ...    .|.| ....|.|.||. |||. .. ||.| . . ..  . ||.|| ..|||||||||| |.... ||.| .... ||... | 
ldgytvrtlevtn...ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavk

AIEEDRPYIIQTKDQYVFIHQTIL
 . | ||...|| .||.|... .|
elreqRpgavqtpsqyrflydall
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1-222 2.7e-73 241.8 In-house 61-281 (319) alignment 
Range on Protein: 1-222
Range on HMM: 61-281/319.0
DHSRVMLRGA--GSGCDYINATYIKGFDGTpKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTdQPATYGVLTVSLKKKEEF
|..||.|       | |||||..| |..   . .||.|.|||   .|||.|||.|..|..||||.| |  ..|...|||.. .. .|| |.| |...|| 
drtrvvlseldgvegsdyinasfidgyqer.ekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpee.nfeeyGrlivtleeeeel

SDYTVRSLLLSKQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIiNRSPHVPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVYA
.|| .| | | |. .  | | . ..|.|.||  .||... .|| . |.| ..| . ..||| ..|||||||||| |.|.|||| . ||  |.|....|  
edyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkri.rksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsr

IEEDRPYIIQTKDQYVFIHQTILE
.   |. ..|...|| ||....||
lRtqRnimvqrpeqYkfiyealle
0043336 (Phosphotyrosine protein) phosphatases II 1-221 3.1e-72 238.7 In-house 58-274 (278) alignment 
Range on Protein: 1-221
Range on HMM: 58-274/278.0
DHSRVMLRGAGSG--CDYINATYIKGFDGTPKtYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPstDQPATYGVLTVSLKKKEEF
||||| |   |.   .||||| |..|.. ..| .||.||||.....|||.|||......|||||.| | .  ||.||||  ... ||| .|| |.| |..
dhsrvklsllggdldsdYinAsyvdgynvprk.fiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehl

SDYTVRSLLLSKQGTLKEvRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPhvPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVYA
.||||| | ... |. .. | ...|....||. ||| ... ||.| | .... .  ...|| ..|||||||||| |.... .|.|..  . ||... |  
ddytvrtlevtnlgdges.rtvthyhylgwpdhgvpeslsllldflkavreale..dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavke

IEEDRPYIIQTKDQYVFIHQTIL
. | || ..|| .||.|... .|
lreqRpgavqtpsqyrflyeall
subfamily_PTPRG_pd Subfamily PTPRG 1-222 4.9e-72 237.9 In-house 60-285 (563) alignment 
Range on Protein: 1-222
Range on HMM: 60-285/563.0
DHSRVMLRGAGS---GCDYINATYIKGFDgTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPStDQPATYGVLTVSLKKKEE
|.||| |..        ||||| ||.|.    | .||.||||.. .||||.|.|... ..|||.| | | .  ||..|||. |.. |||.|.| |...| 
drsRvklsplpgkkkklDYinAnyidGyq.kskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeev

FSDYTVRSLLLSK----QGT-LKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIinRSPHVPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDI
.. ||||.| . .    ..   ....|. ||..|.||  |||....  | | |       .  . || ..||||||||||...|.|..|.| .....|..
lalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks..saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnv

YNYVYAIEEDRPYIIQTKDQYVFIHQTILE
.. .  |.  |....||..||.|.|...||
fgflkhiraqRnflvqteEqYiflhdalle
DSPc_SM00195 1-222 5.1e-71 234.4 In-house 39-260 (263) alignment 
Range on Protein: 1-222
Range on HMM: 39-260/263.0
DHSRVMLRGAG--SGCDYINATYIKGFdGTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPST-DQPATYGVLTVSLKKKEE
||.|| |      .| ||||| ||||    .|.|||.||||.| ..|||.|||.||...|||||   | .. ||..|||.. ... |.| ..| |...|.
dhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevek

FS-DYTVRSLLLSKQGTlKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHVpkSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYV
 . ....| | |.|.|. .| | ..|||...||..|||..|  .|.. . . ... .   ||| ..||||||||||.|..|| .|.. .|.| ||| . |
kkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeiv

YAIEEDRPYIIQTKDQYVFIHQTILE
 .. . || ..||..|| ||...|||
kelRkqRpgmvqtleqYlfiyeaile
PTPc_SM00194 1-222 5.1e-71 234.4 In-house 39-260 (263) alignment 
Range on Protein: 1-222
Range on HMM: 39-260/263.0
DHSRVMLRGAG--SGCDYINATYIKGFdGTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPST-DQPATYGVLTVSLKKKEE
||.|| |      .| ||||| ||||    .|.|||.||||.| ..|||.|||.||...|||||   | .. ||..|||.. ... |.| ..| |...|.
dhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevek

FS-DYTVRSLLLSKQGTlKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHVpkSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYV
 . ....| | |.|.|. .| | ..|||...||..|||..|  .|.. . . ... .   ||| ..||||||||||.|..|| .|.. .|.| ||| . |
kkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeiv

YAIEEDRPYIIQTKDQYVFIHQTILE
 .. . || ..||..|| ||...|||
kelRkqRpgmvqtleqYlfiyeaile
subfamily_PTPN6_pd Subfamily PTPN6 1-220 1.1e-70 233.1 In-house 67-293 (306) alignment 
Range on Protein: 1-220
Range on HMM: 67-293/306.0
DHSRVML-RGAGSGCDYINATYIK-GFDGTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQPATYGVLTVSLKKKEEF
||.||.| .   .| ||||| |||  . |. |.|||.|| ||.   |||.|||||.. ||||.|  .| .. || .|||.. .  .||...|.  .... 
DhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksl

SDYTVRSLLLSKQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHVP--KSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKV---VDIY
.||..|.|..||. . || | ..||.|.|||  |||... |.| | ... ... ..   ..|| ..|||||.|||| |.|||..|.. ..|..   .||.
adYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiq

NYVYAIEEDRPYIIQTKDQYVFIHQTI
. |  . | |  ..||..|| |....|
klvksvreqrsglvqteqqykfvykai
subfamily_PTPRA_pd Subfamily PTPRA 1-222 7.4e-70 230.4 In-house 71-293 (330) alignment 
Range on Protein: 1-222
Range on HMM: 71-293/330.0
DHSRVMLRGA-G-SGCDYINATYIKGFDGTpKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPStDQPATYGVLTVSLKKKEEF
|.|||.|    |    |||||..|.|.    ...||||||.| . .|||.|.|. | . ||||| | | .| ||.||||. .   ||| ..|....... 
dfsrvilsvkeGveesdyinasfidGykek.dkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPd.eGlvtyGnirvevedetvl

SDYTVRSLLLSKQGT---LKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHvpKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNY
 ||||| .|. ...     |..||..|. |||||. ||| ..  .|.. |.. .  .   ..|| ..|||||||||| |.|.||.| . | ...||... 
vdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqq..sagpivvhcsaGvGrtGtfivldavlervkaerkvdvfef

VYAIEEDRPYIIQTKDQYVFIHQTILE
|  .   || ..||. ||.||....||
vkrlrlqrpqmvqtdeqyefiykvlle
0045098 (Phosphotyrosine protein) phosphatases II 1-221 2.7e-69 228.9 In-house 46-269 (278) alignment 
Range on Protein: 1-221
Range on HMM: 46-269/278.0
DHSRVMlrgagsgcDYINATYIKGFdgtPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPStDQPATYGVLTVSLKKKEEFSD
|||||         |||||.||.|.   ||..||.||||.| ..|||.|.|.....||||||.|.|..  ||.||||. ... ||| .|| |.. |...|
dhsrVk........dYINAsyidgy...pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe.ggsltygdftvtllseevldd

YTVRSLLLSKQ---GTLKEVRLIHQYQFTSWPHRGVPQQT--AALLRFRKNIINRSP-----------HVPKSGPWIIHCSAGVGRTGIFLVIDAMLRQA
||.| ||.       .  | | ........||  ||| ..  . .|.. . | ..             . ...|| ..|||||||||| . ... ||.. 
ytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell

keKKVVDIYNYVYAIEEDRPY-IIQTKDQYVFIHQTIL
  ...||....|  . . ||. ..|...||.|... .|
..eggvdlleavkelrsqRpglavqnleqyrflyefll
0040439 (Phosphotyrosine protein) phosphatases II 1-221 2.8e-69 228.8 In-house 24-243 (249) alignment 
Range on Protein: 1-221
Range on HMM: 24-243/249.0
DHSRVMLRGAGS--GCDYINATYIKGFDGTPKtYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPStDQPATYGVLTVSLKKKEEF
||||| |   ..  ..||||| ||.|.. ... .||.||||.....|||.|.|.....|||||| | | .  ||.||||. ... .|| .|| |.. |..
dhsrvklsilpglflsdyinAsyidgyyikrr.fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.ggsleygdftvtllsvevk

SDYTVRSLLLSKQgTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHVPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVYA
.||||| | |..    .|.| ....|.|.||. |||. .. ||.| . . .   . ||.|| ..||||||||||.|.... ||.| .... ||....|  
ddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkl

IEEDRPYIIQTKDQYVFIHQTIL
. . ||...|. .||.|... .|
lrsqRpgavqnpeqyrflyeall
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1-222 5.2e-69 227.5 In-house 54-274 (281) alignment 
Range on Protein: 1-222
Range on HMM: 54-274/281.0
DHSRVML--RGAGSGCDYINATYIKGFDGtPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQPATYGVLTVSLKKKEEF
|..|| .    . . .||||| ...|..| .| |||.|||. .|...||||||..| |.|||.|  ||.. ||||.|||  ..  .|| .||. ...|| 
DatrvkvtpneenkntDYinanfvpgykg.ekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeek

SDYTVRSLLLSKQGtlKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHvPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKE-KKVVDIYNYVY
. |  | . |....   | | ..| ..|.||  |||..|..|| |||.. . . .  .  | .||||||||||| .. .| ....... .. .|. . | 
atyierkfkleres..getreveqlaytaWPdhGvPattkellefrkevlkltek.ktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavva

AIEEDRPYIIQTKDQYVFIHQTILE
 . ..| ...||  || |.....|.
elrkernlmvqtvvqyefvykavld
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 11-222 7.6e-67 220.4 In-house 69-275 (315) alignment 
Range on Protein: 11-222
Range on HMM: 69-275/315.0
GSGCDYINATYIKGFDGtPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPS-TDQPATYGVLTVSLKKKEEFSDYTVRSLlLS
    |||||.|||..|   |.|||.||||..| ||||.||.||| . |||.| . ||. .|| ||||    . . .| . |.| . |  .| ..| |   
sPdsdyinasyiksvdd.dkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vt

KQGtlKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRspHVPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVYAIEEDRPYIIQT
...  .| | . |.||| ||..||..||..||.. |..     . .|  . ..||||||||||... || .. |.|....||..|.|  . ..|||..||
rks..eesrtvtqfqftewPdkGvdkqtssllklikevkad..ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqt

KDQYVFIHQTILE
...| ||....||
eeeyafiydavle
0042113 (Phosphotyrosine protein) phosphatases II 1-221 2.3e-66 219.0 In-house 22-240 (245) alignment 
Range on Protein: 1-221
Range on HMM: 22-240/245.0
DHSRVMLRGAGSG--CDYINATYIKGFDGTPKtYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPStDQPATYGVLTVSLKKKEEF
||.|| |   |.   .||||| |..|.. ||| .||.||||.....|||.|.|......||||| . | .  ||.||||. ... ||| .|| |.. | .
dhtrvklspdggdldsdyinasyvdgyritpk.fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.gesltygdftvtllseehl

SDYTVRSLLLSKQgTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHvPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVYA
.||||| | ...    .|.| ...|....||. |||  .. ||.| . . .     ...|| ..|||||||||| |.... ||.|... . |.... |. 
ddytvrtlevtnl.gddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavke

IEEDRPYIIQTKDQYVFIHQTIL
. . || ..|| .||.|... .|
lrsqRpgavqtpsqyrflyeall
subfamily_PTPRK_pd Subfamily PTPRK 1-222 2.7e-66 218.5 In-house 56-275 (314) alignment 
Range on Protein: 1-222
Range on HMM: 56-275/314.0
DHSRVMLRGAGSG--CDYINATYIKGFDgTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQPatYGVLTVSLKKKEEF
|.|||.|         |||||..| ..   |. .|..||||..   |||..|..|.|. ||||| |.|   .|| .|||   .   || . | | . |  
drsrvflitidgdpssdyinaalidsyk.rpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev..ygdikvelvetell

SDYTVRSLLLSK-QGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHvpKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVY
... || . ..| . . .|.|...|.||..||. .||..  .||.. ... . ...  . |. ..||||| ||||.|..|| .|  .....|||..| | 
aelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee..eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavk

AIEEDRPYIIQTKDQYVFIHQTILE
.. . .. ...|..||.||.. |||
tlrsrkvnmveteeqykfiydvile
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 12-222 2.9e-66 218.6 In-house 69-274 (515) alignment 
Range on Protein: 12-222
Range on HMM: 69-274/515.0
SGCDYINATYIKGFDGtPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPS-TDQPATYGVLTVSLKKKEEFSDYTVRSLLLSK
   ||.||.||..||   |.|||.|||...| ||||..|.||. . |.|.| | ||.  || .|||    .   .| . |.|   |  .. . | | . |
Phsdyfnasyipsfdn.dkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlk

QGTlkeVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIinRSPHVPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVYAIEEDRPYIIQTK
.     .| . |..|| ||..|||..| .||.. |..  .. |   . | ||||||||||||... || .. .||. ..||..|.|  | ..|||..||.
gdd...srtvtqfhfteWPdkGvpkhtssllklikev..kadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtq

DQYVFIHQTILE
.|| ||....||
eqyafiygavle
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 2-221 9.5e-66 216.7 In-house 42-265 (274) alignment 
Range on Protein: 2-221
Range on HMM: 42-265/274.0
HSRVMLRGAGS---GCDYINATYIKGFDGTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQP---ATYGVLTVSLKKK
.|||.|. . |     .|||| ||||.|.. |.|.|.|||| .  .|||.|..||...|||||| | | || ||..|.| . .     .|| . .  .|.
nsrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikveki

EEFSDYTVRSLLLSKQGTLKEvrlIHQYQFTSWPHRGVPQQTAALLRFRKNIIN-RSPHVPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYN
 |  ||.||.|.|...   ..   .. | .|.|| . .|... .||.. ... . |. .  | .| ..|||||.||||.|. |.  .|| .|..|||. .
verndysvrklvlkylerers...vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlk

YVYAIEEDRPYIIQTKDQYVFIHQTIL
 |  .  ||  ..||..|| .||... 
ivcnlrldrGGmvqtseqyelihralc
0037934 (Phosphotyrosine protein) phosphatases II 1-221 6.8e-64 211.0 In-house 23-239 (243) alignment 
Range on Protein: 1-221
Range on HMM: 23-239/243.0
DHSRVMLrgagSGCDYINATYIKGFDgtpkTYIAAQGPLESSCDD----FWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPstDQPaTYGVLTVSLKKKE
||||| |    .|.||||| .|....    ..|| ||||.....|    ||.|.|.....|||||| |.| . .||.||||  ..  ||| .|| |.. |
dhsrvkl....egsdyinanliyvtp....rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gev.tygdftvtllsee

EFSDYTVRSLLLSKQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPH------VPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAkekKvV
...||||| |||.  .. ...||...|....||. |||. .. ||.| . ...           ...|| ..|||||||||| ..... ||..    . |
hlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll...g.v

DIYNYVYAIEEDRPY-IIQTKDQYVFIHQTIL
|....|  . | ||. ..|| .||.|... .|
dleeavkllreqRpgkavqtpsqyrflyeall
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1-222 1.9e-63 209.3 In-house 62-277 (315) alignment 
Range on Protein: 1-222
Range on HMM: 62-277/315.0
DHSRVML--RGAGSGCDYINATYIKGFDgTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPstDQPATYGVLTVSLKKKEEF
|.||| |      ...||.||..|.|..  .. |||||||. .| .|||..|..|... |||||.|.||.. |. .|||  |.  .|| .||..|..| .
dksrvqlpllendphsdyvnanfidGyn.kkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywp..dkkviyGkitvtrkseevn

SDYTVRSLllsKQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRspHVPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVYA
..||||.|        ...| . |...||||  |||. | .|. . ...     |  . |. ..|||||||||| |. .||.| ||. ....|.||..  
teytvrtl...svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqh..htnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitg

IEEDRPYIIQTKDQYVFIHQTILE
. . |  ..|. .|| ||....||
vrqnrikmvqvaeqyqfiydalle
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 2-222 3.7e-63 208.8 In-house 75-289 (319) alignment 
Range on Protein: 2-222
Range on HMM: 75-289/319.0
HSRVMLRGA--GSGCDYINATYIKGFDgTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTgliegnELKCHQYWPSTdQPATYGVLTVSLKKKEEFS
...| |.      . |||||....|.   .. ||||||||. . .|||.|.|. .|| ||.||      . || ||||      ...   |...  || .
knvvklerliGeefsdyinasfvtGyq.rkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplk.ivikeerfkvkvdsveeta

DYTVRSLLLSKQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHVPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVYAI
.|.||.. ||..|  |..| |.|. |  ||. |||.... |.|. |..     .  .  . ..||||||||||...|.|..| . ||.| ||.||.|  .
eyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdl

EEDRPYIIQTKDQYVFIHQTILE
 ..|. ..|   || ||. ..||
rqqrntlvqdlvqykfiysalle
subfamily_PTPN3_pd Subfamily PTPN3 1-221 4.7e-63 207.7 In-house 54-272 (280) alignment 
Range on Protein: 1-221
Range on HMM: 54-272/280.0
DHSRVMLRGAGSgcDYINATYIK-GFDG--TPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQPATYGVLTVSLKKKEE
|. ||.|. . .  ||||| |..   ..  . . |||.||||.... |||||||..|.|.||||| |.|    |||||||.|..  .|| ..| ..|..|
datrvklkeset..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPetedeleygefsvkcekede

FSDYTVRSLLLSKQGTlKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIinRSPHVPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVY
 . | .| |.|... | || | |.| |...||  |||...| .|.| ...  |. .  |. | ..|||||.||||......  |    ... | . . | 
tksyvlrelvlkdket.keerkilqlqylaWpdhgvPddsadflefverv..rklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivr

AIEEDRPYIIQTKDQYVFIHQTIL
 . . |  ..||..|| |. ..||
tmrdqramlvqtasqykfvCeail
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1-222 1.7e-62 206.3 In-house 64-282 (297) alignment 
Range on Protein: 1-222
Range on HMM: 64-282/297.0
DHSRVMLRGAGSG--CDYINATYIKGFDGtpkTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNElKCHQYWPSTDQpATYGVLTVSLKKKEEF
| |||.|.  ..    ||.|| ..||.      .|. | | ... .|||.||..|. |.||||. . |... || .||. .   .|.| ..| |.  .| 
dssRvkLaivnddpdsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgv.ttfGdvsvvllsvser

SDYTVRSLLLSKqGTLKEVRLIHQYQFTSWPHRGVPQ--QTAALLRFRKNIINRSPHVPKSgPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYV
. .  |.| ..| |  |  |...||||..||.. |..  ....|| . ... .   .. .. | ..||.|||||||..| || .. .||..| |||...|
eGfikrelevtk.gkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg.PllvhclaGvGrtgvlltidsvvaeakrekevdifglv

YAIEEDRPYIIQTKDQYVFIHQTILE
  . ..|||..|||.|| |.....||
kklrqerpylvqtkeqykfvyvavle
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 2-222 1.8e-62 206.4 In-house 39-253 (284) alignment 
Range on Protein: 2-222
Range on HMM: 39-253/284.0
HSRVMLRG-A-GSGCDYINATYIKGFDgTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTgliegnELKCHQYWPSTdQPATYGVLTVSLKKKEEFS
...| |.      . |||||..|.|.   .. |||.||||. . .|||.|.|. .|| ||.||      . || ||||      ...   |...  || .
knvvklerliGeefsdyinasfitGyq.rkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplk.ivikeerfkvkvdsveese

DYTVRSLLLSKQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHVPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVYAI
.|.||.. ||..|  |..| |.|. |  ||. |||.... |.|. |..   . .  .  . ..||||||||||...|.|..| . ||.| ||.||.|  .
eyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdl

EEDRPYIIQTKDQYVFIHQTILE
 ..|. ..|   || ||. ..||
rqqrntlvqdlvqykfiysalle
subfamily_PTPN12_pd Subfamily PTPN12 1-222 6e-62 204.1 In-house 53-275 (290) alignment 
Range on Protein: 1-222
Range on HMM: 53-275/290.0
DHSRVMLRGAG--SGCDYINATYIKGFDGtPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPST-DQPATYGVLTVSLKKKEE
|.|||.|.      | ||||| .||| .| ...||||||||    ||||.|.|. . ...||.  ..| .  ||..|||.. ... ..| ..|.|.... 
dksrvelskieeeegsdYinanfikgveg.kleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeeka

FS-DYTVRSLLLSKQgtlKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPhvPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKV---VDIY
.. |...|.| . .|   || | ..|...|.|| .|||...  ||.. ... ..     .. | ..||||||||||. ..|| . .. |..|.   .|..
vdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvf

NYVYAIEEDRPYIIQTKDQYVFIHQTILE
. |  . ..|. ..|||.||........|
dlvlelrkqraalvqtkeqyelvykavae
subfamily_Ptp69D_pd Subfamily Ptp69D 3-222 4e-61 201.8 In-house 63-284 (307) alignment 
Range on Protein: 3-222
Range on HMM: 63-284/307.0
SRVMLRGA--GSGCDYINATYIKGFDGTpKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTdQPATYGVLTVSLKKKEEFSD
 ||.|.        ||||| .|||.. . |..||||.|.|.  .|||.|... .  .||||. | | |. ||..|||   .   || . | | ..|. ||
tRvkLkkingkedsdYinasfikgykek.kkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsd

YTVRSLLLSKQG----TLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHVpkSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYV
|. |.| .||..     ... | . ||..|.|.   ||... .||.. ... .   .    .| ..||||||||.|||. .| .| | |. . |||.. |
yiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln..rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetv

YAIEEDRPYIIQTKDQYVFIHQTILE
  . ..|. ..|  .||||... .|.
kdLrsqRnllvqsleqYvflyralld
subfamily_PTPN9_pd Subfamily PTPN9 1-222 1e-60 200.3 In-house 55-288 (297) alignment 
Range on Protein: 1-222
Range on HMM: 55-288/297.0
DHSRVMLRGA--GSGCDYINATYIKGFDgTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWP-STDQPATYGVLTVSLKKKEE
|..||.|      .  ||||| .. |.   .|..||.||||.  ..|||.|||.... |||| | ..|   ||| |||| .... | .| |.||  . ||
detrvvlakvdedeasdyinanfvdGyk.qkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnvevee

FSDYTVRSLLLSKQGTlKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIIN-----------RSPHVPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKE
 .||.||.| ...  | .| | .  .||.|||  |||...|.|| ..... .           ..   |.  | ..|||||.|||| |  .|  | . .|
eedykvrvleiknvkt.eesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrlee

KKVVDIYNYVYAIEEDRPYIIQTKDQYVFIHQTILE
. .||. . |  . . | . ||| .||.| ....||
vgtvdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1-221 1.1e-60 200.0 In-house 59-280 (290) alignment 
Range on Protein: 1-221
Range on HMM: 59-280/290.0
DHSRVMLRGAGSGCD----YINATYIKGFDGTpKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQPAtYGVLTVSLKKKE
|  |..||  ..  |    ||||.||||.    | |||.|||...   |||...||||...|||||  || .. ||.||||..|. | ||  .. | . |
ddnritLrpisghkDCtneyinAcyikgykek.kqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllnee

EFSDYTVRSLLLSKQGTLKEVRLIHQYQFTSWPHRG-VPQQTAALLRFRKNIinRSPHVPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNY
....|. | | . .. . .. . ..|||.|.|.. | |..... || ... .  .  . .  .. ..|||..|||...|....  . ..| . |.|... 
tlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemy..ktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqv

VYAIEEDRPYIIQTKDQYVFIHQTIL
..     .|  .||..|| .|.| .|
lksqRiqkpgsvqtvqqyqgifqivl
subfamily_PTPN23_pd Subfamily PTPN23 1-221 1e-57 190.2 In-house 56-277 (288) alignment 
Range on Protein: 1-221
Range on HMM: 56-277/288.0
DHSRVMLRgaGSGCDYINATYIKGFDGTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPS-TDQPATYGVLTVSLKKKEEFS
||.||.||  ||  |||||...|.   .  ..||.|.||.|.  |||.||...| ||||||.   | .. |...|||. .... ..| |.|.||...| .
DhnRvklr..gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvrete

DYTVRSLLLSKQGTLKeVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIIN--RSPHVPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKE-KKVVDIYNYV
 .  | | |. ... . |. .   |.||||. |||.    ||.| ... .  .. . .   | ..||||||||||.| .. | .|. .. . ..|| . |
thvervlkletldada.vksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvv

YAIEEDRPYIIQTKDQYVFIHQTIL
  . |.| . .|.|.|. |  . .|
srlreqRrfmvqekeqlkfsyeavl
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1-221 1e-57 190.3 In-house 60-275 (287) alignment 
Range on Protein: 1-221
Range on HMM: 60-275/287.0
DHSRVMLRgaGSGCDYINATYIKGFDGTpKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQpATYGVLTVSLKKKEEFSD
|  ||.|.  |   |||||..|.|.    | .|.|..|. .   .||....... ..||||. . | .| .|.||||...   ..|  ...| ..|  ..
dnyrvllk..gehpdyinavfidgykek.kafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnag

YTVRSLLLSKQGTLKEVRLIHQYQFTSWPHRG-VPQQTAALLRFRKNIinRSPHVPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVYAI
|..| | . ...  .. . ..|||.|.|. .| |... . || . . .  .. . .  .. ..|||..|||...|. ..  ....|.  |.|... .   
yierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemy..ktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksq

EEDRPYIIQTKDQYVFIHQTIL
   .|  .|| .|| || . .|
riqkpgsvqtveqykfindivl
subfamily_PTPN13_pd Subfamily PTPN13 1-222 2.3e-57 189.4 In-house 50-267 (273) alignment 
Range on Protein: 1-222
Range on HMM: 50-267/273.0
DHSRVMLRGAGSgcdYINATYIKGFDGT-PKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTD-QPAT-YGVLTVSLKKKEE
|..|| | . |.   ||||..||   |    .|||.||||  ...|||||||. |..||.|.|   |....|||.|||..  .. . .. |.|.| | ..
detrvklgdegg...yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqk

FSDYTVRSLLLSKQGTlKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIinRSPHVpKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVY
 ....||.| .... . .|.| . . .|..||  |||...| ||.| ...  |. .  ..|| ..|||||.||.|....||..|   . .| .|. . | 
ldgfvvralavkdses.gesrevahlnfvkwPdhgvPssaaellqfvaev..rrlqt.dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivr

AIEEDRPYIIQTKDQYVFIHQTILE
 . | |  ..||||||.|....|||
klreqrqgvvqtkdqyifvykaile
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 3-222 2.6e-57 188.9 In-house 48-264 (283) alignment 
Range on Protein: 3-222
Range on HMM: 48-264/283.0
SRVMLRGAGSgcDYINATYIK--GFDGTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQpATYGVLTVSLKKKEEFSD
 || |.      |||||..|     .   | ||.||.||.    |||.||..|| . ||||| | |... || ||||.      || .||.|.|      
wrvelksesr..dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGs.edyGeftvtlrkettsns

YTVRSLLLSKQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHvpKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVYAIE
.... ||| .... |.  |.  ||.  | . |      .|..| | | ..  .  | || ..|||.|.|||..|. . | . .|. . |||... |  . 
fiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqtes..kkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimr

EDRPYIIQTKDQYVFIHQTILE
|.|. ..||.||| ..|. .||
eqrmmavqtldqyklvhelvle
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 12-221 4.7e-57 188.0 In-house 46-261 (270) alignment 
Range on Protein: 12-221
Range on HMM: 46-261/270.0
SGCDYINATYIKGFDGTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQP---ATYGVLTVSLKKKEEFSDYTVRSLLL
|   |||| |..|||| .|.||||.|||...  .||.|.|.|| . |||.||| | .  || .|||.  .     ..| ..|   ..|  . | .. | |
sataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrl

SKQGTlkEVRLIHqYQFTSWPHRGVPQQTA------ALLRFRKNIINRSPHVPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVYAIEED
 ..|.  | ||.| .....|| .|||...        ||.  ... . . .  |..|...||||||||||.....| ..|  .|.| ||. . . .. .|
eekge..errlvH.fwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkd

RPYIIQTKDQYVFIHQTIL
|. ..|. .|| |......
Rmalvqhpeqyeflykavv
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1-222 4.8e-57 188.5 In-house 61-286 (325) alignment 
Range on Protein: 1-222
Range on HMM: 61-286/325.0
DHSRVMLRGAG--SGCDYINATYIKGFDGTpKTYIAAQGPLESSCDDFWQMV--WQekCSVIVMLTGLiEGNELKCHQYWPST-DQPATYGVLTVSLKKK
|.|||.|   .  . .|||||.|.. . .  ....||| || .. .|.|..|  |.  |||.|.|  | .... .| .|||    .  |.| | |.|.  
dksrvvletkkddpssdyinasylrddkkk.dvflaaqaPltatindlWrlvldWr..csvvvvlnel.dlgkdrcavywpkemgksktfGglevklrti

EEFSDYTVRSLLLsKQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHVPK----SGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVD
||.|||  | | . ||    | | ..|.|. ||.  ||... |.|. . . . . |  |      |.| ..||||||||||.|. . ..| .  |.  ||
eeisdyvhrvldv.kqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvd

IYNYVYAIEEDRPYIIQTKDQYVFIHQTILE
|...|  . .||| ...| |||..|.... |
ifgfvkklrkdrpsmvetvdqyiliyealve
subfamily_PTPN1_pd Subfamily PTPN1 1-222 9e-56 183.7 In-house 45-269 (290) alignment 
Range on Protein: 1-222
Range on HMM: 45-269/290.0
DHSRVMLRGAGSgcDYINATYIKgFDGTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQ--PATYG--VLTVSLKKKE
||||..|. |    |||||. .. ..   . || .|||| . .| ||||||..|.  .|||  ..| ...||.||||. ..    ..    |.| | ..|
dhsrikleradn..dyinaslve.leeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvklisee

EFSDYTVRSLLLSKQGTlKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHVPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKV---VDIY
. | |||| | | .. | .| | | .. .|.||  |||.  ||.|.|  .. .    ... || .||||||.||.| | ..|..| . ..|.    ||| 
rksyytvrllelenlkt.qetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdik

NYVYAIEEDRPYIIQTKDQYVFIHQTILE
. . .. . |  .|||.||  | ...|||
kvllelrkyrlGliqtadqlrfsylaile
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 4-222 1.6e-52 173.2 In-house 61-234 (392) alignment 
Range on Protein: 4-222
Range on HMM: 61-234/392.0
RVML--RGAGSGCDYINATYIKGFDGtPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNelkchqywpstdqpatygvltvslkkkeefsdy
||.|      .  ||.||.||..||   |.|||.|||  .| ||||.||.||. . |.|.| | ||.                                 
rvkleviddipdsdylnasyipsfdn.ekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.................................

tvrslllskqgTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIinRSPHVPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVYAIEE
             ...| . |..|| || ..||..|..||.| |..  .. .   . | ||||||||||||. . ||... .||. ..||..|.|  | .
...........kgddartvaqfhftewPdkdvpkhtssllkfikev..kadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirr

DRPYIIQTKDQYVFIHQTILE
 |||..|||.|| ||. ..||
krpymvqtkeqyafiygavle
subfamily_PTPRN_pd Subfamily PTPRN 1-220 8.8e-52 170.6 In-house 69-288 (297) alignment 
Range on Protein: 1-220
Range on HMM: 69-288/297.0
DHSRVMLRGA--GSGCDYINATYIKGFDGTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQpATYGVLTVSLKKKEEF
||||| |.     .  |||||. |   |    .|||.|||| |.  |||||||.. . |||.|| | | .  .|..||| . . ..|..  | |  .  .
dhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGs.evyhiyevhlvsehiw

S-DYTVRSLLLSKQGTlKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNiINRSPHVpKSGPWIIHCSAGVGRTGIFLVIDAMLR-QAKEKKVVDIYNYV
. || |||. |    | .| | . |. | |||..||| .. .|| ||.  .|.|    .| | ..|||.|.||||....|| .|   .|  | .||   .
cddylvrsfylknlqt.setrtvtqfhflswpeegvPasaksllefrrk.vnksyrG.rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatl

YAIEEDRPYIIQTKDQYVFIHQTI
  . ..|| ...||||. |. ...
ehlrdqrpglvktkdqfefaltav
0051429 (Phosphotyrosine protein) phosphatases II 15-221 1.8e-51 170.6 In-house 5-222 (272) alignment 
Range on Protein: 15-221
Range on HMM: 5-222/272.0
DYINATYIKGFdGT---PKTYIAAQGPLESSCDDFWQMvWQEKCSVIVMLTGLIEGNELKCHQYWP-----------STDQPATYGVLTVSLKKKEEFSD
.|||| ...|. |    |.......|||. ...|||.. .......||.|... | . |||..|||           ..... .|| |.| | ..| ..|
gyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

YTVRSLLLSKQGTLKEVRLIHQYQFTSWPHRGVPQQTaaLLRFRKNIINrsphvpkSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVD--------I
|..| |||... . .|.| ......|.|| .||||..  ||.. . . .       .|| ..|||||..|||.. ... .|..  .  .||        .
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

YNYVYAIEEDRPYIIQTKDQYVFIHQTIL
...|  . . ||...|| .||.|... .|
eeaveelraqrpgavqteeqylflyeall
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1-222 4e-51 168.8 In-house 61-277 (439) alignment 
Range on Protein: 1-222
Range on HMM: 61-277/439.0
DHSRVMLRG--AGSGCDYINATYIKGFDgTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNElkchqYWPSTDQpATYGVLTVSLKKKEEF
||.||.|.         |||| ||||.  ..| |||.||| . ..||||..|...|.. ||||| |.|        |||| .. . || ..|   .. |.
dhtrvtlqeipgvphshyinanyikGyy.ddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdae.vcygdiavrvdrniel

SDYTVRSL-LLSKQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNiINRSPHVPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVY
 .|..| . .. .. | .  | . |.....||.. || |.. .| | .  || .    . || ..||||||||||  . .|  | | | .. |||   | 
pnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflra.insandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivk

AIEEDRPYIIQTKDQYVFIHQTILE
 . ..|  ..|.  |||||....||
vlrkqrkqmvqalcqyvfiynavle
subfamily_CG7180_pd Subfamily CG7180 1-222 8.8e-51 167.3 In-house 55-288 (296) alignment 
Range on Protein: 1-222
Range on HMM: 55-288/296.0
DHSRVMLRGA--GSGCDYINATYIKGFDgTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNElKCHQYWPSTDqPATYGVLTVSLKKKEEF
|. ||.|.     .  |||||.|. .|   .| ||  ..| ... |.||..|..|..| .|.||   . .. ....||| .   . || . | . .....
DynRvvLekldGeeksdYinavyvdsfl.kkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks.keqygeifveiveekqy

SDYTVRSLLLSKQ---------GTLKEVRLIHQYQFTSWPH-RGVPQQTAALLRFRKNI---INRSPHVPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAK
.. . | . | |.         .   |.|.....|.| |.    ||  |.||. .|. .   ... .. |. || ....| |..|.|..| ||| | ...
anlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelve

EKKVVDIYNYVYAIEEDRPYIIQTKDQYVFIHQTILE
... ||....|  . ..|| .......| .| ...||
keeevdvFeavktlrrsRpqLvenveeYkyiYdvlle
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 15-220 3.5e-49 162.1 In-house 71-289 (301) alignment 
Range on Protein: 15-220
Range on HMM: 71-289/301.0
DYINATYIKGFDGTpKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTD-QPATYGVLTVSLKKKEEFSDYTVRSLLLSKQG-
.||||.||.|.  . | .||||||...   |||...|||| . |||.|.| || . ||.||||... .  ..| .|| |...  . |...|.| .  |  
eyinasyidgysek.kkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdg

-------------TLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHVpKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVYAI
             . |. . . |.| |.||. || .. .  |.   ..| |   .   || ..|||..|.|.|..  ..  | |.|   |||... . |.
snngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqki.gggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkav

EEDRPYIIQTKDQYVFIHQTI
   .|  ..| .||..|.. |
rrskpgaVtTLeqytsiydvi
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1-220 4.1e-48 158.6 In-house 51-273 (287) alignment 
Range on Protein: 1-220
Range on HMM: 51-273/287.0
DHSRVMLRGAG-SGCDYINATYIKGFDGtPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQPATYGVLTVSL-KKKEEF
|..||.|   |  | ||||| |. ..    ...||||||. ..  |||..|.... ......|  .|   |||..|||  ..|   |  .| | ...   
ddtrvllsaegelGsdyinanyvasytd.deafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGGysvvlldydike

SDYTVRSLLLSKQGTlKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNI---INRSPHVPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNY
 .|.||.| | .  | .| |...|... ||| ....  . .|.||  ..   |. .    . || ..|...|.||.||.| . ..... ..   ||. . 
Peygvralrlidlet.rearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaav

VYAIEEDRPYIIQTKDQYVFIHQTI
|  . | |  ..|.  |. .. ...
virlreyraalvqavvqlrllyeal
subfamily_PTPN14_pd Subfamily PTPN14 2-221 8.7e-48 157.8 In-house 63-293 (300) alignment 
Range on Protein: 2-221
Range on HMM: 63-293/300.0
HSRVMLRGAG-SGCDYINATYIKGFD-GTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPST---DQPATYGVLTVSLKKKE
..|| |  .  .  .||||. ||    |. ..||.||||||  . |||||||... ..|||||  .|.   |...|.|..    . ...|   |. | .|
dnrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfse

EFSDYTVRSLLLSKQGTlKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPH-------VPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKV
. . .. ..| |    . || | ..  |.| || .|||.     | . ...     .         .. | ..||||||||||. .. | ..   .  ..
dsdsvittglklkhlps.keertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehnee

VDIYNYVYAIEEDRPYIIQTKDQYVFIHQTIL
.|| . .  . | | ...||  || |......
idikkvlarLreqrmllvqtlaqYkfvYkvli
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1-221 6.5e-42 138.2 In-house 69-280 (290) alignment 
Range on Protein: 1-221
Range on HMM: 69-280/290.0
DHSRVMLRGAGSGcDYINATYIKGFDgtpKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTD-QPATYGVLTVSLKKKEEFS
| .||.|.  . | ||. | |.|| .    ..| .||.|...  |.|.|| ||| ..||||  |||    ||.||.| .. .  |.| .||   ....  
dktrvilkdGydG.dyvhanyvkGlk...amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkd

DYTV-RSLLLSKQGTLKEVRLIHqYQFTSWPHRGVPQQTAALLRFRKNIINrsphvpKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVYA
. .. . | . .. . || .| | ..  ||| . |.. | ||||  . . .       ||| ..|||||.|||| |  |.. |.   . | .|. . | |
aniikktlsvrdkdsGkehklkh.lkikswpdksvalstlallrtlrilrk......asGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvra

IEEDRPYIIQTKDQYVFIHQTIL
. . |   .|   ||. . . .|
lrnsrlnsvqvdiqylalveill
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1-222 5.6e-41 135.5 In-house 54-275 (307) alignment 
Range on Protein: 1-222
Range on HMM: 54-275/307.0
DHSRVMLRGAGSGCDYINATYIkGFDGTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTD-QPATYGVL--TVS---LKK
|..|....  |   ||| | |. |    || .|.||||||..  .|| |. |||   ..||  .||  ..||.||||  . |  ..|    |.|   |  
dkgrivvkfdglasdyihanyl.giaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlga

KEEFSDYTVRSLLLSKQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLrfrkNIINRSPHvpKSGPWIIHCSAGVGRTGIFLVI----DAMLrqaKEKKVV
|.   |  .  .   |    .. | |...|.. || |||||   . .    |...      .  | ..||||||||.|  . |    | |.   . .   
kklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltai....nlleavry..dtnpvvvhcsaGvGrsGtivaislvqdkmi...aGinck

DIYNYVYAIEEDRPYIIQTKDQYVFIHQTILE
|. . |  . ..|.| |||. ||...|. .||
dmkklveelrsqrhyaiqteaqylylhrvlle
0036282 (Phosphotyrosine protein) phosphatases II 14-218 5.9e-41 135.4 In-house 2-164 (174) alignment 
Range on Protein: 14-218
Range on HMM: 2-164/174.0
CDYINATYIKGFDGTPkTYIAAQGPLEsscddFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPStdqpatygvltvslkkkeefsdytvrslllskqGT
 |||||......  ||  .|| ||||.     ||.|.........|||. ..| .  ||..|||.                                   
sdyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lr

LKEVRLIHQYQFTSWPHRGVPQQTAaLLRFRKNIINRSPHvPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKeKKVVDIYNYVYAIEEDRPYIIQTKDQY
  ..||..||... || .|||  .  ||.| | . .   . ...|| ..||||||||||.. ... |||. .  ..||....|...   ||...|| .||
edlerlgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQy

VFIHQ
 |...
rflyy
0041856 (Phosphotyrosine protein) phosphatases II 8-222 1.1e-39 131.2 In-house 13-169 (182) alignment 
Range on Protein: 8-222
Range on HMM: 13-169/182.0
RGAGSGCDYINATYIKGFDGTPKtYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTgliegnelkCHQYWPstdqpatygvltvslkkkE-Efsdytvrsl
   . ..||||| .. |   . . .||.|||| |.. ||..|........||.||         ...|||                  | .         
ydhsrdldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywp..................ell.........

llskqgtlkeVRLIHQYQFTSWPHRGVPQqTAALLRFRKNIINrsphvpKSGPWIIHCSAGVGRTGIFLVIDAMLRQakekKvVDIYNYVYAIEEDRPYI
           ||..||....||  |||  .  ||.| . ...      ..|| ..|||||||||| . ... |...    . |.... |  . . || .
..........erlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpgm

IQTKDQYVFIHQTILE
..| .||.|... .||
vitpnqyfflqlalle
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1-220 1.3e-39 130.9 In-house 46-255 (267) alignment 
Range on Protein: 1-220
Range on HMM: 46-255/267.0
DHSRVMLRGAGSgcDYINATYIKGFDgTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNelkCHQYWPST-DQPATYGVLTVSLKKKEEFS
|..||.||      .||||.|..|.  | ...|. |.||. .  ||.... ..|..|||.||   ..|    ...||    |   |  |||    ..|  
ddtrvilrtkee..eyinasyvegyk.tknafivtqdplkntitdfltvihdqkvpvivlltkvftdn...irlfwPPkmgqakkyqdltvehslekeen

DYTVRSLLLS-KQGTLKEVRLihqYQFTSWPhrgVPQQTAALLRFRKNIINRSPHVPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVYA
|| . .| |  |. . ..| |   | .  |    .  .    |.    |. .      . | ...||.||||.| |||||..|..||.  |.||....  
dyqiitlelkfknesahnvtl...yyykkwn...intnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrk

IEEDRPYIIQTKDQYVFIHQTI
| . |. ...||..|..||...
irsqriglvdtkeryiyihell
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1-221 1.2e-38 127.6 In-house 61-284 (305) alignment 
Range on Protein: 1-221
Range on HMM: 61-284/305.0
DHSRVMLRGAGsGCDYINATYIKGfDGTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQPATY---G--VLTVSLK--
|. || |.|.    .|| | |.      || .| .| ||| .| ||| | .|.|   | ||  |.|    ||..|..| |..      .   ..| ..  
dnnrvklegpw.pheyihanyvst.ptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfess

KKEEF---SDYTVRSLLLSKQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIinRsphvPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVV
.. .|   .. .|.   |  .|. ...| . .| .  || ||||    |.| . ..   |    |  || ..|||||.||||  .... .| |  . ...
vtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelleka..r....pskgpivvhcsagigrtgsvvmleyildqllagqii

D-IYNYVYAIEEDRPYIIQTKDQYVFIHQTIL
.     .  | |.|   ||| .||.|.|| ||
edtdkilqkireqrnnsiqtdaqylfvhqvil
0046846 (Phosphotyrosine protein) phosphatases II 5-221 2.9e-38 126.7 In-house 3-170 (176) alignment 
Range on Protein: 5-221
Range on HMM: 3-170/176.0
VMLRGAGSGCDYINATYIKGFdgtpkTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPStdqPA---Tygvltvslkkkeefsdy
..|.| . ..||||| .| |       .|| ||||.... ||..|.........|.|| ..| . |||..|||                           
lrllgldldldyinanlilgs.....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe...leklgi.................

tvrslllskqgtlkevrlihQYQFTSWPHRGVPQQtAALLRFRKNIINrspHVPKSGPWIIHCSAGVGRTGIFLVIDAMLRqakeKKVVDIYNYVYAIEE
                    ||... ||  |||.  ..||.. . | .   .. . || ..|||||.|||| ..... . .    .| ..... .. . |
....................qylhlpwpDhgvpdl.elllellefire...alkeggpvlVHCsaGigRtgtlvaayllel....ekglsveealalvre

DRP-YIIQTKDQYVFIHQTIL
 || ...|| .|| |... .|
qRplgavqtpeQyrflyefel
0043147 (Phosphotyrosine protein) phosphatases II 12-218 1.6e-37 124.2 In-house 3-155 (172) alignment 
Range on Protein: 12-218
Range on HMM: 3-155/172.0
SGCDYINATYIKGFDGTPKtYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLiegnelkchqywpstdqpatygvltvslkkkeefsdytvrslllsKQ
.|.||||| |...   ... .|| |||| . ..|||.|........||.||.|                                               
egsdyinasyldlyyipdr.fiatqgplrntladfwrmlkelgithivnltel.............................................ly

GTLKEVRLIHQYQFTSWPHRGVPqQTAALLRFRKNIINRSpHVPKSGPWIIHCSAGVGRTGIFLVIDAMLrqakekKVVDIYNYVYAIEEDRPYIIQTKD
 . ...||. ||....||  |||  .. ||.| . | ..  .. ..|| ..|||||||||| . ... ||      . ..... |  . | ||...|...
dpellerlgiqylylpwpDhgvp.llellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnps

QYVFIHQ
|| |...
qyrflyy
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 10-221 2.3e-36 120.0 In-house 76-286 (305) alignment 
Range on Protein: 10-221
Range on HMM: 76-286/305.0
AGSGCDYINATYIKGFDGTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQP---ATYG--VLTVSLKKK-EEFSDYTV
  | .||| | |.       | .|.|||||. . |.|| || |.|   ||||   .|   ||| |||| .         |  |  ||  |  |  ..  .
kpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqi

RSLLLSKQGTLKevRLIHQYQFTSWPHRGVPQQTAALLRFRKNIinRSPHVpksgPWIIHCSAGVGRTGIFLVIDAMLRQ-AKEKKVVDIYNYVYAIEED
  | |.  |  |    . . |.| || ||||    . | .   |  |  .|    | ..|||||.||||  . |. .| . |..|..  . . | |. ..
tllnltysgdqk..msvrhlqwtewpdrgvppckltslellsai..rgskv....pivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdq

RPYIIQTKDQYVFIHQTIL
| . ||.  ||.|||. .|
rafsiqndvqylfihrvml
0049260 (Phosphotyrosine protein) phosphatases II 28-218 8.7e-36 118.3 In-house 7-144 (152) alignment 
Range on Protein: 28-218
Range on HMM: 7-144/152.0
TPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWpstdqpatygvltvslkkkeefsdytvrslllskqgtlkevrlihQYQFTS
 |. .||.|||.. ...|||.|... ....||||| | | ..|||.||.                                             ||... 
mpfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................qylhlp

WPHRGVPQQTAALLRFRKNIINRspHVPKSGPWIIHCSAGVGRTGIFLVIDAMLrqakekKVVDIYNYVYAIEEDRPYIIQTKDQYVFIHQ
||  |||. .  || . . |  .     |.|| ..|||||||||| . ... ||      . |.....|  . | ||.......|. |...
wpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
0051082 (Phosphotyrosine protein) phosphatases II 15-221 1.8e-34 113.9 In-house 4-150 (151) alignment 
Range on Protein: 15-221
Range on HMM: 4-150/151.0
DYINATYIKGFdgtpktYIAAQGPLEsscdDFWQMVWQEKCSVIVMLTGLIEGNelKCHQYWPSTDqpatygvltvslkkkeefsdytvrslllskqgtl
||||..|. |.      ... .|||.    ||...........||.|... | .  .|..|.|...                                  
dyinfsyvtgg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

kevRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINrsphvPKSGPWIIHCSAGVGRTGIFLVIDAMLRQakekkvVDIYNYVYAIEEDRPYIIQTKDQYV
   . ........||  |.|. ..|.|.| . ...     .|.|| ..|||||.||||.. ... ||..      |...  .  . . ||...|...|..
...ievlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqfl

FIHQTIL
|... .|
fqlfall
0049772 (Phosphotyrosine protein) phosphatases II 10-220 3.9e-33 110.9 In-house 68-276 (314) alignment 
Range on Protein: 10-220
Range on HMM: 68-276/314.0
AGSGCDYINATYIKGFdgtpKTYIAAQGPLESSCDDF----------WQMV--WQEKCSVIVM---------------------LTGLIEGNelkchqyw
 .||.||||| |..||    ...||.|||||  ..||          |.||  .. .. .|||                     |..| ...        
pvsgsdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng........

pS----TDQPATYgvltvslkkkeefS------DYtvrslllskqgtlkeVRLIHQYQFTSWPHRGVPqQTAALLRFRKNIINRsphvPKSGPWIIHCSA
 .     |..                .      ..                ||. .|  . .|  ..|  .. ...| . | .     .| || ..||.|
.neptaadlellk.............eelydpelf...............erlgikylripvpDgsap.lledfdeflefieea....dkggpvlvHCka

GVGRTGIFLVIDAMLRQAKEkKVVDIYNYVYAIeedRP-----YIIQTKDQYVFIHQTI
|.|||| |.|.. .... .   . .....| ..   ||       |.. .||.||.. .
GkgRtgtfvvaaylmkllgv.sleealedvrlk...Rpinpnpgfieqleqyefileal
subfamily_ptpA1_pd Subfamily ptpA1 2-183 1e-32 108.5 In-house 61-255 (418) alignment 
Range on Protein: 2-183
Range on HMM: 61-255/418.0
HSRVMLRGA--GSGCDYINATYIKGfdGTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPS---TDQPATYGV-----LTVS
|.|| |.      | ||||| || |    || .|..||||  .  |||.|||...| .||||.   |   .|| .|||     .| . ||       | |
htrvqlkkiqdkegsdyinanyidg..aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtys

LKKKEEFSDYTVRSLLLSKQGTL-KEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHV----PKSGPWIIHCSAGVGRTGIFLVIDAMLRQ
..  |   |     .    . |.  | | | |||.  || . .|..|  . .. ..| ||  ..     .  | |.|||||||||| |     |...
velveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkk
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 17-215 5.9e-31 102.3 In-house 78-272 (301) alignment 
Range on Protein: 17-215
Range on HMM: 78-272/301.0
INATYIKGFdGTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPST-DQPATYGVLTVSLKKKEEFSDY-TV-RSLLLSKQGT
| | .|.   | |. .||.||||.....||| |. | .   ||||.  .| .| ||..| |..  .    |  .. .|.||   .  .. |.| .     
ihanwipts.GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstg

LKEVRLIHQYQFTSWPHRGVPQQTAALLRFrKNIINRSPHvpksgPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVYAIEEDRPYIIQTKDQY
  . | .  ||...|..||||.  | |  .  ... .| .     | ..|||||.||.  |.  . . |. . .. ... . .  . |.|   .||. | 
kfatrtvthyqysewtdrgvPkshaelfdl.melvkksek.....PivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsql

VF
 .
yw
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1-149 8.6e-31 101.9 In-house 46-195 (297) alignment 
Range on Protein: 1-149
Range on HMM: 46-195/297.0
DHSRVMLRGAGSGCDYINATYIKGFD-GTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQPAT-YGVLTVS--LKKKE
| .|| |... .. ||||| |.   |  ..  || |||||... ||||..|...   ||||.. | |.   ||  ||||..|     | . |    .  .
ddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsd

EFSDYTVRSLLLSKQgtlKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIIN
||    .  | |  .   .| | ..  || |||  ||| .   | ||. ....
efdrviltelqliyr...sesrvvrhvqflswpdhGvpsdledlvrfqaqvcs
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 11-221 2.8e-30 99.9 In-house 63-266 (281) alignment 
Range on Protein: 11-221
Range on HMM: 63-266/281.0
GSGCDYINATYIKGFdGTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQP-ATYGVLTVSLKKKEEFSDYTVRSLLLS
    ||| | ||.      . || .||| . .  |||.|.|||. . ||||  ..| |  || .|.|   .    .  |.|| .            | ||
knstdyihanyirsp.flkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnls

KQGtlkEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSphvpksGPWIIHCSAGVGRTGIFLVIDAMLRQAKEK-KVVDIYNYVYAIE-EDRPYII
 .|   | ||| .. .  ||   ||. .  .|.  ..|  ||       | .|||||||||.| .. ..  |.  . .  . || . |  .    |   .
yeg...etrlithwlwkewpdwqvpessevmlkilrkirars......tppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasv

QTKDQYVFIHQTIL
|| .||..| . .|
qtlqqymliwkvll
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 30-218 8.9e-30 98.3 In-house 5-198 (199) alignment 
Range on Protein: 30-218
Range on HMM: 5-198/199.0
KTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQP-ATYGVLTVSLKKKEEFSDYTVRSLLLSKQGTLK-EVRLIHQYQFTS
. |||.| ||  .  |||||||.     |||.      .|     |||.|.   . || |.|. |     .|||. .|.|... |     | | .|||||
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPHRGVPQqTAALLRFRK--NIINRSPHVPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKK--VVDIYNYVYAIEEDRPYIIQTKDQYVFIHQ
|  .  |.  | .. |      . .     |  | |.||| | | ||.|. .|  .|  .| |  |||...    . . |  || . ..| ||.|
wkekttpn.valfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 30-218 9e-30 98.3 In-house 4-197 (198) alignment 
Range on Protein: 30-218
Range on HMM: 4-197/198.0
KTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQP-ATYGVLTVSLKKKEEFSDYTVRSLLLSKQGTLK-EVRLIHQYQFTS
. |||.| ||  .  |||||||.     |||.      .|     |||.|.   . || |.|. |     .|||. .|.|... |     | | .|||||
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPHRGVPQqTAALLRFRK--NIINRSPHVPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKK--VVDIYNYVYAIEEDRPYIIQTKDQYVFIHQ
|  .  |.  | .. |      . .     |  | |.||| | | ||.|. .|  .|  .| |  |||...    . . |  || . ..| ||.|
wkekttpn.valfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
0044763 (Phosphotyrosine protein) phosphatases II 13-218 1.5e-29 98.3 In-house 17-165 (178) alignment 
Range on Protein: 13-218
Range on HMM: 17-165/178.0
GCDYINATYIKGFdgtpkTYIAAQGPlesscDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQpatygvltvslkkkeefsdytvrslllskqg
..|||||..| ..      |.....|      |............||.||. .|.. |||..|||.                                  
rsdyinaseilpg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...............................

tlkevrliHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPhvPKSGPWIIHCSAGVGRTGIFLVIDAMLRQakekKVvDIYNYVYAIEEDRPyIIQTKDQ
         ||... .|  |||. .. .|.| . | .  .  .| || ..||||||||.| . ... |...    .. .... .  . | || |... .|
........iqylhipipDhgvpdllehflefvefieeald..ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgq

YVFIHQ
. ....
lrqLye
PTPc_DSPc_SM00012 120-222 2.1e-29 97.2 In-house 2-105 (105) alignment 
Range on Protein: 120-222
Range on HMM: 2-105/105.0
IHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHVPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEK-KVVDIYNYVYAIEEDRPYIIQTKDQYVFIHQ
...|..|.||. |||... ..|.. ... .   .  .|.| ..||||||||||.| ..| .|.| ... | |||...| .. . ||  .||..||.|...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

TILE
 .||
alle
subfamily_CG42327_pd Subfamily CG42327 14-141 5.5e-28 92.6 In-house 56-184 (319) alignment 
Range on Protein: 14-141
Range on HMM: 56-184/319.0
CDYINATYIKGFDGTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPST---DQPATYGVLTVSLKKKEEFSDYTVRSLLLsK
  |..|.|..|.| .|  ||||| .||.|  |||..||. .  ||| || | |    .| .|.|.    |.  .|| . |.||..|    | . .||| |
deyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlll.k

QGTLKEVRLIHQYQFtSWPHRGVPQQTAALL
.   .| | .  | .  |.. .|| . |||.
rvdkeesrelthywy.kwleaevPaeeaali
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 4-221 2e-27 90.9 In-house 51-267 (285) alignment 
Range on Protein: 4-221
Range on HMM: 51-267/285.0
RVMLRGagSGCDYINATYIKGFDGTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPST-DQPATYGVLTVSLKK-KEEF-SD
||.|.      ||| |....       |||..||||  .  |||.|..||| . ..||  |.||   ||  |.|    .   .|   ..| . |||  . 
rvvlkn..hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiag

YTVRSLLLS-KQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSphvPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVYAI
  . .| .   . .  |   . . |   || .  |...  .. . | . .     ||  |  .|||||||||  |. ||    .  |.  ... . |  .
tilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvn...pkekpicvhcsagvgrtatfvgidyatirimenpniemldivrem

EEDRPYIIQTKDQYVFIHQTIL
   |   .|.. |..|..  ..
ramrfqavqshmqflflyvvlm
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 2-219 2.1e-27 90.5 In-house 66-285 (310) alignment 
Range on Protein: 2-219
Range on HMM: 66-285/310.0
HSRVMLRGAGSG-CDYINATYIKGfDGTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQPATYGVLTVSL--KKKEEF
 ||| |.   |   ||| | |.|  .   .|.| .||||. .  |||.|..||..  |..|    |    ||  ||||     |||.. |.   .  |||
tsrvklkidksryedyihanyvkt.nylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseef

SDYTVR------SLLLSKQ-GTLKEVRlIHQYQFTSWPHRGVPQQTAALLRFRknIINRSPHvpksGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVD
    .        . . .|   |||.| .   ..  || ||||..    .  |  .. .  |    || ..|||||..|... . ..  . .... . ||
eicnlavtfvpdnvpvdeqpanlkelr.vslikwpnwpdrgvpdekchtvpqr..llaqvrh....gpcvvhcsagkdrlyvvvalklkidkldrglkvd

IYNYVYAIEEDRPYIIQTKDQYVFIHQT
. . .  .  .|   |||. ||..|.. 
aeevktellksraiciqtelqyliidrv
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1-222 2.8e-26 87.2 In-house 56-269 (288) alignment 
Range on Protein: 1-222
Range on HMM: 56-269/288.0
DHSRVMLRgagSGCDYINATYIKGFDGTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPST-DQPATYGVLTVSLKKKEEFS
| .|| |      .|.  |. .      ..  | || ||..  . .|.|. ..    ||||. |.|    |  .|.||   . | .| |    ||| .  
ditrvkls...ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradi

DYTVRSLLLSKQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIinRSPHVpksgPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVYAI
| .|.  ||  . . .|  .. .  .  |.. |||..  . ||. . .  .| .     | ..|.|||||||| . .|  .|.... .  . | . .   
dklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl..kslqk....PivvhssaGvGrtgtlililialeslrlddflgirsllakl

EEDRPYIIQTKDQYVFIHQTILE
 |.|   |||. ||...|. .||
reerfkaiqtemqylyvhrcvle
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 10-222 1.2e-25 84.9 In-house 63-274 (312) alignment 
Range on Protein: 10-222
Range on HMM: 63-274/312.0
AGSGCDYINATYIKGFdGTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTD------QPATYGVLTVSLKKKEE-FSDYT
||    || | ..|     |. ....|||||..|  |||..    .. |..|.|..|    || .|           .   |      ..         |
agdenfyihanfvkic.tkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkit

VRSLLLSKQGTLKEVRLIHqYQFTSWPHRGVPQQTAALLRFRKNIINrsphvpKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVYAIEED
 | | .  . | .| .| | ||..|||  |.|.   . ||.   . .         | | |||||||||| . .|..|.   .  .  .. .    .  |
hrvlkvvvkatgqesklnh.yqwaswpdhgmpdscdtalrllsavkk......dkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkd

RPYIIQTKDQYVFIHQTILE
|   ...  |||.  ...||
rarsvrvfpqyvyalrcvle
subfamily_egg_pd Subfamily egg 9-221 2.5e-25 83.8 In-house 64-267 (307) alignment 
Range on Protein: 9-221
Range on HMM: 64-267/307.0
GAGSGcDYINATYIKGfDGTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNelKCHQYWPST-DQPATY--GVLTVSLKKKEEFSDYTVRS
|  .. |.| | ..|| .    ..| || ||  . ||||.||.||..  |||||   | .  .|. ||| . .... .  | | .   | .. .|   | 
Gqyld.dfihanrvkG.kpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkese..rceyywpkaesdslvtvpGslrienlkvdskadplfrv

LLLSKQGTLKEVRLIHQYQFtSWPHRGVPQQTAALLRFRKNIinrsphvpkSGPWIIHCSAGVGRTGIFLVIDA----MLRQAKEKKVvdIYNYVYAIEE
  |   |. .| | .  .|   . . .       .||  .|.         | | ....  || ... .. |.     .||    | .  . . |  .  
tklklvGgddeerflehwqg.dvnnssdvysplrvlrklrnl.........skpvvvqdilGvskaatlvaieiallsllrGpitksl..vlravvflrl

DRPYIIQTKDQYVFIHQTIL
 |.. ...  .|.|... .|
rrrlsvesvllylfvyrlvl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 116-222 1.4e-24 81.2 In-house 87-192 (440) alignment 
Range on Protein: 116-222
Range on HMM: 87-192/440.0
EVRLIHQYQFTSWPHRGVPQQTAALLRFRKNiINRSPHVPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVYAIEEDRPYIIQTKDQYVF
| | ..||.. .|| .|||. .. .|.. .. .| | .   .|| ..|||||.||||. ...|..||.||    .||.... .. ..|| ..|| .||.|
esrtlkqyhyqgwpdkgvpkfagpvlkmiqd.vnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf

IHQTILE
.|...||
vheavle
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 11-220 3.4e-22 73.2 In-house 72-281 (302) alignment 
Range on Protein: 11-220
Range on HMM: 72-281/302.0
GSGCDYINATYIKGFDGTpKTYIAAQGPLESSC---DDFWQMVWQEKCSVIVMLTGLIEGNElKCHQYWP-STDQPATYGVLTVSLKKKEEFSDYTVRSL
..  .|.||. ..  . | .. | || |  .|    ..||.||.|||.  .|.| |  | ..   ....|  ...  .|| . |  .| |. .. . |  
aepdsyvnaskvevPelt.rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeektryv

LLSKQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRspHVPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVYAIEEDRPYI
.        .  |.  | .| |..  ||.. |.| .  ... ..  ... . . .|    |.|| |.||.  . . . ...| . | . | .| ..|| .
iEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfak..kikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpra

IQTKDQYVFIHQTI
... .|||... ..
vdslkQyvslyial
0048179 (Phosphotyrosine protein) phosphatases II 101-218 7.2e-20 66.6 In-house 31-139 (144) alignment 
Range on Protein: 101-218
Range on HMM: 31-139/144.0
YTVRSLLLSkQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPhvpKSGPWIIHCSAGVGRTGIFLVIDAMLrqakEKKvVDIYNYVYAIE
.|| .|  .      . | ..||....|| .|||. .. ||.| . | .  .   ..|| ..|||||||||| . ... |.    ... ..... .. . 
ttvinltee.yepefleregiqylhlpwpDhgvpdllellleflefieeale...eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvr

EDRPYIIQTKDQYVFIHQ
. ||..... .|. |...
srrpgavpnpgqlrfLle
0048076 (Phosphotyrosine protein) phosphatases II 93-219 7.8e-20 66.5 In-house 20-138 (145) alignment 
Range on Protein: 93-219
Range on HMM: 20-138/145.0
KKKEEFSDYTVRSLLLSKQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINrspHVPKSGPWIIHCSAGVGRTGIFLVIDAMLRqakeKKvVDI
.. |.. |. .. .|     .  ..||. ||....|| .|||. .. ||.| . | .   .... || ..|||||||||| . ... ||.    .. |..
ldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefiee...alkeggpvlVHCsaGvgRtgtlvaaylmll....lg.vsl

YNYVYAIEEDRPYIIQTKDQYVFIHQT
.. .  . . ||..... .|. |... 
eealelvrsqrpgavpnpgqlrflyef
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 42-203 7.9e-20 66.0 In-house 40-197 (255) alignment 
Range on Protein: 42-203
Range on HMM: 40-197/255.0
SCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPS-TDQPATYGVLTVSLKKkeEFSDYTVRSL-LLSKQGTLKEVRLIHQYQFTSWPHRGVPQQTAA
. | |.|.. | | .|.|||. . | .  ||..|.|   |.   .  ..|.  |    .|  .| | ..|. |  |. . .. |... |. .  |...  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

LLRFRKniinrspHVPKSGPWIIHCSAGVGRTGIFLVIDA----MLRQAKEKKVVDIyNYVYAIEEDR
.|   |        | .| . ..|||.|.||.  | ...     |.|. .. . |.. .|.  .|| |
ilnilk.......vvrdsksvvvhCstGiGrsaafvlaelvyqkmirsldttetvel.dylslleelr
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 26-216 1.9e-19 64.2 In-house 84-280 (302) alignment 
Range on Protein: 26-216
Range on HMM: 84-280/302.0
DGTPKTYIAA---QGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTD----QPATYGVLTVSLKKK-EEFSD---YTVRSLLLSKQGTL
||| |    .     |  |... .| .. | . ...| |....|..| || .|.        .   | | |||.|.. |||.|   ... .. .  . . 
dGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkk

-KEVRLIHQYQFTSWPHRGVPQQTAALLrfrkNIINRSPHVPKSgpWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVYAIEEDRPYIIQTKDQY
 |  . ..  .|..||. | |... . |    .|..      |.   ..|||||||||| .. |   .   ..||| |. . |  . . |   .|...| 
kkvkktvdilafsawpdhGapkeaytal....dilkfcesykkn..vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqql

VFI
...
iyl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 10-80 8.1e-19 62.5 In-house 79-154 (350) alignment 
Range on Protein: 10-80
Range on HMM: 79-154/350.0
AGSGCDYINATYIKGF----DGTPKT-YIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTD
. |. ||||| |.|      .  |.  |||.|.|| |  |||.... . |  ||..|| ..| |  ||..||.  .
slstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqegs
subfamily_CG42327_pd Subfamily CG42327 145-220 9.7e-19 62.2 In-house 235-311 (319) alignment 
Range on Protein: 145-220
Range on HMM: 235-311/319.0
KNIINRSPHVPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEK-KVVDIYNYVYAIEEDRPYIIQTKDQYVFIHQTI
 || .|| .  . || ..||| ||||||. .  |  .|. .|  . ||| . |. . .||   ..||.|| ||....
gnissrsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvl
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 3-220 1.1e-18 62.5 In-house 33-255 (290) alignment 
Range on Protein: 3-220
Range on HMM: 33-255/290.0
SRVMLRGAGSG--CDYINATYIKGFDGTpkTYIAAQGPLESS-------CDDFWQMVWQEKCSVIVMLTGLIEGNEL----KCHQYWPS-TDQPATYGVL
.||.|.| |.    ||| | ...  .|     |. | |.|           .|| |. |||   .|||    | ..      | .| |   ..  ... |
trvvLkgygkrfnddyiHAnrvtcpngl..rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgl

TVSLKKKEEFSDYTVRSLLLsKQGTLKEVRLIHqYQFTSWPHRGVPQQTAALLRFRKNIINrsphvpKSGPWIIHCSAGVGRTGIFLVIDAMLRQA-KEK
||. |.||.  |  .| |.. | .  .|  . | ... .| .. |...|  ||   ... .      .  | |.||  |. |  ..  |.       . .
tvkCkskekeddvetRelvv.kfddeeeftvtH.sllkgWnklnvqedtktllsliqkvka......sktpvivHcvdGiSrsAalaaiilgyQkiaets

KVVDIYNYVYAIEEDRPYIIQTKDQYVFIHQTI
. | . . ..|. . |   |... .. |.   |
gsvkledvlkalrkqralaitsalelafvdagi
subfamily_eak_pd Subfamily eak 15-221 6.5e-18 59.2 In-house 79-302 (332) alignment 
Range on Protein: 15-221
Range on HMM: 79-302/332.0
DYINATyIKGFDGTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTD-QPATYGVLTVSLKKKEEFSDYTVRSLLLSKQgt
 ||||. .  |    . || .  . |.    ||||| ..|   ||.|   .| .  |  .|.|    .   .|.| |  |.  . . . .| | |||   
Gyinas.laefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrllelskG..

lKEVRLIHQYQFTSWPHRGVPQQT--AALLR-----------FRKN-----IINRSPHVPKSGPWIIHCSAGVGRTGIFLVIDAMLRQ--AKEKKVVDIY
  |   .. |..  |    .|.     || .             |.     ....  | | |   || .. |  |.|.|.||| ..|   .| | .  . 
.nethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfapiiqsarGsaraGvfvvidllirlidnkkknlysve

NYVYAIEEDRPYIIQTKDQYVFIHQTIL
...  . . | . . .. |. ||.. .|
dlilkvkskrihsvlvalqhsfiyeivl
subfamily_hpo-7_pd Subfamily hpo-7 42-203 3.2e-16 54.0 In-house 46-203 (263) alignment 
Range on Protein: 42-203
Range on HMM: 46-203/263.0
SCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPS-TDQPATYGVLTVSLKKKEEfsDYTVRSL-LLSKQGTLKEVRLIHQYQFTSWPHRGVPQQTAA
  | |.|.. | | .|.|||.   | .  || .|.|   |.   .  ..|.  |  .  |  ...| |||  |  |... ...|... |...  |...  
tidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpelare

LLRFRKniinrspHVPKSGPWIIHCSAGVGRTGIFLVIDA----MLRQAKEKKVVDIyNYVYAIEEDR
 |.  |        . .| . ..|||.|.||.  | |..     |.|. .. . |.. .|.  .|| |
ilnilk.......varnskslvvhcstGiGrsaafsvaElvyqkmirsldttstvel.dylsLleelr
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1-220 1.2e-15 51.9 In-house 60-275 (303) alignment 
Range on Protein: 1-220
Range on HMM: 60-275/303.0
DHSRVMLrgagSGCDYINATYIKgFDgTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQPATYG--VLTVSLKKKEEF
|||.| |    |   || |.|.. .| . |  | .| ||  .. |||||. ..|  ....|    | ..|  .  .|  ..   .   .. |   |. |.
dhskvkl....sdssyihasyle.ld.sskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersirvgefkrvel

SDYTVRSLLLSKQGTLKEVRLIHQYqfTSWPHRGVPQQTAAllRFRKNIINRSP---HVPKSGPWIIHCSAGVGRTGIFLVID-AMLRQAKEKKVVDIYN
.|  |  .|   .|. |    .|.|   .|||  .| ....  .| |.| .      .  .| | .    .|.||.| | ... | |   .|.  .|. .
gdgwvlkvlsvsngdyksflhvhhy..kawphnsipsdgsp..kfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvk

YVYAIEEDRPYIIQTKDQYVFIHQTI
 .  . . | . .|   |. ...  .
clenvrngrlhavqnlsqfsvvytll
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 161-222 1.2e-14 48.5 In-house 2-63 (69) alignment 
Range on Protein: 161-222
Range on HMM: 2-63/69.0
IIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVYAIEEDRPYIIQTKDQYVFIHQTILE
..|||.| |||| |. |   . . | .|.|||.| |  .   || ..  . .|.||| .. |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalve
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 154-221 2.3e-14 48.0 In-house 225-292 (297) alignment 
Range on Protein: 154-221
Range on HMM: 225-292/297.0
VPKSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVYAIEEDRPYIIQTKDQYVFIHQTIL
 |.. . ..||||||||.|. .  |..| . . |.. |.   .  . | |. ..|| .|. .... .|
mprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavl
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 161-222 2.8e-14 47.2 In-house 1-62 (69) alignment 
Range on Protein: 161-222
Range on HMM: 1-62/69.0
IIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVYAIEEDRPYIIQTKDQYVFIHQTILE
..|||.| |||| |. |   . . | .|.|||.| |  .   || ..  ...|.|||... |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalve
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 31-118 8e-14 45.8 In-house 237-321 (440) alignment 
Range on Protein: 31-118
Range on HMM: 237-321/440.0
TYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLiegNELKCHQYWPSTDQPATYGVLTVSLKKKEEFSDYTVRSLLLSKQGTLKEVR
..||.| ||.|.  |||..| . . | |.||  |   |.  |  |||   .  |.| .||  |  |..    ||.| |  .  ..|.|
afiatqmpldstvldfwrlvhdyristiimlnql...ndktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkykeevheir
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1-133 3.1e-12 40.7 In-house 109-235 (244) alignment 
Range on Protein: 1-133
Range on HMM: 109-235/244.0
DHSRVMLRGAGSGCDYINATYIkGFDGTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNElkchqYWPSTDQPATYG-VLTVSLKKKEEFS
| .|| |  .  |  ||||... |  |    || .| ||  .  |||.|. . .  |.|.|  . | .|     ||| ..    |   .||.|  ..|| 
dfnrvplskgsmgntyinasfv.gclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede.....ywpdseplewyeeditvtltdrdefk

DYTVRSLLLSKQgTLKEVRLIHQYQFTSWPHRGV
.     | .  .   .  . .  .| . ||  | 
nikasnleiesd.mneshqaltmfqisnwpsdgt
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 13-93 1.8e-11 37.9 In-house 89-166 (349) alignment 
Range on Protein: 13-93
Range on HMM: 89-166/349.0
GCDYINATYIKGFDGTP-KTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWpstdQPATYGVLTVSLK
  ||||| |.|    .. | ||| | || |. |||....  ..  ... |.   | .  ||..||    |  .|   || |.
lddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiyw....qelsysnitvklq
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 13-133 4e-11 37.3 In-house 12-126 (130) alignment 
Range on Protein: 13-133
Range on HMM: 12-126/130.0
GCDYINATYIkGFDGTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNElkchqYWPSTDQPATY-GVLTVSLKKKEEFSDYTvRSLLLSKQ
| .|||| .. |  |  . |. .| ||  .. |||.|. .    |.|.|  . | .|     ||| ..    |   ..|.| ...||      | |  ..
gntyinasfv.Gllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede.....ywpdsePlewyeediivtltdrdefknik.asnleies

GTLKEVRLIHQYQFTSWPHRGV
   .  . .  .| . ||  | 
dlneshqaltmfqisnwpsdgt
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 119-220 9.6e-11 36.0 In-house 216-340 (350) alignment 
Range on Protein: 119-220
Range on HMM: 216-340/350.0
LIHQYQFTSWPHR---GVPQQTAALLRFRKNIINRS---P--HVPKSGPWIIHCSAGVGRTGIFLVIDAMLRQA-------KE-------KKVVD-IYNY
 ..| |.  |.       |..    |  ....|.        .  .| | ..||||||||||... .| .| .        ||       .|. | |   
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

VYAIEEDRPYIIQTKDQYVFIHQTI
|  . . |  ..|..||..||....
vnelrkqrismvqnldqfifiYeal
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 15-61 6e-08 26.6 In-house 71-116 (347) alignment 
Range on Protein: 15-61
Range on HMM: 71-116/347.0
DYINATYIKgFDGTPKTYIAAQGPLESSCDDFWQMVWQEKCSVIVML
 ||||..|| || . | || .| || ..  |||.||   | . .| .
tyinashik.fdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 155-190 5.8e-07 23.1 In-house 263-300 (349) alignment 
Range on Protein: 155-190
Range on HMM: 263-300/349.0
PKSGPWIIHCSAGVGRTGIFLVIDAMLR--QAKEKKVV
 .. . ..||||| ||||..  .| .|   .  ... .
dqlstllvhcsaGcGrtGvlvtldlllsileplqnesn
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1-64 1.1e-06 22.4 In-house 47-110 (332) alignment 
Range on Protein: 1-64
Range on HMM: 47-110/332.0
DHSRVMLRGAGSGCDYINATYIKGFDGTpKTYIAAQGPLESSCDD-FWQMVWQEKCSVIVMLTGL
||||| |       |. ||... |.     .|| || |..   .  ||.|| . | |.|...  .
dhsrvelapqdgkddfynaswvdgyskk.sayifaqapfndhteyvfwrmvserkpsmilvfgdi
subfamily_PTPDC1_pd Subfamily PTPDC1 158-218 6.9e-06 20.6 In-house 115-170 (182) alignment 
Range on Protein: 158-218
Range on HMM: 115-170/182.0
GPWIIHCSAGVGRTGIflVIDAMLRQAKEkkvVDIYNYVYAIEEDRPYIIQTKDQYVFIHQ
|   .|| || ||||.  .| ..|  ||.   ..  . .  . . ||  |||..|  ....
gkvavhChaGlGrtGv..liacylvyakr...ltaekaiklvrskrpksiqtreqvelvke