Gene NvecPTP-sf5-1 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily NvecPTP-sf5
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP062_AA protein Get Run
NvecP062_AA_12-288 phosphatase_domain Get Run
NvecP062_AA_300-573 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 6-508 2.4e-256 846.8 In-house 2-502 (564) alignment 
Range on Protein: 6-508
Range on HMM: 2-502/564.0
RQPIPVAELKQHYLRMHANSDLLFEKEYKDIKEPVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDsESTDYINANWIDGFKQEKKYIATIGPK
..||||||||.|. ...||||| ||.|||.|.|. ..|...... .||.|||| || |||||||.||.|.|| |..|||||..|||....|.||||.||.
skpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegd.egsDYINAsfidgyrkrkayIAtqgPl

AETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEE-NEQYGEIIVTLEEKEELADFEIRKFFLrKLSNQMETRMVKHFYFTSWPDHDVPEYATGL
|||..|||||.||..||..||||||.|||||||||||||. .|.|||..|||||.|||||.|||.|.| | ....|.|.|..|.|||||||.|||.||.|
aetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatsl

LEFWKRVRNSWeGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLRMRLM
|.....||...  |..|||.|||||||||||||||||||.|.||||...|.|.||...|.|||.|||...||.|||.|.|||...|.||.|..||...|.
Ldlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlq

QLAEKVAGTGMTGLEREFQLLNGAVPDELSDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFW
.|||....|.|||||.||| |..|...||..|..||.|||.||||..|||..|.|||||.||..||...||||||||.|.||.|||||||||.||.||||
kLaeveedtemtgleleFqrLatakeieleefavatkpknkkknrfsnilalescrvvlsairakeesdyinasyleayrekrafiatqaplkntvedfw

RMVWHEEVFCIVMLCGLNEPLEVFFSAIYTYLCWWGGGRWTLKKTNGVIVSEINFNPKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKHL
||||.|||..||||..|.|.||...|..|..|.....|..|.|.......|.|.|..|..||...|...||..|..||..||||.||...||.||.||.|
rmvweeevkiivmltkleekleeesseyysdleatkyGeitikvlkkkeksdilfrkkkvevkekseavyllhtvqavdkklltvidsvldllkavrkvl

DRPV
.|.|
erav
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 5-323 1.3e-169 558.3 In-house 1-319 (319) alignment 
Range on Protein: 5-323
Range on HMM: 1-319/319.0
TRQPIPVAELKQHYLRMHANSDLLFEKEYKDIKEPVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGdSESTDYINANWIDGFKQEKKYIATIGP
....|.|.|||... ....... |.|||.|..||.||.|...... .||.|||| ||.|||..||.||...| .|..|||||..|||.....|.|||..|
gdteievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldg.vegsdyinasfidgyqerekfiatqaP

KAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEEN-EQYGEIIVTLEEKEELADFEIRKFFLRKLSNQMETRMVKHFYFTSWPDHDVPEYATG
...|..|||||.||..|||||||||||||.|||..||||||| |.||..||||||.|||.|..|||..|.|.|...|||.||||..|.||||||||.||.
lentiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekats

LLEFWKRVRNSWEGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLRMRL
||...||.|.|.|..|||||.|||||||||||||||.|||.|..|||..|||.|.|||.|.|||.|||||.||.||..||||||..||||||||.||.||
lldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrl

MQLAEKVAGTGMTGLEREFQ
.|||||||.||.||||||||
kqlaekvadtgetglerefq
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 318-582 8.9e-127 417.6 In-house 25-294 (319) alignment 
Range on Protein: 318-582
Range on HMM: 25-294/319.0
LEREFQLLNGAVPDelsDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVM
||.||.||..||.|   .|..|....|.|||||.|||...|.||||......|...|||||...||||...||||||||.|||||||||||.||....||
lekefkllkeavnd...tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvm

LCGLNEPLEVFFSAIYTYLCWWGGGRWTL-----KKTNGVIVSEINFNPKTGEV--RQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKHLDRPVVV
|..|.|.|.|........ .....||...     ......|......|.|..||  |...||.|.||..|.||.|.....||.....|.|.|. ..|.||
ltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivv

HCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYLDSFE-ESQYQN
|||.||||||.|..|.|.|||||.|||||||.|...|||||. ||.. .||...|||.|....... | . |.
hCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqd
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 9-324 3.3e-113 372.9 In-house 2-317 (318) alignment 
Range on Protein: 9-324
Range on HMM: 2-317/318.0
IPVAELKQHYLRMHANSDLLFEKEYKDI-KEPVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDSEStDYINANWIDGFKQEKKYIATIGPKAE
|.| .|..|  |.... .||...||. . ... .||. .  . .|| |||| || ||||.|| |. ..|. .| ||||||.|||....|.|||. .| .|
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegs.DyinanyidGyrrkkayiaaqaPlpe

TTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEEN-EQYGEIIVTLEEKEELADFEIRKFFLRKlSNQMETRMVKHFYFTSWPDHDVPEYATGLLE
| .|||||.|| .|...||||...|.||.|.|.|||... ..||.. |.|.|. ||.|. .|.| ... ... |.|.|. . .|||||..||| ...||.
tieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtr.teeeesrqvrqyhytsWpdegvpesgaslld

FWKRVRNSWEGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLRMRLMQL
. ..|..  . .. |||.|||||||||||.||..|...|.||.|.|.||. .|...| ||| |||  .|| ||. .||||.. ||||.. ..|| |. .|
lvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirel

AEKVAGTGMTGLEREFQL
 |. . .|.| .. ||| 
reqdpesgttemdaefqr
subfamily_PTPRB_pd Subfamily PTPRB 5-288 2.2e-104 343.6 In-house 3-286 (293) alignment 
Range on Protein: 5-288
Range on HMM: 3-286/293.0
TRQPIPVAELKQHYLRMHANSDLLFEKEYKDIKEP-VNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDsESTDYINANWIDGFKQEKKYIATIG
. .|| . ....|. .|.|.||| | .||...|.   . ..   .. .|. |||| || .|||||| |...... ...||||||.|.|.......||| |
kskpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkde.sgsDYinanyipgynsprefiatqG

PKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEE--NEQYGEIIVTLEEKEELADFEIRKFFLRKlsnQMETRMVKHFYFTSWPDHDVPEYA
|  ||. |||||.||.||||.||||.|||||||||..|||..  . .||.| ||| ..||| |. ||.. ..|   ..|.| |... |||||||.||| .
PlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPekt

TGLLEFWKRVRNSW-EGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVT
. ||.|...||..  .  ...||.|||||||||||||| .| ....|.||...|... |...| .||..||  .|| ||| ..|. ..
ktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_PTPRA_pd Subfamily PTPRA 6-322 5.2e-103 339.4 In-house 11-330 (330) alignment 
Range on Protein: 6-322
Range on HMM: 11-330/330.0
RQPIPVAELKQHYLRMHANSDLLFEKEYKDIKE-PVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDsESTDYINANWIDGFKQEKKYIATIGP
  |.|| .|..   .  |.   || .|.. .   |.. |   ...  || |||. ||  ||.|||||| ..|  |..||||| .|||.|. .|.||. ||
yfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGv.eesdyinasfidGykekdkfiaaqGP

KAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEEN-EQYGEIIVTLEEKEELADFEIRKFFLRKLSNQM---ETRMVKHFYFTSWPDHDVPEY
|.||  |||||.||.||. .||||.| |. . ||..|||.|    ||.| |..|....| |. .||| ...|....   ..|.|. |.||||||  ||  
keetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfe

ATGLLEFWKRVRNSwEGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLR
. |.|.. |.|..  .  ..|||.|||||||||||||||.||..|..| |...||.  |.|.|.||  |||   || ||. .|||   .||||..|  | 
piGmlkllkkvkkl.nqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvssle

MRLMQLAEKVAGTGMTGLEREF
 .| .| .|..||  .||| ||
khlqklynkitgtdkigleeef
0051299 (Phosphotyrosine protein) phosphatases II 7-287 3e-101 333.9 In-house 3-286 (288) alignment 
Range on Protein: 7-287
Range on HMM: 3-286/288.0
QPIPVAELKQHYLRMHANSDLLFEKEYKDIKEPV-NVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGdSESTDYINANWIDGFKQEKKYIATIGPK
 .|.| || ...|...||.  ....|.... .   ..|....    |..|||| .| .||||||.||...| .|..|||||..|||.....|.||| ||.
teisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldg.vegsdYinAsyidgynlkrkfIatqgPl

AETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWP-EENEQYGEIIVTLEEKEELADFEIRKFFLRKLS---NQMETRMVKHFYFTSWPDHDVPEYA
 .|..|||||.||......||||||||.|..||..||| .. ..||.| ||| . |.|.|. .|.. ...|.    . |.|.|.||..|.||||.||...
pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

TGLLEFWKRVRNSWEgPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAV
. ||.|...||.. . ...||. ||||||||||||||..| ..||...|. .||...| |.| ||..||| |.|| |...||||..
ellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_PTPRG_pd Subfamily PTPRG 9-300 5e-101 333.6 In-house 1-300 (563) alignment 
Range on Protein: 9-300
Range on HMM: 1-300/563.0
IPVAELKQHYLRMHANSDLLFEKEYKDIKEPV---NVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDSESTDYINANWIDGFKQEKKYIATIGPK
.|| |...|   .||..|  |..|...... .   .... | ..  || |||| || |||.||| ||.. |  .. ||||||.|||....|..||| || 
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

AETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEE-NEQYGEIIVTLEEKEELADFEIRKFFLRKLS-----NQMETRMVKHFYFTSWPDHDVPE
..|. |||||.||....|.||.|.|||.|. ||. |||..  |.||.. |||.|.| ||   .|.. ...|      .. . ..|... .|.||||.|||
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPe

YATGLLEFWKRVRNSwEGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNL
...  | | |.   . .  . |||.||||||||||||.||.|....||..||  .|.  . .|||||||.||   || |.| |||||.. ..||.  ...
hslpvLifvkkssaa.nkaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqv

R
.
e
0040438 (Phosphotyrosine protein) phosphatases II 13-325 7.9e-101 332.7 In-house 4-314 (317) alignment 
Range on Protein: 13-325
Range on HMM: 4-314/317.0
ELKQHYLRMHANSDLLFEKEYKDIKEPVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGdSESTDYINANWIDGFKQEKKYIATIGPKAETTSDF
.|....|......  ....|..|. .    |...   . ||.|||| .|  ||||||.||...|  ...|||||...||... .|.||| ||. .|. ||
dlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplgg.dldsdYInAsyvdgpnlkrkfIatqgPlpntvedF

WRMMWEHKSSIVVMLTKLVEKGKVKCHKYWP-EENEQYGEIIVTLEEKEELADFEIRKFFLRKLsNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRV
|||.||......||||.|.|.|..||..||| .|  .||...||| . ||||....|.. . .| .  |.|.|.||..|.||||.||.. . ||.| ..|
wrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleav

RNSWEgPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLRMRLMQLAEKVA
|.. | ...||. ||||||||||||||... |.||...|. .||.. | ..|.||. .|| |.|| |...|||| .....| .....| ..|..| ...|
reale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllkllipla

GTGMTGLEREFQLL
...... |.|..||
lddvklkekelkll
0050432 (Phosphotyrosine protein) phosphatases II 8-291 1.6e-99 328.4 In-house 25-303 (308) alignment 
Range on Protein: 8-291
Range on HMM: 25-303/308.0
PIPVAELKQHYLRmhANSDLLFEKEYKDIKEPVN-VTTRHCDNLINKPKNRYGNIKAYDHSRVILssvqgdSESTDYINANWIDGF--KQEKKYIATIGP
...| .| ... .  |..  |.|.|.... .  .  .....    ||.|||| .| .||||||.|      .|..|||||...||.  |...|.||| ||
klsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl......degsdYInAsyvdgyssklprkfIatqgP

KAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEE----NEQYGEIIVTLEEKEELADFEIRKFFLRKLSNQmETRMVKHFYFTSWPDHDVPEY
. .|. |||||.||......||||||||.|..||..|||.|     ..|| . ||| . |.|.|. .|.. |..|... |.|.|.||..|.||||.||..
lpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg.esrtvthfhytnWpdhgvPps

ATGLLEFWKRVRNSWegpQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGD
.. ||.|...||.|    ..||| ||||||||||||||..| ..||...|. .||...| ..| ||..||| |.|| |...|||| . .  
peilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
0046845 (Phosphotyrosine protein) phosphatases II 31-294 2e-97 321.2 In-house 4-281 (284) alignment 
Range on Protein: 31-294
Range on HMM: 4-281/284.0
KEYKDIKEPVNV---TTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDSESTDYINANWIDGF-----KQEKKYIATIGPKAETTSDFWRMMWEHKSS
.|.. .   .     .....  . |. |||| .| .||||||.|.|..||.|..|||||...||.     ...||.||| ||. .|. |||||.||....
eefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvr

IVVMLTKLVEKGKVKCHKYWPEEN--EQYGEIIVTLEEKEELADFEIRKFFLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEG-PQ
..||||.|||.|..||..|||.|.   .||...||| ..|.  |. .|.. |..|.   |.|.|.||..||||||.||.... ||||.. ||.. |  |.
vIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpg

SGPITVHCSAGVGRTGTFIVIDAMMEQIKEEN---LLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEI
.||| ||||||||||||||..| ..||...|.    .||...|.|.| ||..||| ..|| |...||||.. .. | .
ggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltll
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 12-294 3.2e-96 317.1 In-house 12-297 (298) alignment 
Range on Protein: 12-294
Range on HMM: 12-297/298.0
AELKQHYLRMHANSDLLFEKEYKDIKEPVN----VTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDsESTDYINANWIDGFKQEKKYIATIGPKAE
| |..    .....   ...|.. ...  .     ...   .  || |||| .| |.|.|||.|.....| | .||||| .....|... .||| .|  |
aalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedad.eesdYiNAsflhaykgrnafiatqaPlte

TTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPE-ENEQYGEIIVTLEEKEELADFEIRKFFLRKLSNQmETRMVKHFYFTSWPDHDVPEYATGLLE
|..|||||..|.... .||||.|.|..|.|.|||||. ..|.|||| |.| .||| ||...||... | ... ..|.|... ||||||..|||.|| .|.
tvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvld

FWKRVRNSWEGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEI
. ..|| | .     |..|.|||||||.||||.||...|..|.|. .||. .| ..|..|  .||  .||.||..| |||.. ...||
llrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
subfamily_PTPRK_pd Subfamily PTPRK 9-323 5.1e-96 316.2 In-house 4-313 (314) alignment 
Range on Protein: 9-323
Range on HMM: 4-313/314.0
IPVAELKQHYLRMHANSDLLFEKEYKDIKEPVNVTTRHcDnliNKPKNRYGNIKAYDHSRVILSSVQGDSeSTDYINANWIDGFKQEKKYIATIGPKAET
| ||.| |.   ....    | .||. . |  ... .. .   |. |||.|.| |||.|||.| ...||. |.|||||..||..|. ...|.| ||. ||
irvadllqsiallkraegygfkeeyeslfegwdaakkd.e...nreknrsgdilaydrsrvflitidgdp.ssdyinaalidsykrpaafivtqgPlqet

TSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEENEQYGEIIVTLEEKEELADFEIRKFFLRKL-SNQMETRMVKHFYFTSWPDHDVPEYATGLLEF
. ||||........ .||||.|||.|.||| |||||. |.||.| |.| | | ||.. .| | ..||  .| |.|.|..| |..||||||| .|||||..
vkdfWrlvydencasivmltelvevgrvkClkyWPedtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllkl

WKRVRnSWEGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLRMRLMQLA
 .||  ... .. |.| |||||| |||||||.|| ... |..|...||.  |  .|...  ||.   || ||. ..|||.  |.| | | ...   ..  
vrrvk.ksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalylesi

EKVAGTGMTGLEREFQ
.  . |  . |. |||
rldpqtnssqlkeefq
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 7-306 4.5e-95 313.3 In-house 2-302 (305) alignment 
Range on Protein: 7-306
Range on HMM: 2-302/305.0
QPIPVAELKQHYLRMHANSDLLFEKEYKDIKEPVNVTTRHCdNLINKPKNRYGNIKAYDHSRVILSSVQGDSeSTDYINANWIDGFKQEKKYIATIGPKA
..| ...|...   ....||  .|..|| . |  . .  .. .  || |||. .|  .|..|.||.  . .   .|||||...||.|..||||.. ||  
kiialddlaayikearvysdkgleaqykslyeeeesidvgk.keankaknrlkeitlldddriiltekesld.dsdyinasyvdgykrkkkyivaqgPlk

ETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEENEQ---YGEIIVTLEEKEELADFEIRKFFLRKLSNQMETRMVKHFYFTSWPDHDVPEYATG
.| .||||...| | | .|||||||| || ||..||||.  .   .||..|.|..... .|. .||. . . ... |.| | .. .|.|||| ||..|| 
ntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfats

LLEFWKRVRNSWEGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLRMRL
||.. |||.....  .  |..|||||||||||.||..| ..|..|.|. .||. .. ..| .|  |||   || |.| || | .| |||.| ..|||.|.
llslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarv

MQL
 .|
nkl
0036941 (Phosphotyrosine protein) phosphatases II 19-302 1.4e-94 312.1 In-house 5-292 (297) alignment 
Range on Protein: 19-302
Range on HMM: 5-292/297.0
LRMHANSDLLFEKEYKDIKEPVNVTT-RHCDNLINKPKNRYGNIKAYDHSRVILssvqgDSESTDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMW
| .....  |..||.... .  .  . ..  .. |..|||| .| .|||.||.|     |.|..|||||...||.....|.||| ||. .|. |||||.|
llekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl.....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvw

EHKSSIVVMLTKLVEKGKVKCHKYWP---EENEQYGEIIVTLEEKEE--LADFEIRKFFLRKLSNQmETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVR
|......||||.|||.|..||..|||   .|  .||...||| . |.  |.|. .|.. . .. |. |.|.|.||..|.||||.|||... ||.|...||
eqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgng.esrtvthfhytgwpdhgvpespaslldfielvr

NSWEGP-QSGPITVHCSAGVGRTGTFIVIDAMMEQIK---EENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLRMR
.  .   ..||. |||||||||.||||..| |..|..   .|. .|....|  .| ||...|| ..|| |...|||| . ...| .....| ..
kvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllklvll
0045450 (Phosphotyrosine protein) phosphatases II 5-286 2.4e-93 308.5 In-house 5-303 (307) alignment 
Range on Protein: 5-286
Range on HMM: 5-303/307.0
TRQPIPVAELKQHYLRMHANSDLLFEKEYKDIKEPVN---VTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDSESTDYINANWI--------DGFK
. ..|..  | ...|......  ...||......       ....   . ||.|||| .| .|||.||.|||..|..|..|||||...        ||..
lslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgyd

QEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEENE--QYGEIIVTLEEKEELADFEIRKFFLRKLSNQMETRMVKHFYFTS
. .|.||| ||. ||  |||||.||......||||.|||.|..||..|||.|.|  .||.. ||| ..|.|... .|.. .  |.   |.|.|.||..|.
lkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytg

WPDHDVPEYATGLLEFWKRVRNSWEGP-QSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENL---LDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEA
||||.||..   ||.|...||.  |   ..||. ||||||||||||||... |..|...|.    .|... |...|.||  .|| |.|| |...|||| 
wpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
0039614 (Phosphotyrosine protein) phosphatases II 7-290 3.6e-93 307.5 In-house 12-292 (297) alignment 
Range on Protein: 7-290
Range on HMM: 12-292/297.0
QPIPVAELKQHYLRMHANSDLLFEKEYKDIKEPVNvTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDSESTDYINANWIDGFKQ-EKKYIATIGPK
 |||.  | ...|...|||  |...|...... .   ....    ||.|||| .| .||||||.|... |  ...|||||...||...  .|.||| || 
ipiplsvldlllllekansktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPl

AETTSDFWRMMWEHKSSIVVMLTKLVEKGKvKCHKYWPEENEQYGEIIVTLEEKEELADFEIRKFFLRKlsnQMETRMVKHFYFTSWPDHDVPEYATGLL
 ||. |||||.||......||||||||.|. ||..||||| ..||.. ||| . |.|... .|.. ...     |.|.|.|| .|.||||.||.... ||
petvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeeggtygdftvtllkvehldgytvrtlevtn...ngesrtvthfqytgwpdhgvppslelll

EFWKRVRNSWEGP-QSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFG
|| . ||.  .   ..||. ||||||||||||||... |.||...|  .||.. |...| ||. .|| |||| |...|||| . ..
eflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
0047943 (Phosphotyrosine protein) phosphatases II 18-286 5.6e-93 306.6 In-house 3-271 (273) alignment 
Range on Protein: 18-286
Range on HMM: 3-271/273.0
YLRMHANSDLLFEKEYKDIKEPVNVTT-RHCDNLINKPKNRYGNIKAYDHSRVILssvqgDSESTDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMM
.|......  |...|......  .. | ...    || |||| .| .||||||.|     .....|||||...||.....|.||| ||. .|. |||||.
lllekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl.....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmv

WEHKSSIVVMLTKLVEKGKVKCHKYWPEE----NEQYGEIIVTLEEKEELADFEIRKFFLRKLSNQMeTRMVKHFYFTSWPDHDVPEYATGLLEFWKRVR
||......||||.|||.|..||..|||.|     ..||...||| . |. .|. .|.. |..|...  .|.|.||..|.||||.||.. . ||||.. ||
weqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvr

NSWEGP-QSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEA
.  |   ..||. ||||||||||||||..| ...|...|. .||...| ..| ||  ||| |.|| |...|||| 
kalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
0043336 (Phosphotyrosine protein) phosphatases II 8-285 5.1e-92 303.5 In-house 1-275 (278) alignment 
Range on Protein: 8-285
Range on HMM: 1-275/278.0
PIPVAELKQHYLRMHANSDLLFEKEYKDIKEPVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGdSESTDYINANWIDGFKQEKKYIATIGPKAE
||.| .| ...|....|.  |...|.... .    |....  . ||.|||| .| .||||||.||...|  ...|||||...||... .|.||| ||  |
pisvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllgg.dldsdYinAsyvdgynvprkfiatqgPlpe

TTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEENEQYGEIIVTLEEKEELADFEIRKFFLRKLSNQMEtRMVKHFYFTSWPDHDVPEYATGLLEF
|. |||||.||......||||.|||.|.|||..|||.. ..||.. ||| . |.|.|. .|.. . .| .  . |.| |.....||||.|||  . ||.|
tvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdges.rtvthyhylgwpdhgvpeslsllldf

WKRVRNSWEgPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLE
 |.||.  | ...||. ||||||||||||||... ..||.. |  .|... |...| ||  .|| |||| |...||||
lkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
subfamily_Ptp69D_pd Subfamily Ptp69D 8-305 1.6e-90 298.4 In-house 3-304 (307) alignment 
Range on Protein: 8-305
Range on HMM: 3-304/307.0
PIPVAELKQHYLRMHANSDLLFEKEYKDIK-EPVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDSEsTDYINANWIDGFKQEKKYIATIGPKA
.|.. .|.. .   . ..| ...|||. .. . .. .|.  ..  |. |||| .|||.|. ||.|. ..|. . .|||||..| |.|..||.||  .|  
aiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingked.sdYinasfikgykekkkfiaaqdPve

ETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWP-EENEQYGEIIVTLEEKEELADFEIRKFFLRKLSNQM----ETRMVKHFYFTSWPDHDVPEYA
.|  |||||..| .. ..|||..| || . ||.|||| |.. |||.|.|.| ..|.  |. ||.. . |  ..     ..| |  . .|.|.|  ||| |
atigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPeva

TGLLEFWKRVRNSWEGpQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLRM
.|||.. ..||.  .  . .||.|||||||||.|.|. .| ...|.|.|. .|..  |  .| |||..||.  ||.|.. |||.  ..|||...|..|  
rgllklieqvrelykl.nrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddled

RLMQ
.. .
aier
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 48-288 3.9e-90 296.4 In-house 5-243 (250) alignment 
Range on Protein: 48-288
Range on HMM: 5-243/250.0
DNLINKPKNRYGNIKAYDHSRVILSSVQGDSEStDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVkCHKYWP-EEN
 .. || |||| .| |.|.|||.| ...|| || ||||| ...|....| .||| ||  .|. |||||..|.||. .||||.|.|..|. .|.||| |. 
kkpqnkeknryadiialdssrvvLekekgdkes.dyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPveka

EQYGEIIVTLEEKEELADFEIRKFFLRKLSNQmETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGPQSGPITVHCSAGVGRTGTFIVIDAMMEQ
|.||.. |.| .||| ||...||..| | ... . |.|... |..|||  |||.||  ||. |.|. | .  ...|. |.|||||||.|.||.|||..|.
ekyGdvtvsllskeefadytkrklklskakka.derivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavler

IKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVT
.|.|. .||. .. ..|..|  .|.  .||.|.. ..|.|..
lkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 14-287 2.3e-87 287.6 In-house 2-276 (281) alignment 
Range on Protein: 14-287
Range on HMM: 2-276/281.0
LKQHYLRMHANSDLLFEKEYKDIKE-PVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQgDSESTDYINANWIDGFKQEKKYIATIGPKAETTSDF
|..|  ....|..  | .||.....  |. |..   .  |. |||| || |||..|| ..  . ....|||||||...|.|.||.|||| ||  ..  .|
lrkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpne.enkntDYinanfvpgykgekeyiatqgPvPaslvaf

WRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEEN--EQYGEIIVTLEEKEELADFEIRKFFLrkLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKR
|.|.||.| |..||.|. .|.||.|||.|||..|   .||...|. ...|| | .  ||| |    .. ||| |... .|.|||| ||. .. |||| | 
WqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl..eresgetreveqlaytaWPdhGvPattkellefrke

VRNSWEGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEE-NLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAV
|..  |  .  |. .|||||||||||.| .| .......| . |||   |  .| .||.|||   ||.|.. |.|.|.
vlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 14-286 7.1e-87 286.1 In-house 9-278 (288) alignment 
Range on Protein: 14-286
Range on HMM: 9-278/288.0
LkQHYLRMHANSDLLFEKEYKDIkEPVNVTT--RHCDNLINKPKNRYGNIKAYDHSRVILSSVQgDSESTDYINANWIDGFKQEKKYIATIGPKAETTSD
. ..  ...|..   |..||. .  ... |       .  |..|||| || .||. || |  .. . ...|||||..||| |..|||||| || |.|  |
v.akvakksarnrtgfseeynsL.aalektksvtagrlavnakknRyrnilpyDekrvklkkle.eeagaDYinasyidgekkkkkyiatqgPladtvnd

FWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEENE--QYGEIIVTLEEKEELADFEIRKFFLRklsNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWK
||....|.|.| .||||.|||.|| ||..|||....  .||.. ||| |..|| ||  ||. |     ... . .... ...||||.||| .. |||. .
fWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellr

RVRNSWEGPqSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEA
 | .. .   .|||.||||||||||||||..||......||. .|| . |...| ||...||  .|| ||. .||. 
qvkvanqad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsl
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 6-322 1.3e-85 282.1 In-house 3-314 (315) alignment 
Range on Protein: 6-322
Range on HMM: 3-314/315.0
RQPIPVAELKQHYLRMHANSDLLFEKEYKDIKEPVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDSeSTDYINANWIDGFKQEKKYIATIGPK
.||||. .|  .  . .|..   |...|. |        .   .  || |||| || |||.||| |  .. |.  .||.|||.|||......|||. ||.
hqpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendp.hsdyvnanfidGynkkrryiaaqgpn

AETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEENEQYGEIIVTLEEKEELADFEIRKFflrKLSNQMETRMVKHFYFTSWPDHDVPEYATGLL
...  ||||...|.. . .||||.|||. | |. ||||...  ||.| ||. ..|   .. .| .       . . | |  . .||||| .||.|.. |.
vasvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviyGkitvtrkseevnteytvrtl...svvfgdnirevvqlhytswpdmgvpkytiplm

EFWKRVRNsWEGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEvQNLRMRLMQ
.. ..|.  ..  . |.| |||||||||||||| .||...|.. ||..||| .. ..|..|  |||   || ||. ||||..  ||| |  |.| .   .
nlirtvkq.hhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsia.qdlylqryd

-LAEKVAGTGMTGLEREF
 |      || | |. .|
sllapspdtgstllqeqf
DSPc_SM00195 29-287 1.4e-84 278.9 In-house 2-262 (263) alignment 
Range on Protein: 29-287
Range on HMM: 2-262/263.0
FEKEYKDIKEPV-NVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDsESTDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVML
...|.....|   . .|.. .   || |||| ||. |||.||.|.. ... |..||||||.|.| ...|||||| ||. .| .|||||.||.|..|.|||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk.egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

TKLVEKGKVKCHKYWPEE---NEQYGEIIVTLEEKEELA-DFEIRKFFLRKLSNqMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGPqSGPI
|. .|.|| ||..|||||   .|..|.| |.| |.|.   ....|.. |.|  .  ||| |... ...||||.||. .. .||. . |..| .   ||||
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpi

TVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAV
 |||||||||||||..|| ......||. .|. . |...| ||  |||   ||.||. |.||..
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 29-287 1.4e-84 278.9 In-house 2-262 (263) alignment 
Range on Protein: 29-287
Range on HMM: 2-262/263.0
FEKEYKDIKEPV-NVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDsESTDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVML
...|.....|   . .|.. .   || |||| ||. |||.||.|.. ... |..||||||.|.| ...|||||| ||. .| .|||||.||.|..|.|||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk.egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

TKLVEKGKVKCHKYWPEE---NEQYGEIIVTLEEKEELA-DFEIRKFFLRKLSNqMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGPqSGPI
|. .|.|| ||..|||||   .|..|.| |.| |.|.   ....|.. |.|  .  ||| |... ...||||.||. .. .||. . |..| .   ||||
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpi

TVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAV
 |||||||||||||..|| ......||. .|. . |...| ||  |||   ||.||. |.||..
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
Y_phosphatase Protein-tyrosine phosphatase 52-285 3.6e-84 277.2 Pfam-A 1-235 (235) alignment 
Range on Protein: 52-285
Range on HMM: 1-235/235.0
NKPKNRYGNIKAYDHSRVILssvQGDSESTDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWP---EENEQ
|| |||| .| .||..|| |   .|.....||||||...|.|..||.||| ||  .| .|||||.|..|....||||.|.|||..||..|||   || ..
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGEIIVTLE--EKEELADFEIRKFFLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWeGPQSGPITVHCSAGVGRTGTFIVIDAMMEQ
||.| |.|.  |||. ... .||. |.|  .. |.|.||.. .|.||||.||| ...||.. ..|..|   ..|||..|||||||||||||...|...||
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleq

IKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLE
...|. .||...|...|.||. |||. .|| |.. |.||
leaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 52-285 3.6e-84 277.2 In-house 1-235 (235) alignment 
Range on Protein: 52-285
Range on HMM: 1-235/235.0
NKPKNRYGNIKAYDHSRVILssvQGDSESTDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWP---EENEQ
|| |||| .| .||..|| |   .|.....||||||...|.|..||.||| ||  .| .|||||.|..|....||||.|.|||..||..|||   || ..
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGEIIVTLE--EKEELADFEIRKFFLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWeGPQSGPITVHCSAGVGRTGTFIVIDAMMEQ
||.| |.|.  |||. ... .||. |.|  .. |.|.||.. .|.||||.||| ...||.. ..|..|   ..|||..|||||||||||||...|...||
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleq

IKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLE
...|. .||...|...|.||. |||. .|| |.. |.||
leaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
0045098 (Phosphotyrosine protein) phosphatases II 42-287 8.5e-83 273.2 In-house 23-272 (278) alignment 
Range on Protein: 42-287
Range on HMM: 23-272/278.0
VTTRHCDNLINKPKNRYGNIKAYDHSRVIlssvqgdsestDYINANWIDGFkqEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKY
 .  .   | |..|||| .| .||||||.           |||||..|||.   ||.||| ||. .|..|||||.||......||||.|||.|..||..|
seitpalylgnldknRykdilpydhsrVk...........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqy

WPEEN-EQYGEIIVTLEEKEELADFEIRKFFLRKL---SNQMETRMVKHFYFTSWPDHDVPEYA--TGLLEFWKRVRNSWE------------GPQSGPI
|||.. ..||.. |||.. |.| |. .|.. .. |    .  |.| |.|.....||||.||..   . .||.....|.  .             ...||.
wpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpv

TVHCSAGVGRTGTFIVIDAMMEQIkeENLLDVYSYVSRIRAQRNF-MVQRPSQYSFIHYALLEAV
 ||||||||||||..... |.|..  |. .|....|. .| ||.. .|| ..|| |....||| .
lVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_PTPN9_pd Subfamily PTPN9 29-285 1.6e-82 271.9 In-house 18-288 (297) alignment 
Range on Protein: 29-285
Range on HMM: 18-288/297.0
FEKEYKDIK-EPVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDsESTDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVML
  |||..|. |||. |  .     |  |||| ..  ||..|| |..|..| | .||||||..||.||.| .||| ||  .|.||||||.||..  ..|| 
lskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvded.easdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmt

TKLVEKGKVKCHKYWP---EENEQYGEIIVTLEEKEELADFEIRKFFLRKLSNqMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRN-----------
|..||.|..|| .|||   |. ...|.. |.  | ||  |...|.. ...  .  |.| | || |.||||. ||. |. ||.. . ||.           
trvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkt.eesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgd

SWEGPQSG-PITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLE
.|.|. || || ||||||.||||||| .|  .....|.. .||   |...|.|| |..| | || | . |.||
ewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
0040439 (Phosphotyrosine protein) phosphatases II 46-286 4.2e-82 270.7 In-house 5-245 (249) alignment 
Range on Protein: 46-286
Range on HMM: 5-245/249.0
HCDNLINKPKNRYGNIKAYDHSRVILSSVQGdSESTDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWP-E
..  . ||.|||| .| .||||||.||...|  . .|||||..|||... ...||| ||  ||..|||||.||......||||.|||.|..||..||| .
vallpenkdknrypdilpydhsrvklsilpg.lflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplg

ENEQYGEIIVTLEEKEELADFEIRKFFLRKLsNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGP-QSGPITVHCSAGVGRTGTFIVIDAM
.  .||.. ||| . |...|. .|.. | .|    |.|.|.|...|.||||.||..   ||.|...||.  |   ..||. ||||||||||||||... |
gsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylm

MEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEA
.||...|. .|....|. .| ||. .|| |.|| |...|||| 
leqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 15-309 8.5e-81 266.7 In-house 21-313 (319) alignment 
Range on Protein: 15-309
Range on HMM: 21-313/319.0
KQHYLRMHANSDL-LFEKEYKDI-KEPVNVTTRHCDNL-INKPKNRYGNIKAYDHSRVILSSVQGDsESTDYINANWIDGFKQEKKYIATIGPKAETTSD
.|   . ... ||  .| |.. . | .|| ...   ||  || |||..|| |.|...| |  ..|  | .||||| ...|.....||||. ||. .|  |
qqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGe.efsdyinasfvtGyqrkdkyiaaqGPldntlad

FWRMMWEHKSSIVVMLTklvekgKVKCHKYWPEE-NEQYGEIIVTLEEKEELADFEIRKFFLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKR
||||.||...| .|.||      | || .||| . ......  | ..  || |.. .|.. | . ... . | .. |.|  |||. ||.|.. |. . |.
fWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkk

VRNSWEGP-QSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLRMRLMQLAEK
||   .   .  .| |||||||||||..||.|......|||. .||| .|  .| ||| .||   || ||. ||||   || ... . ..   | .|..|
vrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleelsnk
0042113 (Phosphotyrosine protein) phosphatases II 49-285 2.3e-80 264.8 In-house 6-241 (245) alignment 
Range on Protein: 49-285
Range on HMM: 6-241/245.0
NLINKPKNRYGNIKAYDHSRVILSSVQGdSESTDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWP-EENE
 . ||.|||| .| .|||.||.||...| .. .|||||...||... .|.||| || .||. |||||.||......||||...|.|.|||..||| .|  
lpenkdknrysdilpydhtrvklspdgg.dldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesl

QYGEIIVTLEEKEELADFEIRKFFLRKLsNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGPQSGPITVHCSAGVGRTGTFIVIDAMMEQI
.||...||| . | |.|. .|.. . .|    |.|.| |.....||||.||..   ||.| ..||.  . ...||. ||||||||||||||... |.||.
tygdftvtllseehlddytvrtlevtnl.gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleql

KEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLE
..|  ..... | ..| ||  .|| |||| |...||||
ekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 7-324 3.9e-79 260.7 In-house 1-314 (315) alignment 
Range on Protein: 7-324
Range on HMM: 1-314/315.0
QPIPVAELKQHYLRmhANSDLLFEKEYKDIKEPVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQgDSESTDYINANWIDGFKQEKKYIATIGPKA
||||||..     .       || .|..|. .|    .| . . || .||||.||  .|..||.|  .. ||   |||||  | .....| |||. ||. 
qpipvaqfpafvnk..nrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvklevid.dsPdsdyinasyiksvdddkayiasqgPlk

ETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPE---ENEQYGEIIVTLEEKEELADFEIRKFFLRKlsnQMETRMVKHFYFTSWPDHDVPEYATG
 . .|||||....| . .||.||. |  |.|| .|||.   .  ..|.| |.| . |  .|  .||. .||     |.| |  | || |||. |.. .. 
asvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrk...seesrtvtqfqftewPdkGvdkqtss

LLEFWKRVRNSwEGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLRMRL
||.. | |. . .|..  .. ||||||||||| .| || ...|||... .||. .|  .||.| ..||   .|.||. |.|| . . .| | | ..  .|
llklikevkad.ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhl

MQLAEKVAGTGMTGLEREFQL
 .|   | |.| . . .||. 
qdlhtsvdgsgrskmtkefet
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 33-309 1.2e-78 259.5 In-house 4-277 (284) alignment 
Range on Protein: 33-309
Range on HMM: 4-277/284.0
YKD-IKEPVNVTTRHCDNL-INKPKNRYGNIKAYDHSRVILSSVQGDsESTDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTkl
..   | .|| |..   ||  || |||.|.| |.|...| |  ..|  | .||||| .| |.....||||| ||. .|  |||||.||...| .|.||  
frracklgvngtdqtfanldqnkdknrighilafdknvvklerliGe.efsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt..

vekgKVKCHKYWPEE-NEQYGEIIVTLEEKEELADFEIRKFFLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGP-QSGPITVHCS
    | || .||| . ......  | ..  || ... .|.. | . ... . | .. |.|  |||. ||.|.. |. . |.||   .   .  .| ||||
....kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcs

AGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLRMRLMQLAEK
|||||||..||.|......|||. .||| .|  .| ||| .||   || ||. ||||   || ... . ..   | .|..|
agvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleelsnk
0037934 (Phosphotyrosine protein) phosphatases II 49-285 4.3e-78 257.5 In-house 7-240 (243) alignment 
Range on Protein: 49-285
Range on HMM: 7-240/243.0
NLINKPKNRYGNIKAYDHSRVILssvqgdsESTDYINANWIDGFKqekKYIATIGPKAETTSD----FWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPe
 . |..|||| .| .||||||.|       |..||||||.|....   ..||| ||  ||. |    ||||.||......||||.|||.|..||..||| 
lpenlsknrysdilpydhsrvkl.......egsdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.

ENEQYGEIIVTLEEKEELADFEIRKFFLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEG-------PQSGPITVHCSAGVGRTGTF
....||...||| . |.|.|. .|.. |. |. . .||.| |.....||||.||.  . ||.|.. ||.  |        ...||. ||||||||||||.
gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtl

IVIDAMMEQIkeeNlLDVYSYVSRIRAQRNF-MVQRPSQYSFIHYALLE
|... |....   . .|....| ..|.||.. .|| |||| |...||||
iaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 52-285 1.3e-77 255.2 In-house 3-237 (237) alignment 
Range on Protein: 52-285
Range on HMM: 3-237/237.0
NKPKNRYGNIKAYDHSRVILSSVQGDsesTDYINANWIDGFKQ-EKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEEN--EQ
|| |||||||.|||||||.|    ..   .|||||....||    |||||. ||   .  |||.|.|. | |..|||| |.|. ..|||||||. .  . 
nkiknrygnivaydhsrvvlkgagsg...sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGEIIVTLEEKEELADFEIRKFFLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEG-PQSGPITVHCSAGVGRTGTFIVIDAMMEQI
|| . |.|  |||..|. .| . | |  .. | |... . ||||||. ||.... || | |.. |  .  ..|||  .|||||||||| |.|||||. | 
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

KEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLE
||....|.| ||  |  .| ...|   || ||| ..||
kekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_PTPN6_pd Subfamily PTPN6 29-285 1.4e-77 255.7 In-house 28-295 (306) alignment 
Range on Protein: 29-285
Range on HMM: 28-295/306.0
FEKEYKDIK--EP-VNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSsvQGDSESTDYINANWIDG--FKQEKKYIATIGPKAETTSDFWRMMWEHKSSI
||.|.....  |    .. .. .   || |||| ||  .||.||||.  . .   .|||||| |..   ...|.|||| |   .| ||||||.|. .| .
feeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk..epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrv

VVMLTKLVEKGKVKCHKYWPEEN--EQYGEIIVTLEEKEELADFEIRKFFLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGPQ--
.||.|| ||.|| || .|||.|.  |.||.| ||  ....|||...|.. . | ... |.| | .. |.|||||.||.    .|.|.. |..  |  .  
ivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleea

-SGPITVHCSAGVGRTGTFIVIDAMMEQIKEENL---LDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLE
 .||| ||||||.||||||||||.....|... |   .|... |  .|.||. .||  .|| |...|. .
eagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikk
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 290-577 3.2e-77 254.7 In-house 1-295 (298) alignment 
Range on Protein: 290-577
Range on HMM: 1-295/298.0
GDTEIEVQNLRMRLMQLAEKVAGTGMTGLEREFQLLNGAVPdELSDF--YTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKV
|.||||...|.. | .||..   ...||.. ||| ||     |. ..    | .|.| |||||..|.. . .|||| .. ..|...|||||.|..|... 
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvss.eieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn

AFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEPLEVFFSAIYTY--LCWWGGGRWTLKKT---NGVIVSEINF-NPKTGEVRQISHFMYLEWTEHA
||||||||| .|.|||||||..|.. .||||  |.|  .. ..  .       .|  . .|...     .|| ...  . |. . |.. .. . .|....
afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkg

VPTKLLTIIDLIGDLQKARRKHLDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYLDSFEE
||..  ...||. . .. ...  ..||.|.||.||||.|.|. . . ||||| | |.||| . ..||..|||.|   .||  .|||.| .||||..
vpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnd
0051299 (Phosphotyrosine protein) phosphatases II 291-572 1.7e-76 252.7 In-house 2-286 (288) alignment 
Range on Protein: 291-572
Range on HMM: 2-286/288.0
DTEIEVQNLRMRLMQLAekvaGTGMTGLEREFQLLNGAVPDelSDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFI
||||.|..|. ....|      .|.|||..||. |    ||   ....|  |.| .||||..|||....||.|  ... |...||||||..||. | .||
dteisveellklvlkll....angltglleefeellsllpd..ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfI

ATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEplevfFSAIYTYLCWWGGGRWTLKK----------TNGVIVSEINFNP-----KTGEVRQISHFMYL
|||.||.||.||||||||...| .||||..| |     .. .  . .|  || .|...           ....| ..   .     ..||.|.. || |.
atqgPlpntvedFWrmvweqnvrvIvmltklve.....lgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhyt

EWTEHAVPTKLLTIIDLIGDLQKARRkHLDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYL
 | .| ||. .  ..|.. ...||.. . . |||||||.||||||.|..|.  ||... ||..||. . ..||.||||||  ..|||..|||.| ||
nwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 8-332 2.5e-76 251.8 In-house 1-321 (515) alignment 
Range on Protein: 8-332
Range on HMM: 1-321/515.0
PIPVAELKQHYLRmhANSDLLFEKEYKDIKEPVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQgDSESTDYINANWIDGFKQEKKYIATIGPKAE
|.|.|..   . .  ..   || .|..|.  |       ... || .||||.||  || .||.|  .. |.   ||.||  | .|. .| |||. ||.  
plplaqfPafvnk..nrhttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevin.dnPhsdyfnasyipsfdndkayiasqgPnka

TTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPE---ENEQYGEIIVTLEEKEELADFEIRKFFLRKLSNqmeTRMVKHFYFTSWPDHDVPEYATGL
...||||...... . ..|.||| |  |.|| ||||.   .  ..|.| | |   |  ..  .||. . | ..   .| |  | || |||. ||. .. |
svddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd...srtvtqfhfteWPdkGvpkhtssl

LEFWKRVRNSWeGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLRMRLM
| . | |. .  |  . |. .|||||||||| .| || .. ..|. . .||. .|  ||..| ..||   ||.||. |.|| . . .| | |  .   | 
lklikevkadh.gqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlq

QLAEKVAGTGMTGLEREFQLLNGAVPDE
.|     | | . . .||| |.  .|| 
dlhssgdgrgrskmtkefqtlkslcpdp
0050432 (Phosphotyrosine protein) phosphatases II 285-575 1.8e-75 249.5 In-house 10-302 (308) alignment 
Range on Protein: 285-575
Range on HMM: 10-302/308.0
EAVTFGDTEIEVQNLRMRLMQLAEK-VAGTGMTGLEREFQLLNGAVPdeLSDFYTATQPKNSKKNRYPNILPCERCRVVLpaipdKEDTTYINASYLEGY
|...|.||.| | .|......|...    .....||.||. |.   |  | ....| .|.| .||||..|||....||.|     .|...||||||  ||
elllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkp..lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgy

--QEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEplevfFSAIYTYLCWWGG--------GRW-----TLKKTNGVIVSEINFNP-KTGEVR
    . .|||||.||.||.||||||||...| .||||. | |      . .  .  |           |..       .. ....| ..   . ..||.|
ssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklve.....ngrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesr

QISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKhldRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEA
.. || |. | .| ||...  ..|..  ..| ...    |.|||||.||||||.|..|   ||... || .||| . ..||.||||||  ..||...|.|
tvthfhytnWpdhgvPpspeilldflelvrkslpg...gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyra

ILAYLDSF
.| || ..
lleylklk
subfamily_PTPN12_pd Subfamily PTPN12 37-287 4.2e-75 247.3 In-house 25-277 (290) alignment 
Range on Protein: 37-287
Range on HMM: 25-277/290.0
KEPVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDSeSTDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKV
|.   ..| . ..  |. |||| .|  ||.||| ||  ...    ||||||.| | .....|||. || ..| .|||||.||.. .||||. ..|| || 
kaekvysteagekeenvkknrykDilPydksrvelskieeee.gsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkk

KCHKYWPEE---NEQYGEIIVTLEEKEELA-DFEIRKFflrKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEgPQSGPITVHCSAGVG
||..|||||   . ..||. |||||.. .  || || .   |. .| |.|.|. | .|.||||.||. |. |||. . ||.  |  .. |. ||||||||
kCerYWpeegeeelefgefevtleeekavdddflirtL...kveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvG

RTGTFIVIDAMMEQIKEENL---LDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAV
|||| |.|| . |..|.|..   |||.. | ..| ||. .||   ||.... |..| |
rtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
0046845 (Phosphotyrosine protein) phosphatases II 317-574 1.1e-74 246.7 In-house 1-276 (284) alignment 
Range on Protein: 317-574
Range on HMM: 1-276/284.0
GLEREFQLLNGAVPDELSDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDK-EDTTYINASYLEGY-----QEKVAFIATQAPLDNTIEDFWRMVWHE
|||.||. |.  ... | ....|  |.| .||||..||| ...||.|  .... ||..||||||..||       | .|||||.||.||.||||||||..
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

EVFCIVMLCGLNEplevfFSAIYTYLCWWGGG-R----------WTLKKTNGVIVSEINFNPK--TGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQ
.| .||||..| |     .. .  .  |   |            .  .. ....| ..   ..  |||.|.. || |..| .| ||. .  ..... ...
nvrvIVmltelve.....ngrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvr

KARRK-HLDRPVVVHCSDGVGRTGAFCTLFATLERVKLEG---VLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYLDS
..... . . |.|||||.||||||.|..|   ||... ||   ..||. . ..||.||||||  |.|||..|||.| || .
ellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 29-284 2.1e-74 245.0 In-house 7-265 (274) alignment 
Range on Protein: 29-284
Range on HMM: 7-265/274.0
FEKEYKDIkePVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDSESTDYINANWIDGFKQ-EKKYIATIGPKAETTSDFWRMMWEHKSSIVVML
.|||. ..  |.|..... |   .. |||| .|   ..|||.|.| ....| ..|||||.| |... .| |.|| || ..| .|||||.........|||
lekeflel..PlnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivml

TKLVEKGKVKCHKYWPEENEQ-----YGEIIVTLEEKEELADFEIRKFFLRKLSNqmeTRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGP--QS
||| |. . ||..|.|....      ||.. .. |.. |  |...||. |..|..   .| |||...|.||||..|. |. ||.. . |..| |    . 
tklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeenakl

GPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALL
.|. ||||||.|||| || |.  . |..||. .|| . |. .| .|  |||  .|| .|| || 
apvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 5-297 2.2e-73 242.0 In-house 6-294 (297) alignment 
Range on Protein: 5-297
Range on HMM: 6-294/297.0
TRQPIPVAELKQhYLRMHANSDlLFEKEYKDIKEPVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDsESTDYINANWIDGFKQekKYIATIGP
 |.|||....   ...   ..| .|..|.... |    ..   .. .| .|.|| ||  || |||.| .|. |  . ||.|| .. |.|.  ..|.|  |
errpiplsdfat.lvqknrhtd.vfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivndd.pdsDyvnasfvkgnkh..rlittqmP

KAETTSDFWRMMWEHKSSIVVMLTKLVEKGKvKCHKYWPEEN-EQYGEIIVTLEEKEELADFEIRKFFLRKlSNQMETRMVKHFYFTSWPDHDVPE--YA
. .|  |||.|..... |..|||... |. | || .||...   ..|.. |.|.  .|   |  |.. ..| ..   .|.|| . |..|||..|..   |
mkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtk.gkakarrvvkqyqfveWPdkaverkdsa

TGLLEFWKRVRNSWEGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQ
. ||.. . ||..... ..||. |||.||||||| .. || .. ..|.|. .|.. .|...| .| ..||   ||.|.. |.|||.   ||.|...
ssllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqas
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 50-286 1.8e-72 238.4 In-house 5-239 (239) alignment 
Range on Protein: 50-286
Range on HMM: 5-239/239.0
LINKPKNRYGNIKAYDHSRVILSSVQGDSEStDYINANWIDGFKQ-EKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEENEQ
 .|| |||| || .||||||.|  .  |  | |||||...  .    | |||| |  . .. |||||||. .  ..|||| |.|  | |||.|||.   .
rvnkaknryanivtydhsrvvleklsndphs.dyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk

YGEIIVTLEEKEELADFEIRKFFLRKLsNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSwEGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIK
| .. ||| . | .||. || | . ..  | | | | ...|| |||. ||.||| .| . ... .    | . |  .||||||||||.|.|||||. | |
ycnlrvtlrktevfadyiirtfvmsqv.gqteeryvyqyhftvwpdkgvpqyatavlglrrkitkd.slpgarpwvihcsagvgrtgaflvidamlrqak

EENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEA
... .|.. ||  || .| .|||   || ||| |.|||
kqktvdifnyvkairedrphmvqtseqyvfihlavlea
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 50-285 6.9e-72 236.4 In-house 6-239 (239) alignment 
Range on Protein: 50-285
Range on HMM: 6-239/239.0
LINKPKNRYGNIKAYDHSRVILSSVQGDSEStDYINANWIDGFKQ-EKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEENEQ
 .|| |||| || .||||||.|  .  |  | |||||...  .    | |||| |  . .. |||||||. .  ..|||| |.|  | |||.|||.   .
rvnkaknryanivtydhsrvvleklsndphs.dyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk

YGEIIVTLEEKEELADFEIRKFFLRKLsNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSwEGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIK
| .. ||| . | .||. || | . ..  | | | | ...|| |||. ||.||| .| . ... .    | . |  .||||||||||.|.|||||. | |
ycnlrvtlrktevfadyiirtfvmsqv.gqteeryvyqyhftvwpdkgvpqyatavlglrrkitkd.slpgarpwvihcsagvgrtgaflvidamlrqak

EENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLE
... .|.. ||  || .| .|||   || ||| |.||
kqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_PTPN3_pd Subfamily PTPN3 41-286 4.2e-71 234.1 In-house 30-274 (280) alignment 
Range on Protein: 41-286
Range on HMM: 30-274/280.0
NVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSvqgdSEStDYINANWI----DGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKV
.... ..    | .|||| .| .||. ||.|..    ||. ||||||..    .. .. ..|||| || |.|..|||.|.||.|||..|||| |||.|.|
glaisaarkpenlsknryrdilpydatrvklke....set.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrv

KCHKYWPEENE--QYGEIIVTLEEKEELADFEIRKFFLRKlSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGpQSGPITVHCSAGVGRT
|||.||||...  .|||. |..|...|   . .|.. |.. ... | |.. .. ...||||.||. .. .||| .|||.  .| .. |. ||||||.|||
kChqyWPetedeleygefsvkcekedetksyvlrelvlkd.ketkeerkilqlqylaWpdhgvPddsadflefvervrklrsg.keePvvvhCsaGigrt

GTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEA
| .|...  .  | ... . .   |...| ||  .|| .||| |.  |.|..
GvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
0040438 (Phosphotyrosine protein) phosphatases II 308-572 4.9e-71 234.9 In-house 10-276 (317) alignment 
Range on Protein: 308-572
Range on HMM: 10-276/317.0
EKVAGTGMTGLEREFQLLNGAVPDelsDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMV
...   ..|.|..||. |    .|   .. .|  |.| .|||||.|||....||.|  ..  .|..|||||| .|...| .|||||.||.||.|||||||
ldllksdftalleefedllslkld...tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmv

WHEEVFCIVMLCGLNEplevfFSAIYTYLCWWGGGRWT----------LKKTNGVIVSEINFNP-KTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDL
|.. | .||||. | |     .. .  .  |  |. .|           .. .|... .. . . ...|.|.. || |. |..| ||  . ...|..  .
weqgvtvivmLtelee.....lgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleav

QKARRkHLDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYL
..|.. . . ||.||||.||||||.|....  ||... || .||. . ..|| ||||.|  ..||| .|.|.| ||
reale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
0047943 (Phosphotyrosine protein) phosphatases II 313-572 1.5e-70 233.1 In-house 9-272 (273) alignment 
Range on Protein: 313-572
Range on HMM: 9-272/273.0
TGMTGLEREFQLLNGAVPdeLSDFYTATQPKNSKKNRYPNILPCERCRVVLpaipDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEV
.|.|.|..||.||    |  | ....|  |.| .||||..|||....||.|    . ... ||||||..||. | .|||||.||.||.||||||||.. |
lgltllleefelllslkp..lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv

FCIVMLCGLNEplevfFSA--IYTYLCWWGGG-----------RWTLKKTNGVIVSEINFNP-KTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQK
 .||||. | |      .    . |   .||.            .  .. ....| ..   . .|||.|.. || |..| .| ||. |  ....| ...|
rviVmLtelve.....lgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrk

ARRKH-LDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYL
|...   . |||||||.||||||.|..|.  |.... || .||. . ..||.||||||  ..|||..|||.| ||
alealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 11-323 1.8e-70 232.7 In-house 7-324 (325) alignment 
Range on Protein: 11-323
Range on HMM: 7-324/325.0
VAELKQHYLRMHANSDLLFEKEYKDIKEPVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSvQGDSESTDYINANWIDGFKQEKKYIATIGPKAETTS
| .| .|  . .|. .  | .|.. .     .. .      || |||. |. |.|.|||.| . ..|. |.|||||...  .|. . ..|.  |...|. 
vvnlvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvlet.kkddpssdyinasylrddkkkdvflaaqaPltatin

DFWRMMWEHKSSIVVMLTKLvEKGKVKCHKYWPEE---NEQYGEIIVTLEEKEELADFEIRKFFLRKLSnQMETRMVKHFYFTSWPDHDVPEYATGLLEF
|.||.. . ..|.||.| .| ..|| .| .|||.|     ..| . | |   ||..|.  |.. ... . . ||| || | . ||.|  |... . |. .
dlWrlvldWrcsvvvvlnel.dlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvk.kGetrsvkqfqlqswddmGvqkrpatlisi

WKRVRNSWEG-----PQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLRMR
 . | .  |        |.|| |||||||||||.|| . ...... ||  .|.. .| ..|..|  ||.   ||..|. || ||.  |.|.. | ..  .
lqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeak

LMQLAEKVAGTGMTGLEREFQ
|  | |.   |    .|.||.
lsslqernpltqklniekefe
0036941 (Phosphotyrosine protein) phosphatases II 313-572 2e-70 232.7 In-house 10-277 (297) alignment 
Range on Protein: 313-572
Range on HMM: 10-277/297.0
TGMTGLEREFQLLNGAVPdeLSDFYTATQPKNSKKNRYPNILPCERCRVVLpaipDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEV
.....|..||. |    .  | ....|  |.| .||||..|||....||.|    |.|.. ||||||..||. | .|||||.||.||.||||||||.. |
lflalllkefeellplll..lgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnv

FCIVMLCGLNEpleVFFSAIYTYLCWWGGGRWTLkktNGVIVSEINFNP----------------KTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDL
 .||||. | |     .   . |   . |. .|    ....|  ....                 ..||.|.. || |. | .| ||.   ...|.|  .
tvIvmltelve...lgrekcaqywpleegeslty...gdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielv

QKARRKH-LDRPVVVHCSDGVGRTGAFCTLFATLERVK---LEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYL
.|....   . ||.||||.||||.|.|....  |....    || .|.. . ..||.||||.|  |.||| .|||.| .|
rkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 13-301 6.6e-70 230.7 In-house 6-293 (439) alignment 
Range on Protein: 13-301
Range on HMM: 6-293/439.0
ELKQHYLRMHANSDLLFEKEYKDIKE---PVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDSEStDYINANWIDGFKQEKKYIATIGPKAETT
|...|  ... | . .|..... |.    . .. .    .  ...|||| .. |.||.||.|  . |   |  |||||.|.|. ..| |||| ||| |||
efqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphs.hyinanyikGyyddklyiatqgpkkett

SDFWRMMWEHKSSIVVMLTKLVEKGKvkchkYWPEENEQY-GEIIVTLEEKEELADFEIRKFFL-RKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEF
 ||||...|.|.. .||||.|||  |     ||| ..| . |.|.|  . . || .. || | .  .  .    | | .|....|||..||  |. .|.|
ddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldf

WKRVRNSWEGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLRM
 . .  . .  . ||. |||||||||||| | .|  .||.| || .|.   |. .| ||. |||   || ||. |.|| . .||. . ..... 
lrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefkk
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 9-288 1.4e-69 229.1 In-house 2-284 (290) alignment 
Range on Protein: 9-288
Range on HMM: 2-284/290.0
IPVAELKQHYLRMHANSDLLFEKEYKDIKEPVNVTTR-HCDNLINKPKNRYGNIKAYDHSRVILSSVQGDSE-STDYINANWIDGFKQEKKYIATIGPKA
||| .. ..    ||. .  |....| ..   .  |  .     ||..||. ||  ||  |..|  ..|. . . .|||| .|.|.|..|.|||| ||  
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

ETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEE-NEQYGEIIVTLEEKEELADFEIRKFFLRKLSNQMETRMVKHFYFTSWPDHD-VPEYATGL
.|  |||...|..|..|.||||. .|.|||||..|||.. ...|||. ..| . |.| .. .||. ... ... ....|... .|.|.... |....| |
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtil

LEFWKRVRNSWEGPqSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVT
| . ..... .     ..| ||||..|||...|....  ... | |   ||.. . . | |.  .||   || .|.. .|....
lvieemyktqrkrg.ntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld
0045450 (Phosphotyrosine protein) phosphatases II 308-572 1.8e-69 230.1 In-house 19-304 (307) alignment 
Range on Protein: 308-572
Range on HMM: 19-304/307.0
EKVAGTGMTGLEREFQLLNGAVPDELSDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDK-EDTTYINASYL--------EGYQEKVAFIATQAPLDN
 .   ...|||..||. |.   .. | ....|  |.| .||||..|||....||.|  .... ||. ||||||         .||  | .|||||.||..
llllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpe

TIEDFWRMVWHEEVFCIVMLCGLNEPlevFFSAIYTYLCWWgGGRW----------TLKKTNGVIVSEINFNP--KTGEVRQISHFMYLEWTEHAVPTKL
|.||||||.|.. | .||||..| |     .  .. |     |. .            .. .|..|  ..  .  .|||.|.. || |..| .| ||. .
tvedFwrmlweqgvtvivmltelvel...grekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsf

LTIIDLIGDLQKARRKH-LDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGV---LDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYL
 ...|.|  ..||....  . ||.||||.||||||.|....  |.... ||.   .|.. . ..|| ||||.|  ..||| .|||.| .|
eelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
0039614 (Phosphotyrosine protein) phosphatases II 308-574 3.2e-69 229.0 In-house 24-291 (297) alignment 
Range on Protein: 308-574
Range on HMM: 24-291/297.0
EKVAGTGMTGLEREFQLLNGAVPDelsdFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDK-EDTTYINASYLEGYQE-KVAFIATQAPLDNTIEDFWR
 .   ...|.|..||. |   .||    ...|  |.| .||||..|||....||.|  ...  .|..||||||..||   . .|||||.||..|.|||||
llekansktllllefeellslkpd....ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwr

MVWHEEVFCIVMLCGLNEPLE---VFFSAIYTylcWWGG---GRWTLKKTNGVIVSEINFNPkTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKA
|||.. | .||||. |.|       ...   .    .|.      . .. .|..| ...  . .||.|.. || |. | .| ||  | ......  ...|
mvweqgvtvivmLtklvelgrkcaqywpeegg...tygdftvtllkvehldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslellleflelvrea

RRKH-LDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYLDS
...   ..||.||||.||||||.|....  ||... || .||. . ..|| ||||.|  ..||| .|.|.| .|  
laelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
0043336 (Phosphotyrosine protein) phosphatases II 302-572 1.1e-68 227.1 In-house 6-277 (278) alignment 
Range on Protein: 302-572
Range on HMM: 6-277/278.0
RLMQLAEKVAGTGMTGLEREFQLLNGAVPdelSDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIE
.|... ...  .. |.|..||. |.   .    ....|  |.| .||||..|||....||.|  ..  .|..||||||..||. . .|||||.||..|.|
dllkallelllnlktllllefeellsfkl...dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetve

DFWRMVWHEEVFCIVMLCGLNEplevffSAIYTYLCWWGGGRWTLKK----------TNGVIVSEINFNP-KTGEVRQISHFMYLEWTEHAVPTKLLTII
|||||||.. | .||||..| |          ..  .| || .| ..           ....|  ..  . ..||.|.. |. || | .| ||. | ...
dFwrmvwelgvttivmLtelve......lgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslslll

DLIGDLQKARRkHLDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYL
|.. ....|.. . . ||.||||.||||||.|..|.  ||... || .|.. . ..||.||||.|  ..||| .|||.| ||
dflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 9-294 2.2e-68 225.3 In-house 2-285 (287) alignment 
Range on Protein: 9-294
Range on HMM: 2-285/287.0
IPVAELKQHYLRMHANSDLLFEKEYKDIKE----PVNVTTRHCDNliNKPKNRYGNIKAYDHSRVILSsvqgdSESTDYINANWIDGFKQEKKYIATIGP
||| .. .   . ||...  |.. .. ...    . .||     .  ||.|||. .|  .|  ||.|       |  ||||| .|||.|..|..|.. .|
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasq..nkdknRltqilvpdnyrvllk.....gehpdyinavfidgykekkafiiaesP

KAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEEN-EQYGEIIVTLEEKEELADFEIRKFFLRKLSNQMETRMVKHFYFTSWPDHD-VPEYAT
 ..|  .||....... ...|||... |. . .|..|||||.   .||  ..| ..|  |.. .||. ... ... ....|| . .|.|...  |.|..|
mfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqt

GLLEFWKRVRNSWEgPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEI
 || . .....    .  ..| ||||..|||...|. ..  ... |.|  .||.. . . | |.  .||  .|| ||  ..|| .. ..|  
illvieemyktqrk.rgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetys
DSPc_SM00195 318-572 1.3e-67 223.3 In-house 2-262 (263) alignment 
Range on Protein: 318-572
Range on HMM: 2-262/263.0
LEREFQLLNGAVPDElsDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVM
|..||. |. . ...  .. .| ..||..|||| ||||... || |. ...||...||||.|..|...| ..||||.||..|.||||||||.|.| .|||
lkeefekleestspk..etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

LCGLNEP----LEVFFSAI----YTYLCWWGGGRWTLKKTNGVIVSEINFNPKT-GEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKHlDRPV
|.  .|      . ..        |.       ... || . .|. ... . ..  | |.. .. | .|..| || .   ...|.  ..| ...  . |.
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpi

VVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYL
|||||.||||||.|.|.   |.... |  .|.| . ..||.||||||. |.||. .|||||.|.
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 318-572 1.3e-67 223.3 In-house 2-262 (263) alignment 
Range on Protein: 318-572
Range on HMM: 2-262/263.0
LEREFQLLNGAVPDElsDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVM
|..||. |. . ...  .. .| ..||..|||| ||||... || |. ...||...||||.|..|...| ..||||.||..|.||||||||.|.| .|||
lkeefekleestspk..etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

LCGLNEP----LEVFFSAI----YTYLCWWGGGRWTLKKTNGVIVSEINFNPKT-GEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKHlDRPV
|.  .|      . ..        |.       ... || . .|. ... . ..  | |.. .. | .|..| || .   ...|.  ..| ...  . |.
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpi

VVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYL
|||||.||||||.|.|.   |.... |  .|.| . ..||.||||||. |.||. .|||||.|.
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_CG7180_pd Subfamily CG7180 23-288 6.3e-67 220.3 In-house 13-291 (296) alignment 
Range on Protein: 23-288
Range on HMM: 13-291/296.0
ANSDLLFEKEYKDIKEPVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDSESTdYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSS
 .  .....|.| ...  . . ..  .. |. |||. ..  ||. ||.|....|...|  |||| ..|.| ..|.|| | .|| ||  .|||.......|
rkfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksd.YinavyvdsflkkkeyivteapkketvdefWrlvydeeis

IVVMLTKLVEKGKvKCHKYWPEE-NEQYGEIIVTLEEKEELADFEIRKFFLRKL---------SNQMETRMVKHFYFTSWPD-HDVPEYATGLLEFWKRV
 ||.|||  .  | ....|||.. .||||||.| . |....|...||.| | |            ..|||.||.| .| |.  . ||  ...|.|. .||
avvvLtktfdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrv

RNSW----EGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVT
|       | |. ||. |..| |..|.| .. ||| .|....|. .||. .| ..| .|. .|.   .| .|   ||||| 
rlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl
subfamily_PTPN13_pd Subfamily PTPN13 30-287 1.3e-66 219.7 In-house 14-269 (273) alignment 
Range on Protein: 30-287
Range on HMM: 14-269/273.0
EKEYKDIKEPV-NVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGdsestdYINANWIDGF--KQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVM
..|.|...|     |..   .  || |||| |.  ||..||.|..  |      ||||..|     |.| .|||. ||  ||..|||.|.|| |.....|
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg......yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviam

LTKLVEKGKVKCHKYWPEENEQ----YGEIIVTLEEKEELADFEIRKFFLRKLsNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEgpQSGP
.|. .||||||||.||||....    .. . |.|.. ..| .| .|.. .... .  |.| | |. |..||||.||  |. ||.| ..||.  .  ..||
vtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkds.esgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagP

ITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAV
| ||||||.||.||.|.||.... |. .. .||   | ..| ||. .||   || |.. |.||..
ivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 45-286 1.7e-66 219.0 In-house 13-263 (270) alignment 
Range on Protein: 45-286
Range on HMM: 13-263/270.0
RHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDSEsTDYINANWIDGFKQ-EKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWP
   .   .|  ||| .|    ..||.|.... ||. | |||||.. ||.. .|||||. ||.. |...||||.||.|.. .||.|.|.|||. || .|||
dlpeaargkklnRyadiLPsPatRvrleeleedsa.taYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWp

EENEQ-----YGEIIVTLEEKEELADFEIRKFflrKLSNQMETRMVKHFYFTSWPDHDVPEYAT------GLLEFWKRVRNSWEGPQS-GPITVHCSAGV
.|...     .|.| |. ...|    . ...    .| .. |.| . ||....|||| ||. .        ||.  . ||.| .  .  .|. |||||||
aepkekvkledgkikvlalseekeegyiltrl...rleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGv

GRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEA
|||||.|..| ... ..|.. .|| . ....| .|  .|| | || |.. |..| 
gRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavvey
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 6-325 4.7e-65 214.5 In-house 1-274 (392) alignment 
Range on Protein: 6-325
Range on HMM: 1-274/392.0
RQPIPVAELKQhYLRMHANSDlLFEKEYKDIKEPVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVqGDSESTDYINANWIDGFKQEKKYIATIGPK
|||||||..   ..     |  || .|..|. .|    .. . . ||..||||.||  || .||.|  .  |.  .||.|| .|..|..|| |||. ||.
rqpipvaqfpa.fveknrhsa.lffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvklevi.ddipdsdylnasyipsfdnekayiasqgpn

AETTSDFWRMMWEHKSSIVVMLTKLVEKGkvkchkywpeeneqygeiivtleekeeladfeirkfflrklsNQMETRMVKHFYFTSWPDHDVPEYATGLL
| . .|||||..... . ..|.||| |                                            .  ..| |  |.|| |||.|||.... ||
aaslddfwrmvfqenvttiamvtklkegd..........................................kgddartvaqfhftewPdkdvpkhtssll

EFWKRVRNSWeGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLRMRLMQ
.| | |.  . |  . |. .||||||||||  | ||... . |.  ..||. .|. || .| .|||   ||.||. |.|| . . .| | |  .  .| .
kfikevkadf.Gqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqd

LAEKVAGTGMTGLEREFQLL
|   . | . .   .||. |
lstssdGdvrskqlkefrsl
subfamily_PTPN1_pd Subfamily PTPN1 28-295 7.2e-65 213.6 In-house 7-281 (290) alignment 
Range on Protein: 28-295
Range on HMM: 7-281/290.0
LFEKEYKDIKEPV-NVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGdsestDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVM
|... |.||..   ...||....  |...||| ... |||||..| . .      |||||. ..  . ...|| | || ..|.. ||.|.||.||  |||
lykeiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn.....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvm

LTKLVEKGKVKCHKYWPEENE----QYG--EIIVTLEEKEELADFEIRKFFLRKLSNQmETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWE-GPQ
| |.|||...||..|||...|    ..   .. |.| ..|.   . .|.. | .|. | ||| . ||..|.|||  |||  . .|.|  .||.|    ..
lnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktq.etreilhfhyttwpdfgvpespaaflkflfkvresGslssd

SGPITVHCSAGVGRTGTFIVIDAMMEQI---KEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTF--GDTEIE
 ||  .|||||.||.|||...|... .|   .. . .|.   .  .| .|  ..| . |  | . |.|| . .  ||. ..
vGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdssvq
0040439 (Phosphotyrosine protein) phosphatases II 335-572 3.2e-62 205.7 In-house 2-246 (249) alignment 
Range on Protein: 335-572
Range on HMM: 2-246/249.0
DFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEPlevffSAIYT
....|  |.| .|||||.|||....||.|  .|. ... ||||||..||. | .|||||.||..|.||||||.|.. . .||||. | |.       .  
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvel.....grekc

YLCWWGGGRWT----------LKKTNGVIVSEINFNP-KTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKH-LDRPVVVHCSDGVGRTGAF
.  |  || ..           .. ....| ..   . ..||.|.. |. |. | .| ||  . ...|.|  ..||...   . ||.||||.||||||.|
aqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtf

CTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYL
....  ||... |. .|.. . ..||.||||.|  ..||| .|||.| .|
iaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 339-577 8.4e-62 203.6 In-house 4-247 (250) alignment 
Range on Protein: 339-577
Range on HMM: 4-247/250.0
ATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEPLEVfFSAIYT--YL
| .|.| .|||| .|.. . .||||      ... |||||.|.||.|. ||||||.|| .|||||||||..|..  ||||  |.|  .. ..  .     
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPveka

CWWGGGRWTLKKTN---GVIVSEINFNPK-TGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKHLDRPVVVHCSDGVGRTGAFCTLFATLERV
  .|. . .|....    ... ..    .   . |.. .. .. | . .|| .  ....|. ..|. ...  ..||.|.|| ||||.|||... | |||.
ekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerl

KLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYLDSFEE
| | |.|||   ..||..||..|  |.||  .||.|| .|||.|.
kkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsved
Y_phosphatase Protein-tyrosine phosphatase 344-569 9e-62 203.9 Pfam-A 1-234 (235) alignment 
Range on Protein: 344-569
Range on HMM: 1-234/235.0
NSKKNRYPNILPCERCRVVLPAIPDKEDttYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEP----LEVFFSAIYTYLCWW
|.|||||..|||... || |   ....|  ||||.|..||.|| .|||||.||..||||||||||.|.| .||||. |.|     .. ...      .  
nkkknRykdilpydktrvklkgsegpsd..YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GGGRWTLK-K----TNGVIVSEINFNPKTGE--VRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARrKHLDRPVVVHCSDGVGRTGAFCTLFATLERV
|  . .|| |    .......... . |..|   |..... | .|..| ||..   ..||| ...| . .. . |||||||.|||||| |..| . ||..
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

KLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAIL
. |. .||. . ..||.||||||. |.||  .|.|||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 344-569 9e-62 203.9 In-house 1-234 (235) alignment 
Range on Protein: 344-569
Range on HMM: 1-234/235.0
NSKKNRYPNILPCERCRVVLPAIPDKEDttYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEP----LEVFFSAIYTYLCWW
|.|||||..|||... || |   ....|  ||||.|..||.|| .|||||.||..||||||||||.|.| .||||. |.|     .. ...      .  
nkkknRykdilpydktrvklkgsegpsd..YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GGGRWTLK-K----TNGVIVSEINFNPKTGE--VRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARrKHLDRPVVVHCSDGVGRTGAFCTLFATLERV
|  . .|| |    .......... . |..|   |..... | .|..| ||..   ..||| ...| . .. . |||||||.|||||| |..| . ||..
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

KLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAIL
. |. .||. . ..||.||||||. |.||  .|.|||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_PTPRA_pd Subfamily PTPRA 336-571 6.5e-61 201.0 In-house 50-294 (330) alignment 
Range on Protein: 336-571
Range on HMM: 50-294/330.0
FYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEPLEVFFSAIYTY
. .|.. .| .|||..|||| .  ||.|. .  .|.. |||||...||.||  |||.| |...|.||||||.|  .   ||||  |.|  |      .  
lelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPd

LCWWGGGRWTLKKTNGVIVS----------EINFNPKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKHLDrPVVVHCSDGVGRTGAFCTL
   .  |  ...  . ...           ... . .  ..|... | .  | .  ||..   ...|.  ..| .... . |.||||| ||||||.|..|
eGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivl

FATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAY
 | ||||| |...||| . . ||.||| ||  . || ..|...| |
davlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 315-576 7.8e-61 200.9 In-house 21-287 (305) alignment 
Range on Protein: 315-576
Range on HMM: 21-287/305.0
MTGLEREFQLLNGAvpDElsDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFC
 .||| ....|     .|   .   .. .| .|||. .| . .  |. | . ....|. ||||||..||..| ..|..|.||.||..||||....| |  
dkgleaqykslyee..ee..sidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvst

IVMLC----GLNEPLEVFFSAIYTYLCWWGGGRWTLKK---TNGVIVSEINFNP--KTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKHLD
||||.    | ..  . ..    |.   .|    .||    ... |  ...     .  | |.....   .| .| ||..  ....|| ..||...|  .
ivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkg

RPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYLDSFE
 |..||||.||||||.|...   |||.| |.|.|||   . ||..|..||. ||||  ...|.  .. ...
vpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgd
subfamily_PTPN23_pd Subfamily PTPN23 25-287 1.3e-60 199.7 In-house 13-280 (288) alignment 
Range on Protein: 25-287
Range on HMM: 13-280/288.0
SDLLFEKEYKDIKEPVNVTTRHCDNLI---NKPKNRYGNIKAYDHSRVILSsvqgdSESTDYINANWIDGFKQE-KKYIATIGPKAETTSDFWRMMWEHK
    ..|..|....  .  .|.    |   .  |||. .|  |||.|| |      ..  ||||| .. .      ..||| .|...| .|||.|..| |
gktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr.....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqk

SSIVVMLTKLVEKGKVKCHKYWPEENE---QYGEIIVTLEEKEELADFEIRKFFLRKLsNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRN---S
||..|||..  |.|| |...||||...   ..|.. |||....|.  .  |.. |. | .. ....|.|  .||||.. ||.    ||.| . |..   .
ssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletl.dadavksvshlqltsWpelGvPasPetllqfldevesayea

WEGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEEN-LLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAV
 . .   |. |||||||||||.| .. | .......| |||.   |||.|.|| ||||  .|. |   | |||.
vqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa
0042113 (Phosphotyrosine protein) phosphatases II 338-572 1.4e-60 200.1 In-house 3-243 (245) alignment 
Range on Protein: 338-572
Range on HMM: 3-243/245.0
TATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEplevfFSAIYTYLC
.|  |.| .||||..|||....||.|. ..  .|..||||||  ||. .  |||||.||..|.||||||.|.. . .||||. . |     .. .  .  
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeee.....lgrvkcaqy

WWGGGRWTL----------KKTNGVIVSEINFNP-KTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKHLDRPVVVHCSDGVGRTGAFCTLF
|  |. .|           .. ....| ...  . ...|.|.. |..|| | .| ||. | ...|..  ..||.... . ||.||||.||||||.|....
wplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaay

ATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYL
  ||... |. .... . ..|| ||||.|  ..||| .|||.| .|
lmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 28-299 1.6e-60 199.4 In-house 10-278 (283) alignment 
Range on Protein: 28-299
Range on HMM: 10-278/283.0
LFEKEYKDIKEPVNVTTRHCdNLINKPKNRYGNIKAYDHSRVILssvqgDSESTDYINANWID---GFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIV
|| . .| .  |   .. .. .  ||.|||. .| ..|  || |     .||| ||||| .|      ||.||||.. .|  .|  |||.|....| . .
lfrevlkrlsvpdldadias.adenkrknrnqeivpadqwrvel.....ksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitai

VMLTKLVEKGKVKCHKYWPEE-NEQYGEIIVTLEEKEELADFEIRKFFLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGPqSGPI
|||||| |  ..|| .|||..  |.|||  |||..      | |... ||. |   .| .. |. .  | . .       |. | | . .  | .  |||
vmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqtesk.kgPi

TVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNL
 ||||.|.|||..|| . | ..... | ..||.. |  .| ||  .||   || ..| . ||    |||.|   .|
vvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdl
0045098 (Phosphotyrosine protein) phosphatases II 330-572 1.8e-58 193.4 In-house 22-272 (278) alignment 
Range on Protein: 330-572
Range on HMM: 22-272/278.0
PdelSDFYTATQPKNSKKNRYPNILPCERCRVVlpaipdkeDttYINASYLEGYqeKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEPLE---
|   |....|  ..| .||||..|||....||.        |  ||||||..||  . .|||||.||..|..|||||.|.. . .||||..| |      
p...seitpalylgnldknRykdilpydhsrVk........d..YINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekc

----------------VFFSAIYTYlcwwgggrwTLKKTNGVIVSEINFNPKTGEVRQISHFMYLEWTEHAVPTKL--LTIIDLIGDLQKARR-------
                | .  ....             .   .|  ........| | . |. || | .| ||.      ...|.  ...|..       
aqywpeggsltygdftvtllseevl.........ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslll

-----KHLDRPVVVHCSDGVGRTGAFCTLFATLERVklEGVLDVFITARMLRTQRPG-MVSHLDQYRLCYEAILAYL
        . ||.|||| ||||||... ..  ||..  ||..|.. . ..||.|||| .| .|.||| .||..| .|
sslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 30-284 2.2e-58 192.3 In-house 17-274 (287) alignment 
Range on Protein: 30-284
Range on HMM: 17-274/287.0
EKEYKDIkEPVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSvQGdSESTDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTK
..  .|  | . .| .  ..| .  ||||...  .|..||.||  .|    .||||||.. ........||. || | |  ||||...|..|. |...|.
dalkeds.esstatfkaaeelaavkknryadvlPiddtrvllsa.eg.elGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtr

LVEKGKVKCHKYWPEENEQ---YGEIIVTLEEKEELADFEIRKFFLRKLSNqMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRV----RNSWEGPQSGP
 ||... ||.||||| .      |  .| |. .    .. .| . | .|    |.|.|| . . ||||. ..  | ||. |   |      . .. . ||
eveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidlet.rearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGP

ITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALL
. ||...|.||.|... . ..... ..   .||   | |.| .|. .|| . |. ..  || 
lvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_PTPRN_pd Subfamily PTPRN 19-287 3.3e-58 191.7 In-house 21-292 (297) alignment 
Range on Protein: 19-287
Range on HMM: 21-292/297.0
LRMHANSDLLFEKEYKDIKEPVN--VTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGdSESTDYINANWI-DGFKQEKKYIATIGPKAETTSDFWRM
|. | .    .|||.. ...  .   |.  ...  |  |||. .. .|||||| |.. .  .|..|||||  | |   ..  |||| || |.| .|||.|
ledhlknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeas.aeksdyinasaildhdprapayiatqgplastvadfwqm

MWEHKSSIVVMLTKLVEKGKVKCHKYWPEENE-QYGEIIVTL-EEKEELADFEIRKFFLRKLSNQmETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRN
.||. . ..|.||.| |.|  .|..|||.| .  |.   | |  |.    |. .| |.|. | .. ||| |  |.| |||...||  |  |||| ..|  
vweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqts.etrtvtqfhflswpeegvPasaksllefrrkvnk

SWEGpQSGPITVHCSAGVGRTGTFIVIDAMMEQI-KEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAV
|. | .| || ||||.|.||||..|.|| ..... |  . .|. . .  .| ||. .|.  .|. |.  |. | |
syrG.rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 312-577 1.3e-57 189.9 In-house 16-288 (290) alignment 
Range on Protein: 312-577
Range on HMM: 16-288/290.0
GTGMTGLEREFQLLNGAVPDelSDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKED--TTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWH
 .|..| . .|. |. .  .     .... ..|...||. ||.. .  |..|  |....|    ||||.|..||.|| ..||||.|. ||. |||...|.
akgnegfrnqfkmldsgese..htvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwq

EEVFCIVMLCGLNEPLEVFFSAIYTYLCW--WGGGRWTL---KKTNGVIVSEINFNPKT--GEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRK
|.| .||||.  .|  .|     ..      .|  . .|   ...|. |  ... . |.  |. ... ..    | ..   |.  ||. .|   .| .||
ekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrk

HLDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYLDSFEE
. ....||||||.|||.. ||..  |....| ||| |||   . .|.|.||.|   .||.. .. .| |||||| 
rgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfet
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 305-572 1.4e-57 190.0 In-house 10-279 (288) alignment 
Range on Protein: 305-572
Range on HMM: 10-279/288.0
QLAEKVAGTGMTGLEREFQLLnGAVpDELSDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFW
. . |   .. ||...|.. |  |. .. ..  .. ...| |||||.|||| .  || |   ...... ||||||..|...| ..||||.|| .|..|||
akvakksarnrtgfseeynsL.aal.ektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfW

RMVWHEEVFCIVMLCGL----NEPLEVFFSAIYTYlCWWGGGRWTLK---KTNGVIVSEINFNpKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQ
..|. ...  |||| .|    ..  | .. .  .    .|    ||.   ... ... ..  . |... ..| .. || |..| ||     ...|.  ..
elvyenktstivmltelveggktkCeeYWPdadkp.knyGsvtvtlveskeledfvlrkllle.kkkteleitqyqylaWpdhgvPeskapllellrqvk

KARRKHlDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYL
 |  .    |..||||.|||||| | .| | ...|. | ..||. |   || ||. .|  | ||  .||..|   
vanqad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 305-577 3.3e-56 185.4 In-house 9-283 (287) alignment 
Range on Protein: 305-577
Range on HMM: 9-283/287.0
QLAEKVAGTGMTGLEREFQLLNGaVPDELSDFYTATQPKNSKKNRYPNILPCERCRVVLPaipdKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFW
....|   .| .| .  |..|.  | ..  .   .  ..| .|||. .||. .  ||.|     .|.  ||||....||.|| |||....|. ||. .||
efvakghakgnegfknqftvleq.vtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfW

RMVWHEEVFCIVMLCGLNEPLEvffSAIYTYLCWWG---GGRWTLK-----KTNGVIVSEIN--FNPKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIG
.......|  ||||| ..|  |   .. | |         | ....     ...|.|. ...   . |.|. .|.  . . .| ..   |.  ||. .| 
kliddrnvtaivmlcqekende...evcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvie

DLQKARRKHLDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYLDSFEE
.  |..||. . ..||||||.|||.. ||    |....| |||.|||   .  | |.||.|   .||.  ....|.|||||| 
emyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfet
subfamily_PTPN14_pd Subfamily PTPN14 18-285 6.1e-56 184.6 In-house 15-294 (300) alignment 
Range on Protein: 18-285
Range on HMM: 15-294/300.0
YLRMHANSDLLFeKEYKDIK-EPVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDseSTDYINANWIDGF--KQEKKYIATIGPKAETTSDFWR
 | .. ..  .| .||  |. .  . ..  . .  |..|||. ..  |...|| ||. . .  ||.||||  |      .|..||.. ||   |  |||.
ilekkleegkvf.teyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken..stgyinassikvsvggkersyivaqgPleltvqdfWq

MMWEHKSSIVVMLTKLVEKGKVKCHKYWPEE-----NEQYGEIIVTLEEKEELADFEIRKFFLRKLSNQmETRMVKHFYFTSWPDHDVPEYATGLLEFWK
|.||.. ...||||.  |.|| |..||.|..     . ..|.  || . .|.   .  ... |. |  . | | | |. .| ||||.|||  .| |.. .
mvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpsk.eertvwhlqytDWpdhgvPeDvkgflsyLe

RV---RNSWEGP-----QSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLE
.|   |.  .       .. |. |||||||||||  |. | ... .. .. .|. . ..|.| || ..||  .|| |.. .|..
evqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlik
subfamily_PTPRB_pd Subfamily PTPRB 335-577 3.3e-55 182.2 In-house 42-290 (293) alignment 
Range on Protein: 335-577
Range on HMM: 42-290/293.0
DFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEPLEVFFSAIYT
   .|....|..|||| |||| .  || | |. |.... ||||.|..||. .  ||||| || .|..||||||| ...  ||||  | |   |     . 
avkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWP

---YLCWWGGGRWTLK---KTNGVIVSEINFNPkTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKAR-RKHLDRPVVVHCSDGVGRTGAFCTLFA
     . .|  . ||.   ...  .. |.. .  . | |.. .. .. |..| || |  |..|..  ...|  ... .||.||||| ||||||.| .|  
adeepvlyGdikvtlvaeeeledwvirelkiek.ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdr

TLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYLDSFEE
 |.... | ..|.| .   ||..|  .|   .||   ....|..| . ||
llqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkkee
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 13-292 5.6e-55 181.2 In-house 4-298 (301) alignment 
Range on Protein: 13-292
Range on HMM: 4-298/301.0
ELKQHYLRMHANSdllFEKEYKDIKEPVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQG-DSESTDYINANWIDGFKQEKKYIATIGPKAETTSD
.|..|   .|.|.   ||..||..||  . ..    .  ||. ||. ||. ||. |.||.  .  |. ...||||..|||....||.||. ||  .|  |
dlgthvaakhsnk...feeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvd

FWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPE---ENEQYGEIIVTLEEKEELADFEIRKFF------------LRKLSN--QMETRMVKHFYFTSWPD
|||..|..| . .||.|.| |. | ||..|||.   |.|..|.. ||| ..  . || ||..              ||.    ..... |  .  |.||.
fWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpq

HDV-PEYATGLLEFWKRVRNSWEgPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDT
. | .|..| |    . .   .  .  ||. ||||..|.|.|... ..  .|| | |   ||.  . ..| ..  .|.   ||..|. .. . ... .|
dGvvreprtvLqviddvihrqqk.igggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnst
0041856 (Phosphotyrosine protein) phosphatases II 52-294 6.1e-55 180.9 In-house 1-178 (182) alignment 
Range on Protein: 52-294
Range on HMM: 1-178/182.0
NKPKNRYGNIKAYDHSRvilssvqgdseSTDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTklvekgkvkCHKYWPeeneqyge
|..|||| .|  |||||             ||||||...|    ...||| ||  .|. ||.||..|.. ...|.||         .. |||        
nldknrysdilpydhsr...........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp........

iivtleekeeladfeirkfflrklsnQMETRMVKHFYFTSWPDHDVPEyATGLLEFWKRVRNswegpQSGPITVHCSAGVGRTGTFIVIDAMMEQikeeN
                          . ..|.. ......||||.||.    ||.| ..|..     ..||. ||||||||||||..... |...    .
..........................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g

lLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEI
 ..... |. .| .|. ||..|.|| |...|||| . ...|..
.vsleeavklvrsrRpgmvitpnqyfflqlallellllkktrp
subfamily_PTPN12_pd Subfamily PTPN12 338-573 1.2e-54 180.1 In-house 34-278 (290) alignment 
Range on Protein: 338-573
Range on HMM: 34-278/290.0
TATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEP----LEVFFSAIY
......| ||||| .||| .  ||.|  | ..|.  ||||....| ..|...||.|.|| .|..|||||.|. .|  .||.| . |      | ...   
agekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeeg

TYLCWWGGGRWTLKK----TNGVIVSEINFNPKtGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRkHLDRPVVVHCSDGVGRTGAFCTLFATL
   . .|  . ||..    ... ..  .. . . .| |..  | | .| .| ||..  ....|| .... .. . | |.||||| ||||||. ...  . 
eeelefgefevtleeekavdddflirtLkveaq.kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvr

ERVKLEGV---LDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYLD
| .| | .   ||||   . ||.||. .|   .||.| |.|.. .. 
ellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 289-570 5.3e-54 178.7 In-house 6-289 (319) alignment 
Range on Protein: 289-570
Range on HMM: 6-289/319.0
FGDTEIEVQNLRMRLMQLAEKV-AGTGMTGLEREFQLLNgAVPDELSDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKV
||.... |.....  .||. |  .   .| || ||. .   .. .|.|   |  ..|  |||. |||. .. .| |  .  .| . |||||...||| | 
fgesdvavpdfpayyqqlsnksdfdddltklevefrrac.klgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkd

AFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCglNEPLEVFFSAIYTYL-CWWGGGRWTLKKTNGVIVSEINFNP--KTGEVRQISHFMYLEWTEHAVPT
 .||.| |||||..|||||.|  ..  ||.|   ..    ..                ....|.  .| .|.     |  ..|.|  | .| | .. || 
kyiaaqGPldntladfWrmiweyncstivllt..kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpd

KLLTIIDLIGDLQKARRKH-LDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILA
    .. |.  ... ..|    ...||||| ||||||.. .| . |.|.| |  .||. . | || ||. .| .| || ..| |.| 
ypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 342-573 2.6e-53 175.9 In-house 26-269 (274) alignment 
Range on Protein: 342-573
Range on HMM: 26-269/274.0
PKNSKKNRYPNILPCERCRVVL-PAIPDKEDTTYINASYLEGYQEK-VAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEPLE----VFFSAIYTY
.....|||| .||| |. ||.| .. ...||..|||| |. ||.|.  |..||| || ||..|||||...|||  ||||  |.|  |    |.|     |
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

--LCWWGGGRWT---LKKTNGVIVSEINFNPKTGeVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKHLDR--PVVVHCSDGVGRTGAFCTLFAT
     .|.   .    ...|.  | ..  .  .   |.. |..| .| .| .| .  |..||. . ...|...  .  ||||||| |.||||.| .   .
eiserygdveikvekiverndysvrklvlkyler.ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisia

LERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYLD
. ... |.|.||. .   || .| |||   .||.| ..|.  || 
vrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
0051429 (Phosphotyrosine protein) phosphatases II 81-289 3.3e-53 176.3 In-house 4-226 (272) alignment 
Range on Protein: 81-289
Range on HMM: 4-226/272.0
TDYINANWIDGFKQ---EKKYIATIGPKAETTSDFWRMmWEHKSSIVVMLTKLVEKGKVKCHKYWP-------------EENEQYGEIIVTLEEKEELAD
..||||....|. .   ....... ||   |  ||||. .|.. . .|.|....|.|..||..|||             ..   || . ||| ..| | |
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

FEIRKFFLRKLSNQMETRMVKHFYFTSWPDHDVPEYAtgLLEFWKRVRNswegpqSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLD--------VY
. .|.. |..|..  |.|.| |...|.|||| ||. |  |||. . ...      .||. ||||||..||||..... ..... .|  .|        ..
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyle

SYVSRIRAQRNFMVQRPSQYSFIHYALLEAvTF
 .|...||||  .|| . || |.. ||||.   
eaveelraqrpgavqteeqylflyeallel.lr
0037934 (Phosphotyrosine protein) phosphatases II 336-571 6.1e-53 175.2 In-house 2-241 (243) alignment 
Range on Protein: 336-571
Range on HMM: 2-241/243.0
FYTATQPKNSKKNRYPNILPCERCRVVLpaipdkEDTTYINASYLEGYqEKvaFIATQAPLDNTIED----FWRMVWHEEVFCIVMLCGLNEPlevffsA
|..|  | | .||||..|||... ||.|      |.. ||||.. ... ..  .||||.||..|.||    ||||.|.. . .||||. | |        
fsiallpenlsknrysdilpydhsrvkl......egsdyinanliyvt.pr..liatqgPlpetveddlasfwrmlwelgitvivmltelvEl......g

IYTYLCWWGgGRWtlkKTNGVIVSEINFN--------------P-KTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRK-------HLDRPVV
 . .   |  | .     ....|  ....              .  ....|.. |..|| | .| ||.    ..|.. ....  ..       . ..||.
rekcaqywp.gev...tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvl

VHCSDGVGRTGAFCTLFATLERVkleGvLDVFITARMLRTQRPG-MVSHLDQYRLCYEAILAY
|||| ||||||......  |...   | .|.. . ..||.|||| .|  ..||| .|||.| .
VHCsaGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 332-570 8.3e-52 171.4 In-house 13-253 (284) alignment 
Range on Protein: 332-570
Range on HMM: 13-253/284.0
ELSDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCglNEPLEVFFSA
...|   |  ..|  |||. .||. .. .| |  .  .| . |||||...||| |  .|||| |||||..|||||.|  ..  ||.|   ..    ..  
ngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt..kdkcsqywpl

IYTY-LCWWGGGRWTLKKTNGVIVSEINFNP--KTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKH-LDRPVVVHCSDGVGRTGAFCTLFA
              ......  .| .|.     |  ..|.|  | .| | .. ||     .. |.  ... ..|.   ...||||| ||||||.. .| .
kivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldv

TLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILA
 |.|.| |  .||. . | || ||. .| .| || ..| |.| 
lldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
0036282 (Phosphotyrosine protein) phosphatases II 81-281 6.2e-51 167.8 In-house 2-164 (174) alignment 
Range on Protein: 81-281
Range on HMM: 2-164/174.0
TDYINANWIDGFKQEKKYIATIGPKAettsdFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEeneqygeiivtleekeeladfeirkfflrklSNQME
.|||||...|..   ...||. || |     ||.|..|.....||||....|.|..||. ||||                                 . .
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lredl

TRMVKHFYFTSWPDHDVPEYATgLLEFWKRVRNSWEGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKeENLLDVYSYVSRIRAQRNFMVQRPSQYSFIH
.|.. ..... |||| ||. .. |||| |.|..  . ...||. ||||||||||||..... |. ... |.| |....| ..| ||  |||.|||| |..
erlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly

Y
|
y
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 308-572 2.5e-50 166.5 In-house 15-288 (325) alignment 
Range on Protein: 308-572
Range on HMM: 15-288/325.0
EKVAGTGMTGLEREFQLLNgavPDELSDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMV
||       |. .||.||    .|.   . .|..|.| .|||..|... .. |||| .  |. .. |||||||. ...|  |.|.|||| .||.|.||.|
ekkkaqdqdgfahefgllp...sddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlv

--WHEEVfcIVMLCGLN---EPLEVFFSAIYTYLCWWGGGRWTLKKTNGV---IVSEINF-NPKTGEVRQISHFMYLEWT---EHAVPTKLLTIIDLIGD
  |.  |  .|.|  |.   .   |..         .|| .  |.  . .   .   ..  ..| || | .  | .  |     .  |. |..|..|.  
ldWrcsv..vvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvka

LQKARRK--HLDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYL
...  .   .   |..||||.||||||.| .|.. |..|  |  .|.|   . || .|| ||   ||| |.|||.  ..
vservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 316-571 1.8e-49 163.4 In-house 24-278 (315) alignment 
Range on Protein: 316-571
Range on HMM: 24-278/315.0
TGLEREFQLLNGAvpdELSDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCI
 |...... . |    .|  . .| . .| .|||| ||.. .. || || .  .... |.||....||. |  .||.|.|. ....||||.|..|..  |
ngfkqdyesipgg...qlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigki

VMLCGLNEPLEVFFSAiYTYLCWWGGGRWTLKKTNGVIVSEINFN----PKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKHLdRPVVVH
||| .| |  .      |        |. |. . .  . .|.           ..|..  . |  | .  ||   .....||   .. . .    ..|||
vmltnlvegekrkaek.ywpdkkviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvh

CSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAY
||.||||||.|.|| | |.... | ..||.   . .| .| .||. ..||.. |.|.|  
csaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydallet
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 335-577 4.2e-49 162.3 In-house 39-289 (297) alignment 
Range on Protein: 335-577
Range on HMM: 39-289/297.0
DFYTATQPKNS---KKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEkvAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEPLEV----
  ...|. ..    .|.|| |||| .. || |  . |. |  |.|||...|...   .|.|| | ..|..|||.||..|.|  ||||  .||  .     
niqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcary

FFSAIYTYLCWWGGGRWTLKKTNGVIVSEINFNPKTGE-VRQISHFMYLEWTEHAVPT--KLLTIIDLIGDLQKARRKHLDRPVVVHCSDGVGRTGAFCT
..    | .        .... .| |  |.. .       | .  . ..|| ..||.   .  ....|| ...|   .. . |..|||. |||||| ..|
WsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvllt

LFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYLDSFEE
.   . ..| |  .|.| . ..|| .|| .|   .||.. |.|.| .| | . 
idsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedt
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 337-573 5.4e-49 161.7 In-house 37-278 (315) alignment 
Range on Protein: 337-573
Range on HMM: 37-278/315.0
YTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEPLEV----FFSAI
 .| .. | ||||| |||| .. ||.|  | |. |  ||||||......  |.||.|.||. ...||||||..|.|  |||.  ..|   .    ..   
rvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdr

YTYLCWWGGGRWTLKK---TNGVIVSEInFNPKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLqKARRKHLDRPVVVHCSDGVGRTGAFCTLFATL
 . .  .|  . .| .   . . .. ..    |. | |... | . || .. |. .. ... || .. || ... . ...|||| |||||| ....   .
kadsvefGsikvellsleadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqtssllklikev.kadngkkefsllvhcsaGvGrtGvvisidevv

ERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYLD
...| . ..||| . ..||..|| .|   ..| . |.|.| .| 
aqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_PTPN23_pd Subfamily PTPN23 312-573 1.3e-48 160.3 In-house 11-281 (288) alignment 
Range on Protein: 312-573
Range on HMM: 11-281/288.0
GTGMTGLEREFQLLNGAVPDELSDFYTATQPKNSKKNRYPNILPCERCRVVLPaipdKEDTTYINASYLEGYQEKV-AFIATQAPLDNTIEDFWRMVWHE
  | |.|...|..|. .   |  .. .|   ..|.|||. .||| .. ||.|     ..   |||||....       ||||||||..|. |||.||...
ldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeq

EVFCIVMLCGLNEPLEV----FFSAIYTYLCWWGGGRWTLKK---TNGVIVSEINFNP-KTGEVRQISHFMYLEWTEHAVPT---KLLTIIDLIGDLQKA
 .  ||||   .|  .     .. .       .|  . |||.   |. ..  ... .  .. .|...||  . .|.|. ||    .|| ..| . .  .|
kssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayea

RRKHLDRPVVVHCSDGVGRTGAFCTLFATLERVK-LEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYLD
...... |.||||| ||||||.|. ..| .. ..  .|.||.    . ||.||  ||.. .|.. .|||.| .  
vqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaar
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 39-285 1.6e-47 157.0 In-house 30-275 (307) alignment 
Range on Protein: 39-285
Range on HMM: 30-275/307.0
PVNVTTRHCDnlINKPKNRYGNIKAYDHSRVILSSvqgDSESTDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKC
|  ||.   .   |  |||| ..|. |..|...     |  ..||| ||..    . ||.|.. ||. .|  .|| |. ..|   |.|| |..| .|.||
pegvtveafs..antdknryqdvkcqdkgrivvkf...dglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikc

HKYWPEENEQ---YGEI-----IVTLEEKEELADFEIRKFFLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNswegpQSGPITVHCSAG
..||| |. |   .||      .  |  |.   | .. .    |.    ..| ..|. .. |||. ||.   . ... . ||      .  |. ||||||
eqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry.....dtnpvvvhcsaG

VGRTGTFIVIDAMMEQ-IKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLE
|||.|| . |  .... |. .|  |.   |  .|.||.. .|   || ..|  |||
vGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlle
0049772 (Phosphotyrosine protein) phosphatases II 21-295 2.2e-47 157.7 In-house 15-288 (314) alignment 
Range on Protein: 21-295
Range on HMM: 15-288/314.0
MHANSDLLFEKEYKDIKEPVNVTTRHCDNLINKPKNRYGNIKAYDhSRVILSSVQGDSesTDYINANWIDGFkqeKKYIATIGPKAETTSDF--------
.    .||..  . ..  ... |.  .| . |. |||| .|  .| .||||... ...  .|||||...|||   .|.||| ||. .|  ||        
hddllklllvlnrrslsvlpeltilvadlflnrdknryldilpad.nrvilpglpvsg..sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyy

--WRMM--WEHKSSIVVM---------------------LTKLVEKGkvkchkywPEENEQYGEIIVtlEEKEELADFeirkfflrklsnqmeTRMVKHF
  |||.  ..... ..||                     |..| ..|        .| .... | .   ||  .  .|               .|.. ..
ngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng........neptaadlellk..eelydpelf...............erlgiky

YFTSWPDHDVPeYATGLLEFWKRVRNSwegPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEeNLLDVYSYVSRIRAqRN---FMVQRPSQYSFIHYALL
. . .||...|     ..|| . ...    .. ||. |||.||.||||||.|.. .| . .  .| .....| ..|   |    ... . || ||..|||
lripvpDgsap.lledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRp.inpnpgfieqleqyefileall

EAVTFGDTEIE
|.. |  ...|
eylkflkkfye
0043147 (Phosphotyrosine protein) phosphatases II 79-281 1.8e-46 153.3 In-house 3-155 (172) alignment 
Range on Protein: 79-281
Range on HMM: 3-155/172.0
ESTDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLvekgkvkchkywpeeneqygeiivtleekeeladfeirkfflrKLSNQ
|..|||||...|.    ...||| ||  .|..|||||..|.. ...|.||.|                                            .  .
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

METRMVKHFYFTSWPDHDVPeYATGLLEFWKRVRNSWEGPQSGPITVHCSAGVGRTGTFIVIDAMMeqikeeN-LlDVYSYVSRIRAQRNFMVQRPSQYS
 ..|.. ......||||.||  .  |||| . ...     ..||. ||||||||||||..... |.        | ...  |. .|..|. .|| |||| 
llerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqyr

FIHY
|..|
flyy
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 341-572 3.1e-46 152.5 In-house 40-276 (515) alignment 
Range on Protein: 341-572
Range on HMM: 40-276/515.0
QPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEPLEV----FFSAIYTYL
.  | ||||| |||| .. || |  | |. .  |.||||.....   |.||.|.|.. ...||||.|..|.|  |.|.  |.|   .    ..  . .  
eeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgds

CWWGGGRWT---LKKTNGVIVSEINFNpKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLqKARRKHLDRPVVVHCSDGVGRTGAFCTLFATLERVK
  .|  .     |.   | |  ...   |  ..| .  | . || .. || .  ... || .. || . ..  |...||| |||||| ....   . ..|
vkfGsikvelvsleactggikrkltvl.kgddsrtvtqfhfteWPdkGvpkhtssllklikev.kadhgqythpliihcsaGvGrtGvvisidsvvahak

LEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYL
   ..||| . . .| .|| .|   .|| . |.|.| .|
ttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 52-285 5.2e-46 151.6 In-house 56-281 (290) alignment 
Range on Protein: 52-285
Range on HMM: 56-281/290.0
NKPKNRYGNIKAYDHSRVILSsvqgDSESTDYINANWIDGFKQekKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEENEQ---
.  |||| ..   | .||||.    |    ||. ||...| |    .| | |. ..|. |.|||. ..| . .||| .|.|.|| ||..|.||.. .   
efkknrykdvvcndktrvilk....dGydGdyvhanyvkGlka..mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevlt

YGEIIVTLEEKEELADFEIRKFFLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSwegpqSGPITVHCSAGVGRTGTFIVIDAMMEQIK
.||| |.  |...  .  |.| .  .  ..    ..||.   ||||. |.  .  ||   . .|.      |||..||||||.||||||. |.. .. . 
fGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka.....sGpvvvhcsaGiGrtGtfvaievglqill

EENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLE
.   ||.   |  .|  |   ||   ||  .  .||.
dGkeldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 327-569 5.7e-46 151.7 In-house 18-263 (283) alignment 
Range on Protein: 327-569
Range on HMM: 18-263/283.0
GAVPDELSDFYTATqpKNSKKNRYPNILPCERCRVVLPAIPDkedtTYINASYLE---GYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNE
 .|||  .|  .|   .| .|||. .|.| .. || | . .     .||||...     |...  .|..|.|||.|. |||.||..|.. .||||  | |
lsvpdldadiasad..enkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqe

PLEVFFSAIYTYLCWWGGGRWT--LKK---TNGVIVSEINFNPK--TGEVRQISHFMYLEWTEHAVPTKLLTIIDLiGDLQKARRKHLDRPVVVHCSDGV
 |..  |  .        | .|  |.|    |  |. |.  . .  . .   ..|. . .|.|    . . ... .   ..  .... . |.||||| |.
dlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkf.nkvislqteskkgPivvhCstgi

GRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAIL
|||..|... |... .. | |.||| . ...| ||...|  ||||.| .|..|
Grtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvl
0046846 (Phosphotyrosine protein) phosphatases II 76-284 1e-44 147.7 In-house 7-170 (176) alignment 
Range on Protein: 76-284
Range on HMM: 7-170/176.0
GDSESTDYINANWIDGFkqekKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEENEQYGeiivtleekeeladfeirkfflrkl
|. .. ||||||.|.|     ..||| ||  .|. ||..|..|.. ..||.||..||.|..||. ||||. .                            
gldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.........................

snqmetrmvkHFYFTSWPDHDVPEYaTGLLEFWKRVRNSWEGPqsGPITVHCSAGVGRTGTFIVIDAMMEqikeENLLDVYSYVSRIRAQRN-FMVQRPS
          ..... ||||.||.. . |||. . .|.  .    ||. ||||||.|||||..... ..     |. |.|.  ....|.||  ..|| |.
..........qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpe

QYSFIHYALL
|| |.....|
Qyrflyefel
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 26-286 3.5e-44 145.8 In-house 5-258 (267) alignment 
Range on Protein: 26-286
Range on HMM: 5-258/267.0
DLLFEKEYKDIKEPVNVTTRhCDN---LINKPKNRYGNIKAYDHSRVILSSVQGDsestdYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSS
.  .|||.. ||.  . ... .       |. .||. .   ||..||||.  . .     |||| ...|.|.....|.| .|   | .||. .. ..| .
eceiekefelikkisdtsst.isqsiaeknqernrlddnlpyddtrvilrtkeee.....yinasyvegyktknafivtqdplkntitdfltvihdqkvp

IVVMLTKLVEkGKVkcHKYWPEE---NEQYGEIIVTLEEKEELADFEIRKFFLrKLSNQMeTRMVKHFYFTSWPD-HDVPEYATGLLEFwkRVRNSWEGp
..|.|||  . ...  ...|| .    ..| .. |    ..|  |..|  . | |. |.  .. |  .|.  |    .   |   |.      .|  |  
vivlltkvft.dni..rlfwPPkmgqakkyqdltvehslekeendyqiitlel.kfknes.ahnvtlyyykkwnintnnkpylkplfgi..laknqlen.

QSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEA
 . |. |.||.||||.|||.|||...|..|.|. .|.. .. .|| ||  .|.   .| .||  | | 
gnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 337-571 8e-44 144.6 In-house 38-235 (392) alignment 
Range on Protein: 337-571
Range on HMM: 38-235/392.0
YTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEPLevffsaiytyl
 .| .. | ||||| |||| .. ||.|  | |  |. |.||||..... . |.||.|.|   ...||||||..|.|  |.|.  |.|             
tvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...........

cwwgggrwtlkktngvivseinfnpKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLqKARRKHLDRPVVVHCSDGVGRTGAFCTLFATLERVKLEG
                         |  ..| .. | . || .. || .  ... .| .. ||   .  .|...||| ||||||   .. . . . |   
.........................kgddartvaqfhftewPdkdvpkhtssllkfikev.kadfGqythpliihcsagvgrtgvvisidsvvahakktr

VLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAY
..|||     .| .|| ||   .|| . | |.|  
mvdvfnfvtnirrkrpymvqtkeqyafiygavled
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 39-285 2.4e-43 142.8 In-house 25-267 (281) alignment 
Range on Protein: 39-285
Range on HMM: 25-267/281.0
PVNVTTRHcDNLINKPKNRYGNIKAYDHSRVILSSVQGDSESTDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKC
| .. |   .. .|. |||| || . | ||| |     . .||||| ||.|     .. || | ||| || .|||||.|. ... .||| ...|  . ||
psdlctvf.nqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekc

HKYWPEENE---QYGEIIVTLEEKEELADFEIRKFflrKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNswegpQSGPITVHCSAGVGRTG
 .|.| .     |. .. |. |.      .   ..   .|| . |||.. |. .  ||| .||| .  .|.  ...|      .| |  .||||||||.|
aeyfprnahcclqfdklsvsyedstvnkslvttrl...nlsyegetrlithwlwkewpdwqvpessevmlkilrkira.....rstppvihcsagvgrsg

TFIVIDAMMEQIKEE-NLLDVYSYVSRIRA-QRNFMVQRPSQYSFIHYALLE
|.. ..  .. |.    | |.   ||..|   |   ||   || .|   ||.
tlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 319-570 5.3e-43 142.1 In-house 23-277 (439) alignment 
Range on Protein: 319-570
Range on HMM: 23-277/439.0
EREFQLLNGAVPDELSDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVML
. .|. .| . ||   .   |.|  .  |||| .. . .  ||.|  ||    . |||| |..|| ..  .||||.| ..| .||||.|... .  ||||
keifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivml

CGLNEPLEVFFSAIYTYLCW-WGGGRWTLKKTNGVIVSEINFNP--KTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKHLDRPVVVHCSDG
. | |    . |   ..           ..  | ||     ||   .|   | . .| |. | .. ||..   ..|..  .. |  |.   ||||||| |
tnlvesykywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsag

VGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILA
|||||.  .|  .||..|||  .|.    ..|| ||  || .| || . |.|.| 
vGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle
0041856 (Phosphotyrosine protein) phosphatases II 344-571 1.2e-42 140.9 In-house 1-170 (182) alignment 
Range on Protein: 344-571
Range on HMM: 1-170/182.0
NSKKNRYPNILPCERCRvvlpaipdkeDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCglneplevffS----Aiytylcww
| .||||..|||... |          | .||||... |..    |||||.||..|..||.||.... . .||.|.          .    .        
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..........eelywp........

gggrwtlkktngvivseinfnpkTGEVRQISHFMYLEWTEHAVPTkLLTIIDLIGDLQKarrkhLDRPVVVHCSDGVGRTGAFCTLFATLERvkleGvLD
                       . . |.. ...|| |  | ||. | ...|.| . ..      ..||.|||| ||||||... ..  ...    | ..
.......................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vs

VFITARMLRTQRPGMVSHLDQYRLCYEAILAY
.. . ...| .||||| ...||.... |.| .
leeavklvrsrRpgmvitpnqyfflqlallel
0049772 (Phosphotyrosine protein) phosphatases II 316-575 2.6e-42 141.0 In-house 19-283 (314) alignment 
Range on Protein: 316-575
Range on HMM: 19-283/314.0
TGLEREFQLLNGAVPDELSdFYTATQPKNSKKNRYPNILPCErCRVVLPAIPDkEDTTYINASYLEGYqekVAFIATQAPLDNTIEDF----------WR
..|. ..  ... |. ||. ...| ...| .||||..||| . .||.||  |  ... ||||||. |.    .|||||.||..|..||          ||
lklllvlnrrslsvlpelt.ilvadlflnrdknryldilpad.nrvilpglpv.sgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwr

MV--WHEEVFCIVM---------------------LCGLNEPLevffsaiytylCWWGGGRWTLKKtngvivseI-NFNPkTGEVRQISHFMYLEWTEHA
||  .   |  |||                     |..| ..            ...   .. | |           ..|     |.. ..... .. . 
mvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng...........neptaadlellk........eelydp.elferlgikylripvpDgs

VPtKLLTIIDLIGDLQKArrkHLDRPVVVHCSDGVGRTG--AFCTLFATLERVKLEGVLDVFITARMlRTQRPGMVSHLDQYRLCYEAILAYLDSF
.|  |  . ...  ...|   . ..||.|||..|.||||  ... .   | .| || .|. .  .|.    .||..  |.||  ..||.| ||. .
ap.lledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefilealleylkfl
0049260 (Phosphotyrosine protein) phosphatases II 88-281 2.8e-42 139.3 In-house 1-144 (152) alignment 
Range on Protein: 88-281
Range on HMM: 1-144/152.0
WIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWpeeneqygeiivtleekeeladfeirkfflrklsnqmetrmvkHF
.|||... ...|||.||  .|..|||||..|.. ...||||.|.|.||.||..|.                                           ..
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qy

YFTSWPDHDVPEYATGLLEFWKRVRNSwEGPQSGPITVHCSAGVGRTGTFIVIDAMMeqikeeNLLDVYSYVSRIRAQRNFMVQRPSQYSFIHY
... |||| ||. .  ||.. . ..      ..||. ||||||||||||..... |.      . .... .|...|..|. .|. |.|. |...
lhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_PTPN3_pd Subfamily PTPN3 321-571 6.9e-42 138.3 In-house 20-274 (280) alignment 
Range on Protein: 321-571
Range on HMM: 20-274/280.0
EFQLLNGAVPDElsDFYTATQPKNSKKNRYPNILPCERCRVVLpaipDKEDTTYINASYLE----GYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIV
.|. |    |.   .  .| .|.| .|||| .||| .  || |    ....| ||||.|..    . .  . .|||| ||..| .|||.|||....  ||
qfeqlyrkkpgl..aisaarkpenlsknryrdilpydatrvkl....kesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssliv

MLCGLNEPLEVFFSAIY---TYLCWWGGGRWTL---KKTNGVIVSEINFNPK-TGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRkHLDRPVV
||  | |   |     .   .  . .|. . ..   ..|. ... |.  . | | | |.| .. ||.|..|.||..   .....  ..|.|.   ..|||
mlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrs.gkeePvv

VHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAY
|||| |.|||| . .|  .|  .  .  . .    |..| ||  .|   .||..  ||||. 
vhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
subfamily_ptpA1_pd Subfamily ptpA1 14-247 8.1e-42 138.4 In-house 13-256 (418) alignment 
Range on Protein: 14-247
Range on HMM: 13-256/418.0
LKQHYLRMHAnsdllFEKEYKDIKEPVNV-TTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQgDSESTDYINANWIDGFkQEKKYIATIGPKAETTSDF
||.|   .|       ..|.. ..| |    |   |.  |  |||| ||   .|.|| |  .| | | .||||||.|||    |..|.| ||  .| .||
lknhikcihk.....ikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiq.dkegsdyinanyidga.ypkqfictqgplpntiadf

WRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEE--NEQ----------YGEIIVTLEEKEELADFEIRKFFLRkLSNQMETRMVKHFYFTSWPDHDVPEY
|||.|| .  |.|||..  |. ..|| .||||.   ||          .|   | | |  .  . ||    .| |. . ||| . .. .  ||||..|..
wrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnir.ltfegetrditqyqyegwpdhnipdh

ATGLLEFWKRVRNSWEG--P---QSGPITVHCSAGVGRTGTFIVIDAMMEQI
.  . .. . . |  .   |   .  || |||||||||||||     ||...
tqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 50-285 5e-40 132.0 In-house 53-287 (305) alignment 
Range on Protein: 50-285
Range on HMM: 53-287/305.0
LINKPKNRYGNIKAYDHSRVILSSVQgdseSTDYINANWIDG-FKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEE---
 |.. |||| .. . |.| | |.  .     .||| ||..   .  ||..|.. ||  .|  .|| |. ..|   .||| | || ||.|| .|||     
diaitknryqdvpcqdqsavkldkps....psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqge

-NEQYGEIIVT-L-EEKEELADFEIRKFFLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSwegpqSGPITVHCSAGVGRTGTFIVIDA
  |  . |.|  .   |    | ||.   |.   .  ..  |.|. .| |||  ||      ||.   .| |       || ||||||.||||| . |. 
klelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgs.....kvpivvhcsagigrtgtivaiey

MMEQIKEENLL-DVYSYVSRIRAQRNFMVQRPSQYSFIHYALLE
..|.| |..    .   |  .| || | .|   || |||  .|.
ilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln
0051429 (Phosphotyrosine protein) phosphatases II 372-579 7.7e-40 132.6 In-house 4-232 (272) alignment 
Range on Protein: 372-579
Range on HMM: 4-232/272.0
TTYINASYLEGYqekVA------FIATQAPLDNTIEDFWRMvWHEEVFCIVMLCGLNEplevffSAIYTYLCWWGGGRWTLKKTNGVIVSEINFNP----
..||||... ||           ......||..|..||||. ... . .||.|....|       . . . . | | |.    ...  . .|...     
sgyiNardvggy...grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeE......rgrlkcdrywpgirylhlpilddsaptilygalrvt

---------------------KTGEVRQISHFMYLEWTEHAVPTK-LLTIIDLIGDlqkarrkhlDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLD
                     ..||.|.. |..|. |  | ||.. ||....|. |         ..||.|||| |..||| .. |.  |..| || ..|
llseellldyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld.........ggpvlvHCsaGkdRTGtvvallllllgvsletivd

--------VFITARMLRTQRPGMVSHLDQYRLCYEAILAYLDSFEESQ
        .. . ..|| ||||.| . .||. .|||.|..|.|. ...
dYlltnlyleeaveelraqrpgavqteeqylflyeallellrsllsvr
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 318-571 1.7e-39 130.4 In-house 8-258 (267) alignment 
Range on Protein: 318-571
Range on HMM: 8-258/267.0
LEREFQLLNGaVPDELSDFYTATQPKNSKKNRYPNILPCERCRVVLPaipDKEDTtYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVM
.|.||.|..  . |. |   .    || ..||. . || .  ||.|    .||.  ||||||.|||. | |||.|| ||.||| ||. .. ...|  ||.
iekefelikk.isdtsstisqsiaeknqernrlddnlpyddtrvilr...tkeee.yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivl

LCGL-NEPLEVFFSAI------YTYLCWwgggRWTL-KKTNGVIVSEINFNPKTGEVRQISHFMYLEWTEHAVPTKLLtiIDLIGDLQKARRKHLDRPVV
|     . .  |.         |  |        .| |. |   .  .... |    .... . | .|   .     |    |.| | | . .  .||.|
ltkvftdnirlfwPPkmgqakkyqdltv....ehslekeendyqiitlelkfknesahnvtlyyykkwnintnnkpyl..kplfgilaknqlengnrPlv

VHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAY
|.|||||||.|.| .. . |||.| |||.|.|   | .| ||.|.|  ...|  ..| .  |
vacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
0044763 (Phosphotyrosine protein) phosphatases II 64-285 2.6e-39 130.1 In-house 2-169 (178) alignment 
Range on Protein: 64-285
Range on HMM: 2-169/178.0
YDHSRVILSSVQGdSESTDYINANWIDGFkqekKYIATIGPkaettSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEENEqygeiivtleekeela
.|..||.||...|  |..|||||..|...     |... .|     .|......|.. . .|.||. .| |..||..|||||..                
ldrtrvllsnleg.lersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

dfeirkfflrklsnqmetrmvKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEgPQSGPITVHCSAGVGRTGTFIVIDAMMEQikeeNLlDVYSYVSRIR
                      ..... .|||.||.    .||| . ...  . .. ||. |||||||||.||..... |...    .| .... ....|
.....................iqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvr

AQRNfMVQRPSQYSFIHYALLE
..|. .|..|.|. ....  |.
erRp.ivpnpgqlrqLyefelr
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 52-285 3.6e-39 129.3 In-house 48-285 (305) alignment 
Range on Protein: 52-285
Range on HMM: 48-285/305.0
NKPKNRYGNIKAYDHSRVILssvqGDSESTDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEEN-----
.. |||| ..   |. || |      .   .|| ||..    . |..| |  |  .| .||| | ...|   . || .|.|||  ||..|.. ..     
eagknrykdvgcldnnrvkl....egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvle

--EQYGEIIVTLEEKEEL-----ADFEIRKFFLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRnswegPQSGPITVHCSAGVGRTGTFIV
  |.   |.| .|  ..|     |. ....  |       ..| |.|...  |||  ||   . .||. .. |     |  |||.||||||.||||. ..
feekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekar.....pskgpivvhcsagigrtgsvvm

IDAMMEQIKEENLLD-VYSYVSRIRAQRNFMVQRPSQYSFIHYALLE
.. ...|. . . ..     . .|| |||  .|   || |.|  .|.
leyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 40-287 4.4e-38 125.9 In-house 25-270 (285) alignment 
Range on Protein: 40-287
Range on HMM: 25-270/285.0
VNVTTRHCDnlINKPKNRYGNIKAYDHSRVILSSvqgdsESTDYINANWIDG-FKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKC
 |.|    .   |   ||| .... . .||.|          ||| |.|.    |..  ||.| ||  || ||||.|... | . |.||  |.| |  ||
pnctytaye..anpdlnryadvrcieetrvvlkn.....hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekc

HKYWPEE---NEQYGEIIVTLEE-KEELADFEIRK-FFL-RKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSweGPQSGPITVHCSAGVG
  |.||.     ..|.  .|| | |||     | . . .        |   ..|     |||.  || |  ..|..| |..    |.  || ||||||||
alyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkv..npkekpicvhcsagvg

RTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAV
|| ||. ||    .| |.  ...   |  .|| |   ||   |. |..  |.| .
rtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 29-289 1.2e-37 124.6 In-house 21-273 (288) alignment 
Range on Protein: 29-289
Range on HMM: 21-273/288.0
FEKEYKDikEPVNVTTRHCDNLINKP-KNRYGNIKAYDHSRVILSsvqgdSESTDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVML
 .|||.|   | . . .  |. |..| ..|| |.   | .|| ||      ..  ||.|| .   | ... | .  |   |   .|.|. |     .|||
lkkeyrd..spneasidiidsfianptrdryenlprcditrvkls.....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivml

TKLVEKGKVKCHKYWPEENEQYGEIIVT-LEEKEELADFE-IRKFFLRKLSNQMETRM-VKHFYFTSWPDHDVPEYATGLLEFWKRVRNSwegpqSGPIT
..|.|||| |  .|.| .  .   |       |.. || . . |  | . |...|... ||. ..  |.|. |||     | . .....        || 
cellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlksl.....qkPiv

VHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTF
||.|||||||||.|.|  ..|... .. | . | ... |..|   .|   || ..|  .|| . .
vhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelll
0051082 (Phosphotyrosine protein) phosphatases II 80-284 1.5e-37 123.9 In-house 2-150 (151) alignment 
Range on Protein: 80-284
Range on HMM: 2-150/151.0
STDYINANWIDGFkqekkYIATIGPkaetTSDFWRMMWEHKSSIVVMLTKLVEKGkvKCHKYWPEENeqygeiivtleekeeladfeirkfflrklsnqm
 .||||.....|.     .... ||    ..||.....|.. . .|.|....| |  .|..|.||..                                 
lsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.................................

etRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNswegPQSGPITVHCSAGVGRTGTFIVIDAMMEQikeenlLDVYSYVSRIRAQRNFMVQRPSQYSFI
  . |.|.....|||...|..   .|||.. ...    ...||. ||||||.|||||..... |...      ..... .. .|..|  .|| . |. |.
..ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfq

HYALL
..|||
lfall
0043147 (Phosphotyrosine protein) phosphatases II 370-566 1.6e-37 124.2 In-house 3-155 (172) alignment 
Range on Protein: 370-566
Range on HMM: 3-155/172.0
EDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLneplevffsaiytylcwwgggrwtlkktngvivseinFNPKTGEVRQI
|...|||||||..|     |||||.||.||..|||||.... . .||.|..|                                     ........|..
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.....................................lydpellerlg

SHFMYLEWTEHAVPtKLLTIIDLIGDLQKARRKHLDRPVVVHCSDGVGRTGAFCTLFATLervklEGVlDVFITARMLRTQRPGMVSHLDQYRLCYE
 ...|| |  | ||  |  .....  ....  .  . ||.|||| ||||||... ..  |     .|. ... . ...|..|||.| . .|||..|.
iqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.....lgl.sleeavalvrekRpgavqnpsqyrflyy
0036282 (Phosphotyrosine protein) phosphatases II 372-566 4.2e-37 122.9 In-house 2-164 (174) alignment 
Range on Protein: 372-566
Range on HMM: 2-164/174.0
TTYINASYLEGYQEKVAFIATQAPLDntiedFWRMVWHEEVFCIVMLCGLNEPLeVFFSAIYT-YlcwwgggrwtlkktngvivseinfnPKTGEVRQIS
..|||||.| ..     .||.|.||.     ||.|.... . ..|||. ..|.   .    |.                            .. ..| . 
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelg.lykcinywpe.........................lredlerlgi

HFMYLEWTEHAVPTKLLtIIDLIGDLQKARRKHLDRPVVVHCSDGVGRTGAFCTLFATLERVKlEGVLDVFITARMLRTQRPGMVSHLDQYRLCYE
...|| |  | ||.    .....  ...|. .. ..||.|||| ||||||... ..  | . . |.. |.. . |.||.|||||| . .||| .|.
qylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 462-578 2e-35 117.4 In-house 170-286 (318) alignment 
Range on Protein: 462-578
Range on HMM: 170-286/318.0
KTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKHLDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQY
.. |.||.  . | .|... ||..  ...||... .|| .|.  .|.||||| |||||| |... . |||.| |...||| | ..||.||. ||   |||
eeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqy

RLCYEAILAYLDSFEES
 ..|...| .| |..  
efiydvllealasgdte
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 41-279 1.7e-34 114.0 In-house 33-273 (301) alignment 
Range on Protein: 41-279
Range on HMM: 33-273/301.0
NVTTRHCDN------LINKPKNRYGNIKAYDHSRViLSSVQGDseSTdYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKG
||||   |.       ..| |.|| ..    .. |    |.|       | ||||.   . ...||| ||  .|. ||| |.  ..   .|||.. ||| 
nvttidkdhitesyaylpkdkhryptvPckPstav.evivdGk..rv.PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekl

KVKCHKYWPEENEQ---YGEIIVTLEEKEELADFEI--RKFFLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSwegpqSGPITVHCSA
. ||..| | . ..    |   .....|| . . .|  |.. ..  .....|| | |. ...|.|..||.  . | .. . |..|       || |||||
eekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkks.....ekPivvhcsa

GVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFI
|.||. .||  . .  ... .. ...   . ..| .|   ||. ||  ..
GiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlywm
subfamily_PTPRG_pd Subfamily PTPRG 312-423 3.3e-34 113.0 In-house 15-127 (563) alignment 
Range on Protein: 312-423
Range on HMM: 15-127/563.0
GTGMTGLEREFQ-LLNGAVPDElSDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDT-TYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWH
  | .|...||. | .  ....  |  .. .|.| .|||| ||.. .| || |  .|.|...  ||||.|..||| . |||||| || .|..|||||.| 
adgdigfseefealqsetiskd.ldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWe

EEVFCIVMLCGLNE
..|  |||.  |.|
qnvaiivmitnlve
PTPc_DSPc_SM00012 184-285 5.1e-34 112.0 In-house 2-105 (105) alignment 
Range on Protein: 184-285
Range on HMM: 2-105/105.0
VKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGPQ-SGPITVHCSAGVGRTGTFIVIDAMMEQIKEE-NLLDVYSYVSRIRAQRNFMVQRPSQYSFIHY
|||...|.|||| |||... .||. . |... .  . |.|. |||||||||||||...| ...|...| . .|.. .|...| ||. |||.  ||.|.. 
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

ALLE
||||
alle
0046846 (Phosphotyrosine protein) phosphatases II 366-573 5.5e-34 112.8 In-house 6-174 (176) alignment 
Range on Protein: 366-573
Range on HMM: 6-174/176.0
IPDKEDTTYINASYLEGYqekvAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEPLEVFFSAI--------Ytylcwwgggrwtlkktngvivsei
. . .| .||||... |.    ..||||.|| .|..||..|.... . ..|.|. . |   . .  .        .                        
lgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi........................

nfnpktgevrqisHFMYLEWTEHAVPTKlLTIIDLIGDLQKARRKHldRPVVVHCSDGVGRTGAFCTLFatleRVKLEGVLDVFITARMLRTQRP-GMVS
             ....| | .| ||.    ...|.  ...|....  .||.|||| |.||||... ..     ..||  |.|. . ...| ||| |.| 
.............qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavq

HLDQYRLCYEAILAYLD
. .||| .||..| .|.
tpeQyrflyefellllk
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 343-569 7.7e-34 111.9 In-house 6-237 (239) alignment 
Range on Protein: 343-569
Range on HMM: 6-237/239.0
KNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQE-KVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEPLEVFFSAIYT-YLCWWG
 |  |||| ||.  .. ||||  . .   . |||||||  |.    |.||||  .  .  |||||.|.|    |||| || |  .      .      . 
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskyc

GGRWTLKKTNGV----IVSEINFNPKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKhLDRPVVVHCSDGVGRTGAFCTLFATLERVKLEG
  | ||.||. .    | . .  .    | | . .. .  | .. ||    ... |   . |       || |.||| ||||||||  . | | . | . 
nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslp.garpwvihcsagvgrtgaflvidamlrqakkqk

VLDVFITARMLRTQRPGMVSHLDQYRLCYEAIL
 .|.|   . .| .|| ||   .|| . . |.|
tvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 343-569 8.7e-34 111.7 In-house 7-238 (239) alignment 
Range on Protein: 343-569
Range on HMM: 7-238/239.0
KNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQE-KVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEPLEVFFSAIYT-YLCWWG
 |  |||| ||.  .. ||||  . .   . |||||||  |.    |.||||  .  .  |||||.|.|    |||| || |  .      .      . 
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskyc

GGRWTLKKTNGV----IVSEINFNPKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKhLDRPVVVHCSDGVGRTGAFCTLFATLERVKLEG
  | ||.||. .    | . .  .    | | . .. .  | .. ||    ... |   . |       || |.||| ||||||||  . | | . | . 
nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslp.garpwvihcsagvgrtgaflvidamlrqakkqk

VLDVFITARMLRTQRPGMVSHLDQYRLCYEAIL
 .|.|   . .| .|| ||   .|| . . |.|
tvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_PTPN9_pd Subfamily PTPN9 301-421 1.7e-32 107.7 In-house 1-119 (297) alignment 
Range on Protein: 301-421
Range on HMM: 1-119/297.0
MRLMQLAEKVAGTGMTGLEREFQLLNGAVPDelSDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTI
.....| . |  .|  || .|.. .    .     |... .. |..|||| ..|  .. ||||. ....| . ||||....||..| |||||| ||..|.
keieelvayvkekgkrGlskeyaeirnepve..GtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktv

EDFWRMVWHEEVFCIVMLCGL
.||||||| .||. |||   .
sdfWrmvWeqevlvivmttrv
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 337-423 2e-32 107.6 In-house 39-125 (318) alignment 
Range on Protein: 337-423
Range on HMM: 39-125/318.0
YTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNE
. ...| | .|||| |||. ...|| |  . ..|.. ||||.|..||..| |.||.|||| .||||||||||  .   ||||  ..|
lkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeee
subfamily_CG42327_pd Subfamily CG42327 52-214 5e-32 105.8 In-house 28-193 (319) alignment 
Range on Protein: 52-214
Range on HMM: 28-193/319.0
NKPKNRYGNIKAYDHSRVILSSvQGDSESTDYINANWIDGFKQE-KKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEE-----
 |.|.|. |.    ..||.| . .|| ... |..|... |...    |||.  .  ...|||||..|| .| ..| ||.| |.|  .| .|.| .     
skdksrvinvvPlPetrvvlqr.igdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldn

NEQYGEIIVTLEEKEELADFEIRKFFLRKLSnQMETRMVKHFYFtSWPDHDVPEYATGLLEFWKRVRNS
.. ||.| ||| ..|    . |  . |...  . |.| . |...  |.. .||   . |.    .||.|
tslyGdilvtlkgrevkdryaistlllkrvd.keesrelthywy.kwleaevPaeeaaliamllevrss
subfamily_Ptp69D_pd Subfamily Ptp69D 316-423 5.9e-32 106.0 In-house 22-127 (307) alignment 
Range on Protein: 316-423
Range on HMM: 22-127/307.0
TGLEREFQLLNGAvpDELSDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCI
 ||..|.. |.        .  .. .  |  ||||..| . .. ||.|. |. |||..|||||...||.||  ||| |.|...||.|||||..  ||  |
fglakeyekLear..eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtli

VMLCGLNE
|||  |.|
vmlsnlte
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 318-571 1.7e-31 103.9 In-house 13-268 (281) alignment 
Range on Protein: 318-571
Range on HMM: 13-268/281.0
LEREFQLLNGAVPDELSDFYtaTQPKNSKKNRYPNILPCERCRVVLPA-IPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIV
...||  | |  | .|   .   || | ||||| ||   .  || |   .|.|. | || | |.     |  .| || |  .|  |||||.|.|.  .||
fkqefsnlpgdppsdlctvf..nqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaiv

MLCGLNEPL-----EVFFSAIYTYLCWWG-GGRWTLKKTNGVI-VSEINFNpKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLigdLQKARRKhlDRPVV
||| . |       | |    .  | .      .     |  .  . .|.    || | |.|... || .  ||     .. .   |.| | .    | |
mlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnls.yegetrlithwlwkewpdwqvpessevmlki...lrkirar..stppv

VHCSDGVGRTGAFCTLFATLERVKLEGVL-DV-FITARMLRTQRPGMVSHLDQYRLCYEAILAY
.||| ||||.|.. ..  .|. ..    | |.  | ...  | |   |  |.|| | .. .| .
ihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
0049260 (Phosphotyrosine protein) phosphatases II 380-566 2.8e-31 103.7 In-house 2-144 (152) alignment 
Range on Protein: 380-566
Range on HMM: 2-144/152.0
LEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEPLEVFFSAIYtylcwwgggrwtlkktngvivseinfnpktgevrqisHFMYLEWTE
..||  . .|||||.|..||..|||||...  . .||||. | |  ....   .                                     ....| |  
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.....................................qylhlpwpD

HAVPTKLLTIIDLIGDLQKArRKHLDRPVVVHCSDGVGRTGAFCTLFATLervkleGVLDVFITARMLRTQRPGMVSHLDQYRLCYE
| ||.    ...|.  ..|. ... . ||.|||| ||||||... ..  |        .... . ...|..|||.| . .|.|..||
hgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 54-207 5e-31 102.6 In-house 35-189 (297) alignment 
Range on Protein: 54-207
Range on HMM: 35-189/297.0
PKNRYGNIKAYDHSRVILSSVQGDSestDYINANWIDgFKQE---KKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEE---NE
 |||| .| |.| .|| |  |  ..   |||||...  | .|    ||| . ||  .|  |||....|.   ..||..|| | |. ||  |||.    . 
rknryrdilatddtrvkllrviter...dyinadyvv.fpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerl

QYGEIIVTLEEKEeLADFEIRKFFLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEF
. |...|    .    .|.  ..   .|  . |.|.|.|  | ||||| ||     |  |
kagdvvveflsst.sdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrf
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 175-323 7.9e-30 98.5 In-house 82-230 (440) alignment 
Range on Protein: 175-323
Range on HMM: 82-230/440.0
LSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPS
  | .|.| .|.... .|||. ||..|  .|.. . | .| |   .||. ||||||.||||  |..|... . |  . .|..|... .| .|  ||| | 
yingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpe

QYSFIHYALLEAVTFGDTEIEVQNLRMRLMQLAEKVAGTGMTGLEREFQ
||.|.| |.||..  ||| |  ...  |. |.      |  . |..||.
qyafvheavlegllcgdtliledditerveqiqwpnphtdksplqqefe
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 53-294 5.6e-29 95.7 In-house 53-296 (310) alignment 
Range on Protein: 53-294
Range on HMM: 53-296/310.0
KPKNRYGNIKAYDHSRVILSSvqGDSESTDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEE--NEQYG
  |||| ..   | ||| |      |   ||| ||..      . .| . ||   |  |||||... ..  ...| | .|.|. ||  |||     | ||
mhknrysdvvcldtsrvklki..dksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetyg

EIIVTlEEKEELADFEIRKFFLR---------KLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEfwKRVRNSwegPQSGPITVHCSAGVGRTGTFIVID
 | || .  |   .||| .. .          .   ...   |.   .  |||  ||.     .   .|.       . ||  ||||||..|... . ..
cirvt.nlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp..qrllaq...vrhgpcvvhcsagkdrlyvvvalk

AMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLeAVTFGDTEI
  ...... . .|.   .. .. .|   .| . || .|..  . . . |.||.
lkidkldrglkvdaeevktellksraiciqtelqyliidrvri.ifargetev
0051082 (Phosphotyrosine protein) phosphatases II 371-568 9.1e-29 95.4 In-house 2-149 (151) alignment 
Range on Protein: 371-568
Range on HMM: 2-149/151.0
DTTYINASYLEGYqekvaFIATQAPLDntieDFWRMVWHEEVFCIVMLCGLNEPLevffsAIYTYLCWWGggrwtlkktngvivseinfnpktgevRQIS
 ..|||.||..|.     ......||.    ||....... . .||.|... |.        . ||  .|                          ... 
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg.....ycpeylpelg..........................ievl

HFMYLEWTEHAVPTKLLTIIDLIGDLQKarrkHLDRPVVVHCSDGVGRTGAFCTLFATLERvklegvLDVFITARMLRTQRPGMVSHLDQYRLCYEAI
|. .| |... .|. . ......  |..    . . ||.|||| |.||||... |.  |..      .... . ...| .|||.| . .|..... |.
hipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfal
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 342-573 1.2e-28 94.6 In-house 52-284 (290) alignment 
Range on Protein: 342-573
Range on HMM: 52-284/290.0
PKNS--KKNRYPNILPCERCRVVLpaiPDKEDTTYINASYLEGYqeKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEPL----EVFFSAIYTY
 ||.  ||||| ..   .. ||.|    |  |  |. | |..|   |  || || .| .|. |.|||| .|.|  ||||| | |      | ..      
dkntefkknrykdvvcndktrvil...kdGydGdyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGe

LCWWggGRWTL------KKTNGVIVSEIN-FNPKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKArrkhlDRPVVVHCSDGVGRTGAFCTLFAT
   .  | .|.      .| . .|   .   . ..|   .. |.    | ...|.   |... ..  |.||       ||||||| |.||||.| .. ..
vltf..GeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka.....sGpvvvhcsaGiGrtGtfvaievg

LERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYLD
|. .     ||.  . | ||  | . |    || .  |..| .  
lqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGk
subfamily_PTPRK_pd Subfamily PTPRK 336-424 3.4e-28 93.4 In-house 35-123 (314) alignment 
Range on Protein: 336-424
Range on HMM: 35-123/314.0
FYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEP
. .| . .| .|||. .||. .|.||.| .| .  .. ||||.....|.   |||.|| ||..|..||||.|..|.  .||||  | | 
wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvev
PTPc_DSPc_SM00012 469-569 5.1e-28 92.7 In-house 2-104 (105) alignment 
Range on Protein: 469-569
Range on HMM: 2-104/105.0
ISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKHL-DRPVVVHCSDGVGRTGAFCTLFATLERVKLE-GVLDVFITARMLRTQRPGMVSHLDQYRLCYE
..|. |..|..| ||..   |..|. ...| ..|.    |||||||.|||||| |..|   |.... | . .|.| . ..||.||||||. ..||  .|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AIL
|.|
all
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 30-286 9.8e-28 91.7 In-house 22-275 (312) alignment 
Range on Protein: 30-286
Range on HMM: 22-275/312.0
EKEYKDIKEPVnvTTRHCDN-LINKPKNRYGNIKAYDHSRVILSsvqGDSEstDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLT
 |||| . . |  .   |   |  |  ||| ||. .|  |  |.   || .   || ||..    . .....| ||  .|.. ||..     |. ...|.
tkeykavgniv..sdsectaflkfkdlnrypniqcwdrgrftla...gden..fyihanfvkictkperfvctqgplentcthfwqlalslgstsiillc

KLVEKGKVKCHKYWP--------EENEQYGEIIVTLEEKEELADfEIRKFFLRKL-SNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNswegpQ
 .|| |  || ||          |.   | |    .|      |  | .  |. .     .   ..|. ..||||| .|.     | .   |..     .
gfvedgsekcakyisdivgfvdledhrvyteycteieiggkskd.kithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkk.....d

SGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEA
  |.  |||||||||||...|..|.  ..     .|      .| .|   |.   || .   ..|| 
kkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlef
subfamily_PTPRK_pd Subfamily PTPRK 463-570 1.2e-27 91.6 In-house 169-275 (314) alignment 
Range on Protein: 463-570
Range on HMM: 169-275/314.0
TGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKhLDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYR
  |.|.. .| .| |..| ||..  ....|.  ..| . .  . ..||||| | ||||.|...   |. .. |||.||| ... ||.... ||   .||.
qeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqyk

LCYEAILA
..|..|| 
fiydvile
subfamily_PTPRD_pd Subfamily PTPRD 506-577 2.3e-27 90.9 In-house 215-286 (564) alignment 
Range on Protein: 506-577
Range on HMM: 215-286/564.0
RPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYLDSFEE
 |.||||| ||||||.|... | |||.| |...|.. . ..||.||. ||   .||  ..|||| .|.....
gPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnt
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 309-572 3.4e-27 90.2 In-house 12-271 (288) alignment 
Range on Protein: 309-572
Range on HMM: 12-271/288.0
KVAGTGMTGLEREFQLLNGAVPDELSDFYTAtqpkNSKKNRYPNILPCERCRVVLPaipDKEDtTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVW
.|   .. ||..|..      . .  | . |    |. ..|| |.  |. .|| |    |  |  ||.|  .   . |  .| .||||. ||| .|.|. 
lvlqiaveglkkeyrdspneasidiidsfia....nptrdryenlprcditrvkls...ddpd.fyiaanvvssakykrrlicaqaPlngtieelWkmll

HEEVFCIVMLCGLNE----PLEVFFSAIYTYLCWWGGGRWTLKKT----NGVIVSEINFNPKTGEVRQ-ISHFMYLEWTEHAVPTKLLTIIDLIGDLqka
...|  ||||| | |      ...|          |      ||     . ...  .  . |.|| .. . .  .||| ...|| . |. . |.  |   
esdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl...

rrKHLDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYL
  | |..|.|||.| ||||||..   .  || ..|.  | .      || .|   .    ||   .  .| .|
..kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleel
0048076 (Phosphotyrosine protein) phosphatases II 151-284 3.5e-27 90.2 In-house 15-140 (145) alignment 
Range on Protein: 151-284
Range on HMM: 15-140/145.0
EIIvTLEEKEELADFEIRKFFLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGPqsGPITVHCSAGVGRTGTFIVIDAMMEqikeE
 .  | .. |.|.|. |.  .      . ..|.. ......||||.||. .  |||| . ...  . .  ||. ||||||||||||..... |..    .
slp.taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmll....l

NlLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALL
. ..... . ..|.|| ..|..|.|. |.....|
g.vsleealelvrsqrpgavpnpgqlrflyefel
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 342-423 3.7e-27 90.0 In-house 18-100 (270) alignment 
Range on Protein: 342-423
Range on HMM: 18-100/270.0
PKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQE-KVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNE
 ...| ||| .|||  . ||.|. . ... |.|||| |..|... | ..||...||..|...||||.|.|.| .|||. ||.|
argkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleE
subfamily_PTPN6_pd Subfamily PTPN6 293-422 7e-27 89.2 In-house 3-133 (306) alignment 
Range on Protein: 293-422
Range on HMM: 3-133/306.0
EIEVQNLRMRLMQLAEKVAGTGMTGLEREFQLLNGAVPDELSDFYTATQPKNSKKNRYPNILPCERCRVVLPaIPDKEDTTYINASYLEGYQ--EKVAFI
..  .... |  .| ..   .. .|.| ||. |.     .| .   ...|.| .|||| |||| .  ||.|   |.  ...||||.|... .  .. ..|
sllakeieqrvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyi

ATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLN
|||  |..|..||||||| |.   |||.   .
atqgclettvsdFWrmvwqensrvivmttkev
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 102-302 8.1e-27 88.9 In-house 39-235 (255) alignment 
Range on Protein: 102-302
Range on HMM: 39-235/255.0
IgpkaeTTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEENEQ---YGEIIVTLEEkeELADFEIRKFF-LRKLSNQMETRMVKHFYFTSWPDHDV
.     |   |....   |.. ||||. . |.|..||..|.| | ..   . .. ||  .    ||  .|    . .|... .|. |||. .. |...  
l.....tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWiekna

PEYATGLLEFWKRVRNSwEgpqsgPITVHCSAGVGRTGTFIVIDAM----MEQIKE--ENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVtFGD
|| |  .|. .| ||.|       .. ||||.|.||. .|.... .    . ....     ||  | .  .| .|.  .. | | .|  . .|. | |  
Pelareilnilkvvrds.k.....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv.fpk

TEIEVQNLRMR
.|.| .  ..|
geleakyqeir
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 450-573 1.9e-26 87.4 In-house 172-294 (301) alignment 
Range on Protein: 450-573
Range on HMM: 172-294/301.0
NGVIVSEINFNPKTgEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKHLDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRT
|| | .... . .  . ...  .   .| .. |     |..  | |  ....|    ||||||||.|.|.| .|..  .|| .| ||| |||   . .| 
ngyierkfkvksdk.sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrr

QRPGMVSHLDQYRLCYEAILAYLD
..||.|  |.||   |..|  || 
skpgaVtTLeqytsiydvidmylq
0048179 (Phosphotyrosine protein) phosphatases II 175-281 3.2e-26 87.2 In-house 40-139 (144) alignment 
Range on Protein: 175-281
Range on HMM: 40-139/144.0
LSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEgpQSGPITVHCSAGVGRTGTFIVIDAMMeqikEENlLDVYSYVSRIRAQRNFMVQRPS
  .. ..|.. ......||||.||.... |||| . ...  |  ..||. ||||||||||||..... |.    ... |.... . ..|..| ..|. |.
yepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpg

QYSFIHY
|. |...
qlrfLle
subfamily_PTPN13_pd Subfamily PTPN13 448-574 4.3e-26 86.8 In-house 146-271 (273) alignment 
Range on Protein: 448-574
Range on HMM: 146-271/273.0
KTNGVIVSEINFN-PKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRkhLDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARM
| .|  |.... .  ..||.|...|. . .| .| ||.. . .. ..  ... ..     |.||||| |.||.|.. |. . |. .. .  .||  . | 
kldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrk

LRTQRPGMVSHLDQYRLCYEAILAYLDS
|| || |.|   ||| ..|.|||  | |
lreqrqgvvqtkdqyifvykailevlks
subfamily_Ptp69D_pd Subfamily Ptp69D 460-573 7.7e-26 85.9 In-house 175-287 (307) alignment 
Range on Protein: 460-573
Range on HMM: 175-287/307.0
NPKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKHlDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLD
 ..  . |..  . |..| .  ||    ....||  ...  ...   |.||||| ||||.| | .|   |...|.|  .|.| | . || ||. .|  |.
sgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsle

QYRLCYEAILAYLD
||  .| |.| | .
qYvflyralldyss
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 380-567 1.5e-25 84.5 In-house 229-433 (440) alignment 
Range on Protein: 380-567
Range on HMM: 229-433/440.0
LEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEPLEVFFSAIYTYLCWWGG---GRWTLKKTNGVIVS--EINFNPKTGEVRQISHFMY
.|||  | |||||| ||| |. ||||.|   ..  |.||  ||.     .  . |    .|    |    .. | | |   |.... .  |.||.    .
fegyskknafiatqmpldstvldfwrlvhdyristiimlnqlndktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkykeevheirqfevqtw

LEWTEH-AVPTK---LLTIIDLIGDLQKA---RRKH-----LDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYR
  | .   | ..   . ....|.  |.|    |           |..|||  |.  .| |||..  ||... .| .|||   |.||  || .|  | .| 
ptwiqsdgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvptltdyl

LCYEA
|||  
lcykl
subfamily_CG7180_pd Subfamily CG7180 445-571 3e-25 83.5 In-house 158-289 (296) alignment 
Range on Protein: 445-571
Range on HMM: 158-289/296.0
TLKKTNGVIVSEINFNPKTGEVRQISHFMYLEWTE-HAVPTKLLTIIDLIGDLQKARRKH----LDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLD
|.| |  ..    . .. . |.| . .| . ||   . ||    ..|.|.   .. |.|        ||||..|||..|.|..... |.|| |. |. .|
tfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevd

VFITARMLRTQRPGMVSHLDQYRLCYEAILAY
||  ...|| .||..|   ..|. .|. .| .
vFeavktlrrsRpqLvenveeYkyiYdvllea
0044763 (Phosphotyrosine protein) phosphatases II 355-568 4e-25 83.9 In-house 1-167 (178) alignment 
Range on Protein: 355-568
Range on HMM: 1-167/178.0
PCERCRVVLPAIPDKEDTTYINASYLEGYqekvaFIATQAPLdntiEDFWRMVWHEEVFCIVMLCGLNEPLevfFSAIY-------Tylcwwgggrwtlk
|..|.||.|. ... | . |||||.  ..     ......|     .|...... . . .||.|..  |.    |   .                     
pldrtrvllsnleglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelg...flkcdpywpeeag.............

ktngvivseinfnpktgevrqiSHFMYLEWTEHAVPTKLLTIIDLIGDLQKAR-RKHldRPVVVHCSDGVGRTGAFCTLFATLERvkleGVlDVFITARM
                       ..... .  | ||. |  . ...  ...|. .|.  .||.|||| ||||.|... ..  ...    |. ...   ..
......................iqylhipipDhgvpdllehflefvefieealdekg..gpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaiel

LRTQRPgMVSHLDQYRLCYEAI
.| .|| .| . .|.| .||  
vrerRp.ivpnpgqlrqLyefe
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 306-419 4.1e-25 83.5 In-house 5-116 (281) alignment 
Range on Protein: 306-419
Range on HMM: 5-116/281.0
LAEKVAGTGMTGLEREFQLLNGAVPDELSDfyTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWR
 ...      .|. .|.. |. .  |. .    .....| .|||| ||   .  ||..    ....| ||||....||... ..||||.|. .....||.
hlkqlsqndnaGfieeyeklaaigvdntat..askadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWq

MVWHEEVFCIVMLC
||| ..|  |||. 
mvweqkvsaivmvt
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 447-573 5e-25 83.0 In-house 133-265 (270) alignment 
Range on Protein: 447-573
Range on HMM: 133-265/270.0
KKTNGVIVSEINFNpKTGEVRQISHFMYLEWTEHAVPTKLL------TIIDLIGDLQKARRKHLDR-PVVVHCSDGVGRTGAFCTLFATLERVKLEGVLD
.|..| |. ... . ..|| |.. ||.| .| .|.||..         .. .. .... .... .  |..||||.|||||| . .|  ... .. .. .|
ekeegyiltrlrle.ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvd

VFITARMLRTQRPGMVSHLDQYRLCYEAILAYLD
|    . || .|. .|.| .||.. |.|.. | .
vlaiieelRkdRmalvqhpeqyeflykavveyae
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 345-551 5.7e-25 82.7 In-house 51-260 (301) alignment 
Range on Protein: 345-551
Range on HMM: 51-260/301.0
SKKNRYPNIlPCERCRVVlPAIPDkEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEPLEVFFSaiyTYLCWW-----
 .|.|||.. ||.    |   | |      | | ...   .   |||||.||.|| |||| |. . .|  ||||.   | ||   .   .||  .     
kdkhryptv.PckPstav.evivd.GkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekce...eylpvkisekl

GGGRWTLKKTNGVIVS-------EINFNPKTGE--VRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKArrkhlDRPVVVHCSDGVGRTGAFCTLFATLE
  ||...| .|   .        ... .  ||.   | . |. | |||.. ||     . ||.  ..|.     ..|.|||||.|.||. || .      
digrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkks.....ekPivvhcsaGiGrsvafigteylar

RVKLEGVLDVFITARMLRTQR
.|. .  ...  . . || .|
eveadptieltealkhlrehr
subfamily_PTPN6_pd Subfamily PTPN6 462-574 7.5e-25 82.5 In-house 181-299 (306) alignment 
Range on Protein: 462-574
Range on HMM: 181-299/306.0
KTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKHL---DRPVVVHCSDGVGRTGAFCTLFATLERVK---LEGVLDVFITARMLRTQRPGMV
| .| |.. .. . .| .|.||..  ...|.. |... ...      .|.|||||.|.||||.|  . . |. ..   |.  .|.  . ...|.|| |.|
kkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglv

SHLDQYRLCYEAILAYLDS
   .||.. |.|| .|...
qteqqykfvykaikkyiet
subfamily_PTPN9_pd Subfamily PTPN9 460-572 9.2e-25 82.3 In-house 166-290 (297) alignment 
Range on Protein: 460-572
Range on HMM: 166-290/297.0
NPKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKA-----------RRKH-LDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARML
| ||.| |...|| .| | .. ||    ...|..   ...            . |  . |.||||| |.||||.|.||  .|.|.. .|..||. | ..|
nvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkll

RTQRPGMVSHLDQYRLCYEAILAYL
||||  ..   .|| .|| |.| | 
rtqrafsiqtpeqyefcylavleya
subfamily_CG7180_pd Subfamily CG7180 339-420 9.8e-25 81.8 In-house 37-118 (296) alignment 
Range on Protein: 339-420
Range on HMM: 37-118/296.0
ATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCG
. . .| .|||.....| .  ||||. .  .|.. ||||.| ...  | ..| |.|| ..|...|||.|. ||. ..|.|. 
glrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtk
subfamily_ptpA1_pd Subfamily ptpA1 318-420 4.5e-24 79.9 In-house 23-122 (418) alignment 
Range on Protein: 318-420
Range on HMM: 23-122/418.0
LEREFQLLNGAV-PDELSDfytATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKvAFIATQAPLDNTIEDFWRMVWHEEVFCIV
.. ||.||. .| | | |.     . .|. |||| |||| .. || |  | ||| . |||| |..|   |  ||.|| || ||| ||||||| . .  ||
ikeefrlleesvgpsetse...gdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk.qfictqgplpntiadfwrmvwenrcriiv

MLCG
||  
mlsr
subfamily_egg_pd Subfamily egg 41-285 4.7e-24 79.6 In-house 31-271 (307) alignment 
Range on Protein: 41-285
Range on HMM: 31-271/307.0
NVTTRHCDNLINkpKNRYGNIKAYDHSRVILSSVQGDSeSTDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKgkVKCHK
..||   ||  .  | |   ..  | ||| |   .|   . |.| || ..|     ..| .  |  .|  |||||... .   .||||  .|    .|. 
slttaasdnnle..karskrvhckdssrvklelrrGqy.lddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..ercey

YWPEENEQ---Y--GEIIVTLEEKEELADFEIRKFFLRKLSNQMETRMVKHFYFTSWPDHDVpeyaTGLLEFWKRVRNswegpQSGPITVHCSAGVGRTG
|||  ...   .  | . ..  . .. ||   |   |. .  . | | ..|.        ||       |.  ...||      | |. |..  || ...
ywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqgdvnnssdv....ysplrvlrklrn.....lskpvvvqdilGvskaa

TFIVID-AMMEQIKEEN-LLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALL---E
|.. |. |... ..       |   |  .| .|.. |. . .| |..  .|    
tlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffr
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 93-280 8.8e-24 78.8 In-house 2-197 (199) alignment 
Range on Protein: 93-280
Range on HMM: 2-197/199.0
KQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEEN---EQYGEIIVTLEEKEELADFEIRKFFLRK-LSNQMETRMVKHFY
| ...||||  |  || .|||.|.||  |  .||.     . ..    |||  .    .|| . || .     .|. |  . | .  .    || . |. 
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

FTSWPDHDVPEYA--TGLLEFWKRVRNSWEGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEE--NLLDVYSYVSRIRAQRNFMVQRPSQYSFIH
|||| ..  |. |   |..   . | . .|  .  |. |||| | | || |. .|  .   .|    ..|..    |.|  |  ..    .| ||.
ftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 88-280 1e-23 78.3 In-house 82-281 (302) alignment 
Range on Protein: 88-280
Range on HMM: 82-281/302.0
WIDGFKQEKKYI-ATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEENE---QYGEI-IVTLEEKEELADFEIRKFF-LRK--LSN--
 .|| .. .|     | || .|.  .| .. ... .||| |...||... || .|. .. .   ..|.  . |.. |..|..|  .| | | .  . |  
pmdGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknek

--QMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVrNSWEgpqsGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQ
  .   . |. ..|..||||  |. |   |.  |   .|.       . ||||||||||||.. |   ..  ....  |. | |  .|. |   ||  .|
kkkkvkktvdilafsawpdhGapkeaytaldilkfc.esyk....knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqq

YSFIH
  .. 
liyll
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 94-280 1.2e-23 78.4 In-house 2-196 (198) alignment 
Range on Protein: 94-280
Range on HMM: 2-196/198.0
QEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEEN---EQYGEIIVTLEEKEELADFEIRKFFLRK-LSNQMETRMVKHFYF
 ...||||  |  || .|||.|.||  |  .||.     . ..    |||  .    .|| . || .     .|. |  . | .  .    || . |. |
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TSWPDHDVPEYA--TGLLEFWKRVRNSWEGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEE--NLLDVYSYVSRIRAQRNFMVQRPSQYSFIH
||| ..  |. |   |..   . | . .|  .  |. |||| | | || |. .|  .   .|    ..|..    |.|  |  ..    .| ||.
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 451-574 2.2e-23 77.8 In-house 154-278 (281) alignment 
Range on Protein: 451-574
Range on HMM: 154-278/281.0
GVIVSEINFNPKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKHLDRPVVVHCSDGVGRTGAFCTLFATLERVKLE-GVLDVFITARMLRT
  |  ... . ..|| |..... |. | .| ||..   ...   ...|...|. . |.|.||| ||||||.. .|   ...|. |   |||  . . || 
tyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrk

QRPGMVSHLDQYRLCYEAILAYLDS
.|  ||  . ||.  | |.| .|| 
ernlmvqtvvqyefvykavldaldk
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 54-160 3.3e-23 77.0 In-house 49-166 (350) alignment 
Range on Protein: 54-160
Range on HMM: 49-166/350.0
PKNRYGNIKAYDHSRVILS-------SVQGDSESTDYINANWIDGF----KQEK--KYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHK
 |||| ||  |.||||.|        ...   .. ||||||..       ...   ||||| .|  .|  ||.... . |  ....||..|| .  ||..
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPEENeqYGEIIVTLEEKE
||.| .  | .| | |..| 
YWqegs..ydditvklaskw
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 333-418 1.4e-22 74.8 In-house 27-111 (287) alignment 
Range on Protein: 333-418
Range on HMM: 27-111/287.0
LSDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKeDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVML
   | .|..  . ||||| ..|| .  ||.| | ...  . |||| |. .|... ||||.|.|.  |. ||||.|.....  ....
tatfkaaeelaavkknryadvlPiddtrvllsaegel.GsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitm
subfamily_PTPRG_pd Subfamily PTPRG 464-577 2.3e-22 73.9 In-house 180-292 (563) alignment 
Range on Protein: 464-577
Range on HMM: 180-292/563.0
GEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKHlDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRL
 ..... .. | .| .|.||.. |  .  .   ..|....   |.||||| |||||| .. | . |.... | . .|| .....|.||. .|   .||  
dteklvrqyhytkWPdhgvPehslpvLifvkkssaankae.aGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYif

CYEAILAYLDSFEE
 ..|.|  . | |.
lhdalleaiasket
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 338-423 7.4e-22 72.4 In-house 34-121 (301) alignment 
Range on Protein: 338-423
Range on HMM: 34-121/301.0
TATQPKNSKKNRYPNILPCERCRVVLPAIPD--KEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNE
  .. .|.. ||. || . .  |..|   |.  .  ..||||||..||.|| .|||.|.|...|. ||||..|.| .  |||...|.|
vglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlke
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 60-309 9.1e-22 72.5 In-house 26-265 (290) alignment 
Range on Protein: 60-309
Range on HMM: 26-265/290.0
NIKAYDHSRVILSsVQGDSESTDYINANWIDgFKQEKKYIATIGPKAET-------TSDFWRMMWEHKSSIVVMLTKLVEKGKV----KCHKYWPEENE-
..    ..||.|  . |   . ||| || .  . .  . |.|  |....         .|| |. . |.  |||| .  || .      | || ||. . 
evpLveatrvvLk.gygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvge

--QYGEIIVTLEEKEELADFEIRKFFLRkLSNQmETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSwegpqSGPITVHCSAGVGRTGTFIVIDAMME
  ... . |   .||.  |.|.|.  ..   .. |   |.|  . .| .  |.|    ||.  . |..|       |. |||  |. |  ..  |.  . 
elkfkgltvkCkskekeddvetRelvvk.fdde.eeftvtHsllkgWnklnvqedtktllsliqkvkas.....ktpvivHcvdGiSrsAalaaiilgyQ

QIK-EENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLeavtfgdteievqnlrMRLMQLAEK
 |   .. . . . .. .| ||. ..... ...|. ....                .....  ..
kiaetsgsvkledvlkalrkqralaitsalelafvdagiv................llaievldq
subfamily_hpo-7_pd Subfamily hpo-7 107-299 9.5e-22 72.1 In-house 45-243 (263) alignment 
Range on Protein: 107-299
Range on HMM: 45-243/263.0
ETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEENE---QYGEIIVTLEEKEElaDFEIR-KFFLRKLSNQMETRMVKHFYFTSWPDHDVPEYAT
.|   |....   |.. ||||.   |.|..|| .|.| | .   .. .. |.  .  .  |  .. . .|  |... .|. |||. .. |...  || | 
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpelar

GLLEFWKRVRNSwEgpqsgPITVHCSAGVGRTGTFIVIDA----MMEQIKEE--NLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFG--DTEI
  |.  | .|||       .. ||||.|.||.  | |..     |. ....     ||  | .  .| .|.  .. | | .|  . .|. |       |.
eilnilkvarns.k.....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfakgel

E--VQNL
|   |..
eakyqei
subfamily_PTPN14_pd Subfamily PTPN14 334-422 2.3e-21 71.1 In-house 39-128 (300) alignment 
Range on Protein: 334-422
Range on HMM: 39-128/300.0
SDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKeDTTYINASYLEG--YQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLN
....||. |.| .|||....|| | .|| | .  .. .| ||||| ..     ..  .|..|.||..|..|||.||| ..|  ||||   .
allstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteee
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 387-566 6.7e-21 69.4 In-house 5-198 (199) alignment 
Range on Protein: 387-566
Range on HMM: 5-198/199.0
VAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEPLEV----FFSAIYTYLCWWGGGRWTL----KKTNGVIVSEINFNPKT--GEVRQISHFMYLE
  .|||| || .|. |||.|||      |||.   .   |.    ....  .    .|    |      | . .|.. |  |  |     |.|||. .  
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WTEHAVPTKLLTIIDLI--GDLQKARRKHLDRPVVVHCSDGVGRTGAFCTLFATL---ERVKlEGVLDVFITARMLRTQRPGMVSHLDQYRLCYE
| |.. |   | .  ..   .. |   .  | ||.|||||| | || | .|   .   |  |   |.|.|  |. ||  | |..| |..| . |.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 388-566 7.7e-21 69.2 In-house 5-197 (198) alignment 
Range on Protein: 388-566
Range on HMM: 5-197/198.0
AFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEPLEV----FFSAIYTYLCWWGGGRWTL----KKTNGVIVSEINFNPKT--GEVRQISHFMYLEW
 .|||| || .|. |||.|||      |||.   .   |.    ....  .    .|    |      | . .|.. |  |  |     |.|||. .  |
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

TEHAVPTKLLTIIDLI--GDLQKARRKHLDRPVVVHCSDGVGRTGAFCTLFATL---ERVKlEGVLDVFITARMLRTQRPGMVSHLDQYRLCYE
 |.. |   | .  ..   .. |   .  | ||.|||||| | || | .|   .   |  |   |.|.|  |. ||  | |..| |..| . |.
kekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_CG42327_pd Subfamily CG42327 342-495 2.9e-20 67.2 In-house 26-189 (319) alignment 
Range on Protein: 342-495
Range on HMM: 26-189/319.0
PKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQE-KVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEPL-EVF---F--SAIYT
.   .|.|. |..|    ||||. |.|.. . |..|||. ||.. .  .||.|..|...  ||||.||      || |. | |   .|    .  ..   
vtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketld

YLCWWGGGRWTLKKTNG---VIVSEINF-NPKTGEVRQISHFMYlEWTEHAVPTKLLTIIDLIGD
    .|  . |||. .     ..| . . . .  | |...|. | .| |  ||..  ..| .. .
ntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamlle
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 337-571 3.1e-20 67.3 In-house 29-269 (285) alignment 
Range on Protein: 337-571
Range on HMM: 29-269/285.0
YTATQpKNSKKNRYPNILPCERCRVVLpaipDKEDTTYINASYLEG-YQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEP----LEVFFSA
||| .  |   ||| ..   |  ||||     . |  || ||..    ... ..|.|| || .|. |||.|...|..  ..||| | |       ...  
ytaye.anpdlnryadvrcieetrvvl....knhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyype

IYTYLCWWGGGRWTLKKTN-----GVIVS---EINFNPKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKhlDRPVVVHCSDGVGRTGAFC
    .  .|    || . .     | |.     || .  . |   . |     | ..  |     .|.|   ..|   |  ..|..|||| ||||| .| 
klgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk..ekpicvhcsagvgrtatfv

TLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAY
 .  .  |.  .  ....   | .|. |   |    |. . |  .. |
gidyatirimenpniemldivremramrfqavqshmqflflyvvlmey
0048076 (Phosphotyrosine protein) phosphatases II 459-571 5e-20 67.1 In-house 37-142 (145) alignment 
Range on Protein: 459-571
Range on HMM: 37-142/145.0
FNPKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKHldRPVVVHCSDGVGRTGAFCTLFATLErvklEGvLDVFITARMLRTQRPGMVSHL
 . .....|.. ...|| |  | ||. | ......  ...|....  .||.|||| ||||||... ..  |.    .| .... . ...|.||||.| . 
tselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqrpgavpnp

DQYRLCYEAILAY
.|.| .||..| .
gqlrflyefelel
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 49-286 5.7e-20 66.1 In-house 44-278 (303) alignment 
Range on Protein: 49-286
Range on HMM: 44-278/303.0
NLINKPKNRYGNIKAYDHSRVILSsvqgDSestDYINANWIDgFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEENEq
 . |  |||. ..   |||.| ||    ||    || |.... .. .|| | |  | . |..|||.|. | |   |..|    |  |.  .  .|.... 
fvknmdknrfvdvicldhskvkls....ds...syihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqd.

YGEIIVTLEEKEELADFEIRKFFLR---KLSNQMETRMVKHFYFTSWPDHDVPEYA--TGLLEFWKRVRNSWEGPQSGPITVHCSAGVGRTGTFIVID-A
. ..        |.   |. . .      .||     ...  .. .||  ..|  .    . . |.         .| |      .|.||.||| ... |
flkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfeta

MMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEA
 .   .|.. ||.   .  .|  |   ||  ||.|...  | | 
hlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaeh
subfamily_PTPRN_pd Subfamily PTPRN 460-569 5.7e-20 66.2 In-house 180-289 (297) alignment 
Range on Protein: 460-569
Range on HMM: 180-289/297.0
NPKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKhLDRPVVVHCSDGVGRTGAFCTLFATLERVKlEGV--LDVFITARMLRTQRPGMVSH
| .| | | .. | .| |.|..||..  .....   ..|. |     |.|||||||.||||... .   |.|..  ||  .|.  |   || ||||.|  
nlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG.rscpivvhcsdGaGrtGvyilidlvlnrll.kGvkeidiaatlehlrdqrpglvkt

LDQYRLCYEAIL
 ||..... |. 
kdqfefaltava
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 328-574 8.4e-20 65.7 In-house 27-278 (312) alignment 
Range on Protein: 328-574
Range on HMM: 27-278/312.0
AVPDELSDFYTATQPKNSKKNRYPNILPCERCRVVLPAipdkEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEPL--
|| . .||   ..  |    ||||||   .| |  |      ..  || | ..        |..||.||.||.  ||...      .|..|||. |    
avgnivsdsectaflkfkdlnrypniqcwdrgrftlag....denfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgse

--EVFFS-----------AIYTYLCW--WGGGRWTLKKTNGVIVSEINfnpKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARrkhldRPVVV
    . |            .||  |     ||.   | |  |.   ..    ||.  .. |. .  | .| .|    |   |.  ..| .     .||. 
kcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvk...atgqesklnhyqwaswpdhgmpdscdtalrllsavkkdk.....kpvia

HCSDGVGRTGAFC---TLFATLERVKLEGVLDVFItarMLRTQRPGMVSHLDQYRLCYEAILAYLDS
||| ||||||...   .. |.|   . . | |.|.   .|| .|   |  . ||  .  ..| .| |
hcsagvgrtgtlaliesmiaalrhprkqnvkdsfv...llrkdrarsvrvfpqyvyalrcvleflys
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 28-284 1.7e-19 64.4 In-house 27-282 (302) alignment 
Range on Protein: 28-284
Range on HMM: 27-282/302.0
LFEKEYKDIKEPvNVTTRHCDNLI-NKPKNRYGNIKAYDHSRVILSsvqgdSESTDYINANWIDGFKQEKKYIATIGPKAETT---SDFWRMMWEHKSSI
  .||.| |..   | . .|     |  ||.  .....|. .|.|.      |  .|.||  ..  . ... | .  || ...    .||||....|   
evkkefkkidtm.kvdlekCkafkknlkknqsedvpildsnlvkle.....aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivs

VVMLTKLVEKGKvKCHKYWP---EENEQYGEIIVTLEEKEELADFEiRKFFLRKLSNQM-ETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVrNSWEGPQ
||.| .  |  |   ....|   .. ..||.. |     |.  . .  .. .  | . . .. ...   .| |... ||.  . | .  . |    . . 
vvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv.fakkika

SGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALL
. .. .    |.|| |.|..  . .|......   .   |  ||.||  .|.  .|| ... |||
dentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiall
subfamily_PTPN14_pd Subfamily PTPN14 462-573 1.7e-19 65.0 In-house 178-297 (300) alignment 
Range on Protein: 462-573
Range on HMM: 178-297/300.0
KTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKHL--------DRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPG
 ..| |.. |. | .|..| ||  . . .. . ..|  |||          . ||.||||.||||||   .    .. .. . ..|.  . ..||.||  
pskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrml

MVSHLDQYRLCYEAILAYLD
.|. | ||.  |.... ||.
lvqtlaqYkfvYkvlikylk
0048179 (Phosphotyrosine protein) phosphatases II 454-566 3.5e-19 64.4 In-house 34-139 (144) alignment 
Range on Protein: 454-566
Range on HMM: 34-139/144.0
VSEINFNPKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKHldRPVVVHCSDGVGRTGAFCTLFatleRVKLEGvLDVFITARMLRTQRPG
.. ..  ... . |.. ....| |  | ||. |  .....  ...|....  .||.|||| ||||||......    ..|..| |... . ...|..|||
inlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg..gpvlVHCsaGvgRtgtlvaay....lmkklg.lsleealalvrsrrpg

MVSHLDQYRLCYE
.| . .|.| ..|
avpnpgqlrfLle
subfamily_PTPRN_pd Subfamily PTPRN 318-423 3.8e-19 63.5 In-house 31-136 (297) alignment 
Range on Protein: 318-423
Range on HMM: 31-136/297.0
LEREFQLLNGAVPDElSDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQ-EKVAFIATQAPLDNTIEDFWRMVWHEEVFCIV
||.|.. |     .. |   .| ..|| ||||. ..|| .  || | .  ..|.. ||||| .   .  . |.||||.|| .|. |||.|||.. |  ||
lekewealcayeaep.stkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvviv

MLCGLNE
.|. |.|
nltrlee
subfamily_PTPN13_pd Subfamily PTPN13 338-419 8.2e-19 62.9 In-house 31-109 (273) alignment 
Range on Protein: 338-419
Range on HMM: 31-109/273.0
TATQPKNSKKNRYPNILPCERCRVVLpaipdKEDTTYINASYLEG--YQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLC
.. . .| .|||| |.||... || |     .....|||||...    ...  .||.| || .|..|||.|||  ..  |.|. 
vgkkkenkdknryrnvlPydetrvkl.....gdeggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvt
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 224-290 1.3e-18 61.1 In-house 2-68 (69) alignment 
Range on Protein: 224-290
Range on HMM: 2-68/69.0
TVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFG
 ||||.| ||||||| |   | .|| | |.|..  |  .|  |  ||    .| ||| || ||. .|
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 225-290 1.8e-18 60.6 In-house 2-67 (69) alignment 
Range on Protein: 225-290
Range on HMM: 2-67/69.0
VHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFG
||||.| ||||||| |   | .|| | |.|..  |  .|  |  ||    .| ||| || ||. .|
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG
subfamily_PTPN1_pd Subfamily PTPN1 328-421 4.3e-18 60.0 In-house 14-105 (290) alignment 
Range on Protein: 328-421
Range on HMM: 14-105/290.0
AVPDELSDFY--TATQPKNSKKNRYPNILPCERCRVVLpaipDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGL
 . .| |||   .| .|.| ..||| .. | . .|..|    ...|. ||||| .|  . |  .| || || ||.. ||.|||...  ..|||  .
dirkeasdfptreaklpenrnlnryrdvspydhsrikl....eradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkv
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 343-424 4.8e-18 60.2 In-house 2-82 (237) alignment 
Range on Protein: 343-424
Range on HMM: 2-82/237.0
KNSKKNRYPNILPCERCRVVLPAIPDKedTTYINASYLEGYQEK-VAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEP
.|  |||| ||   . .||||     .  . ||||.||.|..     .||.| ||... .|||.||| |    |||| || | 
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltglieg
subfamily_egg_pd Subfamily egg 315-424 8.4e-18 59.1 In-house 13-120 (307) alignment 
Range on Protein: 315-424
Range on HMM: 13-120/307.0
MTGLEREFQLLNGAVPDElsDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFC
. .||| ...|. .| ..   . || .  | .| | . .   . .|| |     .    .| | ...|      || .|||| || .||||||. |||  
vqelerrlevleesvdei..slttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqy

IVMLCGLNEP
||||    |.
ivmltsrkes
subfamily_eak_pd Subfamily eak 51-202 1.7e-17 57.8 In-house 51-199 (332) alignment 
Range on Protein: 51-202
Range on HMM: 51-199/332.0
INKPKNRYGnIKAYDHSRVILSSVQGDseSTDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEEN---E
 .  .| .. |  ||.  | |.| | .     ||||  ..  .  .||| |  .. .    ||.|. | ||  .|.| . ||..  |  ||.|..     
eavnrnvvk.ivpydrylvrltssqln..rlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreel

QYGEIIVTLEEKEELADFEIRKFFLRKlsnQMETRMVKHFYFTSWPDHDVPEYAT
..| . |.  |  . . .| |.. |.|     ||  |.|. .  | . ..| |  
kfGildverkefvkrniletrllelsk...GnethrvlhykvfGwtettlpkyed
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 343-571 2.7e-17 57.9 In-house 18-258 (290) alignment 
Range on Protein: 343-571
Range on HMM: 18-258/290.0
KNSKKNRYPNILpCERCRVVLPAIPDKEDTTYINASYLEgYQEKVAFIATQAPLDN-------TIEDFWRMVWHEEVFCIVMLCGLNEPLEVFFS-AIYT
|.....|... |  |  ||||     .    || |...  . . ...|.||.|. .       |||.|| |.  |.|  .||||  .|. .   . |   
khemdqRlevpL.veatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCak

YLCWWGGGRWTLK----------KTNGVIVSEINFNPKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKArrkhlDRPVVVHCSDGVGRTGAFCT
|     |.  ..|          | ..|.. |.  .   .|  .. | .. .|..  |. . .|...||  ...      . ||.||| ||. |  |. .
YvpesvgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkas.....ktpvivHcvdGiSrsAalaa

LFATLERVK-LEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAY
.      .  ..| . .     .|| ||  ....  ..     .|. .
iilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivll
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 343-423 3.2e-17 57.3 In-house 46-140 (350) alignment 
Range on Protein: 343-423
Range on HMM: 46-140/350.0
KNSKKNRYPNILPCERCRVVLPAIPD--------KEDTTYINASYLEGY----QEKVAF--IATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNE
.   |||| |||| |. || |.  .          .   ||||.||.      . .  |  ||||||| .|..||.... . .|  |..|  . |
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdve
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 7-102 7.4e-17 55.3 In-house 3-94 (95) alignment 
Range on Protein: 7-102
Range on HMM: 3-94/95.0
QPIPVAELKQHYLRMHANSDLLFEKEYKDIKEPVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQgDSestDYINANWIDGFKQEKKYIATI
.|| |. .. | | ||.|||  |..|.| |      .        | ||||. ||  || .||.|.. . ||   ||||| ..||. . . |||. 
kpihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttkr.ds...dyinacfvdgyarkncyiaaq
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 54-158 8.1e-17 55.6 In-house 50-167 (349) alignment 
Range on Protein: 54-158
Range on HMM: 50-167/349.0
PKNRYGNIKAYDHSRVILSS------VQGDSES-------TDYINANWID--GFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKC
 |||| .|  |.||||.|        |   |.|        ||||||..    .. |||||||  |   |  ||....   .  .|. |..  |..  ||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

HKYWPEENeqYGEIIVTLEE
..|| | .  | .| | | .
diywqels..ysnitvklqn
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 312-423 1.2e-16 55.6 In-house 12-118 (307) alignment 
Range on Protein: 312-423
Range on HMM: 12-118/307.0
GTGMTGLEREFQLLNGAVPDELSdfyTATQPKNSKKNRYPNILPCERCRVVLPAipDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEE
  |.. |  ||. |    |. ..   . .   |..|||| ..   ...|.|.    |   . || | ||    .   ||..| ||.||. .|| |.  |.
dkgvqalvdefrvlakktpegvt...veafsantdknryqdvkcqdkgrivvkf..dglasdyihanylgiaikpkkficaqgplentqysfwamaiqek

VFCIVMLCGLNE
| ...||| . |
vesvimlckvie
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 335-423 1.5e-16 55.2 In-house 24-112 (297) alignment 
Range on Protein: 335-423
Range on HMM: 24-112/297.0
DFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDttYINASYLEGYQE--KVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNE
.| .| ..   .|||| .||  .  || |   . ..|  |||| |.   .|  .. .| .| ||..|..|||..|....|  |||.. |.|
sfssakrnsslrknryrdilatddtrvkllrviterd..yinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqe
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 463-573 2.8e-16 54.2 In-house 164-278 (287) alignment 
Range on Protein: 463-573
Range on HMM: 164-278/287.0
TGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDL----QKARRKHLDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHL
| | | .  . .|.| .....   . .| .. |     . ||      |.|||.. |.||.| . .... ..| .  | .||  .   || .| ..|   
trearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqav

DQYRLCYEAILAYLD
 |.|| |||. .|  
vqlrllyealvtyyk
subfamily_PTPN1_pd Subfamily PTPN1 460-570 3.7e-16 53.7 In-house 155-269 (290) alignment 
Range on Protein: 460-570
Range on HMM: 155-269/290.0
NPKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKHLD-RPVVVHCSDGVGRTGAFCTLFATLERVKLEGV---LDVFITARMLRTQRPGMV
| || | |.|.|| |. |.. .||    . .... .....     |  |.|.||| |.||.|.|| . . | ... ..    .|.  .   || .| |..
nlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGli

SHLDQYRLCYEAILA
   || |. | ||| 
qtadqlrfsylaile
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 314-421 7.6e-15 49.3 In-house 25-128 (310) alignment 
Range on Protein: 314-421
Range on HMM: 25-128/310.0
GMTGLEREFQLLNGAVpDeLSDFYTATQpKNSKKNRYPNILPCERCRVVLpAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVF
|. || .... |.    |  |  | | . |. .|||| ...  . .|| |  |       || | |.     . .|| .| ||. || |||||.. |   
gieglvkqyrkldakq.d.ssltyeayk.kymhknrysdvvcldtsrvkl.kidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqerae

CIVMLCGL
 |..||  
silllckv
subfamily_CG42327_pd Subfamily CG42327 219-283 1.1e-14 48.9 In-house 246-311 (319) alignment 
Range on Protein: 219-283
Range on HMM: 246-311/319.0
QSGPITVHCSAGVGRTGTFIVIDAMMEQIKEE-NLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYAL
. ||..|||| ||||||. |  |  .....|  . .|.   || .| .|   |.   || ||.  |
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvl
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 302-423 8.9e-14 45.9 In-house 8-124 (305) alignment 
Range on Protein: 302-423
Range on HMM: 8-124/305.0
RLMQLAEKVAGTGMTGLEREFQLLNGAvpDELSDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEdttYINASYLEGYQEKVAFIATQAPLDNTIE
..... ...   | .||  ||. ..    ...  . .  . ....|||| ..   .. || | .   .|   || | |.    .   || |||||..|  
qilkfvkrtlekgpaglraefvamkrf..ndfekmkafkeaqeagknrykdvgcldnnrvklegpwphe...yihanyvstptnpkrfictqaplektca

DFWRMVWHEEVFCIVMLCGLNE
||| | . . |  | ||| | |
dfwymclqdkveaifmlcnlle
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 217-286 1.3e-13 45.5 In-house 225-294 (297) alignment 
Range on Protein: 217-286
Range on HMM: 225-294/297.0
GPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEA
 |.. .. |||||||||.|  .  |....... . . || . .| .| ||  .||   |. ... | |. 
mprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkk
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 309-422 1.7e-13 44.9 In-house 17-131 (305) alignment 
Range on Protein: 309-422
Range on HMM: 17-131/305.0
KVAGTGMTGLEREFQLL-NGAVPDELSDFYTATQPKN--SKKNRYPNIlPCERCRVVLPAIPDkeDTTYINASYLEGY-QEKVAFIATQAPLDNTIEDFW
.    |.  |  ||. | . . ||     . | |  .    |||| .. ||.   .|. . |    . || | |.      .  ||..| |||.||..||
raldvgvdklreefrglakytrpdmtqvafnanqsadiaitknryqdv.pcqdqsavkldkps..psdyihanyvgcpmipekrficaqgpldqtidefw

RMVWHEEVFCIVMLCGLN
 || .. |  |||||   
wmviqnkveqivmlcktv
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 184-284 4.7e-13 43.6 In-house 217-341 (350) alignment 
Range on Protein: 184-284
Range on HMM: 217-341/350.0
VKHFYFTSWPDH---DVPEYATGLLEF------WKRVRNSWEGPQSGPITVHCSAGVGRTGTFIVIDAMME------QIKE-EN-------LLDV-YSYV
| ....  |.|      ||     ||           ..  .  .| || ||||||||||||.. .| ...      ....  .       . |.    |
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

SRIRAQRNFMVQRPSQYSFIHYALL
 ..| ||  |||   |. ||. |||
nelrkqrismvqnldqfifiYeall
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 463-569 1.9e-12 41.9 In-house 129-236 (237) alignment 
Range on Protein: 463-569
Range on HMM: 129-236/237.0
TGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKA-RRKHLDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQY
  ||| |  . .  | .. || .  ... .  .. .  .      | ..||| |||||| |  . | | . | . |.|..     .  .|| ..   |||
lkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqy

RLCYEAIL
 . ...||
vfihqtil
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 50-137 3e-12 40.6 In-house 32-117 (332) alignment 
Range on Protein: 50-137
Range on HMM: 32-117/332.0
LINKPKNRYGNIKAYDHSRVILSSVQGDsesTDYINANWIDGFKQEKKYIATIGPKAETT-SDFWRMMWEHKSSIVVMLTKLVEKGKVK
| |   ||   . ..||||| |.  .|     |. ||.|.||. ..  || .  |  . |   ||||. |.| |.....  . || | |
lnnmdmnriphlycfdhsrvelapqdgk...ddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 469-572 3e-12 40.9 In-house 217-344 (350) alignment 
Range on Protein: 469-572
Range on HMM: 217-344/350.0
ISHFMYLEWTEH---AVPTKLLTIID----LIGDLQKARRKHL--DRPVVVHCSDGVGRTGAFCTLFATLE-----------RVKLEG---VLD-VFITA
. .. .  | .      | ..|....    || ||      .     |..|||| |||||| ..||   |.            .||.    . | ..|. 
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

RMLRTQRPGMVSHLDQYRLCYEAILAYL
  || ||  ||  |||.  .|||.| | 
nelrkqrismvqnldqfifiYeallfyf
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 505-572 3.6e-12 40.7 In-house 228-295 (297) alignment 
Range on Protein: 505-572
Range on HMM: 228-295/297.0
DRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYL
. ...|||| ||||.|      . |.... . . ||    ..|| ||. .|  |.|. |.|.|.|. |
nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 463-577 1.3e-11 39.1 In-house 172-282 (307) alignment 
Range on Protein: 463-577
Range on HMM: 172-282/307.0
TGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKArrkhlDRPVVVHCSDGVGRTGAFCTLFATLER-VKLEGVLDVFITARMLRTQRPGMVSHLDQY
... | |.|. . .| .. ||   || |.|.   .         ||||||| ||||.|.  ..    .. .. .   |.    . ||.||.  .    ||
aqksrtiqhlqwenwpdrgvpqinltainlleavryd.....tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqy

RLCYEAILAYLDSFEE
   .  .| |.     
lylhrvlleyflelyk
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 335-424 1.4e-11 38.5 In-house 87-174 (244) alignment 
Range on Protein: 335-424
Range on HMM: 87-174/244.0
DFYTATQPKNSKKNRYPNILPCERCRVVLPAipDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEP
 .  | .|.|| |||    || .  || |         ||||||..        .| || || .|  |||.|.    |  .|.|  ..| 
vmkdafnpnnswknregaglpfdfnrvplsk..gsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 509-569 2.9e-11 37.6 In-house 2-62 (69) alignment 
Range on Protein: 509-569
Range on HMM: 2-62/69.0
VVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAIL
||||| | ||||.| ...  . |.| | ..|.|   . .|  || ||    .| . ..|. 
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalv
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 509-569 3.7e-11 37.2 In-house 1-61 (69) alignment 
Range on Protein: 509-569
Range on HMM: 1-61/69.0
VVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAIL
||||| | ||||.| ..   . |.| | ..|.|   . .|  || ||   ..| . ..|. 
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalv
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 456-572 4.1e-11 37.2 In-house 175-287 (305) alignment 
Range on Protein: 456-572
Range on HMM: 175-287/305.0
EINFNPKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLigdLQKARRkhLDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVL-DVFITARMLRTQRPGM
..  .   ...|...|. . .| .  ||.  |.|..|   |.|||   .  |.||||| |.||||.   |   |...    .. |     . .| ||   
vlviegpgekarkvthyhwidwpdrgvpaadlailel...lekarp..skgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnns

VSHLDQYRLCYEAILAYL
.   .|| . .. || |.
iqtdaqylfvhqvilnyf
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 391-549 4.2e-11 37.4 In-house 39-178 (255) alignment 
Range on Protein: 391-549
Range on HMM: 39-178/255.0
AtqapldnTIEDFWRMVWHEEVFCIVMLCGLNEPLE----VFFSA-IYTYLCWWGGGRWTLKKTNGVIVSEINFNPKTG---EVRQISHFMYLEWTEHAV
        |.. |....   .   .|||| ..|        .|       | .      | | .. |..  ..   . |   . ... |..|  | |.  
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWiekna

PTKLLTIIDLIgdlqKARRKHldRPVVVHCSDGVGRTGAFCtlfatlervklegvLDVFITARMLRT
|     |  ..    |. |.   ..|||||| |.||. ||               |  ..  .|.|.
Pelareilnil....kvvrds..ksvvvhCstGiGrsaafv..............laelvyqkmirs
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 476-572 6.5e-11 36.2 In-house 190-285 (302) alignment 
Range on Protein: 476-572
Range on HMM: 190-285/302.0
EWTEHAVPTKLLTIIDLIGDLqKARRKHLDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYL
 | .. ||.|  ..|  . ..  |.  . | ..|.    |.|| ||| ||....|... .    .  ... .|.||| .|  |.||   | |.| |.
nWkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 70-194 6.6e-11 36.6 In-house 11-123 (130) alignment 
Range on Protein: 70-194
Range on HMM: 11-123/130.0
IlssvqgdseSTDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKgkvkcHKYWPEEN--EQY-GEIIVTLEEKEELADfe
            .||||...    . ..|. |  | |.|. |||.|| |    ..|.|  . |.      .|||. .  | |  .||||| ...|     
q.........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdrdefkn..

IRKFFLRKLSNQME-TRMVKHFYFTSWPD
|.  .|.  |. .|  . .  |  . || 
ikasnleiesdlneshqaltmfqisnwps
subfamily_PTEN_pd Subfamily PTEN 181-281 1.3e-10 36.5 In-house 79-174 (184) alignment 
Range on Protein: 181-281
Range on HMM: 79-174/184.0
TRMVKHFYFTswpDHDVPEYATgLLEFWKRVRNSWEGPQSGPITVHCSAGVGRTGTFIVIdAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIH
. .|... |.   ||  |.    | |. . ...  |  ..  . ||| || ||||. ||   .... . |.  .. .. ...|.. .  |. |||  ...
dgrvavypfd...Dhnppplel.leeivediekwleedkknvvvvHCkaGkGRtGvliva.yllkslllekaeealelfaeaRtknkkgvtiPsqrRYve

Y
|
Y
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 343-419 1.8e-10 34.7 In-house 47-139 (349) alignment 
Range on Protein: 343-419
Range on HMM: 47-139/349.0
KNSKKNRYPNILPCERCRVVLPAIPDKED--------------TTYINASYLEGYQE--KVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLC
.   |||| .||| |  ||.|.  .                    |||| ||.  .   .  .|||||||  |..||....  ..|  .. | 
elfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLn
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 502-572 1.8e-10 34.7 In-house 258-344 (349) alignment 
Range on Protein: 502-572
Range on HMM: 258-344/349.0
KHLD----RPVVVHCSDGVGRTGAFCTLFATLE----------RVKLEGVL--DVFITARMLRTQRPGMVSHLDQYRLCYEAILAYL
..||     ...|||| | |||| ..||   |.          ..||. .|   ..|.   || ||  ||  | |.  .|||.| |.
lyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 7-93 2.6e-10 34.2 In-house 4-87 (440) alignment 
Range on Protein: 7-93
Range on HMM: 4-87/440.0
QPIPVAELKQhYLRMHANSDlLFEKEYKDIKEPVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDSeSTDYINANWIDGFK
.|| ||.. . |..    |   || |.  .   .   .  .    || |||| || |||||||.|  |.|   ..||||| .|.| .
rpiivadfad.yvqnnrrsr.afedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvp.dsdyinasyingie
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 321-419 3.1e-10 34.2 In-house 27-115 (303) alignment 
Range on Protein: 321-419
Range on HMM: 27-115/303.0
EFQLLNGAVPDELSDFytaTQPKNSKKNRYPNILPCERCRVVLpaipdkEDTTYINASYLEGYQEKVAfIATQAPLDNTIEDFWRMVWHEEVFCIVMLC
||. . . .| ..|        || .|||. ...  .  .| |       |..|| |||||   .| | | || ||  |  |||.|. .. | |...| 
efekvvsylppsvskn...qfvknmdknrfvdvicldhskvkl......sdssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvllll
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 340-418 6.1e-10 33.1 In-house 33-116 (347) alignment 
Range on Protein: 340-418
Range on HMM: 33-116/347.0
TQPKNSKKNRYPNILPCERCRVVLPAI-----PDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVML
   |. .|||  .    .  ||||        .  .  ||||||..   . .  .| || || .|. |||.||    |  .| .
ewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 38-127 1.2e-09 32.1 In-house 25-116 (347) alignment 
Range on Protein: 38-127
Range on HMM: 25-116/347.0
EPVNVTTRHCDNLINkpKNRYGNIKAYDHSRVILSSVQGDSESTD----YINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVML
 | ..|.   .. ..  |||  . |  | .||.||  . .   .|    ||||  |   . .|.|| |  |  .|  |||.|.   | . || .
spskftsveweksls..knrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_ptpA1_pd Subfamily ptpA1 463-529 1.6e-09 32.0 In-house 182-253 (418) alignment 
Range on Protein: 463-529
Range on HMM: 182-253/418.0
TGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKAR---RKHLDR--PVVVHCSDGVGRTGAFCTLFATL
 || |.|... |  | .| .| .   . .|.  . . .       ||  |..|||| ||||||.|||    .
egetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimm
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 212-285 1.8e-09 31.4 In-house 257-342 (349) alignment 
Range on Protein: 212-285
Range on HMM: 257-342/349.0
RNSWEGPQSGPITVHCSAGVGRTGTFIVIDAMME----QIKEENLLDVYS--------YVSRIRAQRNFMVQRPSQYSFIHYALLE
|. ..  |. .. |||||| ||||... .| ...      .| | ... .         |  .| ||  |||  .|. .|. |||.
rlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLk
0038934 (Phosphotyrosine protein) phosphatases II 186-276 2.1e-09 32.8 In-house 81-166 (194) alignment 
Range on Protein: 186-276
Range on HMM: 81-166/194.0
HFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGPQSGPITVHCSAGVGRTGTFIVIdAMMEQIKEeNLLDVYSYVSRIRaqrNFMVQRPSQY
...   .||. ..     ||.| . |    .  ..| . ||| ||.|||||...  ....  .  .. . . .....|   . ........
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa.YLiyrlgm.saeeAialfrekR...pgaipnqdyl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 454-572 2.5e-09 31.2 In-house 175-289 (305) alignment 
Range on Protein: 454-572
Range on HMM: 175-289/305.0
VSEINFNPKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARrkhldRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVL-DVFITARMLRTQRP
.. .|..   ..   . |. . || .  ||   || ..|.  .. ..      |.||||| |.||||.  ..   ||..  .     .    . || || 
itllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk.....vpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqra

GMVSHLDQYRLCYEAILAYL
  .    ||   .  .| |.
fsiqndvqylfihrvmlnyf
subfamily_hpo-7_pd Subfamily hpo-7 391-524 3.8e-09 30.8 In-house 42-173 (263) alignment 
Range on Protein: 391-524
Range on HMM: 42-173/263.0
AtqapLDNTIEDFWRMVWHEEVFCIVMLCGLNEP----------LEVFFSAIYT--YLCWWGGGRWTLKKTNgVIVSEINFnpkTGEVRQISHFMYLEWT
     | .||. |....   .   .||||  ||           ||     ...   .|       .|.||. ...| ..      ..... |..|  | 
l....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktl.ellstlge...KkkthtvkhysykgWi

EHAVPTKLLTIIDLIgdlqKARRKHldRPVVVHCSDGVGRTGAFCT
|.  |..   |. ..    |. |.   ...||||| |.||. ||  
ekndpelareilnil....kvarns..kslvvhcstGiGrsaafsv
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 344-420 5.2e-09 30.0 In-house 34-109 (332) alignment 
Range on Protein: 344-420
Range on HMM: 34-109/332.0
NSKKNRYPNILPCERCRVVLPAIPDKEDttYINASYLEGYQEKVAFIATQAPLDNTIE-DFWRMVWHEEVFCIVMLCG
|   || | .   .. || |     |.|  . |||...|| .| |.| .|||...  |  |||||   .   |...  
nmdmnriphlycfdhsrvelapqdgkdd..fynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgd
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 338-393 5.5e-09 30.1 In-house 41-94 (95) alignment 
Range on Protein: 338-393
Range on HMM: 41-94/95.0
TA-TQPKNSKKNRYPNILPCERCRVVLPAipdKEDTTYINASYLEGYQEKVAFIATQ
|. .   |  |||. ||.| .  |||| .   | |. |||| ...||  | ..||.|
tvgsseanipknrflnifpydatrvvltt...krdsdyinacfvdgyarkncyiaaq
subfamily_CG42327_pd Subfamily CG42327 503-571 5.6e-09 30.1 In-house 245-314 (319) alignment 
Range on Protein: 503-571
Range on HMM: 245-314/319.0
HLDRPVVVHCSDGVGRTGAFCTLFATLERVKLE-GVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAY
.   |.||||||||||||   .   ......     .|.  .   .| .|   |   .|| . |  .  |
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_eak_pd Subfamily eak 217-305 1e-08 29.0 In-house 234-321 (332) alignment 
Range on Protein: 217-305
Range on HMM: 234-321/332.0
GPQSGPItVHCSAGVGRTGTFIVIDAMMEQI--KEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTeiEVQNLRMRLMQ
 |   || . .. |  |.|.|.||| ... |  | .||  |  .. ... .|.  |    |.|||. ..|. .   .   ....|.  |. 
ppsfapi.iqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnn..rlrdlkkylea
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 97-193 2.4e-08 27.9 In-house 138-231 (244) alignment 
Range on Protein: 97-193
Range on HMM: 138-231/244.0
KYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKgkvkcHKYWPEE--NEQYGE-IIVTLEEKEELADFEIRKFFLRKLSNQMEtRMVKHFYFTSWP
.|| |  | |.|. |||.|| | .  ..|.|  . |.      .|||.    | | | | ||| ...|. .    .. .    |.   . .  |  . ||
eyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdseplewyeeditvtltdrdefknikasnleiesdmnesh.qaltmfqisnwp
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 33-148 3.9e-08 26.4 In-house 5-90 (169) alignment 
Range on Protein: 33-148
Range on HMM: 5-90/169.0
YKDIKEP---VNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDSEStDYINAnwidgfkqekkyiatigpkaettsdfwRMMWEHKSSIVVMLTK
|...||    ..     ..  .|. |||     |  | || |  |  |  | |||||                           ||.||  .|..|.|  
ynelkefmktieynnfmaeltcnetknrpagplapshtrvklqrvmedlgs.dyina...........................rmiwetnasvivvlgd

LVEKgkvkcHKYWPEENEQ
  .|       .||| .. 
tddk.....nnfwpekedy
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 40-147 7.5e-08 25.4 In-house 14-88 (169) alignment 
Range on Protein: 40-147
Range on HMM: 14-88/169.0
VNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDSEStDYINAnwidgfkqekkyiatigpkaettsdfwRMMWEHKSSIVVMLTKLVEKgkvkcH
..     ..  .|. |||     |  | || |  |  |  | |||||                           ||.||  .|..|.|    .|      
ieynnfmaeltcnetknrpagplapshtrvklqrvmedlgs.dyina...........................rmiwetnasvivvlGdtddk.....n

KYWPEENE
 .||| ..
nfwpeked
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 137-280 1.2e-07 25.5 In-house 149-295 (332) alignment 
Range on Protein: 137-280
Range on HMM: 149-295/332.0
KCHKYWPEENEQYGEIIVTLEEKEELADFEIRKFFLRKLSNQMETRMV-KHFYftSWPDH-DVPEYATGLLEFWK--RVRNSW-EGPQSGPITVHCSAGV
 |.|.|||.. .     ....  .. ..  .. | |    .. . . |  |||   | |   .|||   .    |   .|.|   |   ||| . |..||
icrkfwpekrskkdfpalsiqasddhsethmktfnltvtekkqdhqtvlmhfy..ewadasklpeymldmrasiklqyirsskktgvcigpimlvcatgv

GRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIH
 .   .  || .. .| ||  . .   .| |. ||   ..    ||   
ekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpystac
subfamily_VSP_pd Subfamily VSP 193-282 1.2e-07 25.8 In-house 102-194 (212) alignment 
Range on Protein: 193-282
Range on HMM: 102-194/212.0
PDHDVPEYAtGLLEFWKRVRNSWEGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKE--ENLLDVYSY--VSRIRAQRNFMVQRPSQYSFIHYA
 ||.||.    || | |.|..  |  ..  ...||  | ||||| .    .. .| |  .. || ..     . ....   || |||. ...| 
ddhnvpkle.ellvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgyl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 90-162 2.5e-07 24.4 In-house 230-301 (440) alignment 
Range on Protein: 90-162
Range on HMM: 230-301/440.0
DGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKgkvKCHKYWPEENE--QYGEIIVTLEEKEEL
.|. . . .|||  |   |  ||||.. ... | ..|| .| .|    |  ||| .     .| . |     |..
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpftvghkgsenm
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 343-428 3e-07 24.2 In-house 50-137 (302) alignment 
Range on Protein: 343-428
Range on HMM: 50-137/302.0
KNSKKNRYPNILPCERCRVVLPAIPDKedttYINASYLEGYQEKVAFIATQAPLDNTI---EDFWRMVWHEEVFCIVMLCGLNEP---LEVF
||.|||. ...   .  .| |.| ||.    |.||| .|  . .   | .| |  ..    |.|||||..|..  .|.| | .|    |. .
knlkknqsedvpildsnlvkleaepds....yvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlsel
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 445-557 3.1e-07 24.1 In-house 165-273 (302) alignment 
Range on Protein: 445-557
Range on HMM: 165-273/302.0
TLKKTNGVIVSEINFNPKTGEVR-QISHFMYLEWTEHAVPTKLLTIIDLIGDLQKarrkhLDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFIT
| ||.  .   ||. . |. .|.  .. ...  | .|  | .  | .|..   .        . |.|||| ||||||.. ..   ..  . . | |.   
tdkksfklytveiknekkkkkvkktvdilafsawpdhGapkeaytaldilkfces.....ykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsi

ARMLRTQRPGMVSH
   .|. | | | .
vlpvrqcryGavqd
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 52-93 3.3e-07 24.2 In-house 39-78 (244) alignment 
Range on Protein: 52-93
Range on HMM: 39-78/244.0
NKPKNRYGNIKAYDHSRVILSSVQgdSESTDYINANWIDGFK
|  |||| ||  .|..|||||| .   |..||||||.|.| .
natknryinilpfdetrvilsssk..kegsdyinanyiqgsq
subfamily_PTPDC1_pd Subfamily PTPDC1 186-279 3.6e-07 24.8 In-house 84-168 (182) alignment 
Range on Protein: 186-279
Range on HMM: 84-168/182.0
HFYFTSWPDHDVPEYaTGLLEFWKRVRNSWegpQSGPITVHCSAGVGRTGTFIVIDAMMEQikEenlLDVYSYVSRIRAQRNFMVQRPSQYSFI
 .|  .|.|..|.   . .|.  | |  .    | | ..||| || ||||  |    .  .  .   |.    .. .|..|   .|  .|  ..
yvynfgwkDygvasl.eriLdivkvvafal...qegkvavhChaGlGrtGvliacylvyak..r...ltaekaiklvrskrpksiqtreqvelv
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 370-425 5.1e-07 24.1 In-house 11-66 (130) alignment 
Range on Protein: 370-425
Range on HMM: 11-66/130.0
EDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEPL
.. ||||||..   .    .. ||.|| .|  |||.|. .  |  .|.|  ..|  
qgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed
0038934 (Phosphotyrosine protein) phosphatases II 473-566 5.6e-07 24.9 In-house 83-171 (194) alignment 
Range on Protein: 473-566
Range on HMM: 83-171/194.0
MYLEWTEHAVPTKLLTIIDLIGDLQKARRKHLDRPVVVHCSDGVGRTGAFCTLFATL-ERVKLEGVLDvfitarMLRTQRPGMVSHLDQYRLCYE
. | . .. ..  | .. . .  ...  ... .  |.|||  |.|||| ..  .     . ..|  ..      ..|  |||.. . |...  ..
lklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAia......lfrekRpgaipnqdyleallk
PTEN_1 191-281 6.5e-07 24.3 In-house 101-187 (196) alignment 
Range on Protein: 191-281
Range on HMM: 101-187/196.0
SWPDHDVPEYAtGLLEFWKRVRNSWE-GPQSGPITVHCSAGVGRTGTFIViDAMMEQIKeENLLDVYSYVSRIRAQRNFMvqRPSQYSFIHY
...|| .|  .  |... |.. ...   |. . . ||| ||.||.|| .    .|.  |  .  .  ..| . | ....    |||  ...|
pieDhgapsls.elfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva.ayLmykgk.ltadeAlelvrekRppgapn..spsqerlley
PTPc_motif_SM00404 218-264 6.5e-07 24.3 In-house 78-122 (140) alignment 
Range on Protein: 218-264
Range on HMM: 78-122/140.0
PQSGPITVHCSAGVGRTGTFIVIDAMMEQikEENLLDVYSYVSRIRA
 . | . ||| ||| |..|.|.   |...  . .| ..|..|.. | 
kkggkvlVHCqaGvSRSatliiaYlmryr..qlslaeayefvkerRp
subfamily_eak_pd Subfamily eak 346-484 7.6e-07 22.8 In-house 54-196 (332) alignment 
Range on Protein: 346-484
Range on HMM: 54-196/332.0
KKNrYPNILPCERCRVVLPAIpDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCG-LNEPLEVF---FSAIYTYlcWWGG
..|   .|.| .|  | | .   ..   ||||| .|  .    .| | .. .. .  ||.||  .   .||.|   ... || .   |         .  
nrn.vvkivpydrylvrltss.qlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktre..elkf

GRWTLKKTNG---VIVSEINFNPKTG-EVRQISHFMYLEWTEHAVPT
| . ... .     |.   ..  . | |  .. |. .  ||| ..| 
GildverkefvkrniletrllelskGnethrvlhykvfGwtettlpk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 338-382 1.9e-06 21.5 In-house 41-85 (440) alignment 
Range on Protein: 338-382
Range on HMM: 41-85/440.0
TATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEG
 |. |.|  |||| |||  ...||.|  .    |. ||||||..|
iaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasying
DSPc Dual specificity phosphatase, catalytic domain 219-265 3.8e-06 21.8 Pfam-A 72-116 (133) alignment 
Range on Protein: 219-265
Range on HMM: 72-116/133.0
QSGPITVHCSAGVGRTGTFIVIDAMMEqiKEENLLDVYSYVSRIRAQ
. . . ||| ||. |..|.|.   |..  |. .| . |..|.. | .
kgkkvlVHCqaGisRSatliiaYlmkt..knlslneAyefvkerrsk
DSPc Dual specificity phosphatase, catalytic domain 219-265 3.8e-06 21.8 In-house 72-116 (133) alignment 
Range on Protein: 219-265
Range on HMM: 72-116/133.0
QSGPITVHCSAGVGRTGTFIVIDAMMEqiKEENLLDVYSYVSRIRAQ
. . . ||| ||. |..|.|.   |..  |. .| . |..|.. | .
kgkkvlVHCqaGisRSatliiaYlmkt..knlslneAyefvkerrsk
PTEN_1 474-521 6.4e-06 21.1 In-house 99-146 (196) alignment 
Range on Protein: 474-521
Range on HMM: 99-146/196.0
YLEWTEHAVPTkLLTIIDLIGDLQKARRKHL-DRPVVVHCSDGVGRTGA
 .... | .|. |  ..| . ..  .....   . |.|||  |.||.| 
hfpieDhgaps.lselfdicksfiewllsdpngnvVlVHCkaGlgRsGt
subfamily_DSP10_pd Subfamily DSP10 222-264 9.8e-06 19.5 In-house 94-134 (159) alignment 
Range on Protein: 222-264
Range on HMM: 94-134/159.0
PITVHCSAGVGRTGTFiVIDAMMEQiKEENLLDVYSYVSRIRA
 . ||| ||. |  |. ||  .|.. .. .| | | .|.  |.
rvLvhCqaGisrsatv.viaYlmkh.lnlslndaykfvkekrp