Gene NvecPTP-sf5-1 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily NvecPTP-sf5
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP062_AA protein Get Run
NvecP062_AA_12-288 phosphatase_domain Get Run
NvecP062_AA_300-573 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 6-508 2.4e-256 846.8 In-house 2-502 (564) alignment
Range on Protein: 6-508
Range on HMM: 2-502/564.0
RQPIPVAELKQHYLRMHANSDLLFEKEYKDIKEPVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDsESTDYINANWIDGFKQEKKYIATIGPK
..||||||||.|. ...||||| ||.|||.|.|. ..|...... .||.|||| || |||||||.||.|.|| |..|||||..|||....|.||||.||.
skpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegd.egsDYINAsfidgyrkrkayIAtqgPl

AETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEE-NEQYGEIIVTLEEKEELADFEIRKFFLrKLSNQMETRMVKHFYFTSWPDHDVPEYATGL
|||..|||||.||..||..||||||.|||||||||||||. .|.|||..|||||.|||||.|||.|.| | ....|.|.|..|.|||||||.|||.||.|
aetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatsl

LEFWKRVRNSWeGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLRMRLM
|.....||...  |..|||.|||||||||||||||||||.|.||||...|.|.||...|.|||.|||...||.|||.|.|||...|.||.|..||...|.
Ldlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlq

QLAEKVAGTGMTGLEREFQLLNGAVPDELSDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFW
.|||....|.|||||.||| |..|...||..|..||.|||.||||..|||..|.|||||.||..||...||||||||.|.||.|||||||||.||.||||
kLaeveedtemtgleleFqrLatakeieleefavatkpknkkknrfsnilalescrvvlsairakeesdyinasyleayrekrafiatqaplkntvedfw

RMVWHEEVFCIVMLCGLNEPLEVFFSAIYTYLCWWGGGRWTLKKTNGVIVSEINFNPKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKHL
||||.|||..||||..|.|.||...|..|..|.....|..|.|.......|.|.|..|..||...|...||..|..||..||||.||...||.||.||.|
rmvweeevkiivmltkleekleeesseyysdleatkyGeitikvlkkkeksdilfrkkkvevkekseavyllhtvqavdkklltvidsvldllkavrkvl

DRPV
.|.|
erav

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 5-323 1.3e-169 558.3 In-house 1-319 (319) alignment
Range on Protein: 5-323
Range on HMM: 1-319/319.0
TRQPIPVAELKQHYLRMHANSDLLFEKEYKDIKEPVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGdSESTDYINANWIDGFKQEKKYIATIGP
....|.|.|||... ....... |.|||.|..||.||.|...... .||.|||| ||.|||..||.||...| .|..|||||..|||.....|.|||..|
gdteievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldg.vegsdyinasfidgyqerekfiatqaP

KAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEEN-EQYGEIIVTLEEKEELADFEIRKFFLRKLSNQMETRMVKHFYFTSWPDHDVPEYATG
...|..|||||.||..|||||||||||||.|||..||||||| |.||..||||||.|||.|..|||..|.|.|...|||.||||..|.||||||||.||.
lentiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekats

LLEFWKRVRNSWEGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLRMRL
||...||.|.|.|..|||||.|||||||||||||||.|||.|..|||..|||.|.|||.|.|||.|||||.||.||..||||||..||||||||.||.||
lldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrl

MQLAEKVAGTGMTGLEREFQ
.|||||||.||.||||||||
kqlaekvadtgetglerefq

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 318-582 8.9e-127 417.6 In-house 25-294 (319) alignment
Range on Protein: 318-582
Range on HMM: 25-294/319.0
LEREFQLLNGAVPDelsDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVM
||.||.||..||.|   .|..|....|.|||||.|||...|.||||......|...|||||...||||...||||||||.|||||||||||.||....||
lekefkllkeavnd...tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvm

LCGLNEPLEVFFSAIYTYLCWWGGGRWTL-----KKTNGVIVSEINFNPKTGEV--RQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKHLDRPVVV
|..|.|.|.|........ .....||...     ......|......|.|..||  |...||.|.||..|.||.|.....||.....|.|.|. ..|.||
ltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivv

HCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYLDSFE-ESQYQN
|||.||||||.|..|.|.|||||.|||||||.|...|||||. ||.. .||...|||.|....... | . |.
hCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqd

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 9-324 3.3e-113 372.9 In-house 2-317 (318) alignment
Range on Protein: 9-324
Range on HMM: 2-317/318.0
IPVAELKQHYLRMHANSDLLFEKEYKDI-KEPVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDSEStDYINANWIDGFKQEKKYIATIGPKAE
|.| .|..|  |.... .||...||. . ... .||. .  . .|| |||| || ||||.|| |. ..|. .| ||||||.|||....|.|||. .| .|
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegs.DyinanyidGyrrkkayiaaqaPlpe

TTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEEN-EQYGEIIVTLEEKEELADFEIRKFFLRKlSNQMETRMVKHFYFTSWPDHDVPEYATGLLE
| .|||||.|| .|...||||...|.||.|.|.|||... ..||.. |.|.|. ||.|. .|.| ... ... |.|.|. . .|||||..||| ...||.
tieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtr.teeeesrqvrqyhytsWpdegvpesgaslld

FWKRVRNSWEGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLRMRLMQL
. ..|..  . .. |||.|||||||||||.||..|...|.||.|.|.||. .|...| ||| |||  .|| ||. .||||.. ||||.. ..|| |. .|
lvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirel

AEKVAGTGMTGLEREFQL
 |. . .|.| .. ||| 
reqdpesgttemdaefqr

subfamily_PTPRB_pd Subfamily PTPRB 5-288 2.2e-104 343.6 In-house 3-286 (293) alignment
Range on Protein: 5-288
Range on HMM: 3-286/293.0
TRQPIPVAELKQHYLRMHANSDLLFEKEYKDIKEP-VNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDsESTDYINANWIDGFKQEKKYIATIG
. .|| . ....|. .|.|.||| | .||...|.   . ..   .. .|. |||| || .|||||| |...... ...||||||.|.|.......||| |
kskpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkde.sgsDYinanyipgynsprefiatqG

PKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEE--NEQYGEIIVTLEEKEELADFEIRKFFLRKlsnQMETRMVKHFYFTSWPDHDVPEYA
|  ||. |||||.||.||||.||||.|||||||||..|||..  . .||.| ||| ..||| |. ||.. ..|   ..|.| |... |||||||.||| .
PlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPekt

TGLLEFWKRVRNSW-EGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVT
. ||.|...||..  .  ...||.|||||||||||||| .| ....|.||...|... |...| .||..||  .|| ||| ..|. ..
ktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr

subfamily_PTPRA_pd Subfamily PTPRA 6-322 5.2e-103 339.4 In-house 11-330 (330) alignment
Range on Protein: 6-322
Range on HMM: 11-330/330.0
RQPIPVAELKQHYLRMHANSDLLFEKEYKDIKE-PVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDsESTDYINANWIDGFKQEKKYIATIGP
  |.|| .|..   .  |.   || .|.. .   |.. |   ...  || |||. ||  ||.|||||| ..|  |..||||| .|||.|. .|.||. ||
yfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGv.eesdyinasfidGykekdkfiaaqGP

KAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEEN-EQYGEIIVTLEEKEELADFEIRKFFLRKLSNQM---ETRMVKHFYFTSWPDHDVPEY
|.||  |||||.||.||. .||||.| |. . ||..|||.|    ||.| |..|....| |. .||| ...|....   ..|.|. |.||||||  ||  
keetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfe

ATGLLEFWKRVRNSwEGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLR
. |.|.. |.|..  .  ..|||.|||||||||||||||.||..|..| |...||.  |.|.|.||  |||   || ||. .|||   .||||..|  | 
piGmlkllkkvkkl.nqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvssle

MRLMQLAEKVAGTGMTGLEREF
 .| .| .|..||  .||| ||
khlqklynkitgtdkigleeef

0051299 (Phosphotyrosine protein) phosphatases II 7-287 3e-101 333.9 In-house 3-286 (288) alignment
Range on Protein: 7-287
Range on HMM: 3-286/288.0
QPIPVAELKQHYLRMHANSDLLFEKEYKDIKEPV-NVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGdSESTDYINANWIDGFKQEKKYIATIGPK
 .|.| || ...|...||.  ....|.... .   ..|....    |..|||| .| .||||||.||...| .|..|||||..|||.....|.||| ||.
teisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldg.vegsdYinAsyidgynlkrkfIatqgPl

AETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWP-EENEQYGEIIVTLEEKEELADFEIRKFFLRKLS---NQMETRMVKHFYFTSWPDHDVPEYA
 .|..|||||.||......||||||||.|..||..||| .. ..||.| ||| . |.|.|. .|.. ...|.    . |.|.|.||..|.||||.||...
pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

TGLLEFWKRVRNSWEgPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAV
. ||.|...||.. . ...||. ||||||||||||||..| ..||...|. .||...| |.| ||..||| |.|| |...||||..
ellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

subfamily_PTPRG_pd Subfamily PTPRG 9-300 5e-101 333.6 In-house 1-300 (563) alignment
Range on Protein: 9-300
Range on HMM: 1-300/563.0
IPVAELKQHYLRMHANSDLLFEKEYKDIKEPV---NVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDSESTDYINANWIDGFKQEKKYIATIGPK
.|| |...|   .||..|  |..|...... .   .... | ..  || |||| || |||.||| ||.. |  .. ||||||.|||....|..||| || 
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

AETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEE-NEQYGEIIVTLEEKEELADFEIRKFFLRKLS-----NQMETRMVKHFYFTSWPDHDVPE
..|. |||||.||....|.||.|.|||.|. ||. |||..  |.||.. |||.|.| ||   .|.. ...|      .. . ..|... .|.||||.|||
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPe

YATGLLEFWKRVRNSwEGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNL
...  | | |.   . .  . |||.||||||||||||.||.|....||..||  .|.  . .|||||||.||   || |.| |||||.. ..||.  ...
hslpvLifvkkssaa.nkaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqv

R
.
e

0040438 (Phosphotyrosine protein) phosphatases II 13-325 7.9e-101 332.7 In-house 4-314 (317) alignment
Range on Protein: 13-325
Range on HMM: 4-314/317.0
ELKQHYLRMHANSDLLFEKEYKDIKEPVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGdSESTDYINANWIDGFKQEKKYIATIGPKAETTSDF
.|....|......  ....|..|. .    |...   . ||.|||| .|  ||||||.||...|  ...|||||...||... .|.||| ||. .|. ||
dlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplgg.dldsdYInAsyvdgpnlkrkfIatqgPlpntvedF

WRMMWEHKSSIVVMLTKLVEKGKVKCHKYWP-EENEQYGEIIVTLEEKEELADFEIRKFFLRKLsNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRV
|||.||......||||.|.|.|..||..||| .|  .||...||| . ||||....|.. . .| .  |.|.|.||..|.||||.||.. . ||.| ..|
wrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleav

RNSWEgPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLRMRLMQLAEKVA
|.. | ...||. ||||||||||||||... |.||...|. .||.. | ..|.||. .|| |.|| |...|||| .....| .....| ..|..| ...|
reale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllkllipla

GTGMTGLEREFQLL
...... |.|..||
lddvklkekelkll

0050432 (Phosphotyrosine protein) phosphatases II 8-291 1.6e-99 328.4 In-house 25-303 (308) alignment
Range on Protein: 8-291
Range on HMM: 25-303/308.0
PIPVAELKQHYLRmhANSDLLFEKEYKDIKEPVN-VTTRHCDNLINKPKNRYGNIKAYDHSRVILssvqgdSESTDYINANWIDGF--KQEKKYIATIGP
...| .| ... .  |..  |.|.|.... .  .  .....    ||.|||| .| .||||||.|      .|..|||||...||.  |...|.||| ||
klsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl......degsdYInAsyvdgyssklprkfIatqgP

KAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEE----NEQYGEIIVTLEEKEELADFEIRKFFLRKLSNQmETRMVKHFYFTSWPDHDVPEY
. .|. |||||.||......||||||||.|..||..|||.|     ..|| . ||| . |.|.|. .|.. |..|... |.|.|.||..|.||||.||..
lpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg.esrtvthfhytnWpdhgvPps

ATGLLEFWKRVRNSWegpQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGD
.. ||.|...||.|    ..||| ||||||||||||||..| ..||...|. .||...| ..| ||..||| |.|| |...|||| . .  
peilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl

0046845 (Phosphotyrosine protein) phosphatases II 31-294 2e-97 321.2 In-house 4-281 (284) alignment
Range on Protein: 31-294
Range on HMM: 4-281/284.0
KEYKDIKEPVNV---TTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDSESTDYINANWIDGF-----KQEKKYIATIGPKAETTSDFWRMMWEHKSS
.|.. .   .     .....  . |. |||| .| .||||||.|.|..||.|..|||||...||.     ...||.||| ||. .|. |||||.||....
eefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvr

IVVMLTKLVEKGKVKCHKYWPEEN--EQYGEIIVTLEEKEELADFEIRKFFLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEG-PQ
..||||.|||.|..||..|||.|.   .||...||| ..|.  |. .|.. |..|.   |.|.|.||..||||||.||.... ||||.. ||.. |  |.
vIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpg

SGPITVHCSAGVGRTGTFIVIDAMMEQIKEEN---LLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEI
.||| ||||||||||||||..| ..||...|.    .||...|.|.| ||..||| ..|| |...||||.. .. | .
ggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltll

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 12-294 3.2e-96 317.1 In-house 12-297 (298) alignment
Range on Protein: 12-294
Range on HMM: 12-297/298.0
AELKQHYLRMHANSDLLFEKEYKDIKEPVN----VTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDsESTDYINANWIDGFKQEKKYIATIGPKAE
| |..    .....   ...|.. ...  .     ...   .  || |||| .| |.|.|||.|.....| | .||||| .....|... .||| .|  |
aalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedad.eesdYiNAsflhaykgrnafiatqaPlte

TTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPE-ENEQYGEIIVTLEEKEELADFEIRKFFLRKLSNQmETRMVKHFYFTSWPDHDVPEYATGLLE
|..|||||..|.... .||||.|.|..|.|.|||||. ..|.|||| |.| .||| ||...||... | ... ..|.|... ||||||..|||.|| .|.
tvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvld

FWKRVRNSWEGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEI
. ..|| | .     |..|.|||||||.||||.||...|..|.|. .||. .| ..|..|  .||  .||.||..| |||.. ...||
llrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei

subfamily_PTPRK_pd Subfamily PTPRK 9-323 5.1e-96 316.2 In-house 4-313 (314) alignment
Range on Protein: 9-323
Range on HMM: 4-313/314.0
IPVAELKQHYLRMHANSDLLFEKEYKDIKEPVNVTTRHcDnliNKPKNRYGNIKAYDHSRVILSSVQGDSeSTDYINANWIDGFKQEKKYIATIGPKAET
| ||.| |.   ....    | .||. . |  ... .. .   |. |||.|.| |||.|||.| ...||. |.|||||..||..|. ...|.| ||. ||
irvadllqsiallkraegygfkeeyeslfegwdaakkd.e...nreknrsgdilaydrsrvflitidgdp.ssdyinaalidsykrpaafivtqgPlqet

TSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEENEQYGEIIVTLEEKEELADFEIRKFFLRKL-SNQMETRMVKHFYFTSWPDHDVPEYATGLLEF
. ||||........ .||||.|||.|.||| |||||. |.||.| |.| | | ||.. .| | ..||  .| |.|.|..| |..||||||| .|||||..
vkdfWrlvydencasivmltelvevgrvkClkyWPedtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllkl

WKRVRnSWEGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLRMRLMQLA
 .||  ... .. |.| |||||| |||||||.|| ... |..|...||.  |  .|...  ||.   || ||. ..|||.  |.| | | ...   ..  
vrrvk.ksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalylesi

EKVAGTGMTGLEREFQ
.  . |  . |. |||
rldpqtnssqlkeefq

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 7-306 4.5e-95 313.3 In-house 2-302 (305) alignment
Range on Protein: 7-306
Range on HMM: 2-302/305.0
QPIPVAELKQHYLRMHANSDLLFEKEYKDIKEPVNVTTRHCdNLINKPKNRYGNIKAYDHSRVILSSVQGDSeSTDYINANWIDGFKQEKKYIATIGPKA
..| ...|...   ....||  .|..|| . |  . .  .. .  || |||. .|  .|..|.||.  . .   .|||||...||.|..||||.. ||  
kiialddlaayikearvysdkgleaqykslyeeeesidvgk.keankaknrlkeitlldddriiltekesld.dsdyinasyvdgykrkkkyivaqgPlk

ETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEENEQ---YGEIIVTLEEKEELADFEIRKFFLRKLSNQMETRMVKHFYFTSWPDHDVPEYATG
.| .||||...| | | .|||||||| || ||..||||.  .   .||..|.|..... .|. .||. . . ... |.| | .. .|.|||| ||..|| 
ntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfats

LLEFWKRVRNSWEGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLRMRL
||.. |||.....  .  |..|||||||||||.||..| ..|..|.|. .||. .. ..| .|  |||   || |.| || | .| |||.| ..|||.|.
llslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarv

MQL
 .|
nkl

0036941 (Phosphotyrosine protein) phosphatases II 19-302 1.4e-94 312.1 In-house 5-292 (297) alignment
Range on Protein: 19-302
Range on HMM: 5-292/297.0
LRMHANSDLLFEKEYKDIKEPVNVTT-RHCDNLINKPKNRYGNIKAYDHSRVILssvqgDSESTDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMW
| .....  |..||.... .  .  . ..  .. |..|||| .| .|||.||.|     |.|..|||||...||.....|.||| ||. .|. |||||.|
llekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl.....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvw

EHKSSIVVMLTKLVEKGKVKCHKYWP---EENEQYGEIIVTLEEKEE--LADFEIRKFFLRKLSNQmETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVR
|......||||.|||.|..||..|||   .|  .||...||| . |.  |.|. .|.. . .. |. |.|.|.||..|.||||.|||... ||.|...||
eqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgng.esrtvthfhytgwpdhgvpespaslldfielvr

NSWEGP-QSGPITVHCSAGVGRTGTFIVIDAMMEQIK---EENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLRMR
.  .   ..||. |||||||||.||||..| |..|..   .|. .|....|  .| ||...|| ..|| |...|||| . ...| .....| ..
kvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllklvll

0045450 (Phosphotyrosine protein) phosphatases II 5-286 2.4e-93 308.5 In-house 5-303 (307) alignment
Range on Protein: 5-286
Range on HMM: 5-303/307.0
TRQPIPVAELKQHYLRMHANSDLLFEKEYKDIKEPVN---VTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDSESTDYINANWI--------DGFK
. ..|..  | ...|......  ...||......       ....   . ||.|||| .| .|||.||.|||..|..|..|||||...        ||..
lslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgyd

QEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEENE--QYGEIIVTLEEKEELADFEIRKFFLRKLSNQMETRMVKHFYFTS
. .|.||| ||. ||  |||||.||......||||.|||.|..||..|||.|.|  .||.. ||| ..|.|... .|.. .  |.   |.|.|.||..|.
lkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytg

WPDHDVPEYATGLLEFWKRVRNSWEGP-QSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENL---LDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEA
||||.||..   ||.|...||.  |   ..||. ||||||||||||||... |..|...|.    .|... |...|.||  .|| |.|| |...|||| 
wpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel

0039614 (Phosphotyrosine protein) phosphatases II 7-290 3.6e-93 307.5 In-house 12-292 (297) alignment
Range on Protein: 7-290
Range on HMM: 12-292/297.0
QPIPVAELKQHYLRMHANSDLLFEKEYKDIKEPVNvTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDSESTDYINANWIDGFKQ-EKKYIATIGPK
 |||.  | ...|...|||  |...|...... .   ....    ||.|||| .| .||||||.|... |  ...|||||...||...  .|.||| || 
ipiplsvldlllllekansktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPl

AETTSDFWRMMWEHKSSIVVMLTKLVEKGKvKCHKYWPEENEQYGEIIVTLEEKEELADFEIRKFFLRKlsnQMETRMVKHFYFTSWPDHDVPEYATGLL
 ||. |||||.||......||||||||.|. ||..||||| ..||.. ||| . |.|... .|.. ...     |.|.|.|| .|.||||.||.... ||
petvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeeggtygdftvtllkvehldgytvrtlevtn...ngesrtvthfqytgwpdhgvppslelll

EFWKRVRNSWEGP-QSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFG
|| . ||.  .   ..||. ||||||||||||||... |.||...|  .||.. |...| ||. .|| |||| |...|||| . ..
eflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk

0047943 (Phosphotyrosine protein) phosphatases II 18-286 5.6e-93 306.6 In-house 3-271 (273) alignment
Range on Protein: 18-286
Range on HMM: 3-271/273.0
YLRMHANSDLLFEKEYKDIKEPVNVTT-RHCDNLINKPKNRYGNIKAYDHSRVILssvqgDSESTDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMM
.|......  |...|......  .. | ...    || |||| .| .||||||.|     .....|||||...||.....|.||| ||. .|. |||||.
lllekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl.....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmv

WEHKSSIVVMLTKLVEKGKVKCHKYWPEE----NEQYGEIIVTLEEKEELADFEIRKFFLRKLSNQMeTRMVKHFYFTSWPDHDVPEYATGLLEFWKRVR
||......||||.|||.|..||..|||.|     ..||...||| . |. .|. .|.. |..|...  .|.|.||..|.||||.||.. . ||||.. ||
weqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvr

NSWEGP-QSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEA
.  |   ..||. ||||||||||||||..| ...|...|. .||...| ..| ||  ||| |.|| |...|||| 
kalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley

0043336 (Phosphotyrosine protein) phosphatases II 8-285 5.1e-92 303.5 In-house 1-275 (278) alignment
Range on Protein: 8-285
Range on HMM: 1-275/278.0
PIPVAELKQHYLRMHANSDLLFEKEYKDIKEPVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGdSESTDYINANWIDGFKQEKKYIATIGPKAE
||.| .| ...|....|.  |...|.... .    |....  . ||.|||| .| .||||||.||...|  ...|||||...||... .|.||| ||  |
pisvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllgg.dldsdYinAsyvdgynvprkfiatqgPlpe

TTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEENEQYGEIIVTLEEKEELADFEIRKFFLRKLSNQMEtRMVKHFYFTSWPDHDVPEYATGLLEF
|. |||||.||......||||.|||.|.|||..|||.. ..||.. ||| . |.|.|. .|.. . .| .  . |.| |.....||||.|||  . ||.|
tvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdges.rtvthyhylgwpdhgvpeslsllldf

WKRVRNSWEgPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLE
 |.||.  | ...||. ||||||||||||||... ..||.. |  .|... |...| ||  .|| |||| |...||||
lkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle

subfamily_Ptp69D_pd Subfamily Ptp69D 8-305 1.6e-90 298.4 In-house 3-304 (307) alignment
Range on Protein: 8-305
Range on HMM: 3-304/307.0
PIPVAELKQHYLRMHANSDLLFEKEYKDIK-EPVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDSEsTDYINANWIDGFKQEKKYIATIGPKA
.|.. .|.. .   . ..| ...|||. .. . .. .|.  ..  |. |||| .|||.|. ||.|. ..|. . .|||||..| |.|..||.||  .|  
aiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingked.sdYinasfikgykekkkfiaaqdPve

ETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWP-EENEQYGEIIVTLEEKEELADFEIRKFFLRKLSNQM----ETRMVKHFYFTSWPDHDVPEYA
.|  |||||..| .. ..|||..| || . ||.|||| |.. |||.|.|.| ..|.  |. ||.. . |  ..     ..| |  . .|.|.|  ||| |
atigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPeva

TGLLEFWKRVRNSWEGpQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLRM
.|||.. ..||.  .  . .||.|||||||||.|.|. .| ...|.|.|. .|..  |  .| |||..||.  ||.|.. |||.  ..|||...|..|  
rgllklieqvrelykl.nrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddled

RLMQ
.. .
aier

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 48-288 3.9e-90 296.4 In-house 5-243 (250) alignment
Range on Protein: 48-288
Range on HMM: 5-243/250.0
DNLINKPKNRYGNIKAYDHSRVILSSVQGDSEStDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVkCHKYWP-EEN
 .. || |||| .| |.|.|||.| ...|| || ||||| ...|....| .||| ||  .|. |||||..|.||. .||||.|.|..|. .|.||| |. 
kkpqnkeknryadiialdssrvvLekekgdkes.dyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPveka

EQYGEIIVTLEEKEELADFEIRKFFLRKLSNQmETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGPQSGPITVHCSAGVGRTGTFIVIDAMMEQ
|.||.. |.| .||| ||...||..| | ... . |.|... |..|||  |||.||  ||. |.|. | .  ...|. |.|||||||.|.||.|||..|.
ekyGdvtvsllskeefadytkrklklskakka.derivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavler

IKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVT
.|.|. .||. .. ..|..|  .|.  .||.|.. ..|.|..
lkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 14-287 2.3e-87 287.6 In-house 2-276 (281) alignment
Range on Protein: 14-287
Range on HMM: 2-276/281.0
LKQHYLRMHANSDLLFEKEYKDIKE-PVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQgDSESTDYINANWIDGFKQEKKYIATIGPKAETTSDF
|..|  ....|..  | .||.....  |. |..   .  |. |||| || |||..|| ..  . ....|||||||...|.|.||.|||| ||  ..  .|
lrkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpne.enkntDYinanfvpgykgekeyiatqgPvPaslvaf

WRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEEN--EQYGEIIVTLEEKEELADFEIRKFFLrkLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKR
|.|.||.| |..||.|. .|.||.|||.|||..|   .||...|. ...|| | .  ||| |    .. ||| |... .|.|||| ||. .. |||| | 
WqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl..eresgetreveqlaytaWPdhGvPattkellefrke

VRNSWEGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEE-NLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAV
|..  |  .  |. .|||||||||||.| .| .......| . |||   |  .| .||.|||   ||.|.. |.|.|.
vlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 14-286 7.1e-87 286.1 In-house 9-278 (288) alignment
Range on Protein: 14-286
Range on HMM: 9-278/288.0
LkQHYLRMHANSDLLFEKEYKDIkEPVNVTT--RHCDNLINKPKNRYGNIKAYDHSRVILSSVQgDSESTDYINANWIDGFKQEKKYIATIGPKAETTSD
. ..  ...|..   |..||. .  ... |       .  |..|||| || .||. || |  .. . ...|||||..||| |..|||||| || |.|  |
v.akvakksarnrtgfseeynsL.aalektksvtagrlavnakknRyrnilpyDekrvklkkle.eeagaDYinasyidgekkkkkyiatqgPladtvnd

FWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEENE--QYGEIIVTLEEKEELADFEIRKFFLRklsNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWK
||....|.|.| .||||.|||.|| ||..|||....  .||.. ||| |..|| ||  ||. |     ... . .... ...||||.||| .. |||. .
fWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellr

RVRNSWEGPqSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEA
 | .. .   .|||.||||||||||||||..||......||. .|| . |...| ||...||  .|| ||. .||. 
qvkvanqad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsl

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 6-322 1.3e-85 282.1 In-house 3-314 (315) alignment
Range on Protein: 6-322
Range on HMM: 3-314/315.0
RQPIPVAELKQHYLRMHANSDLLFEKEYKDIKEPVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDSeSTDYINANWIDGFKQEKKYIATIGPK
.||||. .|  .  . .|..   |...|. |        .   .  || |||| || |||.||| |  .. |.  .||.|||.|||......|||. ||.
hqpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendp.hsdyvnanfidGynkkrryiaaqgpn

AETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEENEQYGEIIVTLEEKEELADFEIRKFflrKLSNQMETRMVKHFYFTSWPDHDVPEYATGLL
...  ||||...|.. . .||||.|||. | |. ||||...  ||.| ||. ..|   .. .| .       . . | |  . .||||| .||.|.. |.
vasvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviyGkitvtrkseevnteytvrtl...svvfgdnirevvqlhytswpdmgvpkytiplm

EFWKRVRNsWEGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEvQNLRMRLMQ
.. ..|.  ..  . |.| |||||||||||||| .||...|.. ||..||| .. ..|..|  |||   || ||. ||||..  ||| |  |.| .   .
nlirtvkq.hhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsia.qdlylqryd

-LAEKVAGTGMTGLEREF
 |      || | |. .|
sllapspdtgstllqeqf

DSPc_SM00195 29-287 1.4e-84 278.9 In-house 2-262 (263) alignment
Range on Protein: 29-287
Range on HMM: 2-262/263.0
FEKEYKDIKEPV-NVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDsESTDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVML
...|.....|   . .|.. .   || |||| ||. |||.||.|.. ... |..||||||.|.| ...|||||| ||. .| .|||||.||.|..|.|||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk.egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

TKLVEKGKVKCHKYWPEE---NEQYGEIIVTLEEKEELA-DFEIRKFFLRKLSNqMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGPqSGPI
|. .|.|| ||..|||||   .|..|.| |.| |.|.   ....|.. |.|  .  ||| |... ...||||.||. .. .||. . |..| .   ||||
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpi

TVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAV
 |||||||||||||..|| ......||. .|. . |...| ||  |||   ||.||. |.||..
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 29-287 1.4e-84 278.9 In-house 2-262 (263) alignment
Range on Protein: 29-287
Range on HMM: 2-262/263.0
FEKEYKDIKEPV-NVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDsESTDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVML
...|.....|   . .|.. .   || |||| ||. |||.||.|.. ... |..||||||.|.| ...|||||| ||. .| .|||||.||.|..|.|||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk.egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

TKLVEKGKVKCHKYWPEE---NEQYGEIIVTLEEKEELA-DFEIRKFFLRKLSNqMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGPqSGPI
|. .|.|| ||..|||||   .|..|.| |.| |.|.   ....|.. |.|  .  ||| |... ...||||.||. .. .||. . |..| .   ||||
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpi

TVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAV
 |||||||||||||..|| ......||. .|. . |...| ||  |||   ||.||. |.||..
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

Y_phosphatase Protein-tyrosine phosphatase 52-285 3.6e-84 277.2 Pfam-A 1-235 (235) alignment
Range on Protein: 52-285
Range on HMM: 1-235/235.0
NKPKNRYGNIKAYDHSRVILssvQGDSESTDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWP---EENEQ
|| |||| .| .||..|| |   .|.....||||||...|.|..||.||| ||  .| .|||||.|..|....||||.|.|||..||..|||   || ..
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGEIIVTLE--EKEELADFEIRKFFLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWeGPQSGPITVHCSAGVGRTGTFIVIDAMMEQ
||.| |.|.  |||. ... .||. |.|  .. |.|.||.. .|.||||.||| ...||.. ..|..|   ..|||..|||||||||||||...|...||
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleq

IKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLE
...|. .||...|...|.||. |||. .|| |.. |.||
leaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

Y_phosphatase Protein-tyrosine phosphatase 52-285 3.6e-84 277.2 In-house 1-235 (235) alignment
Range on Protein: 52-285
Range on HMM: 1-235/235.0
NKPKNRYGNIKAYDHSRVILssvQGDSESTDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWP---EENEQ
|| |||| .| .||..|| |   .|.....||||||...|.|..||.||| ||  .| .|||||.|..|....||||.|.|||..||..|||   || ..
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGEIIVTLE--EKEELADFEIRKFFLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWeGPQSGPITVHCSAGVGRTGTFIVIDAMMEQ
||.| |.|.  |||. ... .||. |.|  .. |.|.||.. .|.||||.||| ...||.. ..|..|   ..|||..|||||||||||||...|...||
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleq

IKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLE
...|. .||...|...|.||. |||. .|| |.. |.||
leaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

0045098 (Phosphotyrosine protein) phosphatases II 42-287 8.5e-83 273.2 In-house 23-272 (278) alignment
Range on Protein: 42-287
Range on HMM: 23-272/278.0
VTTRHCDNLINKPKNRYGNIKAYDHSRVIlssvqgdsestDYINANWIDGFkqEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKY
 .  .   | |..|||| .| .||||||.           |||||..|||.   ||.||| ||. .|..|||||.||......||||.|||.|..||..|
seitpalylgnldknRykdilpydhsrVk...........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqy

WPEEN-EQYGEIIVTLEEKEELADFEIRKFFLRKL---SNQMETRMVKHFYFTSWPDHDVPEYA--TGLLEFWKRVRNSWE------------GPQSGPI
|||.. ..||.. |||.. |.| |. .|.. .. |    .  |.| |.|.....||||.||..   . .||.....|.  .             ...||.
wpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpv

TVHCSAGVGRTGTFIVIDAMMEQIkeENLLDVYSYVSRIRAQRNF-MVQRPSQYSFIHYALLEAV
 ||||||||||||..... |.|..  |. .|....|. .| ||.. .|| ..|| |....||| .
lVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell

subfamily_PTPN9_pd Subfamily PTPN9 29-285 1.6e-82 271.9 In-house 18-288 (297) alignment
Range on Protein: 29-285
Range on HMM: 18-288/297.0
FEKEYKDIK-EPVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDsESTDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVML
  |||..|. |||. |  .     |  |||| ..  ||..|| |..|..| | .||||||..||.||.| .||| ||  .|.||||||.||..  ..|| 
lskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvded.easdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmt

TKLVEKGKVKCHKYWP---EENEQYGEIIVTLEEKEELADFEIRKFFLRKLSNqMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRN-----------
|..||.|..|| .|||   |. ...|.. |.  | ||  |...|.. ...  .  |.| | || |.||||. ||. |. ||.. . ||.           
trvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkt.eesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgd

SWEGPQSG-PITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLE
.|.|. || || ||||||.||||||| .|  .....|.. .||   |...|.|| |..| | || | . |.||
ewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle

0040439 (Phosphotyrosine protein) phosphatases II 46-286 4.2e-82 270.7 In-house 5-245 (249) alignment
Range on Protein: 46-286
Range on HMM: 5-245/249.0
HCDNLINKPKNRYGNIKAYDHSRVILSSVQGdSESTDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWP-E
..  . ||.|||| .| .||||||.||...|  . .|||||..|||... ...||| ||  ||..|||||.||......||||.|||.|..||..||| .
vallpenkdknrypdilpydhsrvklsilpg.lflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplg

ENEQYGEIIVTLEEKEELADFEIRKFFLRKLsNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGP-QSGPITVHCSAGVGRTGTFIVIDAM
.  .||.. ||| . |...|. .|.. | .|    |.|.|.|...|.||||.||..   ||.|...||.  |   ..||. ||||||||||||||... |
gsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylm

MEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEA
.||...|. .|....|. .| ||. .|| |.|| |...|||| 
leqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 15-309 8.5e-81 266.7 In-house 21-313 (319) alignment
Range on Protein: 15-309
Range on HMM: 21-313/319.0
KQHYLRMHANSDL-LFEKEYKDI-KEPVNVTTRHCDNL-INKPKNRYGNIKAYDHSRVILSSVQGDsESTDYINANWIDGFKQEKKYIATIGPKAETTSD
.|   . ... ||  .| |.. . | .|| ...   ||  || |||..|| |.|...| |  ..|  | .||||| ...|.....||||. ||. .|  |
qqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGe.efsdyinasfvtGyqrkdkyiaaqGPldntlad

FWRMMWEHKSSIVVMLTklvekgKVKCHKYWPEE-NEQYGEIIVTLEEKEELADFEIRKFFLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKR
||||.||...| .|.||      | || .||| . ......  | ..  || |.. .|.. | . ... . | .. |.|  |||. ||.|.. |. . |.
fWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkk

VRNSWEGP-QSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLRMRLMQLAEK
||   .   .  .| |||||||||||..||.|......|||. .||| .|  .| ||| .||   || ||. ||||   || ... . ..   | .|..|
vrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleelsnk





0042113 (Phosphotyrosine protein) phosphatases II 49-285 2.3e-80 264.8 In-house 6-241 (245) alignment
Range on Protein: 49-285
Range on HMM: 6-241/245.0
NLINKPKNRYGNIKAYDHSRVILSSVQGdSESTDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWP-EENE
 . ||.|||| .| .|||.||.||...| .. .|||||...||... .|.||| || .||. |||||.||......||||...|.|.|||..||| .|  
lpenkdknrysdilpydhtrvklspdgg.dldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesl

QYGEIIVTLEEKEELADFEIRKFFLRKLsNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGPQSGPITVHCSAGVGRTGTFIVIDAMMEQI
.||...||| . | |.|. .|.. . .|    |.|.| |.....||||.||..   ||.| ..||.  . ...||. ||||||||||||||... |.||.
tygdftvtllseehlddytvrtlevtnl.gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleql

KEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLE
..|  ..... | ..| ||  .|| |||| |...||||
ekelgvsleeavkelrsqRpgavqtpsqyrflyealle

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 7-324 3.9e-79 260.7 In-house 1-314 (315) alignment
Range on Protein: 7-324
Range on HMM: 1-314/315.0
QPIPVAELKQHYLRmhANSDLLFEKEYKDIKEPVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQgDSESTDYINANWIDGFKQEKKYIATIGPKA
||||||..     .       || .|..|. .|    .| . . || .||||.||  .|..||.|  .. ||   |||||  | .....| |||. ||. 
qpipvaqfpafvnk..nrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvklevid.dsPdsdyinasyiksvdddkayiasqgPlk

ETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPE---ENEQYGEIIVTLEEKEELADFEIRKFFLRKlsnQMETRMVKHFYFTSWPDHDVPEYATG
 . .|||||....| . .||.||. |  |.|| .|||.   .  ..|.| |.| . |  .|  .||. .||     |.| |  | || |||. |.. .. 
asvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrk...seesrtvtqfqftewPdkGvdkqtss

LLEFWKRVRNSwEGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLRMRL
||.. | |. . .|..  .. ||||||||||| .| || ...|||... .||. .|  .||.| ..||   .|.||. |.|| . . .| | | ..  .|
llklikevkad.ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhl

MQLAEKVAGTGMTGLEREFQL
 .|   | |.| . . .||. 
qdlhtsvdgsgrskmtkefet

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 33-309 1.2e-78 259.5 In-house 4-277 (284) alignment
Range on Protein: 33-309
Range on HMM: 4-277/284.0
YKD-IKEPVNVTTRHCDNL-INKPKNRYGNIKAYDHSRVILSSVQGDsESTDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTkl
..   | .|| |..   ||  || |||.|.| |.|...| |  ..|  | .||||| .| |.....||||| ||. .|  |||||.||...| .|.||  
frracklgvngtdqtfanldqnkdknrighilafdknvvklerliGe.efsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt..

vekgKVKCHKYWPEE-NEQYGEIIVTLEEKEELADFEIRKFFLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGP-QSGPITVHCS
    | || .||| . ......  | ..  || ... .|.. | . ... . | .. |.|  |||. ||.|.. |. . |.||   .   .  .| ||||
....kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcs

AGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLRMRLMQLAEK
|||||||..||.|......|||. .||| .|  .| ||| .||   || ||. ||||   || ... . ..   | .|..|
agvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleelsnk

0037934 (Phosphotyrosine protein) phosphatases II 49-285 4.3e-78 257.5 In-house 7-240 (243) alignment
Range on Protein: 49-285
Range on HMM: 7-240/243.0
NLINKPKNRYGNIKAYDHSRVILssvqgdsESTDYINANWIDGFKqekKYIATIGPKAETTSD----FWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPe
 . |..|||| .| .||||||.|       |..||||||.|....   ..||| ||  ||. |    ||||.||......||||.|||.|..||..||| 
lpenlsknrysdilpydhsrvkl.......egsdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.

ENEQYGEIIVTLEEKEELADFEIRKFFLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEG-------PQSGPITVHCSAGVGRTGTF
....||...||| . |.|.|. .|.. |. |. . .||.| |.....||||.||.  . ||.|.. ||.  |        ...||. ||||||||||||.
gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtl

IVIDAMMEQIkeeNlLDVYSYVSRIRAQRNF-MVQRPSQYSFIHYALLE
|... |....   . .|....| ..|.||.. .|| |||| |...||||
iaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyealle

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 52-285 1.3e-77 255.2 In-house 3-237 (237) alignment
Range on Protein: 52-285
Range on HMM: 3-237/237.0
NKPKNRYGNIKAYDHSRVILSSVQGDsesTDYINANWIDGFKQ-EKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEEN--EQ
|| |||||||.|||||||.|    ..   .|||||....||    |||||. ||   .  |||.|.|. | |..|||| |.|. ..|||||||. .  . 
nkiknrygnivaydhsrvvlkgagsg...sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGEIIVTLEEKEELADFEIRKFFLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEG-PQSGPITVHCSAGVGRTGTFIVIDAMMEQI
|| . |.|  |||..|. .| . | |  .. | |... . ||||||. ||.... || | |.. |  .  ..|||  .|||||||||| |.|||||. | 
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

KEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLE
||....|.| ||  |  .| ...|   || ||| ..||
kekkvvdiynyvysieedrpyiiqtkdqyvfihqtile

subfamily_PTPN6_pd Subfamily PTPN6 29-285 1.4e-77 255.7 In-house 28-295 (306) alignment
Range on Protein: 29-285
Range on HMM: 28-295/306.0
FEKEYKDIK--EP-VNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSsvQGDSESTDYINANWIDG--FKQEKKYIATIGPKAETTSDFWRMMWEHKSSI
||.|.....  |    .. .. .   || |||| ||  .||.||||.  . .   .|||||| |..   ...|.|||| |   .| ||||||.|. .| .
feeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk..epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrv

VVMLTKLVEKGKVKCHKYWPEEN--EQYGEIIVTLEEKEELADFEIRKFFLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGPQ--
.||.|| ||.|| || .|||.|.  |.||.| ||  ....|||...|.. . | ... |.| | .. |.|||||.||.    .|.|.. |..  |  .  
ivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleea

-SGPITVHCSAGVGRTGTFIVIDAMMEQIKEENL---LDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLE
 .||| ||||||.||||||||||.....|... |   .|... |  .|.||. .||  .|| |...|. .
eagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikk

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 290-577 3.2e-77 254.7 In-house 1-295 (298) alignment
Range on Protein: 290-577
Range on HMM: 1-295/298.0
GDTEIEVQNLRMRLMQLAEKVAGTGMTGLEREFQLLNGAVPdELSDF--YTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKV
|.||||...|.. | .||..   ...||.. ||| ||     |. ..    | .|.| |||||..|.. . .|||| .. ..|...|||||.|..|... 
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvss.eieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn

AFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEPLEVFFSAIYTY--LCWWGGGRWTLKKT---NGVIVSEINF-NPKTGEVRQISHFMYLEWTEHA
||||||||| .|.|||||||..|.. .||||  |.|  .. ..  .       .|  . .|...     .|| ...  . |. . |.. .. . .|....
afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkg

VPTKLLTIIDLIGDLQKARRKHLDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYLDSFEE
||..  ...||. . .. ...  ..||.|.||.||||.|.|. . . ||||| | |.||| . ..||..|||.|   .||  .|||.| .||||..
vpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnd

0051299 (Phosphotyrosine protein) phosphatases II 291-572 1.7e-76 252.7 In-house 2-286 (288) alignment
Range on Protein: 291-572
Range on HMM: 2-286/288.0
DTEIEVQNLRMRLMQLAekvaGTGMTGLEREFQLLNGAVPDelSDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFI
||||.|..|. ....|      .|.|||..||. |    ||   ....|  |.| .||||..|||....||.|  ... |...||||||..||. | .||
dteisveellklvlkll....angltglleefeellsllpd..ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfI

ATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEplevfFSAIYTYLCWWGGGRWTLKK----------TNGVIVSEINFNP-----KTGEVRQISHFMYL
|||.||.||.||||||||...| .||||..| |     .. .  . .|  || .|...           ....| ..   .     ..||.|.. || |.
atqgPlpntvedFWrmvweqnvrvIvmltklve.....lgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhyt

EWTEHAVPTKLLTIIDLIGDLQKARRkHLDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYL
 | .| ||. .  ..|.. ...||.. . . |||||||.||||||.|..|.  ||... ||..||. . ..||.||||||  ..|||..|||.| ||
nwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 8-332 2.5e-76 251.8 In-house 1-321 (515) alignment
Range on Protein: 8-332
Range on HMM: 1-321/515.0
PIPVAELKQHYLRmhANSDLLFEKEYKDIKEPVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQgDSESTDYINANWIDGFKQEKKYIATIGPKAE
|.|.|..   . .  ..   || .|..|.  |       ... || .||||.||  || .||.|  .. |.   ||.||  | .|. .| |||. ||.  
plplaqfPafvnk..nrhttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevin.dnPhsdyfnasyipsfdndkayiasqgPnka

TTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPE---ENEQYGEIIVTLEEKEELADFEIRKFFLRKLSNqmeTRMVKHFYFTSWPDHDVPEYATGL
...||||...... . ..|.||| |  |.|| ||||.   .  ..|.| | |   |  ..  .||. . | ..   .| |  | || |||. ||. .. |
svddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd...srtvtqfhfteWPdkGvpkhtssl

LEFWKRVRNSWeGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLRMRLM
| . | |. .  |  . |. .|||||||||| .| || .. ..|. . .||. .|  ||..| ..||   ||.||. |.|| . . .| | |  .   | 
lklikevkadh.gqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlq

QLAEKVAGTGMTGLEREFQLLNGAVPDE
.|     | | . . .||| |.  .|| 
dlhssgdgrgrskmtkefqtlkslcpdp

0050432 (Phosphotyrosine protein) phosphatases II 285-575 1.8e-75 249.5 In-house 10-302 (308) alignment
Range on Protein: 285-575
Range on HMM: 10-302/308.0
EAVTFGDTEIEVQNLRMRLMQLAEK-VAGTGMTGLEREFQLLNGAVPdeLSDFYTATQPKNSKKNRYPNILPCERCRVVLpaipdKEDTTYINASYLEGY
|...|.||.| | .|......|...    .....||.||. |.   |  | ....| .|.| .||||..|||....||.|     .|...||||||  ||
elllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkp..lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgy

--QEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEplevfFSAIYTYLCWWGG--------GRW-----TLKKTNGVIVSEINFNP-KTGEVR
    . .|||||.||.||.||||||||...| .||||. | |      . .  .  |           |..       .. ....| ..   . ..||.|
ssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklve.....ngrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesr

QISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKhldRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEA
.. || |. | .| ||...  ..|..  ..| ...    |.|||||.||||||.|..|   ||... || .||| . ..||.||||||  ..||...|.|
tvthfhytnWpdhgvPpspeilldflelvrkslpg...gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyra

ILAYLDSF
.| || ..
lleylklk

subfamily_PTPN12_pd Subfamily PTPN12 37-287 4.2e-75 247.3 In-house 25-277 (290) alignment
Range on Protein: 37-287
Range on HMM: 25-277/290.0
KEPVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDSeSTDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKV
|.   ..| . ..  |. |||| .|  ||.||| ||  ...    ||||||.| | .....|||. || ..| .|||||.||.. .||||. ..|| || 
kaekvysteagekeenvkknrykDilPydksrvelskieeee.gsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkk

KCHKYWPEE---NEQYGEIIVTLEEKEELA-DFEIRKFflrKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEgPQSGPITVHCSAGVG
||..|||||   . ..||. |||||.. .  || || .   |. .| |.|.|. | .|.||||.||. |. |||. . ||.  |  .. |. ||||||||
kCerYWpeegeeelefgefevtleeekavdddflirtL...kveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvG

RTGTFIVIDAMMEQIKEENL---LDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAV
|||| |.|| . |..|.|..   |||.. | ..| ||. .||   ||.... |..| |
rtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv

0046845 (Phosphotyrosine protein) phosphatases II 317-574 1.1e-74 246.7 In-house 1-276 (284) alignment
Range on Protein: 317-574
Range on HMM: 1-276/284.0
GLEREFQLLNGAVPDELSDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDK-EDTTYINASYLEGY-----QEKVAFIATQAPLDNTIEDFWRMVWHE
|||.||. |.  ... | ....|  |.| .||||..||| ...||.|  .... ||..||||||..||       | .|||||.||.||.||||||||..
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

EVFCIVMLCGLNEplevfFSAIYTYLCWWGGG-R----------WTLKKTNGVIVSEINFNPK--TGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQ
.| .||||..| |     .. .  .  |   |            .  .. ....| ..   ..  |||.|.. || |..| .| ||. .  ..... ...
nvrvIVmltelve.....ngrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvr

KARRK-HLDRPVVVHCSDGVGRTGAFCTLFATLERVKLEG---VLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYLDS
..... . . |.|||||.||||||.|..|   ||... ||   ..||. . ..||.||||||  |.|||..|||.| || .
ellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 29-284 2.1e-74 245.0 In-house 7-265 (274) alignment
Range on Protein: 29-284
Range on HMM: 7-265/274.0
FEKEYKDIkePVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDSESTDYINANWIDGFKQ-EKKYIATIGPKAETTSDFWRMMWEHKSSIVVML
.|||. ..  |.|..... |   .. |||| .|   ..|||.|.| ....| ..|||||.| |... .| |.|| || ..| .|||||.........|||
lekeflel..PlnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivml

TKLVEKGKVKCHKYWPEENEQ-----YGEIIVTLEEKEELADFEIRKFFLRKLSNqmeTRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGP--QS
||| |. . ||..|.|....      ||.. .. |.. |  |...||. |..|..   .| |||...|.||||..|. |. ||.. . |..| |    . 
tklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeenakl

GPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALL
.|. ||||||.|||| || |.  . |..||. .|| . |. .| .|  |||  .|| .|| || 
apvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 5-297 2.2e-73 242.0 In-house 6-294 (297) alignment
Range on Protein: 5-297
Range on HMM: 6-294/297.0
TRQPIPVAELKQhYLRMHANSDlLFEKEYKDIKEPVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDsESTDYINANWIDGFKQekKYIATIGP
 |.|||....   ...   ..| .|..|.... |    ..   .. .| .|.|| ||  || |||.| .|. |  . ||.|| .. |.|.  ..|.|  |
errpiplsdfat.lvqknrhtd.vfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivndd.pdsDyvnasfvkgnkh..rlittqmP

KAETTSDFWRMMWEHKSSIVVMLTKLVEKGKvKCHKYWPEEN-EQYGEIIVTLEEKEELADFEIRKFFLRKlSNQMETRMVKHFYFTSWPDHDVPE--YA
. .|  |||.|..... |..|||... |. | || .||...   ..|.. |.|.  .|   |  |.. ..| ..   .|.|| . |..|||..|..   |
mkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtk.gkakarrvvkqyqfveWPdkaverkdsa

TGLLEFWKRVRNSWEGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQ
. ||.. . ||..... ..||. |||.||||||| .. || .. ..|.|. .|.. .|...| .| ..||   ||.|.. |.|||.   ||.|...
ssllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqas

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 50-286 1.8e-72 238.4 In-house 5-239 (239) alignment
Range on Protein: 50-286
Range on HMM: 5-239/239.0
LINKPKNRYGNIKAYDHSRVILSSVQGDSEStDYINANWIDGFKQ-EKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEENEQ
 .|| |||| || .||||||.|  .  |  | |||||...  .    | |||| |  . .. |||||||. .  ..|||| |.|  | |||.|||.   .
rvnkaknryanivtydhsrvvleklsndphs.dyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk

YGEIIVTLEEKEELADFEIRKFFLRKLsNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSwEGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIK
| .. ||| . | .||. || | . ..  | | | | ...|| |||. ||.||| .| . ... .    | . |  .||||||||||.|.|||||. | |
ycnlrvtlrktevfadyiirtfvmsqv.gqteeryvyqyhftvwpdkgvpqyatavlglrrkitkd.slpgarpwvihcsagvgrtgaflvidamlrqak

EENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEA
... .|.. ||  || .| .|||   || ||| |.|||
kqktvdifnyvkairedrphmvqtseqyvfihlavlea

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 50-285 6.9e-72 236.4 In-house 6-239 (239) alignment
Range on Protein: 50-285
Range on HMM: 6-239/239.0
LINKPKNRYGNIKAYDHSRVILSSVQGDSEStDYINANWIDGFKQ-EKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEENEQ
 .|| |||| || .||||||.|  .  |  | |||||...  .    | |||| |  . .. |||||||. .  ..|||| |.|  | |||.|||.   .
rvnkaknryanivtydhsrvvleklsndphs.dyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk

YGEIIVTLEEKEELADFEIRKFFLRKLsNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSwEGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIK
| .. ||| . | .||. || | . ..  | | | | ...|| |||. ||.||| .| . ... .    | . |  .||||||||||.|.|||||. | |
ycnlrvtlrktevfadyiirtfvmsqv.gqteeryvyqyhftvwpdkgvpqyatavlglrrkitkd.slpgarpwvihcsagvgrtgaflvidamlrqak

EENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLE
... .|.. ||  || .| .|||   || ||| |.||
kqktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_PTPN3_pd Subfamily PTPN3 41-286 4.2e-71 234.1 In-house 30-274 (280) alignment
Range on Protein: 41-286
Range on HMM: 30-274/280.0
NVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSvqgdSEStDYINANWI----DGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKV
.... ..    | .|||| .| .||. ||.|..    ||. ||||||..    .. .. ..|||| || |.|..|||.|.||.|||..|||| |||.|.|
glaisaarkpenlsknryrdilpydatrvklke....set.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrv

KCHKYWPEENE--QYGEIIVTLEEKEELADFEIRKFFLRKlSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGpQSGPITVHCSAGVGRT
|||.||||...  .|||. |..|...|   . .|.. |.. ... | |.. .. ...||||.||. .. .||| .|||.  .| .. |. ||||||.|||
kChqyWPetedeleygefsvkcekedetksyvlrelvlkd.ketkeerkilqlqylaWpdhgvPddsadflefvervrklrsg.keePvvvhCsaGigrt

GTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEA
| .|...  .  | ... . .   |...| ||  .|| .||| |.  |.|..
GvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv

0040438 (Phosphotyrosine protein) phosphatases II 308-572 4.9e-71 234.9 In-house 10-276 (317) alignment
Range on Protein: 308-572
Range on HMM: 10-276/317.0
EKVAGTGMTGLEREFQLLNGAVPDelsDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMV
...   ..|.|..||. |    .|   .. .|  |.| .|||||.|||....||.|  ..  .|..|||||| .|...| .|||||.||.||.|||||||
ldllksdftalleefedllslkld...tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmv

WHEEVFCIVMLCGLNEplevfFSAIYTYLCWWGGGRWT----------LKKTNGVIVSEINFNP-KTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDL
|.. | .||||. | |     .. .  .  |  |. .|           .. .|... .. . . ...|.|.. || |. |..| ||  . ...|..  .
weqgvtvivmLtelee.....lgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleav

QKARRkHLDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYL
..|.. . . ||.||||.||||||.|....  ||... || .||. . ..|| ||||.|  ..||| .|.|.| ||
reale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl

0047943 (Phosphotyrosine protein) phosphatases II 313-572 1.5e-70 233.1 In-house 9-272 (273) alignment
Range on Protein: 313-572
Range on HMM: 9-272/273.0
TGMTGLEREFQLLNGAVPdeLSDFYTATQPKNSKKNRYPNILPCERCRVVLpaipDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEV
.|.|.|..||.||    |  | ....|  |.| .||||..|||....||.|    . ... ||||||..||. | .|||||.||.||.||||||||.. |
lgltllleefelllslkp..lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv

FCIVMLCGLNEplevfFSA--IYTYLCWWGGG-----------RWTLKKTNGVIVSEINFNP-KTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQK
 .||||. | |      .    . |   .||.            .  .. ....| ..   . .|||.|.. || |..| .| ||. |  ....| ...|
rviVmLtelve.....lgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrk

ARRKH-LDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYL
|...   . |||||||.||||||.|..|.  |.... || .||. . ..||.||||||  ..|||..|||.| ||
alealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 11-323 1.8e-70 232.7 In-house 7-324 (325) alignment
Range on Protein: 11-323
Range on HMM: 7-324/325.0
VAELKQHYLRMHANSDLLFEKEYKDIKEPVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSvQGDSESTDYINANWIDGFKQEKKYIATIGPKAETTS
| .| .|  . .|. .  | .|.. .     .. .      || |||. |. |.|.|||.| . ..|. |.|||||...  .|. . ..|.  |...|. 
vvnlvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvlet.kkddpssdyinasylrddkkkdvflaaqaPltatin

DFWRMMWEHKSSIVVMLTKLvEKGKVKCHKYWPEE---NEQYGEIIVTLEEKEELADFEIRKFFLRKLSnQMETRMVKHFYFTSWPDHDVPEYATGLLEF
|.||.. . ..|.||.| .| ..|| .| .|||.|     ..| . | |   ||..|.  |.. ... . . ||| || | . ||.|  |... . |. .
dlWrlvldWrcsvvvvlnel.dlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvk.kGetrsvkqfqlqswddmGvqkrpatlisi

WKRVRNSWEG-----PQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLRMR
 . | .  |        |.|| |||||||||||.|| . ...... ||  .|.. .| ..|..|  ||.   ||..|. || ||.  |.|.. | ..  .
lqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeak

LMQLAEKVAGTGMTGLEREFQ
|  | |.   |    .|.||.
lsslqernpltqklniekefe

0036941 (Phosphotyrosine protein) phosphatases II 313-572 2e-70 232.7 In-house 10-277 (297) alignment
Range on Protein: 313-572
Range on HMM: 10-277/297.0
TGMTGLEREFQLLNGAVPdeLSDFYTATQPKNSKKNRYPNILPCERCRVVLpaipDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEV
.....|..||. |    .  | ....|  |.| .||||..|||....||.|    |.|.. ||||||..||. | .|||||.||.||.||||||||.. |
lflalllkefeellplll..lgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnv

FCIVMLCGLNEpleVFFSAIYTYLCWWGGGRWTLkktNGVIVSEINFNP----------------KTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDL
 .||||. | |     .   . |   . |. .|    ....|  ....                 ..||.|.. || |. | .| ||.   ...|.|  .
tvIvmltelve...lgrekcaqywpleegeslty...gdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielv

QKARRKH-LDRPVVVHCSDGVGRTGAFCTLFATLERVK---LEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYL
.|....   . ||.||||.||||.|.|....  |....    || .|.. . ..||.||||.|  |.||| .|||.| .|
rkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 13-301 6.6e-70 230.7 In-house 6-293 (439) alignment
Range on Protein: 13-301
Range on HMM: 6-293/439.0
ELKQHYLRMHANSDLLFEKEYKDIKE---PVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDSEStDYINANWIDGFKQEKKYIATIGPKAETT
|...|  ... | . .|..... |.    . .. .    .  ...|||| .. |.||.||.|  . |   |  |||||.|.|. ..| |||| ||| |||
efqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphs.hyinanyikGyyddklyiatqgpkkett

SDFWRMMWEHKSSIVVMLTKLVEKGKvkchkYWPEENEQY-GEIIVTLEEKEELADFEIRKFFL-RKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEF
 ||||...|.|.. .||||.|||  |     ||| ..| . |.|.|  . . || .. || | .  .  .    | | .|....|||..||  |. .|.|
ddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldf

WKRVRNSWEGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLRM
 . .  . .  . ||. |||||||||||| | .|  .||.| || .|.   |. .| ||. |||   || ||. |.|| . .||. . ..... 
lrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefkk

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 9-288 1.4e-69 229.1 In-house 2-284 (290) alignment
Range on Protein: 9-288
Range on HMM: 2-284/290.0
IPVAELKQHYLRMHANSDLLFEKEYKDIKEPVNVTTR-HCDNLINKPKNRYGNIKAYDHSRVILSSVQGDSE-STDYINANWIDGFKQEKKYIATIGPKA
||| .. ..    ||. .  |....| ..   .  |  .     ||..||. ||  ||  |..|  ..|. . . .|||| .|.|.|..|.|||| ||  
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

ETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEE-NEQYGEIIVTLEEKEELADFEIRKFFLRKLSNQMETRMVKHFYFTSWPDHD-VPEYATGL
.|  |||...|..|..|.||||. .|.|||||..|||.. ...|||. ..| . |.| .. .||. ... ... ....|... .|.|.... |....| |
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtil

LEFWKRVRNSWEGPqSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVT
| . ..... .     ..| ||||..|||...|....  ... | |   ||.. . . | |.  .||   || .|.. .|....
lvieemyktqrkrg.ntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld

0045450 (Phosphotyrosine protein) phosphatases II 308-572 1.8e-69 230.1 In-house 19-304 (307) alignment
Range on Protein: 308-572
Range on HMM: 19-304/307.0
EKVAGTGMTGLEREFQLLNGAVPDELSDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDK-EDTTYINASYL--------EGYQEKVAFIATQAPLDN
 .   ...|||..||. |.   .. | ....|  |.| .||||..|||....||.|  .... ||. ||||||         .||  | .|||||.||..
llllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpe

TIEDFWRMVWHEEVFCIVMLCGLNEPlevFFSAIYTYLCWWgGGRW----------TLKKTNGVIVSEINFNP--KTGEVRQISHFMYLEWTEHAVPTKL
|.||||||.|.. | .||||..| |     .  .. |     |. .            .. .|..|  ..  .  .|||.|.. || |..| .| ||. .
tvedFwrmlweqgvtvivmltelvel...grekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsf

LTIIDLIGDLQKARRKH-LDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGV---LDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYL
 ...|.|  ..||....  . ||.||||.||||||.|....  |.... ||.   .|.. . ..|| ||||.|  ..||| .|||.| .|
eelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell

0039614 (Phosphotyrosine protein) phosphatases II 308-574 3.2e-69 229.0 In-house 24-291 (297) alignment
Range on Protein: 308-574
Range on HMM: 24-291/297.0
EKVAGTGMTGLEREFQLLNGAVPDelsdFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDK-EDTTYINASYLEGYQE-KVAFIATQAPLDNTIEDFWR
 .   ...|.|..||. |   .||    ...|  |.| .||||..|||....||.|  ...  .|..||||||..||   . .|||||.||..|.|||||
llekansktllllefeellslkpd....ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwr

MVWHEEVFCIVMLCGLNEPLE---VFFSAIYTylcWWGG---GRWTLKKTNGVIVSEINFNPkTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKA
|||.. | .||||. |.|       ...   .    .|.      . .. .|..| ...  . .||.|.. || |. | .| ||  | ......  ...|
mvweqgvtvivmLtklvelgrkcaqywpeegg...tygdftvtllkvehldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslellleflelvrea

RRKH-LDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYLDS
...   ..||.||||.||||||.|....  ||... || .||. . ..|| ||||.|  ..||| .|.|.| .|  
laelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr

0043336 (Phosphotyrosine protein) phosphatases II 302-572 1.1e-68 227.1 In-house 6-277 (278) alignment
Range on Protein: 302-572
Range on HMM: 6-277/278.0
RLMQLAEKVAGTGMTGLEREFQLLNGAVPdelSDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIE
.|... ...  .. |.|..||. |.   .    ....|  |.| .||||..|||....||.|  ..  .|..||||||..||. . .|||||.||..|.|
dllkallelllnlktllllefeellsfkl...dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetve

DFWRMVWHEEVFCIVMLCGLNEplevffSAIYTYLCWWGGGRWTLKK----------TNGVIVSEINFNP-KTGEVRQISHFMYLEWTEHAVPTKLLTII
|||||||.. | .||||..| |          ..  .| || .| ..           ....|  ..  . ..||.|.. |. || | .| ||. | ...
dFwrmvwelgvttivmLtelve......lgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslslll

DLIGDLQKARRkHLDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYL
|.. ....|.. . . ||.||||.||||||.|..|.  ||... || .|.. . ..||.||||.|  ..||| .|||.| ||
dflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 9-294 2.2e-68 225.3 In-house 2-285 (287) alignment
Range on Protein: 9-294
Range on HMM: 2-285/287.0
IPVAELKQHYLRMHANSDLLFEKEYKDIKE----PVNVTTRHCDNliNKPKNRYGNIKAYDHSRVILSsvqgdSESTDYINANWIDGFKQEKKYIATIGP
||| .. .   . ||...  |.. .. ...    . .||     .  ||.|||. .|  .|  ||.|       |  ||||| .|||.|..|..|.. .|
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasq..nkdknRltqilvpdnyrvllk.....gehpdyinavfidgykekkafiiaesP

KAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEEN-EQYGEIIVTLEEKEELADFEIRKFFLRKLSNQMETRMVKHFYFTSWPDHD-VPEYAT
 ..|  .||....... ...|||... |. . .|..|||||.   .||  ..| ..|  |.. .||. ... ... ....|| . .|.|...  |.|..|
mfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqt

GLLEFWKRVRNSWEgPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEI
 || . .....    .  ..| ||||..|||...|. ..  ... |.|  .||.. . . | |.  .||  .|| ||  ..|| .. ..|  
illvieemyktqrk.rgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetys

DSPc_SM00195 318-572 1.3e-67 223.3 In-house 2-262 (263) alignment
Range on Protein: 318-572
Range on HMM: 2-262/263.0
LEREFQLLNGAVPDElsDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVM
|..||. |. . ...  .. .| ..||..|||| ||||... || |. ...||...||||.|..|...| ..||||.||..|.||||||||.|.| .|||
lkeefekleestspk..etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

LCGLNEP----LEVFFSAI----YTYLCWWGGGRWTLKKTNGVIVSEINFNPKT-GEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKHlDRPV
|.  .|      . ..        |.       ... || . .|. ... . ..  | |.. .. | .|..| || .   ...|.  ..| ...  . |.
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpi

VVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYL
|||||.||||||.|.|.   |.... |  .|.| . ..||.||||||. |.||. .|||||.|.
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 318-572 1.3e-67 223.3 In-house 2-262 (263) alignment
Range on Protein: 318-572
Range on HMM: 2-262/263.0
LEREFQLLNGAVPDElsDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVM
|..||. |. . ...  .. .| ..||..|||| ||||... || |. ...||...||||.|..|...| ..||||.||..|.||||||||.|.| .|||
lkeefekleestspk..etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

LCGLNEP----LEVFFSAI----YTYLCWWGGGRWTLKKTNGVIVSEINFNPKT-GEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKHlDRPV
|.  .|      . ..        |.       ... || . .|. ... . ..  | |.. .. | .|..| || .   ...|.  ..| ...  . |.
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpi

VVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYL
|||||.||||||.|.|.   |.... |  .|.| . ..||.||||||. |.||. .|||||.|.
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_CG7180_pd Subfamily CG7180 23-288 6.3e-67 220.3 In-house 13-291 (296) alignment
Range on Protein: 23-288
Range on HMM: 13-291/296.0
ANSDLLFEKEYKDIKEPVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDSESTdYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSS
 .  .....|.| ...  . . ..  .. |. |||. ..  ||. ||.|....|...|  |||| ..|.| ..|.|| | .|| ||  .|||.......|
rkfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksd.YinavyvdsflkkkeyivteapkketvdefWrlvydeeis

IVVMLTKLVEKGKvKCHKYWPEE-NEQYGEIIVTLEEKEELADFEIRKFFLRKL---------SNQMETRMVKHFYFTSWPD-HDVPEYATGLLEFWKRV
 ||.|||  .  | ....|||.. .||||||.| . |....|...||.| | |            ..|||.||.| .| |.  . ||  ...|.|. .||
avvvLtktfdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrv

RNSW----EGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVT
|       | |. ||. |..| |..|.| .. ||| .|....|. .||. .| ..| .|. .|.   .| .|   ||||| 
rlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl

subfamily_PTPN13_pd Subfamily PTPN13 30-287 1.3e-66 219.7 In-house 14-269 (273) alignment
Range on Protein: 30-287
Range on HMM: 14-269/273.0
EKEYKDIKEPV-NVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGdsestdYINANWIDGF--KQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVM
..|.|...|     |..   .  || |||| |.  ||..||.|..  |      ||||..|     |.| .|||. ||  ||..|||.|.|| |.....|
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg......yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviam

LTKLVEKGKVKCHKYWPEENEQ----YGEIIVTLEEKEELADFEIRKFFLRKLsNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEgpQSGP
.|. .||||||||.||||....    .. . |.|.. ..| .| .|.. .... .  |.| | |. |..||||.||  |. ||.| ..||.  .  ..||
vtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkds.esgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagP

ITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAV
| ||||||.||.||.|.||.... |. .. .||   | ..| ||. .||   || |.. |.||..
ivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 45-286 1.7e-66 219.0 In-house 13-263 (270) alignment
Range on Protein: 45-286
Range on HMM: 13-263/270.0
RHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDSEsTDYINANWIDGFKQ-EKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWP
   .   .|  ||| .|    ..||.|.... ||. | |||||.. ||.. .|||||. ||.. |...||||.||.|.. .||.|.|.|||. || .|||
dlpeaargkklnRyadiLPsPatRvrleeleedsa.taYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWp

EENEQ-----YGEIIVTLEEKEELADFEIRKFflrKLSNQMETRMVKHFYFTSWPDHDVPEYAT------GLLEFWKRVRNSWEGPQS-GPITVHCSAGV
.|...     .|.| |. ...|    . ...    .| .. |.| . ||....|||| ||. .        ||.  . ||.| .  .  .|. |||||||
aepkekvkledgkikvlalseekeegyiltrl...rleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGv

GRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEA
|||||.|..| ... ..|.. .|| . ....| .|  .|| | || |.. |..| 
gRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavvey

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 6-325 4.7e-65 214.5 In-house 1-274 (392) alignment
Range on Protein: 6-325
Range on HMM: 1-274/392.0
RQPIPVAELKQhYLRMHANSDlLFEKEYKDIKEPVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVqGDSESTDYINANWIDGFKQEKKYIATIGPK
|||||||..   ..     |  || .|..|. .|    .. . . ||..||||.||  || .||.|  .  |.  .||.|| .|..|..|| |||. ||.
rqpipvaqfpa.fveknrhsa.lffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvklevi.ddipdsdylnasyipsfdnekayiasqgpn

AETTSDFWRMMWEHKSSIVVMLTKLVEKGkvkchkywpeeneqygeiivtleekeeladfeirkfflrklsNQMETRMVKHFYFTSWPDHDVPEYATGLL
| . .|||||..... . ..|.||| |                                            .  ..| |  |.|| |||.|||.... ||
aaslddfwrmvfqenvttiamvtklkegd..........................................kgddartvaqfhftewPdkdvpkhtssll

EFWKRVRNSWeGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLRMRLMQ
.| | |.  . |  . |. .||||||||||  | ||... . |.  ..||. .|. || .| .|||   ||.||. |.|| . . .| | |  .  .| .
kfikevkadf.Gqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqd

LAEKVAGTGMTGLEREFQLL
|   . | . .   .||. |
lstssdGdvrskqlkefrsl

subfamily_PTPN1_pd Subfamily PTPN1 28-295 7.2e-65 213.6 In-house 7-281 (290) alignment
Range on Protein: 28-295
Range on HMM: 7-281/290.0
LFEKEYKDIKEPV-NVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGdsestDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVM
|... |.||..   ...||....  |...||| ... |||||..| . .      |||||. ..  . ...|| | || ..|.. ||.|.||.||  |||
lykeiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn.....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvm

LTKLVEKGKVKCHKYWPEENE----QYG--EIIVTLEEKEELADFEIRKFFLRKLSNQmETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWE-GPQ
| |.|||...||..|||...|    ..   .. |.| ..|.   . .|.. | .|. | ||| . ||..|.|||  |||  . .|.|  .||.|    ..
lnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktq.etreilhfhyttwpdfgvpespaaflkflfkvresGslssd

SGPITVHCSAGVGRTGTFIVIDAMMEQI---KEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTF--GDTEIE
 ||  .|||||.||.|||...|... .|   .. . .|.   .  .| .|  ..| . |  | . |.|| . .  ||. ..
vGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdssvq

0040439 (Phosphotyrosine protein) phosphatases II 335-572 3.2e-62 205.7 In-house 2-246 (249) alignment
Range on Protein: 335-572
Range on HMM: 2-246/249.0
DFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEPlevffSAIYT
....|  |.| .|||||.|||....||.|  .|. ... ||||||..||. | .|||||.||..|.||||||.|.. . .||||. | |.       .  
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvel.....grekc

YLCWWGGGRWT----------LKKTNGVIVSEINFNP-KTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKH-LDRPVVVHCSDGVGRTGAF
.  |  || ..           .. ....| ..   . ..||.|.. |. |. | .| ||  . ...|.|  ..||...   . ||.||||.||||||.|
aqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtf

CTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYL
....  ||... |. .|.. . ..||.||||.|  ..||| .|||.| .|
iaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 339-577 8.4e-62 203.6 In-house 4-247 (250) alignment
Range on Protein: 339-577
Range on HMM: 4-247/250.0
ATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEPLEVfFSAIYT--YL
| .|.| .|||| .|.. . .||||      ... |||||.|.||.|. ||||||.|| .|||||||||..|..  ||||  |.|  .. ..  .     
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPveka

CWWGGGRWTLKKTN---GVIVSEINFNPK-TGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKHLDRPVVVHCSDGVGRTGAFCTLFATLERV
  .|. . .|....    ... ..    .   . |.. .. .. | . .|| .  ....|. ..|. ...  ..||.|.|| ||||.|||... | |||.
ekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerl

KLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYLDSFEE
| | |.|||   ..||..||..|  |.||  .||.|| .|||.|.
kkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsved

Y_phosphatase Protein-tyrosine phosphatase 344-569 9e-62 203.9 Pfam-A 1-234 (235) alignment
Range on Protein: 344-569
Range on HMM: 1-234/235.0
NSKKNRYPNILPCERCRVVLPAIPDKEDttYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEP----LEVFFSAIYTYLCWW
|.|||||..|||... || |   ....|  ||||.|..||.|| .|||||.||..||||||||||.|.| .||||. |.|     .. ...      .  
nkkknRykdilpydktrvklkgsegpsd..YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GGGRWTLK-K----TNGVIVSEINFNPKTGE--VRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARrKHLDRPVVVHCSDGVGRTGAFCTLFATLERV
|  . .|| |    .......... . |..|   |..... | .|..| ||..   ..||| ...| . .. . |||||||.|||||| |..| . ||..
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

KLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAIL
. |. .||. . ..||.||||||. |.||  .|.|||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 344-569 9e-62 203.9 In-house 1-234 (235) alignment
Range on Protein: 344-569
Range on HMM: 1-234/235.0
NSKKNRYPNILPCERCRVVLPAIPDKEDttYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEP----LEVFFSAIYTYLCWW
|.|||||..|||... || |   ....|  ||||.|..||.|| .|||||.||..||||||||||.|.| .||||. |.|     .. ...      .  
nkkknRykdilpydktrvklkgsegpsd..YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GGGRWTLK-K----TNGVIVSEINFNPKTGE--VRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARrKHLDRPVVVHCSDGVGRTGAFCTLFATLERV
|  . .|| |    .......... . |..|   |..... | .|..| ||..   ..||| ...| . .. . |||||||.|||||| |..| . ||..
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

KLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAIL
. |. .||. . ..||.||||||. |.||  .|.|||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykail

subfamily_PTPRA_pd Subfamily PTPRA 336-571 6.5e-61 201.0 In-house 50-294 (330) alignment
Range on Protein: 336-571
Range on HMM: 50-294/330.0
FYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEPLEVFFSAIYTY
. .|.. .| .|||..|||| .  ||.|. .  .|.. |||||...||.||  |||.| |...|.||||||.|  .   ||||  |.|  |      .  
lelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPd

LCWWGGGRWTLKKTNGVIVS----------EINFNPKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKHLDrPVVVHCSDGVGRTGAFCTL
   .  |  ...  . ...           ... . .  ..|... | .  | .  ||..   ...|.  ..| .... . |.||||| ||||||.|..|
eGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivl

FATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAY
 | ||||| |...||| . . ||.||| ||  . || ..|...| |
davlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 315-576 7.8e-61 200.9 In-house 21-287 (305) alignment
Range on Protein: 315-576
Range on HMM: 21-287/305.0
MTGLEREFQLLNGAvpDElsDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFC
 .||| ....|     .|   .   .. .| .|||. .| . .  |. | . ....|. ||||||..||..| ..|..|.||.||..||||....| |  
dkgleaqykslyee..ee..sidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvst

IVMLC----GLNEPLEVFFSAIYTYLCWWGGGRWTLKK---TNGVIVSEINFNP--KTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKHLD
||||.    | ..  . ..    |.   .|    .||    ... |  ...     .  | |.....   .| .| ||..  ....|| ..||...|  .
ivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkg

RPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYLDSFE
 |..||||.||||||.|...   |||.| |.|.|||   . ||..|..||. ||||  ...|.  .. ...
vpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgd

subfamily_PTPN23_pd Subfamily PTPN23 25-287 1.3e-60 199.7 In-house 13-280 (288) alignment
Range on Protein: 25-287
Range on HMM: 13-280/288.0
SDLLFEKEYKDIKEPVNVTTRHCDNLI---NKPKNRYGNIKAYDHSRVILSsvqgdSESTDYINANWIDGFKQE-KKYIATIGPKAETTSDFWRMMWEHK
    ..|..|....  .  .|.    |   .  |||. .|  |||.|| |      ..  ||||| .. .      ..||| .|...| .|||.|..| |
gktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr.....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqk

SSIVVMLTKLVEKGKVKCHKYWPEENE---QYGEIIVTLEEKEELADFEIRKFFLRKLsNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRN---S
||..|||..  |.|| |...||||...   ..|.. |||....|.  .  |.. |. | .. ....|.|  .||||.. ||.    ||.| . |..   .
ssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletl.dadavksvshlqltsWpelGvPasPetllqfldevesayea

WEGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEEN-LLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAV
 . .   |. |||||||||||.| .. | .......| |||.   |||.|.|| ||||  .|. |   | |||.
vqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa

0042113 (Phosphotyrosine protein) phosphatases II 338-572 1.4e-60 200.1 In-house 3-243 (245) alignment
Range on Protein: 338-572
Range on HMM: 3-243/245.0
TATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEplevfFSAIYTYLC
.|  |.| .||||..|||....||.|. ..  .|..||||||  ||. .  |||||.||..|.||||||.|.. . .||||. . |     .. .  .  
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeee.....lgrvkcaqy

WWGGGRWTL----------KKTNGVIVSEINFNP-KTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKHLDRPVVVHCSDGVGRTGAFCTLF
|  |. .|           .. ....| ...  . ...|.|.. |..|| | .| ||. | ...|..  ..||.... . ||.||||.||||||.|....
wplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaay

ATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYL
  ||... |. .... . ..|| ||||.|  ..||| .|||.| .|
lmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 28-299 1.6e-60 199.4 In-house 10-278 (283) alignment
Range on Protein: 28-299
Range on HMM: 10-278/283.0
LFEKEYKDIKEPVNVTTRHCdNLINKPKNRYGNIKAYDHSRVILssvqgDSESTDYINANWID---GFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIV
|| . .| .  |   .. .. .  ||.|||. .| ..|  || |     .||| ||||| .|      ||.||||.. .|  .|  |||.|....| . .
lfrevlkrlsvpdldadias.adenkrknrnqeivpadqwrvel.....ksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitai

VMLTKLVEKGKVKCHKYWPEE-NEQYGEIIVTLEEKEELADFEIRKFFLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGPqSGPI
|||||| |  ..|| .|||..  |.|||  |||..      | |... ||. |   .| .. |. .  | . .       |. | | . .  | .  |||
vmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqtesk.kgPi

TVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNL
 ||||.|.|||..|| . | ..... | ..||.. |  .| ||  .||   || ..| . ||    |||.|   .|
vvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdl

0045098 (Phosphotyrosine protein) phosphatases II 330-572 1.8e-58 193.4 In-house 22-272 (278) alignment
Range on Protein: 330-572
Range on HMM: 22-272/278.0
PdelSDFYTATQPKNSKKNRYPNILPCERCRVVlpaipdkeDttYINASYLEGYqeKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEPLE---
|   |....|  ..| .||||..|||....||.        |  ||||||..||  . .|||||.||..|..|||||.|.. . .||||..| |      
p...seitpalylgnldknRykdilpydhsrVk........d..YINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekc

----------------VFFSAIYTYlcwwgggrwTLKKTNGVIVSEINFNPKTGEVRQISHFMYLEWTEHAVPTKL--LTIIDLIGDLQKARR-------
                | .  ....             .   .|  ........| | . |. || | .| ||.      ...|.  ...|..       
aqywpeggsltygdftvtllseevl.........ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslll

-----KHLDRPVVVHCSDGVGRTGAFCTLFATLERVklEGVLDVFITARMLRTQRPG-MVSHLDQYRLCYEAILAYL
        . ||.|||| ||||||... ..  ||..  ||..|.. . ..||.|||| .| .|.||| .||..| .|
sslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 30-284 2.2e-58 192.3 In-house 17-274 (287) alignment
Range on Protein: 30-284
Range on HMM: 17-274/287.0
EKEYKDIkEPVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSvQGdSESTDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTK
..  .|  | . .| .  ..| .  ||||...  .|..||.||  .|    .||||||.. ........||. || | |  ||||...|..|. |...|.
dalkeds.esstatfkaaeelaavkknryadvlPiddtrvllsa.eg.elGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtr

LVEKGKVKCHKYWPEENEQ---YGEIIVTLEEKEELADFEIRKFFLRKLSNqMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRV----RNSWEGPQSGP
 ||... ||.||||| .      |  .| |. .    .. .| . | .|    |.|.|| . . ||||. ..  | ||. |   |      . .. . ||
eveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidlet.rearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGP

ITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALL
. ||...|.||.|... . ..... ..   .||   | |.| .|. .|| . |. ..  || 
lvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv

subfamily_PTPRN_pd Subfamily PTPRN 19-287 3.3e-58 191.7 In-house 21-292 (297) alignment
Range on Protein: 19-287
Range on HMM: 21-292/297.0
LRMHANSDLLFEKEYKDIKEPVN--VTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGdSESTDYINANWI-DGFKQEKKYIATIGPKAETTSDFWRM
|. | .    .|||.. ...  .   |.  ...  |  |||. .. .|||||| |.. .  .|..|||||  | |   ..  |||| || |.| .|||.|
ledhlknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeas.aeksdyinasaildhdprapayiatqgplastvadfwqm

MWEHKSSIVVMLTKLVEKGKVKCHKYWPEENE-QYGEIIVTL-EEKEELADFEIRKFFLRKLSNQmETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRN
.||. . ..|.||.| |.|  .|..|||.| .  |.   | |  |.    |. .| |.|. | .. ||| |  |.| |||...||  |  |||| ..|  
vweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqts.etrtvtqfhflswpeegvPasaksllefrrkvnk

SWEGpQSGPITVHCSAGVGRTGTFIVIDAMMEQI-KEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAV
|. | .| || ||||.|.||||..|.|| ..... |  . .|. . .  .| ||. .|.  .|. |.  |. | |
syrG.rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 312-577 1.3e-57 189.9 In-house 16-288 (290) alignment
Range on Protein: 312-577
Range on HMM: 16-288/290.0
GTGMTGLEREFQLLNGAVPDelSDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKED--TTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWH
 .|..| . .|. |. .  .     .... ..|...||. ||.. .  |..|  |....|    ||||.|..||.|| ..||||.|. ||. |||...|.
akgnegfrnqfkmldsgese..htvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwq

EEVFCIVMLCGLNEPLEVFFSAIYTYLCW--WGGGRWTL---KKTNGVIVSEINFNPKT--GEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRK
|.| .||||.  .|  .|     ..      .|  . .|   ...|. |  ... . |.  |. ... ..    | ..   |.  ||. .|   .| .||
ekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrk

HLDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYLDSFEE
. ....||||||.|||.. ||..  |....| ||| |||   . .|.|.||.|   .||.. .. .| |||||| 
rgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfet

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 305-572 1.4e-57 190.0 In-house 10-279 (288) alignment
Range on Protein: 305-572
Range on HMM: 10-279/288.0
QLAEKVAGTGMTGLEREFQLLnGAVpDELSDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFW
. . |   .. ||...|.. |  |. .. ..  .. ...| |||||.|||| .  || |   ...... ||||||..|...| ..||||.|| .|..|||
akvakksarnrtgfseeynsL.aal.ektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfW

RMVWHEEVFCIVMLCGL----NEPLEVFFSAIYTYlCWWGGGRWTLK---KTNGVIVSEINFNpKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQ
..|. ...  |||| .|    ..  | .. .  .    .|    ||.   ... ... ..  . |... ..| .. || |..| ||     ...|.  ..
elvyenktstivmltelveggktkCeeYWPdadkp.knyGsvtvtlveskeledfvlrkllle.kkkteleitqyqylaWpdhgvPeskapllellrqvk

KARRKHlDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYL
 |  .    |..||||.|||||| | .| | ...|. | ..||. |   || ||. .|  | ||  .||..|   
vanqad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 305-577 3.3e-56 185.4 In-house 9-283 (287) alignment
Range on Protein: 305-577
Range on HMM: 9-283/287.0
QLAEKVAGTGMTGLEREFQLLNGaVPDELSDFYTATQPKNSKKNRYPNILPCERCRVVLPaipdKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFW
....|   .| .| .  |..|.  | ..  .   .  ..| .|||. .||. .  ||.|     .|.  ||||....||.|| |||....|. ||. .||
efvakghakgnegfknqftvleq.vtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfW

RMVWHEEVFCIVMLCGLNEPLEvffSAIYTYLCWWG---GGRWTLK-----KTNGVIVSEIN--FNPKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIG
.......|  ||||| ..|  |   .. | |         | ....     ...|.|. ...   . |.|. .|.  . . .| ..   |.  ||. .| 
kliddrnvtaivmlcqekende...evcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvie

DLQKARRKHLDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYLDSFEE
.  |..||. . ..||||||.|||.. ||    |....| |||.|||   .  | |.||.|   .||.  ....|.|||||| 
emyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfet

subfamily_PTPN14_pd Subfamily PTPN14 18-285 6.1e-56 184.6 In-house 15-294 (300) alignment
Range on Protein: 18-285
Range on HMM: 15-294/300.0
YLRMHANSDLLFeKEYKDIK-EPVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDseSTDYINANWIDGF--KQEKKYIATIGPKAETTSDFWR
 | .. ..  .| .||  |. .  . ..  . .  |..|||. ..  |...|| ||. . .  ||.||||  |      .|..||.. ||   |  |||.
ilekkleegkvf.teyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken..stgyinassikvsvggkersyivaqgPleltvqdfWq

MMWEHKSSIVVMLTKLVEKGKVKCHKYWPEE-----NEQYGEIIVTLEEKEELADFEIRKFFLRKLSNQmETRMVKHFYFTSWPDHDVPEYATGLLEFWK
|.||.. ...||||.  |.|| |..||.|..     . ..|.  || . .|.   .  ... |. |  . | | | |. .| ||||.|||  .| |.. .
mvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpsk.eertvwhlqytDWpdhgvPeDvkgflsyLe

RV---RNSWEGP-----QSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLE
.|   |.  .       .. |. |||||||||||  |. | ... .. .. .|. . ..|.| || ..||  .|| |.. .|..
evqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlik

subfamily_PTPRB_pd Subfamily PTPRB 335-577 3.3e-55 182.2 In-house 42-290 (293) alignment
Range on Protein: 335-577
Range on HMM: 42-290/293.0
DFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEPLEVFFSAIYT
   .|....|..|||| |||| .  || | |. |.... ||||.|..||. .  ||||| || .|..||||||| ...  ||||  | |   |     . 
avkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWP

---YLCWWGGGRWTLK---KTNGVIVSEINFNPkTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKAR-RKHLDRPVVVHCSDGVGRTGAFCTLFA
     . .|  . ||.   ...  .. |.. .  . | |.. .. .. |..| || |  |..|..  ...|  ... .||.||||| ||||||.| .|  
adeepvlyGdikvtlvaeeeledwvirelkiek.ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdr

TLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYLDSFEE
 |.... | ..|.| .   ||..|  .|   .||   ....|..| . ||
llqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkkee

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 13-292 5.6e-55 181.2 In-house 4-298 (301) alignment
Range on Protein: 13-292
Range on HMM: 4-298/301.0
ELKQHYLRMHANSdllFEKEYKDIKEPVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQG-DSESTDYINANWIDGFKQEKKYIATIGPKAETTSD
.|..|   .|.|.   ||..||..||  . ..    .  ||. ||. ||. ||. |.||.  .  |. ...||||..|||....||.||. ||  .|  |
dlgthvaakhsnk...feeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvd

FWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPE---ENEQYGEIIVTLEEKEELADFEIRKFF------------LRKLSN--QMETRMVKHFYFTSWPD
|||..|..| . .||.|.| |. | ||..|||.   |.|..|.. ||| ..  . || ||..              ||.    ..... |  .  |.||.
fWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpq

HDV-PEYATGLLEFWKRVRNSWEgPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDT
. | .|..| |    . .   .  .  ||. ||||..|.|.|... ..  .|| | |   ||.  . ..| ..  .|.   ||..|. .. . ... .|
dGvvreprtvLqviddvihrqqk.igggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnst

0041856 (Phosphotyrosine protein) phosphatases II 52-294 6.1e-55 180.9 In-house 1-178 (182) alignment
Range on Protein: 52-294
Range on HMM: 1-178/182.0
NKPKNRYGNIKAYDHSRvilssvqgdseSTDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTklvekgkvkCHKYWPeeneqyge
|..|||| .|  |||||             ||||||...|    ...||| ||  .|. ||.||..|.. ...|.||         .. |||        
nldknrysdilpydhsr...........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp........

iivtleekeeladfeirkfflrklsnQMETRMVKHFYFTSWPDHDVPEyATGLLEFWKRVRNswegpQSGPITVHCSAGVGRTGTFIVIDAMMEQikeeN
                          . ..|.. ......||||.||.    ||.| ..|..     ..||. ||||||||||||..... |...    .
..........................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g

lLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEI
 ..... |. .| .|. ||..|.|| |...|||| . ...|..
.vsleeavklvrsrRpgmvitpnqyfflqlallellllkktrp

subfamily_PTPN12_pd Subfamily PTPN12 338-573 1.2e-54 180.1 In-house 34-278 (290) alignment
Range on Protein: 338-573
Range on HMM: 34-278/290.0
TATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEP----LEVFFSAIY
......| ||||| .||| .  ||.|  | ..|.  ||||....| ..|...||.|.|| .|..|||||.|. .|  .||.| . |      | ...   
agekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeeg

TYLCWWGGGRWTLKK----TNGVIVSEINFNPKtGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRkHLDRPVVVHCSDGVGRTGAFCTLFATL
   . .|  . ||..    ... ..  .. . . .| |..  | | .| .| ||..  ....|| .... .. . | |.||||| ||||||. ...  . 
eeelefgefevtleeekavdddflirtLkveaq.kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvr

ERVKLEGV---LDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYLD
| .| | .   ||||   . ||.||. .|   .||.| |.|.. .. 
ellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 289-570 5.3e-54 178.7 In-house 6-289 (319) alignment
Range on Protein: 289-570
Range on HMM: 6-289/319.0
FGDTEIEVQNLRMRLMQLAEKV-AGTGMTGLEREFQLLNgAVPDELSDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKV
||.... |.....  .||. |  .   .| || ||. .   .. .|.|   |  ..|  |||. |||. .. .| |  .  .| . |||||...||| | 
fgesdvavpdfpayyqqlsnksdfdddltklevefrrac.klgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkd

AFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCglNEPLEVFFSAIYTYL-CWWGGGRWTLKKTNGVIVSEINFNP--KTGEVRQISHFMYLEWTEHAVPT
 .||.| |||||..|||||.|  ..  ||.|   ..    ..                ....|.  .| .|.     |  ..|.|  | .| | .. || 
kyiaaqGPldntladfWrmiweyncstivllt..kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpd

KLLTIIDLIGDLQKARRKH-LDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILA
    .. |.  ... ..|    ...||||| ||||||.. .| . |.|.| |  .||. . | || ||. .| .| || ..| |.| 
ypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 342-573 2.6e-53 175.9 In-house 26-269 (274) alignment
Range on Protein: 342-573
Range on HMM: 26-269/274.0
PKNSKKNRYPNILPCERCRVVL-PAIPDKEDTTYINASYLEGYQEK-VAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEPLE----VFFSAIYTY
.....|||| .||| |. ||.| .. ...||..|||| |. ||.|.  |..||| || ||..|||||...|||  ||||  |.|  |    |.|     |
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

--LCWWGGGRWT---LKKTNGVIVSEINFNPKTGeVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKHLDR--PVVVHCSDGVGRTGAFCTLFAT
     .|.   .    ...|.  | ..  .  .   |.. |..| .| .| .| .  |..||. . ...|...  .  ||||||| |.||||.| .   .
eiserygdveikvekiverndysvrklvlkyler.ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisia

LERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYLD
. ... |.|.||. .   || .| |||   .||.| ..|.  || 
vrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk

0051429 (Phosphotyrosine protein) phosphatases II 81-289 3.3e-53 176.3 In-house 4-226 (272) alignment
Range on Protein: 81-289
Range on HMM: 4-226/272.0
TDYINANWIDGFKQ---EKKYIATIGPKAETTSDFWRMmWEHKSSIVVMLTKLVEKGKVKCHKYWP-------------EENEQYGEIIVTLEEKEELAD
..||||....|. .   ....... ||   |  ||||. .|.. . .|.|....|.|..||..|||             ..   || . ||| ..| | |
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

FEIRKFFLRKLSNQMETRMVKHFYFTSWPDHDVPEYAtgLLEFWKRVRNswegpqSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLD--------VY
. .|.. |..|..  |.|.| |...|.|||| ||. |  |||. . ...      .||. ||||||..||||..... ..... .|  .|        ..
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyle

SYVSRIRAQRNFMVQRPSQYSFIHYALLEAvTF
 .|...||||  .|| . || |.. ||||.   
eaveelraqrpgavqteeqylflyeallel.lr

0037934 (Phosphotyrosine protein) phosphatases II 336-571 6.1e-53 175.2 In-house 2-241 (243) alignment
Range on Protein: 336-571
Range on HMM: 2-241/243.0
FYTATQPKNSKKNRYPNILPCERCRVVLpaipdkEDTTYINASYLEGYqEKvaFIATQAPLDNTIED----FWRMVWHEEVFCIVMLCGLNEPlevffsA
|..|  | | .||||..|||... ||.|      |.. ||||.. ... ..  .||||.||..|.||    ||||.|.. . .||||. | |        
fsiallpenlsknrysdilpydhsrvkl......egsdyinanliyvt.pr..liatqgPlpetveddlasfwrmlwelgitvivmltelvEl......g

IYTYLCWWGgGRWtlkKTNGVIVSEINFN--------------P-KTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRK-------HLDRPVV
 . .   |  | .     ....|  ....              .  ....|.. |..|| | .| ||.    ..|.. ....  ..       . ..||.
rekcaqywp.gev...tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvl

VHCSDGVGRTGAFCTLFATLERVkleGvLDVFITARMLRTQRPG-MVSHLDQYRLCYEAILAY
|||| ||||||......  |...   | .|.. . ..||.|||| .|  ..||| .|||.| .
VHCsaGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 332-570 8.3e-52 171.4 In-house 13-253 (284) alignment
Range on Protein: 332-570
Range on HMM: 13-253/284.0
ELSDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCglNEPLEVFFSA
...|   |  ..|  |||. .||. .. .| |  .  .| . |||||...||| |  .|||| |||||..|||||.|  ..  ||.|   ..    ..  
ngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt..kdkcsqywpl

IYTY-LCWWGGGRWTLKKTNGVIVSEINFNP--KTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKH-LDRPVVVHCSDGVGRTGAFCTLFA
              ......  .| .|.     |  ..|.|  | .| | .. ||     .. |.  ... ..|.   ...||||| ||||||.. .| .
kivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldv

TLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILA
 |.|.| |  .||. . | || ||. .| .| || ..| |.| 
lldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle

0036282 (Phosphotyrosine protein) phosphatases II 81-281 6.2e-51 167.8 In-house 2-164 (174) alignment
Range on Protein: 81-281
Range on HMM: 2-164/174.0
TDYINANWIDGFKQEKKYIATIGPKAettsdFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEeneqygeiivtleekeeladfeirkfflrklSNQME
.|||||...|..   ...||. || |     ||.|..|.....||||....|.|..||. ||||                                 . .
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lredl

TRMVKHFYFTSWPDHDVPEYATgLLEFWKRVRNSWEGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKeENLLDVYSYVSRIRAQRNFMVQRPSQYSFIH
.|.. ..... |||| ||. .. |||| |.|..  . ...||. ||||||||||||..... |. ... |.| |....| ..| ||  |||.|||| |..
erlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly

Y
|
y

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 308-572 2.5e-50 166.5 In-house 15-288 (325) alignment
Range on Protein: 308-572
Range on HMM: 15-288/325.0
EKVAGTGMTGLEREFQLLNgavPDELSDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMV
||       |. .||.||    .|.   . .|..|.| .|||..|... .. |||| .  |. .. |||||||. ...|  |.|.|||| .||.|.||.|
ekkkaqdqdgfahefgllp...sddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlv

--WHEEVfcIVMLCGLN---EPLEVFFSAIYTYLCWWGGGRWTLKKTNGV---IVSEINF-NPKTGEVRQISHFMYLEWT---EHAVPTKLLTIIDLIGD
  |.  |  .|.|  |.   .   |..         .|| .  |.  . .   .   ..  ..| || | .  | .  |     .  |. |..|..|.  
ldWrcsv..vvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvka

LQKARRK--HLDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYL
...  .   .   |..||||.||||||.| .|.. |..|  |  .|.|   . || .|| ||   ||| |.|||.  ..
vservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 316-571 1.8e-49 163.4 In-house 24-278 (315) alignment
Range on Protein: 316-571
Range on HMM: 24-278/315.0
TGLEREFQLLNGAvpdELSDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCI
 |...... . |    .|  . .| . .| .|||| ||.. .. || || .  .... |.||....||. |  .||.|.|. ....||||.|..|..  |
ngfkqdyesipgg...qlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigki

VMLCGLNEPLEVFFSAiYTYLCWWGGGRWTLKKTNGVIVSEINFN----PKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKHLdRPVVVH
||| .| |  .      |        |. |. . .  . .|.           ..|..  . |  | .  ||   .....||   .. . .    ..|||
vmltnlvegekrkaek.ywpdkkviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvh

CSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAY
||.||||||.|.|| | |.... | ..||.   . .| .| .||. ..||.. |.|.|  
csaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydallet

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 335-577 4.2e-49 162.3 In-house 39-289 (297) alignment
Range on Protein: 335-577
Range on HMM: 39-289/297.0
DFYTATQPKNS---KKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEkvAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEPLEV----
  ...|. ..    .|.|| |||| .. || |  . |. |  |.|||...|...   .|.|| | ..|..|||.||..|.|  ||||  .||  .     
niqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcary

FFSAIYTYLCWWGGGRWTLKKTNGVIVSEINFNPKTGE-VRQISHFMYLEWTEHAVPT--KLLTIIDLIGDLQKARRKHLDRPVVVHCSDGVGRTGAFCT
..    | .        .... .| |  |.. .       | .  . ..|| ..||.   .  ....|| ...|   .. . |..|||. |||||| ..|
WsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvllt

LFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYLDSFEE
.   . ..| |  .|.| . ..|| .|| .|   .||.. |.|.| .| | . 
idsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedt

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 337-573 5.4e-49 161.7 In-house 37-278 (315) alignment
Range on Protein: 337-573
Range on HMM: 37-278/315.0
YTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEPLEV----FFSAI
 .| .. | ||||| |||| .. ||.|  | |. |  ||||||......  |.||.|.||. ...||||||..|.|  |||.  ..|   .    ..   
rvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdr

YTYLCWWGGGRWTLKK---TNGVIVSEInFNPKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLqKARRKHLDRPVVVHCSDGVGRTGAFCTLFATL
 . .  .|  . .| .   . . .. ..    |. | |... | . || .. |. .. ... || .. || ... . ...|||| |||||| ....   .
kadsvefGsikvellsleadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqtssllklikev.kadngkkefsllvhcsaGvGrtGvvisidevv

ERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYLD
...| . ..||| . ..||..|| .|   ..| . |.|.| .| 
aqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll

subfamily_PTPN23_pd Subfamily PTPN23 312-573 1.3e-48 160.3 In-house 11-281 (288) alignment
Range on Protein: 312-573
Range on HMM: 11-281/288.0
GTGMTGLEREFQLLNGAVPDELSDFYTATQPKNSKKNRYPNILPCERCRVVLPaipdKEDTTYINASYLEGYQEKV-AFIATQAPLDNTIEDFWRMVWHE
  | |.|...|..|. .   |  .. .|   ..|.|||. .||| .. ||.|     ..   |||||....       ||||||||..|. |||.||...
ldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeq

EVFCIVMLCGLNEPLEV----FFSAIYTYLCWWGGGRWTLKK---TNGVIVSEINFNP-KTGEVRQISHFMYLEWTEHAVPT---KLLTIIDLIGDLQKA
 .  ||||   .|  .     .. .       .|  . |||.   |. ..  ... .  .. .|...||  . .|.|. ||    .|| ..| . .  .|
kssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayea

RRKHLDRPVVVHCSDGVGRTGAFCTLFATLERVK-LEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYLD
...... |.||||| ||||||.|. ..| .. ..  .|.||.    . ||.||  ||.. .|.. .|||.| .  
vqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaar

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 39-285 1.6e-47 157.0 In-house 30-275 (307) alignment
Range on Protein: 39-285
Range on HMM: 30-275/307.0
PVNVTTRHCDnlINKPKNRYGNIKAYDHSRVILSSvqgDSESTDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKC
|  ||.   .   |  |||| ..|. |..|...     |  ..||| ||..    . ||.|.. ||. .|  .|| |. ..|   |.|| |..| .|.||
pegvtveafs..antdknryqdvkcqdkgrivvkf...dglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikc

HKYWPEENEQ---YGEI-----IVTLEEKEELADFEIRKFFLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNswegpQSGPITVHCSAG
..||| |. |   .||      .  |  |.   | .. .    |.    ..| ..|. .. |||. ||.   . ... . ||      .  |. ||||||
eqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry.....dtnpvvvhcsaG

VGRTGTFIVIDAMMEQ-IKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLE
|||.|| . |  .... |. .|  |.   |  .|.||.. .|   || ..|  |||
vGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlle

0049772 (Phosphotyrosine protein) phosphatases II 21-295 2.2e-47 157.7 In-house 15-288 (314) alignment
Range on Protein: 21-295
Range on HMM: 15-288/314.0
MHANSDLLFEKEYKDIKEPVNVTTRHCDNLINKPKNRYGNIKAYDhSRVILSSVQGDSesTDYINANWIDGFkqeKKYIATIGPKAETTSDF--------
.    .||..  . ..  ... |.  .| . |. |||| .|  .| .||||... ...  .|||||...|||   .|.||| ||. .|  ||        
hddllklllvlnrrslsvlpeltilvadlflnrdknryldilpad.nrvilpglpvsg..sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyy

--WRMM--WEHKSSIVVM---------------------LTKLVEKGkvkchkywPEENEQYGEIIVtlEEKEELADFeirkfflrklsnqmeTRMVKHF
  |||.  ..... ..||                     |..| ..|        .| .... | .   ||  .  .|               .|.. ..
ngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng........neptaadlellk..eelydpelf...............erlgiky

YFTSWPDHDVPeYATGLLEFWKRVRNSwegPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEeNLLDVYSYVSRIRAqRN---FMVQRPSQYSFIHYALL
. . .||...|     ..|| . ...    .. ||. |||.||.||||||.|.. .| . .  .| .....| ..|   |    ... . || ||..|||
lripvpDgsap.lledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRp.inpnpgfieqleqyefileall

EAVTFGDTEIE
|.. |  ...|
eylkflkkfye

0043147 (Phosphotyrosine protein) phosphatases II 79-281 1.8e-46 153.3 In-house 3-155 (172) alignment
Range on Protein: 79-281
Range on HMM: 3-155/172.0
ESTDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLvekgkvkchkywpeeneqygeiivtleekeeladfeirkfflrKLSNQ
|..|||||...|.    ...||| ||  .|..|||||..|.. ...|.||.|                                            .  .
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

METRMVKHFYFTSWPDHDVPeYATGLLEFWKRVRNSWEGPQSGPITVHCSAGVGRTGTFIVIDAMMeqikeeN-LlDVYSYVSRIRAQRNFMVQRPSQYS
 ..|.. ......||||.||  .  |||| . ...     ..||. ||||||||||||..... |.        | ...  |. .|..|. .|| |||| 
llerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqyr

FIHY
|..|
flyy

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 341-572 3.1e-46 152.5 In-house 40-276 (515) alignment
Range on Protein: 341-572
Range on HMM: 40-276/515.0
QPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEPLEV----FFSAIYTYL
.  | ||||| |||| .. || |  | |. .  |.||||.....   |.||.|.|.. ...||||.|..|.|  |.|.  |.|   .    ..  . .  
eeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgds

CWWGGGRWT---LKKTNGVIVSEINFNpKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLqKARRKHLDRPVVVHCSDGVGRTGAFCTLFATLERVK
  .|  .     |.   | |  ...   |  ..| .  | . || .. || .  ... || .. || . ..  |...||| |||||| ....   . ..|
vkfGsikvelvsleactggikrkltvl.kgddsrtvtqfhfteWPdkGvpkhtssllklikev.kadhgqythpliihcsaGvGrtGvvisidsvvahak

LEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYL
   ..||| . . .| .|| .|   .|| . |.|.| .|
ttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 52-285 5.2e-46 151.6 In-house 56-281 (290) alignment
Range on Protein: 52-285
Range on HMM: 56-281/290.0
NKPKNRYGNIKAYDHSRVILSsvqgDSESTDYINANWIDGFKQekKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEENEQ---
.  |||| ..   | .||||.    |    ||. ||...| |    .| | |. ..|. |.|||. ..| . .||| .|.|.|| ||..|.||.. .   
efkknrykdvvcndktrvilk....dGydGdyvhanyvkGlka..mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevlt

YGEIIVTLEEKEELADFEIRKFFLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSwegpqSGPITVHCSAGVGRTGTFIVIDAMMEQIK
.||| |.  |...  .  |.| .  .  ..    ..||.   ||||. |.  .  ||   . .|.      |||..||||||.||||||. |.. .. . 
fGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka.....sGpvvvhcsaGiGrtGtfvaievglqill

EENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLE
.   ||.   |  .|  |   ||   ||  .  .||.
dGkeldlldlvralrnsrlnsvqvdiqylalveilld

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 327-569 5.7e-46 151.7 In-house 18-263 (283) alignment
Range on Protein: 327-569
Range on HMM: 18-263/283.0
GAVPDELSDFYTATqpKNSKKNRYPNILPCERCRVVLPAIPDkedtTYINASYLE---GYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNE
 .|||  .|  .|   .| .|||. .|.| .. || | . .     .||||...     |...  .|..|.|||.|. |||.||..|.. .||||  | |
lsvpdldadiasad..enkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqe

PLEVFFSAIYTYLCWWGGGRWT--LKK---TNGVIVSEINFNPK--TGEVRQISHFMYLEWTEHAVPTKLLTIIDLiGDLQKARRKHLDRPVVVHCSDGV
 |..  |  .        | .|  |.|    |  |. |.  . .  . .   ..|. . .|.|    . . ... .   ..  .... . |.||||| |.
dlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkf.nkvislqteskkgPivvhCstgi

GRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAIL
|||..|... |... .. | |.||| . ...| ||...|  ||||.| .|..|
Grtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvl

0046846 (Phosphotyrosine protein) phosphatases II 76-284 1e-44 147.7 In-house 7-170 (176) alignment
Range on Protein: 76-284
Range on HMM: 7-170/176.0
GDSESTDYINANWIDGFkqekKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEENEQYGeiivtleekeeladfeirkfflrkl
|. .. ||||||.|.|     ..||| ||  .|. ||..|..|.. ..||.||..||.|..||. ||||. .                            
gldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.........................

snqmetrmvkHFYFTSWPDHDVPEYaTGLLEFWKRVRNSWEGPqsGPITVHCSAGVGRTGTFIVIDAMMEqikeENLLDVYSYVSRIRAQRN-FMVQRPS
          ..... ||||.||.. . |||. . .|.  .    ||. ||||||.|||||..... ..     |. |.|.  ....|.||  ..|| |.
..........qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpe

QYSFIHYALL
|| |.....|
Qyrflyefel

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 26-286 3.5e-44 145.8 In-house 5-258 (267) alignment
Range on Protein: 26-286
Range on HMM: 5-258/267.0
DLLFEKEYKDIKEPVNVTTRhCDN---LINKPKNRYGNIKAYDHSRVILSSVQGDsestdYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSS
.  .|||.. ||.  . ... .       |. .||. .   ||..||||.  . .     |||| ...|.|.....|.| .|   | .||. .. ..| .
eceiekefelikkisdtsst.isqsiaeknqernrlddnlpyddtrvilrtkeee.....yinasyvegyktknafivtqdplkntitdfltvihdqkvp

IVVMLTKLVEkGKVkcHKYWPEE---NEQYGEIIVTLEEKEELADFEIRKFFLrKLSNQMeTRMVKHFYFTSWPD-HDVPEYATGLLEFwkRVRNSWEGp
..|.|||  . ...  ...|| .    ..| .. |    ..|  |..|  . | |. |.  .. |  .|.  |    .   |   |.      .|  |  
vivlltkvft.dni..rlfwPPkmgqakkyqdltvehslekeendyqiitlel.kfknes.ahnvtlyyykkwnintnnkpylkplfgi..laknqlen.

QSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEA
 . |. |.||.||||.|||.|||...|..|.|. .|.. .. .|| ||  .|.   .| .||  | | 
gnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 337-571 8e-44 144.6 In-house 38-235 (392) alignment
Range on Protein: 337-571
Range on HMM: 38-235/392.0
YTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEPLevffsaiytyl
 .| .. | ||||| |||| .. ||.|  | |  |. |.||||..... . |.||.|.|   ...||||||..|.|  |.|.  |.|             
tvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...........

cwwgggrwtlkktngvivseinfnpKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLqKARRKHLDRPVVVHCSDGVGRTGAFCTLFATLERVKLEG
                         |  ..| .. | . || .. || .  ... .| .. ||   .  .|...||| ||||||   .. . . . |   
.........................kgddartvaqfhftewPdkdvpkhtssllkfikev.kadfGqythpliihcsagvgrtgvvisidsvvahakktr

VLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAY
..|||     .| .|| ||   .|| . | |.|  
mvdvfnfvtnirrkrpymvqtkeqyafiygavled

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 39-285 2.4e-43 142.8 In-house 25-267 (281) alignment
Range on Protein: 39-285
Range on HMM: 25-267/281.0
PVNVTTRHcDNLINKPKNRYGNIKAYDHSRVILSSVQGDSESTDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKC
| .. |   .. .|. |||| || . | ||| |     . .||||| ||.|     .. || | ||| || .|||||.|. ... .||| ...|  . ||
psdlctvf.nqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekc

HKYWPEENE---QYGEIIVTLEEKEELADFEIRKFflrKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNswegpQSGPITVHCSAGVGRTG
 .|.| .     |. .. |. |.      .   ..   .|| . |||.. |. .  ||| .||| .  .|.  ...|      .| |  .||||||||.|
aeyfprnahcclqfdklsvsyedstvnkslvttrl...nlsyegetrlithwlwkewpdwqvpessevmlkilrkira.....rstppvihcsagvgrsg

TFIVIDAMMEQIKEE-NLLDVYSYVSRIRA-QRNFMVQRPSQYSFIHYALLE
|.. ..  .. |.    | |.   ||..|   |   ||   || .|   ||.
tlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 319-570 5.3e-43 142.1 In-house 23-277 (439) alignment
Range on Protein: 319-570
Range on HMM: 23-277/439.0
EREFQLLNGAVPDELSDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVML
. .|. .| . ||   .   |.|  .  |||| .. . .  ||.|  ||    . |||| |..|| ..  .||||.| ..| .||||.|... .  ||||
keifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivml

CGLNEPLEVFFSAIYTYLCW-WGGGRWTLKKTNGVIVSEINFNP--KTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKHLDRPVVVHCSDG
. | |    . |   ..           ..  | ||     ||   .|   | . .| |. | .. ||..   ..|..  .. |  |.   ||||||| |
tnlvesykywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsag

VGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILA
|||||.  .|  .||..|||  .|.    ..|| ||  || .| || . |.|.| 
vGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle

0041856 (Phosphotyrosine protein) phosphatases II 344-571 1.2e-42 140.9 In-house 1-170 (182) alignment
Range on Protein: 344-571
Range on HMM: 1-170/182.0
NSKKNRYPNILPCERCRvvlpaipdkeDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCglneplevffS----Aiytylcww
| .||||..|||... |          | .||||... |..    |||||.||..|..||.||.... . .||.|.          .    .        
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..........eelywp........

gggrwtlkktngvivseinfnpkTGEVRQISHFMYLEWTEHAVPTkLLTIIDLIGDLQKarrkhLDRPVVVHCSDGVGRTGAFCTLFATLERvkleGvLD
                       . . |.. ...|| |  | ||. | ...|.| . ..      ..||.|||| ||||||... ..  ...    | ..
.......................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vs

VFITARMLRTQRPGMVSHLDQYRLCYEAILAY
.. . ...| .||||| ...||.... |.| .
leeavklvrsrRpgmvitpnqyfflqlallel

0049772 (Phosphotyrosine protein) phosphatases II 316-575 2.6e-42 141.0 In-house 19-283 (314) alignment
Range on Protein: 316-575
Range on HMM: 19-283/314.0
TGLEREFQLLNGAVPDELSdFYTATQPKNSKKNRYPNILPCErCRVVLPAIPDkEDTTYINASYLEGYqekVAFIATQAPLDNTIEDF----------WR
..|. ..  ... |. ||. ...| ...| .||||..||| . .||.||  |  ... ||||||. |.    .|||||.||..|..||          ||
lklllvlnrrslsvlpelt.ilvadlflnrdknryldilpad.nrvilpglpv.sgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwr

MV--WHEEVFCIVM---------------------LCGLNEPLevffsaiytylCWWGGGRWTLKKtngvivseI-NFNPkTGEVRQISHFMYLEWTEHA
||  .   |  |||                     |..| ..            ...   .. | |           ..|     |.. ..... .. . 
mvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng...........neptaadlellk........eelydp.elferlgikylripvpDgs

VPtKLLTIIDLIGDLQKArrkHLDRPVVVHCSDGVGRTG--AFCTLFATLERVKLEGVLDVFITARMlRTQRPGMVSHLDQYRLCYEAILAYLDSF
.|  |  . ...  ...|   . ..||.|||..|.||||  ... .   | .| || .|. .  .|.    .||..  |.||  ..||.| ||. .
ap.lledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefilealleylkfl

0049260 (Phosphotyrosine protein) phosphatases II 88-281 2.8e-42 139.3 In-house 1-144 (152) alignment
Range on Protein: 88-281
Range on HMM: 1-144/152.0
WIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWpeeneqygeiivtleekeeladfeirkfflrklsnqmetrmvkHF
.|||... ...|||.||  .|..|||||..|.. ...||||.|.|.||.||..|.                                           ..
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qy

YFTSWPDHDVPEYATGLLEFWKRVRNSwEGPQSGPITVHCSAGVGRTGTFIVIDAMMeqikeeNLLDVYSYVSRIRAQRNFMVQRPSQYSFIHY
... |||| ||. .  ||.. . ..      ..||. ||||||||||||..... |.      . .... .|...|..|. .|. |.|. |...
lhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye

subfamily_PTPN3_pd Subfamily PTPN3 321-571 6.9e-42 138.3 In-house 20-274 (280) alignment
Range on Protein: 321-571
Range on HMM: 20-274/280.0
EFQLLNGAVPDElsDFYTATQPKNSKKNRYPNILPCERCRVVLpaipDKEDTTYINASYLE----GYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIV
.|. |    |.   .  .| .|.| .|||| .||| .  || |    ....| ||||.|..    . .  . .|||| ||..| .|||.|||....  ||
qfeqlyrkkpgl..aisaarkpenlsknryrdilpydatrvkl....kesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssliv

MLCGLNEPLEVFFSAIY---TYLCWWGGGRWTL---KKTNGVIVSEINFNPK-TGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRkHLDRPVV
||  | |   |     .   .  . .|. . ..   ..|. ... |.  . | | | |.| .. ||.|..|.||..   .....  ..|.|.   ..|||
mlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrs.gkeePvv

VHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAY
|||| |.|||| . .|  .|  .  .  . .    |..| ||  .|   .||..  ||||. 
vhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv

subfamily_ptpA1_pd Subfamily ptpA1 14-247 8.1e-42 138.4 In-house 13-256 (418) alignment
Range on Protein: 14-247
Range on HMM: 13-256/418.0
LKQHYLRMHAnsdllFEKEYKDIKEPVNV-TTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQgDSESTDYINANWIDGFkQEKKYIATIGPKAETTSDF
||.|   .|       ..|.. ..| |    |   |.  |  |||| ||   .|.|| |  .| | | .||||||.|||    |..|.| ||  .| .||
lknhikcihk.....ikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiq.dkegsdyinanyidga.ypkqfictqgplpntiadf

WRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEE--NEQ----------YGEIIVTLEEKEELADFEIRKFFLRkLSNQMETRMVKHFYFTSWPDHDVPEY
|||.|| .  |.|||..  |. ..|| .||||.   ||          .|   | | |  .  . ||    .| |. . ||| . .. .  ||||..|..
wrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnir.ltfegetrditqyqyegwpdhnipdh

ATGLLEFWKRVRNSWEG--P---QSGPITVHCSAGVGRTGTFIVIDAMMEQI
.  . .. . . |  .   |   .  || |||||||||||||     ||...
tqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkl

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 50-285 5e-40 132.0 In-house 53-287 (305) alignment
Range on Protein: 50-285
Range on HMM: 53-287/305.0
LINKPKNRYGNIKAYDHSRVILSSVQgdseSTDYINANWIDG-FKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEE---
 |.. |||| .. . |.| | |.  .     .||| ||..   .  ||..|.. ||  .|  .|| |. ..|   .||| | || ||.|| .|||     
diaitknryqdvpcqdqsavkldkps....psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqge

-NEQYGEIIVT-L-EEKEELADFEIRKFFLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSwegpqSGPITVHCSAGVGRTGTFIVIDA
  |  . |.|  .   |    | ||.   |.   .  ..  |.|. .| |||  ||      ||.   .| |       || ||||||.||||| . |. 
klelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgs.....kvpivvhcsagigrtgtivaiey

MMEQIKEENLL-DVYSYVSRIRAQRNFMVQRPSQYSFIHYALLE
..|.| |..    .   |  .| || | .|   || |||  .|.
ilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln

0051429 (Phosphotyrosine protein) phosphatases II 372-579 7.7e-40 132.6 In-house 4-232 (272) alignment
Range on Protein: 372-579
Range on HMM: 4-232/272.0
TTYINASYLEGYqekVA------FIATQAPLDNTIEDFWRMvWHEEVFCIVMLCGLNEplevffSAIYTYLCWWGGGRWTLKKTNGVIVSEINFNP----
..||||... ||           ......||..|..||||. ... . .||.|....|       . . . . | | |.    ...  . .|...     
sgyiNardvggy...grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeE......rgrlkcdrywpgirylhlpilddsaptilygalrvt

---------------------KTGEVRQISHFMYLEWTEHAVPTK-LLTIIDLIGDlqkarrkhlDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLD
                     ..||.|.. |..|. |  | ||.. ||....|. |         ..||.|||| |..||| .. |.  |..| || ..|
llseellldyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld.........ggpvlvHCsaGkdRTGtvvallllllgvsletivd

--------VFITARMLRTQRPGMVSHLDQYRLCYEAILAYLDSFEESQ
        .. . ..|| ||||.| . .||. .|||.|..|.|. ...
dYlltnlyleeaveelraqrpgavqteeqylflyeallellrsllsvr

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 318-571 1.7e-39 130.4 In-house 8-258 (267) alignment
Range on Protein: 318-571
Range on HMM: 8-258/267.0
LEREFQLLNGaVPDELSDFYTATQPKNSKKNRYPNILPCERCRVVLPaipDKEDTtYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVM
.|.||.|..  . |. |   .    || ..||. . || .  ||.|    .||.  ||||||.|||. | |||.|| ||.||| ||. .. ...|  ||.
iekefelikk.isdtsstisqsiaeknqernrlddnlpyddtrvilr...tkeee.yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivl

LCGL-NEPLEVFFSAI------YTYLCWwgggRWTL-KKTNGVIVSEINFNPKTGEVRQISHFMYLEWTEHAVPTKLLtiIDLIGDLQKARRKHLDRPVV
|     . .  |.         |  |        .| |. |   .  .... |    .... . | .|   .     |    |.| | | . .  .||.|
ltkvftdnirlfwPPkmgqakkyqdltv....ehslekeendyqiitlelkfknesahnvtlyyykkwnintnnkpyl..kplfgilaknqlengnrPlv

VHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAY
|.|||||||.|.| .. . |||.| |||.|.|   | .| ||.|.|  ...|  ..| .  |
vacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey

0044763 (Phosphotyrosine protein) phosphatases II 64-285 2.6e-39 130.1 In-house 2-169 (178) alignment
Range on Protein: 64-285
Range on HMM: 2-169/178.0
YDHSRVILSSVQGdSESTDYINANWIDGFkqekKYIATIGPkaettSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEENEqygeiivtleekeela
.|..||.||...|  |..|||||..|...     |... .|     .|......|.. . .|.||. .| |..||..|||||..                
ldrtrvllsnleg.lersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

dfeirkfflrklsnqmetrmvKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEgPQSGPITVHCSAGVGRTGTFIVIDAMMEQikeeNLlDVYSYVSRIR
                      ..... .|||.||.    .||| . ...  . .. ||. |||||||||.||..... |...    .| .... ....|
.....................iqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvr

AQRNfMVQRPSQYSFIHYALLE
..|. .|..|.|. ....  |.
erRp.ivpnpgqlrqLyefelr

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 52-285 3.6e-39 129.3 In-house 48-285 (305) alignment
Range on Protein: 52-285
Range on HMM: 48-285/305.0
NKPKNRYGNIKAYDHSRVILssvqGDSESTDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEEN-----
.. |||| ..   |. || |      .   .|| ||..    . |..| |  |  .| .||| | ...|   . || .|.|||  ||..|.. ..     
eagknrykdvgcldnnrvkl....egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvle

--EQYGEIIVTLEEKEEL-----ADFEIRKFFLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRnswegPQSGPITVHCSAGVGRTGTFIV
  |.   |.| .|  ..|     |. ....  |       ..| |.|...  |||  ||   . .||. .. |     |  |||.||||||.||||. ..
feekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekar.....pskgpivvhcsagigrtgsvvm

IDAMMEQIKEENLLD-VYSYVSRIRAQRNFMVQRPSQYSFIHYALLE
.. ...|. . . ..     . .|| |||  .|   || |.|  .|.
leyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 40-287 4.4e-38 125.9 In-house 25-270 (285) alignment
Range on Protein: 40-287
Range on HMM: 25-270/285.0
VNVTTRHCDnlINKPKNRYGNIKAYDHSRVILSSvqgdsESTDYINANWIDG-FKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKC
 |.|    .   |   ||| .... . .||.|          ||| |.|.    |..  ||.| ||  || ||||.|... | . |.||  |.| |  ||
pnctytaye..anpdlnryadvrcieetrvvlkn.....hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekc

HKYWPEE---NEQYGEIIVTLEE-KEELADFEIRK-FFL-RKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSweGPQSGPITVHCSAGVG
  |.||.     ..|.  .|| | |||     | . . .        |   ..|     |||.  || |  ..|..| |..    |.  || ||||||||
alyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkv..npkekpicvhcsagvg

RTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAV
|| ||. ||    .| |.  ...   |  .|| |   ||   |. |..  |.| .
rtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 29-289 1.2e-37 124.6 In-house 21-273 (288) alignment
Range on Protein: 29-289
Range on HMM: 21-273/288.0
FEKEYKDikEPVNVTTRHCDNLINKP-KNRYGNIKAYDHSRVILSsvqgdSESTDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVML
 .|||.|   | . . .  |. |..| ..|| |.   | .|| ||      ..  ||.|| .   | ... | .  |   |   .|.|. |     .|||
lkkeyrd..spneasidiidsfianptrdryenlprcditrvkls.....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivml

TKLVEKGKVKCHKYWPEENEQYGEIIVT-LEEKEELADFE-IRKFFLRKLSNQMETRM-VKHFYFTSWPDHDVPEYATGLLEFWKRVRNSwegpqSGPIT
..|.|||| |  .|.| .  .   |       |.. || . . |  | . |...|... ||. ..  |.|. |||     | . .....        || 
cellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlksl.....qkPiv

VHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTF
||.|||||||||.|.|  ..|... .. | . | ... |..|   .|   || ..|  .|| . .
vhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelll

0051082 (Phosphotyrosine protein) phosphatases II 80-284 1.5e-37 123.9 In-house 2-150 (151) alignment
Range on Protein: 80-284
Range on HMM: 2-150/151.0
STDYINANWIDGFkqekkYIATIGPkaetTSDFWRMMWEHKSSIVVMLTKLVEKGkvKCHKYWPEENeqygeiivtleekeeladfeirkfflrklsnqm
 .||||.....|.     .... ||    ..||.....|.. . .|.|....| |  .|..|.||..                                 
lsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.................................

etRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNswegPQSGPITVHCSAGVGRTGTFIVIDAMMEQikeenlLDVYSYVSRIRAQRNFMVQRPSQYSFI
  . |.|.....|||...|..   .|||.. ...    ...||. ||||||.|||||..... |...      ..... .. .|..|  .|| . |. |.
..ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfq

HYALL
..|||
lfall

0043147 (Phosphotyrosine protein) phosphatases II 370-566 1.6e-37 124.2 In-house 3-155 (172) alignment
Range on Protein: 370-566
Range on HMM: 3-155/172.0
EDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLneplevffsaiytylcwwgggrwtlkktngvivseinFNPKTGEVRQI
|...|||||||..|     |||||.||.||..|||||.... . .||.|..|                                     ........|..
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.....................................lydpellerlg

SHFMYLEWTEHAVPtKLLTIIDLIGDLQKARRKHLDRPVVVHCSDGVGRTGAFCTLFATLervklEGVlDVFITARMLRTQRPGMVSHLDQYRLCYE
 ...|| |  | ||  |  .....  ....  .  . ||.|||| ||||||... ..  |     .|. ... . ...|..|||.| . .|||..|.
iqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.....lgl.sleeavalvrekRpgavqnpsqyrflyy

0036282 (Phosphotyrosine protein) phosphatases II 372-566 4.2e-37 122.9 In-house 2-164 (174) alignment
Range on Protein: 372-566
Range on HMM: 2-164/174.0
TTYINASYLEGYQEKVAFIATQAPLDntiedFWRMVWHEEVFCIVMLCGLNEPLeVFFSAIYT-YlcwwgggrwtlkktngvivseinfnPKTGEVRQIS
..|||||.| ..     .||.|.||.     ||.|.... . ..|||. ..|.   .    |.                            .. ..| . 
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelg.lykcinywpe.........................lredlerlgi

HFMYLEWTEHAVPTKLLtIIDLIGDLQKARRKHLDRPVVVHCSDGVGRTGAFCTLFATLERVKlEGVLDVFITARMLRTQRPGMVSHLDQYRLCYE
...|| |  | ||.    .....  ...|. .. ..||.|||| ||||||... ..  | . . |.. |.. . |.||.|||||| . .||| .|.
qylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 462-578 2e-35 117.4 In-house 170-286 (318) alignment
Range on Protein: 462-578
Range on HMM: 170-286/318.0
KTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKHLDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQY
.. |.||.  . | .|... ||..  ...||... .|| .|.  .|.||||| |||||| |... . |||.| |...||| | ..||.||. ||   |||
eeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqy

RLCYEAILAYLDSFEES
 ..|...| .| |..  
efiydvllealasgdte

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 41-279 1.7e-34 114.0 In-house 33-273 (301) alignment
Range on Protein: 41-279
Range on HMM: 33-273/301.0
NVTTRHCDN------LINKPKNRYGNIKAYDHSRViLSSVQGDseSTdYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKG
||||   |.       ..| |.|| ..    .. |    |.|       | ||||.   . ...||| ||  .|. ||| |.  ..   .|||.. ||| 
nvttidkdhitesyaylpkdkhryptvPckPstav.evivdGk..rv.PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekl

KVKCHKYWPEENEQ---YGEIIVTLEEKEELADFEI--RKFFLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSwegpqSGPITVHCSA
. ||..| | . ..    |   .....|| . . .|  |.. ..  .....|| | |. ...|.|..||.  . | .. . |..|       || |||||
eekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkks.....ekPivvhcsa

GVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFI
|.||. .||  . .  ... .. ...   . ..| .|   ||. ||  ..
GiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlywm

subfamily_PTPRG_pd Subfamily PTPRG 312-423 3.3e-34 113.0 In-house 15-127 (563) alignment
Range on Protein: 312-423
Range on HMM: 15-127/563.0
GTGMTGLEREFQ-LLNGAVPDElSDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDT-TYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWH
  | .|...||. | .  ....  |  .. .|.| .|||| ||.. .| || |  .|.|...  ||||.|..||| . |||||| || .|..|||||.| 
adgdigfseefealqsetiskd.ldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWe

EEVFCIVMLCGLNE
..|  |||.  |.|
qnvaiivmitnlve

PTPc_DSPc_SM00012 184-285 5.1e-34 112.0 In-house 2-105 (105) alignment
Range on Protein: 184-285
Range on HMM: 2-105/105.0
VKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGPQ-SGPITVHCSAGVGRTGTFIVIDAMMEQIKEE-NLLDVYSYVSRIRAQRNFMVQRPSQYSFIHY
|||...|.|||| |||... .||. . |... .  . |.|. |||||||||||||...| ...|...| . .|.. .|...| ||. |||.  ||.|.. 
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

ALLE
||||
alle

0046846 (Phosphotyrosine protein) phosphatases II 366-573 5.5e-34 112.8 In-house 6-174 (176) alignment
Range on Protein: 366-573
Range on HMM: 6-174/176.0
IPDKEDTTYINASYLEGYqekvAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEPLEVFFSAI--------Ytylcwwgggrwtlkktngvivsei
. . .| .||||... |.    ..||||.|| .|..||..|.... . ..|.|. . |   . .  .        .                        
lgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi........................

nfnpktgevrqisHFMYLEWTEHAVPTKlLTIIDLIGDLQKARRKHldRPVVVHCSDGVGRTGAFCTLFatleRVKLEGVLDVFITARMLRTQRP-GMVS
             ....| | .| ||.    ...|.  ...|....  .||.|||| |.||||... ..     ..||  |.|. . ...| ||| |.| 
.............qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavq

HLDQYRLCYEAILAYLD
. .||| .||..| .|.
tpeQyrflyefellllk

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 343-569 7.7e-34 111.9 In-house 6-237 (239) alignment
Range on Protein: 343-569
Range on HMM: 6-237/239.0
KNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQE-KVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEPLEVFFSAIYT-YLCWWG
 |  |||| ||.  .. ||||  . .   . |||||||  |.    |.||||  .  .  |||||.|.|    |||| || |  .      .      . 
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskyc

GGRWTLKKTNGV----IVSEINFNPKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKhLDRPVVVHCSDGVGRTGAFCTLFATLERVKLEG
  | ||.||. .    | . .  .    | | . .. .  | .. ||    ... |   . |       || |.||| ||||||||  . | | . | . 
nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslp.garpwvihcsagvgrtgaflvidamlrqakkqk

VLDVFITARMLRTQRPGMVSHLDQYRLCYEAIL
 .|.|   . .| .|| ||   .|| . . |.|
tvdifnyvkairedrphmvqtseqyvfihlavl

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 343-569 8.7e-34 111.7 In-house 7-238 (239) alignment
Range on Protein: 343-569
Range on HMM: 7-238/239.0
KNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQE-KVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEPLEVFFSAIYT-YLCWWG
 |  |||| ||.  .. ||||  . .   . |||||||  |.    |.||||  .  .  |||||.|.|    |||| || |  .      .      . 
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskyc

GGRWTLKKTNGV----IVSEINFNPKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKhLDRPVVVHCSDGVGRTGAFCTLFATLERVKLEG
  | ||.||. .    | . .  .    | | . .. .  | .. ||    ... |   . |       || |.||| ||||||||  . | | . | . 
nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslp.garpwvihcsagvgrtgaflvidamlrqakkqk

VLDVFITARMLRTQRPGMVSHLDQYRLCYEAIL
 .|.|   . .| .|| ||   .|| . . |.|
tvdifnyvkairedrphmvqtseqyvfihlavl

subfamily_PTPN9_pd Subfamily PTPN9 301-421 1.7e-32 107.7 In-house 1-119 (297) alignment
Range on Protein: 301-421
Range on HMM: 1-119/297.0
MRLMQLAEKVAGTGMTGLEREFQLLNGAVPDelSDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTI
.....| . |  .|  || .|.. .    .     |... .. |..|||| ..|  .. ||||. ....| . ||||....||..| |||||| ||..|.
keieelvayvkekgkrGlskeyaeirnepve..GtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktv

EDFWRMVWHEEVFCIVMLCGL
.||||||| .||. |||   .
sdfWrmvWeqevlvivmttrv

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 337-423 2e-32 107.6 In-house 39-125 (318) alignment
Range on Protein: 337-423
Range on HMM: 39-125/318.0
YTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNE
. ...| | .|||| |||. ...|| |  . ..|.. ||||.|..||..| |.||.|||| .||||||||||  .   ||||  ..|
lkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeee

subfamily_CG42327_pd Subfamily CG42327 52-214 5e-32 105.8 In-house 28-193 (319) alignment
Range on Protein: 52-214
Range on HMM: 28-193/319.0
NKPKNRYGNIKAYDHSRVILSSvQGDSESTDYINANWIDGFKQE-KKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEE-----
 |.|.|. |.    ..||.| . .|| ... |..|... |...    |||.  .  ...|||||..|| .| ..| ||.| |.|  .| .|.| .     
skdksrvinvvPlPetrvvlqr.igdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldn

NEQYGEIIVTLEEKEELADFEIRKFFLRKLSnQMETRMVKHFYFtSWPDHDVPEYATGLLEFWKRVRNS
.. ||.| ||| ..|    . |  . |...  . |.| . |...  |.. .||   . |.    .||.|
tslyGdilvtlkgrevkdryaistlllkrvd.keesrelthywy.kwleaevPaeeaaliamllevrss

subfamily_Ptp69D_pd Subfamily Ptp69D 316-423 5.9e-32 106.0 In-house 22-127 (307) alignment
Range on Protein: 316-423
Range on HMM: 22-127/307.0
TGLEREFQLLNGAvpDELSDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCI
 ||..|.. |.        .  .. .  |  ||||..| . .. ||.|. |. |||..|||||...||.||  ||| |.|...||.|||||..  ||  |
fglakeyekLear..eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtli

VMLCGLNE
|||  |.|
vmlsnlte

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 318-571 1.7e-31 103.9 In-house 13-268 (281) alignment
Range on Protein: 318-571
Range on HMM: 13-268/281.0
LEREFQLLNGAVPDELSDFYtaTQPKNSKKNRYPNILPCERCRVVLPA-IPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIV
...||  | |  | .|   .   || | ||||| ||   .  || |   .|.|. | || | |.     |  .| || |  .|  |||||.|.|.  .||
fkqefsnlpgdppsdlctvf..nqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaiv

MLCGLNEPL-----EVFFSAIYTYLCWWG-GGRWTLKKTNGVI-VSEINFNpKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLigdLQKARRKhlDRPVV
||| . |       | |    .  | .      .     |  .  . .|.    || | |.|... || .  ||     .. .   |.| | .    | |
mlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnls.yegetrlithwlwkewpdwqvpessevmlki...lrkirar..stppv

VHCSDGVGRTGAFCTLFATLERVKLEGVL-DV-FITARMLRTQRPGMVSHLDQYRLCYEAILAY
.||| ||||.|.. ..  .|. ..    | |.  | ...  | |   |  |.|| | .. .| .
ihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf

0049260 (Phosphotyrosine protein) phosphatases II 380-566 2.8e-31 103.7 In-house 2-144 (152) alignment
Range on Protein: 380-566
Range on HMM: 2-144/152.0
LEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEPLEVFFSAIYtylcwwgggrwtlkktngvivseinfnpktgevrqisHFMYLEWTE
..||  . .|||||.|..||..|||||...  . .||||. | |  ....   .                                     ....| |  
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.....................................qylhlpwpD

HAVPTKLLTIIDLIGDLQKArRKHLDRPVVVHCSDGVGRTGAFCTLFATLervkleGVLDVFITARMLRTQRPGMVSHLDQYRLCYE
| ||.    ...|.  ..|. ... . ||.|||| ||||||... ..  |        .... . ...|..|||.| . .|.|..||
hgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 54-207 5e-31 102.6 In-house 35-189 (297) alignment
Range on Protein: 54-207
Range on HMM: 35-189/297.0
PKNRYGNIKAYDHSRVILSSVQGDSestDYINANWIDgFKQE---KKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEE---NE
 |||| .| |.| .|| |  |  ..   |||||...  | .|    ||| . ||  .|  |||....|.   ..||..|| | |. ||  |||.    . 
rknryrdilatddtrvkllrviter...dyinadyvv.fpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerl

QYGEIIVTLEEKEeLADFEIRKFFLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEF
. |...|    .    .|.  ..   .|  . |.|.|.|  | ||||| ||     |  |
kagdvvveflsst.sdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrf

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 175-323 7.9e-30 98.5 In-house 82-230 (440) alignment
Range on Protein: 175-323
Range on HMM: 82-230/440.0
LSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPS
  | .|.| .|.... .|||. ||..|  .|.. . | .| |   .||. ||||||.||||  |..|... . |  . .|..|... .| .|  ||| | 
yingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpe

QYSFIHYALLEAVTFGDTEIEVQNLRMRLMQLAEKVAGTGMTGLEREFQ
||.|.| |.||..  ||| |  ...  |. |.      |  . |..||.
qyafvheavlegllcgdtliledditerveqiqwpnphtdksplqqefe

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 53-294 5.6e-29 95.7 In-house 53-296 (310) alignment
Range on Protein: 53-294
Range on HMM: 53-296/310.0
KPKNRYGNIKAYDHSRVILSSvqGDSESTDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEE--NEQYG
  |||| ..   | ||| |      |   ||| ||..      . .| . ||   |  |||||... ..  ...| | .|.|. ||  |||     | ||
mhknrysdvvcldtsrvklki..dksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetyg

EIIVTlEEKEELADFEIRKFFLR---------KLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEfwKRVRNSwegPQSGPITVHCSAGVGRTGTFIVID
 | || .  |   .||| .. .          .   ...   |.   .  |||  ||.     .   .|.       . ||  ||||||..|... . ..
cirvt.nlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp..qrllaq...vrhgpcvvhcsagkdrlyvvvalk

AMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLeAVTFGDTEI
  ...... . .|.   .. .. .|   .| . || .|..  . . . |.||.
lkidkldrglkvdaeevktellksraiciqtelqyliidrvri.ifargetev

0051082 (Phosphotyrosine protein) phosphatases II 371-568 9.1e-29 95.4 In-house 2-149 (151) alignment
Range on Protein: 371-568
Range on HMM: 2-149/151.0
DTTYINASYLEGYqekvaFIATQAPLDntieDFWRMVWHEEVFCIVMLCGLNEPLevffsAIYTYLCWWGggrwtlkktngvivseinfnpktgevRQIS
 ..|||.||..|.     ......||.    ||....... . .||.|... |.        . ||  .|                          ... 
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg.....ycpeylpelg..........................ievl

HFMYLEWTEHAVPTKLLTIIDLIGDLQKarrkHLDRPVVVHCSDGVGRTGAFCTLFATLERvklegvLDVFITARMLRTQRPGMVSHLDQYRLCYEAI
|. .| |... .|. . ......  |..    . . ||.|||| |.||||... |.  |..      .... . ...| .|||.| . .|..... |.
hipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfal

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 342-573 1.2e-28 94.6 In-house 52-284 (290) alignment
Range on Protein: 342-573
Range on HMM: 52-284/290.0
PKNS--KKNRYPNILPCERCRVVLpaiPDKEDTTYINASYLEGYqeKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEPL----EVFFSAIYTY
 ||.  ||||| ..   .. ||.|    |  |  |. | |..|   |  || || .| .|. |.|||| .|.|  ||||| | |      | ..      
dkntefkknrykdvvcndktrvil...kdGydGdyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGe

LCWWggGRWTL------KKTNGVIVSEIN-FNPKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKArrkhlDRPVVVHCSDGVGRTGAFCTLFAT
   .  | .|.      .| . .|   .   . ..|   .. |.    | ...|.   |... ..  |.||       ||||||| |.||||.| .. ..
vltf..GeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka.....sGpvvvhcsaGiGrtGtfvaievg

LERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYLD
|. .     ||.  . | ||  | . |    || .  |..| .  
lqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGk

subfamily_PTPRK_pd Subfamily PTPRK 336-424 3.4e-28 93.4 In-house 35-123 (314) alignment
Range on Protein: 336-424
Range on HMM: 35-123/314.0
FYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEP
. .| . .| .|||. .||. .|.||.| .| .  .. ||||.....|.   |||.|| ||..|..||||.|..|.  .||||  | | 
wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvev

PTPc_DSPc_SM00012 469-569 5.1e-28 92.7 In-house 2-104 (105) alignment
Range on Protein: 469-569
Range on HMM: 2-104/105.0
ISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKHL-DRPVVVHCSDGVGRTGAFCTLFATLERVKLE-GVLDVFITARMLRTQRPGMVSHLDQYRLCYE
..|. |..|..| ||..   |..|. ...| ..|.    |||||||.|||||| |..|   |.... | . .|.| . ..||.||||||. ..||  .|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AIL
|.|
all

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 30-286 9.8e-28 91.7 In-house 22-275 (312) alignment
Range on Protein: 30-286
Range on HMM: 22-275/312.0
EKEYKDIKEPVnvTTRHCDN-LINKPKNRYGNIKAYDHSRVILSsvqGDSEstDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLT
 |||| . . |  .   |   |  |  ||| ||. .|  |  |.   || .   || ||..    . .....| ||  .|.. ||..     |. ...|.
tkeykavgniv..sdsectaflkfkdlnrypniqcwdrgrftla...gden..fyihanfvkictkperfvctqgplentcthfwqlalslgstsiillc

KLVEKGKVKCHKYWP--------EENEQYGEIIVTLEEKEELADfEIRKFFLRKL-SNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNswegpQ
 .|| |  || ||          |.   | |    .|      |  | .  |. .     .   ..|. ..||||| .|.     | .   |..     .
gfvedgsekcakyisdivgfvdledhrvyteycteieiggkskd.kithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkk.....d

SGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEA
  |.  |||||||||||...|..|.  ..     .|      .| .|   |.   || .   ..|| 
kkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlef

subfamily_PTPRK_pd Subfamily PTPRK 463-570 1.2e-27 91.6 In-house 169-275 (314) alignment
Range on Protein: 463-570
Range on HMM: 169-275/314.0
TGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKhLDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYR
  |.|.. .| .| |..| ||..  ....|.  ..| . .  . ..||||| | ||||.|...   |. .. |||.||| ... ||.... ||   .||.
qeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqyk

LCYEAILA
..|..|| 
fiydvile

subfamily_PTPRD_pd Subfamily PTPRD 506-577 2.3e-27 90.9 In-house 215-286 (564) alignment
Range on Protein: 506-577
Range on HMM: 215-286/564.0
RPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYLDSFEE
 |.||||| ||||||.|... | |||.| |...|.. . ..||.||. ||   .||  ..|||| .|.....
gPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnt

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 309-572 3.4e-27 90.2 In-house 12-271 (288) alignment
Range on Protein: 309-572
Range on HMM: 12-271/288.0
KVAGTGMTGLEREFQLLNGAVPDELSDFYTAtqpkNSKKNRYPNILPCERCRVVLPaipDKEDtTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVW
.|   .. ||..|..      . .  | . |    |. ..|| |.  |. .|| |    |  |  ||.|  .   . |  .| .||||. ||| .|.|. 
lvlqiaveglkkeyrdspneasidiidsfia....nptrdryenlprcditrvkls...ddpd.fyiaanvvssakykrrlicaqaPlngtieelWkmll

HEEVFCIVMLCGLNE----PLEVFFSAIYTYLCWWGGGRWTLKKT----NGVIVSEINFNPKTGEVRQ-ISHFMYLEWTEHAVPTKLLTIIDLIGDLqka
...|  ||||| | |      ...|          |      ||     . ...  .  . |.|| .. . .  .||| ...|| . |. . |.  |   
esdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl...

rrKHLDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYL
  | |..|.|||.| ||||||..   .  || ..|.  | .      || .|   .    ||   .  .| .|
..kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleel

0048076 (Phosphotyrosine protein) phosphatases II 151-284 3.5e-27 90.2 In-house 15-140 (145) alignment
Range on Protein: 151-284
Range on HMM: 15-140/145.0
EIIvTLEEKEELADFEIRKFFLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGPqsGPITVHCSAGVGRTGTFIVIDAMMEqikeE
 .  | .. |.|.|. |.  .      . ..|.. ......||||.||. .  |||| . ...  . .  ||. ||||||||||||..... |..    .
slp.taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmll....l

NlLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALL
. ..... . ..|.|| ..|..|.|. |.....|
g.vsleealelvrsqrpgavpnpgqlrflyefel

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 342-423 3.7e-27 90.0 In-house 18-100 (270) alignment
Range on Protein: 342-423
Range on HMM: 18-100/270.0
PKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQE-KVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNE
 ...| ||| .|||  . ||.|. . ... |.|||| |..|... | ..||...||..|...||||.|.|.| .|||. ||.|
argkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleE

subfamily_PTPN6_pd Subfamily PTPN6 293-422 7e-27 89.2 In-house 3-133 (306) alignment
Range on Protein: 293-422
Range on HMM: 3-133/306.0
EIEVQNLRMRLMQLAEKVAGTGMTGLEREFQLLNGAVPDELSDFYTATQPKNSKKNRYPNILPCERCRVVLPaIPDKEDTTYINASYLEGYQ--EKVAFI
..  .... |  .| ..   .. .|.| ||. |.     .| .   ...|.| .|||| |||| .  ||.|   |.  ...||||.|... .  .. ..|
sllakeieqrvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyi

ATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLN
|||  |..|..||||||| |.   |||.   .
atqgclettvsdFWrmvwqensrvivmttkev

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 102-302 8.1e-27 88.9 In-house 39-235 (255) alignment
Range on Protein: 102-302
Range on HMM: 39-235/255.0
IgpkaeTTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEENEQ---YGEIIVTLEEkeELADFEIRKFF-LRKLSNQMETRMVKHFYFTSWPDHDV
.     |   |....   |.. ||||. . |.|..||..|.| | ..   . .. ||  .    ||  .|    . .|... .|. |||. .. |...  
l.....tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWiekna

PEYATGLLEFWKRVRNSwEgpqsgPITVHCSAGVGRTGTFIVIDAM----MEQIKE--ENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVtFGD
|| |  .|. .| ||.|       .. ||||.|.||. .|.... .    . ....     ||  | .  .| .|.  .. | | .|  . .|. | |  
Pelareilnilkvvrds.k.....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv.fpk

TEIEVQNLRMR
.|.| .  ..|
geleakyqeir

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 450-573 1.9e-26 87.4 In-house 172-294 (301) alignment
Range on Protein: 450-573
Range on HMM: 172-294/301.0
NGVIVSEINFNPKTgEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKHLDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRT
|| | .... . .  . ...  .   .| .. |     |..  | |  ....|    ||||||||.|.|.| .|..  .|| .| ||| |||   . .| 
ngyierkfkvksdk.sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrr

QRPGMVSHLDQYRLCYEAILAYLD
..||.|  |.||   |..|  || 
skpgaVtTLeqytsiydvidmylq

0048179 (Phosphotyrosine protein) phosphatases II 175-281 3.2e-26 87.2 In-house 40-139 (144) alignment
Range on Protein: 175-281
Range on HMM: 40-139/144.0
LSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEgpQSGPITVHCSAGVGRTGTFIVIDAMMeqikEENlLDVYSYVSRIRAQRNFMVQRPS
  .. ..|.. ......||||.||.... |||| . ...  |  ..||. ||||||||||||..... |.    ... |.... . ..|..| ..|. |.
yepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpg

QYSFIHY
|. |...
qlrfLle

subfamily_PTPN13_pd Subfamily PTPN13 448-574 4.3e-26 86.8 In-house 146-271 (273) alignment
Range on Protein: 448-574
Range on HMM: 146-271/273.0
KTNGVIVSEINFN-PKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRkhLDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARM
| .|  |.... .  ..||.|...|. . .| .| ||.. . .. ..  ... ..     |.||||| |.||.|.. |. . |. .. .  .||  . | 
kldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrk

LRTQRPGMVSHLDQYRLCYEAILAYLDS
|| || |.|   ||| ..|.|||  | |
lreqrqgvvqtkdqyifvykailevlks

subfamily_Ptp69D_pd Subfamily Ptp69D 460-573 7.7e-26 85.9 In-house 175-287 (307) alignment
Range on Protein: 460-573
Range on HMM: 175-287/307.0
NPKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKHlDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLD
 ..  . |..  . |..| .  ||    ....||  ...  ...   |.||||| ||||.| | .|   |...|.|  .|.| | . || ||. .|  |.
sgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsle

QYRLCYEAILAYLD
||  .| |.| | .
qYvflyralldyss

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 380-567 1.5e-25 84.5 In-house 229-433 (440) alignment
Range on Protein: 380-567
Range on HMM: 229-433/440.0
LEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEPLEVFFSAIYTYLCWWGG---GRWTLKKTNGVIVS--EINFNPKTGEVRQISHFMY
.|||  | |||||| ||| |. ||||.|   ..  |.||  ||.     .  . |    .|    |    .. | | |   |.... .  |.||.    .
fegyskknafiatqmpldstvldfwrlvhdyristiimlnqlndktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkykeevheirqfevqtw

LEWTEH-AVPTK---LLTIIDLIGDLQKA---RRKH-----LDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYR
  | .   | ..   . ....|.  |.|    |           |..|||  |.  .| |||..  ||... .| .|||   |.||  || .|  | .| 
ptwiqsdgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvptltdyl

LCYEA
|||  
lcykl

subfamily_CG7180_pd Subfamily CG7180 445-571 3e-25 83.5 In-house 158-289 (296) alignment
Range on Protein: 445-571
Range on HMM: 158-289/296.0
TLKKTNGVIVSEINFNPKTGEVRQISHFMYLEWTE-HAVPTKLLTIIDLIGDLQKARRKH----LDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLD
|.| |  ..    . .. . |.| . .| . ||   . ||    ..|.|.   .. |.|        ||||..|||..|.|..... |.|| |. |. .|
tfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevd

VFITARMLRTQRPGMVSHLDQYRLCYEAILAY
||  ...|| .||..|   ..|. .|. .| .
vFeavktlrrsRpqLvenveeYkyiYdvllea

0044763 (Phosphotyrosine protein) phosphatases II 355-568 4e-25 83.9 In-house 1-167 (178) alignment
Range on Protein: 355-568
Range on HMM: 1-167/178.0
PCERCRVVLPAIPDKEDTTYINASYLEGYqekvaFIATQAPLdntiEDFWRMVWHEEVFCIVMLCGLNEPLevfFSAIY-------Tylcwwgggrwtlk
|..|.||.|. ... | . |||||.  ..     ......|     .|...... . . .||.|..  |.    |   .                     
pldrtrvllsnleglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelg...flkcdpywpeeag.............

ktngvivseinfnpktgevrqiSHFMYLEWTEHAVPTKLLTIIDLIGDLQKAR-RKHldRPVVVHCSDGVGRTGAFCTLFATLERvkleGVlDVFITARM
                       ..... .  | ||. |  . ...  ...|. .|.  .||.|||| ||||.|... ..  ...    |. ...   ..
......................iqylhipipDhgvpdllehflefvefieealdekg..gpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaiel

LRTQRPgMVSHLDQYRLCYEAI
.| .|| .| . .|.| .||  
vrerRp.ivpnpgqlrqLyefe

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 306-419 4.1e-25 83.5 In-house 5-116 (281) alignment
Range on Protein: 306-419
Range on HMM: 5-116/281.0
LAEKVAGTGMTGLEREFQLLNGAVPDELSDfyTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWR
 ...      .|. .|.. |. .  |. .    .....| .|||| ||   .  ||..    ....| ||||....||... ..||||.|. .....||.
hlkqlsqndnaGfieeyeklaaigvdntat..askadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWq

MVWHEEVFCIVMLC
||| ..|  |||. 
mvweqkvsaivmvt

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 447-573 5e-25 83.0 In-house 133-265 (270) alignment
Range on Protein: 447-573
Range on HMM: 133-265/270.0
KKTNGVIVSEINFNpKTGEVRQISHFMYLEWTEHAVPTKLL------TIIDLIGDLQKARRKHLDR-PVVVHCSDGVGRTGAFCTLFATLERVKLEGVLD
.|..| |. ... . ..|| |.. ||.| .| .|.||..         .. .. .... .... .  |..||||.|||||| . .|  ... .. .. .|
ekeegyiltrlrle.ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvd

VFITARMLRTQRPGMVSHLDQYRLCYEAILAYLD
|    . || .|. .|.| .||.. |.|.. | .
vlaiieelRkdRmalvqhpeqyeflykavveyae

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 345-551 5.7e-25 82.7 In-house 51-260 (301) alignment
Range on Protein: 345-551
Range on HMM: 51-260/301.0
SKKNRYPNIlPCERCRVVlPAIPDkEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEPLEVFFSaiyTYLCWW-----
 .|.|||.. ||.    |   | |      | | ...   .   |||||.||.|| |||| |. . .|  ||||.   | ||   .   .||  .     
kdkhryptv.PckPstav.evivd.GkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekce...eylpvkisekl

GGGRWTLKKTNGVIVS-------EINFNPKTGE--VRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKArrkhlDRPVVVHCSDGVGRTGAFCTLFATLE
  ||...| .|   .        ... .  ||.   | . |. | |||.. ||     . ||.  ..|.     ..|.|||||.|.||. || .      
digrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkks.....ekPivvhcsaGiGrsvafigteylar

RVKLEGVLDVFITARMLRTQR
.|. .  ...  . . || .|
eveadptieltealkhlrehr

subfamily_PTPN6_pd Subfamily PTPN6 462-574 7.5e-25 82.5 In-house 181-299 (306) alignment
Range on Protein: 462-574
Range on HMM: 181-299/306.0
KTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKHL---DRPVVVHCSDGVGRTGAFCTLFATLERVK---LEGVLDVFITARMLRTQRPGMV
| .| |.. .. . .| .|.||..  ...|.. |... ...      .|.|||||.|.||||.|  . . |. ..   |.  .|.  . ...|.|| |.|
kkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglv

SHLDQYRLCYEAILAYLDS
   .||.. |.|| .|...
qteqqykfvykaikkyiet

subfamily_PTPN9_pd Subfamily PTPN9 460-572 9.2e-25 82.3 In-house 166-290 (297) alignment
Range on Protein: 460-572
Range on HMM: 166-290/297.0
NPKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKA-----------RRKH-LDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARML
| ||.| |...|| .| | .. ||    ...|..   ...            . |  . |.||||| |.||||.|.||  .|.|.. .|..||. | ..|
nvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkll

RTQRPGMVSHLDQYRLCYEAILAYL
||||  ..   .|| .|| |.| | 
rtqrafsiqtpeqyefcylavleya

subfamily_CG7180_pd Subfamily CG7180 339-420 9.8e-25 81.8 In-house 37-118 (296) alignment
Range on Protein: 339-420
Range on HMM: 37-118/296.0
ATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCG
. . .| .|||.....| .  ||||. .  .|.. ||||.| ...  | ..| |.|| ..|...|||.|. ||. ..|.|. 
glrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtk

subfamily_ptpA1_pd Subfamily ptpA1 318-420 4.5e-24 79.9 In-house 23-122 (418) alignment
Range on Protein: 318-420
Range on HMM: 23-122/418.0
LEREFQLLNGAV-PDELSDfytATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKvAFIATQAPLDNTIEDFWRMVWHEEVFCIV
.. ||.||. .| | | |.     . .|. |||| |||| .. || |  | ||| . |||| |..|   |  ||.|| || ||| ||||||| . .  ||
ikeefrlleesvgpsetse...gdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk.qfictqgplpntiadfwrmvwenrcriiv

MLCG
||  
mlsr

subfamily_egg_pd Subfamily egg 41-285 4.7e-24 79.6 In-house 31-271 (307) alignment
Range on Protein: 41-285
Range on HMM: 31-271/307.0
NVTTRHCDNLINkpKNRYGNIKAYDHSRVILSSVQGDSeSTDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKgkVKCHK
..||   ||  .  | |   ..  | ||| |   .|   . |.| || ..|     ..| .  |  .|  |||||... .   .||||  .|    .|. 
slttaasdnnle..karskrvhckdssrvklelrrGqy.lddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..ercey

YWPEENEQ---Y--GEIIVTLEEKEELADFEIRKFFLRKLSNQMETRMVKHFYFTSWPDHDVpeyaTGLLEFWKRVRNswegpQSGPITVHCSAGVGRTG
|||  ...   .  | . ..  . .. ||   |   |. .  . | | ..|.        ||       |.  ...||      | |. |..  || ...
ywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqgdvnnssdv....ysplrvlrklrn.....lskpvvvqdilGvskaa

TFIVID-AMMEQIKEEN-LLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALL---E
|.. |. |... ..       |   |  .| .|.. |. . .| |..  .|    
tlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffr

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 93-280 8.8e-24 78.8 In-house 2-197 (199) alignment
Range on Protein: 93-280
Range on HMM: 2-197/199.0
KQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEEN---EQYGEIIVTLEEKEELADFEIRKFFLRK-LSNQMETRMVKHFY
| ...||||  |  || .|||.|.||  |  .||.     . ..    |||  .    .|| . || .     .|. |  . | .  .    || . |. 
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

FTSWPDHDVPEYA--TGLLEFWKRVRNSWEGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEE--NLLDVYSYVSRIRAQRNFMVQRPSQYSFIH
|||| ..  |. |   |..   . | . .|  .  |. |||| | | || |. .|  .   .|    ..|..    |.|  |  ..    .| ||.
ftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 88-280 1e-23 78.3 In-house 82-281 (302) alignment
Range on Protein: 88-280
Range on HMM: 82-281/302.0
WIDGFKQEKKYI-ATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEENE---QYGEI-IVTLEEKEELADFEIRKFF-LRK--LSN--
 .|| .. .|     | || .|.  .| .. ... .||| |...||... || .|. .. .   ..|.  . |.. |..|..|  .| | | .  . |  
pmdGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknek

--QMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVrNSWEgpqsGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQ
  .   . |. ..|..||||  |. |   |.  |   .|.       . ||||||||||||.. |   ..  ....  |. | |  .|. |   ||  .|
kkkkvkktvdilafsawpdhGapkeaytaldilkfc.esyk....knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqq

YSFIH
  .. 
liyll

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 94-280 1.2e-23 78.4 In-house 2-196 (198) alignment
Range on Protein: 94-280
Range on HMM: 2-196/198.0
QEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEEN---EQYGEIIVTLEEKEELADFEIRKFFLRK-LSNQMETRMVKHFYF
 ...||||  |  || .|||.|.||  |  .||.     . ..    |||  .    .|| . || .     .|. |  . | .  .    || . |. |
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TSWPDHDVPEYA--TGLLEFWKRVRNSWEGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEE--NLLDVYSYVSRIRAQRNFMVQRPSQYSFIH
||| ..  |. |   |..   . | . .|  .  |. |||| | | || |. .|  .   .|    ..|..    |.|  |  ..    .| ||.
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 451-574 2.2e-23 77.8 In-house 154-278 (281) alignment
Range on Protein: 451-574
Range on HMM: 154-278/281.0
GVIVSEINFNPKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKHLDRPVVVHCSDGVGRTGAFCTLFATLERVKLE-GVLDVFITARMLRT
  |  ... . ..|| |..... |. | .| ||..   ...   ...|...|. . |.|.||| ||||||.. .|   ...|. |   |||  . . || 
tyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrk

QRPGMVSHLDQYRLCYEAILAYLDS
.|  ||  . ||.  | |.| .|| 
ernlmvqtvvqyefvykavldaldk

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 54-160 3.3e-23 77.0 In-house 49-166 (350) alignment
Range on Protein: 54-160
Range on HMM: 49-166/350.0
PKNRYGNIKAYDHSRVILS-------SVQGDSESTDYINANWIDGF----KQEK--KYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHK
 |||| ||  |.||||.|        ...   .. ||||||..       ...   ||||| .|  .|  ||.... . |  ....||..|| .  ||..
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPEENeqYGEIIVTLEEKE
||.| .  | .| | |..| 
YWqegs..ydditvklaskw

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 333-418 1.4e-22 74.8 In-house 27-111 (287) alignment
Range on Protein: 333-418
Range on HMM: 27-111/287.0
LSDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKeDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVML
   | .|..  . ||||| ..|| .  ||.| | ...  . |||| |. .|... ||||.|.|.  |. ||||.|.....  ....
tatfkaaeelaavkknryadvlPiddtrvllsaegel.GsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitm

subfamily_PTPRG_pd Subfamily PTPRG 464-577 2.3e-22 73.9 In-house 180-292 (563) alignment
Range on Protein: 464-577
Range on HMM: 180-292/563.0
GEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKHlDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRL
 ..... .. | .| .|.||.. |  .  .   ..|....   |.||||| |||||| .. | . |.... | . .|| .....|.||. .|   .||  
dteklvrqyhytkWPdhgvPehslpvLifvkkssaankae.aGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYif

CYEAILAYLDSFEE
 ..|.|  . | |.
lhdalleaiasket

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 338-423 7.4e-22 72.4 In-house 34-121 (301) alignment
Range on Protein: 338-423
Range on HMM: 34-121/301.0
TATQPKNSKKNRYPNILPCERCRVVLPAIPD--KEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNE
  .. .|.. ||. || . .  |..|   |.  .  ..||||||..||.|| .|||.|.|...|. ||||..|.| .  |||...|.|
vglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlke

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 60-309 9.1e-22 72.5 In-house 26-265 (290) alignment
Range on Protein: 60-309
Range on HMM: 26-265/290.0
NIKAYDHSRVILSsVQGDSESTDYINANWIDgFKQEKKYIATIGPKAET-------TSDFWRMMWEHKSSIVVMLTKLVEKGKV----KCHKYWPEENE-
..    ..||.|  . |   . ||| || .  . .  . |.|  |....         .|| |. . |.  |||| .  || .      | || ||. . 
evpLveatrvvLk.gygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvge

--QYGEIIVTLEEKEELADFEIRKFFLRkLSNQmETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSwegpqSGPITVHCSAGVGRTGTFIVIDAMME
  ... . |   .||.  |.|.|.  ..   .. |   |.|  . .| .  |.|    ||.  . |..|       |. |||  |. |  ..  |.  . 
elkfkgltvkCkskekeddvetRelvvk.fdde.eeftvtHsllkgWnklnvqedtktllsliqkvkas.....ktpvivHcvdGiSrsAalaaiilgyQ

QIK-EENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLeavtfgdteievqnlrMRLMQLAEK
 |   .. . . . .. .| ||. ..... ...|. ....                .....  ..
kiaetsgsvkledvlkalrkqralaitsalelafvdagiv................llaievldq

subfamily_hpo-7_pd Subfamily hpo-7 107-299 9.5e-22 72.1 In-house 45-243 (263) alignment
Range on Protein: 107-299
Range on HMM: 45-243/263.0
ETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEENE---QYGEIIVTLEEKEElaDFEIR-KFFLRKLSNQMETRMVKHFYFTSWPDHDVPEYAT
.|   |....   |.. ||||.   |.|..|| .|.| | .   .. .. |.  .  .  |  .. . .|  |... .|. |||. .. |...  || | 
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpelar

GLLEFWKRVRNSwEgpqsgPITVHCSAGVGRTGTFIVIDA----MMEQIKEE--NLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFG--DTEI
  |.  | .|||       .. ||||.|.||.  | |..     |. ....     ||  | .  .| .|.  .. | | .|  . .|. |       |.
eilnilkvarns.k.....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfakgel

E--VQNL
|   |..
eakyqei

subfamily_PTPN14_pd Subfamily PTPN14 334-422 2.3e-21 71.1 In-house 39-128 (300) alignment
Range on Protein: 334-422
Range on HMM: 39-128/300.0
SDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKeDTTYINASYLEG--YQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLN
....||. |.| .|||....|| | .|| | .  .. .| ||||| ..     ..  .|..|.||..|..|||.||| ..|  ||||   .
allstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteee

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 387-566 6.7e-21 69.4 In-house 5-198 (199) alignment
Range on Protein: 387-566
Range on HMM: 5-198/199.0
VAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEPLEV----FFSAIYTYLCWWGGGRWTL----KKTNGVIVSEINFNPKT--GEVRQISHFMYLE
  .|||| || .|. |||.|||      |||.   .   |.    ....  .    .|    |      | . .|.. |  |  |     |.|||. .  
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WTEHAVPTKLLTIIDLI--GDLQKARRKHLDRPVVVHCSDGVGRTGAFCTLFATL---ERVKlEGVLDVFITARMLRTQRPGMVSHLDQYRLCYE
| |.. |   | .  ..   .. |   .  | ||.|||||| | || | .|   .   |  |   |.|.|  |. ||  | |..| |..| . |.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 388-566 7.7e-21 69.2 In-house 5-197 (198) alignment
Range on Protein: 388-566
Range on HMM: 5-197/198.0
AFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEPLEV----FFSAIYTYLCWWGGGRWTL----KKTNGVIVSEINFNPKT--GEVRQISHFMYLEW
 .|||| || .|. |||.|||      |||.   .   |.    ....  .    .|    |      | . .|.. |  |  |     |.|||. .  |
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

TEHAVPTKLLTIIDLI--GDLQKARRKHLDRPVVVHCSDGVGRTGAFCTLFATL---ERVKlEGVLDVFITARMLRTQRPGMVSHLDQYRLCYE
 |.. |   | .  ..   .. |   .  | ||.|||||| | || | .|   .   |  |   |.|.|  |. ||  | |..| |..| . |.
kekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_CG42327_pd Subfamily CG42327 342-495 2.9e-20 67.2 In-house 26-189 (319) alignment
Range on Protein: 342-495
Range on HMM: 26-189/319.0
PKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQE-KVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEPL-EVF---F--SAIYT
.   .|.|. |..|    ||||. |.|.. . |..|||. ||.. .  .||.|..|...  ||||.||      || |. | |   .|    .  ..   
vtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketld

YLCWWGGGRWTLKKTNG---VIVSEINF-NPKTGEVRQISHFMYlEWTEHAVPTKLLTIIDLIGD
    .|  . |||. .     ..| . . . .  | |...|. | .| |  ||..  ..| .. .
ntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamlle

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 337-571 3.1e-20 67.3 In-house 29-269 (285) alignment
Range on Protein: 337-571
Range on HMM: 29-269/285.0
YTATQpKNSKKNRYPNILPCERCRVVLpaipDKEDTTYINASYLEG-YQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEP----LEVFFSA
||| .  |   ||| ..   |  ||||     . |  || ||..    ... ..|.|| || .|. |||.|...|..  ..||| | |       ...  
ytaye.anpdlnryadvrcieetrvvl....knhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyype

IYTYLCWWGGGRWTLKKTN-----GVIVS---EINFNPKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKhlDRPVVVHCSDGVGRTGAFC
    .  .|    || . .     | |.     || .  . |   . |     | ..  |     .|.|   ..|   |  ..|..|||| ||||| .| 
klgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk..ekpicvhcsagvgrtatfv

TLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAY
 .  .  |.  .  ....   | .|. |   |    |. . |  .. |
gidyatirimenpniemldivremramrfqavqshmqflflyvvlmey

0048076 (Phosphotyrosine protein) phosphatases II 459-571 5e-20 67.1 In-house 37-142 (145) alignment
Range on Protein: 459-571
Range on HMM: 37-142/145.0
FNPKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKHldRPVVVHCSDGVGRTGAFCTLFATLErvklEGvLDVFITARMLRTQRPGMVSHL
 . .....|.. ...|| |  | ||. | ......  ...|....  .||.|||| ||||||... ..  |.    .| .... . ...|.||||.| . 
tselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqrpgavpnp

DQYRLCYEAILAY
.|.| .||..| .
gqlrflyefelel

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 49-286 5.7e-20 66.1 In-house 44-278 (303) alignment
Range on Protein: 49-286
Range on HMM: 44-278/303.0
NLINKPKNRYGNIKAYDHSRVILSsvqgDSestDYINANWIDgFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEENEq
 . |  |||. ..   |||.| ||    ||    || |.... .. .|| | |  | . |..|||.|. | |   |..|    |  |.  .  .|.... 
fvknmdknrfvdvicldhskvkls....ds...syihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqd.

YGEIIVTLEEKEELADFEIRKFFLR---KLSNQMETRMVKHFYFTSWPDHDVPEYA--TGLLEFWKRVRNSWEGPQSGPITVHCSAGVGRTGTFIVID-A
. ..        |.   |. . .      .||     ...  .. .||  ..|  .    . . |.         .| |      .|.||.||| ... |
flkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfeta

MMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEA
 .   .|.. ||.   .  .|  |   ||  ||.|...  | | 
hlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaeh

subfamily_PTPRN_pd Subfamily PTPRN 460-569 5.7e-20 66.2 In-house 180-289 (297) alignment
Range on Protein: 460-569
Range on HMM: 180-289/297.0
NPKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKhLDRPVVVHCSDGVGRTGAFCTLFATLERVKlEGV--LDVFITARMLRTQRPGMVSH
| .| | | .. | .| |.|..||..  .....   ..|. |     |.|||||||.||||... .   |.|..  ||  .|.  |   || ||||.|  
nlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG.rscpivvhcsdGaGrtGvyilidlvlnrll.kGvkeidiaatlehlrdqrpglvkt

LDQYRLCYEAIL
 ||..... |. 
kdqfefaltava

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 328-574 8.4e-20 65.7 In-house 27-278 (312) alignment
Range on Protein: 328-574
Range on HMM: 27-278/312.0
AVPDELSDFYTATQPKNSKKNRYPNILPCERCRVVLPAipdkEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEPL--
|| . .||   ..  |    ||||||   .| |  |      ..  || | ..        |..||.||.||.  ||...      .|..|||. |    
avgnivsdsectaflkfkdlnrypniqcwdrgrftlag....denfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgse

--EVFFS-----------AIYTYLCW--WGGGRWTLKKTNGVIVSEINfnpKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARrkhldRPVVV
    . |            .||  |     ||.   | |  |.   ..    ||.  .. |. .  | .| .|    |   |.  ..| .     .||. 
kcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvk...atgqesklnhyqwaswpdhgmpdscdtalrllsavkkdk.....kpvia

HCSDGVGRTGAFC---TLFATLERVKLEGVLDVFItarMLRTQRPGMVSHLDQYRLCYEAILAYLDS
||| ||||||...   .. |.|   . . | |.|.   .|| .|   |  . ||  .  ..| .| |
hcsagvgrtgtlaliesmiaalrhprkqnvkdsfv...llrkdrarsvrvfpqyvyalrcvleflys

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 28-284 1.7e-19 64.4 In-house 27-282 (302) alignment
Range on Protein: 28-284
Range on HMM: 27-282/302.0
LFEKEYKDIKEPvNVTTRHCDNLI-NKPKNRYGNIKAYDHSRVILSsvqgdSESTDYINANWIDGFKQEKKYIATIGPKAETT---SDFWRMMWEHKSSI
  .||.| |..   | . .|     |  ||.  .....|. .|.|.      |  .|.||  ..  . ... | .  || ...    .||||....|   
evkkefkkidtm.kvdlekCkafkknlkknqsedvpildsnlvkle.....aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivs

VVMLTKLVEKGKvKCHKYWP---EENEQYGEIIVTLEEKEELADFEiRKFFLRKLSNQM-ETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVrNSWEGPQ
||.| .  |  |   ....|   .. ..||.. |     |.  . .  .. .  | . . .. ...   .| |... ||.  . | .  . |    . . 
vvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv.fakkika

SGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALL
. .. .    |.|| |.|..  . .|......   .   |  ||.||  .|.  .|| ... |||
dentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiall

subfamily_PTPN14_pd Subfamily PTPN14 462-573 1.7e-19 65.0 In-house 178-297 (300) alignment
Range on Protein: 462-573
Range on HMM: 178-297/300.0
KTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKHL--------DRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPG
 ..| |.. |. | .|..| ||  . . .. . ..|  |||          . ||.||||.||||||   .    .. .. . ..|.  . ..||.||  
pskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrml

MVSHLDQYRLCYEAILAYLD
.|. | ||.  |.... ||.
lvqtlaqYkfvYkvlikylk

0048179 (Phosphotyrosine protein) phosphatases II 454-566 3.5e-19 64.4 In-house 34-139 (144) alignment
Range on Protein: 454-566
Range on HMM: 34-139/144.0
VSEINFNPKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKHldRPVVVHCSDGVGRTGAFCTLFatleRVKLEGvLDVFITARMLRTQRPG
.. ..  ... . |.. ....| |  | ||. |  .....  ...|....  .||.|||| ||||||......    ..|..| |... . ...|..|||
inlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg..gpvlVHCsaGvgRtgtlvaay....lmkklg.lsleealalvrsrrpg

MVSHLDQYRLCYE
.| . .|.| ..|
avpnpgqlrfLle

subfamily_PTPRN_pd Subfamily PTPRN 318-423 3.8e-19 63.5 In-house 31-136 (297) alignment
Range on Protein: 318-423
Range on HMM: 31-136/297.0
LEREFQLLNGAVPDElSDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQ-EKVAFIATQAPLDNTIEDFWRMVWHEEVFCIV
||.|.. |     .. |   .| ..|| ||||. ..|| .  || | .  ..|.. ||||| .   .  . |.||||.|| .|. |||.|||.. |  ||
lekewealcayeaep.stkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvviv

MLCGLNE
.|. |.|
nltrlee

subfamily_PTPN13_pd Subfamily PTPN13 338-419 8.2e-19 62.9 In-house 31-109 (273) alignment
Range on Protein: 338-419
Range on HMM: 31-109/273.0
TATQPKNSKKNRYPNILPCERCRVVLpaipdKEDTTYINASYLEG--YQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLC
.. . .| .|||| |.||... || |     .....|||||...    ...  .||.| || .|..|||.|||  ..  |.|. 
vgkkkenkdknryrnvlPydetrvkl.....gdeggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvt

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 224-290 1.3e-18 61.1 In-house 2-68 (69) alignment
Range on Protein: 224-290
Range on HMM: 2-68/69.0
TVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFG
 ||||.| ||||||| |   | .|| | |.|..  |  .|  |  ||    .| ||| || ||. .|
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 225-290 1.8e-18 60.6 In-house 2-67 (69) alignment
Range on Protein: 225-290
Range on HMM: 2-67/69.0
VHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFG
||||.| ||||||| |   | .|| | |.|..  |  .|  |  ||    .| ||| || ||. .|
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG

subfamily_PTPN1_pd Subfamily PTPN1 328-421 4.3e-18 60.0 In-house 14-105 (290) alignment
Range on Protein: 328-421
Range on HMM: 14-105/290.0
AVPDELSDFY--TATQPKNSKKNRYPNILPCERCRVVLpaipDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGL
 . .| |||   .| .|.| ..||| .. | . .|..|    ...|. ||||| .|  . |  .| || || ||.. ||.|||...  ..|||  .
dirkeasdfptreaklpenrnlnryrdvspydhsrikl....eradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkv

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 343-424 4.8e-18 60.2 In-house 2-82 (237) alignment
Range on Protein: 343-424
Range on HMM: 2-82/237.0
KNSKKNRYPNILPCERCRVVLPAIPDKedTTYINASYLEGYQEK-VAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEP
.|  |||| ||   . .||||     .  . ||||.||.|..     .||.| ||... .|||.||| |    |||| || | 
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltglieg

subfamily_egg_pd Subfamily egg 315-424 8.4e-18 59.1 In-house 13-120 (307) alignment
Range on Protein: 315-424
Range on HMM: 13-120/307.0
MTGLEREFQLLNGAVPDElsDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFC
. .||| ...|. .| ..   . || .  | .| | . .   . .|| |     .    .| | ...|      || .|||| || .||||||. |||  
vqelerrlevleesvdei..slttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqy

IVMLCGLNEP
||||    |.
ivmltsrkes

subfamily_eak_pd Subfamily eak 51-202 1.7e-17 57.8 In-house 51-199 (332) alignment
Range on Protein: 51-202
Range on HMM: 51-199/332.0
INKPKNRYGnIKAYDHSRVILSSVQGDseSTDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKCHKYWPEEN---E
 .  .| .. |  ||.  | |.| | .     ||||  ..  .  .||| |  .. .    ||.|. | ||  .|.| . ||..  |  ||.|..     
eavnrnvvk.ivpydrylvrltssqln..rlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreel

QYGEIIVTLEEKEELADFEIRKFFLRKlsnQMETRMVKHFYFTSWPDHDVPEYAT
..| . |.  |  . . .| |.. |.|     ||  |.|. .  | . ..| |  
kfGildverkefvkrniletrllelsk...GnethrvlhykvfGwtettlpkyed

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 343-571 2.7e-17 57.9 In-house 18-258 (290) alignment
Range on Protein: 343-571
Range on HMM: 18-258/290.0
KNSKKNRYPNILpCERCRVVLPAIPDKEDTTYINASYLEgYQEKVAFIATQAPLDN-------TIEDFWRMVWHEEVFCIVMLCGLNEPLEVFFS-AIYT
|.....|... |  |  ||||     .    || |...  . . ...|.||.|. .       |||.|| |.  |.|  .||||  .|. .   . |   
khemdqRlevpL.veatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCak

YLCWWGGGRWTLK----------KTNGVIVSEINFNPKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKArrkhlDRPVVVHCSDGVGRTGAFCT
|     |.  ..|          | ..|.. |.  .   .|  .. | .. .|..  |. . .|...||  ...      . ||.||| ||. |  |. .
YvpesvgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkas.....ktpvivHcvdGiSrsAalaa

LFATLERVK-LEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAY
.      .  ..| . .     .|| ||  ....  ..     .|. .
iilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivll

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 343-423 3.2e-17 57.3 In-house 46-140 (350) alignment
Range on Protein: 343-423
Range on HMM: 46-140/350.0
KNSKKNRYPNILPCERCRVVLPAIPD--------KEDTTYINASYLEGY----QEKVAF--IATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNE
.   |||| |||| |. || |.  .          .   ||||.||.      . .  |  ||||||| .|..||.... . .|  |..|  . |
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdve

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 7-102 7.4e-17 55.3 In-house 3-94 (95) alignment
Range on Protein: 7-102
Range on HMM: 3-94/95.0
QPIPVAELKQHYLRMHANSDLLFEKEYKDIKEPVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQgDSestDYINANWIDGFKQEKKYIATI
.|| |. .. | | ||.|||  |..|.| |      .        | ||||. ||  || .||.|.. . ||   ||||| ..||. . . |||. 
kpihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttkr.ds...dyinacfvdgyarkncyiaaq

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 54-158 8.1e-17 55.6 In-house 50-167 (349) alignment
Range on Protein: 54-158
Range on HMM: 50-167/349.0
PKNRYGNIKAYDHSRVILSS------VQGDSES-------TDYINANWID--GFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKGKVKC
 |||| .|  |.||||.|        |   |.|        ||||||..    .. |||||||  |   |  ||....   .  .|. |..  |..  ||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

HKYWPEENeqYGEIIVTLEE
..|| | .  | .| | | .
diywqels..ysnitvklqn

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 312-423 1.2e-16 55.6 In-house 12-118 (307) alignment
Range on Protein: 312-423
Range on HMM: 12-118/307.0
GTGMTGLEREFQLLNGAVPDELSdfyTATQPKNSKKNRYPNILPCERCRVVLPAipDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEE
  |.. |  ||. |    |. ..   . .   |..|||| ..   ...|.|.    |   . || | ||    .   ||..| ||.||. .|| |.  |.
dkgvqalvdefrvlakktpegvt...veafsantdknryqdvkcqdkgrivvkf..dglasdyihanylgiaikpkkficaqgplentqysfwamaiqek

VFCIVMLCGLNE
| ...||| . |
vesvimlckvie

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 335-423 1.5e-16 55.2 In-house 24-112 (297) alignment
Range on Protein: 335-423
Range on HMM: 24-112/297.0
DFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDttYINASYLEGYQE--KVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNE
.| .| ..   .|||| .||  .  || |   . ..|  |||| |.   .|  .. .| .| ||..|..|||..|....|  |||.. |.|
sfssakrnsslrknryrdilatddtrvkllrviterd..yinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqe

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 463-573 2.8e-16 54.2 In-house 164-278 (287) alignment
Range on Protein: 463-573
Range on HMM: 164-278/287.0
TGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDL----QKARRKHLDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHL
| | | .  . .|.| .....   . .| .. |     . ||      |.|||.. |.||.| . .... ..| .  | .||  .   || .| ..|   
trearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqav

DQYRLCYEAILAYLD
 |.|| |||. .|  
vqlrllyealvtyyk

subfamily_PTPN1_pd Subfamily PTPN1 460-570 3.7e-16 53.7 In-house 155-269 (290) alignment
Range on Protein: 460-570
Range on HMM: 155-269/290.0
NPKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARRKHLD-RPVVVHCSDGVGRTGAFCTLFATLERVKLEGV---LDVFITARMLRTQRPGMV
| || | |.|.|| |. |.. .||    . .... .....     |  |.|.||| |.||.|.|| . . | ... ..    .|.  .   || .| |..
nlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGli

SHLDQYRLCYEAILA
   || |. | ||| 
qtadqlrfsylaile

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 314-421 7.6e-15 49.3 In-house 25-128 (310) alignment
Range on Protein: 314-421
Range on HMM: 25-128/310.0
GMTGLEREFQLLNGAVpDeLSDFYTATQpKNSKKNRYPNILPCERCRVVLpAIPDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVF
|. || .... |.    |  |  | | . |. .|||| ...  . .|| |  |       || | |.     . .|| .| ||. || |||||.. |   
gieglvkqyrkldakq.d.ssltyeayk.kymhknrysdvvcldtsrvkl.kidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqerae

CIVMLCGL
 |..||  
silllckv

subfamily_CG42327_pd Subfamily CG42327 219-283 1.1e-14 48.9 In-house 246-311 (319) alignment
Range on Protein: 219-283
Range on HMM: 246-311/319.0
QSGPITVHCSAGVGRTGTFIVIDAMMEQIKEE-NLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYAL
. ||..|||| ||||||. |  |  .....|  . .|.   || .| .|   |.   || ||.  |
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvl

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 302-423 8.9e-14 45.9 In-house 8-124 (305) alignment
Range on Protein: 302-423
Range on HMM: 8-124/305.0
RLMQLAEKVAGTGMTGLEREFQLLNGAvpDELSDFYTATQPKNSKKNRYPNILPCERCRVVLPAIPDKEdttYINASYLEGYQEKVAFIATQAPLDNTIE
..... ...   | .||  ||. ..    ...  . .  . ....|||| ..   .. || | .   .|   || | |.    .   || |||||..|  
qilkfvkrtlekgpaglraefvamkrf..ndfekmkafkeaqeagknrykdvgcldnnrvklegpwphe...yihanyvstptnpkrfictqaplektca

DFWRMVWHEEVFCIVMLCGLNE
||| | . . |  | ||| | |
dfwymclqdkveaifmlcnlle

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 217-286 1.3e-13 45.5 In-house 225-294 (297) alignment
Range on Protein: 217-286
Range on HMM: 225-294/297.0
GPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEA
 |.. .. |||||||||.|  .  |....... . . || . .| .| ||  .||   |. ... | |. 
mprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkk

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 309-422 1.7e-13 44.9 In-house 17-131 (305) alignment
Range on Protein: 309-422
Range on HMM: 17-131/305.0
KVAGTGMTGLEREFQLL-NGAVPDELSDFYTATQPKN--SKKNRYPNIlPCERCRVVLPAIPDkeDTTYINASYLEGY-QEKVAFIATQAPLDNTIEDFW
.    |.  |  ||. | . . ||     . | |  .    |||| .. ||.   .|. . |    . || | |.      .  ||..| |||.||..||
raldvgvdklreefrglakytrpdmtqvafnanqsadiaitknryqdv.pcqdqsavkldkps..psdyihanyvgcpmipekrficaqgpldqtidefw

RMVWHEEVFCIVMLCGLN
 || .. |  |||||   
wmviqnkveqivmlcktv

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 184-284 4.7e-13 43.6 In-house 217-341 (350) alignment
Range on Protein: 184-284
Range on HMM: 217-341/350.0
VKHFYFTSWPDH---DVPEYATGLLEF------WKRVRNSWEGPQSGPITVHCSAGVGRTGTFIVIDAMME------QIKE-EN-------LLDV-YSYV
| ....  |.|      ||     ||           ..  .  .| || ||||||||||||.. .| ...      ....  .       . |.    |
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

SRIRAQRNFMVQRPSQYSFIHYALL
 ..| ||  |||   |. ||. |||
nelrkqrismvqnldqfifiYeall

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 463-569 1.9e-12 41.9 In-house 129-236 (237) alignment
Range on Protein: 463-569
Range on HMM: 129-236/237.0
TGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKA-RRKHLDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQY
  ||| |  . .  | .. || .  ... .  .. .  .      | ..||| |||||| |  . | | . | . |.|..     .  .|| ..   |||
lkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqy

RLCYEAIL
 . ...||
vfihqtil

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 50-137 3e-12 40.6 In-house 32-117 (332) alignment
Range on Protein: 50-137
Range on HMM: 32-117/332.0
LINKPKNRYGNIKAYDHSRVILSSVQGDsesTDYINANWIDGFKQEKKYIATIGPKAETT-SDFWRMMWEHKSSIVVMLTKLVEKGKVK
| |   ||   . ..||||| |.  .|     |. ||.|.||. ..  || .  |  . |   ||||. |.| |.....  . || | |
lnnmdmnriphlycfdhsrvelapqdgk...ddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 469-572 3e-12 40.9 In-house 217-344 (350) alignment
Range on Protein: 469-572
Range on HMM: 217-344/350.0
ISHFMYLEWTEH---AVPTKLLTIID----LIGDLQKARRKHL--DRPVVVHCSDGVGRTGAFCTLFATLE-----------RVKLEG---VLD-VFITA
. .. .  | .      | ..|....    || ||      .     |..|||| |||||| ..||   |.            .||.    . | ..|. 
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

RMLRTQRPGMVSHLDQYRLCYEAILAYL
  || ||  ||  |||.  .|||.| | 
nelrkqrismvqnldqfifiYeallfyf

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 505-572 3.6e-12 40.7 In-house 228-295 (297) alignment
Range on Protein: 505-572
Range on HMM: 228-295/297.0
DRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYL
. ...|||| ||||.|      . |.... . . ||    ..|| ||. .|  |.|. |.|.|.|. |
nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 463-577 1.3e-11 39.1 In-house 172-282 (307) alignment
Range on Protein: 463-577
Range on HMM: 172-282/307.0
TGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKArrkhlDRPVVVHCSDGVGRTGAFCTLFATLER-VKLEGVLDVFITARMLRTQRPGMVSHLDQY
... | |.|. . .| .. ||   || |.|.   .         ||||||| ||||.|.  ..    .. .. .   |.    . ||.||.  .    ||
aqksrtiqhlqwenwpdrgvpqinltainlleavryd.....tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqy

RLCYEAILAYLDSFEE
   .  .| |.     
lylhrvlleyflelyk

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 335-424 1.4e-11 38.5 In-house 87-174 (244) alignment
Range on Protein: 335-424
Range on HMM: 87-174/244.0
DFYTATQPKNSKKNRYPNILPCERCRVVLPAipDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEP
 .  | .|.|| |||    || .  || |         ||||||..        .| || || .|  |||.|.    |  .|.|  ..| 
vmkdafnpnnswknregaglpfdfnrvplsk..gsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 509-569 2.9e-11 37.6 In-house 2-62 (69) alignment
Range on Protein: 509-569
Range on HMM: 2-62/69.0
VVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAIL
||||| | ||||.| ...  . |.| | ..|.|   . .|  || ||    .| . ..|. 
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalv

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 509-569 3.7e-11 37.2 In-house 1-61 (69) alignment
Range on Protein: 509-569
Range on HMM: 1-61/69.0
VVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAIL
||||| | ||||.| ..   . |.| | ..|.|   . .|  || ||   ..| . ..|. 
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalv

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 456-572 4.1e-11 37.2 In-house 175-287 (305) alignment
Range on Protein: 456-572
Range on HMM: 175-287/305.0
EINFNPKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLigdLQKARRkhLDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVL-DVFITARMLRTQRPGM
..  .   ...|...|. . .| .  ||.  |.|..|   |.|||   .  |.||||| |.||||.   |   |...    .. |     . .| ||   
vlviegpgekarkvthyhwidwpdrgvpaadlailel...lekarp..skgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnns

VSHLDQYRLCYEAILAYL
.   .|| . .. || |.
iqtdaqylfvhqvilnyf

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 391-549 4.2e-11 37.4 In-house 39-178 (255) alignment
Range on Protein: 391-549
Range on HMM: 39-178/255.0
AtqapldnTIEDFWRMVWHEEVFCIVMLCGLNEPLE----VFFSA-IYTYLCWWGGGRWTLKKTNGVIVSEINFNPKTG---EVRQISHFMYLEWTEHAV
        |.. |....   .   .|||| ..|        .|       | .      | | .. |..  ..   . |   . ... |..|  | |.  
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWiekna

PTKLLTIIDLIgdlqKARRKHldRPVVVHCSDGVGRTGAFCtlfatlervklegvLDVFITARMLRT
|     |  ..    |. |.   ..|||||| |.||. ||               |  ..  .|.|.
Pelareilnil....kvvrds..ksvvvhCstGiGrsaafv..............laelvyqkmirs

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 476-572 6.5e-11 36.2 In-house 190-285 (302) alignment
Range on Protein: 476-572
Range on HMM: 190-285/302.0
EWTEHAVPTKLLTIIDLIGDLqKARRKHLDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAYL
 | .. ||.|  ..|  . ..  |.  . | ..|.    |.|| ||| ||....|... .    .  ... .|.||| .|  |.||   | |.| |.
nWkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 70-194 6.6e-11 36.6 In-house 11-123 (130) alignment
Range on Protein: 70-194
Range on HMM: 11-123/130.0
IlssvqgdseSTDYINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKgkvkcHKYWPEEN--EQY-GEIIVTLEEKEELADfe
            .||||...    . ..|. |  | |.|. |||.|| |    ..|.|  . |.      .|||. .  | |  .||||| ...|     
q.........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdrdefkn..

IRKFFLRKLSNQME-TRMVKHFYFTSWPD
|.  .|.  |. .|  . .  |  . || 
ikasnleiesdlneshqaltmfqisnwps

subfamily_PTEN_pd Subfamily PTEN 181-281 1.3e-10 36.5 In-house 79-174 (184) alignment
Range on Protein: 181-281
Range on HMM: 79-174/184.0
TRMVKHFYFTswpDHDVPEYATgLLEFWKRVRNSWEGPQSGPITVHCSAGVGRTGTFIVIdAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIH
. .|... |.   ||  |.    | |. . ...  |  ..  . ||| || ||||. ||   .... . |.  .. .. ...|.. .  |. |||  ...
dgrvavypfd...Dhnppplel.leeivediekwleedkknvvvvHCkaGkGRtGvliva.yllkslllekaeealelfaeaRtknkkgvtiPsqrRYve

Y
|
Y

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 343-419 1.8e-10 34.7 In-house 47-139 (349) alignment
Range on Protein: 343-419
Range on HMM: 47-139/349.0
KNSKKNRYPNILPCERCRVVLPAIPDKED--------------TTYINASYLEGYQE--KVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLC
.   |||| .||| |  ||.|.  .                    |||| ||.  .   .  .|||||||  |..||....  ..|  .. | 
elfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLn

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 502-572 1.8e-10 34.7 In-house 258-344 (349) alignment
Range on Protein: 502-572
Range on HMM: 258-344/349.0
KHLD----RPVVVHCSDGVGRTGAFCTLFATLE----------RVKLEGVL--DVFITARMLRTQRPGMVSHLDQYRLCYEAILAYL
..||     ...|||| | |||| ..||   |.          ..||. .|   ..|.   || ||  ||  | |.  .|||.| |.
lyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 7-93 2.6e-10 34.2 In-house 4-87 (440) alignment
Range on Protein: 7-93
Range on HMM: 4-87/440.0
QPIPVAELKQhYLRMHANSDlLFEKEYKDIKEPVNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDSeSTDYINANWIDGFK
.|| ||.. . |..    |   || |.  .   .   .  .    || |||| || |||||||.|  |.|   ..||||| .|.| .
rpiivadfad.yvqnnrrsr.afedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvp.dsdyinasyingie

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 321-419 3.1e-10 34.2 In-house 27-115 (303) alignment
Range on Protein: 321-419
Range on HMM: 27-115/303.0
EFQLLNGAVPDELSDFytaTQPKNSKKNRYPNILPCERCRVVLpaipdkEDTTYINASYLEGYQEKVAfIATQAPLDNTIEDFWRMVWHEEVFCIVMLC
||. . . .| ..|        || .|||. ...  .  .| |       |..|| |||||   .| | | || ||  |  |||.|. .. | |...| 
efekvvsylppsvskn...qfvknmdknrfvdvicldhskvkl......sdssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvllll

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 340-418 6.1e-10 33.1 In-house 33-116 (347) alignment
Range on Protein: 340-418
Range on HMM: 33-116/347.0
TQPKNSKKNRYPNILPCERCRVVLPAI-----PDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVML
   |. .|||  .    .  ||||        .  .  ||||||..   . .  .| || || .|. |||.||    |  .| .
ewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 38-127 1.2e-09 32.1 In-house 25-116 (347) alignment
Range on Protein: 38-127
Range on HMM: 25-116/347.0
EPVNVTTRHCDNLINkpKNRYGNIKAYDHSRVILSSVQGDSESTD----YINANWIDGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVML
 | ..|.   .. ..  |||  . |  | .||.||  . .   .|    ||||  |   . .|.|| |  |  .|  |||.|.   | . || .
spskftsveweksls..knrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti

subfamily_ptpA1_pd Subfamily ptpA1 463-529 1.6e-09 32.0 In-house 182-253 (418) alignment
Range on Protein: 463-529
Range on HMM: 182-253/418.0
TGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKAR---RKHLDR--PVVVHCSDGVGRTGAFCTLFATL
 || |.|... |  | .| .| .   . .|.  . . .       ||  |..|||| ||||||.|||    .
egetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimm

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 212-285 1.8e-09 31.4 In-house 257-342 (349) alignment
Range on Protein: 212-285
Range on HMM: 257-342/349.0
RNSWEGPQSGPITVHCSAGVGRTGTFIVIDAMME----QIKEENLLDVYS--------YVSRIRAQRNFMVQRPSQYSFIHYALLE
|. ..  |. .. |||||| ||||... .| ...      .| | ... .         |  .| ||  |||  .|. .|. |||.
rlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLk

0038934 (Phosphotyrosine protein) phosphatases II 186-276 2.1e-09 32.8 In-house 81-166 (194) alignment
Range on Protein: 186-276
Range on HMM: 81-166/194.0
HFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGPQSGPITVHCSAGVGRTGTFIVIdAMMEQIKEeNLLDVYSYVSRIRaqrNFMVQRPSQY
...   .||. ..     ||.| . |    .  ..| . ||| ||.|||||...  ....  .  .. . . .....|   . ........
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa.YLiyrlgm.saeeAialfrekR...pgaipnqdyl

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 454-572 2.5e-09 31.2 In-house 175-289 (305) alignment
Range on Protein: 454-572
Range on HMM: 175-289/305.0
VSEINFNPKTGEVRQISHFMYLEWTEHAVPTKLLTIIDLIGDLQKARrkhldRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVL-DVFITARMLRTQRP
.. .|..   ..   . |. . || .  ||   || ..|.  .. ..      |.||||| |.||||.  ..   ||..  .     .    . || || 
itllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk.....vpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqra

GMVSHLDQYRLCYEAILAYL
  .    ||   .  .| |.
fsiqndvqylfihrvmlnyf

subfamily_hpo-7_pd Subfamily hpo-7 391-524 3.8e-09 30.8 In-house 42-173 (263) alignment
Range on Protein: 391-524
Range on HMM: 42-173/263.0
AtqapLDNTIEDFWRMVWHEEVFCIVMLCGLNEP----------LEVFFSAIYT--YLCWWGGGRWTLKKTNgVIVSEINFnpkTGEVRQISHFMYLEWT
     | .||. |....   .   .||||  ||           ||     ...   .|       .|.||. ...| ..      ..... |..|  | 
l....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktl.ellstlge...KkkthtvkhysykgWi

EHAVPTKLLTIIDLIgdlqKARRKHldRPVVVHCSDGVGRTGAFCT
|.  |..   |. ..    |. |.   ...||||| |.||. ||  
ekndpelareilnil....kvarns..kslvvhcstGiGrsaafsv

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 344-420 5.2e-09 30.0 In-house 34-109 (332) alignment
Range on Protein: 344-420
Range on HMM: 34-109/332.0
NSKKNRYPNILPCERCRVVLPAIPDKEDttYINASYLEGYQEKVAFIATQAPLDNTIE-DFWRMVWHEEVFCIVMLCG
|   || | .   .. || |     |.|  . |||...|| .| |.| .|||...  |  |||||   .   |...  
nmdmnriphlycfdhsrvelapqdgkdd..fynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgd

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 338-393 5.5e-09 30.1 In-house 41-94 (95) alignment
Range on Protein: 338-393
Range on HMM: 41-94/95.0
TA-TQPKNSKKNRYPNILPCERCRVVLPAipdKEDTTYINASYLEGYQEKVAFIATQ
|. .   |  |||. ||.| .  |||| .   | |. |||| ...||  | ..||.|
tvgsseanipknrflnifpydatrvvltt...krdsdyinacfvdgyarkncyiaaq

subfamily_CG42327_pd Subfamily CG42327 503-571 5.6e-09 30.1 In-house 245-314 (319) alignment
Range on Protein: 503-571
Range on HMM: 245-314/319.0
HLDRPVVVHCSDGVGRTGAFCTLFATLERVKLE-GVLDVFITARMLRTQRPGMVSHLDQYRLCYEAILAY
.   |.||||||||||||   .   ......     .|.  .   .| .|   |   .|| . |  .  |
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey

subfamily_eak_pd Subfamily eak 217-305 1e-08 29.0 In-house 234-321 (332) alignment
Range on Protein: 217-305
Range on HMM: 234-321/332.0
GPQSGPItVHCSAGVGRTGTFIVIDAMMEQI--KEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTeiEVQNLRMRLMQ
 |   || . .. |  |.|.|.||| ... |  | .||  |  .. ... .|.  |    |.|||. ..|. .   .   ....|.  |. 
ppsfapi.iqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnn..rlrdlkkylea

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 97-193 2.4e-08 27.9 In-house 138-231 (244) alignment
Range on Protein: 97-193
Range on HMM: 138-231/244.0
KYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKgkvkcHKYWPEE--NEQYGE-IIVTLEEKEELADFEIRKFFLRKLSNQMEtRMVKHFYFTSWP
.|| |  | |.|. |||.|| | .  ..|.|  . |.      .|||.    | | | | ||| ...|. .    .. .    |.   . .  |  . ||
eyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdseplewyeeditvtltdrdefknikasnleiesdmnesh.qaltmfqisnwp





subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 33-148 3.9e-08 26.4 In-house 5-90 (169) alignment
Range on Protein: 33-148
Range on HMM: 5-90/169.0
YKDIKEP---VNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDSEStDYINAnwidgfkqekkyiatigpkaettsdfwRMMWEHKSSIVVMLTK
|...||    ..     ..  .|. |||     |  | || |  |  |  | |||||                           ||.||  .|..|.|  
ynelkefmktieynnfmaeltcnetknrpagplapshtrvklqrvmedlgs.dyina...........................rmiwetnasvivvlgd

LVEKgkvkcHKYWPEENEQ
  .|       .||| .. 
tddk.....nnfwpekedy

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 40-147 7.5e-08 25.4 In-house 14-88 (169) alignment
Range on Protein: 40-147
Range on HMM: 14-88/169.0
VNVTTRHCDNLINKPKNRYGNIKAYDHSRVILSSVQGDSEStDYINAnwidgfkqekkyiatigpkaettsdfwRMMWEHKSSIVVMLTKLVEKgkvkcH
..     ..  .|. |||     |  | || |  |  |  | |||||                           ||.||  .|..|.|    .|      
ieynnfmaeltcnetknrpagplapshtrvklqrvmedlgs.dyina...........................rmiwetnasvivvlGdtddk.....n

KYWPEENE
 .||| ..
nfwpeked

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 137-280 1.2e-07 25.5 In-house 149-295 (332) alignment
Range on Protein: 137-280
Range on HMM: 149-295/332.0
KCHKYWPEENEQYGEIIVTLEEKEELADFEIRKFFLRKLSNQMETRMV-KHFYftSWPDH-DVPEYATGLLEFWK--RVRNSW-EGPQSGPITVHCSAGV
 |.|.|||.. .     ....  .. ..  .. | |    .. . . |  |||   | |   .|||   .    |   .|.|   |   ||| . |..||
icrkfwpekrskkdfpalsiqasddhsethmktfnltvtekkqdhqtvlmhfy..ewadasklpeymldmrasiklqyirsskktgvcigpimlvcatgv

GRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIH
 .   .  || .. .| ||  . .   .| |. ||   ..    ||   
ekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpystac

subfamily_VSP_pd Subfamily VSP 193-282 1.2e-07 25.8 In-house 102-194 (212) alignment
Range on Protein: 193-282
Range on HMM: 102-194/212.0
PDHDVPEYAtGLLEFWKRVRNSWEGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKE--ENLLDVYSY--VSRIRAQRNFMVQRPSQYSFIHYA
 ||.||.    || | |.|..  |  ..  ...||  | ||||| .    .. .| |  .. || ..     . ....   || |||. ...| 
ddhnvpkle.ellvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgyl

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 90-162 2.5e-07 24.4 In-house 230-301 (440) alignment
Range on Protein: 90-162
Range on HMM: 230-301/440.0
DGFKQEKKYIATIGPKAETTSDFWRMMWEHKSSIVVMLTKLVEKgkvKCHKYWPEENE--QYGEIIVTLEEKEEL
.|. . . .|||  |   |  ||||.. ... | ..|| .| .|    |  ||| .     .| . |     |..
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpftvghkgsenm

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 343-428 3e-07 24.2 In-house 50-137 (302) alignment
Range on Protein: 343-428
Range on HMM: 50-137/302.0
KNSKKNRYPNILPCERCRVVLPAIPDKedttYINASYLEGYQEKVAFIATQAPLDNTI---EDFWRMVWHEEVFCIVMLCGLNEP---LEVF
||.|||. ...   .  .| |.| ||.    |.||| .|  . .   | .| |  ..    |.|||||..|..  .|.| | .|    |. .
knlkknqsedvpildsnlvkleaepds....yvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlsel

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 445-557 3.1e-07 24.1 In-house 165-273 (302) alignment
Range on Protein: 445-557
Range on HMM: 165-273/302.0
TLKKTNGVIVSEINFNPKTGEVR-QISHFMYLEWTEHAVPTKLLTIIDLIGDLQKarrkhLDRPVVVHCSDGVGRTGAFCTLFATLERVKLEGVLDVFIT
| ||.  .   ||. . |. .|.  .. ...  | .|  | .  | .|..   .        . |.|||| ||||||.. ..   ..  . . | |.   
tdkksfklytveiknekkkkkvkktvdilafsawpdhGapkeaytaldilkfces.....ykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsi

ARMLRTQRPGMVSH
   .|. | | | .
vlpvrqcryGavqd

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 52-93 3.3e-07 24.2 In-house 39-78 (244) alignment
Range on Protein: 52-93
Range on HMM: 39-78/244.0
NKPKNRYGNIKAYDHSRVILSSVQgdSESTDYINANWIDGFK
|  |||| ||  .|..|||||| .   |..||||||.|.| .
natknryinilpfdetrvilsssk..kegsdyinanyiqgsq

subfamily_PTPDC1_pd Subfamily PTPDC1 186-279 3.6e-07 24.8 In-house 84-168 (182) alignment
Range on Protein: 186-279
Range on HMM: 84-168/182.0
HFYFTSWPDHDVPEYaTGLLEFWKRVRNSWegpQSGPITVHCSAGVGRTGTFIVIDAMMEQikEenlLDVYSYVSRIRAQRNFMVQRPSQYSFI
 .|  .|.|..|.   . .|.  | |  .    | | ..||| || ||||  |    .  .  .   |.    .. .|..|   .|  .|  ..
yvynfgwkDygvasl.eriLdivkvvafal...qegkvavhChaGlGrtGvliacylvyak..r...ltaekaiklvrskrpksiqtreqvelv

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 370-425 5.1e-07 24.1 In-house 11-66 (130) alignment
Range on Protein: 370-425
Range on HMM: 11-66/130.0
EDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCGLNEPL
.. ||||||..   .    .. ||.|| .|  |||.|. .  |  .|.|  ..|  
qgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed

0038934 (Phosphotyrosine protein) phosphatases II 473-566 5.6e-07 24.9 In-house 83-171 (194) alignment
Range on Protein: 473-566
Range on HMM: 83-171/194.0
MYLEWTEHAVPTKLLTIIDLIGDLQKARRKHLDRPVVVHCSDGVGRTGAFCTLFATL-ERVKLEGVLDvfitarMLRTQRPGMVSHLDQYRLCYE
. | . .. ..  | .. . .  ...  ... .  |.|||  |.|||| ..  .     . ..|  ..      ..|  |||.. . |...  ..
lklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAia......lfrekRpgaipnqdyleallk

PTEN_1 191-281 6.5e-07 24.3 In-house 101-187 (196) alignment
Range on Protein: 191-281
Range on HMM: 101-187/196.0
SWPDHDVPEYAtGLLEFWKRVRNSWE-GPQSGPITVHCSAGVGRTGTFIViDAMMEQIKeENLLDVYSYVSRIRAQRNFMvqRPSQYSFIHY
...|| .|  .  |... |.. ...   |. . . ||| ||.||.|| .    .|.  |  .  .  ..| . | ....    |||  ...|
pieDhgapsls.elfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva.ayLmykgk.ltadeAlelvrekRppgapn..spsqerlley

PTPc_motif_SM00404 218-264 6.5e-07 24.3 In-house 78-122 (140) alignment
Range on Protein: 218-264
Range on HMM: 78-122/140.0
PQSGPITVHCSAGVGRTGTFIVIDAMMEQikEENLLDVYSYVSRIRA
 . | . ||| ||| |..|.|.   |...  . .| ..|..|.. | 
kkggkvlVHCqaGvSRSatliiaYlmryr..qlslaeayefvkerRp

subfamily_eak_pd Subfamily eak 346-484 7.6e-07 22.8 In-house 54-196 (332) alignment
Range on Protein: 346-484
Range on HMM: 54-196/332.0
KKNrYPNILPCERCRVVLPAIpDKEDTTYINASYLEGYQEKVAFIATQAPLDNTIEDFWRMVWHEEVFCIVMLCG-LNEPLEVF---FSAIYTYlcWWGG
..|   .|.| .|  | | .   ..   ||||| .|  .    .| | .. .. .  ||.||  .   .||.|   ... || .   |         .  
nrn.vvkivpydrylvrltss.qlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktre..elkf

GRWTLKKTNG---VIVSEINFNPKTG-EVRQISHFMYLEWTEHAVPT
| . ... .     |.   ..  . | |  .. |. .  ||| ..| 
GildverkefvkrniletrllelskGnethrvlhykvfGwtettlpk

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 338-382 1.9e-06 21.5 In-house 41-85 (440) alignment
Range on Protein: 338-382
Range on HMM: 41-85/440.0
TATQPKNSKKNRYPNILPCERCRVVLPAIPDKEDTTYINASYLEG
 |. |.|  |||| |||  ...||.|  .    |. ||||||..|
iaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasying

DSPc Dual specificity phosphatase, catalytic domain 219-265 3.8e-06 21.8 Pfam-A 72-116 (133) alignment
Range on Protein: 219-265
Range on HMM: 72-116/133.0
QSGPITVHCSAGVGRTGTFIVIDAMMEqiKEENLLDVYSYVSRIRAQ
. . . ||| ||. |..|.|.   |..  |. .| . |..|.. | .
kgkkvlVHCqaGisRSatliiaYlmkt..knlslneAyefvkerrsk

DSPc Dual specificity phosphatase, catalytic domain 219-265 3.8e-06 21.8 In-house 72-116 (133) alignment
Range on Protein: 219-265
Range on HMM: 72-116/133.0
QSGPITVHCSAGVGRTGTFIVIDAMMEqiKEENLLDVYSYVSRIRAQ
. . . ||| ||. |..|.|.   |..  |. .| . |..|.. | .
kgkkvlVHCqaGisRSatliiaYlmkt..knlslneAyefvkerrsk

PTEN_1 474-521 6.4e-06 21.1 In-house 99-146 (196) alignment
Range on Protein: 474-521
Range on HMM: 99-146/196.0
YLEWTEHAVPTkLLTIIDLIGDLQKARRKHL-DRPVVVHCSDGVGRTGA
 .... | .|. |  ..| . ..  .....   . |.|||  |.||.| 
hfpieDhgaps.lselfdicksfiewllsdpngnvVlVHCkaGlgRsGt

subfamily_DSP10_pd Subfamily DSP10 222-264 9.8e-06 19.5 In-house 94-134 (159) alignment
Range on Protein: 222-264
Range on HMM: 94-134/159.0
PITVHCSAGVGRTGTFiVIDAMMEQiKEENLLDVYSYVSRIRA
 . ||| ||. |  |. ||  .|.. .. .| | | .|.  |.
rvLvhCqaGisrsatv.viaYlmkh.lnlslndaykfvkekrp