Gene NvecPTP-Un-1 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP068_AA protein Get Run
NvecP068_AA_0-259 phosphatase_domain Get Run
NvecP068_AA_270-544 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 8-285 2.1e-117 388.1 In-house 35-308 (564) alignment 
Range on Protein: 8-285
Range on HMM: 35-308/564.0
GPRATFEAAQTPYNKTKNRYPNILPYDHSRVVLRARKDSHGSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCE
|.. |.|||. | || |||| ||..||||||||.. .  .|||||||.|.|||  ...|||.|||| |||.||||..||. ..|||||  .| | .  |.
gqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkch

RYWPEDGHQEYGDVAVSVVDVTHMTDWTVRTFLVwvrLHPECMDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRYHLsSEETGPILVHCGAGVGRTGT
.||||.|...||.. |.... ....| ..||| .    . . ...|||.||.||.|||.||||....|. . .| | .  ....|||.||| ||||||||
kYWPekgtetygeltVtleeeeeladyeirtfkl...kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGt

FIAIDSLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLRDASLCGITEIPSQEIASSLLVLRDNDPDII
||.||......  |..||.|..|...|.|||.||||.|||.||.... .|  || ||..|... . |  |.  ..|  
fividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLaeveedte
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 9-287 1.3e-104 344.7 In-house 34-309 (318) alignment 
Range on Protein: 9-287
Range on HMM: 34-309/318.0
PRATFEAAQTPYNKTKNRYPNILPYDHSRVVLRARKDSHGSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCER
  .|   . .| ||.|||| |||.|||.|| |. .....||||||||..|||   ..|||||.||.|||.||||..||.....|||| ..| . .  ..|
etvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhr

YWPEDGHQEYGDVAVSVVDVTHMTDWTVRTFLVWvrlHPECMDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRYHLSSEETGPILVHCGAGVGRTGTF
|||..| ..||.. | . . ....|...|.| |    . |. ..|.| |...|.|||.||||..| |. .  . ..   ....|||.||| |||||||.|
yWPskgsrsygklvvelkeevelsdyvlrefkvt...rteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvf

IAIDSLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLRDASLCGITEIPSQEIASSLLVLRDNDPDIIRQ
||.|.|....  |..|||...| |.|.||| ||||..|| |||||| .|  .| ||. .....| .  ||..||.. . 
iavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelreqdpesgtt
subfamily_PTPRB_pd Subfamily PTPRB 1-256 3e-97 320.2 In-house 31-283 (293) alignment 
Range on Protein: 1-256
Range on HMM: 31-283/293.0
FQSLSHLGPRATFEAAQTPYNKTKNRYPNILPYDHSRVVLRARKDSHGSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEH
...|...|   . .||... |..|||| |||||||||| | | ||..||||||||...|| .|...||.|||| ||..||||..||| ...|||| ..  
yeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlve

KLRSDCERYWPED-GHQEYGDVAVSVVDVTHMTDWTVRTFLVWVrlhpeCMDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRYHL-SSEETGPILVHC
| .  ||.|||.|   . |||. |..|  ....||..|....        ...|.|.|..||.||| ||||.|..|. | .. | .. ......||.|||
kgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek.....ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhC

GAGVGRTGTFIAIDSLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLRD
 |||||||||||.| |....  | .||..|.||..|..||..||| .|| ||.... |
saGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvld
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 2-283 2.9e-96 317.3 In-house 30-308 (319) alignment 
Range on Protein: 2-283
Range on HMM: 30-308/319.0
QSLSHLGPRaTFEAAQTPYNKTKNRYPNILPYDHSRVVLRARKDSHGSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHK
. |.. ..  ||. |... ||.||||.|||.||..|||| . ....|||||||.|.|||   .|.||.|.|| .||.||||..||... ..||| .   |
kllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklvek

LRSDCERYWPEDGHQEYGDVAVSVVDVTHMTDWTVRTFLVwvRLHPECMDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRYHLSSEETGPILVHCGAG
|.  ...||||  ..||| . | . .  .. |. .| . .  . . . .. |||..||.|.|||..|||..  |. . .. |   . .. ||| ||| ||
lkvklkkywpeenfeeyGrlivtleeeeeledyiirklkl..nkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaG

VGRTGTFIAIDSLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLRDASLCGITEIPSQEIASSLLVLRDNDPD
||||||||..|  ....  |||.||. .| ..|||||.|||..||| |||..|..|  .| |||  |..   |  |.....|
vGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqlaekvad
0050432 (Phosphotyrosine protein) phosphatases II 1-260 1.3e-94 312.3 In-house 48-301 (308) alignment 
Range on Protein: 1-260
Range on HMM: 48-301/308.0
FQSLSHLGPRATFEAAQTPYNKTKNRYPNILPYDHSRVVLrarkdSHGSDYINANFVDGY--GCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDT
|. | .. |  ....|. | ||.||||..|||||||||.|     ..|||||||..||||  ..|.|.||.|||| .|..||||..|| ....|||| ..
feellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtkl

EHKLRSDCERYWPED---GHQEYGDVAVSVVDVTHMTDWTVRTFLVWVRLHPecmDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRYHLsseETGPIL
. . |  |..|||..   | .|||.. | ....... |.||||. ..    .   . |.||.|..|.|||.|||.....|. | .. | .|   . |||.
vengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg...esrtvthfhytnWpdhgvPpspeilldflelvrksl...pggpiv

VHCGAGVGRTGTFIAIDSLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLRDASLC
||| |||||||||||.| |..|. .|| |||.. |...|.||..|||| ||| |.|..| .  ..
VHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
0051299 (Phosphotyrosine protein) phosphatases II 1-256 2.2e-94 311.4 In-house 29-284 (288) alignment 
Range on Protein: 1-256
Range on HMM: 29-284/288.0
FQSLSHLGPRATFEAAQTPYNKTKNRYPNILPYDHSRVVLRARKDSHGSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEH
|. | .| |  |. ||. | |..||||..|||||||||.|.  ....|||||||...||| ...|.||.|||| .|..||||..||.....|||| ... 
feellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklve

KLRSDCERYWPEDGHQEYGDVAVSVVDVTHMTDWTVRTFLVWVR-LHPECMDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRYHLSsEETGPILVHCG
. | .|..|||..|...|||. |  ...... |.||||. |    |.  .  .|.||.|..|.|||.|||... .|. | .. | .|.    ||..||| 
lgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCs

AGVGRTGTFIAIDSLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLRD
|||||||||||.| |..|.  ||.|||...|...|.||..|||| ||| |.|..| .
aGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealle
subfamily_PTPRA_pd Subfamily PTPRA 7-273 3.8e-94 310.3 In-house 44-310 (330) alignment 
Range on Protein: 7-273
Range on HMM: 44-310/330.0
LGPRATFEAAQTPYNKTKNRYPNILPYDHSRVVLRARKDSHGSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDC
   .||.|.|.   || |||..||||||.|||.|  ..  . |||||| |.|||   .|.||||||..||..||||.|||.  .||||| . . . .. |
gpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekc

ERYWPEDGHQEYGDVAVSVVDVTHMTDWTVRTFLVWvRLHPEC--MDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRyHLSSEETGPILVHCGAGVGR
..|||..|   ||.. |.| |.| . |.||| |||  .|  ..   ..| |.|| ||.||| ||| ..  .. . .| . .|   ..||| ||| |||||
aqywPdeGlvtyGnirvevedetvlvdytvrkflvq.qlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvk.klnqqsagpivvhcsaGvGr

TGTFIAIDSLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLRDASLCGITEIPSQEIASS
|||||..|......  |..|||..|| ..|.||  |||| ||| ||| ||..  | | ||.    . . 
tGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekh
subfamily_PTPRG_pd Subfamily PTPRG 12-287 1.3e-92 305.8 In-house 38-319 (563) alignment 
Range on Protein: 12-287
Range on HMM: 38-319/563.0
TFEAAQTPYNKTKNRYPNILPYDHSRVVLRARKDSHGS-DYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCERYW
. |..| | || |||| ||..||.||| |.   . ... ||||||..|||   ...||.||||..|..||||.|||.  ..|||. . ... | .|..||
daehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYW

PEDGHQEYGDVAVSVVDVTHMTDWTVRTFLVWV---RLHPECMDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRyHLSSEETGPILVHCGAGVGRTGT
|.|. ..|| . |  ..  ...  ||||. .     . . .| ....|.|...| |||.|||| ..| .|| .|       .|.|||.||| ||||||||
PkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkss.aankaeaGPivvHcsaGvgrtGt

FIAIDSLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLRDASLCGITEIPSQEIAS---SLLVLRDNDPDIIRQ
.|..|.|. |.  | .|.|.||. ..|.||||.|||.||| |..|.| .| . . ||. .... .       | ..  .||. 
yivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqveelknctpyleqqykniiqf
0040438 (Phosphotyrosine protein) phosphatases II 7-272 1.7e-92 305.3 In-house 30-290 (317) alignment 
Range on Protein: 7-272
Range on HMM: 30-290/317.0
LGPRaTFEAAQTPYNKTKNRYPNILPYDHSRVVLRARKDSHGSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDC
| .  |.. |. | || |||||.|||||||||.|   .  ..||||||..|||. ...|.||.|||| .|. ||||..|| |.|.|||| ..| . |  |
lkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekc

ERYWPEDGHQEYGDVAVSVVDVTHMTDWTVRTFLVWVRlhpECMDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRYHLSsEETGPILVHCGAGVGRTG
..|||... ..|||. | ....... ..|.||. |.     .. ..|.||.|..|.|||.|||... .|. | .. | .|. .. ||.|||| |||||||
aqYwplgetltygdftvtllseeelagitlrtlevedl...gdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtG

TFIAIDSLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLRDASLCGITEIPSQEIAS
||||.. ...|.  || |||.  |...| ||. .||| ||| |.||.|..  ....| .| .| ..
tfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselkl
0046845 (Phosphotyrosine protein) phosphatases II 7-263 9.6e-92 302.6 In-house 12-279 (284) alignment 
Range on Protein: 7-263
Range on HMM: 12-279/284.0
LGPRA--TFEAAQTPYNKTKNRYPNILPYDHSRVVLRARKDS-HGSDYINANFVDGY-----GCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDT
| .    ....|. | |..||||..|||||||||.|.  ... ..||||||..||||      ...|.||.|||| .|..||||..||.....|||| ..
ltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltel

EHKLRSDCERYWPEDG-HQEYGDVAVSVVDVTHMTDWTVRTFLVWVRlhpE-CMDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRYHLSS-EETGPIL
. . |  |..|||..|  ..|||. | ....... |.||||. .      . .   |.||.|..|.|||.|||.....|. | .. | .|.. .  |||.
vengrekcaqYwplegevltygdftvtllseevkddytvrtleltnl...gytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpiv

VHCGAGVGRTGTFIAIDSLMDQMMMEG---VVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLRDASLCGIT
||| |||||||||||.| |..|.  ||   .|||.. |...|.||..|||| ||| |.|..| .. ....|
VHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1-255 7.6e-91 299.1 In-house 27-276 (288) alignment 
Range on Protein: 1-255
Range on HMM: 27-276/288.0
FQSLSHLGPRATFEAAQTPYNKTKNRYPNILPYDHSRVVLRARKDSHGSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEH
..||. |.   . .|.. . |..||||.||||||. || |.  .. .|.|||||...||..  .||||.||||..|..|||.|..|.  .||||| .   
ynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelve

KLRSDCERYWPEDGH-QEYGDVAVSVVDVTHMTDWTVRTFLVWvrlhpECMDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRYHlSSEETGPILVHCG
. .. ||.|||.... ..||.| | .|.. ...|...|..|.        ....|.||.|..||||.||||..|||. . ..     ....||||.||| 
ggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle.....kkkteleitqyqylaWpdhgvPeskapllellrqvkva.nqadtgpiivhCs

AGVGRTGTFIAIDSLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLR
|||||||||||.| |.|..  | ..|| |.||..| ||...||| .|| |||.|| 
aGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
0036941 (Phosphotyrosine protein) phosphatases II 2-269 1.5e-90 298.8 In-house 20-288 (297) alignment 
Range on Protein: 2-269
Range on HMM: 20-288/297.0
QSLSHLGPRATFEAAQTPYNKTKNRYPNILPYDHSRVVLrarkDSHGSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHK
..| .| .  ....|. | |..||||..||||||.||.|    |. |||||||..||||....|.||.|||| .|. ||||..|| ..|.|||| . . .
eellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvel

LRSDCERYWPED--GHQEYGDVAVSVVDVTH--MTDWTVRTFLVWVRlhpECMDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRYHLSSE-ETGPILV
 |  |..|||..  . ..|||. | ...|..   .|.|.||. |.     .. ..|.||.|..| ||| ||||..|.|. | .. | .|.   . ||.||
grekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt...gngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlV

HCGAGVGRTGTFIAIDSLMDQMM---MEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLRDASLCGITEIPSQE
|| |||||.|||||.| ...|.    .|| ||.. .| ..|.||...||| ||| |.|..| .  ... | .| ..
HCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllk
0047943 (Phosphotyrosine protein) phosphatases II 1-255 8.2e-90 296.2 In-house 18-269 (273) alignment 
Range on Protein: 1-255
Range on HMM: 18-269/273.0
FQSLSHLGPRATFEAAQTPYNKTKNRYPNILPYDHSRVVLrarkDSHGSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEH
|. |  | |  |...|. | ||.||||..|||||||||.|    .. |||||||..|||| ...|.||.|||| .|..||||..||.....|||| ... 
felllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelve

KLRSDCERYWPEDG---HQEYGDVAVSVVDVTHMTDWTVRTFLVWVRLHPEcmdKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRYHLSSE-ETGPILV
. | .|..|||..|   ...||.. | ......  |.||||. ..    .|   .|.||.|..| |||.|||.....|. | .. | .|..  . ||..|
lgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge...srtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvV

HCGAGVGRTGTFIAIDSLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLR
|| |||||||||||.| |.||. .|| |||.  |...|.||  |||| ||| |.|..| 
HCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyeall
0039614 (Phosphotyrosine protein) phosphatases II 13-260 1.5e-87 289.1 In-house 48-291 (297) alignment 
Range on Protein: 13-260
Range on HMM: 48-291/297.0
FEAAQTPYNKTKNRYPNILPYDHSRVVLRARKDS-HGSDYINANFVDGYGC-PQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRsDCERYW
.. |. | ||.||||..|||||||||.|   ... ..||||||..|||| . ..|.||.||||.||..||||..|| |.|.|||| ... . |  |..||
ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqyw

PEDGHqEYGDVAVSVVDVTHMTDWTVRTFLVWVrlhPE-CmdkREVTQFQFTAWPDQGVPENTAPLIIFHHKYRYHLSSE-ETGPILVHCGAGVGRTGTF
||.|  .|||. | ...|.|  ..||||. |.     .     |.||.||.| ||| |||.... |. | .. | .|..  . ||.|||| |||||||||
peegg.tygdftvtllkvehldgytvrtlevtn...nges...rtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtf

IAIDSLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLRDASLC
||.. ...|.  || |||.  |...| ||. .||| .|| |.||.|..  ..
iaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
0043336 (Phosphotyrosine protein) phosphatases II 3-255 1.2e-86 285.9 In-house 28-274 (278) alignment 
Range on Protein: 3-255
Range on HMM: 28-274/278.0
SLSHLGPrATFEAAQTPYNKTKNRYPNILPYDHSRVVLRARKDSHGSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKL
.| .  .  |.. |. | ||.||||..|||||||||.|   .   .||||||..|||| .|.|.||.||||.||..||||..|| |.|||||| . . . 
ellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelg

RSDCERYWPeDGHQEYGDVAVSVVDVTHMTDWTVRTFLVWVRLHPECmdkREVTQFQFTAWPDQGVPENTAPLIIFHHKYRYHLSsEETGPILVHCGAGV
|  | .||| .|...|||. | .....|. |.||||. |. . ..|.   |.||......|||.||||....|. | .. | .|.  . ||.|||| |||
rvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdges...rtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGv

GRTGTFIAIDSLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLR
||||||||.. |..|.. || ||..  |...|.||  .||| .|| |.|..|.
gRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall
subfamily_PTPRK_pd Subfamily PTPRK 13-282 1.9e-86 284.8 In-house 35-301 (314) alignment 
Range on Protein: 13-282
Range on HMM: 35-301/314.0
FEAAQTPYNKTKNRYPNILPYDHSRVVLRARKDSHGSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCERYWPE
..||.   |..|||. .||.||.|||.| . ..   ||||||...|.|  |...|..|||| ||.||||||.....|..|||| .  .. |  | .||||
wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPe

DGHQeYGDVAVSVVDVTHMTDWTVRTFLVWvRLHPECMDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRYhLSSEETGPILVHCGAGVGRTGTFIAID
|... |||. | .|...  ..  ||.| |  .|.    ..||| ||||..||| .|| .   |. . ..     . || |.|.||| || ||||||||||
dtev.ygdikvelvetellaelvvrifrve.klargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkk.sqeeeaGrivvhCsaGaGrtGtfiaid

SLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLRDASLCGITEIPSQEIASSLLVLRDNDP
...| .  ||||||.  | ..|...  ||.|.||| |||||. .| ||| | ||  |. .  |     ||
ivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalylesirldp
DSPc_SM00195 2-255 4.2e-86 283.9 In-house 7-259 (263) alignment 
Range on Protein: 2-255
Range on HMM: 7-259/263.0
QSLSHLGPRATFEAAQTPYNKTKNRYPNILPYDHSRVVLRARKDSHGSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHK
..|    .  ... |. . ||.|||| |||||||.|| |  .... ||||||||...|. ...||||.|||| .|..||||..||.....|||| . | .
ekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeen

LRSDCERYWPED--GHQEYGDVAVSVVDVTHMT-DWTVRTFLVWVRLHpecMDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRYHLSSEeTGPILVHC
 .  |.|||||.  | ...|.. | .|.|...  ....||. .    .    ..|.|||.|...|||.|||..| ... . .. . . |.. .|||.|||
gkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk...eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhC

GAGVGRTGTFIAIDSLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLR
 |||||||||..||...... .|  ||.   | ..|.||  ||||.|||.|||... 
saGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeail
PTPc_SM00194 2-255 4.2e-86 283.9 In-house 7-259 (263) alignment 
Range on Protein: 2-255
Range on HMM: 7-259/263.0
QSLSHLGPRATFEAAQTPYNKTKNRYPNILPYDHSRVVLRARKDSHGSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHK
..|    .  ... |. . ||.|||| |||||||.|| |  .... ||||||||...|. ...||||.|||| .|..||||..||.....|||| . | .
ekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeen

LRSDCERYWPED--GHQEYGDVAVSVVDVTHMT-DWTVRTFLVWVRLHpecMDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRYHLSSEeTGPILVHC
 .  |.|||||.  | ...|.. | .|.|...  ....||. .    .    ..|.|||.|...|||.|||..| ... . .. . . |.. .|||.|||
gkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk...eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhC

GAGVGRTGTFIAIDSLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLR
 |||||||||..||...... .|  ||.   | ..|.||  ||||.|||.|||... 
saGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeail
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 9-265 8.3e-86 282.9 In-house 44-297 (298) alignment 
Range on Protein: 9-265
Range on HMM: 44-297/298.0
PRATFEAAQTPYNKTKNRYPNILPYDHSRVVLRARKDSHGSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCER
.... |.|..|.|| ||||..|...|.|||||.. .. . |||||| |...|   . .||.|.|||||..||||...|.  .||||| ..| . . ....
eeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhk

YWPEDGHQEYGDVAVSVVDVTHMTDWTVRTFLVWVRLHPecmDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRYHLSSEETGPILVHCGAGVGRTGTF
|||..|...||.. ||.    ...| .||.. |  . .    ..||| |..|| |||.|||||.  .. . .| | . .     |..|.| |||||.|||
ywPdegketygeitvsllskeefadlivrklkvskkkee...kerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtf

IAIDSLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLRDASLCGITEI
|||||.....  | ||||.  |  .|..|  .|||.|||.|||..  .|  .. .||
iaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
0045450 (Phosphotyrosine protein) phosphatases II 11-255 2.1e-85 282.4 In-house 45-301 (307) alignment 
Range on Protein: 11-255
Range on HMM: 45-301/307.0
ATFEAAQTPYNKTKNRYPNILPYDHSRVVLRARKDS-HGSDYINANFV--------DGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHK
 ....|. | ||.||||..||||||.||.|   ..| ..||||||..|        ||| ...|.||.|||| ||..||||..||.|.|.|||| ... .
geysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvel

LRSDCERYWPEDGHQ-EYGDVAVSVVDVTHMTDWTVRTFLVWVRlhPECMDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRYHLSSE-ETGPILVHCG
 |  | .|||..|.. .||.. | .....|. ..||||. |.     ..   |.||.|..|.|||.|||.....|. | .. | .|..  . ||.|||| 
grekcaqywPdegeeltygnftvtllseehldgytvrtlevtdl..dgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCs

AGVGRTGTFIAIDSLMDQMMMEGV---VDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLR
|||||||||||.. ...|.  ||.   ||..  |...| ||  .||. ||| |.|..|.
aGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeall
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 13-267 4.6e-85 280.3 In-house 41-288 (315) alignment 
Range on Protein: 13-267
Range on HMM: 41-288/315.0
FEAAQTPYNKTKNRYPNILPYDHSRVVLRARKDSHGSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCERYWPE
.. |.   || |||| ||..||.||| |   .   .|||.||||.|||  ...|||||||.....||||||..|. ...|||| .. .. .. .|.|||.
ldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpd

DgHQEYGDVAVSVVDVTHMTDWTVRTFLVWVRlhpecMDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRYHLSSEEtGPILVHCGAGVGRTGTFIAID
. .  || ..|. ..  . |..||||. | ..      . ||| |...|.||| |||. | ||. .. . . |  ..  |.|.||| ||||||||||..|
k.kviyGkitvtrkseevnteytvrtlsvvfg.....dnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitld

SLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLRDASLCGITEIPS
...||. .| ..||| |. ..| .|  |||. ||| ||||.| .. .|| | |  
avldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaq
subfamily_Ptp69D_pd Subfamily Ptp69D 13-273 4.8e-84 277.1 In-house 40-301 (307) alignment 
Range on Protein: 13-273
Range on HMM: 40-301/307.0
FEAAQTPYNKTKNRYPNILPYDHSRVVLRARKDSHGSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCERYWPE
 ....   |. ||||..| ..|. ||.|.  . .. ||||||.|. ||   .|.||||.|. .||.||||.|.|.  |.|||| . . | | .|..|||.
tkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpi

DGHQEYGDVAVSVVDVTHMTDWTVRTFLVWVRL--HPECMDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRYHlSSEETGPILVHCGAGVGRTGTFIA
.  ..|||. | .|.  ...|.. |.. |       .|  |.|.|.|...|.|.|  ||| .  |. . .. | .  . . .||.||| |||||.|.|.|
edevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrel.yklnrsPivvhCsaGvgrsgifva

IDSLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLRDASLCGITEIPSQEIASS
.|||..|.  |  ||.. .| ..| |||..||  ||| |.|  | | |  | |..  ......
ldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddleda
0040439 (Phosphotyrosine protein) phosphatases II 12-256 1.1e-83 275.9 In-house 2-244 (249) alignment 
Range on Protein: 12-256
Range on HMM: 2-244/249.0
TFEAAQTPYNKTKNRYPNILPYDHSRVVLRARKDSHGSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCERYWP
... |. | || |||||.|||||||||.|   ..  .||||||...||| .....||.||||.||..||||..|| |.|.|||| ... . | .|..|||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

EDGHQEYGDVAVSVVDVTHMTDWTVRTFLVWVRlhpECMDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRYHLSSE-ETGPILVHCGAGVGRTGTFIA
..|..||||. | ...|... |.||||. ..     .. ..|.|...|.| |||.|||.....|. | .. | .|..  . ||.|||| |||||||||||
lggsleygdftvtllsvevkddytvrtleltnl...ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfia

IDSLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLRD
.. ...|.  |. ||..  |...|.||. .||. ||| |.|..|..
aylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 13-270 1.1e-82 272.6 In-house 38-295 (305) alignment 
Range on Protein: 13-270
Range on HMM: 38-295/305.0
FEAAQTPYNKTKNRYPNILPYDHSRVVLRARKDSHGSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCERYWPE
..  ..  ||.|||. .| ..|..|. |..... . ||||||..||||   .|||.||||| .|..||||||.|   .||||| ..    .. |..||||
idvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpe

DGHQ--EYGDVAVSVVDVTHMTDWTVRTFLVWVRLHpeCMDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRYHLSSEETGPILVHCGAGVGRTGTFIA
   .  |.|.. | . . ....|.. | . . .. .    ..| |.|.|.| |||.|||. .. |. . .. . . ....  |.|||| |||||||.|||
sktekkefgefsvelksektasdyieRklkisiede..dkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfia

IDSLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLRDASLCGITEIPSQEI
.|  ....  |.||||.. . |.|..|  |||| .|| |..|.| .   || |.|  . .
vdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnl
0042113 (Phosphotyrosine protein) phosphatases II 14-255 7.6e-82 269.7 In-house 2-240 (245) alignment 
Range on Protein: 14-255
Range on HMM: 2-240/245.0
EAAQTPYNKTKNRYPNILPYDHSRVVLRARKDSHGSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCERYWPED
. |. | ||.||||..||||||.||.|   . . .||||||..|||| ...|.||.||||.||..||||..|| |.|||||| ..| . | .|..|||..
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

GHQEYGDVAVSVVDVTHMTDWTVRTFLVWVRlhpECMDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRYHLSSEETGPILVHCGAGVGRTGTFIAIDS
....|||. | .....|. |.||||. |.      .  .|||...... |||.|||.... |. |..  | .|.. . ||.|||| |||||||||||.. 
esltygdftvtllseehlddytvrtlevtnl...gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaayl

LMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLR
...|.  |. |...  |...| ||  .||| .|| |.|..|.
mleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1-257 7.9e-82 269.5 In-house 21-275 (281) alignment 
Range on Protein: 1-257
Range on HMM: 21-275/281.0
FQSLSHLGPRATFEAAQTPYNKTKNRYPNILPYDHSRVVLRARKDSHGSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEH
...|...| . | .|.... |..|||| ||  ||..||..   .... .||||||||.||  ...|||.|||. .....||...||.  ..|||.    .
yeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreie

KLRSDCERYWPEDG-HQEYGDVAVSVVDVTHMTDWTVRTFLVwvrlHPECMDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRYHLSSEETGPILVHCG
. .  | ||||.|  . .|||| |. .  .. . .  |.| .    . |  ..|||.|...|||||.|||..|. |. |... .   ....  |...|| 
agklkChrYWPddnselkygdvtvkstaeeekatyierkfkl....eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCs

AGVGRTGTFIAIDSLMDQM-MMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLRDA
||||||||.||.| |....  ..  .||   ||..| .||.||||  ||.|.| .. ||
aGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavlda
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 6-266 4.5e-81 267.6 In-house 45-299 (319) alignment 
Range on Protein: 6-266
Range on HMM: 45-299/319.0
HLGP-RATFEAAQTPYNKTKNRYPNILPYDHSRVVLRARKDSHGSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGdtehklRS
.||.  |. . |  . || |||. |||..|...| |.      .|||||| ||.||  ..||||||||| .|..||||.|||  |.|||.|       . 
klgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kd

DCERYWPEDGHQEYGDVAVSVVDVTHMTDWTVRTFLVWVrlHPECMDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRyHLSSE--ETGPILVHCGAGV
 | .||| .. ....   |.|  |.   ...|| . .    . .  |.|..||| |  |||.|||. ...|. . .| | || |   .  .|.||| |||
kcsqywplkivikeerfkvkvdsveetaeyvvrdielse..dgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvr.hltskenhranivvhcsaGv

GRTGTFIAIDSLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLRDASLCGITEIP
||||..|..| |.|.|  |  |||| || ..| ||| .||   || |||  | .  | | ... 
GrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdva
0045098 (Phosphotyrosine protein) phosphatases II 7-256 6.2e-81 267.1 In-house 19-270 (278) alignment 
Range on Protein: 7-256
Range on HMM: 19-270/278.0
LGPRATFEAAQTPYNKTKNRYPNILPYDHSRVVlrarkdshgsDYINANFVDGYgcPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDC
||.  ... |. . |. ||||..|||||||||.          |||||...|||  |.|.||.|||| .|. ||||..|| |.|.|||| . ... |  |
lgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekc

ERYWPEDGHQEYGDVAVSVVDVTHMTDWTVRTFLVWVR-LHPECMDKREVTQFQFTAWPDQGVPENT--APLIIFHHKYRYHLS------------SEET
..||||.|...|||. | ....... |.|.||.||.   ...|   .|.||..... ||| |||...  .... .    | .|.             .. 
aqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsg

GPILVHCGAGVGRTGTFIAIDSLMDQMmmEGVVDVYGFVAQMRTQRNF-MVQTHEQYAFIYDVLRD
||.|||| ||||||||..|.. .....  ||.||..  |...|.||.. .||. ||| |.|..|..
gpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyeflle
Y_phosphatase Protein-tyrosine phosphatase 21-254 1.6e-80 265.3 Pfam-A 1-233 (235) alignment 
Range on Protein: 21-254
Range on HMM: 1-233/235.0
NKTKNRYPNILPYDHSRVVLraRKDSHGSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCERYWP--EDGHQEY
||.||||..|||||..|| |  ..... |||||||.|.||  ..|.||.|||| .||.||||..|.. ...|||| . | | |  |..|||  |.. ..|
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GDVAVSVV-DVT-HMTDWTVRTFLVWVRLHPEcmDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRYHLsSEETGPILVHCGAGVGRTGTFIAIDSLMD
||. | .. ... .....|.|.. .  . ...  .||||.|...|.|||.||||.. .|. . .| . .  ....||..||| |||||||||.|.| |..
gdikvelkekekedekeytlrklelkkkkees..ekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldille

QMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVL
|.  |. |||. .| ..|.||. |||. |||.|.|...
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 21-254 1.6e-80 265.3 In-house 1-233 (235) alignment 
Range on Protein: 21-254
Range on HMM: 1-233/235.0
NKTKNRYPNILPYDHSRVVLraRKDSHGSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCERYWP--EDGHQEY
||.||||..|||||..|| |  ..... |||||||.|.||  ..|.||.|||| .||.||||..|.. ...|||| . | | |  |..|||  |.. ..|
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GDVAVSVV-DVT-HMTDWTVRTFLVWVRLHPEcmDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRYHLsSEETGPILVHCGAGVGRTGTFIAIDSLMD
||. | .. ... .....|.|.. .  . ...  .||||.|...|.|||.||||.. .|. . .| . .  ....||..||| |||||||||.|.| |..
gdikvelkekekedekeytlrklelkkkkees..ekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldille

QMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVL
|.  |. |||. .| ..|.||. |||. |||.|.|...
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 6-266 4e-80 264.4 In-house 9-263 (284) alignment 
Range on Protein: 6-266
Range on HMM: 9-263/284.0
HLGP-RATFEAAQTPYNKTKNRYPNILPYDHSRVVLRARKDSHGSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGdtehklRS
.||.  .. . |  . || |||. .||..|...| |.      .|||||| |. ||  ..||||.|||| .|..||||.|||  |.|||.|       . 
klgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kd

DCERYWPEDGHQEYGDVAVSVVDVTHMTDWTVRTFLVWVRLHpeCMDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRyHLSS--EETGPILVHCGAGV
 | .||| .. ....   |.|  |.   ...|| . .    .    |.|...|| |  |||.|||. ...|. . .| | ||.|  ..  .|.||| |||
kcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgk..ekdirkirqfhflgwpdvgvpdypsdlmrlvkkvr.hltskenhranivvhcsagv

GRTGTFIAIDSLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLRDASLCGITEIP
||||..|..| |.|.|  |  |||| || ..| ||| .||   || |||  | .  | | ... 
grtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdva
subfamily_PTPRD_pd Subfamily PTPRD 326-544 8.8e-79 260.6 In-house 57-282 (564) alignment 
Range on Protein: 326-544
Range on HMM: 57-282/564.0
FVAVDTNRIRLSITNDIPCSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRDGCVRYGKYIVTKIDEE
 || |..|..|| ..  . |.|||||.||.|.. ..|||||.|...||..||.|||||... |||||.|...|. . . ||| .|  .||...||  .||
ivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeee

ELDDHTQR--------SMDSLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKIQsTEDHGPTVVHCSDGAGRTGVFLALAISIERLEAEDTVDIFQTVRW
|| | . |        |..|  | .|.. .|  ||.|   ..|. | ..|.... ..|.||.||||| | ||||.|... . .||...|.||||.|.|. 
eladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvka

LRSQRPALVGSIEQYSCCYQAVKSYLS
||.||.|.| . |||. ...|.  .|.
lrkqRnamVqteeQYiFiheaileala
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 16-260 4.1e-78 257.0 In-house 4-244 (250) alignment 
Range on Protein: 16-260
Range on HMM: 4-244/250.0
AQTPYNKTKNRYPNILPYDHSRVVLRARKDSHGSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSdCERYWPEDGH
|. | || |||| .|...|.|||||   |  . |||||| |..||   . .||.||||..||.||||...|.  .||||| . . . .  ...||| .. 
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPveka

QEYGDVAVSVVDVTHMTDWTVRTFLVWVRlhpECMDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRYHLSSEETGPILVHCGAGVGRTGTFIAIDSLM
..|||| ||. .  ...|.|.|.. .  .   .  |.| | |..|..|||.||||..   . . .| .      ...|..|.| |||||.|.|||||...
ekyGdvtvsllskeefadytkrklklska...kkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavl

DQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLRDASLC
...  | ||||. .. ..|..|  .|...||| |.| ..  |  .
erlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
0051299 (Phosphotyrosine protein) phosphatases II 264-543 1.3e-77 256.4 In-house 4-286 (288) alignment 
Range on Protein: 264-543
Range on HMM: 4-286/288.0
EIPSQEIASSLLVLRdndPDIIRQRQDEFEVSLACVASvsvfsRNRERTRNMAAPKRSDNFSFVAVDTNRIRLSITNDIPCSEYINASYIDSYNEAHEYI
||. .|... .| |.   .. . . ..|||  |.. ..     ...  ..  .  ..  . .... | .|..|| ..... | |||||||| ||  ...|
eisveellklvlkll...angltglleefeellsllpd.....ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfI

ATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRDGCVRYGKYIVTKIDEEELDDHTQRSMDSL------------LVYHFQYHNWSAH
|||.|..||...||.|||||... |||||.|...|.. .. ||| .|.. ||.. || ..||.||| |.| .                |.||.|.||  |
atqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdh

GMPPRMNGLVFLHEQVQKIQStEDHGPTVVHCSDGAGRTGVFLALAISIERLEAEDTVDIFQTVRWLRSQRPALVGSIEQYSCCYQAVKSYL
|.|. .. |. . ..|.| ..  ..||.|||||.| ||||.|.|| . .|.||.| .||....|..||.||| .| . |||  .|.|.  ||
gvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_PTPN9_pd Subfamily PTPN9 7-253 4.8e-77 253.9 In-house 28-285 (297) alignment 
Range on Protein: 7-253
Range on HMM: 28-285/297.0
LGPRATFEAAQTPYNKTKNRYPNILPYDHSRVVLRARKDSHGSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDC
  .  ||.|.... | .|||| ..| ||..||||  ... . ||||||||||||  .. .||.|||| .|..||||..||. . .|||   .. . |  |
epveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkc

ERYWP--EDGHQEYGDVAVSVVDVTHMTDWTVRTFLVWvrlHPECMDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRYHLSS-------E-----ETG
 .|||  |.  .|.||. ||.|.| .. |..||.. .    . .  ..|.|| |||..||| |||...| |. . .| | . ..       |     .  
gqyWpleeessaefgdlsvsnveveeeedykvrvleik...nvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgP

PILVHCGAGVGRTGTFIAIDSLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDV
||.||| ||.|||||||..|  .... ..|.|||   | ..|||| |..|| |||.| |  
PivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcyla
subfamily_PTPN6_pd Subfamily PTPN6 12-255 6.4e-77 253.6 In-house 43-294 (306) alignment 
Range on Protein: 12-255
Range on HMM: 43-294/306.0
TF--EAAQTPYNKTKNRYPNILPYDHSRVVLRaRKDSHGSDYINANFVD--GYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCE
..  . .. | ||.|||| ||||.||.||.|. ...  ||||||||...    |  ..|||.|| |..|..||||..|.. .. |||.     . .. | 
llsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCa

RYWPEDGH-QEYGDVAVSVVDVTHMTDWTVRTFLVWVRlhPECMDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRYHLSS---EETGPILVHCGAGVG
||||.  . .|||.. |. |. ....|...|...|  .   .  ..||| |..|..|||.|||...  .. | .. . . ..   .|.|||.||| ||.|
rYWPdeeekeeyGkisvtnvseksladYilRelsvskk..kkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiG

RTGTFIAIDSLMDQMMMEGV---VDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLR
|||||| || |..... .|.   .|.. .| ..|.||. .|||..|| |.| ...
RtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaik
subfamily_PTPN12_pd Subfamily PTPN12 14-256 1.3e-76 252.3 In-house 33-275 (290) alignment 
Range on Protein: 14-256
Range on HMM: 33-275/290.0
EAAQTPYNKTKNRYPNILPYDHSRVVLRARKDSHGSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCERYWPED
||.....|..|||| .|||||.|||.|.  ....|||||||||. |   ...||||||||..|..||||.||||  . .||.       .  ||||||| 
eagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpee

GHQE--YGDVAVSVVDVTHMT-DWTVRTFLVWVRlhpecMDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRYHLSsEETGPILVHCGAGVGRTGTFIA
|..|  .|.. |.. .  ... |...||. | ..      ..|.|.||..|||||.|||... .|. . .. | . . .|  |..||| |||||||| ||
geeelefgefevtleeekavdddflirtLkveaq.....kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiia

IDSLMDQMMMEGV---VDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLRD
||   ...  | .   .||.  |...|.||. .|||.||| ..|  . .
idyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavae
0037934 (Phosphotyrosine protein) phosphatases II 13-255 4.3e-76 250.9 In-house 2-239 (243) alignment 
Range on Protein: 13-255
Range on HMM: 2-239/243.0
FEAAQTPYNKTKNRYPNILPYDHSRVVLrarkdsHGSDYINANFVDGYGcpqKYIAAQGPLTETIKD----FWRLIWEKGCTTIVMLGDTEHKLRSDCER
|  |. |.|..||||..|||||||||.|       ||||||||......   ..|| ||||.||..|    |||..|| |.|.|||| ... . | .|..
fsiallpenlsknrysdilpydhsrvkl......egsdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPeDGHqEYGDVAVSVVDVTHMTDWTVRTFLVWVRLHPECMdkREVTQFQFTAWPDQGVPENTAPLIIFHHKYRYHLSS-------EETGPILVHCGAG
||| ... .|||. | .....|. |.||||.|..   ....   |.|.......|||.|||.....|. |... | ....        . ||.|||| ||
ywp.gev.tygdftvtllseehlddytvrtlllenldlddlt..rlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaG

VGRTGTFIAIDSLMDQMmmeGvVDVYGFVAQMRTQRNF-MVQTHEQYAFIYDVLR
||||||.||.. .....   | ||..  |...|.||.. .||| .|| |.|..|.
vgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeall
0050432 (Phosphotyrosine protein) phosphatases II 323-545 1.8e-75 249.4 In-house 74-301 (308) alignment 
Range on Protein: 323-545
Range on HMM: 74-301/308.0
NFSFVAVDTNRIRLsitnDiPCSEYINASYIDSY--NEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRD---GCVRYGKY
  .... | .|..|    | . | ||||||.| |  .  ...||||.|..||.. ||.|||||... |||||.|...|..  . ||| .   |...|||.
ykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkf

IVTKIDEEELDDHTQR--------SMDSLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKIQsteDHGPTVVHCSDGAGRTGVFLALAISIERLEAEDTV
 || ..||.|||.|.|        . .|. |.||.|.||  || || .. |. . |.|.| .   ..||.|||||.| ||||.|.|| . .|.||.| .|
tvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggv

DIFQTVRWLRSQRPALVGSIEQYSCCYQAVKSYLSW
|.|..|..||.|||  | . |||  .|.|.  ||..
dvfeavkklReqRpgmvqtpeqylflyralleylkl
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 14-266 8.8e-74 243.2 In-house 37-285 (315) alignment 
Range on Protein: 14-266
Range on HMM: 37-285/315.0
EAAQTPYNKTKNRYPNILPYDHSRVVLRARKDSHGSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCERYWPE-
 .|... | .|||| ||||.|..||.|    ||  |||||| .. .. . . |||.||||  ...||||.....  |||||. . ..  .  | .|||. 
rvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdr

-DGHQEYGDVAVSVVDVTHMTDWTVRTFlvWVRlhpECMDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRYHlSSEETGPILVHCGAGVGRTGTFIAI
     |.| . |.....   || ..| .   .|   .  ..| ||||||| |||.||...|. |. . .. .     ... ..|||| ||||||| .|.|
kadsvefGsikvellsleadtdgvarkl..vtr...kseesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvisi

DSLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLRDASLCGITEIP
|. ..|.  . .|||. || ..|..| ..|||.|.||||||....  |   | |.
devvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlil
0046845 (Phosphotyrosine protein) phosphatases II 324-546 1.6e-73 242.9 In-house 35-277 (284) alignment 
Range on Protein: 324-546
Range on HMM: 35-277/284.0
FSFVAVDTNRIRLSITND-IPCSEYINASYIDSY-----NEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRDG-CVRYGK
 .... | .|..|. ... .. |.||||||.| |     .  ...||||.|..||...||.|||||... ||||||| ..|..  . ||| .| ...||.
kdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygd

YIVTKIDEEELDDHTQR---------SMDSLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKIQST-EDHGPTVVHCSDGAGRTGVFLALAISIERLEAE
..|| ..||. ||.|.|         .  |. |.||.|..|  || || .. |. . ..|.....  ...||.|||||.| ||||.|.|| . .|.||.|
ftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqleke

D---TVDIFQTVRWLRSQRPALVGSIEQYSCCYQAVKSYLSWR
.   .||....|..||.|||  | . |||  .|.|.  ||...
glllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 15-280 2.9e-73 241.7 In-house 37-298 (515) alignment 
Range on Protein: 15-280
Range on HMM: 37-298/515.0
AAQTPYNKTKNRYPNILPYDHSRVVLRARKDSHGSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCERYWPE--
 ||   | .|||| |||||| .|| |   .|.  |||.|| .. .. . . |||.|||.  ...|||||....  |||.|. . ..  .. | .|||.  
vaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkp

DGHQEYGDVAVSVVDVTHMTDWTVRTFLVwVRlhpeCMDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRYHLsSEETGPILVHCGAGVGRTGTFIAID
    ..| . |..| .   |. . |.. | ..      | | ||||.|| |||.|||..|  |. . .. .    .. | |...|| ||||||| .|.||
gdsvkfGsikvelvsleactggikrkltv.lk....gddsrtvtqfhfteWPdkGvpkhtssllklikevkadh.gqythpliihcsaGvGrtGvvisid

SLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLRDASLCGITEIPSQEIASSLLVLRDN
| . ..    .|||. || ..| .| ..|||.|||||||.....  |   | ||   ..  |  |   
svvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhss
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 318-544 5.7e-73 240.7 In-house 48-284 (319) alignment 
Range on Protein: 318-544
Range on HMM: 48-284/319.0
PKRSDNFS-FVAVDTNRIRLSITNDIPCSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRDGCVRYGK
 |. . ..  .|.|  |. ||  .... |.|||||.||.|.| ...||||||.||||..||.||||...  .||||.|....... . |||.   ..||.
nkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGr

YIVTKIDEEELDDHTQRS---------MDSLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKIQSTEDHGPTVVHCSDGAGRTGVFLALAISIERLEAED
.|||  .||||.|   |          ...  | |||| .|. |..| .  .|. | ....| .. ...|| |||||.|.|||| |..| . .||.. | 
livtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeeg

TVDIFQTVRWLRSQRPALVGSIEQYSCCYQAVKSYLS
..|.|.||. || ||. .|   |||. .|.|.  ...
vlDvfstvsrlRtqRnimvqrpeqYkfiyealleave
0040438 (Phosphotyrosine protein) phosphatases II 324-546 1.1e-72 240.3 In-house 50-279 (317) alignment 
Range on Protein: 324-546
Range on HMM: 50-279/317.0
FSFVAVDTNRIRLSITNDIPCSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRDGCVRYGKYIVTKID
 ...  | .|..|| .. .. | ||||||.| .|. ...||||.|..||.. ||.|||||..| ||||||| ..|.. .. ||| .. . ||...|| ..
pdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtlls

EEELDDHTQRSM--------DSLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKIQStEDHGPTVVHCSDGAGRTGVFLALAISIERLEAEDTVDIFQTV
||||.. | | .        .|. |.||.|..|  || || .. |. . |.|.. .. ...||..||||.| ||||.|.|. . .|.|| | .||....|
eeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeav

RWLRSQRPALVGSIEQYSCCYQAVKSYLSWR
..||.|||  | . |||  .|.|.  || ..
kelreqRpgavqtpeqyrflydalleylkrk
0036941 (Phosphotyrosine protein) phosphatases II 322-546 6.5e-72 237.6 In-house 47-280 (297) alignment 
Range on Protein: 322-546
Range on HMM: 47-280/297.0
DnfsFVAVDTNRIRLsitNDiPCSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRD--GCVRYGKYIV
|   ... | .|..|   .| . | ||||||.| |.  ...||||.|..||...||.|||||..| ||||||| ..| .  . ||| .  . . ||...|
d...ilpydhtRVkl...dd.egsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftv

TKIDEEE--LDDHTQR--------SMDSLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKIQSTE-DHGPTVVHCSDGAGRTGVFLALAISIERLE---A
| ...|.  ||| |.|        . .|. |.||.|..|  ||.|. .. |. . |.|.|...   ..||..||||.| ||.|.|.|. . ...||    
tllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklk

EDTVDIFQTVRWLRSQRPALVGSIEQYSCCYQAVKSYLSWR
| .|||...|..||.|||  | . |||  .|.|.  .| ..
eggvdileavkklReqRpgavqtleqyrflyeallellkkk
0047943 (Phosphotyrosine protein) phosphatases II 314-543 1.7e-71 236.2 In-house 35-272 (273) alignment 
Range on Protein: 314-543
Range on HMM: 35-272/273.0
NMAAPKRSDNFSFVAVDTNRIRLsitnDIPCSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRDG---
  .  ..  . .....| .|..|    . . | ||||||.| ||  ...||||.|..||...||.|||||... |||||||...|..  . ||| .|   
lpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggel

CVRYGKYIVTKIDEEELDDHTQRSM--------DSLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKIQSTE-DHGPTVVHCSDGAGRTGVFLALAISIE
 ..|||..|| ..||. ||.|.| .        .|. |.||.|..|  || || .. |. . |.|.|....  ..||.|||||.| ||||.|.|| . ..
sltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllld

RLEAEDTVDIFQTVRWLRSQRPALVGSIEQYSCCYQAVKSYL
.||.| .||....|..||||||  | . |||  .|.|.  ||
qlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 16-254 7.1e-71 233.5 In-house 23-264 (274) alignment 
Range on Protein: 16-254
Range on HMM: 23-264/274.0
AQTPYNKTKNRYPNILPYDHSRVVLRAR-KDSHGSDYINANFVDGYGCPQK-YIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCERYWPED
 . . ..||||| .||| ..|||.|...  ... |.|||||.. ||.  .| |.|.||||..|..||||.|... .. |||| . . . .. |..|.|..
ldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPda

GHQ----EYGDVAVSVVDVTHMTDWTVRTFLVWvrlhpECMDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRY--HLSSEETGPILVHCGAGVGRTGT
 .     .|||| . |.....  |..||....      .. ..|.|. . .|.|||. .|... .|. . .. .   . ......|..||| ||.|||| 
edyeiserygdveikvekiverndysvrklvlk.....ylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGc

FIAIDSLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVL
||||.  . |.  |.|||| . |...| .|  ||||.||| .|. .|
fiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihral
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 325-544 1.1e-70 233.3 In-house 54-281 (318) alignment 
Range on Protein: 325-544
Range on HMM: 54-281/318.0
SFVAVDTNRIRLSITNDIPCSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRDGCVRYGKYIVTKIDE
  .| |. |..|. ... . |.||||.||| |.. ..|||.|||. .||..||.|||||... |||||....||..  . ||| .|   |||  |.  .|
nilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkee

EELDDHTQRSM--------DSLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKIQSTEDHGPTVVHCSDGAGRTGVFLALAISIERLEAEDTVDIFQTVR
 ||.|.. |..        .|  |  ..| .|. .|.|    .|. |  ||.|.| ....||.||||| | ||||||.|. | .||..|| .||.||||.
velsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvk

WLRSQRPALVGSIEQYSCCYQAVKSYLS
 ||.||...|   .||  .|.... .| 
qlreqrnlmvqtedqyefiydvlleala
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 19-267 1.8e-70 232.4 In-house 49-293 (297) alignment 
Range on Protein: 19-267
Range on HMM: 49-293/297.0
PYNKTKNRYPNILPYDHSRVVLRARKDSHGSDYINANFVDGYGCpqKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRsDCERYWPEDGHQEY
  |  |.|| |||||| ||| |. . |.  |||.|| || |.    ..|. | |  .|..|||......  .||||| | ... .  | |||...| ...
kvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttf

GDVAVSVVDVTHMTDWTVRTFLVWvrlHPECMDKREVTQFQFTAWPDQGVPE--NTAPLIIFHHKYRYHLSSEETGPILVHCGAGVGRTGTFIAIDSLMD
|||.| .  |.. .    |.. |    . .   .| | |.||. |||. |..  ... |. . .  | . |... ||.|||| ||||||| ...||| . 
GdvsvvllsvsereGfikrelevt...kgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvva

QMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLRDASLCGITEIPS
..  |  ||..|.| ..| .| ..|||.|||.|.| .. .| |.  |.|..
eakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqa
0043336 (Phosphotyrosine protein) phosphatases II 323-542 4e-70 231.8 In-house 51-276 (278) alignment 
Range on Protein: 323-542
Range on HMM: 51-276/278.0
NFSFVAVDTNRIRLSITNDIPCSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPrDGCVRYGKYIVTKI
  .... | .|..|| ..  . | ||||||.| ||  ...||||.|...|.. ||.||||...| ||||||| ..|.. .  ||| .| ..||.. || .
ykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtll

DEEELDDHTQRSM--------DSLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKIQStEDHGPTVVHCSDGAGRTGVFLALAISIERLEAEDTVDIFQT
.||.||| |.| .         |. |.|..|..|  || |. .. |. . ..|.....  ..||..||||.| ||||.|.|| . .|.|| | .||....
keehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleea

VRWLRSQRPALVGSIEQYSCCYQAVKSY
|..||.|||  | . .||  .|.|.. |
vkelreqRpgavqtpsqyrflyealley
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 8-283 6.6e-70 230.8 In-house 36-313 (325) alignment 
Range on Protein: 8-283
Range on HMM: 36-313/325.0
GPRAtFEAAQTPYNKTKNRYPNILPYDHSRVVLRARKDSHGSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLI--WEkgCTTIVMLGDTEHKlRSD
.. | ...|  | || |||..|....|.||||| ..||.  ||||||...  .   . ..||| |||.||.|.|||.  |.  |. .|.|   ...    
dgia.kkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr..csvvvvlneldlg.kdr

CERYWPED--GHQEYGDVAVSVVDVTHMTDWTVRTFLVWvrlHPECMDKREVTQFQFTAWPDQGVPENTAPLIIFHHKY-----RYHLSSEETGPILVHC
|  |||..    ...| . |... . ...|.  | . |     ..  . | | |||. .|.| ||..  | || . .       | .  .. ..||||||
cavywpkemgksktfGglevklrtieeisdyvhrvldvk...qvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhc

GAGVGRTGTFIAIDSLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLRDASLCGITEIPSQEIASSLLVLRDNDPD
 |||||||.||.. |...... |  ||..||| ..| .|  ||.| .|| .||. | .| ..| |..|   . . |  |.. .| 
saGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklsslqernpl
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 18-261 1.9e-69 228.8 In-house 44-281 (287) alignment 
Range on Protein: 18-261
Range on HMM: 44-281/287.0
TPYNKTKNRYPNILPYDHSRVVLRarkdSHGSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCERYWPEDGHQE
.. || |||. .||..|  ||.|.     .  ||||| |.|||   ...|.|..|...|...||.||...  |.|||| . . . .. | .||||.    
asqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvv

YGDVAVSVVDVTHMTDWTVRTFLVwvRLHPECMDKREVTQFQFTAWPDQG-VPENTAPLIIFHHKYRYHLSSEEtGPILVHCGAGVGRTGTFIAIDSLMD
.|. ...... ........|.. |  . . .  ||..|.|.|.|.|...| |.|  . |......|. .  . . ..|.||| ..|||...|.|..  ..
lGeyniellneevnagyierklev..knknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgn.tsivvhCsdtvGrsamfcaaattin

QMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLRDASLCG
.   |||.||.  . ..| |.  .||| ||| ||.|..     ..
kckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsf
0039614 (Phosphotyrosine protein) phosphatases II 323-545 3.3e-69 228.9 In-house 62-291 (297) alignment 
Range on Protein: 323-545
Range on HMM: 62-291/297.0
NFSFVAVDTNRIRLSITNDI-PCSEYINASYIDSYNE-AHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQiESELYWPRDGCvRYGKYIVT
  .... | .|..|.  ..  . | ||||||.| |.   ...||||.|...|.. ||.|||||..|.|||||.| ..|.   . ||| .|  .||.. ||
ykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvt

KIDEEELDDHTQRSM------DSLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKIQSTE-DHGPTVVHCSDGAGRTGVFLALAISIERLEAEDTVDIFQ
 ...|.||. |.| .       |. |.||||..|  || || .. |  . |.|......  ..||..||||.| ||||.|.|. . .|.|| | .||...
llkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvle

TVRWLRSQRPALVGSIEQYSCCYQAVKSYLSW
.|..||.|||  | . .||  .|.|.. .|..
avkelreqRpgavqtpsqyrflydallellkr
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 2-254 9.9e-68 223.1 In-house 27-279 (290) alignment 
Range on Protein: 2-254
Range on HMM: 27-279/290.0
QSLSHLGPRATFEAAQTPYNKTKNRYPNILPYDHSRVVLRARKDSH--GSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTE
..|       | . . |. ||..||. ||..||  |..||   . .    .|||| ...||   ..|||.|||...|..|||.|||.. .| |||| .  
kmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltnii

HKLRSDCERYWPEDGHQEYGDVAVSVVDVTHMTDWTVRTFLVWVRLHPecMDKREVTQFQFTAWPDQG-VPENTAPLIIFHHKYRYHLSSEeTGPILVHC
 . .  |  |||. . ..|| . . ... ..... . |.. |  .      .|..|||.|.|.|...| |..... |..... |. .  .   ..|.|||
eegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsa..gakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrg.ntsivvHC

GAGVGRTGTFIAIDSLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVL
 ..|||...|.|..  .... .|||.||.  . ..|.|.  .||| .|| .|....
SdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqiv
0045450 (Phosphotyrosine protein) phosphatases II 284-543 1.6e-67 223.8 In-house 25-304 (307) alignment 
Range on Protein: 284-543
Range on HMM: 25-304/307.0
IIRQRQDEFEVSLACVASVsvfSRNRERTRNMAAPKRSDNFSFVAVDTNRIRLSITNDI-PCSEYINASYI--------DSYNEAHEYIATQAPMENTIN
..   . |||  | .   .   . ... ..  .  ..    .... | .|..|| ...  . | ||||||.        |.|.  ...||||.|...|..
fltgllkefekllsvtvfl...lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetve

EFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRDGCV-RYGKYIVTKIDEEELDDHTQRSMDSL---------LVYHFQYHNWSAHGMPPRMNGLVFLH
.||.|.|||..|.||||||| ..|..    ||| .| .  ||.. || ..||.||. | | .             |.||.|..|  || || .. |. . 
dFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfi

EQVQKIQSTE-DHGPTVVHCSDGAGRTGVFLALAISIERLEAEDT---VDIFQTVRWLRSQRPALVGSIEQYSCCYQAVKSYL
|.|.|....  ..||..||||.| ||||.|.|. . ...||.| |   ||....|..||.|||  | . |||  .|.|.. .|
eevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
DSPc_SM00195 325-543 3.2e-67 222.0 In-house 34-262 (263) alignment 
Range on Protein: 325-543
Range on HMM: 34-262/263.0
SFVAVDTNRIRLSITNDIPCSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRD--GCVRYGKYIVTKI
 .. .| .|..|. ... . |.||||.||. .|. ..|||||.|...|...||.||||.|.. |||||| ...|... . |||..  |  ..||. |. .
nilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklv

DEEELD-DHTQRSM--------DSLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKIQSTEdHGPTVVHCSDGAGRTGVFLALAISIERLEAEDTVDIFQ
..|. . . ..| .        ..  |...||.||  ||.|  .. .. | ..|.| .||. .||.|||||.| ||||.|... | ...||.|..||||.
evekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdife

TVRWLRSQRPALVGSIEQYSCCYQAVKSYL
.|. ||.||| .| . |||. .|.|.  |.
ivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 325-543 3.2e-67 222.0 In-house 34-262 (263) alignment 
Range on Protein: 325-543
Range on HMM: 34-262/263.0
SFVAVDTNRIRLSITNDIPCSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRD--GCVRYGKYIVTKI
 .. .| .|..|. ... . |.||||.||. .|. ..|||||.|...|...||.||||.|.. |||||| ...|... . |||..  |  ..||. |. .
nilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklv

DEEELD-DHTQRSM--------DSLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKIQSTEdHGPTVVHCSDGAGRTGVFLALAISIERLEAEDTVDIFQ
..|. . . ..| .        ..  |...||.||  ||.|  .. .. | ..|.| .||. .||.|||||.| ||||.|... | ...||.|..||||.
evekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdife

TVRWLRSQRPALVGSIEQYSCCYQAVKSYL
.|. ||.||| .| . |||. .|.|.  |.
ivkelRkqRpgmvqtleqYlfiyeaileyi
0040439 (Phosphotyrosine protein) phosphatases II 325-543 4e-67 221.7 In-house 19-246 (249) alignment 
Range on Protein: 325-543
Range on HMM: 19-246/249.0
SFVAVDTNRIRLSITNDIPCSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRDGCVRYGKYIVTKIDE
.... | .|..|||... ..| |||||||| |.  ...||||.|...|.. ||.|.||...|.|||||.|. .|..  . ||| .| . ||.. || ...
dilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsv

EELDDHTQ--------RSMDSLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKIQSTE-DHGPTVVHCSDGAGRTGVFLALAISIERLEAEDTVDIFQTV
|..|| |.           .|. |.|.||..|  || || .. |. . |.|.|....  ..||..||||.| ||||.|.|. . .|.|| | .||....|
evkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeav

RWLRSQRPALVGSIEQYSCCYQAVKSYL
..||||||  | . |||  .|.|.. .|
kllrsqRpgavqnpeqyrflyeallell
subfamily_PTPRA_pd Subfamily PTPRA 287-543 1e-66 220.1 In-house 33-295 (330) alignment 
Range on Protein: 287-543
Range on HMM: 33-295/330.0
QRQDEFEVSLACVASVSVFSRNRERtrNMaapKRSDNFSFVAVDTNRIRLSITNDIPCSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCT
. ..||.   |.    ..   ..|   |.   ...     .  | .|. ||  . ...|.|||||.|| |.| ...||.| | |.|...||.|.|||| .
lfreefnalPagpiqatlelaskee..nk...eknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksa

AIVMLTELQDRGQIESELYWPRDGCVRYGKYIVTKIDEEELDDHTQRSM------------DSLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKIQSTE
.|||||||..| .   . ||| .|.| ||.  |.  ||..| | | | .            .| ||  | .. |   |.|    |.. | ..|.|..  .
tivmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqs

DHgPTVVHCSDGAGRTGVFLALAISIERLEAEDTVDIFQTVRWLRSQRPALVGSIEQYSCCYQAVKSYL
   | ||||| |.|||| |..|   .||..||  ||.|..|. || ||| .| . |||  .|.... | 
ag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy
Y_phosphatase Protein-tyrosine phosphatase 326-539 2e-66 219.1 Pfam-A 10-233 (235) alignment 
Range on Protein: 326-539
Range on HMM: 10-233/235.0
FVAVDTNRIRLsiTNDIPCSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWP--RDGCVRYGKYIVTKI-
... | .|..|  ...   |.||||.|...|.| ...||||.|...||..||.|||..|...|||||.|...|. . . |||  ... ..||.. |.   
ilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelke

DEE-ELDDHTQRSM---------DSLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKIQsTEDHGPTVVHCSDGAGRTGVFLALAISIERLEAEDTVDIF
.|. . .. | | .         ..  |....|.||  ||.|   ..|. | ..|.| . ....||.|||||.|.||||.|.|| | .|.||||..||..
kekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvl

QTVRWLRSQRPALVGSIEQYSCCYQAV
|.|. ||.||| .| |.|||  .|.|.
qivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 326-539 2e-66 219.1 In-house 10-233 (235) alignment 
Range on Protein: 326-539
Range on HMM: 10-233/235.0
FVAVDTNRIRLsiTNDIPCSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWP--RDGCVRYGKYIVTKI-
... | .|..|  ...   |.||||.|...|.| ...||||.|...||..||.|||..|...|||||.|...|. . . |||  ... ..||.. |.   
ilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelke

DEE-ELDDHTQRSM---------DSLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKIQsTEDHGPTVVHCSDGAGRTGVFLALAISIERLEAEDTVDIF
.|. . .. | | .         ..  |....|.||  ||.|   ..|. | ..|.| . ....||.|||||.|.||||.|.|| | .|.||||..||..
kekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvl

QTVRWLRSQRPALVGSIEQYSCCYQAV
|.|. ||.||| .| |.|||  .|.|.
qivkelRkqRpgmvqsleqYiflykai
subfamily_CG7180_pd Subfamily CG7180 20-262 2.2e-66 218.5 In-house 41-294 (296) alignment 
Range on Protein: 20-262
Range on HMM: 41-294/296.0
YNKTKNRYPNILPYDHSRVVLRARKDSHGSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRsDCERYWPEDGHQEYG
 |. |||.....|||. ||||.  .  . |||||| .||..  ...||  ..| .||...||||...... ..|.| .|    .  .  |||......||
enreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqyg

DVAVSVVDVTHMTDWTVRTFLVWVR-------LHPECMDKREVTQFQFTAWPD-QGVPENTAPLIIFHHKYRYHLSSE----ETGPILVHCGAGVGRTGT
.. | .| . .... . ||| .  .        ... ...| |..||.| |.  . ||  |. || . .. |          |.||..|..  |..|.| 
eifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGv

FIAIDSLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLRDASLCGI
..|||  ....  |. |||...| ..| .|. .|.. |.| .||||| .| ||. 
ylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 20-253 3.8e-66 217.7 In-house 2-234 (237) alignment 
Range on Protein: 20-253
Range on HMM: 2-234/237.0
YNKTKNRYPNILPYDHSRVVLRARKDShgSDYINANFVDGY-GCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCERYWPE-DGHQE
 || |||| ||  ||||||||.    .  ||||||....|. | |.|||||||||  . .|||...|.. |. ||||     . .  | .|||. |  . 
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGDVAVSVVDVTHMTDWTVRTFLVWVRLHPEcmDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRYHLSS-EETGPILVHCGAGVGRTGTFIAIDSLMD
|| ..||.    ...|.|||..|. .||. .  . | . |.|||.|||.|||..|| |. | ..   .     |.|| ..|| ||||||| |. ||... 
ygvltvslkkkeefsdytvrslllskrltlk..evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlr

QMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDV
|   . |||.| .|  .  .| ...||..|| ||...
qakekkvvdiynyvysieedrpyiiqtkdqyvfihqt
0042113 (Phosphotyrosine protein) phosphatases II 324-543 3.4e-65 215.2 In-house 16-243 (245) alignment 
Range on Protein: 324-543
Range on HMM: 16-243/245.0
FSFVAVDTNRIRLSITNDIPCSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRDGCVRYGKYIVTKID
 .... | .|..|| ..  . | ||||||.| |.  . .||||.|...|.. ||.|.||...|.||||||. ..|.. .. ||| .. ..||...|| ..
sdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtlls

EEELDDHTQ--------RSMDSLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKIQSTEDHGPTVVHCSDGAGRTGVFLALAISIERLEAEDTVDIFQTV
|| ||| |.        ..  |. |.|..|..|  ||.|. .. |. ..| |.|...  ..||..||||.| ||||.|.|. . .|.||.| .|.....|
eehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeav

RWLRSQRPALVGSIEQYSCCYQAVKSYL
..||||||  | . .||  .|.|.. .|
kelrsqRpgavqtpsqyrflyeallell
subfamily_Ptp69D_pd Subfamily Ptp69D 268-545 3.7e-65 215.1 In-house 7-288 (307) alignment 
Range on Protein: 268-545
Range on HMM: 7-288/307.0
QEIASSLlVLRDNDPDIIRQRqdEFEVSLACvaSVSVFSRNRERTRNMAApKRSDNfsFVAVDTNRIRLSITNDIPCSEYINASYIDSYNEAHEYIATQA
......| . |..|.|   ..  |.|   |    ..  ... |.  |     |...   .| | .|..|. .|    |.|||||.| .|.| ...|| |.
ddleeal.ksrkrdtdfglak..eyekLear..eidkstkvsekkenalk.nRyed..ikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqd

PMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRDGCVRYGKYIVTKIDEEELDDHTQRSM-------------DSLLVYHFQYHNWSAHGMP
|.|.||..||.|..||. | ||||..|..  . . . ||| .  |.||. .|. ..||. .|...|..             ||  |  ..| .|    .|
PveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvP

PRMNGLVFLHEQVQKIQSTEdHGPTVVHCSDGAGRTGVFLALAISIERLEAEDTVDIFQTVRWLRSQRPALVGSIEQYSCCYQAVKSYLSW
   .||. | |||....... ..| ||||| |.||.|.|.||.. ...|.|||.||||.||. |||||. || |.|||. .|.|.  | |.
evargllklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssy
subfamily_PTPN3_pd Subfamily PTPN3 4-254 4.3e-65 214.4 In-house 24-271 (280) alignment 
Range on Protein: 4-254
Range on HMM: 24-271/280.0
LSHLGPRATFEAAQTPYNKTKNRYPNILPYDHSRVVLRARKdshGsDYINANFVD----GYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTE
|    |  . .||. | | .|||| .|||||. || |.. .     ||||||.|.    . |  ..|||.||||..| .|||...||. ...|||| .. 
lyrkkpglaisaarkpenlsknryrdilpydatrvklkese...t.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlv

HKLRSDCERYWPEDG-HQEYGDVAVSVVDVTHMTDWTVRTFLVWVRlhpECMDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRYHLSsEETGPILVHC
 . |  | .|||| . ..|||.  | .    . . . .| ...  .   |  ..|...|.|..||||.|||...| .. | .. |   |  .. |..|||
erGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdk...etkeerkilqlqylaWpdhgvPddsadflefvervrklrs.gkeePvvvhC

GAGVGRTGTFIAIDSLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVL
 ||.|||| .|...  .  . ..  | .   | .|| ||  .|||..|| |. . .
saGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeai
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 307-544 5.4e-64 211.3 In-house 46-291 (298) alignment 
Range on Protein: 307-544
Range on HMM: 46-291/298.0
RNRERTRNMAAPKRSDNFSFVAVDTNRIRLSITNDIPCSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYW
 . | .|. .  |.    . .|.|  |..|. ...   |.|||||....|.. . .||||||...|...||.||.|.. ..|||||.|.. .... . ||
eekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkyw

PRDGCVRYGKYIVTKIDEEELDDHTQRSM--------DSLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKIQSTEDHGPTVVHCSDGAGRTGVFLALAI
| .|  .||.  |.   .||  | ..| .        ..  | .... .|. .|.|  .. .. | ..|.. |.   . | .|.||.| ||.| | |.  
PdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaids

SIERLEAEDTVDIFQTVRWLRSQRPALVGSIEQYSCCYQAVKSYLS
 .||...| .||.||.|. || .||..| . |||. .|.||  .|.
vlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald
subfamily_PTPN13_pd Subfamily PTPN13 1-254 7.3e-64 210.7 In-house 17-265 (273) alignment 
Range on Protein: 1-254
Range on HMM: 17-265/273.0
FQSLSHLGPRATFEAAQTPYNKTKNRYPNILPYDHSRVVLRARKDshgsdYINANFVDGYGCP--QKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDT
|. | .| |  | | ...  ||.|||| |.||||..|| | .        ||||...         .|||.|||| ||.||||...||. .. |.|.   
fkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtle

EHKLRSDCERYWPEDGHQE---YGDVAVSVVDVTHMTDWTVRTFLVwvrLHPECMDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRyHLSSeETGPIL
  | .  |.|||||  ...   .. . |....|... ...||.. |    . |  . |||....|..||| ||| ..|.|. |  . | .| . ..|||.
kekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralav...kdsesgesrevahlnfvkwPdhgvPssaaellqfvaevr.rlqt.dagPiv

VHCGAGVGRTGTFIAIDSLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVL
||| ||.||.||.|.|| ... .  .  .||   | ..| ||. .|||..|| |.| ..
vhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykai
subfamily_PTPRB_pd Subfamily PTPRB 325-545 1.9e-63 209.3 In-house 59-287 (293) alignment 
Range on Protein: 325-545
Range on HMM: 59-287/293.0
SFVAVDTNRIRLSITNDIPCSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRD-GCVRYGKYIVTKID
  .. |..|..|. ..| . |.||||.||. ||  .|.|||| |. .|...||.||||.|...|||||.| ..|..  | |||.|   | ||.  || . 
nilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlva

EEELDDHTQRSM------DSLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQK-IQSTEDHGPTVVHCSDGAGRTGVFLALAISIERLEAEDTVDIFQTVR
||||.|.. |..      ..  | ....  |. ||.| . . |. . ..|.. |..|....|.||||| | ||||.|.||   ....| ||.|||| .| 
eeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgiva

WLRSQRPALVGSIEQYSCCYQAVKSYLSW
 ||..|  || . .|| . .|.| ..|. 
elReeRnllvqtekqYifihqcvldllrk
0045098 (Phosphotyrosine protein) phosphatases II 325-546 3e-63 209.1 In-house 41-275 (278) alignment 
Range on Protein: 325-546
Range on HMM: 41-275/278.0
SFVAVDTNRIRlsitndipcsEYINASYIDSYneAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRDGCVRYGKYIVTKIDE
.....| .|..          .||||||||.|   ...||||.|...|.. ||.|.||...|.|||||||...|..  . ||| .|...||.. || ..|
dilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllse

EELDDHTQ------------RSMDSLLVYHFQYHNWSAHGMPPRM--NGLVFLHEQVQKIQS------------TEDHGPTVVHCSDGAGRTGVFLALAI
|.||| |              .  |. |.|..|..|  || |.    . .  | |.... ..             ...||..|||| | ||||.. |. .
evlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaayl

SIERLeaEDTVDIFQTVRWLRSQRPA-LVGSIEQYSCCYQAVKSYLSWR
 .|.|  |..||....|..||||||   | . |||  .|...  .|...
mlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 322-541 3.5e-63 208.3 In-house 52-277 (288) alignment 
Range on Protein: 322-541
Range on HMM: 52-277/288.0
DNFSFVAVDTNRIRLSITNDIPCSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRDGC-VRYGKYIVT
     ...| .|..|   .. . ..||||||||.... ..|||||.|. .|.|.||..|.|.| . ||||||| ..|. . | ||| ..  ..||.  ||
RyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvt

KIDEEELDDHTQRS------MDSLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQkIQSTEDHGPTVVHCSDGAGRTGVFLALAISIERLEAEDTVDIFQT
 ....||.|...|.      .. | . ..||  |. ||.|   . |. | .||. .....| || .||||.| ||||.|.||   |...|.||..|.. |
lveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvk.vanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagt

VRWLRSQRPALVGSIEQYSCCYQAVKS
|  || ||. ||   .||  .|... |
vaklRkqRallvqtlkqYefiyevlls
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 315-543 3.8e-63 208.4 In-house 44-283 (305) alignment 
Range on Protein: 315-543
Range on HMM: 44-283/305.0
MAAPKRSDNFSFVAVDTNRIRLSITNDIPCSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRDGCV--
 |  ... . . .  |..||.|. ... . |.||||||.|.|.. ..||..|.|..||...||....| | . |||||.|.. |.   . |||       
eankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekk

RYGKYIVTKIDEEELDDHTQRSM---------DSLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKIQSTEDHGPTVVHCSDGAGRTGVFLALAISIERL
..|...|.  .|..  |...| .         .|  | ..|  .|  ||.|     |. | ..||| |. .   | .||||.| ||||||.|. | .|||
efgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerl

EAEDTVDIFQTVRWLRSQRPALVGSIEQYSCCYQAVKSYL
..|..||.|. .. |||.|. .| . .||  ...|.. ..
kkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldeli
subfamily_PTPRK_pd Subfamily PTPRK 322-539 6.7e-63 207.4 In-house 48-273 (314) alignment 
Range on Protein: 322-539
Range on HMM: 48-273/314.0
DNFSFVAVDTNRIRLSITNDIPCSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRDGCVrYGKYIVTK
     .| |  |..|  ... | |.||||..||||. ....|.|| |...|...||..|....|..|||||||.. |...   ||| |. | ||.  |. 
rsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.ygdikvel

IDEEELDDHTQRS----------MDSLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKIQSTeDHGPTVVHCSDGAGRTGVFLALAISIERLEAEDTVDI
.. | | .  .|            .  .| .||. .|..|..|   .||. |  .|.| |   ..|..||||| ||||||.|.|..| .. .| |..||.
vetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmieregvvdv

FQTVRWLRSQRPALVGSIEQYSCCYQAV
|..|. |||... .|   |||  .|...
fnavktlrsrkvnmveteeqykfiydvi
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 21-254 8.3e-63 206.9 In-house 20-260 (270) alignment 
Range on Protein: 21-254
Range on HMM: 20-260/270.0
NKTKNRYPNILPYDHSRVVLRARKDSHGSDYINANFVDGY-GCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCERYWPEDGHQeYG
.|. ||| .|||  ..||.|   .. . . |||||.| |. | ..|||||.|||  |.|.|||.|||.  |.|||. . | | |. ||||||.. ..   
gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepke.kv

DVAVSVVDVTHMTDWTVRTFLV-WVRLHpECMDKREVTQFQFTAWPDQGVPENTA------PLIIFHHKYRYHLSSEET-GPILVHCGAGVGRTGTFIAI
...   . |. ...   . ...  .||. |  ..|... |....|||.|||...        |.   .. | . .. .  .|.|||| ||||||||.||.
kledgkikvlalseekeegyiltrlrle.ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlial

DSLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVL
|  .  . ... |||   ....| .|  .||. |||.|.| ..
DiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykav
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 17-256 1.1e-62 207.0 In-house 44-277 (439) alignment 
Range on Protein: 17-256
Range on HMM: 44-277/439.0
QTPYNKTKNRYPNILPYDHSRVVLRARKDSHGSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRsdcerYWPEDGHQ
   |..||||| .. ..||.||.|.       | |||||...||  .. |||.|||  || .|||||..|| ..||||| .  .  .     ||| |.. 
aqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaev

EYGDVAVSVVDVTHMTDWTVRTFLVWVRLHpECMDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRYHLSSEETGPILVHCGAGVGRTGTFIAIDSLMD
 |||.|| |     . ....| | |. .    .  .| | ||...||||. || ... .. | .       .||.||..||| |||||||| ||.|  ..
cygdiavrvdrnielpnyvirgfkvfnerd.ttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdiale

QMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLRD
|. .|  ||. | |  .| ||. |||.  || |||. . .
qlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle
subfamily_PTPRG_pd Subfamily PTPRG 317-544 1.1e-60 200.4 In-house 47-288 (563) alignment 
Range on Protein: 317-544
Range on HMM: 47-288/563.0
APKRSDNFSFVAVDTNRIRLSITNDIPCS-EYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRDGCVRYG
  ..  . . ||.|  |..|| . ..  . .||||.||| |. ....|||| |...|.. ||.|.|||. . |||.|.|..||. . . |||.|. ..||
nkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetyg

KYIVTKIDEEELDDHTQRSM--------------DSLLVYHFQYHNWSAHGMPPRM-NGLVFLHEQvqKIQSTEDHGPTVVHCSDGAGRTGVFLALAISI
.  || |.|| |   |.|..              . .||....| .|  || |      | | . .  .    .. ||.||||| |.||||....|   .
alqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks..saankaeaGPivvHcsaGvgrtGtyivldtll

ERLEAEDTVDIFQTVRWLRSQRPALVGSIEQYSCCYQAVKSYLS
.....|..|..|.... .|.||. || ..|||   ..|. . ..
kqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaia
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 320-545 1.9e-60 199.2 In-house 12-244 (250) alignment 
Range on Protein: 320-545
Range on HMM: 12-244/250.0
RSDNFSFVAVDTNRIRLSITNDIPCSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIeSELYWPRDGCVRYGKYIV
.     ..|.|  |. |  ..    |.|||||....|.| . .||||.|...||..||.||.|.| ..|||||.|.. ..   . ||| ..  .||.  |
knryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaekyGdvtv

TKIDEEELDDHTQRSM--------DSLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKIQSTEDHGPTVVHCSDGAGRTGVFLALAISIERLEAEDTVDI
.  ..||  | |.| .        |. .| .... .|   |.|  ..  . | ..||. |   . .| .|.|| | ||.| |.|.   .|||. | .||.
sllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdv

FQTVRWLRSQRPALVGSIEQYSCCYQAVKSYLSW
|. .. || .||  | | |||. .|.... .|  
fkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 10-254 2.4e-60 198.8 In-house 27-273 (287) alignment 
Range on Protein: 10-254
Range on HMM: 27-273/287.0
RATFEAAQTPYNKTKNRYPNILPYDHSRVVLRArKDSHGSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCERY
 ||| ||.  ..  |||| ..||.|..||.| | .  .||||||||.| .|   ...||||||.. |..||||...|.  ......     . |  | .|
tatfkaaeelaavkknryadvlPiddtrvllsa.egelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcyky

WPEDgHQ--EYGDVAVSVVDVTHM-TDWTVRTFLVwvrLHPECMDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRYHL----SSEETGPILVHCGAGV
|||  ..    |  .| ..| . .  ...||.. .   .. |  . | | |... .|||....  .  || |  . . |.    ...|.||..||. .|.
wPer.evPmrvGGysvvlldydikePeygvralrl...idletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGi

GRTGTFIAIDSLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVL
||.|...|.  |....   | |||   |...| .|. .||.  |. ..|. |
GrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyeal
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 15-270 6e-60 197.5 In-house 27-278 (283) alignment 
Range on Protein: 15-270
Range on HMM: 27-278/283.0
AAQTPYNKTKNRYPNILPYDHSRVVLRARKDshgsDYINANFVD---GYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCERYWP
 | .  ||.|||. .|.|.|  || |..       ||||| |.     |   .|||.||.|| .|..|||......  |.||||      ||  | .|||
iasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWP

EDGHQEYGDVAVSVVDVTHMTDWTVRTFLVWVRlhPECMDKREVTQFQFTAWPDQGVPENTAPLIIFhHKYRYHLSSEETGPILVHCGAGVGRTGTFIAI
..| ..||. .|.. . |    .... .|. |     . ..  .. .|.  | . |       |. |  | .     .. |||.||| .|.|||..|||.
krGsedyGeftvtlrkettsnsfiikelllrvn..ssakstlllahyqvidWleygeqaiinslvkf.nkvislqteskkgPivvhCstgiGrtavfiaa

DSLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLRDASLCGITEIPSQEI
 . ..... | ||||.  |  || ||  .||| .|| .....  . .||| |.|   ..
sasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdl
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 309-544 1e-59 196.8 In-house 40-284 (290) alignment 
Range on Protein: 309-544
Range on HMM: 40-284/290.0
RERTRNMAAPKRSDNfsFVAVDTNRIRLS-ITNDIPCS-EYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYW
.. | .    .|..|  .|  | ||| |  |...  |. |||||.||. |.|...|||||.|..||. .||...|..|.|.|||||. .. |. .   ||
vgltssnkllnRfan..ivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYW

PRDGCVRYGKYIVTKIDEEELDDHTQRSMD---------SLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKIQSTEDHGPTVVHCSDGAGRTGVFLALA
|  .  .||.. .. ..||.|.. ..| ..         .  | ..|  ||  .|  .  .. . . |...|.|  .  .. ||||||. ||..||.|.|
pdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaa

ISIERLEAEDTVDIFQTVRWLRSQRPALVGSIEQYSCCYQAVKSYLS
..|.. . |  .|.|| .. .|.|.| .| . .||   .| | .||.
ttinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld
subfamily_PTPRN_pd Subfamily PTPRN 12-253 7e-59 193.9 In-house 47-287 (297) alignment 
Range on Protein: 12-253
Range on HMM: 47-287/297.0
TFEAAQTPYNKTKNRYPNILPYDHSRVVLRARKDSHGSDYINANFVDG-YGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCERYW
| |.|... | .|||. ..|||||||| |... ... |||||| ..         |||.||||..|. |||...||.|.. ||.|   |..  . |.|||
tkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckryw

PEDGHQEYGDVAVSVVD-VTHMTDWTVRTFLVWvRLhpECMDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRYHLSSeETGPILVHCGAGVGRTGTFI
|..|.. |.   | .|       |. ||.| .   |  .  . | |||| | .||..||| .. .|. |  |         . ||.||| .|.||||..|
pdeGsevyhiyevhlvsehiwcddylvrsfylk.nl..qtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG.rscpivvhcsdGaGrtGvyi

AIDSLMDQMMmEGV--VDVYGFVAQMRTQRNFMVQTHEQYAFIYDV
.|| ......  ||  .|.   .  .| ||. .|.|..|. |.. .
lidlvlnrll.kGvkeidiaatlehlrdqrpglvktkdqfefalta
0037934 (Phosphotyrosine protein) phosphatases II 322-542 9.7e-59 194.2 In-house 15-241 (243) alignment 
Range on Protein: 322-542
Range on HMM: 15-241/243.0
DNFSFVAVDTNRIRLsitNDipcSEYINASYIDSYNeahEYIATQAPMENTINE----FWQMVWEQKCTAIVMLTELQDRGQIESELYWPrDGCvRYGKY
   .... | .|..|   ..   | ||||..|. ..    .||||.|...|...    ||.|.||...|.|||||||...|..  . ||| ..  .||..
rysdilpydhsrvkl...eg...sdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.gev.tygdf

IVTKIDEEELDDHTQR---------SMDSLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKIQST-------EDHGPTVVHCSDGAGRTGVFLALAISIE
.|| ..||.||| |.|         .  ..||.|..|..|  ||.|. .. |. ....|.....         ..||..|||| | ||||...|. . ..
tvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmll

RLeaedTVDIFQTVRWLRSQRPA-LVGSIEQYSCCYQAVKSY
.|    .||....|..||.|||   | . .||  .|.|.. .
ll....gvdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 14-278 1.4e-58 193.2 In-house 38-256 (392) alignment 
Range on Protein: 14-278
Range on HMM: 38-256/392.0
EAAQTPYNKTKNRYPNILPYDHSRVVLRARKDSHGSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEH-Klrsdcerywpe
 .||.. |. |||| |||||| .||.|    |.  |||.|| ..... . . |||.||| . ...||||.....  |||.|. . .              
tvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...........

dghqeygdvavsvvdvthmtdwtvrtflvwvrlhpECMDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRYHLSSeETGPILVHCGAGVGRTGTFIAID
                                      |.| |.||.|| |||..||. |. |. | .. . .  .  | |...|| |||||||  |.||
...................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGq.ythpliihcsagvgrtgvvisid

SLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLRDASLCGITEIPSQEIASSLLVLR
|.. .     .|||. ||...| .| .||||.|||||||  . .  |   | ||   ..  |  | 
svvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdls
subfamily_PTPN23_pd Subfamily PTPN23 19-254 5e-57 187.9 In-house 41-277 (288) alignment 
Range on Protein: 19-254
Range on HMM: 41-277/288.0
PYNKTKNRYPNILPYDHSRVVLRARKDshgsDYINANFVDGY--GCPQkYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCERYWPEDG--
  . .|||. .||||||.||.||  ||    ||||| || .   |||. .||.|.|| .|. |||....|.   .|||| . | . .  ..||||||   
klyseknrsrdilPyDhnRvklrgskD....DYinAsfvkdlspgcPd.fiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkge

HQEYGDVAVSVVDVTHMTDWTVRTFLVWVRlhpECMDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRYHL--S-SEETGPILVHCGAGVGRTGTFIAI
 ...||. |.. .|...  .  |.. . ..   .   ...|.  |.|.||. |||.    |. | .. . ..     .   |..||| |||||||.|  .
tvkfgdlsvtlksvretethvervlkletl...dadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalv

DSLMDQM-MMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDV-L
 . . ..   .|..|.   | ..|.|| ||||..||. | |.. |
yaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavl
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 319-541 6.7e-57 187.8 In-house 51-278 (315) alignment 
Range on Protein: 319-541
Range on HMM: 51-278/315.0
KRSDNFSFVAVDTNRIRLSITNDIPCSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRDgCVRYGKYI
..   .  .| |  |..| ...  | |.|.||..|| ||  . |||.|.|  .....||..|.|.... |||||.| .. .  .| ||| .  | |||. 
qknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkit

VTKIDEEELDDHTQRSMDSL------LVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKIQsTEDHGPTVVHCSDGAGRTGVFLALAISIERLEAEDTVDIF
||...||  .. | |..          |. ..|  |   |.|     |. |. .|.. . |.. |. |||||.| |||| |..|   ....|||. .|..
vtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhh.tnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvy

QTVRWLRSQRPALVGSIEQYSCCYQAV-KS
. .. .|..|  .| ..|||   |.|. ..
nfitgvrqnrikmvqvaeqyqfiydallet
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 326-547 1e-56 187.1 In-house 53-281 (315) alignment 
Range on Protein: 326-547
Range on HMM: 53-281/315.0
FVAVDTNRIRLSITNDIPCSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPR--DGCVRYGKYIVTKID
 . .|..|..| . .|.| |.||||||| |... . |||.|.| . ....||.||...| |.|||.|..|.  .|.   |||      |..|.. |. ..
ilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvells

EEELDDHTQRSM------DSLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKIQSTEDHgPTVVHCSDGAGRTGVFLALAISIERLEAEDTVDIFQTVRW
 |   | ..| .      .|  |  ||...|  .| . ..  |. |  .|.  . .... . .|||| |.|||||....   ..... ...||.|..|. 
leadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkef.sllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvkn

LRSQRPALVGSIEQYSCCYQAVKSYLSWRT
||..|| || . |.|.  |.||. .| || 
lrakrpylvqteeeyafiydavledllwrn
subfamily_PTPN14_pd Subfamily PTPN14 10-254 1.1e-56 187.0 In-house 38-292 (300) alignment 
Range on Protein: 10-254
Range on HMM: 38-292/300.0
RATFEAAQTPYNKTKNRYPNILPYDHSRVVLRARKDShGSDYINANFVDGY--GCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCE
 |....|. | |. |||....|||...|| | . |..  ..||||  .     |  ..||.|||||  |..|||...||.| . |||| ..| . .  . 
dallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksf

RYWPED----GHQEYGDVAVSVVDVTHMTDWTVRTFlvWVRlHPECMDKREVTQFQFTAWPDQGVPENTAPLIIFHHK---YRYHLSSEE-----TGPIL
.|.|..     . |.|   |.   ... .  . ...   .. |    ..|.|  .|.| |||.||||.  . . . ..    |.. .||        |.|
kyfPkleskkktvefgkfkvttkfsedsdsvittgl..klk.hlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvl

VHCGAGVGRTGTFIAIDSLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVL
||| |||||||  |  | |.  .  . ..|.   .|..|.|| ..|||  || |.|.||
vhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvl
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 19-255 1.2e-56 186.6 In-house 38-290 (301) alignment 
Range on Protein: 19-255
Range on HMM: 38-290/301.0
PYNKTKNRYPNILPYDHSRVVLRARK--DSHGSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCERYWPE--DG
  ||. ||. || .||. |..|.  .  |..  .||||...|||   .|.||||||. .|..|||||||..  ..|||. ... . .| ||.|||.    
eenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseae

HQEYGDVAVSVVDVTHMTDWTVRTFLVWVRLHPE-----------C-MDKREVTQFQFTAWPDQGV-PENTAPLIIFHHKYrYHLSSEETGPILVHCGAG
..|.| . | .|. . . |...| . | ..   .             .. ..|.|.| | ||..|| .|    | . .    .   . . ||..||| ..
seefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvi.hrqqkigggpvvVHCSdt

VGRTGTFIAIDSLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLR
|.|.|......  ..|   ||||||.. .  .| ..  .|.| ||| .||||. 
VsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvid
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 304-544 4.4e-56 185.0 In-house 32-279 (287) alignment 
Range on Protein: 304-544
Range on HMM: 32-279/287.0
VFSRNRERTRNMAAPKRSDNF--SFVAVDTNRIRLSitndIPCSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIE
|  |. | | |.|   .  |    ..  | .|. |         .||||..||.|.|....|....|| ||. .||....... ||||||.....  .  
vtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeev

SELYWPRDGCVRYGKYIVTKIDEEELDDHTQRSM---------DSLLVYHFQYHNWSAHG-MPPRMNGLVFLHEqVQKIQSTEDHGPTVVHCSDGAGRTG
   ||| . .| .|.| .. ..||  .. ..| .         | . |  .|. ||  .| ..     |. ..|   | |  . ... ||||||. ||..
cyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillviee.myktqrkrgntsivvhCsdtvGrsa

VFLALAISIERLEAEDTVDIFQTVRWLRSQRPALVGSIEQYSCCYQAVKSYLS
.|.| |..|.. . | ..|.|| ..  | |.|  |  .|||   ...|  ||.
mfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyld
subfamily_PTPN1_pd Subfamily PTPN1 14-254 4.6e-56 184.7 In-house 25-267 (290) alignment 
Range on Protein: 14-254
Range on HMM: 25-267/290.0
EAAQTPYNKTKNRYPNILPYDHSRVVLRARKDshgsDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCERYWPED
..|..| |...||| .. ||||||..|.  .     |||||..|.     ..|| .||||..|.. ||...||. . ..|||     | .  | .|||..
reaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqg

GHQEYGDVAVSVVDVTHMTDWTVRTFLV-WVRLHP-ECMDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRYHLS-SEETGPILVHCGAGVGRTGTFIA
 ...   .  . . |. ..  . ... | ...|.  .. . ||...| .|.||| ||||  | .. | .| |   | |.. || ..|| ||.||.|||. 
eeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfcl

IDSLMDQMMMEGV---VDVYGFVAQMRTQRNFMVQTHEQYAFIYDVL
.|... ..  ..    ||.   . ..| .|  ..|| .|  | |  .
vdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylai
subfamily_PTPN9_pd Subfamily PTPN9 326-542 5.9e-56 184.7 In-house 51-289 (297) alignment 
Range on Protein: 326-542
Range on HMM: 51-289/297.0
FVAVDTNRIRLSITNDIPCSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWP--RDGCVRYGKYIVTKID
 . .|  |. |. ... ..|.||||...| |.. . .|||| |...|...||.|||||..  ||| | . .||..    |||  .. . ..|.. |....
vlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnve

EEELDDHTQRSMD--------SLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKIQSTE------------DHGPTVVHCSDGAGRTGVFLALAISIERL
 || .|...|..         |  | |||.  |  .|.|   . |. . |.|.. |..             .  | ||||| | |||| | .| |...||
veeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrl

EAEDTVDIFQTVRWLRSQRPALVGSIEQYSCCYQAVKSY
| ..|||...||. ||.||   .   |||  ||.||  |
eevgtvdvvetvkllrtqrafsiqtpeqyefcylavley
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 14-251 1.3e-55 183.2 In-house 1-234 (239) alignment 
Range on Protein: 14-251
Range on HMM: 1-234/239.0
EAAQTPYNKTKNRYPNILPYDHSRVVLRARKDSHGSDYINANFVDGY-GCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCERYWPe
|||.   ||.|||| ||. ||||||||    .   ||||||...  | | |. |||.|| .. .  ||||..|..    ||||       .  | .||| 
eaakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.

DGHQEYGDVAVSVVDVTHMTDWTVRTFLVWVRlhpECMDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRyHLSSEETGPILVHCGAGVGRTGTFIAID
|   .| .. |..     ..|. .|||..         ..| | |..|| |||.|||. .. .. ...|   . |   . | ..|| |||||||.|. ||
dstskycnlrvtlrktevfadyiirtfvmsqv...gqteeryvyqyhftvwpdkgvpqyatavlglrrkit.kdslpgarpwvihcsagvgrtgaflvid

SLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIY
... |   .  ||.. .|  .| .| .|||| ||| ||.
amlrqakkqktvdifnyvkairedrphmvqtseqyvfih
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 15-252 3.2e-55 181.9 In-house 1-234 (239) alignment 
Range on Protein: 15-252
Range on HMM: 1-234/239.0
AAQTPYNKTKNRYPNILPYDHSRVVLRARKDSHGSDYINANFVDGY-GCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCERYWPeD
||.   ||.|||| ||. ||||||||    .   ||||||...  | | |. |||.|| .. .  ||||..|..    ||||       .  | .||| |
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.d

GHQEYGDVAVSVVDVTHMTDWTVRTFLVWVRlhpECMDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRyHLSSEETGPILVHCGAGVGRTGTFIAIDS
   .| .. |..     ..|. .|||..         ..| | |..|| |||.|||. .. .. ...|   . |   . | ..|| |||||||.|. ||.
stskycnlrvtlrktevfadyiirtfvmsqv...gqteeryvyqyhftvwpdkgvpqyatavlglrrkit.kdslpgarpwvihcsagvgrtgaflvida

LMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYD
.. |   .  ||.. .|  .| .| .|||| ||| ||. 
mlrqakkqktvdifnyvkairedrphmvqtseqyvfihl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 325-544 9.2e-55 180.7 In-house 49-277 (281) alignment 
Range on Protein: 325-544
Range on HMM: 49-277/281.0
SFVAVDTNRIRLSITNDIPCSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRDG-CVRYGKYIVTKID
  || |  |.... ...   ..||||.....|.. .||||||.|. .....||||||||| .||||.|.  . |..    ||| |   ..||...|... 
nivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvksta

EEELDDHTQRSMD-------SLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKIQSTEDHGPTVVHCSDGAGRTGVFLALAISIERLEAE-DTVDIFQTV
|||   . .| .        .  | ...| .|  ||.|   . |.  ...|.|..... . | |.||| | ||||...||   ....|||  ..|. ..|
eeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavv

RWLRSQRPALVGSIEQYSCCYQAVKSYLS
. || .|  .| .. ||.  |.||. .|.
aelrkernlmvqtvvqyefvykavldald
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 328-547 1.5e-54 180.0 In-house 54-280 (515) alignment 
Range on Protein: 328-547
Range on HMM: 54-280/515.0
AVDTNRIRLSITNDIPCSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPR--DGCVRYGKYIVTKIDEE
  |..|..| . || | |.|.||||| |..  . |||.|.| . ....||..|.... |.|.|.|.|..  .|    |||      |..|.. |  .  |
PydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsle

ELDDHTQRSM------DSLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKIQSTEDHgPTVVHCSDGAGRTGVFLALAISIERLEAEDTVDIFQTVRWLR
   . ..| .      ||  |  |....|  .|.|.. . |. |  .|.  ..   | | ..||| |.|||||....   . . .  ..||.|..|. .|
actggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyth.pliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnir

SQRPALVGSIEQYSCCYQAVKSYLSWRT
 .|| ||   |||.  |.||. .| || 
qkrpylvqtqeqyafiygavledllwrn
0051429 (Phosphotyrosine protein) phosphatases II 48-259 4.1e-54 179.3 In-house 3-225 (272) alignment 
Range on Protein: 48-259
Range on HMM: 3-225/272.0
GSDYINANFVDGYGC---PQKYIAAQGPLTETIKDFWRLiWEKGCTTIVMLGDTEHKLRSDCERYWP------------EDGHQEYGDVAVSVVDVTHMT
 |.||||..|.|||    | ......|||. |..||||| .| |..|||.| ..| . | .|.||||            ..   .||.. | .. .....
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

DWTVRTFLVWVRLHPECMdkREVTQFQFTAWPDQGVPENTapliiFHHKYRYHLSseeTGPILVHCGAGVGRTGTFIAIDSLMDQMMMEGVVD-------
|...|..|..  |... .  |||.....|.||| |||...     ...  .. |.    ||.|||| ||..||||..|.. |. .. .| .||       
dyilrellltlllsagea..revmhlhytdwpdhgvpqea.....llellellld...ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnl

-VYGFVAQMRTQRNFMVQTHEQYAFIYDVLRDAsL
 ....|...| ||  .||| |||.|.|..|... |
yleeaveelraqrpgavqteeqylflyeallel.l
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 290-540 4.1e-54 178.4 In-house 6-264 (283) alignment 
Range on Protein: 290-540
Range on HMM: 6-264/283.0
DEFEVSLACVASVSVFSRNRERTRNMAAPKRSDNFSFVAVDTNRIRLSITNDipcsEYINASYID---SYNEAHEYIATQAPMENTINEFWQMVWEQKCT
.....    .  .|| ... . . .   ..   |   |..| .|..|   .     .||||..|    ||.. ..||..|.|...|. .||.||...| |
nnnklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekit

AIVMLTELQDRGQIESELYWPRDGCVRYGKYIVTKIDEEELDDHTQRS---------MDSLLVYHFQYHNWSAHGMPPRMNGLVFLhEQVQKIQSTEDHG
||||||.||.  .|.   |||..| . ||.. ||  .|   .  ...           ..||. |.|. .|   |  . .| || . ..|.  |  . .|
aivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkf.nkvislqteskkg

PTVVHCSDGAGRTGVFLALAISIERLEAEDTVDIFQTVRWLRSQRPALVGSIEQYSCCYQAV-K
| ||||| | |||.||.|.. |.. . .|  ||.|..|. .| ||. .| . .||   ...| .
PivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_PTPN6_pd Subfamily PTPN6 290-549 7.7e-54 177.7 In-house 30-303 (306) alignment 
Range on Protein: 290-549
Range on HMM: 30-303/306.0
DEFEvSLACVASVSVFSRNRERTRNMAAPKRSDNfsFVAVDTNRIRLSiTNDIPCSEYINASYID--SYNEAHEYIATQAPMENTINEFWQMVWEQKCTA
.||| .|   .. ...||.. .  . .   |  |   . .| .|. |.  ...| |.||||.||.  . .. ..|||||  .|.|...||.|||..... 
eefe.elqqeeakkllsrkegakpenkeknrykn..ilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrv

IVMLTELQDRGQIESELYWPRDGC-VRYGKYIVTKIDEEELDDHTQRSMDS---------LLVYHFQYHNWSAHGMPPRMNGLV-FLHEQVQKIQSTE--
|||.|.  .||.     |||      .|||. ||...|..|.| . |..             |.......|  ||.|   . .. ||..  .| ...|  
ivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleea

DHGPTVVHCSDGAGRTGVFLALAISIERLEA---EDTVDIFQTVRWLRSQRPALVGSIEQYSCCYQAVKSYLSWRTRA
..||.|||||.| |||| |. . | .. .|    .  .|| ..|. .|.||  ||   .||   |.|.| |.  ....
eagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkkkl
0041856 (Phosphotyrosine protein) phosphatases II 21-266 1.6e-53 176.3 In-house 1-179 (182) alignment 
Range on Protein: 21-266
Range on HMM: 1-179/182.0
NKTKNRYPNILPYDHSRvvlrarkdshGSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGdtehklrsdCERYWPEDGhqeygd
|..||||..||||||||          ..||||||...|.  ....||.|||| .|. ||.|...| |.||||.|          .|.||||.       
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell......

vavsvvdvthmtdwtvrtflvwvrlhpecmdKREVTQFQFTAWPDQGVPEnTAPLIIFHHKYRYhlsseETGPILVHCGAGVGRTGTFIAIDslmdQ---
                               .|...|.... ||| |||. .  |. | .. .      | ||.|||| ||||||||..|..        
...............................erlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaay....lmkk

MmmeGvVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLRDASLCGITEIP
.   | |...  |...| .|. ||.| .|| |....|..  |...|...
l...g.vsleeavklvrsrRpgmvitpnqyfflqlallellllkktrpk
subfamily_CG7180_pd Subfamily CG7180 319-542 1.9e-53 176.0 In-house 44-289 (296) alignment 
Range on Protein: 319-542
Range on HMM: 44-289/296.0
KRSDNFSFVAVDTNRIRLSITNDIPCSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQiESELYWPRDGCVRYGKYI
..  .   |  | ||. |.  .    |.||||.|.||.   .||| |.||...|..|||..|..... |.|.||.  |  .     ||| ..  .||. .
eknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqygeif

VTKIDEEELDDH------------------TQRSMDSLLVYHFQYHNWSA-HGMPPRMNGLVFLHEQVQKIQSTE----DHGPTVVHCSDGAGRTGVFLA
|  . |... .                   .| ...  .| .||.  |   . .|   |.|. | ..|....       ..||.||..||||.|.||.||
veiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvyla

LAISIERLEAEDTVDIFQTVRWLRSQRPALVGSIEQYSCCYQAVKSY
. ...| .| |. ||.|. |. || .|| || ..|.|  .|. .. .
idanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 325-540 2e-53 176.8 In-house 69-288 (319) alignment 
Range on Protein: 325-540
Range on HMM: 69-288/319.0
SFVAVDTNRIRLSITNDIPCSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTelqdrgQIESELYWPRDGCVRYGKYIVTKIDE
  .| | |...|  .. .  |.|||||... |     |||.| |..||...||.|.||..|..||.||      .     ||| .. ...... |     
nilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsv

EELDDHTQRSMD---------SLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKIQSTEDH-GPTVVHCSDGAGRTGVFLALAISIERLEAEDTVDIFQT
|| .... |...            .  | .  |  .|.|     |. | ..|....| |.|  . ||||| |.|||||...| . ..|.. |. ||....
eetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynf

VRWLRSQRPALVGSIEQYSCCYQAVK
|| || ||. || .. ||  .| |. 
vrdlrqqrntlvqdlvqykfiysall
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 326-540 6.5e-53 175.1 In-house 34-252 (284) alignment 
Range on Protein: 326-540
Range on HMM: 34-252/284.0
FVAVDTNRIRLSITNDIPCSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTelqdrgQIESELYWPRDGCVRYGKYIVTKIDEE
 .| | |...|  .  .  |.|||||.|  |   . ||||| |..||...||.|.||..|..||.||      .     ||| .. ...... |     |
ilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsve

ELDDHTQRSM---------DSLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKIQSTEDH-GPTVVHCSDGAGRTGVFLALAISIERLEAEDTVDIFQTV
| .... |..         |   .  | .  |  .|.|     |. | ..|....| |.|  . ||||| |.|||||...| . ..|.. |. ||....|
eseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfv

RWLRSQRPALVGSIEQYSCCYQAVK
| || ||. || .. ||  .| |. 
rdlrqqrntlvqdlvqykfiysall
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 325-544 4.2e-52 172.1 In-house 59-285 (297) alignment 
Range on Protein: 325-544
Range on HMM: 59-285/297.0
SFVAVDTNRIRLSITNDIPCSEYINASYIDSYNEahEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQiESELYWPRDGCVRYGKYIVTKIDE
  . .|..|..| |.|| | |.|.|||.. ....  ..|.|| ||..|...||.||.... ..||||.....| . .   ||. .| . .|.  |.    
niLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsv

EELDDHTQRSMD--------SLLVYHFQYHNWSAHGMPP--RMNGLVFLHEQVQKIQSTEDHGPTVVHCSDGAGRTGVFLALAISIERLEAEDTVDIFQT
.|     .|...          .|  .|. .|  . ..   ... |. | ..|.|  |.. .|| .|||. | |||||.|..   . . . |..||||..
sereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifgl

VRWLRSQRPALVGSIEQYSCCYQAVKSYLS
|. || .|| ||   |||.  |.||  .|.
vkklrqerpylvqtkeqykfvyvavleall
subfamily_PTPN12_pd Subfamily PTPN12 327-544 5e-52 171.6 In-house 50-278 (290) alignment 
Range on Protein: 327-544
Range on HMM: 50-278/290.0
VAVDTNRIRLSITNDIPCSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRDG--CVRYGKYIVTKIDE
.  |..|. || ... . |.||||..|   .. .||||.|.|. .|...||.|.||.. . .||. .. . |..  | |||  |   ...|.. ||...|
lPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleee

EELD-DHTQRS------MDSLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKIQStEDHGPTVVHCSDGAGRTGVFLALAISIERLEAEDT---VDIFQT
. .| |.. |.       .|  || |.|..|  ||.| ... |. | |.|...|. ... | ||||| | ||||. .|. .  | |.|| .   .|.|. 
kavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdl

VRWLRSQRPALVGSIEQYSCCYQAVKSYLS
|. || ||.||| . |||.  |.|| ....
vlelrkqraalvqtkeqyelvykavaelvq
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 332-544 2e-50 166.4 In-house 43-269 (274) alignment 
Range on Protein: 332-544
Range on HMM: 43-269/274.0
NRIRLS-ITNDIPCSEYINASYIDSYNEA-HEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRDGCV----RYGKYIVTKIDEE
 |. |.  ... . |.|||| ||  |.|  . |.||| |. ||...||.|....... |||||.|... .   . |.| .  .    |||.  ..  .  
srvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiv

ELDDHTQRSM------DSLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKIQSTEDH--GPTVVHCSDGAGRTGVFLALAISIERLEAEDTVDIFQTVRW
| .|.. |..      ..  |.|. | .|  |  | ..| |. | ..|.. ...|..  .|.||||| | ||||.|.|  |.. .|..| .||....|  
erndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcn

LRSQRPALVGSIEQYSCCYQAVKSYLS
|| .|  .| . |||   ..|.  ||.
lrldrGGmvqtseqyelihralclylk
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 319-544 1.4e-48 160.7 In-house 52-290 (325) alignment 
Range on Protein: 319-544
Range on HMM: 52-290/325.0
KRSDNfsFVAVDTNRIRLSITNDIPCSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELqDRGQIESELYWPRD--GCVRYGK
 |  |   ||.| .|. |   .| | |.||||||. .. . . ..|.|||. .|||..|..| . .|. .|.| || | |. .   |||..    ...| 
nrfkn..vvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlnel.dlgkdrcavywpkemgksktfGg

YIVTKIDEEELDDHTQRSMD--------SLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKI----QS-TEDHGPTVVHCSDGAGRTGVFLALAISIERL
  |  .  ||. |. .| .|        .. |  ||.  |   | . |   |. . . |...    .. |.  .| .||||.| ||||||..|   ....
levklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakv

EAEDTVDIFQTVRWLRSQRPALVGSIEQYSCCYQAVKSYL-S
  |  ||||. |. || .||..| ...||. .|.|.  .. |
ieesrvdifgfvkklrkdrpsmvetvdqyiliyealveayms
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 332-546 2.3e-48 159.5 In-house 35-267 (270) alignment 
Range on Protein: 332-546
Range on HMM: 35-267/270.0
NRIRLSITNDIPCSEYINASYIDSY-NEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRDG----CVRYGKYIVTKIDEEE
 |.||.  .. . ..|||| |.  . .| ..|||...|...|...||.|.||.| |||||.|.|...|. . | ||| .      ...||  |... || 
tRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseek

LDDHTQRSMD------SLLVYHFQYHNWSAHGMPPRMN------GLVFLHEQVQKIQSTEDHG-PTVVHCSDGAGRTGVFLALAISIERLEAEDTVDIFQ
 . . .. .       .  . ||.|..|  ||.|.. .       |. . ..|.. ..  |.. |..||||.| ||||...|| | .. || .  ||. .
eegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvla

TVRWLRSQRPALVGSIEQYSCCYQAVKSYLSWR
 .. || .|.|||   |||   |.||  | . |
iieelRkdRmalvqhpeqyeflykavveyaerr
subfamily_PTPN14_pd Subfamily PTPN14 318-544 3.7e-48 159.1 In-house 50-297 (300) alignment 
Range on Protein: 318-544
Range on HMM: 50-297/300.0
PKRSDNFSFVAVDTNRIRLSITNDIpCSEYINASYIDSY--NEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRD----GC
 ...    ..  . ||..|| |..   ..||||| |      . ..||..|.|.|.|...||||||||. . |||||| .. |.  |  |.|..      
aeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkkt

VRYGKYIVTKIDEEELDD--------HTQRSMDSLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKIQ--------STEDHGPTVVHCSDGAGRTGVFLA
|..||. ||.   |. |         .   | .   |.|.|| .|. ||.|. ..| .   |.|| ..        |.| . | .||||.|.||||| . 
vefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlil

LAISIERLEAEDTVDIFQTVRWLRSQRPALVGSIEQYSCCYQAVKSYLS
  . |. || ....|| .... || ||  || .. ||   |...  || 
sdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_ptpA1_pd Subfamily ptpA1 7-217 5e-48 158.8 In-house 34-255 (418) alignment 
Range on Protein: 7-217
Range on HMM: 34-255/418.0
LGPRATFEAAQtPYNKTKNRYPNILPYDHSRVVLRARKDSHGSDYINANFVDGyGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDC
.||  | |  .  .| .|||| |||| .|.|| |.  .|  ||||||||..||   |...|..|||| .|| ||||..||. |  ||||     . |  |
vgpsetsegdk.khntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikc

ERYWPED-----------GHQEYGDVAVSVVDVTHMTDWTVRTflVWVRLHPECmDKREVTQFQFTAWPDQGVPENTAPLIIFHHK-----YRYHLSSEE
.|||||.           | . .|  .| .|.| .  .  . |    .||  |  . |..||.|.  |||. .|. | |.  . |       .   ||. 
drywpeqiggeqfsiygngnevfgtysvelveviqdpereiit..rnirltfeg.etrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdr

TGPILVHCGAGVGRTGTFIAIDSLMDQ
  ||.||| ||||||||| .   .| .
nvpiivhcsagvgrtgtfctavimmkk
0036282 (Phosphotyrosine protein) phosphatases II 48-252 6.1e-48 158.1 In-house 1-164 (174) alignment 
Range on Protein: 48-252
Range on HMM: 1-164/174.0
GSDYINANFVDGYGCPQKYIAAQGPLTetikdFWRLIWEKGCTTIVMLGDTEHKLRSDCERYWPEdghqeygdvavsvvdvthmtdwtvrtflvwvrlhP
|||||||...|.. .. ..|| ||||.     ||....| |.||.||| . ... .  | .||||                                   
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..................................l

ECMDKREVTQFQFTAWPDQGVPENTApLIIFHHKYRYHLSSEETGPILVHCGAGVGRTGTFIAIDSLMDQMMmEGVVDVYGFVAQMRTQRNFMVQTHEQY
    .|.. |.... ||| |||. .  |. |    . .||. . ||.|||| ||||||||..|.. .. ... |..||.. .|...|.||  |||| .||
redlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQy

AFIYD
 |.|.
rflyy
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 326-546 1.7e-47 156.6 In-house 49-296 (301) alignment 
Range on Protein: 326-546
Range on HMM: 49-296/301.0
FVAVDTNRIRLSITN--DIPCSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRDGCVR--YGKYIVTK
 . .| ||| |. ..  |.   |||||||||.|.|....||.|.||..|. .||...|..| ..|||.|.|... . ..| |||.    .  .|.  || 
itvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtl

IDEEELDDHTQR-----------------------SMDSLLVYHFQYHNWSAHGM-PPRMNGLVFLHEQVQKIQSTeDHGPTVVHCSDGAGRTGVFLALA
..|  . |.. |                       ...|  |  .|  .|  .|. .     |  ....... |.  . || ||||||. .|.||. .. 
vneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqki.gggpvvVHCSdtVsrsGvYcsvs

ISIERLEAEDTVDIFQTVRWLRSQRPALVGSIEQYSCCYQAVKSYLSWR
|..|   ||  ||.|| .. .| ..|  |  .|||.  |.... ||.  
iglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqln
subfamily_PTPN3_pd Subfamily PTPN3 328-539 3.5e-46 152.4 In-house 52-272 (280) alignment 
Range on Protein: 328-539
Range on HMM: 52-272/280.0
AVDTNRIRLSITNDipcsEYINASYID----SYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRD-GCVRYGKYIVTKI
. |. |..|. ..     .||||.|..    | .    ||||| |...| ..|||||||||.. |||||.| .||..    |||.    ..||.. |.  
pydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPetedeleygefsvkce

DEEELDDHTQRSM--------DSLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKIQSTEDHgPTVVHCSDGAGRTGVFLALAISIERLEAEDTVDIFQT
 |.|   .  | .        ..  . ..|| .|. ||.|   . .. . |.|.|..|.... |.||||| | |||||...| ...  .||.. | . . 
kedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkee.PvvvhCsaGigrtGvlilletalalieaaepvypldi

VRWLRSQRPALVGSIEQYSCCYQA-V
|| .| || .|| . .||    .| .
vrtmrdqramlvqtasqykfvCeail
0043147 (Phosphotyrosine protein) phosphatases II 47-251 1e-44 147.6 In-house 3-154 (172) alignment 
Range on Protein: 47-251
Range on HMM: 3-154/172.0
HGSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTehklrsdcerywpedghqeygdvavsvvdvthmtdwtvrtflvwvrLH
.|||||||...|.| .|...|| |||| .|. ||||...|.|.|.||.| .                                               |.
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..............................................ly

PECMDKREVTQFQFTAWPDQGVPeNTAPLIIFHHKYRYHLSSEETGPILVHCGAGVGRTGTFIAIDSLMdqM-MmegvvDVYGFVAQMRTQRNFMVQTHE
.    .|.. |.... |||.||| ... |. | .  . .|  .. ||.|||| ||||||||..|.. ..  . .     ...  ||..|..|. .||. .
dpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml..lgl.....sleeavalvrekRpgavqnps

QYAFIY
|| |.|
qyrfly
0049772 (Phosphotyrosine protein) phosphatases II 10-258 2.2e-44 147.8 In-house 35-280 (314) alignment 
Range on Protein: 10-258
Range on HMM: 35-280/314.0
RATFEAAQTPYNKTKNRYPNILPYDhSRVVLrARKDSHGSDYINANFVDGYgcpQKYIAAQGPLTETIKDF----------WRLI--WEKGCTTIVM---
. |. .|. . |..||||..|||.| .||.|  . . .|||||||..|||.   .|.||.|||| .|. ||          ||..  ..  . .|||   
eltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrd

---------LGDTEHK--LRSDCERYwpedghqeygdvavSVVDVTHMTDWTvrtflvwvrlhPECMDKREV----TQFQFTAWPDQGVPENTAPLIIFH
         |..  .|  |.. ....              .  .. .. ..            .|. |.  .     ..  . .|| ..|     . ...
evladelsrLdaAlgKtpllildgng..............neptaadlellk...........eelydpelferlgikylripvpDgsaplledfdefle

HKYRYhlssEETGPILVHCGAGVGRTGTFIAIDSLMDQMmmeGVvDVYGFVAQMRTQRN-----FMVQTHEQYAFIYDVLRDAS
.  ..    .. ||.|||| ||.||||||.... || ..   || ..   ....| .|       .... ||| ||...|... 
fieea....dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleyl
subfamily_PTPN13_pd Subfamily PTPN13 328-542 2.6e-44 146.5 In-house 48-268 (273) alignment 
Range on Protein: 328-542
Range on HMM: 48-268/273.0
AVDTNRIRLSITNDipcseYINASYIDS--YNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRD---GCVRYGKYIVTKI
 .|  |..|.         |||||.|     .. .||||.| |. .|...|||||||||.. |.|.|  ...|..  . |||       . .... |...
Pydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevell

DEEELDDHTQRSM--------DSLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKIQSteDHGPTVVHCSDGAGRTGVFLALAISIERLEAEDTVDIFQT
. ..||. ..|..        .|  | |... .|  ||.|   . |. .  .|...|.  |.|| ||||| | ||.|..... . .. .| .  .|. ..
kvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkei

VRWLRSQRPALVGSIEQYSCCYQAVKSY
|| || || ..| . .||  .|.|.   
vrklreqrqgvvqtkdqyifvykailev
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 325-544 3.9e-44 145.8 In-house 56-280 (439) alignment 
Range on Protein: 325-544
Range on HMM: 56-280/439.0
SFVAVDTNRIRLSITNDIPCSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQieselYWPRDGCVRYGKYIVTKIDE
. .| |  |. |  .  .| | |||| ||. | . . |||||.| ..| ..||..|.|.|.. |||||.| .  .     ||| |. | ||  .|    .
dvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrn

EELDDHTQRSMD----------SLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKIQSTEDHGPTVVHCSDGAGRTGVFLALAISIERLEAEDTVDIFQT
 || ... | .              | .|.|  |  . .| .   .. .   ..  . .|. || ||||| | ||||  .|| |..|.| .|. |||   
ielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgi

VRWLRSQRPALVGSIEQYSCCYQAVKSYLS
|. || ||  .| .. ||   |.||   . 
vkvlrkqrkqmvqalcqyvfiynavlediv
0051429 (Phosphotyrosine protein) phosphatases II 342-549 7e-44 145.8 In-house 1-231 (272) alignment 
Range on Protein: 342-549
Range on HMM: 1-231/272.0
IPCSEYINASYIDSYNE---AHEYIATQAPMENTINEFWQMvWEQKCTAIVMLTELQDRGQIESELYWP------------RDGCVRYGKYIVTKIDEEE
.| | ||||.... |.     . ......|...|...||.. .|.....||.|...  ||.   ..|||             .  ..||.. || . || 
lplsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

LDDHTQ---------RSMDSLLVYHFQYHNWSAHGMPPRMngLVFLHEQVQKiqstedHGPTVVHCSDGAGRTGVFLALAISIERLEAEDTVD-------
|.|..             ... |.|..|..|  || |.    |. | |....      .|| .|||| | .|||.. || ........|. ||       
lldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnl

-IFQTVRWLRSQRPALVGSIEQYSCCYQAVKSYLSWRTRA
 ....|..||.|||. | . ||| ..|.|.. .|   . .
yleeaveelraqrpgavqteeqylflyeallellrsllsv
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 312-543 2e-43 143.3 In-house 33-277 (287) alignment 
Range on Protein: 312-543
Range on HMM: 33-277/287.0
TRNMAAPKRSDNFSFVAVDTNRIRLSITNDIpCSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWP-RDG
. ..|| |.      . .| .|. || . .   |.|||| |. ||.. ...||.|.|.  |...||..|.|.. ......|   . .. .   ||| |. 
aeelaavkknryadvlPiddtrvllsaegel.GsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerev

CVRYGKYIVTKIDEEELD-DHTQRSM--------DSLLVYHFQYHNWSAHGMPPRMNGLVFLHEQV-QKI---QSTEDHGPTVVHCSDGAGRTGVFLALA
 .| | | |. .| . .. ... |..        .. .|  ... .| .....|   ||. .  .| |.|   ..... || |||.. |.||.|..||. 
PmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatl

ISIERLEAEDTVDIFQTVRWLRSQRPALVGSIEQYSCCYQAVKSYL
. ..|||    ||. ..|  || .| ||| .. |.   |.|. .| 
vlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyy
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 12-256 3e-43 143.0 In-house 34-275 (307) alignment 
Range on Protein: 12-256
Range on HMM: 34-275/307.0
TFEAAQTpyNKTKNRYPNILPYDHSRVVLRArkDSHGSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCERYWP
| || ..  |  |||| ..   |..|.|..   |   |||| ||..     |.|.|.||||| .|. .|| .. ..   ...|| ..    .  ||.|||
tveafsa..ntdknryqdvkcqdkgrivvkf..dglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywp

EDGHQE--YGDV--AVSVVDVTHMTDWTVRTFLVWVRLHPEC-MDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRYhlsseETGPILVHCGAGVGRTG
 .  |.  .|.   ..|| ..   .      ..    |. .   . | ....|.. |||.|||.     | . .  ||     .| |..||| |||||.|
leegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry.....dtnpvvvhcsaGvGrsG

TFIAIDSLMDQMMM-EGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLRD
| .||  ..|.|.  .   |.  .| ..|.||.. .||  || ... || .
tivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlle
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 19-257 5e-43 142.0 In-house 31-258 (267) alignment 
Range on Protein: 19-257
Range on HMM: 31-258/267.0
PYNKTKNRYPNILPYDHSRVVLRARKDShgsdYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTehkLRSDCERYWPED--GHQ
  |. .||. . ||||..||.|| ...     |||| .|.||   ...|. |.||  || ||. .| ......||.|  .      .  ..||      .
eknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkv...ftdnirlfwPPkmgqak

EYGDVAVSVVDVTHMTDWTVRTFLvwVRLHPEcmDKREVTQFQFTAWPDQgvpENTAPLI--IFHHKYRYHLSsEETGPILVHCGAGVGRTGTFIAIDSL
.| |..|         |. . |.   .... |    ..|| . .  |  .    |  | .  .|    . .|  .   |..|.| .||||.|||. ||| 
kyqdltvehslekeendyqiitle..lkfkne..sahnvtlyyykkwnin...tnnkpylkplfgilaknqle.ngnrPlvvacsdGvGrsGtflvidsq

MDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLRDA
....  |||.|.. |. ..| ||  .|.| |.| .|...| . 
leraktegvsdifdflrkirsqriglvdtkeryiyihellaey
subfamily_PTPN23_pd Subfamily PTPN23 324-540 1.4e-42 140.5 In-house 50-277 (288) alignment 
Range on Protein: 324-540
Range on HMM: 50-277/288.0
FSFVAVDTNRIRLSITNDipcsEYINASYIDSY-NEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPR--DGCVRYGKYIVT
   .  | ||. |  ..|    .|||||.. .    . ..||||||...|.|.||.||.|||   ||||.. ...|. . . |||   .  |..|.. ||
rdilPyDhnRvklrgskD....DYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvt

KIDEEELDDHTQRSMD--------SLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQK---IQSTEDHGPTVVHCSDGAGRTGVFLALAISIERLEAEDT-
  ...|.. | .| .            | | |...|. .|.|   . |. . ..|..    .  . . | ||||| | ||||||  .   .. ||...  
lksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgngl

VDIFQTVRWLRSQRPALVGSIEQYSCCYQAVK
.|| | |. || ||   |   ||.  .|.|| 
ldiiqvvsrlreqRrfmvqekeqlkfsyeavl
subfamily_PTPRN_pd Subfamily PTPRN 320-540 5e-42 138.6 In-house 59-289 (297) alignment 
Range on Protein: 320-540
Range on HMM: 59-289/297.0
RSDNFSFVAVDTNRIRLSITNDIPCSEYINASYI-DSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRDGCVRYGKYI
.  . .... | .|..|. ...   |.||||| | |.   |  |||||.|. .|. .|||||||| .. ||.||.|.. |  . . ||| .|   |. | 
knrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiye

VTKIDEEE-LDDHTQRSM--------DSLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKIQSTeDHGPTVVHCSDGAGRTGVFLALAISIERLE-AEDT
|  . |    ||.  ||.        ..  |  | .  | ..|.|.  . |. .  .|.|        | |||||||||||||.... . ..||      
vhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG.rscpivvhcsdGaGrtGvyilidlvlnrllkGvke

VDIFQTVRWLRSQRPALVGSIEQYSCCYQAVK
.||  |.  || ||| || . .|.  ...|| 
idiaatlehlrdqrpglvktkdqfefaltava
0046846 (Phosphotyrosine protein) phosphatases II 42-253 6.1e-41 135.4 In-house 5-168 (176) alignment 
Range on Protein: 42-253
Range on HMM: 5-168/176.0
ARKDSHGSDYINANFVDGYgcpqKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCERYWPEDGHQEYgdvavsvvdvthmtdwtvrtflv
 . .  ..||||||...|.    ..|| |||| .|. ||.....| |.|..|.| .  .. | .| .||||    ..                       
llgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.......................

wvrlhpecmdkrevtQFQFTAWPDQGVPENtAPLIIFHHKYRYHLSSEetGPILVHCGAGVGRTGTFIAIDslmdQMMMEGVVDVYGFVAQMRTQRN-FM
               |.... ||| |||.  . |. .    | .|..   ||.|||| ||.|||||..|..     .. |  ..|.  .|..| ||  ..
...............qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplga

VQTHEQYAFIYDV
||| ||| |.|..
vqtpeQyrflyef
0049260 (Phosphotyrosine protein) phosphatases II 56-252 1.5e-40 133.7 In-house 1-144 (152) alignment 
Range on Protein: 56-252
Range on HMM: 1-144/152.0
FVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCERYWpedghqeygdvavsvvdvthmtdwtvrtflvwvrlhpecmdkrev
|.|||. |...||.|||. .|..||||...| |.|||||| . . . .  ||.|.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

tQFQFTAWPDQGVPENTAPLIIFHHKYRYHlSSEETGPILVHCGAGVGRTGTFIAIDSLMdqmmmeGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYD
 |.... ||| |||...  |.....  . .   .. ||.|||| ||||||||..|.. ..        |... .||..|..|. .|....|. |.|.
.qylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 327-539 2e-40 133.5 In-house 13-235 (237) alignment 
Range on Protein: 327-539
Range on HMM: 13-235/237.0
VAVDTNRIRLSITNDIpcSEYINASYIDSYNEA-HEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPR-DGCVRYGKYIVTKIDE
|| | .|. |  .     |.||||.|..... . ..|||.| |.|.. ..||||||..||. ||||| | .. ..    |||  |    ||.. |.   .
vaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltvslkkk

EELDDHTQRSMD---------SLLVYHFQYHNWSAHGMPPRMNGLV-FLHEQVQKIQSTEDHGPTVVHCSDGAGRTGVFLALAISIERLEAEDTVDIFQT
||. |.| ||.            |.. .|.  |  .|.| .   |. | .. ... .   . || ..||| | ||||.|| .   . . . .  |||.. 
eefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiyny

VRWLRSQRPALVGSIEQYSCCYQAV
|  .  .|| .. . .||   .|..
vysieedrpyiiqtkdqyvfihqti
0036282 (Phosphotyrosine protein) phosphatases II 345-537 2.9e-40 133.2 In-house 2-164 (174) alignment 
Range on Protein: 345-537
Range on HMM: 2-164/174.0
SEYINASYIDSYNEAHEYIATQAPMEntineFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRdgcvrygkyivtkideeelddhtQRSMDSLLVYHFQ
| |||||..| .    ..||.|.|..     ||.|..|...|..|||.|.. .|      |||.                        |.  . |.....
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.......................lredlerlgiqyl

YHNWSAHGMPPRMNgLVFLHEQVQKIQSTEDHGPTVVHCSDGAGRTGVFLALAISIERLEaEDTVDIFQTVRWLRSQRPALVGSIEQYSCCYQ
| .|  ||.|.    |  . ..|....|  ..||..|||| | ||||.. |. . . .|. |..||....|| ||.|||  | . .||  .|.
ylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
0041856 (Phosphotyrosine protein) phosphatases II 329-543 6e-40 132.1 In-house 13-171 (182) alignment 
Range on Protein: 329-543
Range on HMM: 13-171/182.0
VDTNRirlsitndipCSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTelqdrgqieSELYWPrdgcvrygkyivtkideeeld
.| .|           . ||||......  | ..||||.|. .|...|..|..|...|.||.||         .|||||                     
ydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.....................

dhtqrSMDSLLVYHFQYHNWSAHGMPPrMNGLVFLHEQVQKiqsteDHGPTVVHCSDGAGRTGVFLALAISIERleaedTVDIFQTVRWLRSQRPALVGS
     .    |.....|..|  || |. .. |. . |.|..     ..||..|||| | ||||.. |. . ...      |.....|...||.||  | .
.....ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsleeavklvrsrRpgmvit

IEQYSCCYQAVKSYL
 .||  ...|.  .|
pnqyfflqlallell
subfamily_PTPN1_pd Subfamily PTPN1 329-539 1.5e-39 130.5 In-house 44-267 (290) alignment 
Range on Protein: 329-539
Range on HMM: 44-267/290.0
VDTNRIRLSITNDipcsEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRD---GCVRYG--KYIVTKID
 |  ||.|  ..     .||||| ..  .  ..|| || |. ||.. |||||||||. |.||| .. ...||    |||..    .. .   |. |. | 
ydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvklis

EEELDDHTQRSM--------DSLLVYHFQYHNWSAHGMPPRMNG-LVFLHEQVQKIQSTEDHGPTVVHCSDGAGRTGVFLALAISIERLE---AEDTVDI
||. . .| | .        ..  ..|| |  |.  |.|   .  | ||..  .    ..|.||.|.||| | ||.| |  .   . ..|     ..|||
eerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdi

FQTVRWLRSQRPALVGSIEQYSCCYQAV
 ...  ||..|  |.   .|    |.|.
kkvllelrkyrlGliqtadqlrfsylai
0043147 (Phosphotyrosine protein) phosphatases II 344-542 7.3e-39 128.6 In-house 4-160 (172) alignment 
Range on Protein: 344-542
Range on HMM: 4-160/172.0
CSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELqdrgqieselywprdgcvrygkyivtkideeelddHTQRSMDSLLVYHF
 | ||||||.| |   ...||||.|. ||...||.|..|...|.||.||||                                    . ..  . |....
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...................................lydpellerlgiqy

QYHNWSAHGMPpRMNGLVFLHEQVQKIQSTEDHGPTVVHCSDGAGRTGVFLALAISIerleaeDTVDIFQTVRWLRSQRPALVGSIEQYSCCYQAVKSY
.|..|  || |  .. |  . |......  ...||..|||| | ||||.. |. . .        ......|...|..||  | . .|| ..|.  | .
lylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrflyyfekll
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 328-544 1.9e-38 127.0 In-house 44-260 (267) alignment 
Range on Protein: 328-544
Range on HMM: 44-260/267.0
AVDTNRIRLSITNDIpcseYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQdRGQIesELYWPRD--GCVRYGKYIVTKIDEE
  | .|. |. ...     ||||||...|.  . .|.|| |..||| .|.... .||.. ||.||     ..|   |.||     . .|    | .  |.
pyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvf.tdni..rlfwPPkmgqakkyqdltvehslek

ELDDHT---------QRSMDSLLVYHFQYHNWSAHGMPpRmngLVFLHEQVQKIQSTEDHGPTVVHCSDGAGRTGVFLALAISIERLEAEDTVDIFQTVR
| .|.          . |   . .|... .|  .   |     |  |   . | |  .   | ||.|||| ||.| || .   .||.  |...|||. .|
eendyqiitlelkfknesahnvtlyyykkwnintnnkp.y...lkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflr

WLRSQRPALVGSIEQYSCCYQAVKSYLS
 .||||..|| . |.|  ... .  |  
kirsqriglvdtkeryiyihellaeyae
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 20-255 7.2e-38 124.9 In-house 53-280 (290) alignment 
Range on Protein: 20-255
Range on HMM: 53-280/290.0
YNK--TKNRYPNILPYDHSRVVLrarKDSHGSDYINANFVDGYGcpQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCERYWPEDGHQ-
 |   .|||| ..   | .||.|   || .  ||. ||.|.|      .| .||.|..|. |.||.. ... ..|||| .   . .. ||.|.||   . 
kntefkknrykdvvcndktrvil...kdGydGdyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGev

-EYGDVAVSVVDVTHMTDWTVRTFLVwVRLHpECMDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRyhlssEETGPILVHCGAGVGRTGTFIAIDSLM
  .|...|     ..  . ...  |  ||   .   .  .  ..  .|||. |.  |  |.   .  |     . .||. ||| ||.||||||.||.  .
ltfGeitvlcseeddkdaniikktls.vrdk.dsGkehklkhlkikswpdksvalstlallrtlrilr.....kasGpvvvhcsaGiGrtGtfvaievgl

dQMMMEG-VVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLR
 |....|  .|. . |  .|  |   ||   ||  . ..| 
.qilldGkeldlldlvralrnsrlnsvqvdiqylalveill
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 326-546 7.7e-38 124.9 In-house 54-239 (392) alignment 
Range on Protein: 326-546
Range on HMM: 54-239/392.0
FVAVDTNRIRLSITNDIPCSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGqieselywprdgcvrygkyivtkidee
 .  |..|..| . .||| |.|.|||||.|..  . |||.|.|   ....||.||.... |.|.|.|.|..                             
ilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...........................

elddhtqRSMDSLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVqKIQSTEDHGPTVVHCSDGAGRTGVFLALAISIERLEAEDTVDIFQTVRWLRSQRPAL
       .  |   |  |.. .|  ...| . . |. . ..| |..  .   | ..||| | ||||| ...   . . .    ||.|. |  .| .|| .
.......kgddartvaqfhftewPdkdvpkhtssllkfikev.kadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpym

VGSIEQYSCCYQAVKSYLSWR
| . |||.  | ||   | ||
vqtkeqyafiygavledllwr
0049772 (Phosphotyrosine protein) phosphatases II 325-547 1.8e-37 125.1 In-house 54-284 (314) alignment 
Range on Protein: 325-547
Range on HMM: 54-284/314.0
SFVAVDtNRIRLsITNDIPCSEYINASYIDSYneaHEYIATQAPMENTINEF----------WQMV--WEQKCTAIVM---------------------L
 .. .| || .|  . ..  | ||||||.|..     .||||.|.|.|.. |          |.||  .....  |||                     |
dilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpl

TELQDRGqieselywpRDGCVRYGKYIVtkideEELDDHTQRsmdSLLVYHFQYHNWSAhGMPPRMNGLVFLHEQVQKIqstEDHGPTVVHCSDGAGRTG
..|  .|            .... ...      |||.|.      . |.... .....  | .|  . .  . | ...    ...||..|||..| ||||
lildgng.........neptaadlellk.....eelydpelf...erlgikylripvpD.gsaplledfdeflefieea...dkggpvlvHCkaGkgRtg

VFLALAISIERLeaedTVDIFQTVRWLRSQRP-----ALVGSIEQYSCCYQAVKSYLSWRT
.|...|. . .|     |.. ......|..||      .. . |||  ...|.. ||..  
tfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylkflk
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 14-258 2e-37 123.4 In-house 30-269 (281) alignment 
Range on Protein: 14-258
Range on HMM: 30-269/281.0
EAAQTPYNKTKNRYPNILPYDHSRVVLRA-RKDSHGSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCERYWPE
 . . | |. |||| ||   | ||| |.    .   .||| ||..      . || .|||  ||  ||||.||..  |.|||| .     |  |  |.| 
tvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfpr

DGHQEYGDVAVSVvdvtHMTDWTVRTFLVWVRLHPEC-MDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRyhlsSEETgPILVHCGAGVGRTGTFIAI
. |       .||       | ||   ||  ||      . | .|.. .  |||  ||| .  ..   .| |    .  | | ..|| |||||.||..|.
nahcclqfdklsv....syedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkir....arst.ppvihcsagvgrsgtlmav

DSLMDQMMME-GVVDVYGFVAQMR-TQRNFMVQTHEQYAFIYDVLRDAS
.  .. .     . |.   |...| | |   ||| .|| .|. || |  
eialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfg
0044763 (Phosphotyrosine protein) phosphatases II 32-253 1.3e-36 121.3 In-house 1-166 (178) alignment 
Range on Protein: 32-253
Range on HMM: 1-166/178.0
PYDHSRVVLRARKDSHGSDYINANFVDGYgcpqKYIAAQGPltetiKDFWRLIWEKGCTTIVMLGDTEHKLRSDCERYWPEDGHqeygdvavsvvdvthm
|.|..||.|  . .  .||||||......     |.....|      |...|..| |.|.||.| .. .  . .| .||||. .                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

tdwtvrtflvwvrlhpecmdkrevTQFQFTAWPDQGVPENTAPLIIFHHKYRYHLSsEETGPILVHCGAGVGRTGTFIAIDSLMDQmmmeGVvDVYGFVA
                         |.... .|| |||. .. .  |..  . .|. |. ||.|||| |||||.||..|.. .. .    |. ...  ..
........................iqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaie

QMRTQRNfMVQTHEQYAFIYDV
..| .|. .|.. .|. ..|..
lvrerRp.ivpnpgqlrqLyef
0046846 (Phosphotyrosine protein) phosphatases II 338-543 4.3e-36 119.7 In-house 5-173 (176) alignment 
Range on Protein: 338-543
Range on HMM: 5-173/176.0
ITNDIPCSEYINASYIDSYneahEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRdgCVRYGKyivtkideeelddhtqrsmds
.. . ... ||||..|...     .||||.|...|. .|..|..|...||.|.|||... |..    |||.  . ..|                      
llgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi.....................

llvyHFQYHNWSAHGMPPRmNGLVFLHEQVQKIQSTEdhGPTVVHCSDGAGRTGVFLALAisieRLEAEDTVDIFQTVRWLRSQRP-ALVGSIEQYSCCY
    ......|  || |.  . |  | |.... ..    ||..|||| | ||||...|.      || |  ..........|.|||   | . |||  .|
....qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrfly

QAVKSYL
.... .|
efellll
0051082 (Phosphotyrosine protein) phosphatases II 48-253 1.3e-35 117.5 In-house 2-148 (151) alignment 
Range on Protein: 48-253
Range on HMM: 2-148/151.0
GSDYINANFVDGYgcpqkYIAAQGPLTetikDFWRLIWEKGCTTIVMLGDTEHKLrsDCERYWPEDGhqeygdvavsvvdvthmtdwtvrtflvwvrlhp
 |||||...|.|.     ... .|||     ||..|..| |..|||.| ..|.     | .|.|| |                                 
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

ecmdkREVTQFQFTAWPDQGVPENTAPLIIFHHKYRYhlssEETGPILVHCGAGVGRTGTFIAIDSLMdQMmmegvVDVYGFVAQMRTQRNFMVQTHEQY
     .||...... |||.|.|.... .. |.....      . ||.|||| ||.|||||..|.. .. ..     |...  ....| .|  .||...|.
.....ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylml.lg.....vsleealeeyrlkrpgvvqpnqqf

AFIYDV
 |.. .
lfqlfa
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 19-254 2.1e-35 116.9 In-house 46-283 (305) alignment 
Range on Protein: 19-254
Range on HMM: 46-283/305.0
PYNKTKNRYPNILPYDHSRVVLrarKDSHGSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCERYWPEDGHQ--
  .. |||| ..   |. || |   . .   .|| ||.|     |...| .| || .|  ||| . ...   .| || .   |    |  |.. . ..  
aqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvl

---EYGD-VAV---SVVDVTHMTDWTVRTFLVWVRLHPECMDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRyhlssEETGPILVHCGAGVGRTGTFI
   | |. ..|   | | .   .|   .     . .     ..| ||.. .  |||.|||     .. . .| |        ||| ||| ||.||||. .
efeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekar.....pskgpivvhcsagigrtgsvv

AIDSLMDQMMMEGVVD-VYGFVAQMRTQRNFMVQTHEQYAFIYDVL
 .. ..||..   ...     . ..| |||  .|| .|| |...|.
mleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvi
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 12-255 3.8e-35 116.0 In-house 45-286 (305) alignment 
Range on Protein: 12-255
Range on HMM: 45-286/305.0
TFEAAQTP-YNKTKNRYPNILPYDHSRVVLRarKDShGSDYINANFVDGYGCPQK-YIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCERY
.|.| |..  ..||||| ..   |.| | |   | |  |||| ||.|     |.| .|.||||| .|| .|| .. ..    ||||  |    .  | .|
afnanqsadiaitknryqdvpcqdqsavkld..kps.psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqy

WPED-GHQ--EYGDVAVSVVDVTHMTDWTVRTFLVWVRLHPECMDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRyhlssEETGPILVHCGAGVGRTG
||   | .    . . |  |  ..  .      .  ..|     .|  | ..|.| |||.|||      . .    |         ||.||| ||.||||
wpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsair.....gskvpivvhcsagigrtg

TFIAIDSLMDQMMMEG-VVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLR
| .||. .....  .  .  .  .|  .| || | .|.  || ||. |. 
tivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvml
0049260 (Phosphotyrosine protein) phosphatases II 352-537 4.1e-35 116.1 In-house 1-144 (152) alignment 
Range on Protein: 352-537
Range on HMM: 1-144/152.0
YIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWprdgcvrygkyivtkideeelddhtqrsmdsllvyHFQYHNWSAH
.|| |.  .|.||||.|..||...||.|..|...|.|||||||...| .  | |.                                   ......|  |
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...................................qylhlpwpDh

GMPPRMNGLVFLHEQVQKIqSTEDHGPTVVHCSDGAGRTGVFLALAISIerleaeDTVDIFQTVRWLRSQRPALVGSIEQYSCCYQ
| |.    | ||.. ..|.   ...||..|||| | ||||.. |. . .        |.....|...|..||  | . .|.  .|.
gvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
PTPc_DSPc_SM00012 155-254 1.4e-34 113.8 In-house 2-103 (105) alignment 
Range on Protein: 155-254
Range on HMM: 2-103/105.0
VTQFQFTAWPDQGVPENTAPLIIFHHKYRYHLSSEE-TGPILVHCGAGVGRTGTFIAIDSLMDQMMME-GVVDVYGFVAQMRTQRNFMVQTHEQYAFIYD
|.....|.|||.||||.. ... . .. . . . .| ..|..||| |||||||||.|.| |..|.. | . ||.. .| ..|.||. |||| ||| |.|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

VL
.|
al
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 325-539 5.6e-34 112.3 In-house 16-237 (239) alignment 
Range on Protein: 325-539
Range on HMM: 16-237/239.0
SFVAVDTNRIRLSITNDIPCSEYINASYIDSYNEA-HEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPrDGCVRYGKYIVTKID
  |. | .|. |   .. | |.||||||.  |. . . |||||  .| .  .||.|.|...   ||||| | .  . .   ||| |   .| .  ||   
nivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.dstskycnlrvtlrk

EEELDDHTQRSM--------DSLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKiQSTEDHGPTVVHCSDGAGRTGVFLALAISIERLEAEDTVDIFQTV
 | . |.  |..        .   ||....  |  .|.|     .. |. .. | .|     | |.||| | |||| || .   . . . . |||||. |
tevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyv

RWLRSQRPALVGSIEQYSCCYQAV
. .| .|| .| . |||   . ||
kairedrphmvqtseqyvfihlav
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 325-539 5.7e-34 112.3 In-house 15-236 (239) alignment 
Range on Protein: 325-539
Range on HMM: 15-236/239.0
SFVAVDTNRIRLSITNDIPCSEYINASYIDSYNEA-HEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPrDGCVRYGKYIVTKID
  |. | .|. |   .. | |.||||||.  |. . . |||||  .| .  .||.|.|...   ||||| | .  . .   ||| |   .| .  ||   
nivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.dstskycnlrvtlrk

EEELDDHTQRSM--------DSLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKiQSTEDHGPTVVHCSDGAGRTGVFLALAISIERLEAEDTVDIFQTV
 | . |.  |..        .   ||....  |  .|.|     .. |. .. | .|     | |.||| | |||| || .   . . . . |||||. |
tevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyv

RWLRSQRPALVGSIEQYSCCYQAV
. .| .|| .| . |||   . ||
kairedrphmvqtseqyvfihlav
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 12-178 2.3e-33 110.4 In-house 24-189 (297) alignment 
Range on Protein: 12-178
Range on HMM: 24-189/297.0
TFEAAQTPYNKTKNRYPNILPYDHSRVVLRarKDSHGSDYINANFVDG--YGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCERY
.| .|. .    |||| .|| .| .|| |.  .   ..|||||..|       . ||| ||||| .|..|||.|..|..  .|||.   .   |. |  |
sfssakrnsslrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapy

WPED--GHQEYGDVAVSVVdvTHMTDWTVRTFLVWVRLHPEcMDKREVTQFQFTAWPDQGVPENTAPLIIF
||.   . .. ||| |  .  ....|   | .|  ..|     ..| |.  || .||| ||| .   |  |
wpsvvqerlkagdvvvefl..sstsdefdrviltelqliyr.sesrvvrhvqflswpdhGvpsdledlvrf
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 11-253 3.4e-33 109.5 In-house 44-285 (310) alignment 
Range on Protein: 11-253
Range on HMM: 44-285/310.0
ATFEAAQTpyNKTKNRYPNILPYDHSRVVLRARKDSHGsDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCERYW
 |.|| .   .  |||| ...  | ||| |.  |  .. ||| ||.|      . .| .||||  || ||||.|... . .|..|  . .. |  |  ||
ltyeaykk..ymhknrysdvvcldtsrvklkidksrye.dyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgyw

PEDGHQE-YGDVAVSVVD----VTHMTDWTVrTFL---VWVRLHPECMDKREVTQFQFTAWPDQGVPENTApliifHHKYRYHLSSEETGPILVHCGAGV
|  |  | || . |. .        . . .| ||.   | |   |  ...  |.  ..  |||.|||..       |   .  |.    || .||| ||.
pslgvtetygcirvtnlsesseefeicnlav.tfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekc.....htvpqrllaqvrhgpcvvhcsagk

GRTGTFIAIDSLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDV
.|... .|..  .|..     ||.   ..... .|   .||. || .|  |
drlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrv
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 8-256 7.6e-33 108.7 In-house 24-268 (285) alignment 
Range on Protein: 8-256
Range on HMM: 24-268/285.0
GPRATFEAAQTpyNKTKNRYPNILPYDHSRVVLRarkdSHGSDYINANFVDGYGCPQ-KYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDC
 | .|. | ..  |   ||| ..   . .||||.     |  ||| |...   |  |  ||..|||| ||. |||..|...  . ..||          |
ppnctytayea..npdlnryadvrcieetrvvlk....nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekc

ERYWPEDGH--QEYGDVAVSVVDVTH-MTDWTVRTFLVWVRLHPECMDKREVTQFQFTAWPDQGVPENTAPLIIFhHKYRYHLSSEETgPILVHCGAGVG
  |.||      ..|   ... ..       |.   |  .     . .   . . |   ||||  ||.. |.| . .|.  ..  .|. || ||| ||||
alyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmiel.ykwvkkvnpkek.picvhcsagvg

RTGTFIAIDSLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLRD
|| ||. ||    ..| .  ...   | .||. |   ||.| |. |.| || .
rtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlme
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 324-540 3.1e-32 106.6 In-house 40-292 (297) alignment 
Range on Protein: 324-540
Range on HMM: 40-292/297.0
FSFVAVDTNRIRLSitNDIPCSEYINASYIDSYNEAHE--YIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPR--DGCVRYGKYIV
   .|.|..|..|   . |. ..|||| |.   .| ..  || .| |...|...||..|.||   .|||...||. |.     |||.  ..  . |...|
rdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvv

TKIDEEElDDHTQRS---------MDSLLVYHFQYHNWSAHGMP--------------------PRMNGLVF-----LHEQVQKIQSTED-HGPTVVHCS
  . .   |.. .            .|  | | |. .|  ||.|                    | | .||      .  |.. ...      ...||||
eflssts.defdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraemprnayllvhcs

DGAGRTGVFLALAISIERLEAEDTVDIFQTVRWLRSQRPALVGSIEQYSCCYQAVK
 | ||.|| .   . ...|  .   |.   .. ||.||. || ..||.  .|.|| 
aGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavl
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 19-248 3.3e-32 106.4 In-house 48-271 (301) alignment 
Range on Protein: 19-248
Range on HMM: 48-271/301.0
PYNKTKNRYPNIlPYDHSRVVlRARKDSHGsDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCERYWPEDGHQE-
  .| |.|||.. | . |  | .  .| .    | ||...  | |...||.||||..| .||| ..      .||||| .  || . || | | . ... 
ylpkdkhryptv.PckPstav.evivdGkr.vPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekl

-YGDVAVSVVDVTHMTDWTVRTFLVWVRLHPECMDKREVTQFQFTAWPDQGVPENTAPLiiFHHkyrYHLSSEETGPILVHCGAGVGRTGTFIAIDSLMD
  |   . ...  .. .  .    . |.   . .. | || .|.. |.|.|||.  | |  |.     .|  .   ||.||| ||.||. .||. . |  
digrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshael..fdl...melvkksekPivvhcsaGiGrsvafigteylar

QMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYA
..  .  ...   ....| .|   |||..|  
eveadptieltealkhlrehrwngvqtnsqly
0051082 (Phosphotyrosine protein) phosphatases II 344-538 1.4e-31 104.5 In-house 2-148 (151) alignment 
Range on Protein: 344-538
Range on HMM: 2-148/151.0
CSEYINASYIDSYneaheYIATQAPMEntinEFWQMVWEQKCTAIVMLTELQDRGqiESELYWPRDGcvrygkyivtkideeelddhtqrsmdsLLVYHF
 | |||.||....     ......|..    .|.....|.....||.|.... ||      |.|. |                           . |.|.
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg...........................ievlhi

QYHNWSAHGMPPRMNGLVFLHEQVQKiqstEDHGPTVVHCSDGAGRTGVFLALAISIERleaedtVDIFQTVRWLRSQRPALVGSIEQYSCCYQA
....|...|.|   . .. ..|....     ..||..|||| | ||||.. || . ...      |.........|..|| .| . .|. ....|
pildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfa
0044763 (Phosphotyrosine protein) phosphatases II 329-546 2.2e-31 104.2 In-house 2-174 (178) alignment 
Range on Protein: 329-546
Range on HMM: 2-174/178.0
VDTNRIRLSITNDIPCSEYINASYIDSYneaheYIATQAPMentiNEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRDGCvrygkyivtkideeeld
.| .|  ||   ....|.|||||.|. .     ......|.     .......|...|.||.||| . .|....  |||..                   
ldrtrvllsnleglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag.................

dhtqrsmdsllvYHFQYHNWSAHGMPPRMNGLVFLHEQVQKIQStEDHGPTVVHCSDGAGRTGVFLALAISIERleaedTVDIFQTVRWLRSQRPaLVGS
            ..... ... || |. .  .  ..| ...... |..||..|||| | ||.|.. |. . ...      ..... ....|..||  | .
............iqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpn

IEQYSCCYQAVKSYLSWR
 .|.  .|.  . .|...
pgqlrqLyefelrllkes
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 21-254 3.2e-30 100.1 In-house 43-267 (288) alignment 
Range on Protein: 21-254
Range on HMM: 43-267/288.0
NKTKNRYPNILPYDHSRVVLRarKDSHgsDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCERYWPEDGHQ-EYG
| |..|| |.   | .|| |    |..   ||.|| |     ... | || ||  ||. .|... |..   |||| .   | .   . |.|    .    
nptrdryenlprcditrvkls..ddpd..fyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekari

DVAVSVVDVTHmTDWTVRTFLVWVRLHPECMDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYryhlsSEETGPILVHCGAGVGRTGTFIAIDSLMDQMM
    .|| . . .|      .  .| . |  .|  | .  .  |.|.|||||  . . . .        . . ||.||. ||||||||.| |   .... 
grlctvvkkkr.adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililialeslr

MEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVL
..  . .  ..|..| .|   .||  || ... ..
lddflgirsllaklreerfkaiqtemqylyvhrcv
PTPc_DSPc_SM00012 440-540 2.6e-29 96.9 In-house 2-104 (105) alignment 
Range on Protein: 440-540
Range on HMM: 2-104/105.0
VYHFQYHNWSAHGMPPRMNGLVFLHEQVQKIQSTED-HGPTVVHCSDGAGRTGVFLALAISIERLEAE-DTVDIFQTVRWLRSQRPALVGSIEQYSCCYQ
|.|..|..|. ||.| ... .. | ..|.| .. .. ..|.|||||.|.||||.| ||.| ...||.| ..|||||.|. ||.||| .| . |||. .|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AVK
|..
all
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 64-253 4.4e-29 96.1 In-house 5-199 (199) alignment 
Range on Protein: 64-253
Range on HMM: 5-199/199.0
QKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCERYWP--EDGHQEYGDVAVSVVDVTHMTDWTVRTFlVWVRLHPECMDKREVTQFQFT
..|||.| || ||. |||...|| |   |||. | ...  .|   |||  | |  .|| ..|..  .|   |.|. .. . .         ||....|||
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytital.iltnnttappstreishyqft

AWPDQGVPeNTAPLIIF---HHKYRYHLSSEETGPILVHCGAGVGRTGTFIAIDSLMD--QMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDV
.| ..  | | | .. |     .   .   |   |..|||  | | || |.|.|  .   .     |||..    ..|  |  .. . ..| |||.|
swkekttp.nvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 64-253 4.4e-29 96.1 In-house 4-198 (198) alignment 
Range on Protein: 64-253
Range on HMM: 4-198/198.0
QKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCERYWP--EDGHQEYGDVAVSVVDVTHMTDWTVRTFlVWVRLHPECMDKREVTQFQFT
..|||.| || ||. |||...|| |   |||. | ...  .|   |||  | |  .|| ..|..  .|   |.|. .. . .         ||....|||
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytital.iltnnttappstreishyqft

AWPDQGVPeNTAPLIIF---HHKYRYHLSSEETGPILVHCGAGVGRTGTFIAIDSLMD--QMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDV
.| ..  | | | .. |     .   .   |   |..|||  | | || |.|.|  .   .     |||..    ..|  |  .. . ..| |||.|
swkekttp.nvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 309-547 1.3e-28 94.9 In-house 46-275 (288) alignment 
Range on Protein: 309-547
Range on HMM: 46-275/288.0
RERTRNMAAPkrsdnfsfvavDTNRIRLSitNDipCSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPR
|.| .|.              |. |..||  .|  .  ||.|  . | .  .  | .|||.. ||.|.|.|. |.    ||||.|| ..|. .|. |.| 
rdryenlprc...........ditrvkls..dd..pdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPs

D--GCVRYGKYI-VTKIDEEELDD-------HTQRSM-DSLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVqkiqsTEDHGPTVVHCSDGAGRTGVFLALA
     .|.|..  |.| . ...|        . .. . .. .| .  ...|  .|.|      . | | .      . . | |||.| |.|||| .    
klGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlilil

ISIERLEAEDTVDIFQTVRWLRSQRPALVGSIEQYSCCYQAVKSYLSWRT
| .| |  .| . | . .  || .|   . .  ||   .. |. .|  . 
ialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelllkk
subfamily_CG42327_pd Subfamily CG42327 19-178 3e-28 93.4 In-house 26-186 (319) alignment 
Range on Protein: 19-178
Range on HMM: 26-186/319.0
PYNKTKNRYPNILPYDHSRVVLRARKDSHGSDYINANFVDGYG-CPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCERYWPE----D
.  | |.|. |..|  ..||||.   |   . |..|..| ||  .|  ||||| .| ..  ||||..||.   .|| | |   .    | .|.|     |
vtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketld

GHQEYGDVAVSVVDVTHMTDWTVRTFLVwVRLhpECMDKREVTQFQFtAWPDQGVPENTAPLIIF
... |||. |.. .      . . |.|.  |.  .    ||.| . .  |.. .|| . |.||  
ntslyGdilvtlkgrevkdryaistlll.krv..dkeesrelthywy.kwleaevPaeeaaliam
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 360-537 4.9e-28 92.7 In-house 5-198 (199) alignment 
Range on Protein: 360-537
Range on HMM: 5-198/199.0
HEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPR--DGCVRYGKYIVT------KIDE----EELDDHTQRSMDSLLVYHFQYHN
. ||||| |. .|. .|||||||     |||. . |   . .  .|||    |. .||   ||      | |       | . |     .  . |.|.  
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WSAHGMPP--RMNGLVFLHEQVQKIQSTEDHGPTVVHCSDGAGRTGVFLALAISIERLEAEDT--VDIFQTVRWLRSQRPALVGSIEQYSCCYQ
|  .  |    . |.|    .| |    |   | .|||||| | ||||.|| | .   |   |  ||.|.  . ||  |  .. |...|   ||
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 360-537 5.4e-28 92.5 In-house 4-197 (198) alignment 
Range on Protein: 360-537
Range on HMM: 4-197/198.0
HEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPR--DGCVRYGKYIVT------KIDE----EELDDHTQRSMDSLLVYHFQYHN
. ||||| |. .|. .|||||||     |||. . |   . .  .|||    |. .||   ||      | |       | . |     .  . |.|.  
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WSAHGMPP--RMNGLVFLHEQVQKIQSTEDHGPTVVHCSDGAGRTGVFLALAISIERLEAEDT--VDIFQTVRWLRSQRPALVGSIEQYSCCYQ
|  .  |    . |.|    .| |    |   | .|||||| | ||||.|| | .   |   |  ||.|.  . ||  |  .. |...|   ||
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_egg_pd Subfamily egg 11-254 1.2e-27 91.5 In-house 30-266 (307) alignment 
Range on Protein: 11-254
Range on HMM: 30-266/307.0
ATFEAAQTPYNKTKNRYPNILPYDHSRVVLRARKDSHGSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKlrSDCERYW
 ... | .  |..| | . .   | ||| |. |.  .  |.| || |.|     ..| || || .| .||||..... .  ||||  . .     || ||
islttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyyw

PEDGHQE--Y--GDVAVSVVDVTHMTDWTVRTFLVWVrLHPEcmdkREVTQFQFTAWPDQGVPENTAPLIIFHHkYRyhlssEETGPILVHCGAGVGRTG
|    .   .  | . .  ..| . .|   |   . . . ..    .|    .   .  . . .   || .. .  |     . . |..|..  || ...
pkaesdslvtvpGslrienlkvdskadplfrvtklkl.vGgd....deerflehwqgdvnnssdvysplrvlrk.lr.....nlskpvvvqdilGvskaa

TFIAIDSLMDQMMMEGVV--DVYGFVAQMRTQRNFMVQTHEQYAFIYDVL
|..||.  . ...   ..   |   |  .| .|.. |..  .| |.| ..
tlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlv
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 328-538 1.8e-26 87.5 In-house 64-278 (290) alignment 
Range on Protein: 328-538
Range on HMM: 64-278/290.0
AVDTNRIRLSITNDIPCSEYINASYIDSYNEahEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRD-G-CVRYGKYIVTKIDEE
 |  | .   | .|    .|. | |..  .    .| || ....|. ..|.|| ..| .||||| || . |.   | |.|   |  . .|.. |.   |.
dvvcndktrvilkdGydGdyvhanyvkGlka..mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseed

ELDDHTQRSMDS---------LLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKIqstedHGPTVVHCSDGAGRTGVFLALAISIERLEAEDTVDIFQTVR
. |..... . |           ..|..   |  . ..     |. .   ..|.      || ||||| | |||| | |. .... |     .|. ..||
dkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka.....sGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvr

WLRSQRPALVGSIEQYSCCYQA
 ||  | . |    ||    ..
alrnsrlnsvqvdiqylalvei
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 331-546 1.4e-25 85.0 In-house 53-280 (307) alignment 
Range on Protein: 331-546
Range on HMM: 53-280/307.0
TNRIRLSITNDIPCSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRDGC--VRYGK---YI-VTKIDE
 .. |. .. |  .|.|| | |.    . . .|..| |.|||. .|| |. ..|  ...|| .. . ..|  | ||| .      .|.    | |...  
qdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlga

EE------LDDHT----QRSMDSLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQkiqstEDHGPTVVHCSDGAGRTGVFLALAISIER-LEAEDTVDIFQ
..      | . |    . . .|  . |.|..||  .|.|.   . . | | |.      |. | ||||| | ||.|  .|...  .. .. ..  |. .
kklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavr.....ydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkk

TVRWLRSQRPALVGSIEQYSCCYQAVKSYLSWR
 |. |||||.  . .  ||   .. . .|.  .
lveelrsqrhyaiqteaqylylhrvlleyflel
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 150-283 1.8e-25 84.1 In-house 86-219 (440) alignment 
Range on Protein: 150-283
Range on HMM: 86-219/440.0
MDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRYHLSSEETGPILVHCGAGVGRTGTFIAIDSLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAF
.. | . |... .|||.|||. ..|.. . .           ||.|||| ||.||||  ||.||.. .      .|.. |.  || .|  |||| |||||
iesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf

IYDVLRDASLCGITEIPSQEIASSLLVLRDNDPD
..... .. ||| | |  ..|.  .  ..  .| 
vheavlegllcgdtliledditerveqiqwpnph
0048076 (Phosphotyrosine protein) phosphatases II 119-254 2e-25 84.5 In-house 14-139 (145) alignment 
Range on Protein: 119-254
Range on HMM: 14-139/145.0
GDVAvSVVDVTHMTDWTVRTFLVWVRLHPECMdkREVTQFQFTAWPDQGVPENTAPLIIFHHKYRYHLSSEetGPILVHCGAGVGRTGTFIAIDslmdQM
|..  ...|. .. |. ..| |   .  . .   |...|.... ||| |||. .. |. | .  . .|...  ||.|||| ||||||||..|..     |
gslp.taldlellkdlgittvlnltselelle..rlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaay....lm

MMEGvVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVL
...| |...  ....|.|| ..|.. .|. |.|...
lllg.vsleealelvrsqrpgavpnpgqlrflyefe
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 320-544 3.4e-25 83.1 In-house 56-286 (302) alignment 
Range on Protein: 320-544
Range on HMM: 56-286/302.0
RSDNFSfvAVDTNRIRLSITNDipcsEYINASYIDSYNEAHEYIATQAPMENTI---NEFWQMVWEQKCTAIVMLTELQDRGQIESElYWP--RDGCVRY
.|...   ..|.|...|. ..|    .|.||| ..  .  .. | .| |  ..    .|||.||...|.. .|.|   ..  .  || ..|   .  . |
qsedvp..ildsnlvkleaepd....syvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlse.lfpkksgdykey

GKYIVTKIDEEELDDHT---------QRSMDSLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVqKIQSTEDHGPTVVHCSDGAGRTGVFLALAISIERLEA
||  | .   |. ....         .   .|.|.     .|| .. .| ... |.   ..|   ....   .||.    |||| |.||.||...|.|..
gkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGRagafltlavaveklqk

EDTVDIFQTVRWLRSQRPALVGSIEQYSCCYQAVKSYLS
.. . | ..|. .|||||. | |..||   | |.  |. 
gkepnikeivksiRsqRpravdslkQyvslyialllyik
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 325-538 2.2e-24 80.6 In-house 45-264 (281) alignment 
Range on Protein: 325-538
Range on HMM: 45-264/281.0
SFVAVDTNRIRLSI-TNDIPCSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRD--GCVRYGKYIVTK
   ..|  |..| .   .   ..|| | || |    . || || | ..|  .||.|.|... |||||| .. .  . .   |.||.   |... |. |. 
nipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsy

IDEEELDD----HTQRS--MDSLLVYHFQYHNWSAHGMPPRMNglVFLhEQVQKIQSTedHGPTVVHCSDGAGRTGVFLALAISIERLEAEDTV-DIFQT
 |          . . |   .. |. |. ...|    .|   .  |.| . ..||..     | |.||| | ||.| ..|. |... . .  |. || | 
edstvnkslvttrlnlsyegetrlithwlwkewpdwqvpesse..vml.kilrkirar..stppvihcsagvgrsgtlmaveialqsihshftlpdikqi

VRWLRS-QRPALVGSIEQYSCCYQA
|  ||   | | | ...||   .. 
vshlrvtgraasvqtlqqymliwkv
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 22-252 2.4e-24 80.6 In-house 44-270 (312) alignment 
Range on Protein: 22-252
Range on HMM: 44-270/312.0
KTKNRYPNILPYDHSRVVLRARKdshgSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCERYWP-------EDG
|  ||||||  .|  |  |   .      || ||||     |......|||| .|.  ||.|    |.|.|..|    .     | .|          . 
kdlnrypniqcwdrgrftlagde....nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdled

HQEYGDVAVSVVDVTHMTD-WTVRTFLVWVRLhpeCMDKREVTQFQFTAWPDQGVPENTAPLiifhHKYRyHLSSEETGPILVHCGAGVGRTGTFIAIDS
|. | .    .    .  |  | | . | |.      ..  . ..|...|||.|.|.         ..        .  |.. || ||||||||.. |.|
hrvyteycteieiggkskdkithrvlkvvvka...tgqesklnhyqwaswpdhgmpdscdta....lrll.savkkdkkpviahcsagvgrtgtlalies

LMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYD
..  .      .|      .| .|   |..  || .   
miaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalr
0048179 (Phosphotyrosine protein) phosphatases II 124-252 2.4e-24 81.1 In-house 18-139 (144) alignment 
Range on Protein: 124-252
Range on HMM: 18-139/144.0
SVVDVTHMTDWTVRTFLVWVRLHPECMDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYRYHLSseETGPILVHCGAGVGRTGTFIAIDslmdQMMMEGv
...|. .. .. ..| .  .  ..    .||..|.... ||| |||. .. |. | .  . .|.  | ||.|||| ||||||||..|..     |...| 
taldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaay....lmkklg.

VDVYGFVAQMRTQRNFMVQTHEQYAFIYD
....  .|..|..| ..|.. .|. |...
lsleealalvrsrrpgavpnpgqlrfLle
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 22-117 2.4e-23 77.4 In-house 48-157 (350) alignment 
Range on Protein: 22-117
Range on HMM: 48-157/350.0
KTKNRYPNILPYDHSRVVLR-------ARKDSH-GSDYINANFVDGY------GCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCE
 .|||| |||||.|||| |.       |.| |. ..||||||..             ||||.|.|| .|..||...| . . . |..| .     .  |.
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

RYWPEDGHQE
|||.| . ..
rYWqegsydd
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 348-531 5e-23 76.3 In-house 78-269 (301) alignment 
Range on Protein: 348-531
Range on HMM: 78-269/301.0
INASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRDG--CVRYGKYIVTKIDEEE-LDDH-TQRS---------
| | .|..  ..| .||||.|..|| ..|| |.   .   ||||..  .. .   | | | .    .. |.. ..  ..|  |... ..|.         
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

MDSLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKiqsTEDhgPTVVHCSDGAGRTGVFLALAISIERLEAEDTVDIFQTVRWLRSQRPALVGSIEQ
...  | |.||..|...|.|     |  | | |.|   .|.  | |||||.| ||.  |..  .   ..||. |... .... || .|   |   .|
fatrtvthyqysewtdrgvPkshaelfdlmelvkk...sek..PivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsq
subfamily_egg_pd Subfamily egg 326-541 5.1e-22 72.9 In-house 49-268 (307) alignment 
Range on Protein: 326-541
Range on HMM: 49-268/307.0
FVAVDTNRIRLSITNDIPCSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRgqIESELYWPRD--GCVRY--GKYIVTK
    |. |..| . .     ..| | ...      |.| .|||. || ..||.||.....  |||||  ..    . | |||.     ...  | . .. 
vhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrien

IDEEELDDHTQRSMDSLLVYHFQYHNWSAHGMpPRMNGLVFLHEQVQKIQST-EDHGPTVVHCSDGAGRTGVFLALAISIERLEAEDT--VDIFQTVRWL
.. ..  |   |     ||   .   .  |     .| .  ..  .. ..   .   |.||.. .|  ......|. |..  |    .    . ..| .|
lkvdskadplfrvtklklvGgddeerflehwq.gdvnnssdvysplrvlrklrnlskpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvfl

RSQRPALVGSIEQYSCCYQAVKS
| .|.  | |. .|   |. |  
rlrrrlsvesvllylfvyrlvlf
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 325-524 7.8e-22 72.2 In-house 60-271 (310) alignment 
Range on Protein: 325-524
Range on HMM: 60-271/310.0
SFVAVDTNRIRLSITNDiPCSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRDGCV-RYGKYIVTKID
  |  || |..| | .     .|| | |. .      .| .| |.. || .||.|...... .|..|    . |.  .  |||  |    ||   ||.. 
dvvcldtsrvklkidks.ryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnls

EE--E---------------LDDHTQRSMDSLLVYHFQYHNWSAHGMPPRMnglvfLHEQVQKIQSTEDHGPTVVHCSDGAGRTGVFLALAISIERLEAE
|   |                 |     .. | |   .. ||   |.|         |   |.. .   ||| ||||| | .|..| .|| ..|..|.  
esseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdek.....chtvpqrllaqvrhgpcvvhcsagkdrlyvvvalklkidkldrg

DTVDIFQTVRWLRSQRPA
. ||. . .  |. .|  
lkvdaeevktellksrai
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 21-253 8.7e-21 68.6 In-house 51-280 (302) alignment 
Range on Protein: 21-253
Range on HMM: 51-280/302.0
NKTKNRYPNILPYDHSRVVLRARKDshgsDYINANFVDGYGCPQKYIAAQGPLTETI---KDFWRLIWEKGCTTIVMLGDTEHKLRsDCERYWP--EDGH
|  ||. ...  .|. .| | |..|    .|.||  |.   . .. | || | ...     .|||..... ....|.|  .|   .   . ..|   . .
nlkknqsedvpildsnlvkleaepd....syvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdy

QEYGDVAVSVVDVTHMTDWTvRTFLVWVrLHPECMDKREVTQFQFTAWPDQGVPENTAPLIIFHHKYrYHLSSEETGPILVHCGAGVGRTGTFIAIDSLM
.|||.. | .  | .. . .   . . | |  .| .   ..   .| |... ||.. | ||   .|  ...... . ....    |.|| |.|..    .
keygkmfvNnrkVekaeeek.tryviEv.lPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGRagafltlavav

DQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDV
...  .  . .   |...|.||  .|.. .||...| .
eklqkgkepnikeivksiRsqRpravdslkQyvslyia
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 23-252 8.7e-21 69.3 In-house 21-253 (290) alignment 
Range on Protein: 23-252
Range on HMM: 21-253/290.0
TKNRYPNILpYDHSRVVLRARKDSHGSDYINANFVDgYGCPQKYIAAQGPLTET-------IKDFWRLIWEKGCTTIVMLGDTEHKLRS----DCERYWP
 ..|... |   ..||||.  .    .||| ||.|  .   .. |. | |....       |..|| .. .   . .|||.. | | .      |..| |
mdqRlevpL.veatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvp

ED--GHQEYGDVAVSVVDVTHMTDWTVRTFLVWVRLHPECmdkrEVTQFQFTAWPDQGVPENTAPLIIFHHKyryhLSsEETGPILVHCGAGVGRTGTFI
|   ..  .... |.  .  .  |  .|. .|    . |      ||  ..  | .  |.|.|  |.   .|    .   .. |..|||  |. |  .. 
esvgeelkfkgltvkCkskekeddvetRelvvkfddeeef....tvtHsllkgWnklnvqedtktllsliqk....vk.asktpvivHcvdGiSrsAala

AIDsLMDQMMM--EGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYD
||. |  |...  .| | .   . ..| ||. ........||.  
aii.lgyQkiaetsgsvkledvlkalrkqralaitsalelafvda
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 345-542 1.3e-20 68.6 In-house 59-269 (285) alignment 
Range on Protein: 345-542
Range on HMM: 59-269/285.0
SEYINASYIDSY-NEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRD--GCVRYGKYIVT--KIDEEELDDH---------
 .|| ||..    ..   ||.|| |. .|...||.|....| . ..||  | . |  .  ||.|      |..||| .|  .  || .            
rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvin

-TQRSMDSLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKIQSTEDhgPTVVHCSDGAGRTGVFLALAISIERLEAEDTVDIFQTVRWLRSQRPALVGSI
  . | . | . | |   |  .  |     .. |.. |.|..  |   | .|||| | |||  |. .  .  |.  .  ..... || .|. |   | | 
tedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkek..picvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqsh

EQYSCCYQAVKSY
 |.   |  .  |
mqflflyvvlmey
subfamily_ptpA1_pd Subfamily ptpA1 270-409 4.8e-20 66.7 In-house 6-138 (418) alignment 
Range on Protein: 270-409
Range on HMM: 6-138/418.0
IASSLLVLRdNDPDIIRQRQDEFEVSLACVASVSVfSrNRERTRNMAaPKRSDNfsFVAVDTNRIRLSITNDIPCSEYINASYIDSYNeAHEYIATQAPM
| ||.  |. |    |.. ..|| .    |      | . .. .| .  .|  |   . |.  |..|   .|   |.|||| |||     ...|.|| |.
ikssiynlk.nhikcihkikeefrlleesvgpset.s.egdkkhnts.knrytn..ilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgpl

ENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRD
 ||| .||.||||..|  ||||.   .  .|. . ||| .
pntiadfwrmvwenrcriivmlsresencrikcdrywpeq
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 330-542 4.8e-20 66.4 In-house 68-288 (305) alignment 
Range on Protein: 330-542
Range on HMM: 68-288/305.0
DTNRIRLsitNDIPCSEYINASYIDSY-NEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRDGC----VRYGkYIVTKID-
| . ..|   .. . |.|| | |.       . .|..| |...||.||| || ..|   ||||    . |..    |||        .. |  .| ..  
dqsavkl...dkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksg.ivvenvsg

--EEELDDHTQRSM--------DSLLVYHFQYHNWSAHGMPPRMNGLVflhEQVQKIQSTedHGPTVVHCSDGAGRTGVFLALAISIERL-EAEDTVDIF
    | |   | ..        ... | |.|. .|   |.||     .   | .  |. .  . | ||||| | ||||  .|.   .|.. |  .   . 
skpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltsl...ellsairgs..kvpivvhcsagigrtgtivaieyilekiaenkpcppmp

QTVRWLRSQRPALVGSIEQYSCCYQAVKSY
. |. || ||   . .  ||   .. .  |
elvkalrdqrafsiqndvqylfihrvmlny
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 75-251 1.5e-19 65.1 In-house 39-214 (255) alignment 
Range on Protein: 75-251
Range on HMM: 39-214/255.0
ETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCERYWP--EDGHQEYGDVAVSVVDvtHMTDWTVRTFLVWVRLHPeCMDKREVTQFQFTAWPDQGVPENT
 |.. |.. |  .. ...|||.| . . . .|..|.|   |... . ||.|.. .   ..|  .||  .   |       ..|. .... |...  ||..
ltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlge.kkkthtvkhysykGWieknaPela

APLIifhhkYRYHLSSEEtGPILVHCGAGVGRTGTFIAIDSLMDQMMME------GVVDVYGFVAQMRTQRNFMVQTHEQYAFIY
  .      . ...  .   ...||| .|.||. .|. ....  .|..       . .|   .. ..| .|.  ..|  | ||  
reil.....nilkvvrds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsi
subfamily_CG42327_pd Subfamily CG42327 315-432 4.4e-19 63.3 In-house 37-147 (319) alignment 
Range on Protein: 315-432
Range on HMM: 37-147/319.0
MaapkrsdnfsfVAVDTNRIRLSITNDIPCSEYINASYIDSYNEAH-EYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPR----D
            | .   |. |    | . .||..|||.  |..|.  |||.|...|..  .||..||||.   || ||.|.. |      |.|     |
v...........vPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketld

GCVRYGKYIVTKIDEeELDDHTQ
.   ||.. ||  .  | .|.  
ntslyGdilvtlkgr.evkdrya
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 14-171 1.3e-18 61.5 In-house 89-238 (244) alignment 
Range on Protein: 14-171
Range on HMM: 89-238/244.0
EAAQTPYNKTKNRYPNILPYDHSRVVLraRKDSHGSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKlrsdcERYWPED
. |  | |  |||    ||.| .|| |   | | |  |||| ||   |   .|| .| ||..|  |||... |.    .|.||  | .     . |||. 
kdafnpnnswknregaglpfdfnrvpl..skgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpds

GHQEY--GDVAVSVVDVTHMTDWTVRTFLVWVRLHpecMDKREVTQFQFTAWPDQGVPEN
   |.   |..|.. |   . .     . .   .      .. .| || . || .|   |
eplewyeeditvtltdrdefknikasnleiesdmn...eshqaltmfqisnwpsdgttpn
0048076 (Phosphotyrosine protein) phosphatases II 431-542 1.5e-18 62.3 In-house 38-142 (145) alignment 
Range on Protein: 431-542
Range on HMM: 38-142/145.0
TQRSMDSLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKIQSTEdhGPTVVHCSDGAGRTGVFLALAISIErleaEDtVDIFQTVRWLRSQRPALVGSIE
. ..  . |.....| .|  || |. .. |  . |....... .  ||..|||| | ||||.. |. . ..    .. |.........|||||  | . .
selellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqrpgavpnpg

QYSCCYQAVKSY
|.  .|.... .
qlrflyefelel
subfamily_hpo-7_pd Subfamily hpo-7 73-251 3.6e-18 60.4 In-house 43-220 (263) alignment 
Range on Protein: 73-251
Range on HMM: 43-220/263.0
LTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCERYWP--EDGHQEYGDVAVSVVDVTHmtDWTVRTFLVWVRLHPeCMDKREVTQFQFTAWPDQGVPE
| .||. |.. |  .. ...|||.| . . . .|..|.|   |. | . .|.|.. .| .  |  ..|  .   |       ..|...... |...  ||
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlge.KkkthtvkhysykgWiekndpe

NTAP-LIIFHhkyryhLSSEEtGPILVHCGAGVGRTGTFIAIDSLMDQMMME------GVVDVYGFVAQMRTQRNFMVQTHEQYAFIY
..   | |..      .  .   .. ||| .|.||.  |  ....  .|..       . .|   .. ..| .|.  ..|  | ||  
lareilnilk......varns.kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsi
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 151-255 5e-18 59.9 In-house 213-341 (350) alignment 
Range on Protein: 151-255
Range on HMM: 213-341/350.0
DKREVTQFQFTAWPDQGV---PENTA------PLIIFHHKYRYHLSSEETGPILVHCGAGVGRTGTFIAIDSLMD-----QMMMEGV---------VD-V
|  .| |.|.  |.| ..   ||.        . .|     . || .... |||||| ||||||||....|||.      ... .            | .
dPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDli

YGFVAQMRTQRNFMVQTHEQYAFIYDVLR
   | ..| ||  |||. .|. |||. |.
siivnelrkqrismvqnldqfifiYeall
0048179 (Phosphotyrosine protein) phosphatases II 417-537 5.6e-18 60.5 In-house 32-139 (144) alignment 
Range on Protein: 417-537
Range on HMM: 32-139/144.0
YIVTKIDEEELDDHTQRsmdsllVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKIQSteDHGPTVVHCSDGAGRTGVFLALAISIerleaEDTVDIFQTVR
.... ..| | .. ..       ...... .|  || |. .. |  . | ......  ..||..|||| | ||||.. |. . .     .  ........
tvinlteeyepeflere......giqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk.....klglsleeala

WLRSQRPALVGSIEQYSCCYQ
..||.||  | . .|.  ...
lvrsrrpgavpnpgqlrfLle
subfamily_CG42327_pd Subfamily CG42327 472-542 5.8e-18 59.6 In-house 243-314 (319) alignment 
Range on Protein: 472-542
Range on HMM: 243-314/319.0
STEDHGPTVVHCSDGAGRTGVFLALAISIERLEAE-DTVDIFQTVRWLRSQRPALVGSIEQYSCCYQAVKSY
  |..|| |||||||.||||. .|  |.|..||    .||| |.|  .| .|   | ..|||   |. .  |
tresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 22-114 8.5e-17 55.5 In-house 49-157 (349) alignment 
Range on Protein: 22-114
Range on HMM: 49-157/349.0
KTKNRYPNILPYDHSRVVLRAR-------KDSH-------GSDYINANFVD--GYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSD
 .|||| .||||.||||.|.         | |.         ||||||..    .   .|||| | ||  |..||...|  .|   .. | | . .    
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslek

CERYWPEDG
|..|| |  
cdiywqels
subfamily_eak_pd Subfamily eak 319-462 1.1e-16 55.2 In-house 54-202 (332) alignment 
Range on Protein: 319-462
Range on HMM: 54-202/332.0
KRSdNFSFVAVDTNRIRLSITNDIPcSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRDG--CVRYGK
.|   .  |  | . .||. .   .   ||||| ..  .  ..|| | .. |. .  ||||| |||  |||.| |  . .  .|. |.| ..   ...|.
nrn.vvkivpydrylvrltssqlnr.lGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGi

YIVTK---IDEEELDDH---TQRSMDSLLVYHFQYHNWSAHGMPpRMNGLVF
. |..   . .. |.      ..  ..  |.|.... |.   .| ... .. 
ldverkefvkrniletrllelskGnethrvlhykvfGwtettlp.kyedfla
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 71-250 1.3e-16 55.0 In-house 98-280 (302) alignment 
Range on Protein: 71-250
Range on HMM: 98-280/302.0
GPLTETIKDFWRLIWEKGCTTIVMLGDTEHKLRSDCERYWPED--GHQEYGDVAVSVVDVT-HMTDWTVR-TFLVW-VRLHPEC---MDKREVTQFQFTA
 |  .|.. .| || .   . .| | .   .    |  |. ..  |. ..|  .|  |.|  .. ..| . .| .. | .. |      |. |  ..|.|
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPDQGVPENTAPLI-IFHHKYRYHLSseetgpILVHCGAGVGRTGTFIAIDSLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFI
||| | |... . . |...   |  .      .|||| ||||||||..||   ..  . . | |.   |  .|. |   ||...|  ..
wpdhGapkeaytaldilkfcesykkn......vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_CG42327_pd Subfamily CG42327 188-255 6.3e-16 52.9 In-house 244-312 (319) alignment 
Range on Protein: 188-255
Range on HMM: 244-312/319.0
SEETGPILVHCGAGVGRTGTFIAIDSLMDQMMME-GVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLR
 |. ||. |||  ||||||. || |  . ..      ||.   | ..| .|   |.| |||.||| || 
resqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvls
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 344-534 7.4e-16 53.1 In-house 45-250 (290) alignment 
Range on Protein: 344-534
Range on HMM: 45-250/290.0
CSEYINASYIdSYNEAHEYIATQAPMEN-------TINEFWQMVWEQKCTAIVMLTELQDRGQIESE----LYWPR--DGCVRYGKYIVTKIDEEELDDH
 ..|| |... .. .  . |.||.| |.       ||..|| |. . | . .||| | ... .  |.     | |   .. ....   |   . |. || 
nddyiHAnrv.tcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddv

TQRSM-------DSLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQkiqstEDHGPTVVHCSDGAGRTGVFLALAISIERLE-AEDTVDIFQTVRWLRSQR
 .| .         . | | ....|.   ...    |. | ..|.       . | .||| ||  |  .. |. ..   .   .. | . . .  ||.||
etRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk.....asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqr

PALVGSIEQYSC
  .. | .... 
alaitsalelaf
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 436-541 1.4e-15 51.6 In-house 87-192 (440) alignment 
Range on Protein: 436-541
Range on HMM: 87-192/440.0
DSLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKIQSTEDHGPTVVHCSDGAGRTGVFLALAISIERLEAEDTVDIFQTVRWLRSQRPALVGSIEQYSCC
.|  . ...|. |  .|.|     .. . ..|.. |     || .|||| ||||||| .|.   .   .  | .|||  .  .|..|| .| . |||.  
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

YQAVKS
..||  
heavle
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 196-257 2.3e-15 50.7 In-house 2-63 (69) alignment 
Range on Protein: 196-257
Range on HMM: 2-63/69.0
VHCGAGVGRTGTFIAIDSLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLRDA
||| .| |||||||||   | ..  | .||..  |  ||  |  ||   ..| ||.| | .|
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvea
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 345-544 2.9e-15 50.8 In-house 67-277 (312) alignment 
Range on Protein: 345-544
Range on HMM: 67-277/312.0
SEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPR-DGCVR------YGKYI-VTKIDEEELDDHTQRSMD
  || | ..        ...||.|.|||.  |||..    .|.|..|. . . |  ..  |     | |       | .|    .|     |  |.| . 
nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlk

SLL--------VYHFQYHNWSAHGMPPRMNGLVFLHEQVQKiqsteDHGPTVVHCSDGAGRTGVFLALAISIERLEAEDTVDIFQTVRWLRSQRPALVGS
 ..        . |.|.  |  ||||   .    |   |.|     |. | . ||| | |||| .  .   |  |      .. ..   || .|   |  
vvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkk.....dkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrv

IEQYSCCYQAVKSYLS
. ||  . ..|  .| 
fpqyvyalrcvlefly
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 195-257 3.3e-15 50.2 In-house 2-64 (69) alignment 
Range on Protein: 195-257
Range on HMM: 2-64/69.0
LVHCGAGVGRTGTFIAIDSLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLRDA
.||| .| |||||||||   | ..  | .||..  |  ||  |  ||    .| ||.| | .|
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvea
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 19-257 3.6e-15 50.4 In-house 45-278 (303) alignment 
Range on Protein: 19-257
Range on HMM: 45-278/303.0
PYNKTKNRYPNILPYDHSRVVLrarKDshgSDYINANFVDgYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTT-IVMLGDTEHKLRSDcERYWP-EDGHQ
  |  |||. ...  |||.| |    |   | || |....   . .| | .| ||. |  |||..| |.     ...| |.|..     .  .| ..   
vknmdknrfvdvicldhskvkl...sd...ssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklgg.dsvfprnqdfl

EYGDVAVSVVDV---THMTDWTVRTFLVwvrlhPECMDKREVTQFQFTAWPDQGVPENTAPLII---FHHKYRYHLSSeETGPILVHCGAGVGRTGTFIA
.. . .. | .      .  |...   |      .   |  .   .. ||| . .| ...| ..   .  .      | .. | .    .|.||.|||  
kfeersirvgefkrvelgdgwvlkvlsv.....sngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkys.dstptvymslsgcgragtfal

IDSL-MDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLRDA
...  .     .  .|.   . ..|  |   ||   |....| .| . 
fetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaeh
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 340-410 5.4e-15 49.9 In-house 83-154 (350) alignment 
Range on Protein: 340-410
Range on HMM: 83-154/350.0
NDipcseYINASYIDSY------NEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRDG
||     ||||.|.         |  . |||||||. .|...|.... . | . |..||.... .    . ||.. .
nD.....YinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqegs
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 10-71 8.9e-15 48.7 In-house 37-95 (95) alignment 
Range on Protein: 10-71
Range on HMM: 37-95/95.0
RATFEAAQTPYNKTKNRYPNILPYDHSRVVLRARKDshgSDYINANFVDGYGCPQKYIAAQG
 |.. .  .  |  |||. ||.||| .|||| ...|   |||||| |||||   . ||||||
gapytvgsseanipknrflnifpydatrvvlttkrd...sdyinacfvdgyarkncyiaaqg
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 480-536 1.3e-13 45.2 In-house 2-58 (69) alignment 
Range on Protein: 480-536
Range on HMM: 2-58/69.0
VVHCSDGAGRTGVFLALAISIERLEAEDTVDIFQTVRWLRSQRPALVGSIEQYSCCY
||||| |.|||| |.|. . . |. .|  ||||  |...|  || .|    .|   .
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifih
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 480-538 1.7e-13 44.7 In-house 1-59 (69) alignment 
Range on Protein: 480-538
Range on HMM: 1-59/69.0
VVHCSDGAGRTGVFLALAISIERLEAEDTVDIFQTVRWLRSQRPALVGSIEQYSCCYQA
||||| |.|||| |.|. . . |. .|  ||||  |...|  || .|   ..|   ..|
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihda
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 192-253 2.5e-13 44.5 In-house 229-290 (297) alignment 
Range on Protein: 192-253
Range on HMM: 229-290/297.0
GPILVHCGAGVGRTGTFIAIDSLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDV
 ..|||| |||||.|  .  | .....  . . ||  .. ..| ||  .||| ||. ..||.
ayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellyda
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 328-407 5.9e-13 43.2 In-house 59-135 (305) alignment 
Range on Protein: 328-407
Range on HMM: 59-135/305.0
AVDTNRIRLsiTNDIPcSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWP
 .| ||..|   .  |  ||| | |. .  ... .| ||||.|.|  .|| | ...|  || || .|...|      |..
cldnnrvkl..egpwp.heyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfa
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 431-546 1.8e-12 41.7 In-house 208-347 (350) alignment 
Range on Protein: 431-546
Range on HMM: 208-347/350.0
TQRSMDSLLVYHFQYHNWSAHGMPPRMNGLVFLHE--------QVQKIQS-TEDHGPTVVHCSDGAGRTGVFLALAISIE---RLE-----------AED
|  . | . ||..|..||   ..  . . ..   |         . .  . ..   | .|||| | ||||....|   ..    ||           |  
tlaasdPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaak

TVD-IFQTVRWLRSQRPALVGSIEQYSCCYQAVKSYLSWR
| | |...|  ||.||  .| ...|.  .|.|.. | . |
trDlisiivnelrkqrismvqnldqfifiYeallfyfaLr
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 327-539 3.3e-12 40.6 In-house 57-275 (303) alignment 
Range on Protein: 327-539
Range on HMM: 57-275/303.0
VAVDTNRIRLSitnDipcSEYINASYIDsYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRD--------GCVRYGKYI
. .|  ...||   |   | || |||..  .  .  | || |.  |  .||||. |||   ...|    .  ..  .  .||.          .| |.. 
icldhskvkls...d...ssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersirvgefk

VTKIDEE-ELDDH--TQRSMDSLLVYHfQYHNWSAHGMPPrmNGLVFLHEQVQKIQS----TEDHGPTVVHCSDGAGRTGVFLALAISIERLEAE-DTVD
  .. .   |     .. .  |.|  | .|..|    .|   .|   .  |. ..||      |  |||     | ||.| |  .  .   | .|  ..|
rvelgdgwvlkvlsvsngdyksflhvh.hykawphnsips..dgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseqasld

IFQTVRWLRSQRPALVGSIEQYSCCYQAV
. . .  .|  |   |  . |.|  |  .
lvkclenvrngrlhavqnlsqfsvvytll
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 21-102 3.8e-12 40.3 In-house 34-114 (332) alignment 
Range on Protein: 21-102
Range on HMM: 34-114/332.0
NKTKNRYPNILPYDHSRVVLrARKDSHgSDYINANFVDGYGCPQKYIAAQGPLTET-IKDFWRLIWEKGCTTIVMLGDTEHKL
|   || | .  .||||| | | .| .  |. ||..||||     || || |. .     |||.. |.  . |...|| . | 
nmdmnriphlycfdhsrvel.apqdgk.ddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekq
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 154-254 4.6e-12 39.9 In-house 219-340 (349) alignment 
Range on Protein: 154-254
Range on HMM: 219-340/349.0
EVTQFQFTAWPDQGVPENT---------APLIIFHHKYRYHLSSEETGPILVHCGAGVGRTGTFIAIDSLMD--QMMMEGVV---------D-VYGFVAQ
|. |.|.  |.| ..  |           . .|     | .| .... ..|||| || ||||... .|.|..  ... .  .         | ..  | .
ellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivne

MRTQRNFMVQTHEQYAFIYDVL
.| ||  |||   |. .||. |
lrkqrismvqnlaqfiaiyeal
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 319-401 5.6e-12 39.8 In-house 47-126 (347) alignment 
Range on Protein: 319-401
Range on HMM: 47-126/347.0
KRSDNFSFVAVdTNRIRLSITNDipCSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIE
|  |.   |    .. . | ..|     |||||.|   |  .||| || |. .|. .||.||   | | .| . | .    ||
klidatrvvls.peksknsradd..vetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikdeaie
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 17-174 6.9e-12 38.6 In-house 23-160 (169) alignment 
Range on Protein: 17-174
Range on HMM: 23-160/169.0
QTPYNKTKNRYPNILPYDHSRVVLRARKDSHGSDYINAnfvdgygcpqkyiaaqgpltetikdfwRLIWEKGCTTIVMLGDTEHKlrsdcERYWPEDGH-
.   |.||||    |   | || |.   .  |||||||                           |.|||   . ||.||||. |     . .|||    
eltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddk.....nnfwpekedy

Q---------EYGDVAVSVVDVTHMT-DWTVRTFLVWVRLHPECMDKR-EVTQFQFTAWPDQGVPENTAP
|          | |      |  |.  .     | | . .|    |   ... .....||..|||..   
qlhpavilgewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqspvh
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 17-172 9.5e-12 38.1 In-house 22-157 (169) alignment 
Range on Protein: 17-172
Range on HMM: 22-157/169.0
QTPYNKTKNRYPNILPYDHSRVVLRARKDSHGSDYINAnfvdgygcpqkyiaaqgpltetikdfwRLIWEKGCTTIVMLGDTEHKlrsdcERYWPEDGHQ
.   |.||||    |   | || |.   .  |||||||                           |.|||   . ||.||||. |     . .|||    
eltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddk.....nnfwpekedy

-E---------YGDVAVSVVDVTH-MTDWTVRTFLVWVRLHPEcmdKREVTQ----FQFTAWPDQGVPENT
           | |      |  |  |      | | . .|     ...||.    .....||..|||.. 
qlhpavilGewytdslyvrtdkvhpntsgveglfevslvihsy...dddvteqlsllhystwpqngvpqsp
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 31-169 1e-11 39.3 In-house 3-127 (130) alignment 
Range on Protein: 31-169
Range on HMM: 3-127/130.0
LPYDHSRVVlrarkdshGSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKlrsdcERYWPEDGHQEYG--DVAVSVVDV
|... ||.         | .||||.||   |  ..|. .| ||..|  |||... |.    .|.||  | .     . |||.    |.   |. |.. | 
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdr

THMTDWTVrtflVWVRLHPECMD-KREVTQFQFTAWPDQGVP
  .           .. . . .. .. .| || . || .|  
defknika....snleiesdlneshqaltmfqisnwpsdgtt
subfamily_eak_pd Subfamily eak 24-170 1.4e-11 38.4 In-house 55-196 (332) alignment 
Range on Protein: 24-170
Range on HMM: 55-196/332.0
KNrYPNILPYDHSRVVLRARKDShGSDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGD-TEHKLRsDCERYWPEDG--HQEYGD
.|   .|.|||.  | | . .      ||||  ..     .||| .  .  . .  ||... |.   .||.| .  | ||    ..|.|...    ..| 
rn.vvkivpydrylvrltssqln.rlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkle.ksdkyfpdktreelkfGi

VAVSVVDVTHMTDWTVRTFLVWVrlhpeCMDKREVTQFQFTAWPDQGVPE
. |   .  .     .| . . .       .  .|  ...  | .  .| 
ldverkefvkrniletrllelsk.....GnethrvlhykvfGwtettlpk
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 327-414 5e-11 36.7 In-house 106-186 (244) alignment 
Range on Protein: 327-414
Range on HMM: 106-186/244.0
VAVDTNRIRLSITNdiPCSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQdrgqiESELYWPRDGCVRY
. .| ||. ||  .      |||||..     . ||| || |. .|  .||.|. |..   .|.|  ..     | . |||    . .
lpfdfnrvplskgs..mgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsve.....eedeywpdseplew
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 14-60 1.5e-10 35.0 In-house 40-86 (440) alignment 
Range on Protein: 14-60
Range on HMM: 40-86/440.0
EAAQTPYNKTKNRYPNILPYDHSRVVLRARKDSHGSDYINANFVDGY
. |  | || |||| ||| ||||||.|   |    |||||| ...| 
diaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 372-523 3.1e-10 34.6 In-house 40-201 (255) alignment 
Range on Protein: 372-523
Range on HMM: 40-201/255.0
TINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWP--RDGCVRYGKYIVTKIDeeELDDH---TQRSM-------DSLLVYHFQYHNWSAHGMPPRMNG
|...|.|..  .| . .|||..... |. . . |.|  .|.  .. .  ||  .     |    | . .           | |..|. | ..  |   . 
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

LVFLHEQVQKIQstedhgPTVVHCSDGAGRTGVFLALAIS----IERLEAEDTVDI--FQTVRWLRSQRP
. ..   |.. .      . ||||| | ||.  |    .     |  |.  .||..   . .. |||.|.
ilnilkvvrdsk......svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrk
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 340-429 4.2e-10 34.0 In-house 8-94 (130) alignment 
Range on Protein: 340-429
Range on HMM: 8-94/130.0
NDIPCSEYINASYIDSYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQdrgqiESELYWPRDGCVR-YG-KYIVTKIDEEELDD
. ..  .|||||..   . . ||. ||.|. .|  .||.|. |.    .|.|  ..     | . |||    .  |  . |||  | .| . 
srlqgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsve.....eedeywpdsePlewyeediivtltdrdefkn
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 329-546 4.5e-10 32.7 In-house 75-312 (346) alignment 
Range on Protein: 329-546
Range on HMM: 75-312/346.0
VDTNRIRLSIT---------NDIPCSEYINASYIDSYNEAHEYIATQAP-MEN--TINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWPRDGCVRY-G
 | | |  |.            .|.  ..   |.  ..  |. | .| | |||   ...|| |.....   . ..   .   .  . |.   .|  .| |
edvnyinasvitlkdvsrrmacvpayvhlvvlyfvifqfehklivaqlpqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytg

KYIVTKID--------EEELDDHTQRSMDSLLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQKIQSTEDHGPTVVHCsDGAGRTGVFLALAISIERLEAED
| .. .          |  ..   .   ||...   ..  |     ||.   .. .  |    .  .. |  ||    |.||.  |.    .|..|.   
kmfinnrradvsgdpkeytievlpegnsdsvicqvhhhapwkhlqqppktlpiikmihqflsekqvqnagvcvvsl.fgcgracsfigalyainqlnngi

TVDIFQTVRWLRSQRPALVGSIEQYSCCYQAVKSYLSWR
  .|.. .. .. |||  | |. ||.  |  |  |.. .
epniceimknikqqrpggvesfaqyasiyaivfdyiark
0038934 (Phosphotyrosine protein) phosphatases II 150-250 6e-10 34.6 In-house 70-176 (194) alignment 
Range on Protein: 150-250
Range on HMM: 70-176/194.0
MDKREVTQ----FQFTAWPDQGVPENTAPLIIFHHKYRYHLSSEETGPILVHCGAGVGRTGTFIAIdSLMDQMMMeGVVDVYGFVAQMRT----QRNFMV
 |..|...    .    .||.|.. ... |  | .    .|.  . | ..||| ||.|||||..|   |.  . |  . . .......|     ..... 
YdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa.YLiyrlgm.saeeAialfrekRpgaipnqdyle

QTHEQYAFI
. .. | ..
allkrykel
0038934 (Phosphotyrosine protein) phosphatases II 442-537 1.2e-09 33.5 In-house 79-171 (194) alignment 
Range on Protein: 442-537
Range on HMM: 79-171/194.0
HFQYHNWSA--HGMPPRMNGLVFLHEQVQKIQSTEDHGPTVVHCSDGAGRTGVFLALAISI-ERLEAEDTVDIFQTVRwlrsqrPALVGSIEQYSCCYQ
 ..|...    .| .| .. |    . |... .   .|  .|||  | ||||...| ..    .. ||. ...|. .|      |  . ......  ..
gieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekR......pgaipnqdyleallk
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 438-544 1.3e-09 32.2 In-house 186-288 (305) alignment 
Range on Protein: 438-544
Range on HMM: 186-288/305.0
LLVYHFQYHNWSAHGMPPRMNGLVFLHEQVQkiqstEDHGPTVVHCSDGAGRTGVFLALAISIERLEAEDTVDIF-QTVRWLRSQRPALVGSIEQYSCCY
. | |. . .|   |.|.  . .. | |. .       .||.||||| | ||||  . |   ...| | . ..   . .. .| ||   . . .||   .
rkvthyhwidwpdrgvpaadlailellekar.....pskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvh

QAVKSYLS
| .  |. 
qvilnyfr
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 355-428 2.4e-09 31.0 In-house 231-302 (440) alignment 
Range on Protein: 355-428
Range on HMM: 231-302/440.0
SYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGqieSELYWPRDG-CVRYGKYIVTKIDEEELD
 |     .|||| |.. |. .||..| . . ..|.|| .|.|.      .||| .   | .| . | .   |...
gyskknafiatqmpldstvldfwrlvhdyristiimlnqlndkt...csiywpvntrsvtfgpftvghkgsenmn
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 344-407 2.6e-09 30.8 In-house 89-154 (349) alignment 
Range on Protein: 344-407
Range on HMM: 89-154/349.0
CSEYINASYID--SYNEAHEYIATQAPMENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWP
  .|||| |.    ..  . |||||||.  |...|....  ..   .. |.. .. .    . || 
lddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywq
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 58-138 8.2e-09 29.3 In-house 230-308 (440) alignment 
Range on Protein: 58-138
Range on HMM: 230-308/440.0
DGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVMLGDTEHKlrsDCERYWPEDGH-QEYGDVAVSVVDVTHMTDWTVRT
.||   . .||.| ||  |. |||||. .   .||.|| . . |    |  ||| .     .|  .|       |    |||
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpftvghkgsenmnrvkvrt
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 425-546 1.8e-08 28.1 In-house 202-347 (349) alignment 
Range on Protein: 425-546
Range on HMM: 202-347/349.0
EELDDHTQRSMDS---LLVYHFQYHNWSAHGMppRMNGLVFLH-----------EQVQKIQSTEDHGPTVVHCSDGAGRTGVFLALAISIE--RLEAED-
.. ||...  ...     .. .|. ||   ..   .|   .|.              ..   |..  . .|||| | |||||.  | . ..      .. 
pddddddaillavekPyellqlqvknwldlsl..llnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnes

---------TVDIFQTVRWLRSQRPALVGSIEQYSCCYQAVKSYLSWR
            |. .|  || || ..|  . |.  .|.|.  |.. .
nkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyfalk
subfamily_hpo-7_pd Subfamily hpo-7 370-522 7.2e-08 26.6 In-house 44-206 (263) alignment 
Range on Protein: 370-522
Range on HMM: 44-206/263.0
ENTINEFWQMVWEQKCTAIVMLTELQDRGQIESELYWP--RDGCVRYGKYIVTKIDEEEldDHTQRSMDSLL----------VYHFQYHNWSAHGMPPRM
 .||..|.|..  .| . .|||.. .. |. . . |.|  .|.  .. .  |.  .  .  |   .. . |           | |..|  | ..  |  .
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpela

NGLVflheqvQKIQSTEDHGPTVVHCSDGAGRTGVFLALAIS----IERLEAEDTVDI--FQTVRWLRSQR
.  .      . .. . .  . ||||| | ||.  |    .     |  |.  .||..   . .. |||.|
reil......nilkvarnskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssr
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 20-95 7.6e-08 26.3 In-house 36-116 (347) alignment 
Range on Protein: 20-95
Range on HMM: 36-116/347.0
YNKTKNRYPNILPYDHSRVVLRARKDSHG-----SDYINANFVDGYGCPQKYIAAQGPLTETIKDFWRLIWEKGCTTIVML
 . .|||  .    | .||||   |   .       ||||  .    . ..|| .| || .|..|||...     | .| .
kslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 330-397 1.3e-07 25.4 In-house 47-113 (332) alignment 
Range on Protein: 330-397
Range on HMM: 47-113/332.0
DTNRIRLSITNdiPCSEYINASYIDSYNEAHEYIATQAPMEN-TINEFWQMVWEQKCTAIVMLTELQDR
| .|. |.  .     .. |||..| |..   || .|||... |   ||.|| |.| . |... .....
dhsrvelapqd..gkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidek
subfamily_PTPDC1_pd Subfamily PTPDC1 147-251 1.7e-07 25.9 In-house 75-169 (182) alignment 
Range on Protein: 147-251
Range on HMM: 75-169/182.0
PECMDKREVTQFQFtAWPDQGVPENTAPLIIFHHkyryHLSSEETGPILVHCGAGVGRTGTFIAIdslmdQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQ
.| . ..... ..| .|.| ||.  .  | |         .. . | . ||| || ||||  ||       ..    ..    .  .| .|   .||.||
lealmeqgiyvynf.gwkDygvasleriLdivkv....vafalqegkvavhChaGlGrtGvliac.....ylvyakrltaekaiklvrskrpksiqtreq

YAFIY
  .. 
velvk
subfamily_PTEN_pd Subfamily PTEN 179-250 3.1e-07 25.5 In-house 102-172 (184) alignment 
Range on Protein: 179-250
Range on HMM: 102-172/184.0
HHKYRYHLSSEETGPILVHCGAGVGRTGTFIAIdSLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFI
 .. . .|.....  . ||| || ||||. |.   |. ....|   ..  . |..||. .  |.   |  ..
vediekwleedkknvvvvHCkaGkGRtGvliva.yllkslllekaeealelfaeaRtknkkgvtiPsqrRYv
PTPc_motif_SM00404 187-236 3.6e-07 25.2 In-house 76-123 (140) alignment 
Range on Protein: 187-236
Range on HMM: 76-123/140.0
SSEETGPILVHCGAGVGRTGTFIAIdSLMDQMMMEgVVDVYGFVAQMRTQ
. .. | .|||| ||| |..|.|.   ||... .. . ..| || . | .
aekkggkvlVHCqaGvSRSatliia.Ylmryrqls.laeayefvkerRpi
subfamily_PTPDC1_pd Subfamily PTPDC1 463-539 4.2e-07 24.6 In-house 101-172 (182) alignment 
Range on Protein: 463-539
Range on HMM: 101-172/182.0
LHEQVQKIQSTEDHGPTVVHCSDGAGRTGVFLALA-ISIERLEAEdtvdifQTVRWLRSQRPALVGSIEQYSCCYQAV
. . |. .... ..| . |||  | ||||| .|   .  .||.||      .... .||.||  . . ||  .. .  
iLdivkvvafalqegkvavhChaGlGrtGvliacylvyakrltae......kaiklvrskrpksiqtreqvelvkefa
PTEN_1 166-247 4.9e-07 24.7 In-house 100-184 (196) alignment 
Range on Protein: 166-247
Range on HMM: 100-184/196.0
QGVPENTAPLIIFHHKYRYHLSSE-----ETGPILVHCGAGVGRTGTFIAIdSLMDQMMmEGVVDVYGFVAQMRTQRNFMVQTHEQY
 ...  .|| . ....  . . .      . . .|||| ||.||.|| .|   ||  .    . .   .|...|.....    .|..
fpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaa.yLmykgk.ltadeAlelvrekRppgapnspsqerl
subfamily_eak_pd Subfamily eak 183-254 6.6e-07 23.0 In-house 229-301 (332) alignment 
Range on Protein: 183-254
Range on HMM: 229-301/332.0
RYHLSSEETGPIlVHCGAGVGRTGTFIAIDSLMDqMMME---GVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVL
.|. .     || . .  |  |.|.|. || |.  .. .    .  |  .. .....|.  | .  |..|||...
kyihtppsfapi.iqsarGsaraGvfvvidllir.lidnkkknlysvedlilkvkskrihsvlvalqhsfiyeiv
subfamily_ptpA1_pd Subfamily ptpA1 441-504 7.3e-07 23.2 In-house 189-257 (418) alignment 
Range on Protein: 441-504
Range on HMM: 189-257/418.0
YHFQYHNWSAHGMPPRMNGLVF-----LHEQVQKIQSTEDHGPTVVHCSDGAGRTGVFLALAISIERLE
 ..||  |  | .| . . .          | | | |..   | .|||| | |||| | .  | ...|.
tqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkld
PTEN_1 468-522 7.9e-07 24.1 In-house 122-177 (196) alignment 
Range on Protein: 468-522
Range on HMM: 122-177/196.0
QKIQSTEDHGPTVVHCSDGAGRTG-VFLALAISIERLEAEDTVDIFQTVRWLRSQR
. ..| ....  .|||  | ||.| |  |. .. ..| |........  |. .. .
ewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapn
subfamily_CDC14_pd Subfamily CDC14 143-244 1.4e-06 22.3 In-house 217-311 (328) alignment 
Range on Protein: 143-244
Range on HMM: 217-311/328.0
VRLHPECMDKREVTQFQFTaWPDQGVPENTAPLIIFHHKYrYHLSSEETGPILVHCGAGVGRTGTFIAIdSLMDQMMMEgvvdVYGFVAQMRTQRNFMVQ
|||  .  |... |.  |    |.   . . |     .|.  ... . .| | ||| ||.|||||.||   || .  .         .| .|  |  .| 
vrLnkklYdakkftdaGfd.hkDlffiDGstPsdaivkkf.leiaekaeGaiavhCkaGLGrtGtLiac.ylmkhyrft....aaeaiawlricrPGsvi

TH
..
gp
DSPc Dual specificity phosphatase, catalytic domain 189-236 1.5e-06 23.1 Pfam-A 71-116 (133) alignment 
Range on Protein: 189-236
Range on HMM: 71-116/133.0
EETGPILVHCGAGVGRTGTFIaIDSLMDQMMMeGVVDVYGFVAQMRTQ
.. . .|||| ||. |..|.| |  ||... .  . . | || . | .
qkgkkvlVHCqaGisRSatli.iaYlmktknl.slneAyefvkerrsk
DSPc Dual specificity phosphatase, catalytic domain 189-236 1.5e-06 23.1 In-house 71-116 (133) alignment 
Range on Protein: 189-236
Range on HMM: 71-116/133.0
EETGPILVHCGAGVGRTGTFIaIDSLMDQMMMeGVVDVYGFVAQMRTQ
.. . .|||| ||. |..|.| |  ||... .  . . | || . | .
qkgkkvlVHCqaGisRSatli.iaYlmktknl.slneAyefvkerrsk
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 64-256 3.4e-06 19.9 In-house 115-307 (346) alignment 
Range on Protein: 64-256
Range on HMM: 115-307/346.0
QKYIAAQGPLTE---TIKDFWRLIWEKGCTtIVMLGDTEHKLRSDCER-YWPEDGH-QEYGDVAVSVVDVTHMTDWTVRTflvwVRLHPECMDKREVTQF
.| | || |  |    ..||| .|...    .| |   . ||.      .  |.|  |  | . .         |    |    . . ||      . | 
hklivaqlpqmenesfvedfwymiyqeqih.lvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeyt....ievlpegnsdsvicqv

QF-TAWPDQGVPENTAPLIIFHHKYRYHLSSEETGPILVhCGAGVGRTGTFIAIDSLMDQMMMEGVVDVYGFVAQMRTQRNFMVQTHEQYAFIYDVLRD
.  . |     | .| |.| . |..      ...|  .|    | ||. .||     ..|.      ...  . ... ||   |..  ||| || .. |
hhhapwkhlqqppktlpiikmihqflsekqvqnagvcvv.slfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfd
0048567 (Phosphotyrosine protein) phosphatases II 162-211 5e-06 21.0 In-house 44-97 (157) alignment 
Range on Protein: 162-211
Range on HMM: 44-97/157.0
AWPDQGvPENTAPLIIFHHKYRYHLS--SEETGPILVHCGAGV---GRTGTFIAI
 . | | | | | |. | .|    |.  ... ..| ||| ||    |||.|.|. 
fffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigc
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 445-526 6.5e-06 19.8 In-house 195-271 (302) alignment 
Range on Protein: 445-526
Range on HMM: 195-271/302.0
YHNWSAHGMPPRMnglvflHEQVQKIQSTEDHG-PTVVHCSDGAGRTGVFLALAISIERLEAEDTVDIFQTVRWLRSQRPALV
.  |  || |         .  .. ..  | .    .|||| | |||| ..|.   |.    ... |. . |  .|. |   |
fsawpdhGapkea......ytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGav
subfamily_DSP10_pd Subfamily DSP10 191-235 8.9e-06 19.7 In-house 92-134 (159) alignment 
Range on Protein: 191-235
Range on HMM: 92-134/159.0
TGPILVHCGAGVGRTGTfIAIDSLMDQMMMEgVVDVYGFVAQMRT
   .|||| ||. |  | ..|  || .. .  . | | || . |.
gsrvLvhCqaGisrsat.vviaYlmkhlnls.lndaykfvkekrp