Gene NvecPTP-Un-3 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP070_AA protein Get Run
NvecP070_AA_24-167 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 19-168 1.5e-74 246.7 In-house 2-152 (564) alignment 
Range on Protein: 19-168
Range on HMM: 2-152/564.0
HPPVPVDNFAKHVHKLHKSDDRGFMIEYNKLDAGREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIP
..|.||.....||.||....|  |. ||.|.. |..|....| .. ||||||| ||||||||||||...|.. ||||||||.||||.|..||||||||..
skpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPla

TTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDE-TEEYGDIGVQL
.|..|||||||||.|..|||||.|.|..| |||||||.. ||.||.. |.|
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtl
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 22-167 4.9e-60 198.2 In-house 2-149 (318) alignment 
Range on Protein: 22-167
Range on HMM: 2-149/318.0
VPVDNFAKHVHKLHKSDDRGFMIEYNKLDAGRE-FPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTT
..|.....||..|..| .  .  ||..|.  .| .    . .. ||||||| ||.||||.|| |...|.. |||||||..||||.. .||||.|.|.| |
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

FDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDE-TEEYGDIGVQ
..|||||||||.|| |||||...|| | |.|.|||.. ...||.. |.
ieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvve
subfamily_PTPRG_pd Subfamily PTPRG 22-168 8.7e-59 194.2 In-house 1-152 (563) alignment 
Range on Protein: 22-168
Range on HMM: 1-152/563.0
VPVDNFAKHVHKLHKSDDRGFMIEYNK---LDAGREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGS-DYINASHIDGYNKPNAYIATQGPI
|||..||||| .|| ..| ||  |...     . ...... . . .|| |||| ||||||.||| |... .. .. |||||..||||.| .|.||||||.
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

PTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWP-DETEEYGDIGVQL
..||||||||.|||..| |||.|||.||.. ||. ||| ||.|.|| . |.|
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtl
subfamily_PTPRB_pd Subfamily PTPRB 20-168 2.8e-57 189.0 In-house 5-156 (293) alignment 
Range on Protein: 20-168
Range on HMM: 5-156/293.0
PPVPVDNFAKHVHKLHKSDDRGFMIEYNKLDA-GREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIP
 |. ...|..||.|... .| .|. ||..| | |..  ...| .. |.||||| ||..|||||| |..... .|||||||..|.||| |. .||||||.|
kpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlp

TTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDE--TEEYGDIGVQL
.|.|||||||||..|  |||||.| |. | ||..|||..  .  |||| |.|
etvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 21-167 1.2e-55 183.8 In-house 4-151 (319) alignment 
Range on Protein: 21-167
Range on HMM: 4-151/319.0
PVPVDNFAKHVHKLHKSDDRGFMIEYNKLDAGREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTT
...|.........|... ....  |...|. . ..  | | . .|| |||| ||.|||..|||| |...| ||||||||.||||.. ...||||.|. .|
eievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlent

FDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDET-EEYGDIGVQ
..||||||||..|  .||||.|.|. |.|..||||.|. |||| . |.
iedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivt
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 26-168 1.1e-54 180.7 In-house 13-160 (298) alignment 
Range on Protein: 26-168
Range on HMM: 13-160/298.0
NFAKHVHKLHKSDDRGFMIEYNKLDAGRE----FPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTTF
 . | . . .| .  |.  |...|... .    .  .|| ...|| |||| .|.|.|.|||||.....   |||||||....|.. ||.||||.|...|.
alqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetv

DDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPD-ETEEYGDIGVQL
 ||||||.|.....|||||||.| .|.|.|||||| ..|.||.| |.|
edFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsl
0051299 (Phosphotyrosine protein) phosphatases II 19-166 1.8e-54 180.5 In-house 2-151 (288) alignment 
Range on Protein: 19-166
Range on HMM: 2-151/288.0
HPPVPVDNFAKHVHKLHKSDDRGFMIEYNKLDAGR-EFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPI
. ...|....|.|.||....  |.. |...| .    ... .|.   |. |||| .|..||||||.|. ...| ||||||||.|||||.....|||||| 
dteisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPl

PTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWP-DETEEYGDIGV
|.|..|||||||||..  |||||.|.|. . ||..||| .....|||| |
pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditv
subfamily_PTPRA_pd Subfamily PTPRA 18-167 1.3e-53 177.0 In-house 10-161 (330) alignment 
Range on Protein: 18-167
Range on HMM: 10-161/330.0
EHPPVPVDNFAKHVHKLHKSDDRGFMIEYNKLDAG-REFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGP
...|.||... . ...    | . |  |.| | ||  .  ...| . .|| |||. ||. ||.|||.|...| |  |||||||.||||.. . .||.|||
kyfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGP

IPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDET-EEYGDIGVQ
   | .|||||.|||.||.|||||.|.||.. ||..|||||    ||.| |.
keetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirve
subfamily_PTPRK_pd Subfamily PTPRK 19-168 2.5e-53 175.9 In-house 1-146 (314) alignment 
Range on Protein: 19-168
Range on HMM: 1-146/314.0
HPPVPVDNFAKHVHKLHKSDDRGFMIEYNKLDAGrefpCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIP
|| . |..  ... .|....  ||  ||. |  |     |.| . .|..|||.|.|.|||.|||.|  |..   ||||||. ||.|..|.|.|.||||..
hpairvadllqsiallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlq

TTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDETEEYGDIGVQL
 |  ||||.|.....|||||||.|.|  ..|| ||||..|| |||| |.|
etvkdfWrlvydencasivmltelvevgrvkClkyWPedtevygdikvel
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 28-166 3.7e-53 175.5 In-house 3-144 (281) alignment 
Range on Protein: 28-166
Range on HMM: 3-144/281.0
AKHVHKLHKSDDRGFMIEYNKLDA-GREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTTFDDFWR
 ||...|...|..||. ||.|| | |.. .   ... .|. |||| ||||||..||.... |.   .|||||....||.....|||||||.|.....||.
rkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWq

MVWEQQSASIVMLTNLQERHKLKCHKYWPDET--EEYGDIGV
|||||.   |||.|.  |  |||||.||||..   .|||. |
mvweqkvsaivmvtreieagklkChrYWPddnselkygdvtv
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 19-166 1.9e-52 173.2 In-house 3-150 (315) alignment 
Range on Protein: 19-166
Range on HMM: 3-150/315.0
HPPVPVDNFAKHVHKLHKSDDRGFMIEYNKLDAGREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIP
| |.|.|..  .| . . |   ||  .|. .  |. .| ||| .. || |||| ||.|||.||| |  .||  .|||.||. ||||||.. |||.||| .
hqpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnv

TTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDETEEYGDIGV
.. .||||.|.|.. . ||||||| |..| |. |||||.   || | |
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviyGkitv
0043336 (Phosphotyrosine protein) phosphatases II 21-166 7.4e-52 171.9 In-house 1-146 (278) alignment 
Range on Protein: 21-166
Range on HMM: 1-146/278.0
PVPVDNFAKHVHKLHKSDDRGFMIEYNKLDAGREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTT
|..| ...|.. .|.... .... |. .|.    .....|.  .|| |||| .|..||||||.|. .... .|||||||..||||.|...|||||| | |
pisvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpet

FDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDETEEYGDIGV
..||||||||... .|||||.| |... ||..|||.....|||. |
vedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftv
0040438 (Phosphotyrosine protein) phosphatases II 25-166 4.3e-51 169.4 In-house 3-145 (317) alignment 
Range on Protein: 25-166
Range on HMM: 3-145/317.0
DNFAKHVHKLHKSDDRGFMIEYNKLDAGREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTTFDDF
 .. ... .|.||| .... |...|.     ...||.  .|| |||| .|. ||||||.|. .... .|||||||..||.|.....|||||| | |..||
ldlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedF

WRMVWEQQSASIVMLTNLQERHKLKCHKYWP-DETEEYGDIGV
|||||||.. .|||||.| |. . ||..||| .|| .|||. |
wrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftv
0050432 (Phosphotyrosine protein) phosphatases II 17-166 7.4e-51 168.7 In-house 21-170 (308) alignment 
Range on Protein: 17-166
Range on HMM: 21-170/308.0
PEHPPVPVDNFAKHVHKlhKSDDRGFMIEYNKLDAGRE-FPCDVAYNSDNKAKNRYGNIVAYDHSRVVLneieNvRGSDYINASHIDGY--NKPNAYIAT
... ...|....|.. |  . |  ... |...| .  . ....||.  .|| |||| .|..||||||.|    .  ||||||||..|||  ..|...|||
vsslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIat

QGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDE----TEEYGDIGV
||| |.|..|||||||||..  |||||.|.|. . ||..|||.|    ..|||.. |
qgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftv
0039614 (Phosphotyrosine protein) phosphatases II 18-167 1.7e-49 164.3 In-house 10-159 (297) alignment 
Range on Protein: 18-167
Range on HMM: 10-159/297.0
EHPPVPVDNFAKHVHKLHKSDDRGFMIEYNKLDAGREfPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENV-RGSDYINASHIDGYNK-PNAYIATQG
|..|.|.. .. .........  ... |. .|    . .. .|.   || |||| .|..||||||.|. ...|  .|||||||..|||.. ....|||||
esipiplsvldlllllekansktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqg

PIPTTFDDFWRMVWEQQSASIVMLTNLQERHKlKCHKYWPDETEEYGDIGVQ
| | |..|||||||||.. .|||||.| |. . ||..|||.|...|||. | 
PlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeeggtygdftvt
subfamily_Ptp69D_pd Subfamily Ptp69D 20-167 2.6e-49 163.0 In-house 2-151 (307) alignment 
Range on Protein: 20-167
Range on HMM: 2-151/307.0
PPVPVDNFAKHVHKLHKSDDRGFMIEYNKLDA-GREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIP
.....|. .. ... ..  | |.. ||.|| |   .  . |. . .|. |||| .|.|.|. ||.|..|.    |||||||.| ||.. . .|| |.|. 
gaiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPve

TTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWP-DETEEYGDIGVQ
.| .|||||..||..  ||||.||.|  . ||.|||| ... .|||| |.
atigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvk
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 27-167 3.9e-49 162.3 In-house 9-151 (288) alignment 
Range on Protein: 27-167
Range on HMM: 9-151/288.0
FaKHVHKLHKSDDRGFMIEYNKL-DAGREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTTFDDFW
  ..| | ....  ||  |||.|   ...   ... .. |. |||| ||..||. || |.. |...|.||||||.|||..| ..|||||||.. | .|||
v.akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfW

RMVWEQQSASIVMLTNLQERHKLKCHKYWPDETE--EYGDIGVQ
..|.|...  |||||.| |. | ||..||||. .  .||.. |.
elvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvt
0045450 (Phosphotyrosine protein) phosphatases II 15-163 4.3e-48 160.0 In-house 2-164 (307) alignment 
Range on Protein: 15-163
Range on HMM: 2-164/307.0
NDPEHPPVPVDNFAKHVHKLHKSDDRGFMIEYNKLDAGREF---PCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENV-RGSDYINASHI--------D
. | ...... .. ..|..|....  |.  |..||     |   ....|.   || |||| .|..|||.||.|. ...   .|||||||..        |
dlplslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllld

GYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDEtE---EYGD
||......|||||| | |..|||||.|||..  |||||.| |. . ||..||||| .   .||.
gydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygn
0046845 (Phosphotyrosine protein) phosphatases II 43-166 5.8e-48 159.1 In-house 3-137 (284) alignment 
Range on Protein: 43-166
Range on HMM: 3-137/284.0
MIEYNKLDAGREF---PCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENV-RGSDYINASHIDGY-----NKPNAYIATQGPIPTTFDDFWRMVWEQQS
. |. .|     .   ...||.   |. |||| .|..||||||.|. ...   .|||||||..|||     ......|||||| |.|..|||||||||..
eeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnv

ASIVMLTNLQERHKLKCHKYWPDE--TEEYGDIGV
  |||||.| |. . ||..|||.|  . .|||. |
rvIVmltelvengrekcaqYwplegevltygdftv
0047943 (Phosphotyrosine protein) phosphatases II 39-166 1.5e-47 157.8 In-house 11-139 (273) alignment 
Range on Protein: 39-166
Range on HMM: 11-139/273.0
DRGFMIEYNKLDAGR-EFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLneieNVRGSDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIV
 .... |...|     .... ||.  .|| |||| .|..||||||.|    .  ||||||||..||||.....|||||| | |..|||||||||..  ||
ltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviV

MLTNLQERHKLKCHKYWPDE----TEEYGDIGV
|||.|.|... ||..|||.|    ...||.. |
mLtelvelgrekcaqYwpleggelsltygkftv
0036941 (Phosphotyrosine protein) phosphatases II 54-167 3e-47 156.7 In-house 28-140 (297) alignment 
Range on Protein: 54-167
Range on HMM: 28-140/297.0
EFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLneieNVRGSDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKY
 ....|| . .|. |||| .|..|||.||.|    .  ||||||||..|||. ....|||||| |.|..|||||||||.. .|||||.| |. . ||..|
lgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqy

WP---DETEEYGDIGVQ
||   .|. .|||. |.
wpleegesltygdftvt
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 58-167 4.2e-47 155.5 In-house 2-111 (250) alignment 
Range on Protein: 58-167
Range on HMM: 2-111/250.0
DVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLkCHKYWP-D
.|| . .|| |||| .|.|.|.|||||.. .  . |||||||...||.. .|.||||||...|. ||||||.|..|..|||||||.| .|  .|.||| .
svakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve

ETEEYGDIGVQ
..|.|||. |.
kaekyGdvtvs
DSPc_SM00195 45-167 9.9e-47 154.8 In-house 5-131 (263) alignment 
Range on Protein: 45-167
Range on HMM: 5-131/263.0
EYNKLDAGR-EFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQ
|..||.. . . ... |  . ||.|||| ||. |||.|| |...|.  |||||||..|.|.||...||||||| |.|..||||||||...  |||||. .
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteee

ERHKLKCHKYWPDE---TEEYGDIGVQ
|..| ||..|||.|   .|..|.| |.
engkekcdrywpeesggketfgkisvk
PTPc_SM00194 45-167 9.9e-47 154.8 In-house 5-131 (263) alignment 
Range on Protein: 45-167
Range on HMM: 5-131/263.0
EYNKLDAGR-EFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQ
|..||.. . . ... |  . ||.|||| ||. |||.|| |...|.  |||||||..|.|.||...||||||| |.|..||||||||...  |||||. .
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteee

ERHKLKCHKYWPDE---TEEYGDIGVQ
|..| ||..|||.|   .|..|.| |.
engkekcdrywpeesggketfgkisvk
subfamily_PTPN9_pd Subfamily PTPN9 27-167 1.6e-45 150.4 In-house 6-147 (297) alignment 
Range on Protein: 27-167
Range on HMM: 6-147/297.0
FAKHVHklhKSDDRGFMIEYNKLDAGR-EFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTTFDDFW
. ..|.   . . || . || .. .   |   ...    |  |||| ... ||..||||.....   ||||||...|||....|.||||||.. |..|||
lvayvk...ekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfW

RMVWEQQSASIVMLTNLQERHKLKCHKYWPDE---TEEYGDIGVQ
||||||.   ||| | . || .||| .|||.|   ..|.||. |.
rmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvs
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 21-167 1.1e-43 144.5 In-house 3-151 (305) alignment 
Range on Protein: 21-167
Range on HMM: 3-151/305.0
PVPVDNFAKHVHKLHKSDDRGFMIEYNKLDAGrEFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTT
.. .|..|..... .. .|.|.  .|..|    | ..||  .. ||||||. .|. .|..|. |.| |..  |||||||..|||.. ..||..|||...|
iialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlknt

FDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDETEE---YGDIGVQ
 .||||...| .  .|||||.|.|  | ||..|||... |   .|.. |.
vadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsve
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 22-168 5.5e-42 138.6 In-house 2-152 (290) alignment 
Range on Protein: 22-168
Range on HMM: 2-152/290.0
VPVDNFAKHVHKLHKSDDRGFMIEYNKLDAG-REFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRG--SDYINASHIDGYNKPNAYIATQGPIP
.|||.|...| . |.  ..||  ....||.| .|.   |.  |.|| .||. ||| ||  |..|..| . .    .||||..|.||.. ..|||||||..
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

TTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDE-TEEYGDIGVQL
 |  |||...|..... |||||| .| .| ||..||||. |..|| . ..|
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikl
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 21-167 6.8e-42 138.4 In-house 2-149 (315) alignment 
Range on Protein: 21-167
Range on HMM: 2-149/315.0
PVPVDNFAKHVHKLHKSddRGFMIEYNKLDAGREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTT
|.|| .|   | | ...    |  |.. |     ..  || ...|  ||||.||. .|..||.|. |..   |||||||.| .... .||||.||| ...
pipvaqfpafvnknrht..alfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkas

FDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPD---ETEEYGDIGVQ
 |||||||.... ..|||.|..||  |.|| .||||   .. |.| | |.
vddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikve
subfamily_PTPN6_pd Subfamily PTPN6 35-167 7.5e-42 138.4 In-house 21-159 (306) alignment 
Range on Protein: 35-167
Range on HMM: 21-159/306.0
HKSDDRGFMIEYNKL---DAGREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNeIENVRGSDYINASHIDG--YNKPNAYIATQGPIPTTFDDFWRMVW
.. .  ||. |...|   .| . .  . .   .|| |||| ||. .||.||.|.  ..| |||||||. |..   .. ..|||||| ..||  |||||||
eslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvw

EQQSASIVMLTNLQERHKLKCHKYWPDET--EEYGDIGVQ
...|  |||.|.  || | || .|||||.  ||||.| |.
qensrvivmttkevErgkekCarYWPdeeekeeyGkisvt
0040439 (Phosphotyrosine protein) phosphatases II 56-166 1.4e-41 138.1 In-house 2-113 (249) alignment 
Range on Protein: 56-166
Range on HMM: 2-113/249.0
PCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWP
...||.   || |||| .|..||||||.|. .... .|||||||.||||. ....|||||| | |..|||||.||... .|||||.|.|. . ||..|||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

-DETEEYGDIGV
 ... ||||. |
lggsleygdftv
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 20-160 1.6e-41 137.7 In-house 14-150 (319) alignment 
Range on Protein: 20-160
Range on HMM: 14-150/319.0
PPVPVDNFAKHVHKLHKSDDRGFMIEYNKLDAGREFPCDVAYN--SDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPI
|..|. .  . ...  . | . . .|....       .| ..    .|| |||..||.|.|...| |. .. . .|||||||...|| ... |||.||| 
pdfpayyqqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPl

PTTFDDFWRMVWEQQSASIVMLTnlqerhKLKCHKYWPDETEE
. | .|||||.||.....||.||      | || .||| ....
dntladfWrmiweyncstivllt......kdkcsqywplkivi
Y_phosphatase Protein-tyrosine phosphatase 65-167 2.2e-41 137.2 Pfam-A 1-104 (235) alignment 
Range on Protein: 65-167
Range on HMM: 1-104/235.0
NKAKNRYGNIVAYDHSRVVLneiENVRG-SDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWP---DETEE
|| |||| .|..||..|| |   ..  | ||||||....||......||||||.. |..|||||||.... .|||||.|.|... ||..|||   .|...
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGDIGVQ
|||| |.
ygdikve
Y_phosphatase Protein-tyrosine phosphatase 65-167 2.2e-41 137.2 In-house 1-104 (235) alignment 
Range on Protein: 65-167
Range on HMM: 1-104/235.0
NKAKNRYGNIVAYDHSRVVLneiENVRG-SDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWP---DETEE
|| |||| .|..||..|| |   ..  | ||||||....||......||||||.. |..|||||||.... .|||||.|.|... ||..|||   .|...
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGDIGVQ
|||| |.
ygdikve
0042113 (Phosphotyrosine protein) phosphatases II 57-164 7.4e-41 135.6 In-house 1-109 (245) alignment 
Range on Protein: 57-164
Range on HMM: 1-109/245.0
CDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWP-
..||.   || |||| .|..|||.||.|.....  .|||||||..|||. .. .|||||| | |..|||||.||... .|||||.. |... ||..||| 
ysvallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl

DETEEYGDI
.|. .|||.
gesltygdf
0045098 (Phosphotyrosine protein) phosphatases II 42-164 1.4e-40 134.8 In-house 10-121 (278) alignment 
Range on Protein: 42-164
Range on HMM: 10-121/278.0
FMIEYNKLDAGREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVlneienvrgsDYINASHIDGYnkPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTN
... ...|  |    . .|   .|..|||| .|..||||||.          ||||||.||||  |...|||||| |.|..|||||.||... .|||||.
llefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmlte

LQERHKLKCHKYWPDET-EEYGDI
|.|. . ||..|||..  ..|||.
lvelgrekcaqywpeggsltygdf
subfamily_PTPN12_pd Subfamily PTPN12 47-161 2.8e-40 133.0 In-house 22-136 (290) alignment 
Range on Protein: 47-161
Range on HMM: 22-136/290.0
NKLDAGREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERH
.|. | .... ... .. |..|||| .|. ||.|||.|..||.. |||||||..| | ... .|||.|||.|.| ||||||.||..   .||. .. |  
ekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelg

KLKCHKYWPDETEEY
| ||..|||.|.|| 
kkkCerYWpeegeee
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 21-166 3.5e-40 132.6 In-house 1-147 (515) alignment 
Range on Protein: 21-166
Range on HMM: 1-147/515.0
PVPVDNFAKHVHKLHKSddRGFMIEYNKLDAGREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTT
|.|. .|   | |  .     |  |.. |     .|  || .  |  ||||.||. || .|| |. |..   |||.|||.| ...  .||||.||| ...
plplaqfPafvnknrht..tlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkas

FDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPD---ETEEYGDIGV
 |||||.|.... . |.|.|.|.|  | || |||||   .. ..| | |
vddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikv
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 63-160 4.3e-40 133.0 In-house 23-114 (284) alignment 
Range on Protein: 63-160
Range on HMM: 23-114/284.0
SDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTnlqerhKLKCHKYWPDETEE
 .|| |||.|.|.|.|...| |. .  . .|||||||.| || ... ||||||| . | .|||||.||.....||.||      | || .||| ....
dqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 62-167 3.1e-39 129.6 In-house 5-111 (239) alignment 
Range on Protein: 62-167
Range on HMM: 5-111/239.0
NSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYN-KPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDETEE
.  ||||||| |||.||||||||... |   |||||||..  |.  |.||||||| . ..  |||||.|... . ||||| | | || |||.|||| | .
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk

YGDIGVQ
| .. | 
ycnlrvt
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 63-167 3.8e-39 129.3 In-house 5-110 (239) alignment 
Range on Protein: 63-167
Range on HMM: 5-110/239.0
SDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYN-KPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDETEEY
  ||||||| |||.||||||||... |   |||||||..  |.  |.||||||| . ..  |||||.|... . ||||| | | || |||.|||| | .|
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsky

GDIGVQ
 .. | 
cnlrvt
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 22-166 1.1e-38 127.9 In-house 2-145 (287) alignment 
Range on Protein: 22-166
Range on HMM: 2-145/287.0
VPVDNFAKHVHKLHKSDDRGFMIEYNKLDAGREFPCDV--AYNSDNKAKNRYGNIVAYDHSRVVLNeienVRGSDYINASHIDGYNKPNAYIATQGPIPT
.||..|.. |.| |.  . ||.  .  |.   . . .|  .  |.|| |||. .|. .|  ||.|.     .  |||||..||||.. .|.|....|.  
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfn

TFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDET-EEYGDIGV
|  .||.......   ||||....| .. .|..|||.|.   .|.  .
tarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyni
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 18-167 1.3e-38 127.8 In-house 6-151 (297) alignment 
Range on Protein: 18-167
Range on HMM: 6-151/297.0
EHPPVPVDNFAKHVHKLHKSDdrGFMIEYNKLDAGREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKpnAYIATQGPI
|  |.|. .||  | | ...|   | .|.. | .   .|  || .  |  |.|| ||. || ||| |. ...   |||.|||.. |...   .|.|| | 
errpiplsdfatlvqknrhtd..vfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPm

PTTFDDFWRMVWEQQSASIVMLTNLQERHKlKCHKYWPDET-EEYGDIGVQ
..| .|||.||...| . ||||....||.| || .||.|..  ..||. |.
katvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvv
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 24-167 1.1e-37 124.6 In-house 4-146 (439) alignment 
Range on Protein: 24-167
Range on HMM: 4-146/439.0
VDNFAKHVHKLHKSDDRGFMIEYNKLDAGR-EFPCDVAY--NSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTT
 |.| .|| ||.| ..  |  ...|... . .. |. .   .. ...|||| ...|.||.||.|.||  |  | |||| .|.|| ... |||||||   |
rdefqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkket

FDDFWRMVWEQQSASIVMLTNLQERHKlkchkYWPDETEEY-GDIGVQ
 |||||.|.|.... ||||||| | .|     ||| ..| . ||| |.
tddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavr
subfamily_CG7180_pd Subfamily CG7180 55-167 4.6e-37 122.2 In-house 32-144 (296) alignment 
Range on Protein: 55-167
Range on HMM: 32-144/296.0
FPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKlKCHKYW
  |  .....|. |||. ..| ||. ||||....    ||||||...|.. |...|| |..|   | |.|||.|..... ..|.||.  . .| ....||
gdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsyw

PDE-TEEYGDIGVQ
| .  |.||.| |.
pnkskeqygeifve
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 63-166 4.8e-37 122.4 In-house 1-105 (237) alignment 
Range on Protein: 63-166
Range on HMM: 1-105/237.0
SDNKAKNRYGNIVAYDHSRVVLNEIENvrGSDYINASHIDGYN-KPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDE--TE
|.||.|||||||||||||||||.   .  |||||||....|..  |. |||.|||. .. ||||.|||... . ||||| | |. .||||||||.    .
senkiknrygnivaydhsrvvlkgags..gsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpa

EYGDIGV
 || . |
aygvltv
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 32-161 8.9e-37 121.4 In-house 8-141 (301) alignment 
Range on Protein: 32-161
Range on HMM: 8-141/301.0
HKLHKSDDRgFMIEYNKLDAGREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIEN--VRGSDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVW
|.  |  .. |  .|..|. |.. .|.| ....||| ||. ||. ||. |..|.. .|  .   .|||||.||||.. ...||.|||.  |  ||||..|
hvaakhsnk.feeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliw

EQQSASIVMLTNLQERHKLKCHKYWPDETEE---Y
... .||||.|||.|. | ||..|||. ..|   .
qekpvsivmvtnlkegtkskceqywpnseaeseef
0037934 (Phosphotyrosine protein) phosphatases II 57-167 1.2e-36 121.9 In-house 2-106 (243) alignment 
Range on Protein: 57-167
Range on HMM: 2-106/243.0
CDVAYNSDNKAKNRYGNIVAYDHSRVVLneienvRGSDYINASHIDGYNKpnaYIATQGPIPTTFDD----FWRMVWEQQSASIVMLTNLQERHKLKCHK
. .|    |. |||| .|..||||||.|       |||||||..|.....   .|||||| | |..|    ||||.||... .|||||.|.|. ..||..
fsiallpenlsknrysdilpydhsrvkl......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPDETeEYGDIGVQ
|||.|. .|||. |.
ywpgev.tygdftvt
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 23-167 1.3e-36 121.3 In-house 6-152 (325) alignment 
Range on Protein: 23-167
Range on HMM: 6-152/325.0
PVDNFAKHVHKLHKSDDRGFMIEYNKLDAGREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTTFD
 | |. .||.| .  |. ||  |.. | .       ||   .||||||. |.||.|.|||||.  ..   |||||||..  . | . ..|.| | ..| .
avvnlvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatin

DFWRMVWEQQsASIVMLTNLQERHKLKCHKYWPDE---TEEYGDIGVQ
|.||.| . . .|.|...|  .  | .| .|||.|   . ..| . |.
dlWrlvldWr.csvvvvlneldlgkdrcavywpkemgksktfGglevk
subfamily_PTPN1_pd Subfamily PTPN1 52-159 1.7e-36 120.5 In-house 19-122 (290) alignment 
Range on Protein: 52-159
Range on HMM: 19-122/290.0
GREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENvrgsDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCH
 ..||. .| .  |...||| ..  |||||..|.. .|    |||||| ..  .    || ||||.| | | ||.|||||.| ..||| .. |....||.
asdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikca

KYWPDETE
.||| . |
qywPqgee
subfamily_PTPN3_pd Subfamily PTPN3 53-163 2.7e-36 119.9 In-house 29-141 (280) alignment 
Range on Protein: 53-163
Range on HMM: 29-141/280.0
REFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENvrgsDYINASHI----DGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKL
..  ...|  ..| .|||| .|..||. || |.| |.    |||||...    .. .  | |||||||...|  |||.|||||.|  |||||.| || . 
pglaisaarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrv

KCHKYWPDETEE--YGD
|||.|||....|  ||.
kChqyWPetedeleyge
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 64-166 5.2e-36 119.1 In-house 27-136 (274) alignment 
Range on Protein: 64-166
Range on HMM: 27-136/274.0
DNKAKNRYGNIVAYDHSRVVLN-EIENVRGSDYINASHIDGYN-KPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDETEE-
 .. |||| .|.  ..|||.|. |  .   |.|||| .| ||. . .||.|||||.|.| .|||||......  |||||.|.|... ||..|.||...  
gsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedye

----YGDIGV
    |||. .
iserygdvei
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 60-157 1.6e-34 114.0 In-house 33-129 (287) alignment 
Range on Protein: 60-157
Range on HMM: 33-129/287.0
AYNSDNKAKNRYGNIVAYDHSRVVLNEiENVRGSDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDE
| .  .  ||||.... .|..||.| . |   ||||||| .. .|.. .|.||.||||..|  ||||.|.|..|||....|   |  .|||.||||. 
aeelaavkknryadvlPiddtrvllsa.egelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 46-162 2.2e-34 113.7 In-house 1-118 (270) alignment 
Range on Protein: 46-162
Range on HMM: 1-118/270.0
YNKLDAGREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYN-KPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQE
...|| ... . |.     .|. ||| .|.   ..||.|.|.|.   . |||| .. |.. ....|||..|| |||  .||||.||... .|||.|.|.|
fkeldkeetsesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleE

RHKLKCHKYWPDETEEYG
. . || .||| |..|  
kgrkkCerYWpaepkekv
subfamily_PTPN13_pd Subfamily PTPN13 55-159 2.3e-34 113.9 In-house 27-128 (273) alignment 
Range on Protein: 55-159
Range on HMM: 27-128/273.0
FPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENvrgsdYINASHIDGYN--KPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHK
  |.|. . .||.|||| |.. ||..|| |..  .     |||||.|      .   |||.|||.|.| .|||.|||||..  |.|.|. .|. |.|||.
dtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchr

YWPDETE
|||....
ywPeskn
subfamily_PTPN23_pd Subfamily PTPN23 59-166 2.2e-33 110.3 In-house 37-144 (288) alignment 
Range on Protein: 59-166
Range on HMM: 37-144/288.0
VAYNSDNKAKNRYGNIVAYDHSRVVLNeienVRGSDYINASHIDGYN-KPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDE
.|    .  |||. .|. |||.||.|.        ||||||.. .       .||||.|...|  |||.||.||.|  ||||.. .|..| |...||| .
iaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPed

---TEEYGDIGV
   |...||. |
kgetvkfgdlsv
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 21-157 2.5e-33 110.0 In-house 3-145 (392) alignment 
Range on Protein: 21-157
Range on HMM: 3-145/392.0
PVPVDNFAKHVHKLHKSddRGFMIEYNKLDAGREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTT
|.|| .|   |.| ..|    |. |.  |     .|  || . .|. ||||.||. || .||.|. |...  |||.|||.|....  .||||.||| ...
pipvaqfpafveknrhs..alffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaas

FDDFWRMVWEQQSASIVMLTNLQERHKL----KCHKY----WPDE
.|||||||.... ..|.|.|.|.|  |      . ..    |||.
lddfwrmvfqenvttiamvtklkegdkgddartvaqfhftewPdk
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 53-167 9.6e-33 108.3 In-house 21-135 (283) alignment 
Range on Protein: 53-167
Range on HMM: 21-135/283.0
REFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENvrgsDYINASHID---GYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLK
 . ..|.| ...|| |||. .||..|  || |.   .    |||||..|     |.. . ||..|.|.  |  |||.||.... ..|||||.|||  . |
pdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrik

CHKYWPDE-TEEYGDIGVQ
| .||| . .|.||.  | 
CsqyWPkrGsedyGeftvt
subfamily_PTPN14_pd Subfamily PTPN14 26-160 1.3e-32 108.1 In-house 11-145 (300) alignment 
Range on Protein: 26-160
Range on HMM: 11-145/300.0
NFAKHVHKlhKSDDRGFMIEYNKLDAGRE-FPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVrGSDYINASHIDGY--NKPNAYIATQGPIPTTFD
. ||...|  | ..     ||...   ||   ...| . .|. |||. ... |...|| |.  ..   ..|||||.|      |   ||..|||...|  
krakilek..kleegkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvq

DFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDETEE
|||.|||||. . |||||. .|  | |..||.|.....
dfWqmvWeqgvqlivmlteeeedgkeksfkyfPklesk
subfamily_ptpA1_pd Subfamily ptpA1 26-157 5.2e-32 106.1 In-house 12-138 (418) alignment 
Range on Protein: 26-157
Range on HMM: 12-138/418.0
NFAKHVHKLHKSDDRGFMIEyNKLDAGREFPCDvayNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGyNKPNAYIATQGPIPTTFDDFW
|. .|.. .||  .   ..| . .        |   .  | .|||| ||.  .|.|| |..|..  ||||||| .|||   |. .|.||||.| |  |||
nlknhikcihkikeefrlle.esvgpsetsegd...kkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfw

RMVWEQQSASIVMLTNLQERHKLKCHKYWPDE
|||||..   ||||.   |  ..|| .|||..
rmvwenrcriivmlsresencrikcdrywpeq
subfamily_PTPRN_pd Subfamily PTPRN 56-160 6.8e-32 105.4 In-house 47-152 (297) alignment 
Range on Protein: 56-160
Range on HMM: 47-152/297.0
PCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHID-GYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYW
 ..|| . .|  |||. ....|||||| |.|  .   ||||||| |     .  ||||||||...|  |||.||||| .. ||.||.|.|    .|..||
tkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckryw

PDETEE
||| .|
pdeGse
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 65-160 1.5e-27 91.2 In-house 33-128 (297) alignment 
Range on Protein: 65-160
Range on HMM: 33-128/297.0
NKAKNRYGNIVAYDHSRVVLNEieNVRGSDYINASHIDGYNKP--NAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDETEE
   |||| .|.|.| .|| |     . ..||||| ..   ...    || .|||. .| ||||..|.||.   |||...|||  . ||  |||.  .|
slrknryrdilatddtrvkllr..viterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqe
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 64-166 9.3e-26 85.4 In-house 46-160 (350) alignment 
Range on Protein: 64-166
Range on HMM: 46-160/350.0
DNKAKNRYGNIVAYDHSRVVLN--------EIENVRGSDYINASHIDGY-----NKPNA-YIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLK
.  ||||| ||. |.|||| |.            ....|||||...         .|.  |||||.|.| |.|||.... . .   |..||...|    |
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek

CHKYWPDEteEYGDIGV
|..||..   .| || |
cyrYWqeg..sydditv
0049772 (Phosphotyrosine protein) phosphatases II 53-155 1.1e-25 86.5 In-house 34-164 (314) alignment 
Range on Protein: 53-155
Range on HMM: 34-164/314.0
REFPCDVAYNSDNKAKNRYGNIVAYDhSRVVLnEIENVRGSDYINASHIDGYnkpNAYIATQGPIPTTFDDF----------WRMV--WEQQSASIVM--
.|. . ||.   |. |||| .|. .| .||.|   ..|.||||||||..||.   ...|||||| . |..||          ||||  .....  |||  
peltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsr

-------------------LTNLQERHklkchK-----YWP
                   |..| ...           ...
devladelsrLdaAlgKtpllildgng.....neptaadle
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 38-166 1.2e-24 81.5 In-house 25-154 (310) alignment 
Range on Protein: 38-166
Range on HMM: 25-154/310.0
DDRGFMIEYNKLDAGREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLnEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIV
   |.. .| |||| ..         ..  |||| ..|  | ||| | .|.. |  ||| | ..      ...| .|||.  |  |||||...... ||.
gieglvkqyrkldakqdssltyeaykkymhknrysdvvcldtsrvkl.kidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesil

MLTNLQERHKLKCHKYWPD--ETEEYGDIGV
.| .  |  . ||  |||    || || | |
llckvgeegrpkcvgywpslgvtetygcirv
0041856 (Phosphotyrosine protein) phosphatases II 65-161 2.7e-24 81.2 In-house 1-78 (182) alignment 
Range on Protein: 65-161
Range on HMM: 1-78/182.0
NKAKNRYGNIVAYDHSRvvlneienvrGSDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTnlqerhklkCHKYWPDETEEY
|. |||| .|. |||||          ..|||||. ..|. ... .|||||| . |. ||.||..|..  .||.||         .. |||.. | .
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpellerl
subfamily_CG42327_pd Subfamily CG42327 64-167 9.4e-24 78.6 In-house 27-136 (319) alignment 
Range on Protein: 64-167
Range on HMM: 27-136/319.0
DNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYN-KPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWP-----DE
  | |.|. |.|   ..||||..| .   . |..||.. ||.  || |||.| .   .  ||||.||||||  || ||.|.|    .| .|.|     |.
tskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldn

TEEYGDIGVQ
|. |||| | 
tslyGdilvt
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 62-158 1.3e-22 75.2 In-house 38-132 (307) alignment 
Range on Protein: 62-158
Range on HMM: 38-132/307.0
NSDNKAKNRYGNIVAYDHSRVVLNEieNVRGSDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDET
 | |  |||| .. . |..|.|..   .   |||| | ..    ||. .|..|||  .|  .|| |. ...  |..|| .. |  |.||..||| | 
fsantdknryqdvkcqdkgrivvkf..dglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywplee
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 63-160 2.2e-22 74.1 In-house 54-146 (290) alignment 
Range on Protein: 63-160
Range on HMM: 54-146/290.0
SDNKAKNRYGNIVAYDHSRVVLNEIENvrgSDYINASHIDGYNKPnaYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDETEE
  .  |||| ..|  | .||.|..  .    ||. | ...| . .  .| |||..  |  |.|||| ... | |||| .| |  | ||..|.|..  |
ntefkknrykdvvcndktrvilkdGyd...GdyvhanyvkGlkam..filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGe
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 57-157 3.3e-22 73.5 In-house 29-130 (281) alignment 
Range on Protein: 57-157
Range on HMM: 29-130/281.0
CDVAYNSDNKAKNRYGNIVAYDHSRVVLNE-IENVRGSDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWP
| |  .  |. |||| || . | ||| |.  . |   .||| | .|        || ||||   |  |||||.|......|||| .. |  . || .|.|
ctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfp

DE
 .
rn
subfamily_egg_pd Subfamily egg 26-159 9.1e-22 72.1 In-house 4-132 (307) alignment 
Range on Protein: 26-159
Range on HMM: 4-132/307.0
NFAKHVHKLHKSDDRGFMIEYNKLDagrEFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTTFDDFW
..||.. .. .  .| ...  .  |   | .   |....|. | |   .   | ||| |.  .     |.| | ...|    | .| .| |.  | ||||
kkakylseivqelerrlevleesvd...eislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfw

RMVWEQQSASIVMLTNLQERhkLKCHKYWPDETE
|||....   |||||  .|    .|. |||   .
rmvfqeevqyivmltsrkes..erceyywpkaes
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 57-163 2.2e-20 67.8 In-house 25-127 (267) alignment 
Range on Protein: 57-163
Range on HMM: 25-127/267.0
CDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVrgsdYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHklkCHKYWPD
.   . ..|...||. . . ||..||.| . |.     |||||...||.. ||.|.||.|.  |  ||. .. .|. . ||.||.  .      ...|| 
isqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdn...irlfwPP

E---TEEYGD
.   ...| |
kmgqakkyqd
0051429 (Phosphotyrosine protein) phosphatases II 92-160 2.5e-20 68.7 In-house 3-86 (272) alignment 
Range on Protein: 92-160
Range on HMM: 3-86/272.0
GSDYINASHIDGYNK---PNAYIATQGPIPTTFDDFWRMvWEQQSASIVMLTNLQERHKLKCHKYWP-------------DETEE
 |.||||....||..   |.......|| | | .||||. .|..  .||.|... || .|||..|||             ..| .
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptil
0036282 (Phosphotyrosine protein) phosphatases II 92-166 6e-19 63.8 In-house 1-70 (174) alignment 
Range on Protein: 92-166
Range on HMM: 1-70/174.0
GSDYINASHIDGYNKPNAYIATQGPIPttfddFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDETEEYGDIGV
||||||||..|..  .. .||.||| .     ||.|..|... ..|||....|... ||. |||.  | . . |.
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpelredlerlgi
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 61-160 2e-18 61.1 In-house 51-148 (305) alignment 
Range on Protein: 61-160
Range on HMM: 51-148/305.0
YNSDNKAKNRYGNIVAYDHSRVVLNEIEnvrGSDYINASHIDGYNKPN-AYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDETE
 .  ...|||| .. . |.| | |..      |||| | ..     |.  .|..|||.  | |.|| || ...   |||| .  |  |||| .|||    
sadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqg

E
|
e
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 19-115 2.3e-18 60.2 In-house 2-95 (95) alignment 
Range on Protein: 19-115
Range on HMM: 2-95/95.0
HPPVPVDNFAKHVHKLHKSDDRGFMIEYNKLDAGREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNeieNVRGSDYINASHIDGYNKPNAYIATQG
  |. |  |  || ..|   |. |  |.. .      |  |     |  |||. ||. || .||||      | ||||||  .||| . |.|||.||
fkpihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlt...tkrdsdyinacfvdgyarkncyiaaqg
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 37-158 3.6e-18 60.4 In-house 19-138 (305) alignment 
Range on Protein: 37-158
Range on HMM: 19-138/305.0
SDDRGFMIEYNKLDAGREFPCDVAY-NSDNKAKNRYGNIVAYDHSRVVLneiENVRGSDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSAS
   .|.  |.. .    .|    |. ..... |||| ..   |. || |   |.    .|| | ..    .|. .| || |.  |  ||| | ....  .
kgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkvea

IVMLTNLQERHKLKCHKYWPDET
| || ||.|.   ||..|.. . 
ifmlcnllekgakkcleyfaskd
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 57-161 7.2e-18 59.5 In-house 27-128 (285) alignment 
Range on Protein: 57-161
Range on HMM: 27-128/285.0
CD-VAYNsDNKAKNRYGNIVAYDHSRVVLNEIEnvrgSDYINASHIDGYNKP-NAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYW
|   ||.  |   ||| .. . . .||||.. .     ||| || .    |  ..||.||||.| |. |||.|..... | ..||  | |    ||  |.
ctytaye.anpdlnryadvrcieetrvvlknhd....rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyy

PDETEEY
|..  | 
peklgev
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 21-103 1.6e-17 57.9 In-house 5-85 (440) alignment 
Range on Protein: 21-103
Range on HMM: 5-85/440.0
PVPVDNFAKHVHKLHKSddRGFMIEYNKLDAGREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDG
|. | .|| .|.. ..|  | |  |.. | .|   |.|.|   .|| |||| ||.|||||||.|.|.. |  |||||||.|.|
piivadfadyvqnnrrs..rafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasying
0046846 (Phosphotyrosine protein) phosphatases II 89-160 1.9e-17 59.0 In-house 8-75 (176) alignment 
Range on Protein: 89-160
Range on HMM: 8-75/176.0
NVRGSDYINASHIDGYnkpnAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDETEE
   ..|||||. |.|.    ..||||||.| |. ||..|..|..   .|.||...| ..|||. |||.....
ldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpelekl
0043147 (Phosphotyrosine protein) phosphatases II 92-156 4.3e-17 57.8 In-house 4-75 (172) alignment 
Range on Protein: 92-156
Range on HMM: 4-75/172.0
GSDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQER-------HKLKCHKYWPD
||||||||..|.| .|. .|||||| . |..|||||..|..   ||.||.|.             .. .|||
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpD
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 65-167 3.4e-16 53.5 In-house 48-164 (349) alignment 
Range on Protein: 65-167
Range on HMM: 48-164/349.0
NKAKNRYGNIVAYDHSRVVLNEI--------------ENVRGSDYINASHI--DGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKL
  ||||| .|. |.||||.|..               .  .  ||||| ..    ..  . ||||| |.|.| |||....  ..   .. |.. .|    
lfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsle

KCHKYWPDEteEYGDIGVQ
||..|| .   .| .| |.
kcdiywqel..sysnitvk
0049260 (Phosphotyrosine protein) phosphatases II 101-154 1.1e-15 53.1 In-house 2-55 (152) alignment 
Range on Protein: 101-154
Range on HMM: 2-55/152.0
IDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYW
||||..|...|||||| | |..|||||..|..   |||||.|.|..||||..|.
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi
0044763 (Phosphotyrosine protein) phosphatases II 77-158 2.1e-15 52.3 In-house 2-74 (178) alignment 
Range on Protein: 77-158
Range on HMM: 2-74/178.0
YDHSRVVLNEIENVRGSDYINASHIDGYnkpnAYIATQGPipttfDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDET
.|..||.|...|.. .|||||||.|...     |.....|      |......|.   .||.||. .|...|||..|||.|.
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeea
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 66-165 2.2e-15 51.2 In-house 51-147 (301) alignment 
Range on Protein: 66-165
Range on HMM: 51-147/301.0
KAKNRYGNIVAYDHSRVvlNEIENVRGSdYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDETEEYGDIG
| |.|| ..    .. |  . |.. .    | |  |.   .|. .||||||.. | .||| |.   .   ||||..  |... ||..| | ...|  |||
kdkhryptvPckPstav..evivdGkrv.PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldig
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 60-157 5.2e-15 49.7 In-house 91-181 (244) alignment 
Range on Protein: 60-157
Range on HMM: 91-181/244.0
AYNSDNKAKNRYGNIVAYDHSRVVLNEieNVRGSDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHklkchKYWPDE
|.| .|  ||| |  . .| .|| |..     |  ||||| .    .   || || |.  |  |||.|. |.    .|.|  ..|       .|||| 
afnpnnswknregaglpfdfnrvplsk..gsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed.....eywpds
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 66-156 3.4e-14 47.2 In-house 44-130 (312) alignment 
Range on Protein: 66-156
Range on HMM: 44-130/312.0
KAKNRYGNIVAYDHSRVVLNEIENVrgsdYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPD
|  ||| ||  .|  |  |   ||     || |  .    ||. ...||||.  |   ||...    |.||..|. . |    || ||  |
kdlnrypniqcwdrgrftlagdenf....yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisd
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 64-151 3.5e-14 47.0 In-house 33-119 (332) alignment 
Range on Protein: 64-151
Range on HMM: 33-119/332.0
DNKAKNRYGNIVAYDHSRVVLNEIENvrGSDYINASHIDGYNKPNAYIATQGPIPT-TFDDFWRMVWEQQSASIVMLTNLQERHKLKCH
.|   ||   . ..||||| |   .     |. ||| .|||.| .||| .| |.   |   ||||| |.. . |... ...|..| |. 
nnmdmnriphlycfdhsrvelapqdg..kddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkap
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 64-159 9.4e-14 46.1 In-house 42-133 (288) alignment 
Range on Protein: 64-159
Range on HMM: 42-133/288.0
DNKAKNRYGNIVAYDHSRVVLNeienvRGSD-YINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDETE
.| ...|| |.   | .|| |.       .| ||.|  .   . ..  | .| |. .| . .|.|. |..   ||||..| |. | |  .|.| .  
anptrdryenlprcditrvkls.....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklG
subfamily_eak_pd Subfamily eak 63-161 1.5e-13 44.9 In-house 50-146 (332) alignment 
Range on Protein: 63-161
Range on HMM: 50-146/332.0
SDNKAKNrYGNIVAYDHSRVVLNEIENVRgSDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDETEEY
 ..  .|   .|| ||.  | |      |   ||||| ..  .  . || |  .  .    ||.|| ||.| .||.| .  | .  |  ||.||.| | 
leavnrn.vvkivpydrylvrltssqlnr.lGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktree
0051082 (Phosphotyrosine protein) phosphatases II 93-161 4.4e-13 44.6 In-house 3-60 (151) alignment 
Range on Protein: 93-161
Range on HMM: 3-60/151.0
SDYINASHIDGYnkpnaYIATQGPIPttfdDFWRMVWEQQSASIVMLTNLQERHklKCHKYWPDETEEY
|||||.| ..|.     .....|| .    ||.....|..  .||.|....||   .|..|.|..  |.
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelgiev
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 64-141 6.3e-13 42.9 In-house 36-118 (347) alignment 
Range on Protein: 64-141
Range on HMM: 36-118/347.0
DNKAKNRYGNIVAYDHSRVVLNeIEN---VRG---SDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTN
 . .|||  .    | .||||   |.    |      |||||||   |  . || || |.| |  |||.||   . . .| . .
kslsknrskdvklidatrvvls.peksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtife
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 101-159 1.6e-12 41.5 In-house 229-284 (440) alignment 
Range on Protein: 101-159
Range on HMM: 229-284/440.0
IDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERhklKCHKYWPDETE
..|| | ||.|||| |. .|  ||||.| . . ..|.|| .|...    |  ||| .| 
fegyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntr
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 64-155 2.3e-12 41.1 In-house 46-130 (303) alignment 
Range on Protein: 64-155
Range on HMM: 46-130/303.0
DNKAKNRYGNIVAYDHSRVVLNEienvrgSDYINASHIDGYNKpNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWP
.|  |||. ...  |||.| | .      | || ||...   . .  | || |.. |  |||.|. ||.   ...|    | .||  .  .|
knmdknrfvdvicldhskvklsd......ssyihasyleldss.kkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfp
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 109-163 4.8e-11 37.2 In-house 6-60 (199) alignment 
Range on Protein: 109-163
Range on HMM: 6-60/199.0
AYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDETEEYGD
 ||||| |.  |. |||.||||  |  |||. . |  ..     |||      | 
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgk
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 109-163 5.2e-11 37.1 In-house 5-59 (198) alignment 
Range on Protein: 109-163
Range on HMM: 5-59/198.0
AYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDETEEYGD
 ||||| |.  |. |||.||||  |  |||. . |  ..     |||      | 
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgk
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 59-156 2.6e-10 33.5 In-house 21-86 (169) alignment 
Range on Protein: 59-156
Range on HMM: 21-86/169.0
VAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINAshidgynkpnayiatqgpipttfddfwRMVWEQQSASIVMLTNLQERHklkchKYWPD
.|  . |..|||    .|  | || |. . .  |||||||                           ||.|| ... ||.| . ...       .||.
maeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddkn.....nfwpe
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 64-163 2.8e-10 34.1 In-house 50-147 (302) alignment 
Range on Protein: 64-163
Range on HMM: 50-147/302.0
DNKAKNRYGNIVAYDHSRVVLNEienvRGSDYINASHIDGYNKPNAYIATQGPIPTTF---DDFWRMVWEQQSASIVMLTNLQERHKlKCHKYWPDETEE
.| .||.  .. ..|. .| |..    .  .|.|||...  .  .  | .| |. ..    ..|||||.... .|.|.|   .| .|   ....| ....
knlkknqsedvpildsnlvklea....epdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgd

YGD
| .
yke
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 59-156 3.4e-10 33.0 In-house 20-85 (169) alignment 
Range on Protein: 59-156
Range on HMM: 20-85/169.0
VAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINAshidgynkpnayiatqgpipttfddfwRMVWEQQSASIVMLTNLQERHklkchKYWPD
.|  . |..|||    .|  | || |. . .  |||||||                           ||.|| ... ||.| . ...       .||.
maeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddkn.....nfwpe
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 50-104 5e-09 30.1 In-house 24-77 (244) alignment 
Range on Protein: 50-104
Range on HMM: 24-77/244.0
DAGREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIeNVRGSDYINASHIDGY
|  |||    |  | | .|||| ||. .|..||.|.   .  |||||||..|.| 
dhtreflqtnavlsanatknryinilpfdetrvilsss.kkegsdyinanyiqgs
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 86-157 9.6e-09 29.6 In-house 6-72 (130) alignment 
Range on Protein: 86-157
Range on HMM: 6-72/130.0
EIENVRGSDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHklkchKYWPDE
|.. ..| .||||| .   .. . |. || |.  |  |||.|. |.    .|.|  ..|       .|||| 
evsrlqgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed.....eywpds
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 66-160 2.6e-08 28.4 In-house 20-123 (290) alignment 
Range on Protein: 66-160
Range on HMM: 20-123/290.0
KAKNRYGNIVAyDHSRVVLNEIENVRGSDYINASHIDgYNKPNAYIATQGPIPT-------TFDDFWRMVWEQQSASIVMLTNLQERHKL----KCHKYW
. ..|. . ..  ..||||..  .   .||| |...  . .  . |.|| |          |  .|| |. . .. ..||| . .|...      | || 
emdqRlevpLv.eatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYv

PDETEE
|.. .|
pesvge
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 108-160 8.9e-08 26.5 In-house 35-80 (255) alignment 
Range on Protein: 108-160
Range on HMM: 35-80/255.0
NAYIAtqgpiptTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDETEE
| |.        | | |....  ...  .|||....|  . ||..|.| | .|
nlysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekde
subfamily_hpo-7_pd Subfamily hpo-7 117-160 9.4e-07 23.0 In-house 43-86 (263) alignment 
Range on Protein: 117-160
Range on HMM: 43-86/263.0
IPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDETEE
.  | | |....  ...  .|||.. .|  . || .|.| | .|
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekde