Gene NvecPTP-Un-3 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP070_AA protein Get Run
NvecP070_AA_24-167 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 19-168 1.5e-74 246.7 In-house 2-152 (564) alignment
Range on Protein: 19-168
Range on HMM: 2-152/564.0
HPPVPVDNFAKHVHKLHKSDDRGFMIEYNKLDAGREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIP
..|.||.....||.||....|  |. ||.|.. |..|....| .. ||||||| ||||||||||||...|.. ||||||||.||||.|..||||||||..
skpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPla

TTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDE-TEEYGDIGVQL
.|..|||||||||.|..|||||.|.|..| |||||||.. ||.||.. |.|
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtl

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 22-167 4.9e-60 198.2 In-house 2-149 (318) alignment
Range on Protein: 22-167
Range on HMM: 2-149/318.0
VPVDNFAKHVHKLHKSDDRGFMIEYNKLDAGRE-FPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTT
..|.....||..|..| .  .  ||..|.  .| .    . .. ||||||| ||.||||.|| |...|.. |||||||..||||.. .||||.|.|.| |
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

FDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDE-TEEYGDIGVQ
..|||||||||.|| |||||...|| | |.|.|||.. ...||.. |.
ieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvve

subfamily_PTPRG_pd Subfamily PTPRG 22-168 8.7e-59 194.2 In-house 1-152 (563) alignment
Range on Protein: 22-168
Range on HMM: 1-152/563.0
VPVDNFAKHVHKLHKSDDRGFMIEYNK---LDAGREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGS-DYINASHIDGYNKPNAYIATQGPI
|||..||||| .|| ..| ||  |...     . ...... . . .|| |||| ||||||.||| |... .. .. |||||..||||.| .|.||||||.
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

PTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWP-DETEEYGDIGVQL
..||||||||.|||..| |||.|||.||.. ||. ||| ||.|.|| . |.|
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtl

subfamily_PTPRB_pd Subfamily PTPRB 20-168 2.8e-57 189.0 In-house 5-156 (293) alignment
Range on Protein: 20-168
Range on HMM: 5-156/293.0
PPVPVDNFAKHVHKLHKSDDRGFMIEYNKLDA-GREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIP
 |. ...|..||.|... .| .|. ||..| | |..  ...| .. |.||||| ||..|||||| |..... .|||||||..|.||| |. .||||||.|
kpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlp

TTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDE--TEEYGDIGVQL
.|.|||||||||..|  |||||.| |. | ||..|||..  .  |||| |.|
etvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtl

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 21-167 1.2e-55 183.8 In-house 4-151 (319) alignment
Range on Protein: 21-167
Range on HMM: 4-151/319.0
PVPVDNFAKHVHKLHKSDDRGFMIEYNKLDAGREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTT
...|.........|... ....  |...|. . ..  | | . .|| |||| ||.|||..|||| |...| ||||||||.||||.. ...||||.|. .|
eievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlent

FDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDET-EEYGDIGVQ
..||||||||..|  .||||.|.|. |.|..||||.|. |||| . |.
iedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivt

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 26-168 1.1e-54 180.7 In-house 13-160 (298) alignment
Range on Protein: 26-168
Range on HMM: 13-160/298.0
NFAKHVHKLHKSDDRGFMIEYNKLDAGRE----FPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTTF
 . | . . .| .  |.  |...|... .    .  .|| ...|| |||| .|.|.|.|||||.....   |||||||....|.. ||.||||.|...|.
alqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetv

DDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPD-ETEEYGDIGVQL
 ||||||.|.....|||||||.| .|.|.|||||| ..|.||.| |.|
edFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsl

0051299 (Phosphotyrosine protein) phosphatases II 19-166 1.8e-54 180.5 In-house 2-151 (288) alignment
Range on Protein: 19-166
Range on HMM: 2-151/288.0
HPPVPVDNFAKHVHKLHKSDDRGFMIEYNKLDAGR-EFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPI
. ...|....|.|.||....  |.. |...| .    ... .|.   |. |||| .|..||||||.|. ...| ||||||||.|||||.....|||||| 
dteisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPl

PTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWP-DETEEYGDIGV
|.|..|||||||||..  |||||.|.|. . ||..||| .....|||| |
pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditv

subfamily_PTPRA_pd Subfamily PTPRA 18-167 1.3e-53 177.0 In-house 10-161 (330) alignment
Range on Protein: 18-167
Range on HMM: 10-161/330.0
EHPPVPVDNFAKHVHKLHKSDDRGFMIEYNKLDAG-REFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGP
...|.||... . ...    | . |  |.| | ||  .  ...| . .|| |||. ||. ||.|||.|...| |  |||||||.||||.. . .||.|||
kyfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGP

IPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDET-EEYGDIGVQ
   | .|||||.|||.||.|||||.|.||.. ||..|||||    ||.| |.
keetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirve

subfamily_PTPRK_pd Subfamily PTPRK 19-168 2.5e-53 175.9 In-house 1-146 (314) alignment
Range on Protein: 19-168
Range on HMM: 1-146/314.0
HPPVPVDNFAKHVHKLHKSDDRGFMIEYNKLDAGrefpCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIP
|| . |..  ... .|....  ||  ||. |  |     |.| . .|..|||.|.|.|||.|||.|  |..   ||||||. ||.|..|.|.|.||||..
hpairvadllqsiallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlq

TTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDETEEYGDIGVQL
 |  ||||.|.....|||||||.|.|  ..|| ||||..|| |||| |.|
etvkdfWrlvydencasivmltelvevgrvkClkyWPedtevygdikvel

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 28-166 3.7e-53 175.5 In-house 3-144 (281) alignment
Range on Protein: 28-166
Range on HMM: 3-144/281.0
AKHVHKLHKSDDRGFMIEYNKLDA-GREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTTFDDFWR
 ||...|...|..||. ||.|| | |.. .   ... .|. |||| ||||||..||.... |.   .|||||....||.....|||||||.|.....||.
rkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWq

MVWEQQSASIVMLTNLQERHKLKCHKYWPDET--EEYGDIGV
|||||.   |||.|.  |  |||||.||||..   .|||. |
mvweqkvsaivmvtreieagklkChrYWPddnselkygdvtv

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 19-166 1.9e-52 173.2 In-house 3-150 (315) alignment
Range on Protein: 19-166
Range on HMM: 3-150/315.0
HPPVPVDNFAKHVHKLHKSDDRGFMIEYNKLDAGREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIP
| |.|.|..  .| . . |   ||  .|. .  |. .| ||| .. || |||| ||.|||.||| |  .||  .|||.||. ||||||.. |||.||| .
hqpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnv

TTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDETEEYGDIGV
.. .||||.|.|.. . ||||||| |..| |. |||||.   || | |
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviyGkitv

0043336 (Phosphotyrosine protein) phosphatases II 21-166 7.4e-52 171.9 In-house 1-146 (278) alignment
Range on Protein: 21-166
Range on HMM: 1-146/278.0
PVPVDNFAKHVHKLHKSDDRGFMIEYNKLDAGREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTT
|..| ...|.. .|.... .... |. .|.    .....|.  .|| |||| .|..||||||.|. .... .|||||||..||||.|...|||||| | |
pisvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpet

FDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDETEEYGDIGV
..||||||||... .|||||.| |... ||..|||.....|||. |
vedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftv

0040438 (Phosphotyrosine protein) phosphatases II 25-166 4.3e-51 169.4 In-house 3-145 (317) alignment
Range on Protein: 25-166
Range on HMM: 3-145/317.0
DNFAKHVHKLHKSDDRGFMIEYNKLDAGREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTTFDDF
 .. ... .|.||| .... |...|.     ...||.  .|| |||| .|. ||||||.|. .... .|||||||..||.|.....|||||| | |..||
ldlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedF

WRMVWEQQSASIVMLTNLQERHKLKCHKYWP-DETEEYGDIGV
|||||||.. .|||||.| |. . ||..||| .|| .|||. |
wrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftv

0050432 (Phosphotyrosine protein) phosphatases II 17-166 7.4e-51 168.7 In-house 21-170 (308) alignment
Range on Protein: 17-166
Range on HMM: 21-170/308.0
PEHPPVPVDNFAKHVHKlhKSDDRGFMIEYNKLDAGRE-FPCDVAYNSDNKAKNRYGNIVAYDHSRVVLneieNvRGSDYINASHIDGY--NKPNAYIAT
... ...|....|.. |  . |  ... |...| .  . ....||.  .|| |||| .|..||||||.|    .  ||||||||..|||  ..|...|||
vsslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIat

QGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDE----TEEYGDIGV
||| |.|..|||||||||..  |||||.|.|. . ||..|||.|    ..|||.. |
qgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftv

0039614 (Phosphotyrosine protein) phosphatases II 18-167 1.7e-49 164.3 In-house 10-159 (297) alignment
Range on Protein: 18-167
Range on HMM: 10-159/297.0
EHPPVPVDNFAKHVHKLHKSDDRGFMIEYNKLDAGREfPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENV-RGSDYINASHIDGYNK-PNAYIATQG
|..|.|.. .. .........  ... |. .|    . .. .|.   || |||| .|..||||||.|. ...|  .|||||||..|||.. ....|||||
esipiplsvldlllllekansktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqg

PIPTTFDDFWRMVWEQQSASIVMLTNLQERHKlKCHKYWPDETEEYGDIGVQ
| | |..|||||||||.. .|||||.| |. . ||..|||.|...|||. | 
PlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeeggtygdftvt

subfamily_Ptp69D_pd Subfamily Ptp69D 20-167 2.6e-49 163.0 In-house 2-151 (307) alignment
Range on Protein: 20-167
Range on HMM: 2-151/307.0
PPVPVDNFAKHVHKLHKSDDRGFMIEYNKLDA-GREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIP
.....|. .. ... ..  | |.. ||.|| |   .  . |. . .|. |||| .|.|.|. ||.|..|.    |||||||.| ||.. . .|| |.|. 
gaiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPve

TTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWP-DETEEYGDIGVQ
.| .|||||..||..  ||||.||.|  . ||.|||| ... .|||| |.
atigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvk

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 27-167 3.9e-49 162.3 In-house 9-151 (288) alignment
Range on Protein: 27-167
Range on HMM: 9-151/288.0
FaKHVHKLHKSDDRGFMIEYNKL-DAGREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTTFDDFW
  ..| | ....  ||  |||.|   ...   ... .. |. |||| ||..||. || |.. |...|.||||||.|||..| ..|||||||.. | .|||
v.akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfW

RMVWEQQSASIVMLTNLQERHKLKCHKYWPDETE--EYGDIGVQ
..|.|...  |||||.| |. | ||..||||. .  .||.. |.
elvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvt

0045450 (Phosphotyrosine protein) phosphatases II 15-163 4.3e-48 160.0 In-house 2-164 (307) alignment
Range on Protein: 15-163
Range on HMM: 2-164/307.0
NDPEHPPVPVDNFAKHVHKLHKSDDRGFMIEYNKLDAGREF---PCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENV-RGSDYINASHI--------D
. | ...... .. ..|..|....  |.  |..||     |   ....|.   || |||| .|..|||.||.|. ...   .|||||||..        |
dlplslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllld

GYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDEtE---EYGD
||......|||||| | |..|||||.|||..  |||||.| |. . ||..||||| .   .||.
gydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygn

0046845 (Phosphotyrosine protein) phosphatases II 43-166 5.8e-48 159.1 In-house 3-137 (284) alignment
Range on Protein: 43-166
Range on HMM: 3-137/284.0
MIEYNKLDAGREF---PCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENV-RGSDYINASHIDGY-----NKPNAYIATQGPIPTTFDDFWRMVWEQQS
. |. .|     .   ...||.   |. |||| .|..||||||.|. ...   .|||||||..|||     ......|||||| |.|..|||||||||..
eeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnv

ASIVMLTNLQERHKLKCHKYWPDE--TEEYGDIGV
  |||||.| |. . ||..|||.|  . .|||. |
rvIVmltelvengrekcaqYwplegevltygdftv

0047943 (Phosphotyrosine protein) phosphatases II 39-166 1.5e-47 157.8 In-house 11-139 (273) alignment
Range on Protein: 39-166
Range on HMM: 11-139/273.0
DRGFMIEYNKLDAGR-EFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLneieNVRGSDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIV
 .... |...|     .... ||.  .|| |||| .|..||||||.|    .  ||||||||..||||.....|||||| | |..|||||||||..  ||
ltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviV

MLTNLQERHKLKCHKYWPDE----TEEYGDIGV
|||.|.|... ||..|||.|    ...||.. |
mLtelvelgrekcaqYwpleggelsltygkftv

0036941 (Phosphotyrosine protein) phosphatases II 54-167 3e-47 156.7 In-house 28-140 (297) alignment
Range on Protein: 54-167
Range on HMM: 28-140/297.0
EFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLneieNVRGSDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKY
 ....|| . .|. |||| .|..|||.||.|    .  ||||||||..|||. ....|||||| |.|..|||||||||.. .|||||.| |. . ||..|
lgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqy

WP---DETEEYGDIGVQ
||   .|. .|||. |.
wpleegesltygdftvt

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 58-167 4.2e-47 155.5 In-house 2-111 (250) alignment
Range on Protein: 58-167
Range on HMM: 2-111/250.0
DVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLkCHKYWP-D
.|| . .|| |||| .|.|.|.|||||.. .  . |||||||...||.. .|.||||||...|. ||||||.|..|..|||||||.| .|  .|.||| .
svakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve

ETEEYGDIGVQ
..|.|||. |.
kaekyGdvtvs

DSPc_SM00195 45-167 9.9e-47 154.8 In-house 5-131 (263) alignment
Range on Protein: 45-167
Range on HMM: 5-131/263.0
EYNKLDAGR-EFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQ
|..||.. . . ... |  . ||.|||| ||. |||.|| |...|.  |||||||..|.|.||...||||||| |.|..||||||||...  |||||. .
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteee

ERHKLKCHKYWPDE---TEEYGDIGVQ
|..| ||..|||.|   .|..|.| |.
engkekcdrywpeesggketfgkisvk

PTPc_SM00194 45-167 9.9e-47 154.8 In-house 5-131 (263) alignment
Range on Protein: 45-167
Range on HMM: 5-131/263.0
EYNKLDAGR-EFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQ
|..||.. . . ... |  . ||.|||| ||. |||.|| |...|.  |||||||..|.|.||...||||||| |.|..||||||||...  |||||. .
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteee

ERHKLKCHKYWPDE---TEEYGDIGVQ
|..| ||..|||.|   .|..|.| |.
engkekcdrywpeesggketfgkisvk

subfamily_PTPN9_pd Subfamily PTPN9 27-167 1.6e-45 150.4 In-house 6-147 (297) alignment
Range on Protein: 27-167
Range on HMM: 6-147/297.0
FAKHVHklhKSDDRGFMIEYNKLDAGR-EFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTTFDDFW
. ..|.   . . || . || .. .   |   ...    |  |||| ... ||..||||.....   ||||||...|||....|.||||||.. |..|||
lvayvk...ekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfW

RMVWEQQSASIVMLTNLQERHKLKCHKYWPDE---TEEYGDIGVQ
||||||.   ||| | . || .||| .|||.|   ..|.||. |.
rmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvs

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 21-167 1.1e-43 144.5 In-house 3-151 (305) alignment
Range on Protein: 21-167
Range on HMM: 3-151/305.0
PVPVDNFAKHVHKLHKSDDRGFMIEYNKLDAGrEFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTT
.. .|..|..... .. .|.|.  .|..|    | ..||  .. ||||||. .|. .|..|. |.| |..  |||||||..|||.. ..||..|||...|
iialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlknt

FDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDETEE---YGDIGVQ
 .||||...| .  .|||||.|.|  | ||..|||... |   .|.. |.
vadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsve

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 22-168 5.5e-42 138.6 In-house 2-152 (290) alignment
Range on Protein: 22-168
Range on HMM: 2-152/290.0
VPVDNFAKHVHKLHKSDDRGFMIEYNKLDAG-REFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRG--SDYINASHIDGYNKPNAYIATQGPIP
.|||.|...| . |.  ..||  ....||.| .|.   |.  |.|| .||. ||| ||  |..|..| . .    .||||..|.||.. ..|||||||..
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

TTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDE-TEEYGDIGVQL
 |  |||...|..... |||||| .| .| ||..||||. |..|| . ..|
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikl

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 21-167 6.8e-42 138.4 In-house 2-149 (315) alignment
Range on Protein: 21-167
Range on HMM: 2-149/315.0
PVPVDNFAKHVHKLHKSddRGFMIEYNKLDAGREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTT
|.|| .|   | | ...    |  |.. |     ..  || ...|  ||||.||. .|..||.|. |..   |||||||.| .... .||||.||| ...
pipvaqfpafvnknrht..alfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkas

FDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPD---ETEEYGDIGVQ
 |||||||.... ..|||.|..||  |.|| .||||   .. |.| | |.
vddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikve

subfamily_PTPN6_pd Subfamily PTPN6 35-167 7.5e-42 138.4 In-house 21-159 (306) alignment
Range on Protein: 35-167
Range on HMM: 21-159/306.0
HKSDDRGFMIEYNKL---DAGREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNeIENVRGSDYINASHIDG--YNKPNAYIATQGPIPTTFDDFWRMVW
.. .  ||. |...|   .| . .  . .   .|| |||| ||. .||.||.|.  ..| |||||||. |..   .. ..|||||| ..||  |||||||
eslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvw

EQQSASIVMLTNLQERHKLKCHKYWPDET--EEYGDIGVQ
...|  |||.|.  || | || .|||||.  ||||.| |.
qensrvivmttkevErgkekCarYWPdeeekeeyGkisvt

0040439 (Phosphotyrosine protein) phosphatases II 56-166 1.4e-41 138.1 In-house 2-113 (249) alignment
Range on Protein: 56-166
Range on HMM: 2-113/249.0
PCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWP
...||.   || |||| .|..||||||.|. .... .|||||||.||||. ....|||||| | |..|||||.||... .|||||.|.|. . ||..|||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

-DETEEYGDIGV
 ... ||||. |
lggsleygdftv

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 20-160 1.6e-41 137.7 In-house 14-150 (319) alignment
Range on Protein: 20-160
Range on HMM: 14-150/319.0
PPVPVDNFAKHVHKLHKSDDRGFMIEYNKLDAGREFPCDVAYN--SDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPI
|..|. .  . ...  . | . . .|....       .| ..    .|| |||..||.|.|...| |. .. . .|||||||...|| ... |||.||| 
pdfpayyqqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPl

PTTFDDFWRMVWEQQSASIVMLTnlqerhKLKCHKYWPDETEE
. | .|||||.||.....||.||      | || .||| ....
dntladfWrmiweyncstivllt......kdkcsqywplkivi

Y_phosphatase Protein-tyrosine phosphatase 65-167 2.2e-41 137.2 Pfam-A 1-104 (235) alignment
Range on Protein: 65-167
Range on HMM: 1-104/235.0
NKAKNRYGNIVAYDHSRVVLneiENVRG-SDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWP---DETEE
|| |||| .|..||..|| |   ..  | ||||||....||......||||||.. |..|||||||.... .|||||.|.|... ||..|||   .|...
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGDIGVQ
|||| |.
ygdikve

Y_phosphatase Protein-tyrosine phosphatase 65-167 2.2e-41 137.2 In-house 1-104 (235) alignment
Range on Protein: 65-167
Range on HMM: 1-104/235.0
NKAKNRYGNIVAYDHSRVVLneiENVRG-SDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWP---DETEE
|| |||| .|..||..|| |   ..  | ||||||....||......||||||.. |..|||||||.... .|||||.|.|... ||..|||   .|...
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGDIGVQ
|||| |.
ygdikve

0042113 (Phosphotyrosine protein) phosphatases II 57-164 7.4e-41 135.6 In-house 1-109 (245) alignment
Range on Protein: 57-164
Range on HMM: 1-109/245.0
CDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWP-
..||.   || |||| .|..|||.||.|.....  .|||||||..|||. .. .|||||| | |..|||||.||... .|||||.. |... ||..||| 
ysvallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl

DETEEYGDI
.|. .|||.
gesltygdf

0045098 (Phosphotyrosine protein) phosphatases II 42-164 1.4e-40 134.8 In-house 10-121 (278) alignment
Range on Protein: 42-164
Range on HMM: 10-121/278.0
FMIEYNKLDAGREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVlneienvrgsDYINASHIDGYnkPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTN
... ...|  |    . .|   .|..|||| .|..||||||.          ||||||.||||  |...|||||| |.|..|||||.||... .|||||.
llefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmlte

LQERHKLKCHKYWPDET-EEYGDI
|.|. . ||..|||..  ..|||.
lvelgrekcaqywpeggsltygdf

subfamily_PTPN12_pd Subfamily PTPN12 47-161 2.8e-40 133.0 In-house 22-136 (290) alignment
Range on Protein: 47-161
Range on HMM: 22-136/290.0
NKLDAGREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERH
.|. | .... ... .. |..|||| .|. ||.|||.|..||.. |||||||..| | ... .|||.|||.|.| ||||||.||..   .||. .. |  
ekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelg

KLKCHKYWPDETEEY
| ||..|||.|.|| 
kkkCerYWpeegeee

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 21-166 3.5e-40 132.6 In-house 1-147 (515) alignment
Range on Protein: 21-166
Range on HMM: 1-147/515.0
PVPVDNFAKHVHKLHKSddRGFMIEYNKLDAGREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTT
|.|. .|   | |  .     |  |.. |     .|  || .  |  ||||.||. || .|| |. |..   |||.|||.| ...  .||||.||| ...
plplaqfPafvnknrht..tlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkas

FDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPD---ETEEYGDIGV
 |||||.|.... . |.|.|.|.|  | || |||||   .. ..| | |
vddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikv

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 63-160 4.3e-40 133.0 In-house 23-114 (284) alignment
Range on Protein: 63-160
Range on HMM: 23-114/284.0
SDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTnlqerhKLKCHKYWPDETEE
 .|| |||.|.|.|.|...| |. .  . .|||||||.| || ... ||||||| . | .|||||.||.....||.||      | || .||| ....
dqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 62-167 3.1e-39 129.6 In-house 5-111 (239) alignment
Range on Protein: 62-167
Range on HMM: 5-111/239.0
NSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYN-KPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDETEE
.  ||||||| |||.||||||||... |   |||||||..  |.  |.||||||| . ..  |||||.|... . ||||| | | || |||.|||| | .
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk

YGDIGVQ
| .. | 
ycnlrvt

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 63-167 3.8e-39 129.3 In-house 5-110 (239) alignment
Range on Protein: 63-167
Range on HMM: 5-110/239.0
SDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYN-KPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDETEEY
  ||||||| |||.||||||||... |   |||||||..  |.  |.||||||| . ..  |||||.|... . ||||| | | || |||.|||| | .|
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsky

GDIGVQ
 .. | 
cnlrvt

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 22-166 1.1e-38 127.9 In-house 2-145 (287) alignment
Range on Protein: 22-166
Range on HMM: 2-145/287.0
VPVDNFAKHVHKLHKSDDRGFMIEYNKLDAGREFPCDV--AYNSDNKAKNRYGNIVAYDHSRVVLNeienVRGSDYINASHIDGYNKPNAYIATQGPIPT
.||..|.. |.| |.  . ||.  .  |.   . . .|  .  |.|| |||. .|. .|  ||.|.     .  |||||..||||.. .|.|....|.  
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfn

TFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDET-EEYGDIGV
|  .||.......   ||||....| .. .|..|||.|.   .|.  .
tarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyni

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 18-167 1.3e-38 127.8 In-house 6-151 (297) alignment
Range on Protein: 18-167
Range on HMM: 6-151/297.0
EHPPVPVDNFAKHVHKLHKSDdrGFMIEYNKLDAGREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKpnAYIATQGPI
|  |.|. .||  | | ...|   | .|.. | .   .|  || .  |  |.|| ||. || ||| |. ...   |||.|||.. |...   .|.|| | 
errpiplsdfatlvqknrhtd..vfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPm

PTTFDDFWRMVWEQQSASIVMLTNLQERHKlKCHKYWPDET-EEYGDIGVQ
..| .|||.||...| . ||||....||.| || .||.|..  ..||. |.
katvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvv

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 24-167 1.1e-37 124.6 In-house 4-146 (439) alignment
Range on Protein: 24-167
Range on HMM: 4-146/439.0
VDNFAKHVHKLHKSDDRGFMIEYNKLDAGR-EFPCDVAY--NSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTT
 |.| .|| ||.| ..  |  ...|... . .. |. .   .. ...|||| ...|.||.||.|.||  |  | |||| .|.|| ... |||||||   |
rdefqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkket

FDDFWRMVWEQQSASIVMLTNLQERHKlkchkYWPDETEEY-GDIGVQ
 |||||.|.|.... ||||||| | .|     ||| ..| . ||| |.
tddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavr

subfamily_CG7180_pd Subfamily CG7180 55-167 4.6e-37 122.2 In-house 32-144 (296) alignment
Range on Protein: 55-167
Range on HMM: 32-144/296.0
FPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKlKCHKYW
  |  .....|. |||. ..| ||. ||||....    ||||||...|.. |...|| |..|   | |.|||.|..... ..|.||.  . .| ....||
gdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsyw

PDE-TEEYGDIGVQ
| .  |.||.| |.
pnkskeqygeifve

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 63-166 4.8e-37 122.4 In-house 1-105 (237) alignment
Range on Protein: 63-166
Range on HMM: 1-105/237.0
SDNKAKNRYGNIVAYDHSRVVLNEIENvrGSDYINASHIDGYN-KPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDE--TE
|.||.|||||||||||||||||.   .  |||||||....|..  |. |||.|||. .. ||||.|||... . ||||| | |. .||||||||.    .
senkiknrygnivaydhsrvvlkgags..gsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpa

EYGDIGV
 || . |
aygvltv

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 32-161 8.9e-37 121.4 In-house 8-141 (301) alignment
Range on Protein: 32-161
Range on HMM: 8-141/301.0
HKLHKSDDRgFMIEYNKLDAGREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIEN--VRGSDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVW
|.  |  .. |  .|..|. |.. .|.| ....||| ||. ||. ||. |..|.. .|  .   .|||||.||||.. ...||.|||.  |  ||||..|
hvaakhsnk.feeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliw

EQQSASIVMLTNLQERHKLKCHKYWPDETEE---Y
... .||||.|||.|. | ||..|||. ..|   .
qekpvsivmvtnlkegtkskceqywpnseaeseef

0037934 (Phosphotyrosine protein) phosphatases II 57-167 1.2e-36 121.9 In-house 2-106 (243) alignment
Range on Protein: 57-167
Range on HMM: 2-106/243.0
CDVAYNSDNKAKNRYGNIVAYDHSRVVLneienvRGSDYINASHIDGYNKpnaYIATQGPIPTTFDD----FWRMVWEQQSASIVMLTNLQERHKLKCHK
. .|    |. |||| .|..||||||.|       |||||||..|.....   .|||||| | |..|    ||||.||... .|||||.|.|. ..||..
fsiallpenlsknrysdilpydhsrvkl......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPDETeEYGDIGVQ
|||.|. .|||. |.
ywpgev.tygdftvt

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 23-167 1.3e-36 121.3 In-house 6-152 (325) alignment
Range on Protein: 23-167
Range on HMM: 6-152/325.0
PVDNFAKHVHKLHKSDDRGFMIEYNKLDAGREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTTFD
 | |. .||.| .  |. ||  |.. | .       ||   .||||||. |.||.|.|||||.  ..   |||||||..  . | . ..|.| | ..| .
avvnlvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatin

DFWRMVWEQQsASIVMLTNLQERHKLKCHKYWPDE---TEEYGDIGVQ
|.||.| . . .|.|...|  .  | .| .|||.|   . ..| . |.
dlWrlvldWr.csvvvvlneldlgkdrcavywpkemgksktfGglevk

subfamily_PTPN1_pd Subfamily PTPN1 52-159 1.7e-36 120.5 In-house 19-122 (290) alignment
Range on Protein: 52-159
Range on HMM: 19-122/290.0
GREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENvrgsDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCH
 ..||. .| .  |...||| ..  |||||..|.. .|    |||||| ..  .    || ||||.| | | ||.|||||.| ..||| .. |....||.
asdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikca

KYWPDETE
.||| . |
qywPqgee

subfamily_PTPN3_pd Subfamily PTPN3 53-163 2.7e-36 119.9 In-house 29-141 (280) alignment
Range on Protein: 53-163
Range on HMM: 29-141/280.0
REFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENvrgsDYINASHI----DGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKL
..  ...|  ..| .|||| .|..||. || |.| |.    |||||...    .. .  | |||||||...|  |||.|||||.|  |||||.| || . 
pglaisaarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrv

KCHKYWPDETEE--YGD
|||.|||....|  ||.
kChqyWPetedeleyge

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 64-166 5.2e-36 119.1 In-house 27-136 (274) alignment
Range on Protein: 64-166
Range on HMM: 27-136/274.0
DNKAKNRYGNIVAYDHSRVVLN-EIENVRGSDYINASHIDGYN-KPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDETEE-
 .. |||| .|.  ..|||.|. |  .   |.|||| .| ||. . .||.|||||.|.| .|||||......  |||||.|.|... ||..|.||...  
gsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedye

----YGDIGV
    |||. .
iserygdvei

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 60-157 1.6e-34 114.0 In-house 33-129 (287) alignment
Range on Protein: 60-157
Range on HMM: 33-129/287.0
AYNSDNKAKNRYGNIVAYDHSRVVLNEiENVRGSDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDE
| .  .  ||||.... .|..||.| . |   ||||||| .. .|.. .|.||.||||..|  ||||.|.|..|||....|   |  .|||.||||. 
aeelaavkknryadvlPiddtrvllsa.egelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 46-162 2.2e-34 113.7 In-house 1-118 (270) alignment
Range on Protein: 46-162
Range on HMM: 1-118/270.0
YNKLDAGREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYN-KPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQE
...|| ... . |.     .|. ||| .|.   ..||.|.|.|.   . |||| .. |.. ....|||..|| |||  .||||.||... .|||.|.|.|
fkeldkeetsesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleE

RHKLKCHKYWPDETEEYG
. . || .||| |..|  
kgrkkCerYWpaepkekv

subfamily_PTPN13_pd Subfamily PTPN13 55-159 2.3e-34 113.9 In-house 27-128 (273) alignment
Range on Protein: 55-159
Range on HMM: 27-128/273.0
FPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENvrgsdYINASHIDGYN--KPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHK
  |.|. . .||.|||| |.. ||..|| |..  .     |||||.|      .   |||.|||.|.| .|||.|||||..  |.|.|. .|. |.|||.
dtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchr

YWPDETE
|||....
ywPeskn

subfamily_PTPN23_pd Subfamily PTPN23 59-166 2.2e-33 110.3 In-house 37-144 (288) alignment
Range on Protein: 59-166
Range on HMM: 37-144/288.0
VAYNSDNKAKNRYGNIVAYDHSRVVLNeienVRGSDYINASHIDGYN-KPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDE
.|    .  |||. .|. |||.||.|.        ||||||.. .       .||||.|...|  |||.||.||.|  ||||.. .|..| |...||| .
iaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPed

---TEEYGDIGV
   |...||. |
kgetvkfgdlsv

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 21-157 2.5e-33 110.0 In-house 3-145 (392) alignment
Range on Protein: 21-157
Range on HMM: 3-145/392.0
PVPVDNFAKHVHKLHKSddRGFMIEYNKLDAGREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTT
|.|| .|   |.| ..|    |. |.  |     .|  || . .|. ||||.||. || .||.|. |...  |||.|||.|....  .||||.||| ...
pipvaqfpafveknrhs..alffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaas

FDDFWRMVWEQQSASIVMLTNLQERHKL----KCHKY----WPDE
.|||||||.... ..|.|.|.|.|  |      . ..    |||.
lddfwrmvfqenvttiamvtklkegdkgddartvaqfhftewPdk

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 53-167 9.6e-33 108.3 In-house 21-135 (283) alignment
Range on Protein: 53-167
Range on HMM: 21-135/283.0
REFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENvrgsDYINASHID---GYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLK
 . ..|.| ...|| |||. .||..|  || |.   .    |||||..|     |.. . ||..|.|.  |  |||.||.... ..|||||.|||  . |
pdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrik

CHKYWPDE-TEEYGDIGVQ
| .||| . .|.||.  | 
CsqyWPkrGsedyGeftvt

subfamily_PTPN14_pd Subfamily PTPN14 26-160 1.3e-32 108.1 In-house 11-145 (300) alignment
Range on Protein: 26-160
Range on HMM: 11-145/300.0
NFAKHVHKlhKSDDRGFMIEYNKLDAGRE-FPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVrGSDYINASHIDGY--NKPNAYIATQGPIPTTFD
. ||...|  | ..     ||...   ||   ...| . .|. |||. ... |...|| |.  ..   ..|||||.|      |   ||..|||...|  
krakilek..kleegkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvq

DFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDETEE
|||.|||||. . |||||. .|  | |..||.|.....
dfWqmvWeqgvqlivmlteeeedgkeksfkyfPklesk

subfamily_ptpA1_pd Subfamily ptpA1 26-157 5.2e-32 106.1 In-house 12-138 (418) alignment
Range on Protein: 26-157
Range on HMM: 12-138/418.0
NFAKHVHKLHKSDDRGFMIEyNKLDAGREFPCDvayNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGyNKPNAYIATQGPIPTTFDDFW
|. .|.. .||  .   ..| . .        |   .  | .|||| ||.  .|.|| |..|..  ||||||| .|||   |. .|.||||.| |  |||
nlknhikcihkikeefrlle.esvgpsetsegd...kkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfw

RMVWEQQSASIVMLTNLQERHKLKCHKYWPDE
|||||..   ||||.   |  ..|| .|||..
rmvwenrcriivmlsresencrikcdrywpeq

subfamily_PTPRN_pd Subfamily PTPRN 56-160 6.8e-32 105.4 In-house 47-152 (297) alignment
Range on Protein: 56-160
Range on HMM: 47-152/297.0
PCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHID-GYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYW
 ..|| . .|  |||. ....|||||| |.|  .   ||||||| |     .  ||||||||...|  |||.||||| .. ||.||.|.|    .|..||
tkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckryw

PDETEE
||| .|
pdeGse

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 65-160 1.5e-27 91.2 In-house 33-128 (297) alignment
Range on Protein: 65-160
Range on HMM: 33-128/297.0
NKAKNRYGNIVAYDHSRVVLNEieNVRGSDYINASHIDGYNKP--NAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDETEE
   |||| .|.|.| .|| |     . ..||||| ..   ...    || .|||. .| ||||..|.||.   |||...|||  . ||  |||.  .|
slrknryrdilatddtrvkllr..viterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqe

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 64-166 9.3e-26 85.4 In-house 46-160 (350) alignment
Range on Protein: 64-166
Range on HMM: 46-160/350.0
DNKAKNRYGNIVAYDHSRVVLN--------EIENVRGSDYINASHIDGY-----NKPNA-YIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLK
.  ||||| ||. |.|||| |.            ....|||||...         .|.  |||||.|.| |.|||.... . .   |..||...|    |
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek

CHKYWPDEteEYGDIGV
|..||..   .| || |
cyrYWqeg..sydditv

0049772 (Phosphotyrosine protein) phosphatases II 53-155 1.1e-25 86.5 In-house 34-164 (314) alignment
Range on Protein: 53-155
Range on HMM: 34-164/314.0
REFPCDVAYNSDNKAKNRYGNIVAYDhSRVVLnEIENVRGSDYINASHIDGYnkpNAYIATQGPIPTTFDDF----------WRMV--WEQQSASIVM--
.|. . ||.   |. |||| .|. .| .||.|   ..|.||||||||..||.   ...|||||| . |..||          ||||  .....  |||  
peltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsr

-------------------LTNLQERHklkchK-----YWP
                   |..| ...           ...
devladelsrLdaAlgKtpllildgng.....neptaadle

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 38-166 1.2e-24 81.5 In-house 25-154 (310) alignment
Range on Protein: 38-166
Range on HMM: 25-154/310.0
DDRGFMIEYNKLDAGREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLnEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIV
   |.. .| |||| ..         ..  |||| ..|  | ||| | .|.. |  ||| | ..      ...| .|||.  |  |||||...... ||.
gieglvkqyrkldakqdssltyeaykkymhknrysdvvcldtsrvkl.kidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesil

MLTNLQERHKLKCHKYWPD--ETEEYGDIGV
.| .  |  . ||  |||    || || | |
llckvgeegrpkcvgywpslgvtetygcirv

0041856 (Phosphotyrosine protein) phosphatases II 65-161 2.7e-24 81.2 In-house 1-78 (182) alignment
Range on Protein: 65-161
Range on HMM: 1-78/182.0
NKAKNRYGNIVAYDHSRvvlneienvrGSDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTnlqerhklkCHKYWPDETEEY
|. |||| .|. |||||          ..|||||. ..|. ... .|||||| . |. ||.||..|..  .||.||         .. |||.. | .
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpellerl

subfamily_CG42327_pd Subfamily CG42327 64-167 9.4e-24 78.6 In-house 27-136 (319) alignment
Range on Protein: 64-167
Range on HMM: 27-136/319.0
DNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYN-KPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWP-----DE
  | |.|. |.|   ..||||..| .   . |..||.. ||.  || |||.| .   .  ||||.||||||  || ||.|.|    .| .|.|     |.
tskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldn

TEEYGDIGVQ
|. |||| | 
tslyGdilvt

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 62-158 1.3e-22 75.2 In-house 38-132 (307) alignment
Range on Protein: 62-158
Range on HMM: 38-132/307.0
NSDNKAKNRYGNIVAYDHSRVVLNEieNVRGSDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDET
 | |  |||| .. . |..|.|..   .   |||| | ..    ||. .|..|||  .|  .|| |. ...  |..|| .. |  |.||..||| | 
fsantdknryqdvkcqdkgrivvkf..dglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywplee

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 63-160 2.2e-22 74.1 In-house 54-146 (290) alignment
Range on Protein: 63-160
Range on HMM: 54-146/290.0
SDNKAKNRYGNIVAYDHSRVVLNEIENvrgSDYINASHIDGYNKPnaYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDETEE
  .  |||| ..|  | .||.|..  .    ||. | ...| . .  .| |||..  |  |.|||| ... | |||| .| |  | ||..|.|..  |
ntefkknrykdvvcndktrvilkdGyd...GdyvhanyvkGlkam..filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGe

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 57-157 3.3e-22 73.5 In-house 29-130 (281) alignment
Range on Protein: 57-157
Range on HMM: 29-130/281.0
CDVAYNSDNKAKNRYGNIVAYDHSRVVLNE-IENVRGSDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWP
| |  .  |. |||| || . | ||| |.  . |   .||| | .|        || ||||   |  |||||.|......|||| .. |  . || .|.|
ctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfp

DE
 .
rn

subfamily_egg_pd Subfamily egg 26-159 9.1e-22 72.1 In-house 4-132 (307) alignment
Range on Protein: 26-159
Range on HMM: 4-132/307.0
NFAKHVHKLHKSDDRGFMIEYNKLDagrEFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDGYNKPNAYIATQGPIPTTFDDFW
..||.. .. .  .| ...  .  |   | .   |....|. | |   .   | ||| |.  .     |.| | ...|    | .| .| |.  | ||||
kkakylseivqelerrlevleesvd...eislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfw

RMVWEQQSASIVMLTNLQERhkLKCHKYWPDETE
|||....   |||||  .|    .|. |||   .
rmvfqeevqyivmltsrkes..erceyywpkaes

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 57-163 2.2e-20 67.8 In-house 25-127 (267) alignment
Range on Protein: 57-163
Range on HMM: 25-127/267.0
CDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVrgsdYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHklkCHKYWPD
.   . ..|...||. . . ||..||.| . |.     |||||...||.. ||.|.||.|.  |  ||. .. .|. . ||.||.  .      ...|| 
isqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdn...irlfwPP

E---TEEYGD
.   ...| |
kmgqakkyqd

0051429 (Phosphotyrosine protein) phosphatases II 92-160 2.5e-20 68.7 In-house 3-86 (272) alignment
Range on Protein: 92-160
Range on HMM: 3-86/272.0
GSDYINASHIDGYNK---PNAYIATQGPIPTTFDDFWRMvWEQQSASIVMLTNLQERHKLKCHKYWP-------------DETEE
 |.||||....||..   |.......|| | | .||||. .|..  .||.|... || .|||..|||             ..| .
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptil

0036282 (Phosphotyrosine protein) phosphatases II 92-166 6e-19 63.8 In-house 1-70 (174) alignment
Range on Protein: 92-166
Range on HMM: 1-70/174.0
GSDYINASHIDGYNKPNAYIATQGPIPttfddFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDETEEYGDIGV
||||||||..|..  .. .||.||| .     ||.|..|... ..|||....|... ||. |||.  | . . |.
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpelredlerlgi

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 61-160 2e-18 61.1 In-house 51-148 (305) alignment
Range on Protein: 61-160
Range on HMM: 51-148/305.0
YNSDNKAKNRYGNIVAYDHSRVVLNEIEnvrGSDYINASHIDGYNKPN-AYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDETE
 .  ...|||| .. . |.| | |..      |||| | ..     |.  .|..|||.  | |.|| || ...   |||| .  |  |||| .|||    
sadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqg

E
|
e

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 19-115 2.3e-18 60.2 In-house 2-95 (95) alignment
Range on Protein: 19-115
Range on HMM: 2-95/95.0
HPPVPVDNFAKHVHKLHKSDDRGFMIEYNKLDAGREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNeieNVRGSDYINASHIDGYNKPNAYIATQG
  |. |  |  || ..|   |. |  |.. .      |  |     |  |||. ||. || .||||      | ||||||  .||| . |.|||.||
fkpihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlt...tkrdsdyinacfvdgyarkncyiaaqg

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 37-158 3.6e-18 60.4 In-house 19-138 (305) alignment
Range on Protein: 37-158
Range on HMM: 19-138/305.0
SDDRGFMIEYNKLDAGREFPCDVAY-NSDNKAKNRYGNIVAYDHSRVVLneiENVRGSDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSAS
   .|.  |.. .    .|    |. ..... |||| ..   |. || |   |.    .|| | ..    .|. .| || |.  |  ||| | ....  .
kgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkvea

IVMLTNLQERHKLKCHKYWPDET
| || ||.|.   ||..|.. . 
ifmlcnllekgakkcleyfaskd

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 57-161 7.2e-18 59.5 In-house 27-128 (285) alignment
Range on Protein: 57-161
Range on HMM: 27-128/285.0
CD-VAYNsDNKAKNRYGNIVAYDHSRVVLNEIEnvrgSDYINASHIDGYNKP-NAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYW
|   ||.  |   ||| .. . . .||||.. .     ||| || .    |  ..||.||||.| |. |||.|..... | ..||  | |    ||  |.
ctytaye.anpdlnryadvrcieetrvvlknhd....rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyy

PDETEEY
|..  | 
peklgev

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 21-103 1.6e-17 57.9 In-house 5-85 (440) alignment
Range on Protein: 21-103
Range on HMM: 5-85/440.0
PVPVDNFAKHVHKLHKSddRGFMIEYNKLDAGREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINASHIDG
|. | .|| .|.. ..|  | |  |.. | .|   |.|.|   .|| |||| ||.|||||||.|.|.. |  |||||||.|.|
piivadfadyvqnnrrs..rafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasying

0046846 (Phosphotyrosine protein) phosphatases II 89-160 1.9e-17 59.0 In-house 8-75 (176) alignment
Range on Protein: 89-160
Range on HMM: 8-75/176.0
NVRGSDYINASHIDGYnkpnAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDETEE
   ..|||||. |.|.    ..||||||.| |. ||..|..|..   .|.||...| ..|||. |||.....
ldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpelekl

0043147 (Phosphotyrosine protein) phosphatases II 92-156 4.3e-17 57.8 In-house 4-75 (172) alignment
Range on Protein: 92-156
Range on HMM: 4-75/172.0
GSDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQER-------HKLKCHKYWPD
||||||||..|.| .|. .|||||| . |..|||||..|..   ||.||.|.             .. .|||
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpD

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 65-167 3.4e-16 53.5 In-house 48-164 (349) alignment
Range on Protein: 65-167
Range on HMM: 48-164/349.0
NKAKNRYGNIVAYDHSRVVLNEI--------------ENVRGSDYINASHI--DGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKL
  ||||| .|. |.||||.|..               .  .  ||||| ..    ..  . ||||| |.|.| |||....  ..   .. |.. .|    
lfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsle

KCHKYWPDEteEYGDIGVQ
||..|| .   .| .| |.
kcdiywqel..sysnitvk

0049260 (Phosphotyrosine protein) phosphatases II 101-154 1.1e-15 53.1 In-house 2-55 (152) alignment
Range on Protein: 101-154
Range on HMM: 2-55/152.0
IDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYW
||||..|...|||||| | |..|||||..|..   |||||.|.|..||||..|.
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi

0044763 (Phosphotyrosine protein) phosphatases II 77-158 2.1e-15 52.3 In-house 2-74 (178) alignment
Range on Protein: 77-158
Range on HMM: 2-74/178.0
YDHSRVVLNEIENVRGSDYINASHIDGYnkpnAYIATQGPipttfDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDET
.|..||.|...|.. .|||||||.|...     |.....|      |......|.   .||.||. .|...|||..|||.|.
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeea

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 66-165 2.2e-15 51.2 In-house 51-147 (301) alignment
Range on Protein: 66-165
Range on HMM: 51-147/301.0
KAKNRYGNIVAYDHSRVvlNEIENVRGSdYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDETEEYGDIG
| |.|| ..    .. |  . |.. .    | |  |.   .|. .||||||.. | .||| |.   .   ||||..  |... ||..| | ...|  |||
kdkhryptvPckPstav..evivdGkrv.PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldig





subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 60-157 5.2e-15 49.7 In-house 91-181 (244) alignment
Range on Protein: 60-157
Range on HMM: 91-181/244.0
AYNSDNKAKNRYGNIVAYDHSRVVLNEieNVRGSDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHklkchKYWPDE
|.| .|  ||| |  . .| .|| |..     |  ||||| .    .   || || |.  |  |||.|. |.    .|.|  ..|       .|||| 
afnpnnswknregaglpfdfnrvplsk..gsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed.....eywpds

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 66-156 3.4e-14 47.2 In-house 44-130 (312) alignment
Range on Protein: 66-156
Range on HMM: 44-130/312.0
KAKNRYGNIVAYDHSRVVLNEIENVrgsdYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPD
|  ||| ||  .|  |  |   ||     || |  .    ||. ...||||.  |   ||...    |.||..|. . |    || ||  |
kdlnrypniqcwdrgrftlagdenf....yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisd

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 64-151 3.5e-14 47.0 In-house 33-119 (332) alignment
Range on Protein: 64-151
Range on HMM: 33-119/332.0
DNKAKNRYGNIVAYDHSRVVLNEIENvrGSDYINASHIDGYNKPNAYIATQGPIPT-TFDDFWRMVWEQQSASIVMLTNLQERHKLKCH
.|   ||   . ..||||| |   .     |. ||| .|||.| .||| .| |.   |   ||||| |.. . |... ...|..| |. 
nnmdmnriphlycfdhsrvelapqdg..kddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkap

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 64-159 9.4e-14 46.1 In-house 42-133 (288) alignment
Range on Protein: 64-159
Range on HMM: 42-133/288.0
DNKAKNRYGNIVAYDHSRVVLNeienvRGSD-YINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDETE
.| ...|| |.   | .|| |.       .| ||.|  .   . ..  | .| |. .| . .|.|. |..   ||||..| |. | |  .|.| .  
anptrdryenlprcditrvkls.....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklG

subfamily_eak_pd Subfamily eak 63-161 1.5e-13 44.9 In-house 50-146 (332) alignment
Range on Protein: 63-161
Range on HMM: 50-146/332.0
SDNKAKNrYGNIVAYDHSRVVLNEIENVRgSDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDETEEY
 ..  .|   .|| ||.  | |      |   ||||| ..  .  . || |  .  .    ||.|| ||.| .||.| .  | .  |  ||.||.| | 
leavnrn.vvkivpydrylvrltssqlnr.lGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktree

0051082 (Phosphotyrosine protein) phosphatases II 93-161 4.4e-13 44.6 In-house 3-60 (151) alignment
Range on Protein: 93-161
Range on HMM: 3-60/151.0
SDYINASHIDGYnkpnaYIATQGPIPttfdDFWRMVWEQQSASIVMLTNLQERHklKCHKYWPDETEEY
|||||.| ..|.     .....|| .    ||.....|..  .||.|....||   .|..|.|..  |.
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelgiev

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 64-141 6.3e-13 42.9 In-house 36-118 (347) alignment
Range on Protein: 64-141
Range on HMM: 36-118/347.0
DNKAKNRYGNIVAYDHSRVVLNeIEN---VRG---SDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTN
 . .|||  .    | .||||   |.    |      |||||||   |  . || || |.| |  |||.||   . . .| . .
kslsknrskdvklidatrvvls.peksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtife

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 101-159 1.6e-12 41.5 In-house 229-284 (440) alignment
Range on Protein: 101-159
Range on HMM: 229-284/440.0
IDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERhklKCHKYWPDETE
..|| | ||.|||| |. .|  ||||.| . . ..|.|| .|...    |  ||| .| 
fegyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntr

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 64-155 2.3e-12 41.1 In-house 46-130 (303) alignment
Range on Protein: 64-155
Range on HMM: 46-130/303.0
DNKAKNRYGNIVAYDHSRVVLNEienvrgSDYINASHIDGYNKpNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWP
.|  |||. ...  |||.| | .      | || ||...   . .  | || |.. |  |||.|. ||.   ...|    | .||  .  .|
knmdknrfvdvicldhskvklsd......ssyihasyleldss.kkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfp

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 109-163 4.8e-11 37.2 In-house 6-60 (199) alignment
Range on Protein: 109-163
Range on HMM: 6-60/199.0
AYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDETEEYGD
 ||||| |.  |. |||.||||  |  |||. . |  ..     |||      | 
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgk

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 109-163 5.2e-11 37.1 In-house 5-59 (198) alignment
Range on Protein: 109-163
Range on HMM: 5-59/198.0
AYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDETEEYGD
 ||||| |.  |. |||.||||  |  |||. . |  ..     |||      | 
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgk

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 59-156 2.6e-10 33.5 In-house 21-86 (169) alignment
Range on Protein: 59-156
Range on HMM: 21-86/169.0
VAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINAshidgynkpnayiatqgpipttfddfwRMVWEQQSASIVMLTNLQERHklkchKYWPD
.|  . |..|||    .|  | || |. . .  |||||||                           ||.|| ... ||.| . ...       .||.
maeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddkn.....nfwpe

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 64-163 2.8e-10 34.1 In-house 50-147 (302) alignment
Range on Protein: 64-163
Range on HMM: 50-147/302.0
DNKAKNRYGNIVAYDHSRVVLNEienvRGSDYINASHIDGYNKPNAYIATQGPIPTTF---DDFWRMVWEQQSASIVMLTNLQERHKlKCHKYWPDETEE
.| .||.  .. ..|. .| |..    .  .|.|||...  .  .  | .| |. ..    ..|||||.... .|.|.|   .| .|   ....| ....
knlkknqsedvpildsnlvklea....epdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgd

YGD
| .
yke

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 59-156 3.4e-10 33.0 In-house 20-85 (169) alignment
Range on Protein: 59-156
Range on HMM: 20-85/169.0
VAYNSDNKAKNRYGNIVAYDHSRVVLNEIENVRGSDYINAshidgynkpnayiatqgpipttfddfwRMVWEQQSASIVMLTNLQERHklkchKYWPD
.|  . |..|||    .|  | || |. . .  |||||||                           ||.|| ... ||.| . ...       .||.
maeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddkn.....nfwpe

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 50-104 5e-09 30.1 In-house 24-77 (244) alignment
Range on Protein: 50-104
Range on HMM: 24-77/244.0
DAGREFPCDVAYNSDNKAKNRYGNIVAYDHSRVVLNEIeNVRGSDYINASHIDGY
|  |||    |  | | .|||| ||. .|..||.|.   .  |||||||..|.| 
dhtreflqtnavlsanatknryinilpfdetrvilsss.kkegsdyinanyiqgs

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 86-157 9.6e-09 29.6 In-house 6-72 (130) alignment
Range on Protein: 86-157
Range on HMM: 6-72/130.0
EIENVRGSDYINASHIDGYNKPNAYIATQGPIPTTFDDFWRMVWEQQSASIVMLTNLQERHklkchKYWPDE
|.. ..| .||||| .   .. . |. || |.  |  |||.|. |.    .|.|  ..|       .|||| 
evsrlqgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed.....eywpds

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 66-160 2.6e-08 28.4 In-house 20-123 (290) alignment
Range on Protein: 66-160
Range on HMM: 20-123/290.0
KAKNRYGNIVAyDHSRVVLNEIENVRGSDYINASHIDgYNKPNAYIATQGPIPT-------TFDDFWRMVWEQQSASIVMLTNLQERHKL----KCHKYW
. ..|. . ..  ..||||..  .   .||| |...  . .  . |.|| |          |  .|| |. . .. ..||| . .|...      | || 
emdqRlevpLv.eatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYv

PDETEE
|.. .|
pesvge

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 108-160 8.9e-08 26.5 In-house 35-80 (255) alignment
Range on Protein: 108-160
Range on HMM: 35-80/255.0
NAYIAtqgpiptTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDETEE
| |.        | | |....  ...  .|||....|  . ||..|.| | .|
nlysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekde

subfamily_hpo-7_pd Subfamily hpo-7 117-160 9.4e-07 23.0 In-house 43-86 (263) alignment
Range on Protein: 117-160
Range on HMM: 43-86/263.0
IPTTFDDFWRMVWEQQSASIVMLTNLQERHKLKCHKYWPDETEE
.  | | |....  ...  .|||.. .|  . || .|.| | .|
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekde