Gene PTPN1 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN1
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP071_AA protein Get Run
NvecP071_AA_44-301 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN1_pd Subfamily PTPN1 41-304 1.2e-133 439.3 In-house 12-274 (290) alignment 
Range on Protein: 41-304
Range on HMM: 12-274/290.0
NWQSRENAG--KVAAAKLPANRPLNRYRDVLPYDHSRIILESTQNgtDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKN
 .. |..|   ....||||.||.||||||| |||||||.||...|  |||||.|||..|. ..|||.|||||.|.|||||||||..||||.|||||.||.
yldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn..dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvveke

QIKCFQYWPCGERyahVNCLELD--SFQIKYITENRSEEFTVRILELENKKTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAGVLSSDVGPAVI
||||.||||.||.   ...|.|.  ....|.|.|.|....|||.|||||.||.|||...|.||.||||||||..|..||.|||..|..|.||||||||||
qikcaqywPqgee...ekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavi

HCSAGIGRSGTFVMIDSILAEVEATGNLNAVDLGERLLAARQYRVGLIQTPDQLRFTSIAILEGTLAL
||||||||||||...|..|...|....|..||. ..||..|.||.|||||.|||||...|||||.  .
hcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvi
0050432 (Phosphotyrosine protein) phosphatases II 45-299 2.7e-85 281.7 In-house 54-297 (308) alignment 
Range on Protein: 45-299
Range on HMM: 54-297/308.0
RENAGKVAAAKLPANRPLNRYRDVLPYDHSRIILestQNGTDYINANLVEFP--ELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKC
  . ..  .|.||.|...|||.|.|||||||..|   ..|.|||||..| ..   | ...|..|||||.| ..||.||||.|.. ..||.| .|....||
vkplleysvallpenkdkNrykdilpydhsRVkl...degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekc

FQYWPCGERYahvNCLELDSFQIKYITENRSEEFTVRILELENKKTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAGvlSSdvGPAVIHCSAGI
.||||  .     ..|| . |..... |   ...||| |||.|....|.|.|.|.||..|||.|||  |  .|.|| ..|.    ..  || |.|||||.
aqYwplelgg...gsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl..pg..gpivVHCsaGv

GRSGTFVMIDSILAEVEATgnlNAVDLGERLLAARQYRVGLIQTPDQLRFTSIAILE
||.|||...| .|  .|..   . ||. | .   |..| | .|||.|..|   |.||
GRtGtfialdllleqleke...ggvdvfeavkklReqRpgmvqtpeqylflyralle
0036941 (Phosphotyrosine protein) phosphatases II 45-300 1.4e-83 275.9 In-house 25-276 (297) alignment 
Range on Protein: 45-300
Range on HMM: 25-276/297.0
RENAGKVAAAKLPANRPLNRYRDVLPYDHSRIILesTQNGTDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQ
. . |.  .|.||.|...|||.|.|||||.|..|  ...|.|||||..|....|....|..|||||.| ..||.||||.|.. ..||....|.. .||.|
llllgslsvallpenleknRykdilpydhtRVkl..ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaq

YWPCG-ERYAHVnclelDSFQIKYITENR--SEEFTVRILELENKKTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAGVLSSDVGPAVIHCSAG
|||   . .  .     . |........   ....|.| ||.......|.|.|.|.||..|||.|||  | ..|.|. ..|..  |. . || ..|||||
ywpleegeslty.....gdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaG

IGRSGTFVMIDSILAEVEATGNLNAVDLGERLLAARQYRVGLIQTPDQLRFTSIAILEG
.||||||...| .|  .|     . ||. | ..  |..| | .||..|.||   |.|| 
vgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallel
0051299 (Phosphotyrosine protein) phosphatases II 49-299 3e-82 271.6 In-house 39-284 (288) alignment 
Range on Protein: 49-299
Range on HMM: 39-284/288.0
GKVAAAKLPANRPLNRYRDVLPYDHSRIILESTQN--GTDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYW
... ||.||.|.. |||.|.|||||||..| ....  |.|||||.......|....|..|||||.| ..||.||||.|.. ..||.|..|....||.|||
ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYw

PCgeryahVNCLELDSFQIKYITENRSEEFTVRILELENK----KTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAGVlsSDVGPAVIHCSAGI
|        ..|... ...... |   ...||| ||..|.    ...|.| |.|.||..|||.|||  |  .|.|| ..|.|    |. || |.|||||.
pl......ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala..sgggpvvVHCsaGv

GRSGTFVMIDSILAEVEATgnlNAVDLGERLLAARQYRVGLIQTPDQLRFTSIAILE
||.|||...| .|  .|..   . ||. | .   |..| |..|||.|.||   |.||
gRtgtfialdllleqleke...ggvdvleavkrlreqRpgmvqtpeqyrfvyealle
0046845 (Phosphotyrosine protein) phosphatases II 49-299 4e-82 271.1 In-house 18-272 (284) alignment 
Range on Protein: 49-299
Range on HMM: 18-272/284.0
GKVAAAKLPANRPLNRYRDVLPYDHSRIILESTQNG---TDYINANLVEFP-----ELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQI
 .. .|.||.|. .|||.|.|||||||..| |....   .|||||..|...        |..|..|||||.| ..||.||||.|.. ..||.. .|....
lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengre

KCFQYWPCGERYAHVnclelDSFQIKYITENRSEEFTVRILELENKK-TKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAGVLSSDVGPAVIHCS
||.||||  . . .      . |..... |.  . .||| |||.|.. |.|.| |.|.||..|||.|||  |  .|.|| ..|..   ... || |.|||
kcaqYwplegevlty.....gdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCs

AGIGRSGTFVMIDSILAEVEATGNLNAVDLGERLLAARQYRVGLIQTPDQLRFTSIAILE
||.||.|||...| .|  .|..| |  ||. | .   |..| | .||..|.||   |.||
aGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealle
0047943 (Phosphotyrosine protein) phosphatases II 47-299 7.5e-82 270.2 In-house 26-270 (273) alignment 
Range on Protein: 47-299
Range on HMM: 26-270/273.0
NAGKVAAAKLPANRPLNRYRDVLPYDHSRIILesTQNGTDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYW
. ..  .|.||.|. .|||.|.|||||||..|  ...|.|||||..|....|....|..|||||.| ..||.||||.|.. ..||....|....||.|||
plltysvallpenkdknrykdilpydhsrvkl..gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYw

PCGERYahvNCLELDSFQIKYITENRSEEFTVRILELENKKTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAGVLSSDVGPAVIHCSAGIGRSG
|  .     . |. . |..... |.  . .||| |||.|..|.|.|.|.|.||..|||.|||  . ..|.|. ..|.|   . . || |.|||||.||.|
plegge...lsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtg

TFVMIDSILAEVEATGnlnAVDLGERLLAARQYRVGLIQTPDQLRFTSIAILE
||...| .|  .|..|    ||. | .   |..| | .|||.|.||   |.||
tfialdllldqlekeg...gvdvleavkllrsqRpgmvqtpeqyrflyealle
0040438 (Phosphotyrosine protein) phosphatases II 50-299 1.3e-81 269.6 In-house 34-274 (317) alignment 
Range on Protein: 50-299
Range on HMM: 34-274/317.0
KVAAAKLPANRPLNRYRDVLPYDHSRIILESTQN--GTDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWP
    |.||.|...|||.|.|||||||..| ....  ..|||||..|..|.|....|..|||||.| ..||.||||.... ..||.. .|....||.||||
tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwp

CgERYAHVnclelDSFQIKYITENRSEEFTVRILELENKKTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAGVlsSDVGPAVIHCSAGIGRSGT
  . . ..     . |..... |   ...|.| ||.|.....|.| |.|.||..|||.|||. |  .|.|| ..|.|    .. || ..|||||.||.||
l.getlty.....gdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale..dpggpvlVHCsaGvgRtGt

FVMIDSILAEVEATGnlnAVDLGERLLAARQYRVGLIQTPDQLRFTSIAILE
|.... .|  .| .|    ||. | .   |..| | .|||.|.||   |.||
fiaaylmleqlekeg...gvdveeavkelreqRpgavqtpeqyrflydalle
0045450 (Phosphotyrosine protein) phosphatases II 48-297 5.4e-78 258.1 In-house 44-300 (307) alignment 
Range on Protein: 48-297
Range on HMM: 44-300/307.0
AGKVAAAKLPANRPLNRYRDVLPYDHSRIILESTQ---NGTDYINANLV--------EFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVME
 |.  .|.||.|...|||.|.|||||.|..| |..   ...|||||. |        ... |....|..|||||.| ..||.|.||.......||.. .|
lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelve

KNQIKCFQYWPCGERYAHVNCleldsFQIKYITENRSEEFTVRILELENK-KTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRN------AGvlss
....||.||||  . .   .      |..... |.  ...||| ||.... .|.|.| |.|.||..|||.|||. .  .|.|. |.|.       |    
lgrekcaqywPdegeeltygn.....ftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkg....

dvGPAVIHCSAGIGRSGTFVMIDSILAEVEATGNLNAVDLGERLLAARQYRVGLIQTPDQLRFTSIAI
  || ..|||||.||.|||.... .|  .|..| |. ||| | .   |. | | .|.|.|.||   |.
..gpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeal
0039614 (Phosphotyrosine protein) phosphatases II 51-299 3.8e-76 251.7 In-house 48-287 (297) alignment 
Range on Protein: 51-299
Range on HMM: 48-287/297.0
VAAAKLPANRPLNRYRDVLPYDHSRIILESTQ---NGTDYINANLVEFPEL-GKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQiKCFQYW
   |.||.|...|||.|.|||||||..| .     ...|||||..|....| ....|..|||||.| ..||.||||.......||.| .|... ||.|||
ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqyw

PCGERyahvnclELDSFQIKYITENRSEEFTVRILELENkkTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAGVLSSDVGPAVIHCSAGIGRSG
|  .        . . |.......   . .||| ||..|  ..|.| |.|..|. |||.|||  . ..|.|| ..|.|   ... || ..|||||.||.|
peegg.......tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtG

TFVMIDSILAEVEATGNLNavdLGERLLAARQYRVGLIQTPDQLRFTSIAILE
||.... .|  .| .|...   . | .   |..| | .|||.|.||   |.||
tfiaaylmleqlekeggvd...vleavkelreqRpgavqtpsqyrflydalle
0043336 (Phosphotyrosine protein) phosphatases II 49-297 1.2e-75 249.9 In-house 35-273 (278) alignment 
Range on Protein: 49-297
Range on HMM: 35-273/278.0
GKVAAAKLPANRPLNRYRDVLPYDHSRIILESTQNG--TDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYW
.    |.||.|...|||.|.|||||||..|.....   .|||||..|.... ....|..|||||.| ..||.||||.... ..||.. .|....||.|||
dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYw

PcgeryahVNCLELDSFQIKYITENRSEEFTVRILELENKKTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAGVlsSDVGPAVIHCSAGIGRSG
|        . |. . |..... |.  . .||| ||..|....|.| |.||||| |||.|||  .  .|.|| . |.|    .. || ..|||||.||.|
p.......ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale..dsngpvlVHCsaGvgRTG

TFVMIDSILAEVEATGnlnAVDLGERLLAARQYRVGLIQTPDQLRFTSIAI
||.... .|  .| .|    ||| | .   |..| | .|||.|.||   |.
tfialyllleqlekeg...gvdleeavkelreqRpgavqtpsqyrflyeal
DSPc_SM00195 48-299 1.4e-74 246.1 In-house 16-260 (263) alignment 
Range on Protein: 48-299
Range on HMM: 16-260/263.0
AgKVAAAKLPANRPLNRYRDVLPYDHSRIILESTQ--NGTDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQY
  ..  |. ..|.  |||...|||||.|..|....  .|.|||||| .....  |.||..|||||.| ..||.||||...| ..||.. .|....|| .|
k.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdry

WPCGEryahVNCLELDSFQIKYITENRSE-EFTVRILELENKKTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAGVLSsdVGPAVIHCSAGIGR
||  .     .  . .....| . ..  . |...| |||......||| |..|.| .||| |||. . ..|..| ....    |   || |.|||||.||
wpees....ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivVhCsaGvgR

SGTFVMIDSILAEVEATGNlnaVDLGERLLAARQYRVGLIQTPDQLRFTSIAILE
.||||.||.|| ..|.. .   ||. | . . |. | |..|| .|..|   ||||
tgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeaile
PTPc_SM00194 48-299 1.4e-74 246.1 In-house 16-260 (263) alignment 
Range on Protein: 48-299
Range on HMM: 16-260/263.0
AgKVAAAKLPANRPLNRYRDVLPYDHSRIILESTQ--NGTDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQY
  ..  |. ..|.  |||...|||||.|..|....  .|.|||||| .....  |.||..|||||.| ..||.||||...| ..||.. .|....|| .|
k.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdry

WPCGEryahVNCLELDSFQIKYITENRSE-EFTVRILELENKKTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAGVLSsdVGPAVIHCSAGIGR
||  .     .  . .....| . ..  . |...| |||......||| |..|.| .||| |||. . ..|..| ....    |   || |.|||||.||
wpees....ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivVhCsaGvgR

SGTFVMIDSILAEVEATGNlnaVDLGERLLAARQYRVGLIQTPDQLRFTSIAILE
.||||.||.|| ..|.. .   ||. | . . |. | |..|| .|..|   ||||
tgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeaile
subfamily_PTPRD_pd Subfamily PTPRD 49-299 1.8e-74 246.4 In-house 38-279 (564) alignment 
Range on Protein: 49-299
Range on HMM: 38-279/564.0
GKVAAAKLPANRPLNRYRDVLPYDHSRIILESTQN--GTDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYW
 .. ||. |||.. ||| ....|||||..|.....  |.|||||. ..  .  | || .||||..| . ||.||||.||. ..||.|. ||.. || .||
ftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYW

PCGEryahvnCLELDSFQIKYITENRSEEFTVRILELENKKTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAGvlSSDVGPAVIHCSAGIGRSG
|  .        . ......   |.. .....| ..|..||..|.| | ..|.  ||| |||. .  .|... ..|..   ..| || |.|||||.||.|
Pekg......tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln..epdagPivVhCSaGVGRTG

TFVMIDSILAEVEAtgnLNAVDLGERLLAARQYRVGLIQTPDQLRFTSIAILE
||. ||..|  ...    . ||. . . | |. |  ..||..|  |   ||||
tfividamlerike...ektvDiyqyvkalrkqRnamVqteeQYiFiheaile
0045098 (Phosphotyrosine protein) phosphatases II 47-298 3e-72 238.6 In-house 21-269 (278) alignment 
Range on Protein: 47-298
Range on HMM: 21-269/278.0
NAGKVAAAKLPANRPLNRYRDVLPYDHSRIIlestqngtDYINANLVEFPelGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYW
. ...  | .. |...|||.|.|||||||..        |||||......  .|..|..|||||.|...||.|.||.......||....|....||.|||
ipseitpalylgnldknRykdilpydhsrVk........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqyw

PCGERYAHvnclelDSFQIKYITENRSEEFTVRILELENK----KTKETRVVYHYHYLTWPDFGVPKAP--GYFLSFLFECRNAGV-----------LSS
| |. . .      . |..... | . ...|.| |...|     .. |.| |.|.|||.|||.|||  |   .||..| ..|.|             | .
peggslty......gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllld

DVGPAVIHCSAGIGRSGTFVMIDSILAEVeatgNlNAVDLGERLLAARQYRVG-LIQTPDQLRFTSIAIL
. || ..|||||.||.||.|... .|  .    . . ||| | .   |..| |  .|...|.||   ..|
sggpvlVHCsaGvgRtGtlvaaylmlell....e.ggvdlleavkelrsqRpglavqnleqyrflyefll
0040439 (Phosphotyrosine protein) phosphatases II 53-297 4.7e-72 237.9 In-house 5-242 (249) alignment 
Range on Protein: 53-297
Range on HMM: 5-242/249.0
AAKLPANRPLNRYRDVLPYDHSRIILESTQN--GTDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWPCgE
 |.||.|...|||.|.|||||||..|.....  ..|||||......  ..|.|..|||||.| ..||.|.||.......||.. .|....||.||||  .
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.g

-RYAHvnclelDSFQIKYITENRSEEFTVRILELENKKTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAGVLSSDVGPAVIHCSAGIGRSGTFV
  . .      . |..... .. ....||| |||.|....|.| |.|..|. |||.|||. .  .|.|. ..|.|    .. || ..|||||.||.|||.
gsley......gdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfi

MIDSILAEVEATGNlnaVDLGERLLAARQYRVGLIQTPDQLRFTSIAI
... .|  .| ...   ||| | .   |..| | .|.|.|.||   |.
aaylmleqlekelg...vdleeavkllrsqRpgavqnpeqyrflyeal
subfamily_PTPN6_pd Subfamily PTPN6 52-297 6.2e-71 233.9 In-house 47-293 (306) alignment 
Range on Protein: 52-297
Range on HMM: 47-293/306.0
AAAKLPANRPLNRYRDVLPYDHSRIIL-ESTQNGTDYINANLVE--FPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWPC
  .. | |.  |||. .||.||.|.|| |.   |.|||||| ..  ...  |.|| .|| |..|   ||.|||..||. ..|. | .|... || .||| 
kegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPd

GERYAHvncleLDSFQIKYITENRSEEFTVRILELE-NKKTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAGVLSS--DVGPAVIHCSAGIGRS
 |.  .       . ... ..|.. .....| | .. .|| ||.| |..||. .||| |||| || .|.|| . ..    ..  . || |.|||||||| 
eeekee.....yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRt

GTFVMIDSILAEVEATGNLNAVDLGERLLAARQYRVGLIQTPDQLRFTSIAI
|||..|| .|  .| .|.   .|. .    .|..| ||.|| .| .|   ||
GtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykai
Y_phosphatase Protein-tyrosine phosphatase 59-298 7.1e-71 233.7 Pfam-A 1-234 (235) alignment 
Range on Protein: 59-298
Range on HMM: 1-234/235.0
NRPLNRYRDVLPYDHSRIILESTQNGTDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWPcgerYAHVNCL
|.  |||.|.||||..|. |..... .|||||| |.  .  |..|..||||..| ..||.|||....|...||....||.. || ||||     .  . |
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp....eeeeesl

ELDSFQIKYI-TEN-RSEEFTVRILELENKKTK-ETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAGvlSSDVGPAVIHCSAGIGRSGTFVMIDSIL
. .......   |.  ..|.|.| |||..||.. |.| |...|| .||| |||. |  .|... ....    ... || |.|||||.||.||||..| .|
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldill

AEVEATGNlnaVDLGERLLAARQYRVGLIQTPDQLRFTSIAIL
 ..||...   ||. . .   |. | |..|. .|. |   |||
eqleaeee...vdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 59-298 7.1e-71 233.7 In-house 1-234 (235) alignment 
Range on Protein: 59-298
Range on HMM: 1-234/235.0
NRPLNRYRDVLPYDHSRIILESTQNGTDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWPcgerYAHVNCL
|.  |||.|.||||..|. |..... .|||||| |.  .  |..|..||||..| ..||.|||....|...||....||.. || ||||     .  . |
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp....eeeeesl

ELDSFQIKYI-TEN-RSEEFTVRILELENKKTK-ETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAGvlSSDVGPAVIHCSAGIGRSGTFVMIDSIL
. .......   |.  ..|.|.| |||..||.. |.| |...|| .||| |||. |  .|... ....    ... || |.|||||.||.||||..| .|
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldill

AEVEATGNlnaVDLGERLLAARQYRVGLIQTPDQLRFTSIAIL
 ..||...   ||. . .   |. | |..|. .|. |   |||
eqleaeee...vdvlqivkelRkqRpgmvqsleqYiflykail
0042113 (Phosphotyrosine protein) phosphatases II 54-298 1.2e-70 233.0 In-house 4-240 (245) alignment 
Range on Protein: 54-298
Range on HMM: 4-240/245.0
AKLPANRPLNRYRDVLPYDHSRIILESTQNG--TDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWPCgER
|.||.|...|||.|.|||||.|..| ....   .|||||..| ...  ...|..|||||.| ..||.|.||.......||.. .|....||.||||  . 
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.ge

YAHVnclelDSFQIKYITENRSEEFTVRILELENKKTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAGVLSSDvGPAVIHCSAGIGRSGTFVMI
.  .     . |......|.  ...|||.||..|....|.| |.||||| |||.|||  . ..|.|| ..|.|   .|. || ..|||||.||.|||...
slty.....gdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsn.gpvlVHCsaGvgRtGtfiaa

DSILAEVEATGnlnAVDLGERLLAARQYRVGLIQTPDQLRFTSIAIL
. .|  .|...    |.| | .   |..| | .|||.|.||   |.|
ylmleqlekel...gvsleeavkelrsqRpgavqtpsqyrflyeall
subfamily_PTPN3_pd Subfamily PTPN3 45-298 3.3e-70 231.2 In-house 26-272 (280) alignment 
Range on Protein: 45-298
Range on HMM: 26-272/280.0
RENAG-KVAAAKLPANRPLNRYRDVLPYDHSRIILESTQNgtDYINANLVEFPELG----KRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQ
| . | .. ||..|.| . |||||.||||. |..|.....  |||||| |..   .    .||| .||||..|| .|||||||..|. ..||  ..|. .
rkkpglaisaarkpenlsknryrdilpydatrvklkeset..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGr

IKCFQYWPCgeryaHVNCLELDSFQIKYITENRSEEFTVRILELENKKTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAGvlSSDVGPAVIHCS
.|| ||||      . . ||. .|..|   |...... .| | |..|.||| | . .  || ||| |||. .  ||.|. . |..   |..  | |.|||
vkChqyWPe.....tedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr..sgkeePvvvhCs

AGIGRSGTFVMIDSILAEVEATGNLNAVDLgerLLAARQYRVGLIQTPDQLRFTSIAIL
|||||.| .....  || .||. ... .|.   .   |. |  |.||..| .|   |||
aGigrtGvlilletalalieaaepvypldi...vrtmrdqramlvqtasqykfvCeail
subfamily_PTPRB_pd Subfamily PTPRB 50-297 3.7e-70 231.3 In-house 42-281 (293) alignment 
Range on Protein: 50-297
Range on HMM: 42-281/293.0
KVAAAKLPANRPLNRYRDVLPYDHSRIILES--TQNGTDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWP
.|.||.|..||  |||...|||||||. |..  ...|.|||||| ..  .  . .| .|||||.| |.||.||||..|....|| ...|| ..|| .|||
avkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWP

CGeryahVNCLELDSFQIKYITENRSEEFTVRILELENkkTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAGVLSSDVGPAVIHCSAGIGRSGT
        .     . ... ..|.. |....| |..|.  .||.| | .||...|||.|||...  .|.|. . |.|   ... .| |.|||||.||.||
ad.....eepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGt

FVMIDSILAEVEAtgnLNAVDLGERLLAARQYRVGLIQTPDQLRFTSIAI
|. .| .| ..|     . ||.   . . |. |. |.|| .|  |   ..
fialdrllqaiee...edyvdifgivaelReeRnllvqtekqYifihqcv
0037934 (Phosphotyrosine protein) phosphatases II 53-293 8.8e-68 223.7 In-house 4-234 (243) alignment 
Range on Protein: 53-293
Range on HMM: 4-234/243.0
AAKLPANRPLNRYRDVLPYDHSRIILestqNGTDYINANLVEFPelgKRYILAQGPLPHTADH----FWQMVWENNSKAVIMLNKVMEKNQIKCFQYWPc
 |.||.|.. |||.|.|||||||..|    .|.|||||||.. .   .|.|. |||||.| ..    ||.|.||.......||.. .|....||.|||| 
iallpenlsknrysdilpydhsrvkl....egsdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.

geryaH-VnclELDSFQIKYITENRSEEFTVRILELENKK-TKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAG-------VLSSDvGPAVIHCS
       |   . . |..... |.  ...||| |.|||.. ...|| |.||||| |||.|||  |  .|.|| |.|.         .|.|. || ..|||
.....gev...tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsg.gpvlVHCs

AGIGRSGTFVMIDSILAEVeatgnlNaVDLGERLLAARQYRVG-LIQTPDQLRFT
||.||.||..... .|  .      . ||| | .   |. | |  .|||.|.|| 
aGvgRtGtliaaylmllll......g.vdleeavkllreqRpgkavqtpsqyrfl
subfamily_PTPN9_pd Subfamily PTPN9 43-300 1e-65 216.7 In-house 26-289 (297) alignment 
Range on Protein: 43-300
Range on HMM: 26-289/297.0
QSRENAGKVAAAKLPANRPLNRYRDVLPYDHSRIILEST--QNGTDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQI
.... .|.. |.||.||   ||| ||| ||..|. |...  .. .|||||| |.  .  | .| .||||..| . ||.||||..   ..|  .|.|. ..
rnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrl

KCFQYWPCGERyahvNCLELDSFQIKYITENRSEEFTVRILELENKKTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAG-VLSSDVG-------
|| |||| .|     .. |  ..... .  . .|...||.||..| ||.|.| | |. .|.|||.|||..   .| .| . |..  ......|       
kcgqyWpleee....ssaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghp

---PAVIHCSAGIGRSGTFVMIDSILAEVEATGNLNAVDLGERLLAARQYrvgLIQTPDQLRFTSIAILEG
   | |.||||||||.|||. .|  |...| .|... |.  ..| . | .    ||||.|  |  .|.|| 
sgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqraf...siqtpeqyefcylavley
subfamily_PTPN12_pd Subfamily PTPN12 47-299 1.4e-64 212.8 In-house 28-275 (290) alignment 
Range on Protein: 47-299
Range on HMM: 28-275/290.0
NAGKVAAAKLPANRPLNRYRDVLPYDHSRIILESTQN--GTDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQ
.. . .|.. . |.  |||.|.||||.||. |. ...  | ||||||... .|  ..|| ||||||.| | ||.|.|| | . |.|. ...| ...|| .
kvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCer

YWPCgeryAHVNCLELDSFQIKYITENRSE-EFTVRILELENKktKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAGVlsSDVGPAVIHCSAGIG
|||      . . || ..|... ..|.. . .|..| |..|..  ||.|.|| .||  ||| |||...   |... . |.     |.  | |.|||||.|
YWpe....egeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..sedaPlvvhCsaGvG

RSGTFVMIDSILAEVEATGNLNAVDLGERLLAARQYRVGLIQTPDQLRFTSIAILE
| || . || .   ..|    . .|. . .|  |. |. |.|| .| ..   |..|
rtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavae
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 46-294 1.8e-63 209.3 In-house 34-272 (288) alignment 
Range on Protein: 46-294
Range on HMM: 34-272/288.0
ENAGKVAAAKLPANRPLNRYRDVLPYDHSRIILES--TQNGTDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCF
|.  .| |..|. | . ||||..||||. |. |.   ...|.|||||. ..  .  |.|| .||||..| ..||..|.||... ..||....|... || 
ektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCe

QYWPCGERYAHvncleLDSFQIKYITENRSEEFTVRILELEnkKTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAGvlSSDVGPAVIHCSAGIG
.||| ...  .       |.... . ..  |.|..| |.||  |.|. . . .|.||.||| |||..   .| .|    .|   ..|.|| ..|||||.|
eYWPdadkpkn.....yGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvan..qadtgpiivhCsaGvG

RSGTFVMIDSILAEVEAtgnLNAVDLGERLLAARQYRVGLIQTPDQLRFTS
|.|||. .| .. .||.    . .|. . .   |. |  |.||  |  |  
rtgtFialdalidavee...edyiDvagtvaklRkqRallvqtlkqYefiy
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 49-299 4.5e-63 208.0 In-house 31-274 (281) alignment 
Range on Protein: 49-299
Range on HMM: 31-274/281.0
GKVAAAKLPANRPLNRYRDVLPYDHSRIIL--ESTQNGTDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYW
    |.| ..|.  |||...  ||..|. .  ..... ||||||| |.  .  |.|| .|||.|.. ..|||||||.. .|..|. . .|....|| .||
ntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYW

PcgERYAhvnCLELDSFQIKYITENRSEEFTVRILELeNKKTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAGVLSSDvGPAVIHCSAGIGRSG
|  .  .    |..  ...| ..|......  | ..| .... ||| | . .|..||| |||. .  .|.|  | ...   ...  | |||||||.||.|
P..ddns...elkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktk.aplvihCsaGvGrtG

TFVMIDSILAEVEAtgNLNAVDLGERLLAARQYRVGLIQTPDQLRFTSIAILE
|.. .| .. .|||  .|. .|. . .   |. |  ..||  | .|   |.|.
tyialDrlvkavea..eleeldvkavvaelrkernlmvqtvvqyefvykavld
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 51-299 6.9e-62 204.3 In-house 38-278 (318) alignment 
Range on Protein: 51-299
Range on HMM: 38-278/318.0
VAAAKLPANRPLNRYRDVLPYDHSRIILEST--QNGTDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWPC
   .  |.|.  ||| ..|.|||.|. |. .  ..|.|||||| ..  .  | || ||.|||.| . ||.|||| ||. ..|| ...|. ..|. .||| 
slkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPs

GeryahvNCLELDSFQIKYITENRSEEFTVRILELENKKTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAGvLSSDVGPAVIHCSAGIGRSGTF
       .  .... ...   | .......| .........|.|.|  ||| .||| |||. .. .|... . ..|  ..|..|| |.|||||.|| |.|
k......gsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaq.qksgagpivvhCsaGvGrtGvf

VMIDSILAEVEATGnlnAVDLGERLLAARQYRVGLIQTPDQLRFTSIAILE
...|..|  ..| .    ||. .     |. |  ..|| ||  |   ..||
iavdillerikaea...lvDvfqtvkqlreqrnlmvqtedqyefiydvlle
subfamily_PTPN13_pd Subfamily PTPN13 52-299 1.5e-61 203.1 In-house 30-267 (273) alignment 
Range on Protein: 52-299
Range on HMM: 30-267/273.0
AAAKLPANRPLNRYRDVLPYDHSRIILESTQNgtdYINANLVEFPEL--GKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWPCG
  .|  .|.  ||||.|||||..|..|..  .   ||||.|.. |      .||..|||||.|.. ||||||| ... ..|. .  ||...|| .|||  
evgkkkenkdknryrnvlPydetrvklgdegg...yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPes

ERYAhvnCLELDSFQIKYITENRSEEFTVRILELENKKTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNagvLSSDVGPAVIHCSAGIGRSGTFV
..         . .... .  .. ..|.|| |........|.| | | .. .||| |||...  .| |. | |.   | .| || |.|||||||||||..
knkk...lkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrr...lqtdagPivvhcsaGiGrsGtli

MIDSILAEVEATGNLNAVDLgerLLAARQYRVGLIQTPDQLRFTSIAILE
 || .|  .|   ...  ..   .   |. | |..|| ||  |   ||||
tidvvlglierdkefdvkei...vrklreqrqgvvqtkdqyifvykaile
subfamily_PTPRG_pd Subfamily PTPRG 47-299 1.5e-60 200.0 In-house 35-285 (563) alignment 
Range on Protein: 47-299
Range on HMM: 35-285/563.0
NAGKVAAAKLPANRPLNRYRDVLPYDHSRIILESTQN--GT-DYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCF
.  .. ... | |.  ||| ....||.||. |... .  .. |||||| ..  . .| .| .||||..|.| ||.|.||.|.. ..|. .. |... ||.
kdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcd

QYWPCgERYAHVNCLELDSFQIKYITENRSEEFTVRILELENKKT-KETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECrnAGVLSSDVGPAVIHCSAGI
.|||  .   ... |..   . . ..   ....... |.|..||  .. ..|..||| .||| |||. . . |.|      .    ...|| |.|||||.
vYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks..saankaeaGPivvHcsaGv

GRSGTFVMIDSILAEVEATgnlNAVDLGERLLAARQYRVGLIQTPDQLRFTSIAILE
||.||....|..| ....    |||.. . |   |  |  |.|| .|  |   |.||
grtGtyivldtllkqiqqe...navnvfgflkhiraqRnflvqteEqYiflhdalle
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 47-299 3.9e-60 198.6 In-house 44-288 (298) alignment 
Range on Protein: 47-299
Range on HMM: 44-288/298.0
NAGKVAAAKLPANRPLNRYRDVLPYDHSRIILES--TQNGTDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQ
.. .  .|. |.|.  ||| |....|.||..||.  ... .|||||  ..  .  . .|..|.||..|   ||.||.|.......||... |....|. .
eeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhk

YWPC--GERYAHVNCleldsfqiKYITENRSEEFTVRILELENKKTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNaGVLSSDVGPAVIHCSAGI
|||    |.| ...         .   ...  ...|| |....||....| | . |. .||| |||.     | .| . |      .   | ...||||.
ywPdegketygeitv........sllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra.sqqqagnkpvivqCsaGv

GRSGTFVMIDSILAEVEATgnlNAVDLGERLLAARQYRVGLIQTPDQLRFTSIAILE
||||||. |||.|  |..    . ||. . . . |. |.|..|| .|  |   |.||
gRsGtfiaidsvlervkke...qvvDvfqvvkvlRkkrpgavqteeqYvfiyeavle
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 55-297 1e-57 190.2 In-house 16-260 (270) alignment 
Range on Protein: 55-297
Range on HMM: 16-260/270.0
KLPANRPLNRYRDVLPYDHSRIILESTQ--NGTDYINANLVE-FPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWPCgER
.   .. ||||.|.||  ..|..||. .  . | ||||| |. | .  |.|| |.|||| |  .||.|.||....|..|. ...||.. || .|||  |.
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpa.ep

YAHVNClELDSFQIKYITENRSEEFTVRILELEnKKTKETRVVyHYHYLTWPDFGVPKAPG------YFLSFLFECRNAGVLSSDVGPAVIHCSAGIGRS
  .|.. |    ..  ..|...| . .. |.|| .| .| |.| |..| |||| |||....        |. | . |.     .. .| ..|||||.||.
kekvkl.edgkikvlalseekeegyiltrlrle.ekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRt

GTFVMIDSILAEVEATGNLNAVDLgerLLAARQYRVGLIQTPDQLRFTSIAI
||....| ..  .| |.... . .   . . |..|. |.|.|.| .|   |.
GtlialDiavrlLeetkkvdvlai...ieelRkdRmalvqhpeqyeflykav
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 50-299 5.4e-57 188.3 In-house 39-281 (319) alignment 
Range on Protein: 50-299
Range on HMM: 39-281/319.0
KVAAAKLPANRPLNRYRDVLPYDHSRIILESTQ--NGTDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWP
..  |. . |.. |||...|.||..|..| . .  .|.|||||. ..  .  ...| .|.|| .| . ||.||||..|  |.||.|. || ..|. .|||
tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywp

CGeryahvNCLELDSFQIKYITENRSEEFTVRILELENKKTK-ETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAgVLSSDVGPAVIHCSAGIGRSG
        |  |   . ..   |.. |.. .| |.|..|... ||| | |..|. ||| .||.     | .| . |.. .  .. || |.|||||.|| |
ee......nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirks.rektqsgPivvhCsaGvGRtG

TFVMIDSILAEVEATgnlNAVDLGERLLAARQYRVGLIQTPDQLRFTSIAILE
||...| .|  |.     ...|. .     |  |  ..|.|.| .|   |.||
tfivldamlervkee...gvlDvfstvsrlRtqRnimvqrpeqYkfiyealle
subfamily_PTPRK_pd Subfamily PTPRK 52-302 8.9e-57 187.3 In-house 36-278 (314) alignment 
Range on Protein: 52-302
Range on HMM: 36-278/314.0
AAAKLPANRPLNRYRDVLPYDHSRIILESTQNG--TDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWPCG
 |||   ||  ||. |.|.||.||..| ....   .|||||.|..  .  . .| .||||..|   ||..|...|. ...||....|. ..|| .|||  
daakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed

ERYaHvnclelDSFQIKYITENRSEEFTVRILELEN--KKTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAGVLssDVGPAVIHCSAGIGRSGT
 .  .      . ......  .  .|. |||. .|.  .. .|.|.| ....|.|||..||.    .|... .  .      . |. |.||||| ||.||
tev.y......gdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee..eaGrivvhCsaGaGrtGt

FVMIDSILAEVEATgnlNAVDLGERLLAARQYRVGLIQTPDQLRFTSIAILEGTL
|..||..|  .|     . ||. .   . |...| ...| .| .|   .|||  |
fiaidivldmiere...gvvdvfnavktlrsrkvnmveteeqykfiydvileacl
subfamily_PTPRA_pd Subfamily PTPRA 50-299 9.9e-57 187.3 In-house 49-293 (330) alignment 
Range on Protein: 50-299
Range on HMM: 49-293/330.0
KVAAAKLPANRPLNRYRDVLPYDHSRIILEST--QNGTDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWP
 . .|.   |.  ||. ..||||.||.||     .. .|||||  ..  .  ...| ||||. .| . ||.|.|| .| ...|| .. |... || ||||
tlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywP

CGERYAHVNCleldsfQIKYITENRSEEFTVRILELE----NKKTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAGVLSSDvgPAVIHCSAGIG
    ... |       ...   |. ....||| . ..    ... |..|.|  .|. .|||.|||  |   |..| . ..    |..  | |.|||||.|
deGlvtyGni......rvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag..pivvhcsaGvG

RSGTFVMIDSILAEVEATGNLNAVDLGERLlaaRQYRVGLIQTPDQLRFTSIAILE
|.|||...|..|. |.| . ..  .  .||   |. |  ..||  |  |   ..||
rtGtfivldavlervkaerkvdvfefvkrl...rlqrpqmvqtdeqyefiykvlle
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 53-298 6.2e-56 184.3 In-house 32-274 (287) alignment 
Range on Protein: 53-298
Range on HMM: 32-274/287.0
AAKLPANRPLNRYRDVLPYDHSRIILES-TQNGTDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWPcgER
||.  |.   ||| ||||.|..|..|   .. |.|||||| |   .  ...| ||||.. |   ||..|.|..| .||.. . .|. . ||..|||  ||
aaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywP..er

yaHVnCLELDSFQIKYI-TENRSEEFTVRILELENKKTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFEC---RNAGVLSSDVGPAVIHCSAGIGRSGT
  .|  . .  . .  .  .... |..|| | | . .|.|.|||  ...|.||| ... .   .. | ...    ..   .|.||| |.|...||||||.
..ev.PmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGi

FVMIDSILAEVEATGNlnaVDLGERLLAARQYRVGLIQTPDQLRFTSIAIL
.. .  ..   | .|.   ||    ..  |.|| .|.|.. |||..  |. 
llatlvlvsrledlGr...vdvaavvirlreyraalvqavvqlrllyealv
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 52-297 7.1e-56 184.3 In-house 21-264 (274) alignment 
Range on Protein: 52-297
Range on HMM: 21-264/274.0
AAAKLPANRPLNRYRDVLPYDHSRIILEST---QNGTDYINANLVEFPEL-GKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWP
.  ... .   |||...|| ..||..|||    .. ..||||| .  ..   | |. .|||||.| . ||.|....... ..|| |. |.|. || .|.|
eeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfP

CGERYAHVNclELDSFQIKYITENRSEEFTVRILELENKKTkeTRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAGVLSSD-VGPAVIHCSAGIGRSG
  | |   .  . . ..||    .. ....|| | |.. .   .| |.|| |  |||  .|. .  .|... | ...   ..  ..|.|.|||||||| |
daedyeise..rygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtG

TFVMIDSILAEVEATgnlNAVDLGERLLAARQYRVGLIQTPDQLRFTSIAI
 |. |.  . .....   . ||. .     |. | |..|| .| ..   |.
cfiaisiavrqlree...ivvdvlkivcnlrldrGGmvqtseqyelihral
subfamily_PTPN14_pd Subfamily PTPN14 45-293 1.3e-55 183.5 In-house 35-288 (300) alignment 
Range on Protein: 45-293
Range on HMM: 35-288/300.0
RENAGKVAAAKLPANRPLNRYRDVLPYDHSRIILESTQ-NGTDYINANLVEFPELGK--RYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIK
... ... .|||| | . ||..|||||...|. | .|. | |.||||  .. .  ||   || |||||..|   |||||||.. . ..|| .  |. . |
kredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkek

CFQYWPCGERyaHVNCLELDSFQIKYITENRSEEFTVRILELENKKTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAGVLSSD-------VGPA
.|.|.|  |   . . .| . |..     . |. .. . |.|.   .|| | |.|  |  ||| |||. .  |||.| | .     ...         | 
sfkyfPkles..kkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPv

VIHCSAGIGRSGTFVMIDSILAEVEATgnlNAVDLGERLLAARQYRVGLIQTPDQLRFT
..|||||.||.|  .. | ..| .|     . .|. . |   |. |  |.||  | .| 
lvhCsaGvGrtGvlilsdlliatlehn...eeidikkvlarLreqrmllvqtlaqYkfv
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 57-297 2.6e-55 182.7 In-house 44-279 (305) alignment 
Range on Protein: 57-297
Range on HMM: 44-279/305.0
PANRPLNRYRDVLPYDHSRIILESTQNG--TDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWPCGERYAh
 ||.  ||.... ..|..||||  ...   .|||||. |.  .  |.||.|||||..| . ||....|   . ..|| |..| .. || ||||  ...  
eankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktek.

vncLELDSFQIKYITENRSEEFTVRILELEN-KKTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAGVLSSDVgPAVIHCSAGIGRSGTFVMIDS
    |...|...   |.  .... | |.. . .. ||.|.| .|.  .||| |||. .. .||.. . ...   . .| | ..|||||.||.|.|...| 
...kefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgv.pllVhCsagvgRtGvfiavdi

ILAEVEATGNlnaVDLGERLLAARQYRVGLIQTPDQLRFTSIAI
 |  ... .    ||. | | ..|. |....|| ||  |   |.
alerlkkEev...vdvfevlkqlRskrmkmvqtldqYvflhdal
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 54-300 1.1e-54 180.3 In-house 4-241 (250) alignment 
Range on Protein: 54-300
Range on HMM: 4-241/250.0
AKLPANRPLNRYRDVLPYDHSRIILESTQ--NGTDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIkCFQYWP--CG
|| |.|.  ||| |....|.||..||...  . .|||||  ..  .  | .| .||||..|  .||.||.|..|....||... |...  . ||||    
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPveka

ERYAHVNcleldsfqIKYITENRSEEFTVRILELENKKTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAGvLSSDVGPAVIHCSAGIGRSGTFV
|.| .|         ..   ..   ..|.| | | ..| .. |.| ..|...||| |||.     | .| . .      .. .| ...||||.||||.|.
ekyGdvt........vsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasq.qqagnaPvivqCsaGvgrsGafi

MIDSILAEVEATgnlNAVDLGERLLAARQYRVGLIQTPDQLRFTSIAILEG
 ||..|  ..     . ||. . . . |. |.. ... .|  |   .||. 
aidavlerlkke...kvvdvfkvikvlrkdrphavesleqyvfvyeiilka
subfamily_PTPN23_pd Subfamily PTPN23 42-299 3.7e-54 178.5 In-house 28-278 (288) alignment 
Range on Protein: 42-299
Range on HMM: 28-278/288.0
WQSRENAGKVAAAKLPANRplNRYRDVLPYDHSRIILESTQNgtDYINANLVE-FPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQI
 .   .   .|.||| ...  ||.||.|||||.|. |.....  |||||  |.        .| .|.||. |.  ||.||.|. |. ..|| .  |... 
qdkearkrsiaiaklysek..nrsrdilPyDhnRvklrgskD..DYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkp

KCFQYWPCGER--YAHVNcleldsFQIKYITENRSEEFTVRILELENKKTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRN--AGVLSSDVGPAVI
|. .|||  .     . .      ...    ....|..  |.|.|| ....... | | .. .||..|||..|. .| || | ..    |      | |.
kvdrYwPedkgetvkfgd......lsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvv

HCSAGIGRSGTFVMIDSILAEVEAT-GNLNAVDLGERLLAARQYrvgLIQTPDQLRFTSIAILE
|||||.||.|.| .. ....|.|.  | |. ... .|| . |..    .|. .||.|.  |.||
hCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrf...mvqekeqlkfsyeavle
subfamily_Ptp69D_pd Subfamily Ptp69D 53-299 3.1e-52 172.6 In-house 42-284 (307) alignment 
Range on Protein: 53-299
Range on HMM: 42-284/307.0
AAKLPANRPLNRYRDVLPYDHSRIILEST--QNGTDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWPCGe
...   |   ||| |. ..|. |..|. .  .. .|||||. ..  .  |..| ||.|.  |.. ||.|..| ... ..|| .. |||. || .|||   
vsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie.

ryahvNCLELDSFQIKYITENRSEEFTVRILELENKK-----TKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAGVLSsdVGPAVIHCSAGIGRS
     .  . ..  .|.. |.. .... | |.. .||      ...| |  |||..|.|. ||...   | .. . |.   |.   .| |.||||| |||
.....devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln..rsPivvhCsaGvgrs

GTFVMIDSILAEVEATGNLNAVdlgERLLAARQYRVGLIQTPDQLRFTSIAILE
|.|| .||.| ...|  ... .   |     |. |  |.|  .|  |   |.|.
gifvaldsllqqlkaedkvdif...etvkdLrsqRnllvqsleqYvflyralld
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 58-299 1.6e-51 169.8 In-house 2-237 (237) alignment 
Range on Protein: 58-299
Range on HMM: 2-237/237.0
ANRPLNRYRDVLPYDHSRIILESTQNGTDYINANLV-EFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWPCGERYAHVN
 |.  ||| ..  |||||..|. . .|.|||||. . .|    |.|| |||||  . | ||||||...   ..||  ..|.|..|| .|||  .. |   
enkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaayg

CLELdsfqiKYITENRSEEFTVRILELENKK-TKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAGVLSSDVGPAVIHCSAGIGRSGTFVMIDSIL
 | .         ..   ..||| | | ..   || |... |.. .||| |||.    .| |  .  |     |. || .||||||.||.| |..||..|
vltv.....slkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidaml

AEVEatgNLNAVDLGERLLAARQYRVGLIQTPDQLRFTSIAILE
 . .   . . ||. . . .  . |  .||| ||  |   .|||
rqak...ekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 53-300 2.6e-51 169.4 In-house 43-278 (315) alignment 
Range on Protein: 53-300
Range on HMM: 43-278/315.0
AAKLPANRPLNRYRDVLPYDHSRIIL--ESTQNGTDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWPCGe
 ||   |.  ||| ....||.||. |    .....||.|||...  .  .||| ||||.. . . ||..|.|..   ..||....|... |. .|||   
vakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.

ryahvnCLELDSFQIKYITENRSEEFTVRILelENKKTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAgvLSSDVGPAVIHCSAGIGRSGTFVM
       .    . .  . |.  .|.||| |       .. | |. .|| .||| ||||    .. .    .      ..||. |.|||||.||.|||. 
......kviyGkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqh..htnsvgaivvhcsaGvGrtGtfit

IDSILAEVEATgnlNAVDLGERLLAARQYRVGLIQTPDQLRFTSIAILEG
.|..| ..||    ||.|. . .   || |....|. .| .|   |.|| 
ldavldqaeae...naidvynfitgvrqnrikmvqvaeqyqfiydallet
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 47-302 2.4e-50 166.7 In-house 49-292 (319) alignment 
Range on Protein: 47-302
Range on HMM: 49-292/319.0
NAGKVAAAKLPANRPLNRYRDVLPYDHSRIILESTQ--NGTDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNkvmeknQIKCFQ
|  . . | |. |.  ||. ..|..|.... || ..  ...|||||  |.     ..|| |||||. | . ||.|.|| |. ....|       . || |
nladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsq

YWPCGEryahVncLELDSFQIKYITENRSEEFTVRILELEN-KKTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAGVLSSDVGPAVIHCSAGIG
|||       |   . . |..|  . . ..|..|| .|| .  | |. | .  .|.| ||| |||. |  .. ..   |       .  . |.|||||.|
ywplki....v..ikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvG

RSGTFVMIDSILAEVEATgnlNAVDLGERLLAARQYRVGLIQTPDQLRFTSIAILEGTL
|.|.....| .|  ..     . ||. . .   || |  |.|   |  |  .|.||  |
rtGvyivldvlldrmkee...kqvdvynfvrdlrqqrntlvqdlvqykfiysalleehl
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 47-302 8.5e-50 164.8 In-house 13-256 (284) alignment 
Range on Protein: 47-302
Range on HMM: 13-256/284.0
NAGKVAAAKLPANRPLNRYRDVLPYDHSRIILEST--QNGTDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNkvmeknQIKCFQ
|. . . | |. |.  ||. ..|..|.... || .  ....|||||  ..     ..|| .||||. | . ||.|.|| |. ....|       . || |
ngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsq

YWPCGEryahVncLELDSFQIKYITENRSEEFTVRILELEN-KKTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAGVLSSDVGPAVIHCSAGIG
|||       |   . . |..|  . . |||..|| .|| .  | |. | .  .|.| ||| |||. |  .. ..   |       .  . |.|||||.|
ywplki....v..ikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvg

RSGTFVMIDSILAEVEATgnlNAVDLGERLLAARQYRVGLIQTPDQLRFTSIAILEGTL
|.|.....| .|  ..     . ||. . .   || |  |.|   |  |  .|.||  |
rtgvyivldvlldrmkee...kqvdvynfvrdlrqqrntlvqdlvqykfiysalleehl
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 55-301 4.6e-49 162.1 In-house 47-284 (297) alignment 
Range on Protein: 55-301
Range on HMM: 47-284/297.0
KLPANRPLNRYRDVLPYDHSRIILESTQNG--TDYINANLVEFPELgkRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQiKCFQYWPCGERY
.   | . .||...|||| ||..|.....    ||.||  |.  .   |.|  | | . | . ||.||.... ....|||.  |... || .||.     
ekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvt

AhvncleLDSFQIKYITENRSEEFTVRILELENKKTKETRVVYHYHYLTWPDFGVPK--APGYFLSFLFECRNAGVLSSDVgPAVIHCSAGIGRSGTFVM
.      . .  ..  . .. | |  | ||... |.| .|||  |... |||  |..     ..| .. | |.     ..  | ..||.||.|| | .. 
t......fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg.PllvhclaGvGrtgvllt

IDSILAEVEATgnlNAVDLGERLLAARQYRVGLIQTPDQLRFTSIAILEGT
|||..||.. .   ..||. . .   || |. |.|| .| .|   |.||  
idsvvaeakre...kevdifglvkklrqerpylvqtkeqykfvyvavleal
0041856 (Phosphotyrosine protein) phosphatases II 59-300 5.7e-49 161.5 In-house 1-170 (182) alignment 
Range on Protein: 59-300
Range on HMM: 1-170/182.0
NRPLNRYRDVLPYDHSRiilestqnGTDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNkvmeknqikCFQYWPcgeryahvncl
|...|||.|.|||||||        . |||||||. ..  ..|.|..||||..|  .|..|..|.. .....|.         ...|||           
nldknrysdilpydhsr........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp...........

eldsfqikyitenrseeftvrilelenkkTKETRVVYHYHYLTWPDFGVPKaPGYFLSFLFECRNagvlssDVGPAVIHCSAGIGRSGTFVMIDSILAEv
                             ....| ...|.|| |||.|||  .  .|.|. |...      . || ..|||||.||.||.|... ..   
.............................ellerlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgtlvaaylmkkl.

eatgnlnAVDLGERLLAARQYRVGLIQTPDQLRFTSIAILEG
        |.| | .   |..| | ..||.|..|   |.|| 
.......gvsleeavklvrsrRpgmvitpnqyfflqlallel
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 51-300 1.1e-48 160.8 In-house 36-276 (315) alignment 
Range on Protein: 51-300
Range on HMM: 36-276/315.0
VAAAKLPANRPLNRYRDVLPYDHSRIILESTQN--GTDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWPc
  .|. . | . |||...||.|..|..||  ..    |||||  ..  .  | || .||||. . | ||.||....  ...|..|  | ..||| |||| 
qrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywP.

gERYAhvNCLELDSFQIKYITENRSEEFTVRILelENKKTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAgvLSSDVGPAVIHCSAGIGRSGTF
 .| |  .  |. |.... .  .   . ..| |    .|..|.| |  ...  ||| ||.|  . .| .. | .      ..  . ..|||||.||.| .
.drka..dsvefGsikvellsleadtdgvarkl..vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad..ngkkefsllvhcsaGvGrtGvv

VMIDSILAEVEATgnlNAVDLGERLLAARQYRVGLIQTPDQLRFTSIAILEG
. ||...|... |   ..||. . .   |. |. |.|| ..  |   |.|| 
isidevvaqikrt...rsvdvfnfvknlrakrpylvqteeeyafiydavled
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 43-298 1.8e-48 159.9 In-house 30-280 (290) alignment 
Range on Protein: 43-298
Range on HMM: 30-280/290.0
QSRENAGKVAAAKLPANRPLNRYRDVLPYDHSRIILESTQNGTD----YINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKN
.| |.  .|  .  . |..|||......||  ||.|   ..  |    ||||  ..  .  |.||..|||...|. .||...|.... ...|| ...|..
dsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieeg

QIKCFQYWPCGeryaHVNCleLDSFQIKYITENRSEEFTVRILELENKKT-KETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAGVLSSdVGPAVIH
. || ||||       ..   .. |.|| . |.  .|.. | ||..||.. .... | .|.  .|.. |  ..|   |. . |  .    .   .. |.|
kvkCqqYWpds....dtka..ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrg.ntsivvH

CSAGIGRSGTFVMIDSILAEVEATGNlnaVDLGERLLAARQYRVGLIQTPDQLRFTSIAIL
||...|||..|. ..  .  .. .|    .|. . |   |. . |..|| .|...    .|
CSdtvgrsavfcaaattinkcktegv...idvfqvlksqRiqkpgsvqtvqqyqgifqivl
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 49-298 2e-48 159.9 In-house 37-275 (287) alignment 
Range on Protein: 49-298
Range on HMM: 37-275/287.0
GKVAAAKLPANRPLNRYRDVLPYDHSRIILESTQNgtDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWPC
 .|  .  . |...||....|..|  |..|. ...  |||||  ..  .  |..|.|..|. .||  ||......| .|..|| . .|... .|.|||| 
devthniasqnkdknRltqilvpdnyrvllkgehp..dyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpe

GEryahvnCLELDSFQIKYITENRSEEFTVRILELENKK-TKETRVVYHYHYLTWPDFG-VPKAPGYFLSFlfECRNAGVLSSDVGPAVIHCSAGIGRSG
..      .. |  ..|. . |........| ||..||. ..... |  |.. .|.. | |..    .| .  | ..     .  .. |.|||...|||.
ek......svvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvi..eemyktqrkrgntsivvhCsdtvGrsa

TFVMIDSILAEVEATGNLNAVDLgerLLAARQYRVGLIQTPDQLRFTSIAIL
.|. ..  . ...  | .. ...   |   |. . | .|| .| .|   ..|
mfcaaattinkckteGviDvfqv...lksqriqkpgsvqtveqykfindivl
subfamily_PTPRN_pd Subfamily PTPRN 50-300 1e-47 157.3 In-house 47-291 (297) alignment 
Range on Protein: 50-300
Range on HMM: 47-291/297.0
KVAAAKLPANRPLNRYRDVLPYDHSRIILES--TQNGTDYINANLV-EFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYW
  ..|| . |   ||...||||||||. |..  ... .|||||  . .       || .||||..|  .|||||||. .  ...| .. |..  .| .||
tkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckryw

PC-GERYAHVncleldsFQIKYITEN-RSEEFTVRILELENKKTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNagVLSSDVGPAVIHCSAGIGR
|  |.   |.       .... ..|   .... || . | | .|.||| |  .|.|.||. ||| ..  .| |               | |.|||.| ||
pdeGsevyhi.......yevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnk..syrGrscpivvhcsdGaGr

SGTFVMIDSILAEVEAtGnLNAVDLGERLLAARQYRVGLIQTPDQLRFTSIAILEG
.|....|| .|. .   | .. .|.   |   |. | ||..| ||..|.  |. | 
tGvyilidlvlnrllk.G.vkeidiaatlehlrdqrpglvktkdqfefaltavaee
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 57-300 8.1e-47 154.5 In-house 41-275 (515) alignment 
Range on Protein: 57-300
Range on HMM: 41-275/515.0
PANRPLNRYRDVLPYDHSRIILESTQN--GTDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWPcgerYAH
  | . |||...|||| .|..||  ..    ||.||  ..  .  | || .|||.. . | ||..|...|  ...|..|  | ..||| .|||       
einfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWP....dkp

VNCLELDSFQIKYITENRSEEFTVRILELenKKTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAGVLSSdvGPAVIHCSAGIGRSGTFVMIDSI
 . ... |.... .. .   . . | |..   | ...| |  .|.  ||| ||||    .| .. | .      .   | .||||||.|| | .. |||.
gdsvkfGsikvelvsleactggikrkltv..lkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt..hpliihcsaGvGrtGvvisidsv

LAEVEATgnlNAVDLGERLLAARQYRVGLIQTPDQLRFTSIAILEG
.|... |   ..||. . .   || |. |.|| .|  |   |.|| 
vahaktt...rmvdvfnfvtnirqkrpylvqtqeqyafiygavled
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 51-299 1e-45 151.3 In-house 40-286 (325) alignment 
Range on Protein: 51-299
Range on HMM: 40-286/325.0
VAAAKLPANRPLNRYRDVLPYDHSRIILESTQN--GTDYINANLVEFPELGKRYILAQGPLPHTADHFWQMV--WEnnSKAVIMLNkVMEKNQIKCFQYW
  .| .|.|.  ||...|...|.||..||. ..   .|||||. ..     . .. || ||..| . .|..|  |.  .  |..|| ...... .| .||
kkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr..csvvvvln.eldlgkdrcavyw

PCGeryaHVNCLELDSFQIKYITENRSEEFTVRILELENKKTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNA--GVL--SSDVGPAVIHCSAGI
|        .  .. ....| .| .   ..  |.|.. . |  ||| |  ... .|.|.||.| |  ..|.|    .    |   .   .| ..|||||.
pke....mgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGv

GRSGTFVMIDSILAEVEATgnlNAVDLGERLLAARQYRVGLIQTPDQLRFTSIAILE
||.|.|. . |.||.|        ||. . .   |. |  ...| ||  .   |. |
GrtGvfislysalakviee...srvdifgfvkklrkdrpsmvetvdqyiliyealve
0036282 (Phosphotyrosine protein) phosphatases II 84-292 1.7e-42 140.4 In-house 1-161 (174) alignment 
Range on Protein: 84-292
Range on HMM: 1-161/174.0
GTDYINANLVEFPELGKRYILAQGPLPhtadhFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWPCgeryahvncleldsfqikyitenrseeftvrilel
|.|||||. . . .  .|.|. ||||.     ||.|..|.....|.||.. .|..  ||..|||                                    
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...................................

enKKTKETRVVYHYHYLTWPDFGVPKAPGyFLSFLFECRNAGVLsSDVGPAVIHCSAGIGRSGTFVMIDSILAEVEatgnLNAVDLGERLLAARQYRVGL
  ... ..| ...|.|| |||.|||  .  .|.|. ....|    .. || ..|||||.||.||.|... .|   .     ..||  . . ..|..| | 
..lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll....eslvdaldlvrelRlqrpgm

IQTPDQLRF
.|||.|.||
vqtpsQyrf
0051429 (Phosphotyrosine protein) phosphatases II 84-301 4.7e-42 139.8 In-house 3-225 (272) alignment 
Range on Protein: 84-301
Range on HMM: 3-225/272.0
GTDYINANLVEFPelG-----KRYILAQGPLPHTADHFWQMvWENNSKAVIMLNKVMEKNQIKCFQYWpCGERYAHVNCLELDSFQIK-------YITEN
 ..||||. |  .  |     .|.....||||.||..||.. .|.. |....| ...|... ||..||  | || |...|. . ..|        .. | 
lsgyiNardvggy..grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdryw.pgirylhlpilddsaptilygalrvtllsee

RSEEFTVRILELENK-KTKETRVVYHYHYLTWPDFGVPKAPgyFLSFLFECRNagvlssdVGPAVIHCSAGIGRSGTFVMIDSILAEVEATGNLN-----
  . ...| |.|... ...|.| |.|.||. |||.|||. .  .|..| ....        || ..|||||..|.||.|... .|. |...  ..     
llldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYllt

AVDLGERLLAARQYRVGLIQTPDQLRFTSIAILEGT
 . | | .   |..| | .||..|..|   |.||  
nlyleeaveelraqrpgavqteeqylflyeallell
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 57-302 1.3e-41 137.4 In-house 31-267 (283) alignment 
Range on Protein: 57-302
Range on HMM: 31-267/283.0
PANRPLNRYRDVLPYDHSRIILESTQNgtDYINANLVE---FPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWPcgerya
  |.. ||.....|.|  |. |.|  .  |||||  .      . .|.|| ||.|| .|   ||.||....  |..|| |..| ..||| ||||      
denkrknrnqeivpadqwrvelksesr..dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWP......

HVNCLELDSFQIKYITENRSEEFTVRILELENK-KTKETRVVYHYHYLTWPDFGvPKAPGYFLSfLFECRNAGVLSSDVGPAVIHCSAGIGRSGTFVMId
.    .   | .    |  |. |... | | ..  .|.| .. || .  | ..| ..|.   |   |.   .    |  || |.|||.||||...|. . 
krGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleyg.eqaiinslv.kfnkvislqteskkgPivvhCstgiGrtavfiaa.

siLAEVEATGNLNAVDLGERLLAARQYRVGLIQTPDQLRFTSIAILEGTL
   | |.       ||. . .   |. |....|| || ..   ..|| .|
..sasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqal
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 47-293 7e-41 135.2 In-house 29-269 (307) alignment 
Range on Protein: 47-293
Range on HMM: 29-269/307.0
NAGKVAAAKLPANRPLNRYRDVLPYDHSRIILESTQNGTDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYW
.   |..  . ||   |||.||   |..||...     .||| || .      |..| |||||  |  .|| |. ... ..|||| ||.|  .||| |||
tpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqyw

PCGERYAHVNCLELDSFQIKYITEN--RSEEFTVRILELENKKTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLfECrnagvLSSDVGPAVIHCSAGIGR
|  |    | . . ..  .. .  .    .|  . . .|. . ....| . |. .  ||| |||.     . .| |         |  | |.|||||.||
pleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainll.ea.....vrydtnpvvvhcsaGvGr

SGTFVMIDSILAEVEATgnLNAVDLGERLLAARQYRVGLIQTPDQLRFT
||| | |  .   . |    |  |. . .   |. |   |||  |  . 
sGtivaislvqdkmiaG..inckdmkklveelrsqrhyaiqteaqylyl
0043147 (Phosphotyrosine protein) phosphatases II 83-293 1.7e-40 133.9 In-house 3-153 (172) alignment 
Range on Protein: 83-293
Range on HMM: 3-153/172.0
NGTDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVmeknqikcfqywpcgeryahvncleldsfqikyitenrseeftvrile
.|.|||||......   .|.|  ||||..| ..||.|..|.. .....|..                                                 
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel................................................

lENKKTKETRVVYHYHYLTWPDFGVPkAPGYFLSFLFECRNAGVLSSDvGPAVIHCSAGIGRSGTFVMIDSILaeveatgnlNAVDLGERLLAARQYRVG
 .. .....| ...|.|| |||.|||  . ..|.||  .... .||.. || ..|||||.||.||.|... .|           ..| | .   |. | |
.lydpellerlgiqylylpwpDhgvp.llellleflefidellalspg.gpvlVHCsaGvgRtgtlvaaylml.........lglsleeavalvrekRpg

LIQTPDQLRFT
 .|.|.|.|| 
avqnpsqyrfl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 53-299 2.2e-40 133.3 In-house 1-238 (239) alignment 
Range on Protein: 53-299
Range on HMM: 1-238/239.0
AAKLPANRPLNRYRDVLPYDHSRIILESTQN--GTDYINAN-LVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWPCG
|||   |.  ||| ... |||||..||   |   .|||||. | ..    | || .|| .  ..  ||.|.|..    ..||  ..|  . ||.||||  
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

E-RYAHvncLeldsfQIKYITENRSEEFTVRILELENKKTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAGVlsSDVGPAVIHCSAGIGRSGTF
  .|.    |     ..     .   .. .| . . .    | | ||.||.  ||| |||.     | .  .  .  .      | |||||||.||.|.|
tskycn...l.....rvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdsl..pgarpwvihcsagvgrtgaf

VMIDSILAEVEatgNLNAVDLGERLLAARQYRVGLIQTPDQLRFTSIAILE
..||..| . .   . ..||. . . | |. |  ..|| .|  |  .|.||
lvidamlrqak...kqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 53-299 2.3e-40 133.3 In-house 2-239 (239) alignment 
Range on Protein: 53-299
Range on HMM: 2-239/239.0
AAKLPANRPLNRYRDVLPYDHSRIILESTQN--GTDYINAN-LVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWPCG
|||   |.  ||| ... |||||..||   |   .|||||. | ..    | || .|| .  ..  ||.|.|..    ..||  ..|  . ||.||||  
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

E-RYAHvncLeldsfQIKYITENRSEEFTVRILELENKKTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAGVlsSDVGPAVIHCSAGIGRSGTF
  .|.    |     ..     .   .. .| . . .    | | ||.||.  ||| |||.     | .  .  .  .      | |||||||.||.|.|
tskycn...l.....rvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdsl..pgarpwvihcsagvgrtgaf

VMIDSILAEVEatgNLNAVDLGERLLAARQYRVGLIQTPDQLRFTSIAILE
..||..| . .   . ..||. . . | |. |  ..|| .|  |  .|.||
lvidamlrqak...kqktvdifnyvkairedrphmvqtseqyvfihlavle
0046846 (Phosphotyrosine protein) phosphatases II 80-293 6.2e-40 132.1 In-house 7-165 (176) alignment 
Range on Protein: 80-293
Range on HMM: 7-165/176.0
STQNGTDYINANLVEFPelgkRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWPCGERYAHvncleldsfqikyitenrseeftvr
  ... |||||||.  .    |.|  |||||.|  .|..|..|.. .||..|.. .|....||..|||  |.. .                         
gldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.........................

ilelenkktketrvvyHYHYLTWPDFGVPKApGYFLSFLFECRNagVLSSDvGPAVIHCSAGIGRSGTFVMIDSILAEveatgnlNAVDLGERLLAARQY
                .|..| |||.|||    ..|..| ..|.  .|... || ..||||||||.||.|... .  |       . ... | |   |..
................qylhlpwpDhgvpdl.elllellefire..alkeg.gpvlVHCsaGigRtgtlvaayllele.......kglsveealalvreq

RV-GLIQTPDQLRFT
|  | .|||.|.|| 
RplgavqtpeQyrfl
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 54-260 3.5e-39 129.2 In-house 32-229 (281) alignment 
Range on Protein: 54-260
Range on HMM: 32-229/281.0
AKLPANRPLNRYRDVLPYDHSRIILES---TQNGTDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWPcge
 . | |   ||| ..   | ||. |.     .| |||| || .  | | . |||.|||   |   ||.|.|..|. |..|| ...| |. || .|.|   
fnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfp...

RYAHVnCLELDSFQIKYITENRSEEFTVRILELenKKTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAgvlssdVGPAVIHCSAGIGRSGTFVM
| ||. ||..| . ..|      . .    |.|      |||.. |. .  |||. ||..   .|  | . |          | |||||||.|||||.. 
rnahc.clqfdklsvsyedstvnkslvttrlnl..syegetrlithwlwkewpdwqvpessevmlkilrkirar......stppvihcsagvgrsgtlma

IDSILAEVEA
..  |  . .
veialqsihs
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 62-289 5.6e-39 128.5 In-house 59-271 (290) alignment 
Range on Protein: 62-289
Range on HMM: 59-271/290.0
LNRYRDVLPYDHSRIILESTQNGtDYINANLVEfpELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWPCGEryahVNCLELD
 |||.||   | .|.||.  ..| ||. || |.   |   .||.||.|  |.  .|.|| ...  |..|| ...|. . || ||.|  |     . | . 
knrykdvvcndktrvilkdGydG.dyvhanyvk..GlkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypeke....GevltfG

SFQIKYITENR-SEEFTVRILELENKKTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAgvlssdVGPAVIHCSAGIGRSGTFVMIDSILAEVEA
.. .    |.   ..   ..| . .|..    ...|..  .|||  |...   .|  |.  |.|       || |.||||||||.|||| |.  |  .  
eitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka......sGpvvvhcsaGiGrtGtfvaievglqilld

TgnlNAVDLGERLLAARQYRVGLIQTPDQ
     ..|| .   | |. |.. .|   |
G...keldlldlvralrnsrlnsvqvdiq
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 52-302 8.2e-39 128.1 In-house 38-237 (392) alignment 
Range on Protein: 52-302
Range on HMM: 38-237/392.0
AAAKLPANRPLNRYRDVLPYDHSRIILESTQ--NGTDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNqikcfqywpcg
..|. . | . |||...|||| .|..||  .  . .||.||  ..  .  | || .||| . . | ||.||...|  ...|..|. | .           
tvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...........

eryahvncleldsfqikyitenrseeftvrilelenkKTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAgvLSSDVGPAVIHCSAGIGRSGTFV
                                     | ...| |  .|.  ||| .|||    .| |. | .      .   | .||||||.||.|  .
.....................................kgddartvaqfhftewPdkdvpkhtssllkfikevkad..fGqythpliihcsagvgrtgvvi

MIDSILAEVEATgnlNAVDLGERLLAARQYRVGLIQTPDQLRFTSIAILEGTL
 |||..|  . |     ||. . .   |. |  ..|| .|  |   |.||  |
sidsvvahakkt...rmvdvfnfvtnirrkrpymvqtkeqyafiygavledll
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 50-298 2.6e-38 126.5 In-house 39-284 (305) alignment 
Range on Protein: 50-298
Range on HMM: 39-284/305.0
KVAAAKLPANRPLNRYRDVLPYDHSRIILESTqNGTDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWPCG
|. | |   ..  |||.||   |. |. ||..    .|| || |  |   ||.| .| || .|   || | .... .|..|| ...||   ||..|... 
kmkafkeaqeagknrykdvgcldnnrvklegp.wpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfask

ERYAHV-------NCLELDSFQIKYITENRSEEFTVRILELENKKTkETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAgvlssdVGPAVIHCSAGI
..             . ..| .   .... . . |  .| .|   . ..| | |||.  ||| ||| |    | .| ..| .       || |.||||||
dkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpge.karkvthyhwidwpdrgvpaadlailellekarps......kgpivvhcsagi

GRSGTFVMIDSILAEVEATgnlNAVDLGERLL-AARQYRVGLIQTPDQLRFTSIAIL
||.|. ||.. || .. |    . .. ....|   |. |   ||| .|  |    ||
grtgsvvmleyildqllag...qiiedtdkilqkireqrnnsiqtdaqylfvhqvil
subfamily_CG7180_pd Subfamily CG7180 46-293 4.9e-38 125.5 In-house 29-282 (296) alignment 
Range on Protein: 46-293
Range on HMM: 29-282/296.0
ENAGKVAAAKLPANRPLNRYRDVLPYDHSRIILESTQ--NGTDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQiKCF
 . |. |..    ||  ||. .|.|||. |..||. .  . .|||||  |.     | ||  ..|  .| | ||..|......||..| |... .. .. 
leigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.myp

QYWPCG--ERYAHVNcleLDSFQIKYITENRSEEFTVR-----ILELENKKTKETRVVYHYHYLTWPD-FGVPKAPGYFLSFLFECRNAGVLS---SDVG
.|||    |.| ..    ..  . |  .. .. .| .      . | |.. . |||.| .... .|.    ||     .. ..   |          . |
sywpnkskeqygeif...veiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeeg

PAVIHCSAGIGRSGTFVMIDSILAEVEATGNLnavDLGERLLAARQYRVGLIQTPDQLRFT
| |...| | .||| .. ||  |  || ....   |. | .   |. | .|... .. .. 
PvvvvssdGasRsGvylaidanlelvekeeev...dvFeavktlrrsRpqLvenveeYkyi
0049772 (Phosphotyrosine protein) phosphatases II 52-293 1.2e-37 125.7 In-house 39-272 (314) alignment 
Range on Protein: 52-293
Range on HMM: 39-272/314.0
AAAKLPANRPLNRYRDVLPYDhSRIIL-ESTQNGTDYINANLVEFPelgKRYILAQGPLPHTADHF----------WQMV--WENNSKAVIM--------
 .|.|..||  ||| |.||.| .| ||     .|.|||||. |  .   ...| .||||..| . |          |.||  ...|.  . |        
lvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlad

-------------LNKVMEKNqikcfqywpcgeryahvncleldsfqiK----------YitenrseeftvrilELENKKTKETRVVYHYHYLTWPDFGV
             |.......                                                     |  . . . .| ...|... .||...
elsrLdaAlgKtpllildgng...........................neptaadlellk..............eelydpelferlgikylripvpDgsa

PkAPGYFLSFLFECRNAgvlsSDVGPAVIHCSAGIGRSGTFVMIDSILAEVeatgNlnaVDLGERLLAARQYRV-----GLIQTPDQLRFT
|  . .|..||  ...|    .. || ..||.||.||.|||| .. ..       .   |.| | |   |. |      |.|....|. | 
p.lledfdeflefieea....dkggpvlvHCkaGkgRtgtfvvaaylmkll....g...vsleealedvrlkRpinpnpgfieqleqyefi
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 59-299 1.2e-37 124.4 In-house 48-277 (439) alignment 
Range on Protein: 59-299
Range on HMM: 48-277/439.0
NRPLNRYRDVLPYDHSRIILEST--QNGTDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQikcfqYWPCGERYAHVN
... |||.|| ..||.|..|. .     . ||||| ..     | || .|||  .|.|.||..|.|...  ..|| ...|  .     |||. .   . .
dqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygd

CleldsfQIKYITENRSEEFTVRILELENK--KTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECrNAGVLSSDVGPAVIHCSAGIGRSGTFVMIDSI
        ..   .    ....| . . |.  .|.  | | ..||..|||  ||    . | ||    |.   . ..|| |.|||||.||.|| . .|  
i......avrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrai.nsandkeeygpvvvhcsagvGrtGtiialdia

LAEVEATgnlNAVDLGERLLAARQYRVGLIQTPDQLRFTSIAILE
| .. .    | ||.   .   |. |  ..|.  |  |   |.||
leqlkle...nkvdikgivkvlrkqrkqmvqalcqyvfiynavle
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 48-209 1.9e-37 123.8 In-house 22-181 (297) alignment 
Range on Protein: 48-209
Range on HMM: 22-181/297.0
AGKVAAAKLPANRPLNRYRDVLPYDHSRIILESTQNGTDYINANLVEFPELG--KRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQY
... ..|| ..    |||||.| .| .|. |  .  ..|||||. | ||.     .||||||||  | | ||..|.|.. ....|. |. |  . ||. |
gesfssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapy

WPCGERyahvNCLELDSFQIKYITENRSEEFTVRILELENKKTKETRVVYHYHYLTWPDFGVPK
||  .     . |.  .. ......   |  .| . ||.    .|.||| |  .|.||| ||| 
wpsvvq....erlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvps
0049260 (Phosphotyrosine protein) phosphatases II 99-292 6.9e-37 121.8 In-house 8-141 (152) alignment 
Range on Protein: 99-292
Range on HMM: 8-141/152.0
GKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWpcgeryahvncleldsfqikyitenrseeftvrilelenkktketrvvyHYH
....| .|||.|.|...||.|..|.. ....||.. .|.. .|| ||.                                                 .|.
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.................................................qyl

YLTWPDFGVPKAPGYFLSFLFECRNAgvLSSDVGPAVIHCSAGIGRSGTFVMIDSILaeveatgnlNAVDLGERLLAARQYRVGLIQTPDQLRF
.| |||.|||. . ..| .|  .. .  . .. || ..|||||.||.||.|... .|         . |.| | .   |. | | ...|.||||
hlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml.........lgvsleeavalvrekRpgavpnpgqlrf
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 60-293 4.2e-36 119.1 In-house 56-281 (305) alignment 
Range on Protein: 60-293
Range on HMM: 56-281/305.0
RPLNRYRDVLPYDHSRIILESTQnGTDYINANLVEFPEL-GKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWPC--GERYAHVN
   |||.||   |.| . |.  .  .||| || |  | .  ||.| ||||| .| |.|| || .|. . ..|| | .|  ..|| ||||   ||.    .
itknryqdvpcqdqsavkldkps.psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelks

CLELDSFQIKYiTENRSEEFTVRILELENKkTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAGVlssdvgPAVIHCSAGIGRSGTFVMIDSILA
 . ..         .|  |  . .|.|     ...  | | ..  ||| ||| .    | .|   | . |      | |.||||||||.|| | |. || 
givvenvsgsk.pmerdaeiqitllnltys.gdqkmsvrhlqwtewpdrgvppckltslellsairgskv......pivvhcsagigrtgtivaieyile

EVeaTGNLNAVDLGERLLAARQYRVGLIQTPDQLRFT
..  . | ..  . | . | |. |   ||.  |  | 
ki..aenkpcppmpelvkalrdqrafsiqndvqylfi
subfamily_ptpA1_pd Subfamily ptpA1 59-251 2e-34 114.1 In-house 47-249 (418) alignment 
Range on Protein: 59-251
Range on HMM: 47-249/418.0
NRPLNRYRDVLPYDHSRIILESTQ--NGTDYINANLVEFpELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWP---CGERYA
|   ||| ..|| .|.|. |.  |  .|.|||||| ..     |..| .||||| |   ||.|||||  . ..||..  |. .||| .|||    ||...
ntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfs

H-VNCLEL-DSFQIKY--ITENRSEEFTVRILELenKKTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFEC---RNAGVLSSDV-GPAVIHCSAGIGRS
   |  |.  .. ..   . ..   |   | . |      ||| . .|.|  |||. .|     |  .|.     .|  . |||   | ..|||||.||.
iygngnevfgtysvelveviqdpereiitrnirl..tfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrt

GTFVMI
|||.  
gtfcta
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 58-290 3e-33 110.0 In-house 32-248 (267) alignment 
Range on Protein: 58-290
Range on HMM: 32-248/267.0
ANRPLNRYRDVLPYDHSRIILESTQNGtdYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNqIKcfQYWPCGERYAHvnc
 |.  ||. |.||||..|.||  ...   ||||  ||  . .. .|. |.||  |  .|.... ...   ...| || . | |.  ..||     |.   
knqernrlddnlpyddtrvilrtkeee..yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdn.ir..lfwPPkmgqak...

lELDSFQIKYITENRSEEFTVRILELENKKTKeTRVVYHYHYLTWPdFGVPKAPgyFLSFLFECRNAGVLSSDVGPAVIHCSAGIGRSGTFVMIDSILAE
 . . . ...  |.  ... .  |||. |.   .. |  |.|  |    . . |  .|  ||       |     | |..||.|.||||||..||| |  
.kyqdltvehslekeendyqiitlelkfknes.ahnvtlyyykkwn.intnnkp..ylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqler

VEATGNLNAVDLgerLLAARQYRVGLIQTPDQL
.   | ..  |.   |. .|. |.||..| .. 
aktegvsdifdf...lrkirsqriglvdtkery
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 63-294 9.8e-33 108.2 In-house 54-274 (301) alignment 
Range on Protein: 63-294
Range on HMM: 54-274/301.0
NRYRDVlPYDHSRiILESTQNGTD-YINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWPCGERyahvNCLELD
.||  | | . |   .|  ..|.   | || .. .   .|.| .||||. |.. || |.   . . ..|| . .||.. || .| |   .    . |...
hryptv.PckPst.avevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkis....ekldig

SFQIKYITENR--SEEFTVRILELENKKTK-ETRVVYHYHYLTWPDFGVPKAPGYflsfLFECRNagVLSSDVGPAVIHCSAGIGRSGTFVMIDSILAEV
 |.||  ...   ... . | ||.|.   | .|| | || | .|.| ||||.       ||.  .  ..     | |.||||||||| .|.  . .  ||
rfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshae....lfdlme..lvkksekPivvhcsaGiGrsvafigteylarev

EATgnlNAVDLGERLLAARQYRVGLIQTPDQLRFTS
||    . ..| | |   |. |   .||  || .  
ead...ptieltealkhlrehrwngvqtnsqlywmt
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 58-291 2.4e-32 106.8 In-house 39-283 (301) alignment 
Range on Protein: 58-291
Range on HMM: 39-283/301.0
ANRPLNRYRDVLPYDHSRIILESTQN----GTDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWPCG----
.|..|||.... .||. ||||. ..|     ..||||. ..     |..| ||||. .|   ||...|..   ...|. .  |. . ||.|||| .    
enkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaes

ERYAHVNCLELD-----SFQIKYIT---ENRS-EEFTVRILELENKKtkETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAGvLSSDVGPAVIHCSA
|.. .....  .     .| |. ..   .. | . .. | .. ...|  ... |  ..   ||. || . |   |  . .   .   . . || |.|||.
eefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprtvLqviddvihrq.qkigggpvvVHCSd

GIGRSGTFVMIDSILAEVEATGnlnAVDLGERLLAARQYRVGLIQTPDQLR
...|||... ..  |  . | |    ||. .   | |. . | ..| .|  
tVsrsGvYcsvsiglEQckaeg...VVdvfqvtkavrrskpgaVtTLeqyt
0051082 (Phosphotyrosine protein) phosphatases II 85-297 1.3e-29 98.1 In-house 3-149 (151) alignment 
Range on Protein: 85-297
Range on HMM: 3-149/151.0
TDYINANLVEfpelgKRYILAQGPLPhtadHFWQMVWENNSKAVIMLNKVMEKNqiKCFQYWPCGEryahvncleldsfqikyitenrseeftvrilele
.||||.. |.      .... .|||.    .|.....|.. |....|.. .| .  .| .|.|  .                                  
sdyinfsyvt.....gglyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

nkktketRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNagvlsSDVGPAVIHCSAGIGRSGTFVMIDSILAEveatgnlnaVDLGERLLAARQYRVGLI
       . |.|...| |||.|.|  .  .|.|| ....      . || ..|||||.||.||.|... .|           |.| | |   |..| |..
.......ievlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylmllg.........vsleealeeyrlkrpgvv

QTPDQLRFTSIAI
|...| .|  .|.
qpnqqflfqlfal
0044763 (Phosphotyrosine protein) phosphatases II 70-292 4.9e-29 96.6 In-house 1-162 (178) alignment 
Range on Protein: 70-292
Range on HMM: 1-162/178.0
PYDHSRIILESTQN--GTDYINANLVEfpelGKRYILAQGPlphtaDHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWPCGERyahvncleldsfqiky
|.|..| .|.. ..  ..|||||. .     .  |. ...|      .......|.. .....|.. .| ...||..||| ..                 
pldrtrvllsnleglersdyinaseil....pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

itenrseeftvrilelenkktketrvvYHYHYLTWPDFGVPKAPGYFLSFLFECRNAGV-LSsdvGPAVIHCSAGIGRSGTFVMIDSILAEveatgnlnA
                           ..|... .||.|||  . .|| |.  ...|        || ..|||||.|||||.|... ..           
...........................iqylhipipDhgvpdllehflefvefieealdekg...gpvlVHCsaGvgRsgtlvaaylmkkl........g

VDLGERLLAARQYRVgLIQTPDQLRF
..| | .   |..|   ...|.|||.
lsleeaielvrerRp.ivpnpgqlrq
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 60-267 5.4e-28 92.6 In-house 44-245 (312) alignment 
Range on Protein: 60-267
Range on HMM: 44-245/312.0
RPLNRYRDVLPYDHSRIILESTQNgtDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWpcGERYAHVNcLE
. |||| ..  .|  |. |   .|   || ||.|      .|.. .||||  |. ||||..    | ..|.|  ..|    || .|    .  . |. ||
kdlnrypniqcwdrgrftlagden..fyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyi..sdivgfvd.le

LDSFQIKYITE-----NRSEEFTVRILELENKKTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLfecrnaGVLSSDVGPAVIHCSAGIGRSGTFVMIDSI
      .| ||     .  .  | |.| .  | | .   . || . .||| |.| .    | .|        .  |  | . |||||.||.||...|.|.
dhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrll......savkkdkkpviahcsagvgrtgtlaliesm

LAEVEATGNLNAV
.| .    . |  
iaalrhprkqnvk
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 43-291 2.9e-27 90.5 In-house 27-261 (288) alignment 
Range on Protein: 43-291
Range on HMM: 27-261/288.0
QSRENAGKVAAAKLPANRPLNRYRDVLPYDHSRIILEstQNGTDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKC
.| ..| . .. .  ||   .||...   | .|. |.   .   ||.||.|   .  .| | || ||  | . .|.|. |.. . ..||....|| . | 
dspneasidiidsfianptrdryenlprcditrvkls..ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeks

FQYWPCGERY-AHVNCLeldSFQIKYITenRSEEFTVRILELENKKTKETRV-VYHYHYLTWPDFGVPKApgyFLSFLFECRnagVLSSDVGPAVIHCSA
 .|.|      |... |     ..|        . .|..  | ..|. |..| | . |.| |.| |||.    .||.|  .    || |   | |.|.||
aeyfPsklGekarigrl...ctvvkkkr..adidklvkvsllriskegeekvivkilhlleWdddgvPen...ylsplrlle...vlkslqkPivvhssa

GIGRSGTFVMIDSILAEVEATGNLNAVDLGERLlaaRQYRVGLIQTPDQLR
|.||.||...|  .|  .  . .|    | ..|   |. |   |||  |  
GvGrtgtlililialeslrlddflgirsllakl...reerfkaiqtemqyl
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 62-289 1.2e-25 84.7 In-house 55-278 (310) alignment 
Range on Protein: 62-289
Range on HMM: 55-278/310.0
LNRYRDVLPYDHSRIILESTQ-NGTDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWPC---GERYAHVNC
 ||| ||.  | ||. |.  .    ||| || |    | . .| .|||| ||   ||.|.... ......| ||.|. . ||  |||     | |  .  
knrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirv

LELDSFQIKYITENRSEEFTVRILELENK--KTKETRVVyHYHYLTWPDFGVPKAPGYFLSflfeCRNagVLSSDVGPAVIHCSAGIGRSGTFVMIDSIL
 .|     ..   | .  |    . ....  . || ||    ..  ||| |||    . .      |   .     || |.|||||..| .. | ..  .
tnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvs.likwpnwpdrgvpdekchtvp....qrl..laqvrhgpcvvhcsagkdrlyvvvalklki

AEVEATgnlNAVDLGERLLAARQYRVGLIQTPDQ
  ..     . ||. |     .. |.  |||. |
dkldrg...lkvdaeevktellksraiciqtelq
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 63-153 3.2e-25 83.6 In-house 51-157 (350) alignment 
Range on Protein: 63-153
Range on HMM: 51-157/350.0
NRYRDVLPYDHSRIILE----------STQNGTDYINANLVEFP------ELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYW
|||...|||.|||..|.           . .. |||||| .. .      . . .|| .|.||| | | |.... .|. | ...|.. .| |  || .||
nrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYW

PCGERYA
. |.   
qegsydd
PTPc_DSPc_SM00012 194-298 1.3e-24 81.8 In-house 2-104 (105) alignment 
Range on Protein: 194-298
Range on HMM: 2-104/105.0
VYHYHYLTWPDFGVPKAPGYFLSFLFECRNAGVLSSDVGPAVIHCSAGIGRSGTFVMIDSILAEVEATGnlNAVDLGERLLAARQYRVGLIQTPDQLRFT
|.||||..|||.|||. .  .|..| ....    |.. .| |.|||||.||.||||..| .|  .|..   . ||. . . . |..| |..|| .|  | 
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket..kevdifqivkelrkqRpgmvqteeqylfl

SIAIL
  |.|
yrall
subfamily_CG42327_pd Subfamily CG42327 57-224 4.4e-24 79.7 In-house 26-193 (319) alignment 
Range on Protein: 57-224
Range on HMM: 26-193/319.0
PANRPLNRYRDVLPYDHSRIILEST--QNGTDYINANLVEFPELG-KRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWPCGERYA
.. .. .|. .|.|  ..|..|..   .. . |..|. |  ..     || || .|  ..  ||..|||..|. .. | .. |.   .| .|.|  |   
vtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketld

hvNCLELDSFQIKYITENRSEEFTVRILELENKKTKETRVVYHYHYlTWPDFGVPKAPGYFLSFLFECRNA
  |      ...     .  ... .  | | . . .|.| . || |  |.. .||  .  ... |.| |..
..ntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 56-298 1.1e-23 78.6 In-house 32-267 (285) alignment 
Range on Protein: 56-298
Range on HMM: 32-267/285.0
LPANRPLNRYRDVLPYDHSRIILESTQngTDYINANLVEFPELGK-RYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWPcgERYAH
  ||  |||| ||   . .|..|.  .   ||| |. . .|   .  || .||||| |   ||.|.....   |.||  ..|    ||  |.|  |.   
yeanpdlnryadvrcieetrvvlknhd..rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyyp..eklge

VncLELDSFQIKyITENRSEEFTVRILE---LENKK--TKETRVVYHYHYLTWPDFGVPKAPGYFLSFlFecRNAGVLSSDVGPAVIHCSAGIGRSGTFV
|  ...  ..|  .|| . |  .  ||.   . | .  . |   . | .   |||   |.    .. . .  .    .     | ..|||||.||. |||
v..vkfgkyeit.lteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmiel.y..kwvkkvnpkekpicvhcsagvgrtatfv

MIDSILAEVEATGNLNAVDLGERLLAarqYRVGLIQTPDQLRFTSIAIL
 ||     .    |.. .|.   . |    |.  .|.  |. |  . ..
gidyatirimenpniemldivremra...mrfqavqshmqflflyvvlm
subfamily_eak_pd Subfamily eak 66-227 2e-23 77.3 In-house 58-213 (332) alignment 
Range on Protein: 66-227
Range on HMM: 58-213/332.0
RDVLPYDHSRIILESTQ-NGTDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWPCGERyahvNCLELDSFQ
 ...|||.  . | |.| |   |||| |.||.|.|..|||.  .       ||||| |..| |...| . .|..  |  .|.|   |    . |.   ..
vkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktr....eelkfGild

IKYITENRSEEFTVRILELenKKTKETRVVYHYHYLTWPDFGVPKAPGyFLSFLFECRNAGVL
..     . . . .| |||  .|  ||  |.||..  | .. .||    ||..    ...|||
verkefvkrniletrllel..skGnethrvlhykvfGwtettlpkyed.flalrkvmkevGvl
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 102-299 3.5e-23 77.0 In-house 37-219 (255) alignment 
Range on Protein: 102-299
Range on HMM: 37-219/255.0
YILaqgplphTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWPCgERYAHvncLELDSFQIkyITENRSEEFTVRILELENKK--TKETRVVYHYHY
|.|       | |.|.|..  .... |.||    |... || .|.|  |.  .   | |   ..  .| . | .  .| ||.  .    |.|. | ||.|
ysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfpl.ekdek...lkladvnv..tttkssadvvlrtleitstlgekkkthtvkhysy

LTWPDFGVPKAPGYFLSFLFECRNagvlsSdvGPAVIHCSAGIGRSGTFVMIDSILA------EVEATGNLNAVDLgerLLAARQYRVGLIQTPDQLRFT
  |..   |. .   |  |   |.     |   . |.|||.||||| .||.....        .   |..|. . |   |   |. | . |.|| || |.
kGWieknaPelareilnilkvvrd.....s..ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylsl...leelrskrkraihtPlqlafs

SIAILE
 . .|.
ilmvld
0048076 (Phosphotyrosine protein) phosphatases II 179-292 2.3e-22 74.7 In-house 32-134 (145) alignment 
Range on Protein: 179-292
Range on HMM: 32-134/145.0
RILELENKKTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNagVLSSDvGPAVIHCSAGIGRSGTFVMIDSILAeveatgnlNAVDLGERLLAARQ
..| | . .. ..| ...|.|| |||.|||  . ..|.||  ...  .|... || ..|||||.||.||.|... .|         . |.| | |   |.
tvlnltselellerlgiqylylpwpDhgvpdllellleflefiee..alkeg.gpvlVHCsaGvgRtgtlvaaylmll........lgvsleealelvrs

YRVGLIQTPDQLRF
.| | ...|.||||
qrpgavpnpgqlrf
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 100-287 1.4e-21 71.5 In-house 5-190 (199) alignment 
Range on Protein: 100-287
Range on HMM: 5-190/199.0
KRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWPCGERYAHvnCLELDSFQIKYITENRSEEFTVRILELENKKTKETRVVYHYHY
.||| .| || .|   |||||||  |  ..|.|    ...     |||. |  .        |   | || .     |. ||  .      || . || .
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtg..kygslsvttktittkpdytitaliltnnttappstreishyqf

LTWPDFGVPKApGYFLSFLFECRNAGVL--SSDVGPAVIHCSAGIGRSGTFVMIDSILAEVEAtGNLNAVDLGERLLAARQYRVGLIQTP
 .| .   |.    |. |.   |.           | ..||| | | .| || .|  .   |   .   ||| |     || |.|.| . 
tswkekttpnv.alfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrshee.sktsvvdlfevakrlrqarcgiissl
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 100-287 1.4e-21 71.6 In-house 4-189 (198) alignment 
Range on Protein: 100-287
Range on HMM: 4-189/198.0
KRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWPCGERYAHvnCLELDSFQIKYITENRSEEFTVRILELENKKTKETRVVYHYHY
.||| .| || .|   |||||||  |  ..|.|    ...     |||. |  .        |   | || .     |. ||  .      || . || .
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtg..kygslsvttktittkpdytitaliltnnttappstreishyqf

LTWPDFGVPKApGYFLSFLFECRNAGVL--SSDVGPAVIHCSAGIGRSGTFVMIDSILAEVEAtGNLNAVDLGERLLAARQYRVGLIQTP
 .| .   |.    |. |.   |.           | ..||| | | .| || .|  .   |   .   ||| |     || |.|.| . 
tswkekttpnv.alfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrshee.sktsvvdlfevakrlrqarcgiissl
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 51-295 1.5e-21 71.3 In-house 39-273 (303) alignment 
Range on Protein: 51-295
Range on HMM: 39-273/303.0
VAAAKLPANRPLNRYRDVLPYDHSRIILEStqngTDYINANLVEFpELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWPCGE
|.  ..  |   ||. ||.  |||.. |      . || |. .|. .  |. ||.| ||.|||  ||||. |.. | |..|    | ...     .|  .
vsknqfvknmdknrfvdvicldhskvklsd....ssyihasylel.dsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnq

RYAHVNCLELDSFQIKYIteNRSEEFTVRILELENKKTKETrvVYHYHYLTWPDFGVPKA-PGYFLSFLFECRNAGVLSSDVGPAVIHCSAGIGRSGTFV
 . . .   .   ..| .  . .. .....| . | . |    .. .|| .||   .|      |.  ... .      ||  |.|    .| ||.||| 
dflkfeersirvgefkrv..elgdgwvlkvlsvsngdyksf..lhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfa

MIDSilAEVEATGNLNAVDLGERLLAARQYRVGLIQTPDQLRFTSI
....  | .    . ...||   |   |. |.  .|   |. .   
lfet..ahlslhseqasldlvkclenvrngrlhavqnlsqfsvvyt
0048179 (Phosphotyrosine protein) phosphatases II 148-292 2.3e-21 71.5 In-house 13-136 (144) alignment 
Range on Protein: 148-292
Range on HMM: 13-136/144.0
CGERYAHVNCLELDSFQIKYITENRSEEftvrilE------LenkktketrvVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAgvLSSDvGPAVIHCSAG
 |  .. ..  .| ...|...   ..|       |                 ...|..| |||.|||  . ..|.||  ...|  |... || ..|||||
lgslptaldlellkklgittvinlteey......epeflere..........giqylhlpwpDhgvpdllellleflefieea..leeg.gpvlVHCsaG

IGRSGTFVMIDSILaeveatgnLNAVDLGERLLAARQYRVGLIQTPDQLRF
.||.||.|... ..        .. ..| | |   |..| | ...|.||||
vgRtgtlvaaylmk........klglsleealalvrsrrpgavpnpgqlrf
subfamily_hpo-7_pd Subfamily hpo-7 102-300 3.3e-19 63.8 In-house 40-226 (263) alignment 
Range on Protein: 102-300
Range on HMM: 40-226/263.0
YILaqgpLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWPCgERYAHVNcleLDSFQIkyITENRSEEFTVRILELEN--KKTKETRVVYHYHY
|.|    |  | | |.|..  .... |.||    |... || .|.|  |.        |   ..   | .  ..  .. ||| .  .. |.|. | || |
ysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPl.ekdekqk...lanvnv..cttkvqsdvllktlellstlgeKkkthtvkhysy

LTWPDFGVPKAPGYFLSFLFECRNagvlssdVGPAVIHCSAGIGRSGTFVMIDSILA------EVEATGNLNAVDLgerLLAARQYRVGLIQTPDQLRFT
  |..   |. .   |  |   ||         . |.|||.|||||  |......        .   |..|. . |   |   |. | . |.|| || |.
kgWiekndpelareilnilkvarn.......skslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsL...leelrssrkraihtPmqLafs

SIAILEG
 . .|. 
ilmvLdf
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 82-298 3.4e-19 64.1 In-house 43-256 (290) alignment 
Range on Protein: 82-298
Range on HMM: 43-256/290.0
QNGTDYINANLVEFPElGKRYILAQGPLPHT-------ADHFWQMVWENNSKAVIMLNKVMEKNQI----KCFQYWPcgerYAHVNCLELDSFQIKYITE
.   ||| || | .|. | | || | |. ..         .|| |. . ..| |.|| ...||..      | .| |     .  . | .. ...|    
rfnddyiHAnrvtcpn.glrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvp....esvgeelkfkgltvkCksk

NRSEEFTVRILELENKKTKETRvVYHYHYLTWPDFGVPKAPGYFLSFLFEcrnagvLSSDVGPAVIHCSAGIGRSGTFVMIDsiLAEVEATGNLNAVDLG
   ... .| |...  . .|   | |. .  | .  |.. .  .|| .        .     |...||  || || ..  |.  |.     .  ..| | 
ekeddvetRelvvkfddeeeft.vtHsllkgWnklnvqedtktllsliqk......vkasktpvivHcvdGiSrsAalaaii..lgyQkiaetsgsvkle

ERLLAARQYRVGLIQTPDQLRFTSIAIL
. | | |. |  .|... .| |   .|.
dvlkalrkqralaitsalelafvdagiv
subfamily_egg_pd Subfamily egg 64-256 4.3e-19 63.3 In-house 45-226 (307) alignment 
Range on Protein: 64-256
Range on HMM: 45-226/307.0
RYRDVLPYDHSRIILES--TQNGTDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNqiKCFQYWPCGERYAHVNCleLD
| . |   | ||. ||    |   |.| || |.   |   .|||| ||  | | ||.||.... . ..||.   | .  .|  |||  |  . |      
rskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkese..rceyywpkaesdslvtv..pG

SFQIKYITE--NRSEEFTVRILELeNKKTKETRVVYHYHYlTWPDFGVPKAPgyfLSFLFECRNAgvlSSdvgPAVIHCSAGIGRSGTFVMIDSILA
|..|. .    .    |.|  | |     .| | . |. .  .   .    |   |  |   ||.   |    |.|...  |. ...|.| |.  | 
slrienlkvdskadplfrvtklkl.vGgddeerflehwqg.dvnnssdvysp...lrvlrklrnl...sk...pvvvqdilGvskaatlvaieiall
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 190-302 6.5e-18 59.3 In-house 87-195 (440) alignment 
Range on Protein: 190-302
Range on HMM: 87-195/440.0
ETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAgVLSSDVGPAVIHCSAGIGRSGTFVMIDSILAEVEATGNlnaVDLGERLLAARQYRVGLIQTPDQ
|.|.. .|||  ||| ||||  |  | .. .  ..    .  || ..||||| ||.|  . .|||| |.. . .   .|.   . . |. |  ..|||.|
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnes.qekagngpllvhcsagagrtgviiavdsilreakrsdq...idifsfinsmrnnrpqmvqtpeq

LRFTSIAILEGTL
  |   |.||| |
yafvheavlegll
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 102-301 1.7e-17 57.9 In-house 76-288 (302) alignment 
Range on Protein: 102-301
Range on HMM: 76-288/302.0
YILAQGPL-----------------PHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQYWPC--GERYaHVNCLELDSFQIKYITENR--SEEFTVRI
.|.||||.                   | . .| .. . |   |. | ...|... || .|.    |..  . .   . . ..|   |.    ..|..  
wimaqGpmdGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggel.kfgrytvktvsvktdleeftdkksfklyt

LELENKKTK--ETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNagvLSSDVgpaVIHCSAGIGRSGTFVMIDSilaEVEATGNLNAVDLGERLLAARQ
.|..|.|.|    . |   .. .||| | || . . |  |  |        .|   ..|||||.||.||.| |      ..   . .  || . .|  ||
veiknekkkkkvkktvdilafsawpdhGapkeaytaldilkfces...ykknv...lvhcsaGvGrtGtlvaiky...Giqlcskkkvtdllsivlpvrq

YRVGLIQTPDQLRFTSIAILEGT
 | | .|. .|| .  . .  | 
cryGavqdeqqliylllcvtkgl
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 63-186 1.4e-16 54.8 In-house 52-193 (349) alignment 
Range on Protein: 63-186
Range on HMM: 52-193/349.0
NRYRDVLPYDHSRIILESTQN----------------GTDYINANLVEFPEL--GKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQ
|||.|.|||.|||..|. . .                  |||||| ......   |.||  | ||| | | |....  |. | |. ||.  |..  || .
nrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdi

YWPCGERYAHVNCLELDSFQIKYITENRSEEFTVRILELENK
||  ..   .   |   | .|  .  | .. .||.  . .|.
ywqelsysnitvklqnsslyianvqGnslrvstvkdtdndnd
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 59-297 2.6e-16 53.9 In-house 51-281 (302) alignment 
Range on Protein: 59-297
Range on HMM: 51-281/302.0
NRPLNRYRDVLPYDHSRIILESTQngTDYINANLVEFPELGKRYILAQGPLPHTA---DHFWQMVWENNSKAVIMLNKVMEKNQiKCFQYWP-CGERYAH
|   |.  ||  .|. ...|| ..   .|.||  || |||..  |||| |   ..   ..||.||.... . | .| .  | ..    ...|   . | .
nlkknqsedvpildsnlvkleaep..dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdyke

VNCLELDSFQIKYITENRsEEFTVRILElenKKTKETRVVYHYHYLTWPDFGVPKAPGYFLSFLFECrNAGVLSSDvGPAVIHCSAGIGRSGTFVMIDSI
 . . .   ....  |.. ..... .|    .   .. ..  |.   |..  ||.  .       .   |   ..|  ..||    |.|| |.|.     
ygkmfvNnrkVekaeeek.tryviEvlP...egcsnsvlanvyvltnWkqkkvpvkyaeliktaakv.fakkikad.entvivSknGaGRagafltlava

LAEVEATgnlNAVDLGERLLAARQYRVGLIQTPDQLRFTSIAI
. ....    ...   | . . |. |   ... .|  .. ||.
veklqkg...kepnikeivksiRsqRpravdslkQyvslyial
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 53-151 3e-12 40.7 In-house 90-183 (244) alignment 
Range on Protein: 53-151
Range on HMM: 90-183/244.0
AAKLPANRPLNRYRDVLPYDHSRIILESTQNGTDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNqikcfQYWPCGER
 |  | |   ||    ||.| .|. |     |  |||| .|        |||.| ||  |.  ||.|. |   . ...|  | |..     .|||  | 
dafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed.....eywpdsep
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 192-262 1.1e-10 35.8 In-house 215-293 (350) alignment 
Range on Protein: 192-262
Range on HMM: 215-293/350.0
RVVYHYHYLTWPDFGVPKAPGYFLSFLF--------ECRNAGVLSSDVGPAVIHCSAGIGRSGTFVMIDSILAEVEATG
 |||. ..  |.| ..   |  .|. |          . .  . ..   | ..|||||.|| ||.| .||.| ..|   
yvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeile
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 54-213 4.8e-10 32.6 In-house 22-160 (169) alignment 
Range on Protein: 54-213
Range on HMM: 22-160/169.0
AKLPANRPLNRYRDVLPYDHSRIILEST--QNGTDYINAnlvefpelgkryilaqgplphtadhfwQMVWENNSKAVIMLNKVMEKNQI----KCFQYWP
|.| .|   ||    |   | |. |.    . |.|||||                           .|.|| |.  ...|    .||..    . .|  |
aeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddknnfwpekedyqlhp

C---GERYAHVNCLELDSFQIKyiTENRSEEFTVRILeLENKKTKETRVVYHYHYLTWPDFGVPKAPGY
    || |.    .  | .. .  |.     | | .. . . . . |  .  .|| |||. |||..| .
avilgewytdslyvrtdkvhan..tsgveglfevsmv.ihsydddvteklsllhystwpqngvpqspvh
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 54-214 1.2e-09 31.2 In-house 21-160 (169) alignment 
Range on Protein: 54-214
Range on HMM: 21-160/169.0
AKLPANRPLNRYRDVLPYDHSRIILEST--QNGTDYINAnlvefpelgkryilaqgplphtadhfwQMVWENNSKAVIMLNKVMEKNQI----KCFQYWP
|.| .|   ||    |   | |. |.    . |.|||||                           .|.|| |.  ...|    .||..    . .|  |
aeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddknnfwpekedyqlhp

C---GERYAHVNCLELDSFQIKyiTENRSEEFTVRILeLENKKTKETRVVYHYHYLTWPDFGVPKAPGYF
    || |.    .  | .. .  |      | | .. ... . . |. .  .|| |||. |||..| . 
avilGewytdslyvrtdkvhpn..tsgveglfevslv.ihsydddvteqlsllhystwpqngvpqspvhv
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 55-141 5.8e-09 29.9 In-house 30-117 (332) alignment 
Range on Protein: 55-141
Range on HMM: 30-117/332.0
KLPANRPLNRYRDVLPYDHSRIILESTQNGTDYINANLVEFPELGKRYILAQGPLP-HTADHFWQMVWENNSKAVIMLNKVMEKNQIK
|.  |  .||   .  .||||. |   .   |. ||. |.       ||.|| |.  ||   ||.|| | .   ....  . ||.. |
kflnnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 63-144 9.5e-09 29.2 In-house 41-129 (347) alignment 
Range on Protein: 63-144
Range on HMM: 41-129/347.0
NRYRDVLPYDHSRIILE--S-----TQNGTDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNQIKCFQ
|| .||   | .|..|         ...   ||||  . | .  | |||.| |||.|   ||.||   .   |. . . .. . |. |.
nrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikdeaieefa
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 69-152 2.2e-08 28.4 In-house 3-75 (130) alignment 
Range on Protein: 69-152
Range on HMM: 3-75/130.0
LPYDHSRIIlestqnGTDYINANLVEFPELGKRYILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKNqikcfQYWPCGERY
|... ||.       | .||||..|   .  . |.|.| ||  |. .||.|. |     ...|  | |..     .|||  | .
lefevsrlq......gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed.....eywpdsePl
subfamily_CG42327_pd Subfamily CG42327 229-293 2.7e-08 27.9 In-house 245-307 (319) alignment 
Range on Protein: 229-293
Range on HMM: 245-307/319.0
SDVGPAVIHCSAGIGRSGTFVMIDSILAEVEATGnlNAVDLGERLLAARQYRVGLIQTPDQLRFT
.. || |.||| |.||.|. .  |  . ..| .   ..||. . .   |. |   ..| .|  | 
esqGPlvvhcsdGvGrtGlviasdiairsleesk..rsvdiPqlvssvrrdrasavltkeqyefi
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 56-107 1.3e-07 25.6 In-house 45-95 (95) alignment 
Range on Protein: 56-107
Range on HMM: 45-95/95.0
LPANRPLNRYRDVLPYDHSRIILeSTQNGTDYINANLVEFPELGKRYILAQG
  || | ||. ...||| .|..| .|.  .||||| .|.     . || |||
seanipknrflnifpydatrvvl.ttkrdsdyinacfvdgyarkncyiaaqg
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 229-261 5.1e-07 23.3 In-house 263-295 (349) alignment 
Range on Protein: 229-261
Range on HMM: 263-295/349.0
SDVGPAVIHCSAGIGRSGTFVMIDSILAEVEAT
... . ..||||| ||.|..| .|..|. .| .
dqlstllvhcsaGcGrtGvlvtldlllsilepl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 233-298 6.7e-07 23.4 In-house 230-292 (297) alignment 
Range on Protein: 233-298
Range on HMM: 230-292/297.0
PAVIHCSAGIGRSGTFVMIDSILAEVEAtGNLNavDLGERLLAARQYRVGLIQTPDQLRFTSIAIL
. ..|||||.||||  |. | ||| .   . .   |    |   |. |  |.|| .|  .   |.|
yllvhcsaGvGrsGvvvlsdvilaklrk.krip..dvaailsilreqrarlvqtleqfellydavl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 53-94 6.9e-07 22.9 In-house 41-84 (440) alignment 
Range on Protein: 53-94
Range on HMM: 41-84/440.0
AAKLPANRPLNRYRDVLPYDHSRIILESTQN--GTDYINANLVE
 | || |.  ||||..| |||||..||  .    .|||||  ..
iaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyin
PTEN_1 190-249 1.3e-06 23.4 In-house 90-148 (196) alignment 
Range on Protein: 190-249
Range on HMM: 90-148/196.0
ETRVVYHYHYLTWPDFGVPKapgyFLSFLFECRNAGVLSS---DVGPAVIHCSAGIGRSGTFV
. .  . |. . ..|.|.|     . ... .|...    .   . . ...|| ||.||||| |
ffksgveylhfpieDhgaps....lselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvv
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 102-186 2.3e-06 21.2 In-house 238-314 (440) alignment 
Range on Protein: 102-186
Range on HMM: 238-314/440.0
YILAQGPLPHTADHFWQMVWENNSKAVIMLNKVMEKnqiKCFQYWPCGERyahvnCLELDSFQIKYITENRSEEFTVRILELENK
.| .| ||  |   ||..| . .  ..||||.. .|    |  |||   |      . .  | . .   .  .   || |||  |
fiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntr.....svtfgpftvghkgsenmnrvkvrtlelkyk
0038934 (Phosphotyrosine protein) phosphatases II 191-249 2.4e-06 22.8 In-house 76-133 (194) alignment 
Range on Protein: 191-249
Range on HMM: 76-133/194.0
TRVVYHYHYLTWPDFGVPKAPGYFLSFLFECRNAGVLSSDvGPAVIHCSAGIGRSGTFV
... ..|. | .||.|..      |.||  .      ... |  ..|| ||.||.||.|
ekagieylklpfpddgtvPsleillrfldlvdeflnedpg.gvvaVHCkaGlgRtGtlv