Gene PTPN12 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN12
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP072_AA protein Get Run
NvecP072_AA_11-290 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN12_pd Subfamily PTPN12 15-296 4e-135 444.3 In-house 2-284 (290) alignment
Range on Protein: 15-296
Range on HMM: 2-284/290.0
NNPQGENGFAKEFQELKNISSRQKRDKAFSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWR
.. .||. ||||||.||..|...|..|..||..||||.|..|||||||||||.||..| .|....||||||.|.|||......|.|||||||||.|||||
eekegeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWr

MMISHNIQVVVMACREYELGKLKCKRYWPESMEETLTFAGMKISLESEEAMGDGFTVRTLAVQAGKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRT
|....|...|||||||.|||| ||.|||||..||.|.|. ....||.|.|. |.|..|||.|.| |....|.||||||||||.||.||..|.||....|.
miweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvre

FVGSQDTPVLVHCSAGCGRTGTICALDYARTLLQTGRT-EELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVNEELRKQ
.  |.|.|..||||||.||||||.|.||.|.||..... |||.|||.|..||.||.|.|||||||.||||||.|||..||.  
lqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkeleii

subfamily_PTPRD_pd Subfamily PTPRD 22-291 4.4e-92 304.5 In-house 21-283 (564) alignment
Range on Protein: 22-291
Range on HMM: 21-283/564.0
GFAKEFQELKNISSRqkrdKAFSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNI
. .| ..| |.|...    . |.... .|. |. ||||..|..|| ||.|| ...|..|||||| ..|.| .|.  |.|.||||..|..|||||.  .|.
sdlkfeeeykkieeg....qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqns

QVVVMACREYELGKLKCKRYWPESmEeTLTFAGMKISLESEEAMGDgFTVRTLAVQAG--KTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGSQ
...||  .  | || ||..||||. . | |. .....||.|| . | ...||. ..    . ...|.|||.|.||||.|| |||.|..| |  |.   ..
stiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeelad.yeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepd

DTPVLVHCSAGCGRTGTICALDYArtLLQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVNE
  |..|||||| ||||| ...|.   | .    . . .. .|..||.|| |||||.|||  ...|. | .. 
agPivVhCSaGVGRTGtfividam..lerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealac

0051299 (Phosphotyrosine protein) phosphatases II 17-288 6.5e-91 300.0 In-house 19-285 (288) alignment
Range on Protein: 17-288
Range on HMM: 19-285/288.0
PQGENGFAKEFQELKNISSRqkrdkaFSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMM
. | .|...||.|| ..         ...... .. |..||||.||||||.||..|  ..||.|||||| .||.|. ..  ..|.|||||.||.|||||.
angltglleefeellsllpd......ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmv

ISHNIQVVVMACREYELGKLKCKRYWPEsmEETLTFAGMKISLESEEAmGDGFTVRTLAVQ------AGKTKHNVTQFHYTAWPDHDVPRSATPLIELTR
  .|..|.|| ....|||. || .|||.  ...||.  ... | |||   |..||||| |.       ......||.||||.||||.|| |...|... |
weqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflr

SFRTFVGSQDTPVLVHCSAGCGRTGTICALDYARTLLQTGrtEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEEL
 .|..  |.. ||.||||||.|||||..|||..  .|...  ....|...|. ||.||  |||| ||| .||.|. |.
lvrkalasgggpvvVHCsaGvgRtgtfialdllleqleke..ggvdvleavkrlreqRpgmvqtpeqyrfvyealley

0050432 (Phosphotyrosine protein) phosphatases II 14-290 2.8e-90 298.0 In-house 35-300 (308) alignment
Range on Protein: 14-290
Range on HMM: 35-300/308.0
RNNPQGENGFAKEFQELKNISSrqkrdkAFSTNHGEKEYNRTKNRYKDILPYDYSRIVLpeikGvDGSDYINGNYIKGP--TKNIMYLAAQGPLPKTVDD
 ... .  .. .||.|| ..         ......... |..|||||||||||.||..|    . .|||||| .|..|.   ..  ..|.|||||.||.|
lekaldlglleeefeellsvkp......lleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatqgPlpntved

FWRMMISHNIQVVVMACREYELGKLKCKRYWPESME-ETLTFAGMKISLESEEAmGDGFTVRTLAVQA--GKTKHNVTQFHYTAWPDHDVPRSATPLIEL
||||.  .|..|.|| ....| |. || .|||.... ..|.. .... | |||   |..||||| ..   ..  . ||.||||.||||.|| |...|...
FwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldf

TRSFRTFVgsQDTPVLVHCSAGCGRTGTICALDYARTLLQTGrtEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVN
 .  |..   .. |..||||||.|||||..|||..  .|...   ...||..|. ||.||  ||||.||| ..|.|. |...
lelvrksl..pggpivVHCsaGvGRtGtfialdllleqleke..ggvdvfeavkklReqRpgmvqtpeqylflyralleylk

0046845 (Phosphotyrosine protein) phosphatases II 22-290 4.8e-88 290.5 In-house 1-275 (284) alignment
Range on Protein: 22-290
Range on HMM: 1-275/284.0
GFAKEFQELKNISSRQKrdkaFSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGV-DGSDYINGNYIKGP-----TKNIMYLAAQGPLPKTVDDFWRM
|. .||.|| ..   .     .|.... .. |..|||||||||||.||..|  ..|  ..||||| .|..|.      ..  ..|.|||||.||.|||||
gleeefeellsltvkll....lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrm

MISHNIQVVVMACREYELGKLKCKRYWPESmEETLTFAGMKISLESEEAmGDGFTVRTLAVQA---GKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSF
.  .|..|.|| ... | |. || .|||.. .|.||. .... | |||   |..||||| ..    ..  . ||.||||.||||.|| |...|.|. |  
vweqnvrvIVmltelvengrekcaqYwple.gevltygdftvtllseev.kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlv

RTFVG--SQDTPVLVHCSAGCGRTGTICALDYARTLLQTGR-TEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVN
|..    ... |..||||||.|||||..|||.. ..|.... . ...|...|. ||.||  |||| ||| .||.|. |...
rellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylk

0040438 (Phosphotyrosine protein) phosphatases II 19-290 8.5e-88 289.9 In-house 16-277 (317) alignment
Range on Protein: 19-290
Range on HMM: 16-277/317.0
GENGFAKEFQELKNIssrqkrdKAFSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMIS
. ... .||..| ..       |  .....|.. |. ||||.||||||.||..|  ..|. .||||| .|..|| ..  ..|.|||||.||.|||||.  
dftalleefedllsl.......kldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvwe

HNIQVVVMACREYELGKLKCKRYWPEsmEETLTFAGMKISLESEEAmGDGFTVRTLAVQ--AGKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFV
....|.|| ... |||. || .|||.  .||||. .... | |||   .|.|.||| |.   ..... ||.||||.||||.|| | ..|... .  |.. 
qgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreal

GSQDTPVLVHCSAGCGRTGTICALDYARTLLQTGRteELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVN
 ....|||||||||.|||||..|....  .|....  ...|...|. ||.||  .||| |||  .|.|. |...
edpggpvlVHCsaGvgRtGtfiaaylmleqlekeg..gvdveeavkelreqRpgavqtpeqyrflydalleylk

0036941 (Phosphotyrosine protein) phosphatases II 18-290 1.4e-87 289.0 In-house 10-278 (297) alignment
Range on Protein: 18-290
Range on HMM: 10-278/297.0
QGENGFAKEFQELknissrQKRDKAFSTNHGEKEYNRTKNRYKDILPYDYSRIVLpeikGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMI
 . ... |||.||      ... . .|....... |..|||||||||||..|..|    . .||||||..|..|.  .  ..|.|||||.||.|||||. 
lflalllkefeel......lpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvw

SHNIQVVVMACREYELGKLKCKRYWPESMEETLTFAGMKISLESEEAM-GDGFTVRTLAVQA--GKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRT
 .|..|.|| ....|||. || .|||. ..|.||. .... | |.| .  |..|.||| |.   .. .. ||.|||| ||||.|| |...|... . .|.
eqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrk

FVGS--QDTPVLVHCSAGCGRTGTICALDYARTLLQTG-RTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVN
.     ...|||||||||.||.||..|.|..  .|... ..........|  ||.||  .||| |||  .| |. ||..
vlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellk

0047943 (Phosphotyrosine protein) phosphatases II 15-287 5.6e-86 283.7 In-house 6-270 (273) alignment
Range on Protein: 15-287
Range on HMM: 6-270/273.0
NNPQGENGFAKEFQELKNISSrqkrdkAFSTNHGEKEYNRTKNRYKDILPYDYSRIVLpeikGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWR
... | .....||..|...         ......... |..|||||||||||.||..|    | .|||||| .|..|. ..  ..|.|||||.||.||||
ekllgltllleefelllslkp......lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwr

MMISHNIQVVVMACREYELGKLKCKRYWPESMEE-TLTFAGMKISLESEEAmGDGFTVRTLAVQA--GKTKHNVTQFHYTAWPDHDVPRSATPLIELTRS
|.  .|..|.|| ....|||. || .|||....| .||.  ... | |||   |..||||| ..    . .. ||.|||| ||||.|| | ..|.|. . 
mvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet.kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefiel

FRTFVGS--QDTPVLVHCSAGCGRTGTICALDYARTLLQTGrtEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEE
 |..  .  ...||.||||||.|||||..|||..  .|...   ...|...|. ||.||  |||| ||| ..|.|. |
vrkalealpsngpvvVHCsaGvgRtgtfialdllldqleke..ggvdvleavkllrsqRpgmvqtpeqyrflyealle

DSPc_SM00195 23-289 7.6e-86 283.1 In-house 2-262 (263) alignment
Range on Protein: 23-289
Range on HMM: 2-262/263.0
FAKEFQELKNISSRQkrdkafSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQ
. .||..|..  | .      .|...||. |..|||||.||||| .|. |..... .|||||| |||||..|.  | |.|||||.||.|||||.. ....
lkeefekleestspk......etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvk

VVVMACREYELGKLKCKRYWPESMEETLTFAGMKISLESEEAMGDGFTVRTLAVQAGK--TKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGSQD
..|| ..| | || ||.|||||..... ||  ... | ..| . | ...||| ... .  ....|||..|..||||.|| |.....|| |....   ...
iivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstss

TPVLVHCSAGCGRTGTICALDYARTLLQTGRTeeLSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELV
.|..||||||.|||||....|..   |... .  ...|.|| .|| ||  ||||.|||. .|.|. |..
gpivVhCsaGvgRtgtfvtidiilskleeekk..vdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 23-289 7.6e-86 283.1 In-house 2-262 (263) alignment
Range on Protein: 23-289
Range on HMM: 2-262/263.0
FAKEFQELKNISSRQkrdkafSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQ
. .||..|..  | .      .|...||. |..|||||.||||| .|. |..... .|||||| |||||..|.  | |.|||||.||.|||||.. ....
lkeefekleestspk......etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvk

VVVMACREYELGKLKCKRYWPESMEETLTFAGMKISLESEEAMGDGFTVRTLAVQAGK--TKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGSQD
..|| ..| | || ||.|||||..... ||  ... | ..| . | ...||| ... .  ....|||..|..||||.|| |.....|| |....   ...
iivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstss

TPVLVHCSAGCGRTGTICALDYARTLLQTGRTeeLSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELV
.|..||||||.|||||....|..   |... .  ...|.|| .|| ||  ||||.|||. .|.|. |..
gpivVhCsaGvgRtgtfvtidiilskleeekk..vdifeivkelRkqRpgmvqtleqYlfiyeaileyi

0045450 (Phosphotyrosine protein) phosphatases II 17-289 6.3e-85 280.9 In-house 23-304 (307) alignment
Range on Protein: 17-289
Range on HMM: 23-304/307.0
PQGENGFAKEFQELKNISSRQkrdkAFSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGV-DGSDYINGNYI--------KGPTKNIMYLAAQGPLPK
. . .|..|||..|...  .      ......... |..|||||||||||..|..|  ..|  ..|||||..|.        .|. ..  ..|.|||||.
ldfltgllkefekllsvtvfl....lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpe

TVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESmEETLTFAGMKISLESEEAmGDGFTVRTLAVQ---AGKTKHNVTQFHYTAWPDHDVPRSATP
||.|||||.  ....|.|| ... |||. || .|||.. .|.||.  ... | |||   ||.||||| |.     .  . ||.||||.||||.|| |  .
tvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfee

LIELTRSFRTFVGS--QDTPVLVHCSAGCGRTGTICALDYARTLLQTGRTEE-LSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELV
|... .  |.....  ...|||||||||.|||||..|.... ..|... | . ......|. ||.||  .||. |||  .|.|. ||.
lldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell

subfamily_PTPRB_pd Subfamily PTPRB 17-292 2.6e-84 277.7 In-house 21-288 (293) alignment
Range on Protein: 17-292
Range on HMM: 21-288/293.0
PQGENGFAKEFQELKNISSRQKRDKAfstnhgEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMM
 . . .|..|..|||.. . |. ..|      |.. ||.||||..|||||.||. | ..|. .|||||| |||.| . .  ..|.|||||.||||||||.
adsdlrfseeyeelkavgkdqavkaa......elavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmv

ISHNIQVVVMACREYELGKLKCKRYWPESMEETlTFAGMKISLESEEAMgDGFTVRTLAVQAGKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFV
  .. ...||  .  | || ||..|||.  |.. ..  .|..| .|| . . ...|.|... .|....|.|.|.|.||||.|| ....|....| .|. .
wekkssiivmltqlvekgkvkCeeYWPadeepv.lyGdikvtlvaeeel.edwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvreai

--GSQDTPVLVHCSAGCGRTGTICALDyaRTLLQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVNEE
   ....|..|||||| |||||  |||  | | .  ... . .| |||.||..|. .|||..||  ....| .|....
ektaskrPivvhCsaGvGRtGtfiald..rllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkk

0039614 (Phosphotyrosine protein) phosphatases II 12-290 2.4e-83 275.3 In-house 23-290 (297) alignment
Range on Protein: 12-290
Range on HMM: 23-290/297.0
EPRNNPQGENGFAKEFQELKNISSrqkrdkafSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGV-DGSDYINGNYIKGPTK-NIMYLAAQGPLPKTV
  .... . ... .||.||...          .. ..... |..|||||||||||.||..|  ..||  .||||| .|..|. . .  ..|.|||||.||
lllekansktllllefeellslkp........dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetv

DDFWRMMISHNIQVVVMACREYELGKlKCKRYWPESMEetlTFAGMKISLESEEAmGDGFTVRTLAVQAGKTKHNVTQFHYTAWPDHDVPRSATPLIELT
.|||||.  ....|.|| ... |||. || .||||...   |. .... | ..|   ||.||||| |. ..  . ||.|.|| ||||.|| |.. |.|. 
edFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkveh.ldgytvrtlevtnngesrtvthfqytgwpdhgvppslelllefl

RSFRTFVGS--QDTPVLVHCSAGCGRTGTICALDYARTLLQTGrtEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVN
.  |... .  ...|||||||||.|||||..|.... ..|...   ...|...|. ||.||  .||| .||  .|.|. ||..
elvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqleke..ggvdvleavkelreqRpgavqtpsqyrflydallellk

0043336 (Phosphotyrosine protein) phosphatases II 21-288 2.4e-82 271.8 In-house 20-276 (278) alignment
Range on Protein: 21-288
Range on HMM: 20-276/278.0
NGFAKEFQELKNISSrqkrdkaFSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHN
 .. .||.|| ..         ......... |..|||||||||||.||..|  ..|. .||||| .|..|. ..  ..|.|||||.||.|||||.  ..
tllllefeellsfkl.......dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelg

IQVVVMACREYELGKLKCKRYWPesmEETLTFAGMKISLESEEAmGDGFTVRTLAVQ--AGKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGS
....|| ... |||. || .|||   ...||. .... | .||   |..||||| |     . .. ||..||..||||.|| | ..|... . .|... .
vttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeeh.lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealed

QDTPVLVHCSAGCGRTGTICALDYARTLLQTGRteELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEEL
...|||||||||.|||||..||... ..|....  .......|. ||.||  .||| .||  .|.|. |.
sngpvlVHCsaGvgRTGtfialyllleqlekeg..gvdleeavkelreqRpgavqtpsqyrflyealley

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 18-291 3.1e-80 264.6 In-house 17-282 (318) alignment
Range on Protein: 18-291
Range on HMM: 17-282/318.0
QGENGFAKEFQELknissrQKRDKAFSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMI
.||  . .|...|      .. .. ... .  .. |..|||| .||.|| .|. | ...|. |||||| ||| | ...  |.|||.|||.|..|||||. 
sGelllseeyerl......srseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvW

SHNIQVVVMACREYELGKLKCKRYWPESmeETLTFAGMKISLESEEAMGDgFTVRTLAVQAGKT--KHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTF
  | .|.||  .| | || |..||||..  .. ..  ... |..|  ..| ...|.. |.  ..  . .| |.|||.|||..|| |.. |..| |. .. 
eqnsavivmltqeeergkakvhryWPsk..gsrsygklvvelkeevelsd.yvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvska

V-GSQDTPVLVHCSAGCGRTGTICALDYartLLQTGRT-EELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVNE
   |. .|..|||||| ||||. .|.|    ||.  .  . . ||..| .||.|| .||||..||...|... | .. 
qqksgagpivvhCsaGvGrtGvfiavdi...llerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealas

Y_phosphatase Protein-tyrosine phosphatase 53-286 6.9e-80 263.2 Pfam-A 1-234 (235) alignment
Range on Protein: 53-286
Range on HMM: 1-234/235.0
NRTKNRYKDILPYDYSRIVLpeiKGVDG-SDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESMEETLT
|..||||||||||| .|. |   || .| ||||| ||.|| ... ...|.||||..|..|||||.. ....|.|| ... | |. ||..||||..||.||
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FAGMKISLE-SEEAMGDGFTVRTLAVQAGKTKH---NVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGSQDTPVLVHCSAGCGRTGTICALDYARTLL
.  .|. |. .|..  ...|.|.| ..  |...    |.|.|||.||||.||.|...|..| |....   ....||.||||||.|||||..|||..   |
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

QTGRTeeLSVFDIVANLRRQRVAMVQTKEQYTLVYKAVE
.....  ..|..|| .||.||  |||. |||  .|||. 
eaeee..vdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 53-286 6.9e-80 263.2 In-house 1-234 (235) alignment
Range on Protein: 53-286
Range on HMM: 1-234/235.0
NRTKNRYKDILPYDYSRIVLpeiKGVDG-SDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESMEETLT
|..||||||||||| .|. |   || .| ||||| ||.|| ... ...|.||||..|..|||||.. ....|.|| ... | |. ||..||||..||.||
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FAGMKISLE-SEEAMGDGFTVRTLAVQAGKTKH---NVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGSQDTPVLVHCSAGCGRTGTICALDYARTLL
.  .|. |. .|..  ...|.|.| ..  |...    |.|.|||.||||.||.|...|..| |....   ....||.||||||.|||||..|||..   |
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

QTGRTeeLSVFDIVANLRRQRVAMVQTKEQYTLVYKAVE
.....  ..|..|| .||.||  |||. |||  .|||. 
eaeee..vdvlqivkelRkqRpgmvqsleqYiflykail

0045098 (Phosphotyrosine protein) phosphatases II 46-290 8.7e-78 256.8 In-house 26-273 (278) alignment
Range on Protein: 46-290
Range on HMM: 26-273/278.0
NHGEKEYNRTKNRYKDILPYDYSRIVlpeikgvdgsDYINGNYIKGPtkNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPEs
... .. |. |||||||||||.||..          |||| .||.|.  .  ..|.|||||.||.|||||. ...|.|.||.....|||. || .|||| 
tpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe.

mEETLTFAGMKISLESEEAMgDGFTVRTLAVQ------AGKTKHNVTQFHYTAWPDHDVPRSA--TPLIELTRSFRTFVG-------------SQDTPVL
 ...||. .... |.||| . | .|.||| |.      .. ....||..||. ||||.|| .   ....||..  | ..              ....|||
.ggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvl

VHCSAGCGRTGTICALDYARTLLqtgrTEELSVFDIVANLRRQRVA-MVQTKEQYTLVYKAVEELVN
||||||.|||||..|... ..||     . ......|. ||.||   .||..|||  .|... ||..
VHCsaGvgRtGtlvaaylmlell....eggvdlleavkelrsqRpglavqnleqyrflyefllelll

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 13-290 9.3e-78 256.5 In-house 19-284 (319) alignment
Range on Protein: 13-290
Range on HMM: 19-284/319.0
PrnnpQGENGFAKEFQELKNISSRqkrdkafSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDF
     .||....|||..||. ..        .... .|| |..||||..||.|| .|.||.|..||.|||||| ..| |  ..  ..|.|.|| .|..||
s....tgetllekefkllkeavnd.......tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedf

WRMMISHNIQVVVMACREYELGKLKCKRYWPESMeeTLTFAGMKISLESEEAMgDGFTVRTLAVQAGKTKH---NVTQFHYTAWPDHDVPRSATPLIELT
|||.  ... .||| ..  | .|.|.|.||||      ..  . . ||.|| . ... .| | ..  ...    .|..|.||.|||||||..|| |..| 
WrmvWeeessivvmltklveklkvklkkywpeen..feeyGrlivtleeeeel.edyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldll

RSFRTFVGS-QDTPVLVHCSAGCGRTGTICALDYarTLLQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVN
.  |  .   |. |. |||||| ||||| ..||   .| .  . . | || .| .|| ||  |||..|||...|.|. | |.
krirksrektqsgPivvhCsaGvGRtGtfivlda..mlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleave

0040439 (Phosphotyrosine protein) phosphatases II 45-290 2.9e-77 254.9 In-house 3-247 (249) alignment
Range on Protein: 45-290
Range on HMM: 3-247/249.0
TNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPE
....... |. ||||.||||||.||..|  ..|. .||||| .||.|.  .  ..|.|||||.||.|||||.  ..|.|.||.... |||. || .|||.
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

smEETLTFAGMKISLESEEAmGDGFTVRTLAVQ--AGKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGS--QDTPVLVHCSAGCGRTGTICAL
  ...|.. .... | |.|   |..||||| ..    .... |....|| ||||.|| |  .|... .  |... .  ...|||||||||.|||||..|.
..ggsleygdftvtllsvev.kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

DYARTLLQtgRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVN
... ..|.  .. .......|. ||.||  .||. |||  .|.|. ||..
ylmleqle..kelgvdleeavkllrsqRpgavqnpeqyrflyeallelll

subfamily_PTPN6_pd Subfamily PTPN6 6-293 9.8e-77 252.9 In-house 11-301 (306) alignment
Range on Protein: 6-293
Range on HMM: 11-301/306.0
QHKSSLEPRNNPQGENGFAKEFQELKNISsrqkRDKAFSTNHGEKEYNRTKNRYKDILPYDYSRIVLPeIKGVDGSDYINGNYIK--GPTKNIMYLAAQG
|. | ||  ..  . .|| .||.||..        | .| ..|.|  |..||||| |||.| .|..|   ..| ||||||.||||   ....  |.|.||
qrvselekeeeslekagfeeefeelqqee....akkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqg

PLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESMEETLtFAGMKISLESEeAMGDGFTVRTLAVQ---AGKTKHNVTQFHYTAWPDHDVPR
 |..|| |||||.   | .|.||. .|.| || || ||||.. |..  .  ....  ||    . ...|.| |.    .|....| |.|...||||.||.
clettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvse.ksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpk

SATPLI----ELTRSFRTFVGSQDTPVLVHCSAGCGRTGTICALDYART-LLQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVNEEL
.   ..    ...|  ...  ..  |..|||||| |||||.  .|     . ..|   .. . ..|  .|.||  .|||..|| .||||... .... 
dpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkk

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 16-293 1.7e-75 248.8 In-house 16-283 (288) alignment
Range on Protein: 16-293
Range on HMM: 16-283/288.0
NPQGENGFAKEFQELKNISSRQkrdkafSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRM
. ....|| .|.. | .. . .      |.. |..  | .||||..|||||. |. | . . ..|.|||| .||.|  |.  |.|.||||..||.|||..
sarnrtgfseeynsLaalektk......svtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWel

MISHNIQVVVMACREYELGKLKCKRYWPESMEeTLTFAGMKISLESEEAMGDgFTVRTLAVQAGKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTF
.  .... .||     | || ||..|||.. .    .  ... | ... ..| |..|.| ..  ||. ..||..|.|||||.||.|..||.|| |   . 
vyenktstivmltelveggktkCeeYWPdadk.pknyGsvtvtlveskeled.fvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkva

VGSQDTPVLVHCSAGCGRTGTICALDYARTLLQTgrTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVNEEL
  ..  |..|||||| |||||  ||| .   ...  .. . |...||.||.||  .|||..||  .|... .|..|. 
nqadtgpiivhCsaGvGrtgtFialdalidavee..edyiDvagtvaklRkqRallvqtlkqYefiyevllslieedg

0042113 (Phosphotyrosine protein) phosphatases II 46-289 2.5e-75 248.3 In-house 2-243 (245) alignment
Range on Protein: 46-289
Range on HMM: 2-243/245.0
NHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPEs
...... |..||||.||||||..|..|....|  .||||| .|..|.  .  ..|.|||||.||.|||||. ...|...|| ..| |||. || .|||. 
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.

mEETLTFAGMKISLESEEAmGDGFTVRTLAVQ--AGKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVG-SQDTPVLVHCSAGCGRTGTICALDY
 .|.||. .... | |||   |..||||| |.    . ...|...||. ||||.|| .   |... .  |...  ....|||||||||.|||||..|...
.gesltygdftvtllseeh.lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaayl

ARTLLQTGrtEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELV
. ..|..    ..|....|. ||.||  .||| .||  .|.|. ||.
mleqleke..lgvsleeavkelrsqRpgavqtpsqyrflyeallell

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 11-289 8.8e-75 246.7 In-house 17-290 (298) alignment
Range on Protein: 11-289
Range on HMM: 17-290/298.0
LEPRNNPQGENGFAKEFQELKNISSrqkRDKAFSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVD
|.  .. ..  |.|.|||.|...||   . ...... ..|..|. |||| ||...|.||.|| .... . |||||  .... ...  ..|.|.||..|| 
laavkkkkkltgyalefqrlnsvss...eieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetve

DFWRMMISHNIQVVVMACREYELGKLKCKRYWPESMEEtlTFAGMKISLESEEAMGDgFTVRTLAVQAGK--TKHNVTQFHYTAWPDHDVPRSATPLIEL
|||||.. ..|...||     ||.|.|...|||.. .|  |.  ...|| |.| ..| ..||.|.|.  |  ....| |.|.| |||..||. || ...|
dFWrmvteedigtiVmltnleeldktkyhkywPdegke..tygeitvsllskeefad.livrklkvskkkeekerevrqlhftsWpdkgvpenatsvldl

TRSFRTFVG-SQDTPVLVHCSAGCGRTGTICALDyaRTLLQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELV
 |  |.    . ..||.|.|||| ||.|| .|.|    | .  . . . ||..|  ||..|...|||.|||. .|.|| | .
lrkvrasqqqagnkpvivqCsaGvgRsGtfiaid..svlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleal

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 16-293 3.4e-74 244.5 In-house 10-280 (281) alignment
Range on Protein: 16-293
Range on HMM: 10-280/281.0
NPQGENGFAKEFQELKNISSRQKRDKAfstnhgEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRM
. . ..||..|...|..|  ..    .      ... |..||||..|  || .|... . .    .|||| |...| ...  |.|.|||.|.....||.|
sqndnaGfieeyeklaaigvdntatas......kadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqm

MISHNIQVVVMACREYELGKLKCKRYWPESMEeTLTFAGMKISLESEEAMgDGFTVRTLAV-QAGKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRT
.........||  || | ||||| ||||.  . .|... .... ..||.    .  |.. . . .  . .|.|..||||||| || ... |.|  .  . 
vweqkvsaivmvtreieagklkChrYWPddns.elkygdvtvkstaeeek.atyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlk

FVGSQD-TPVLVHCSAGCGRTGTICALDYARTLLQtGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVNEEL
.  ..  .|...||||| |||||  ||| .   ..  ..|||.| ..||.||..|  ||||  ||. ||||| . ...||
ltekktkaplvihCsaGvGrtGtyialDrlvkave.aeleeldvkavvaelrkernlmvqtvvqyefvykavldaldkel

0037934 (Phosphotyrosine protein) phosphatases II 46-288 7.8e-74 243.6 In-house 3-241 (243) alignment
Range on Protein: 46-288
Range on HMM: 3-241/243.0
NHGEKEYNRTKNRYKDILPYDYSRIVLpeikgvDGSDYINGNYIKGPtKNimYLAAQGPLPKTVDD----FWRMMISHNIQVVVMACREYELGKLKCKRY
... ...|..||||.||||||.||..|      .||||||.|.|... ..  . | |||||.||.|    ||||. ...|.|.|| ....|||..|| .|
siallpenlsknrysdilpydhsrvkl......egsdyinanliyvt.pr..liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

WPesmEETlTFAGMKISLESEEAMGDgFTVRTLAVQA---GKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTF--------VGSQDTPVLVHCSAG
||   .|. |. .... | ||| ..| .||||| ..    .. ...|...||..||||.|| | ..|... .  |.|        . ... |||||||||
wp...gev.tygdftvtllseehldd.ytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaG

CGRTGTICALDYARTLLqtgrteELSVFDIVANLRRQRVA-MVQTKEQYTLVYKAVEEL
.|||||..|...  .||      .......|. ||.||   .||| .||  .|.|. ||
vgRtGtliaaylmllll......gvdleeavkllreqRpgkavqtpsqyrflyeallel

subfamily_PTPN13_pd Subfamily PTPN13 24-289 4.1e-73 241.0 In-house 14-269 (273) alignment
Range on Protein: 24-289
Range on HMM: 14-269/273.0
AKEFQELKNISSRQKrdkafsTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGvdgsdYINGNYIKGPT--KNIMYLAAQGPLPKTVDDFWRMMISHNI
|.||.||... . ..      .. |.|. |..||||...|||| .|. | .  |     ||| ..|| |   ..  |.|.|||||.||.|||.|.   . 
aeefkelrelkpldt......cevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqka

QVVVMACREYELGKLKCKRYWPESMEETLTFAG-MKISLESEEAMgDGFTVRTLAVQAGKT--KHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGs
.|..|   | | ||.||.||||||....|.  . ....|.  . . |||.||.|||.  ..   ..|.......||||.||.||..|... .  |..   
eviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkl.dgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.

QDTPVLVHCSAGCGRTGTICALDYARTLLQtgRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELV
. .|..|||||| ||.||. ..| .  |..  | .|. | .|| .||.|| ..||||.|| .||||. |..
dagPivvhcsaGiGrsGtlitidvvlglie..rdkefdvkeivrklreqrqgvvqtkdqyifvykailevl

subfamily_PTPRG_pd Subfamily PTPRG 17-291 1.4e-71 236.5 In-house 15-289 (563) alignment
Range on Protein: 17-291
Range on HMM: 15-289/563.0
PQGENGFAKEFQELKNissrQKRDKAFSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGS-DYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRM
 .|. ||..||..|..    .  .| . ..| .|. |. |||| .|..|| ||. | .. |.... |||| |||.|  |.  ..|.||||..|.||||||
adgdigfseefealqs....etiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrm

MISHNIQVVVMACREYELGKLKCKRYWPEsmEETLTFAGMKISLESEEAMGDgFTVRTLAVQA-----GK---TKHNVTQFHYTAWPDHDVPRSATPLIE
.  .| ...||     | |. ||..|||.  .|..|.  ... |..|| .    ||||| ..      .|   |...|.|.||| ||||.|| ...| . 
iWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlal.ytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLi

LTRSFRTFVGSQDTPVLVHCSAGCGRTGTICALDYARTllQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVNE
  .   .   ..  |..|||||| ||||| ..||      |  . .   ||...  .| ||  .|||.|||. ...|. |... 
fvkkssaankaeaGPivvHcsaGvgrtGtyivldtllk..qiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias

subfamily_Ptp69D_pd Subfamily Ptp69D 17-288 2.4e-71 235.4 In-house 18-285 (307) alignment
Range on Protein: 17-288
Range on HMM: 18-285/307.0
PQGENGFAKEFQELKNIssrqkrDKAFSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMM
 . . |.|||...|..           ||. .||. |  ||||.|| ..|  |..|..|.| . ||||| ..|||  ..  ..|||.|.  |..|||||.
rdtdfglakeyekLear......eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmi

ISHNIQVVVMACREYELGKLKCKRYWPESmeETLTFAGMKISLESEEAMGDgFTVRTLAVQAGK-------TKHNVTQFHYTAWPDHDVPRSATPLIELT
   .....||   . |  . ||..|||.   ..  .  . . | ||| ..| .. |.| |   |        ...|.|.|||.|.|  ||..|. |..| 
aeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsd.yiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllkli

RSFRTFVGSQDTPVLVHCSAGCGRTGTICALDYartLLQT-GRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEEL
.  |     . .|..|||||| ||.|.. |||    |||     .....|..| .||.||  .||  |||. .|.|. . 
eqvrelyklnrsPivvhCsaGvgrsgifvalds...llqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldy

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 44-290 7.1e-71 233.8 In-house 37-284 (305) alignment
Range on Protein: 44-290
Range on HMM: 37-284/305.0
STNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWP
|.. |.|| |..|||.|.| ..| .|| | | . .| ||||| .|..|  ..  |..|||||..||.||||...   ....|| ..  | || ||..|||
sidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWp

ESMEETLTFAGMKISLESEEAMGDgFTVRTLAVQA---GKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFR-TFVGSQDTPVLVHCSAGCGRTGTICA
||. |.  |  ... |.||... | .. | | .      | ...|.|.. | |||| ||..|| |..| .  . .   ....|.||||||| ||||. .|
esktekkefgefsvelksektasd.yieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfia

LDYArtLLQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVN
.| |  | .  . |.. ||... .||..|. ||||..||. .. |..||..
vdia..lerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelit

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 42-302 3.2e-70 231.4 In-house 33-286 (315) alignment
Range on Protein: 42-302
Range on HMM: 33-286/315.0
AFSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRY
.. .. . .. | .|||||.|||.| .|..|  |     |||||  |||.  ..  |.|.||||. .|||||||.. ...  .||     |  |.||..|
iyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqy

WPESMEETLTFAGMKISLESEEAMGDGfTVRTLAVQAGKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGSQDTPVLVHCSAGCGRTGTICALD
||.   ..  |  .|..| | || .|| ..| | .. ......||||..| |||. |.. .. |..| .  ..  |... ..||||||| |||| ....|
wPdrkadsvefGsikvellsleadtdg.varklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisid

yaRTLLQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEElvneELRKQNHLYVN
    . |  ||. . ||..| |||..|. .|||.|.|...| || |    .|  .| | . 
..evvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavle....dllwrntlilv

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 48-290 1.9e-69 229.1 In-house 38-277 (515) alignment
Range on Protein: 48-290
Range on HMM: 38-277/515.0
GEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESME
 ..| | .|||||.||||| .|. |  |.    |||.|  ||..   .  |.|.|||.. .||||||... .|.  ..|  .  |  | || .|||.   
aqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpg

ETLTFAGMKISLESEEAMGDGfTVRTLAVQAGKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGSQDTPVLVHCSAGCGRTGTICALDYArtLL
... |  .|..| | || ..| . |.| |  |.  . |||||.| |||. ||. .. |. | .  ..  |    |...||||| |||| ....|    . 
dsvkfGsikvelvsleactgg.ikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsv..va

QTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVN
.   |. . ||..| |.|..|. .|||.|||...| || | . 
hakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll

subfamily_PTPRA_pd Subfamily PTPRA 45-288 3.5e-69 228.2 In-house 50-294 (330) alignment
Range on Protein: 45-288
Range on HMM: 50-294/330.0
TNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPE
 .  .|| |. |||. .|||||.||..|....||. |||||  .|.|  .   ..|||||. .||.|||||.  .. . .||     |  . ||..|||.
lelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPd

smEETLTFAGMKISLESEEAMGDgFTVRTLAVQ------AGKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGSQDTPVLVHCSAGCGRTGTIC
  | ..|.  .....| |. . | .||| . ||        |..  |.|||.|.|||  ||  .  ...| .  ..    .  |. |||||| ||||| .
..eGlvtyGnirvevedetvlvd.ytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfi

ALDYARTLLQTGRteELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEEL
.||     ... |   . ||..| .|| ||  ||||.|||...||.. | 
vldavlervkaer..kvdvfefvkrlrlqrpqmvqtdeqyefiykvlley

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 49-291 3.8e-69 227.7 In-house 16-266 (270) alignment
Range on Protein: 49-291
Range on HMM: 16-266/270.0
EKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKN-IMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESME
|   ... |||.||||   .|..|.|..  . . ||| ||..| ...   |.||.|||| |. .||||..... . .||.    | |. ||.||||.. .
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk

ETLTFAGMKISLESE-EAMGDGFTVRTLAVQAGKTKHNVTQFHYTAWPDHDVPRSAT------PLIELTRSFRTFVGSQD--TPVLVHCSAGCGRTGTIC
|..... .||.  .. |.  .|. .. | ..   ...... |.|..|||| |||..        |... |  | .  ..|  .|.||||||| |||||. 
ekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtli

ALDYARTLLQTgrTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVNE
|||.|  ||..  |... |  |...||..|.|.||. |||...|||| | .. 
alDiavrlLee..tkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 48-301 1.3e-67 223.0 In-house 44-292 (315) alignment
Range on Protein: 48-301
Range on HMM: 44-292/315.0
GEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESme
  |  |. |||| .|..|| ||. || ..  ..|||.| |.|.| .|. .|.|||||.. .|.||||..  ..|  .||     |  | |...|||.   
akkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk..

eTLTFAGMKISLESEEAMgDGFTVRTLAVQAGKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGSQDTPVLVHCSAGCGRTGTICALDyaRTLL
  ...  . ... |||   . .|||||.|  |.  ..| |.|||.||| .||....||..| |  . .  .. ....|||||| ||||| ..||    | 
.kviyGkitvtrkseevn.teytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitld..avld

QTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAV-EELVNEELRKQNHLYV
|    . . |.... ..|..|. |||. ||| ..|.|. | .|  .    ..||.
qaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlyl

subfamily_PTPN3_pd Subfamily PTPN3 38-289 2e-67 222.1 In-house 26-275 (280) alignment
Range on Protein: 38-289
Range on HMM: 26-275/280.0
KRDKAFSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKgvdGsDYINGNYIK--GPTKNIM--YLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYEL
....  ....  |  | .||||.||||||  |. | | .     |||| ||..   |.....  |.|.||||.||. |||.|.  ......||     | 
rkkpglaisaarkpenlsknryrdilpydatrvklkese...t.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlver

GKLKCKRYWPEsMEETLTFAGMKISLESEeAMGDGFTVRTLAVQAGK--TKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGSQDTPVLVHCSAGC
|. ||..|||| .|..|....... .|.| .    . .| | ..  .   .....|. |.|||||.|| ... ..|.... |.   ....||.|||||| 
GrvkChqyWPe.tedeleygefsvkceke.detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGi

GRTGTICALDYARTLLQtgRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELV
|||| . .|. | .|..  ..|.. . ||| ..| || ..|||..||..| .|. .. 
grtGvlilletalalie..aaepvypldivrtmrdqramlvqtasqykfvCeailkvy

subfamily_PTPN9_pd Subfamily PTPN9 16-289 3.5e-67 221.5 In-house 11-290 (297) alignment
Range on Protein: 16-289
Range on HMM: 11-290/297.0
NPQGENGFAKEFQELKNISSRQKrdkafsTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRM
. .|..|  ||..|..| .   .       .. ..  | .||||.|.| || .|.||..... . ||||| |.. |  ..  ..|.||||.|||.|||||
kekgkrGlskeyaeirnepveGt......flasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrm

MISHNIQVVVMACREYELGKLKCKRYWPESMEETLTFAGMKISLESEEAMGDgFTVRTLAVQAGK--TKHNVTQFHYTAWPDHDVPRSATPLIELTRSFR
.  ... |.||. |  | |.|||..|||.. |..  |. ...|  . | . | ..||.| ..  |   . .|| | ...|||. ||.||. |... .  |
vWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeed.ykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvr

TFV-------G------SQDTPVLVHCSAGCGRTGTICALDYARTLLQTgrTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELV
          |       .. |..|||||| ||||| ..||.. . |..  .. . |.. |  || ||  ..|| |||.. |.|| |  
ekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrlee..vgtvdvvetvkllrtqrafsiqtpeqyefcylavleya

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 43-294 5.3e-66 217.7 In-house 41-290 (297) alignment
Range on Protein: 43-294
Range on HMM: 41-290/297.0
FSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKniMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKlKCKRYW
...   ||  |  |.|||.||||| ||. |  .     |||.|  ..||  .   ... | | . ||.|||.|.. ......||   . |  | ||.|||
qpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryW

PESMEETltFAGMKISLESEEAMgDGFTVRTLAVQAGK--TKHNVTQFHYTAWPDHDVPR--SATPLIELTRSFRTFV-GSQDTPVLVHCSAGCGRTGTI
...   |  |  . . |.| .    ||  |.| |. ||  ... | |.... |||..|.|  ||. |..|    |    . ...|.||||.|| |||| .
sdkgvtt..fGdvsvvllsvser.eGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvl

CALDyaRTLLQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEE-LVNEELR
...|    . .  |..|. .|..|  ||..|. .|||||||..||.|| | |. |. |
ltid..svvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtr

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 52-287 2.2e-65 215.5 In-house 27-266 (274) alignment
Range on Protein: 52-287
Range on HMM: 27-266/274.0
YNRTKNRYKDILPYDYSRIVLPEIKG-VDGSDYINGNYIKGPTKN-IMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESMEE-
 . ||||||.||| . ||..| . ..  . |.||| |||||. ..  .|.|.|||||.||.|||||.  ...||.||  .  |  . ||..|.|.. .  
gsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedye

-TLTFAGMKISLESEeAMGDGFTVRTLAVQAGKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGSQD---TPVLVHCSAGCGRTGTICALDYAR
 . .. ...|  |.     ....||.| ..  . ...|. . ||.||||..|..|..|..| .  ..   ...   .||.|||||| ||||   | . | 
iserygdveikveki.verndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiav

TLLQtgRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEE
  |.  ... . |. ||.||| .|  ||||.||| |...|. .
rqlr..eeivvdvlkivcnlrldrGGmvqtseqyelihralcl

subfamily_PTPRK_pd Subfamily PTPRK 46-288 3.8e-64 211.5 In-house 36-278 (314) alignment
Range on Protein: 46-288
Range on HMM: 36-278/314.0
NHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPES
.   |. ||.|||..|||.|| ||..|  |.|   |||||...| . ..   ....||||..|| ||||..  .|   .||     | |..|| .|||| 
daakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed

MEEtltFAGMKISLESEEAMGDgFTVRTLAVQA----GKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGSQDTPVLVHCSAGCGRTGTICALD
 |    .  .|. | . |.  . . ||...|.      . .. | ||....||||||| ||| |..| |   .    .. ...||||||.||||| .|.|
tev...ygdikvelvetellae.lvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaid

YARTLLQtgRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEE--L
    ...  | . . || .| .|| ..| ||.|.|||...| .. |  |
ivldmie..regvvdvfnavktlrsrkvnmveteeqykfiydvileacl

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 46-289 6.1e-64 210.6 In-house 2-242 (250) alignment
Range on Protein: 46-289
Range on HMM: 2-242/250.0
NHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLkCKRYWPes
. ..|  |. |||| ||...| ||.|| . || . |||||  ...| ... ...|.||||..|. |||||.. ......||     | .|  ...|||  
svakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP..

MEETLTFAGMKISLESEEAMGDgFTVRTLAVQAGKTKHN--VTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGS-QDTPVLVHCSAGCGRTGTICALDY
.|.. .. ....|| |.| ..| .|.|.| .   | ...  | |.|...|||  ||. ||  .|| .  ..     ...||.|.|||| ||.|. .|.| 
vekaekyGdvtvsllskeefad.ytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaida

arTLLQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELV
   | .  . . . ||...  ||..|. .|...|||  ||... . .
..vlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkal

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 15-290 1.1e-60 200.0 In-house 14-284 (290) alignment
Range on Protein: 15-290
Range on HMM: 14-284/290.0
NNPQGENGFAKEFQELKNISSrqkrdkAFSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGV-D-GSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDF
.. .|..|| ..|. |.. .|       .....|  . |...||...|..||  ||.| .| |  |   .|||  ||||  ..  |.|.|||...|. ||
ghakgnegfrnqfkmldsges......ehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdF

WRMMISHNIQVVVMACREYELGKLKCKRYWPESmE-ETltFAGMKISLESEEAMGdGFTVRTLAVQAGKT---KHNVTQFHYTAWPDHD-VPRSATPLIE
|...  ... ..|| . . | || ||. |||.| . ..  .  ..| | .||..  ... |.| |.  ..   |..|||.. |.|.... |.  .| |. 
WkliwqekvtiivmltniieegkvkCqqYWpds.dtka..ygefsikllneetln.eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillv

LTRSFRTFVGSQDTPVLVHCSAGCGRTGTICALdyARTLLQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVN
...  .|   . .|...||||.. ||... ||.  | |. ..  .    ||... ..| |.  .|||..|| .... | . ..
ieemyktqrkrgntsivvHCSdtvgrsavfcaa..attinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 16-290 1.6e-60 199.5 In-house 15-279 (287) alignment
Range on Protein: 16-290
Range on HMM: 15-279/287.0
NPQGENGFAKEFQELKNISSRQKrdkafSTNHGEKEYNRTKNRYKDILPYDYSRIVLPeikgVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRM
. .|..|| . |. |.... |..     .  |.  . |. |||...||..|  |..|         ||||  .|.|  ..  ...|..|. .|. .||..
hakgnegfknqftvleqvtqred.....evthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkl

MISHNIQVVVMACREYELGKLKCKRYWPESMEetLTFAGMKISLESEEaMGDGFTVRTLAVQAGK---TKHNVTQFHYTAWPDHD-VPRSATPLIELTRS
.  .|....|| |.| |  . .| .||||.    ...   .|.| .|| . .|...|.| |.  .   .|..|.|...|.|...  |.. .| |. . . 
iddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellnee.vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieem

FRTFVGSQDTPVLVHCSAGCGRTGTICALDyaRTLLQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVN
..|   . .|...||||.. ||... || .   |. .. .   . ||... . | |.  .||| |||. ....| | ..
yktqrkrgntsivvhCsdtvGrsamfcaaa..ttinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyld

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 42-287 3.5e-59 195.7 In-house 50-289 (319) alignment
Range on Protein: 42-287
Range on HMM: 50-289/319.0
AFSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACreyelgKLKCKRY
    .. . . |. |||. .||..| ... |  . |...|||||  ...|  .. .|.||||||. |..|||||.  .|.  .|.        | || .|
ladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqy

WPESMEETLTFAGMKISLESEEAMgdgFTVRTLAVQA-GKT--KHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVG--SQDTPVLVHCSAGCGRTGT
||  ....     .|...  | |    ..|| . .   ||   . ..||||.  |||. || ....|. | .  | .     . ....||||||.||||.
wplkivikeerfkvkvdsveetae...yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGv

ICALDYARTLLQtgRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEE
  .||     ..  . . . |...| .||.||  .||   || ..| |. |
yivldvlldrmk..eekqvdvynfvrdlrqqrntlvqdlvqykfiysalle

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 16-289 7.6e-59 194.4 In-house 18-288 (325) alignment
Range on Protein: 16-289
Range on HMM: 18-288/325.0
NPQGENGFAKEFQELKNISSRqkrdkAFstNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRM
. | ..|||.||. | .  .      |.  .   |  |. |||.|.....| ||.||   |    ||||| .|..   |  ..|||| ||..|..|.||.
kaqdqdgfahefgllpsddgi.....ak..kvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrl

MISHNIQVVVMaCREYELGKLKCKRYWPESMEETLTFAGMKISLESEEAMGDgFTVRTLAVQAGKTK--HNVTQFHYTAWPDHDVPRSATPLIELTRSFR
..  .  |||.   | .||| .|  |||. | .. || |....| . | . | .  | | |.  |      | ||.. .|.|  |..  . || ...   
vldWrcsvvvv.lneldlgkdrcavywpkemgksktfGglevklrtieeisd.yvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvk

T---FVGS---QDTPVLVHCSAGCGRTGTICALDYArtLLQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELV
.    | .     ||.||||||| ||||.  .|  |  | .     .. .|. | .||..| .||.| .||.|.|.|. | .
avservtantkastpilvhcsaGvGrtGvfislysa..lakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay

subfamily_PTPN23_pd Subfamily PTPN23 14-295 9.6e-59 193.5 In-house 8-286 (288) alignment
Range on Protein: 14-295
Range on HMM: 8-286/288.0
RNNPQGENGFAKEFQELKNISSRQKRDKAFSTNhgekEYNRTKNRYKDILPYDYSRIVLPeikgVDGSDYINGNYIKGPTKN-IMYLAAQGPLPKTVDDF
|. ..|. .. |.|.||..   .. |... .      . . .|||..|||||| .|..|         ||||  ..|. .     ..|.|.||..|. ||
rkmldgktaldkkfkeleqkqdkearkrsiaia....klyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDF

WRMMISHNIQVVVMACREYELGKLKCKRYWPESMEETLTFAGMKISLESEEAMgDGFTVRTLAVQAGKT--KHNVTQFHYTAWPDHDVPRSATPLIELTR
|.|. .   .|.||   . |||| |..|||||. .|| .|  ....|.|.. . . .  |.| ..  ..  ...|.  ..|.||.. || |   |...  
WlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvret.ethvervlkletldadavksvshlqltsWpelGvPasPetllqfld

SFRT----FVGSQDTPVLVHCSAGCGRTGTICALDYARTLLqTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVNEELRK
  ..         .||..|||||| ||||... .  | . | . .   | . ..|  ||.||  |||.|||.  .|.|| | ... | |
evesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrel.ekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvldk

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 44-287 2e-58 193.1 In-house 16-253 (284) alignment
Range on Protein: 44-287
Range on HMM: 16-253/284.0
STNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACreyelgKLKCKRYWP
  .. . . |. |||. .||..| ... |  . |...|||||  .|.|  .. .|.|.||||. |..|||||.  .|.  .|.        | || .|||
dqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywp

ESMEETLTFAGMKISLESEEAMgdgFTVRTLAVQA-GKT--KHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVG--SQDTPVLVHCSAGCGRTGTIC
  ....     .|... .| .    ..|| . .   ||   . ...|||.  |||. || ....|. | .  | .     . ....||||||.||||.  
lkivikeerfkvkvdsveesee...yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyi

ALDYARTLLQtgRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEE
.||     ..  . . . |...| .||.||  .||   || ..| |. |
vldvlldrmk..eekqvdvynfvrdlrqqrntlvqdlvqykfiysalle

subfamily_PTPN1_pd Subfamily PTPN1 37-287 5.6e-57 187.7 In-house 16-269 (290) alignment
Range on Protein: 37-287
Range on HMM: 16-269/290.0
QKRDKAFSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGvdgsDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKL
.|  . |.|.. ... ||..|||.|. |||.|||.| . .     |||| . .. .  .  |. .|||||.||| ||.|.  .. . |||  .  | ...
rkeasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqi

KCKRYWPESME-ETLTFA--GMKISLESEEAMgDGFTVRTLAVQAGKTK--HNVTQFHYTAWPDHDVPRSATPLIELTRSFRT--FVGSQDTPVLVHCSA
|| .|||.  | ..|..    .|. | |||   . .|||.| ..  ||.  .....||||.|||  ||.| . ....    |    . |.  |...||||
kcaqywPqgeeekellledtklkvkliseerk.syytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsa

GCGRTGTICALDYARTLLQTG-RTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEE
| ||.||.| .|    |..    .. . . . . .||..|. ..||..|  . | |. |
GiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile

subfamily_PTPRN_pd Subfamily PTPRN 40-292 8.6e-57 187.1 In-house 43-295 (297) alignment
Range on Protein: 40-292
Range on HMM: 43-295/297.0
DKAFSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKG-PTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKC
 .  ... ...| | .|||.|..|||| ||. | |    . |||||   |     .. .|.|.||||..|| |||.|.  . . |.|. .|  | |  .|
aepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqc

KRYWPESMEETltFAGMKISLESEEAMGDGFTVRTLAVQAGKTK--HNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGSQDTPVLVHCSAGCGRTGT
|||||.  .|.  .   .. | ||    | . ||.. ..  .|.    |||||. .||...|| || .|.|. |        . .|..||||.|.||||.
krywpdeGsev..yhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGv

ICALDYARTLLQTGrTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVNEE
 ...|   . |. |   |. .   .  || ||  .|.||.|. ....|| | ||. 
yilidlvlnrllkG.vkeidiaatlehlrdqrpglvktkdqfefaltavaeevnai

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 21-286 8.9e-56 183.8 In-house 10-274 (287) alignment
Range on Protein: 21-286
Range on HMM: 10-274/287.0
NGFAKEFQELKNISsrqkRDKAFSTNHGEKEYNRTKNRYKDILPYDYSRIVLPeIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHN
.   ||.. ||. |    .  ..     |. ..  |||| |.||.| .|..|   .|  |||||| ||. . |..  ..|||||.. || ||||... ..
ddvdkevdalkeds....esstatfkaaeelaavkknryadvlPiddtrvlls.aegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletr

IQVVVMACREYELGKLKCKRYWPESmEETLTFAGMKISLESEEAMGDGFTVRTLAVQAGKTK--HNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFV--
  .|..  || | ..||| .||||  |  .   |  . | . . .   ..||.| .   .|.  . | |... .|||. .. .|  || .. . . ..  
sasvitmtreveearlkcykywPer.evPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhiel

---GSQDTPVLVHCSAGCGRTGTICAL-DYARTLLQTGRTEelsVFDIVANLRRQRVAMVQTKEQYTLVYKAVE
   .|.  |..||...| ||.|.. |.    . |...|| .   |  .|. || .| |.||.  |. |.|.|. 
ardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvd...vaavvirlreyraalvqavvqlrllyealv

0041856 (Phosphotyrosine protein) phosphatases II 53-289 1.6e-52 173.0 In-house 1-171 (182) alignment
Range on Protein: 53-289
Range on HMM: 1-171/182.0
NRTKNRYKDILPYDYSRivlpeikgvdGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACreyelgklkCKRYWPESMeetltf
|..||||.||||||.||          ..|||| |.. |. ..  ..|.||||..|| ||.||. ...|...|...         . .||||        
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell......

agmkisleseeamgdgftvrtlavqagktKHNVTQFHYTAWPDHDVPRsatplIELTRSFRTFVGSQDTPVLVHCSAGCGRTGTICALDYARTLlqtgrt
                             .....|..|. ||||.||      .. . .|   | ... |||||||||.|||||..|... ..|      
.............................erlgiqylylpwpDhgvpd.....ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl......

eELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELV
 ..|....|. .|..|  ||.| .|| ... |. ||.
.gvsleeavklvrsrRpgmvitpnqyfflqlallell

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 23-287 1.8e-52 173.3 In-house 22-277 (439) alignment
Range on Protein: 23-287
Range on HMM: 22-277/439.0
FAKEFQELKNISsrqkRDKAFSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQ
| ..|.... .|     | |  ..   .||..|||||||. ..|..|..| || ||  | ||| |||||  .. .|.|.|||  .|.|||||..| ..  
fkeifekinsts....pdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktv

VVVMACREYELGKlkckrYWPESMEETLTFAGMKI--SLESEEAMGDGFTVRTLaVQAGKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGSQD
 .|| .   |  |     ||| . |       ...   .|  . .  || |     . .. .. | ||||.||||..||  |. .... |.  .   ...
tivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfne.rdttekertvlqfhyiawpdknvpaqashvldflrainsandkee

-TPVLVHCSAGCGRTGTICALDYARTLLQtgRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEE
  ||.|||||| |||||| ||| |   |.    ... .  ||  ||.||  |||.  || ..|.|| |
ygpvvvhcsagvGrtGtiialdialeqlk..lenkvdikgivkvlrkqrkqmvqalcqyvfiynavle

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 41-287 1.9e-52 173.0 In-house 33-234 (392) alignment
Range on Protein: 41-287
Range on HMM: 33-234/392.0
KAFSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGklkckr
... .. ..|| |  |||||.||||| .|..|  |  .  |||.|  ||..   .  |.|.||| . ..||||||.  .|.  ..|  .  |        
diypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd......

ywpesmeetltfagmkisleseeamgdgftvrtlavqAGKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGSQDTPVLVHCSAGCGRTGTICAL
                                      |. .. |.|||.| |||.|||. .. |... .  ..  |.   |...||||| |||| . ..
.....................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisi

DYARTllQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEE
|   .  .. .|  . ||..|.|.||.|  ||||||||...| || |
dsvva..hakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle

subfamily_PTPN14_pd Subfamily PTPN14 26-289 3.2e-52 172.4 In-house 25-296 (300) alignment
Range on Protein: 26-289
Range on HMM: 25-296/300.0
EFQELKNISSRQKrDKAFSTnhGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVdGSDYINGNYIKGP--TKNIMYLAAQGPLPKTVDDFWRMMISHNIQV
 |.|  .|. ... |  .||  .. . |  |||.||.|||. .|. |   |    ..|||   || .  .|.  |..|||||..|| |||.|.  ...|.
vfteyeripkkre.dallst..aklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvql

VVMACREYELGKLKCKRYWPES--MEETLTFAGMKISLESEEAMGDgFTVRTLAVQ--AGKTKHNVTQFHYTAWPDHDVPRSATPLIELTR---SFRTFV
.||  .| | || |. .|.|..   ..|..|   |.. .  |  .  .. ..| ..    | . .|  . || ||||.||.  .. ..  .   | |  .
ivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsds.vittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrkt

GSQ------DTPVLVHCSAGCGRTGTICALDYARTLLQTGrtEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELV
 |.      . ||||||||| |||| .   |   . |...  ||. .  ..| ||.||  .|||  ||. |||.. . .
nseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehn..eeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl

subfamily_CG7180_pd Subfamily CG7180 44-289 5.3e-51 168.0 In-house 33-290 (296) alignment
Range on Protein: 44-289
Range on HMM: 33-290/296.0
STNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKlKCKRYWP
   .| .. || |||. ...|||| |.||....| . |||||  |. . .|.  |.  ..|  .|||.|||..  ..|. ||. ... .  | ... |||
dCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywp

ESMeeTLTFAGMKISLESEEAMGDgFTVRTLAVQAG------------KTKHNVTQFHYTAWPD-HDVPRSATPLIELTRSFRTFVGSQ-----DTPVLV
. .     .  . . . .|. . . .. ||. ..                .  |..|..| |.  . || |.. |||| |  |....         ||.|
nks..keqygeifveiveekqyan.lkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvv

HCSAGCGRTGTICALDYArtLLQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELV
..| | .|.|  .|.| .  | .  ..||. ||. |  |||.|  .|...|.|  .|  ..| |
vssdGasRsGvylaidan..lelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 49-286 4.9e-50 164.8 In-house 52-280 (290) alignment
Range on Protein: 49-286
Range on HMM: 52-280/290.0
EKEYNRTKNRYKDILPYDYSRIVLPEikGVDGsDYINGNYIKGptKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESMEE
.|. . .||||||.   | .|..| .  | || ||.  ||.||   . |.. .||.| .|| |.|||.. ... ..|| |   | || ||..|.||   |
dkntefkknrykdvvcndktrvilkd..GydG.dyvhanyvkG..lkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGe

TLTFAGMKISLESEEAMGDGFTVRTLAVQAGKT--KHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGsqdtPVLVHCSAGCGRTGTICALDYARTL
.|||  . .    |.   .    .||.|.  ..  .| .  ..  .|||. |. |.  |. . |. |.  |    || |||||| |||||. |.. .  .
vltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrkasG....pvvvhcsaGiGrtGtfvaievglqi

LQTGRteELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVE
|  |.  || . |.|  ||. |.. ||   || .. ... 
lldGk..eldlldlvralrnsrlnsvqvdiqylalveill

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 20-289 1.1e-47 157.2 In-house 14-293 (301) alignment
Range on Protein: 20-289
Range on HMM: 14-293/301.0
ENGFAKEFQELKNISSRQkrdkafsTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVD--GSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMI
.|.|.....|||. ....       .. | .| |.. ||.|.| .||  ||.| . . .|    .||| .||.| ...  . |||||. ||. ||||...
snkfeeqykelkegedks.......ctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliw

SHNIQVVVMACREYELGKLKCKRYWPESMEETLTFAGMKISLESEE----------------AMGDGFTVRTLAVQAGKTKHNVTQFHYTAWPDHDV-PR
 .  . .|| . . |  | ||..|||.| .|. .|  ... | .|                 . ..|.. |...|.. |. ..|.|.. | ||.. | . 
qekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvre

SATPLIELTRSFRTFVGSQDTPVLVHCSAGCGRTGTICALDYArtLLQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELV
 .| |  .     .       ||.||||.. .|.|. |... .  | |  .     ||...  .||..  .|.| |||| .|..... .
prtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsig..lEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmyl

0051429 (Phosphotyrosine protein) phosphatases II 79-291 1.7e-47 157.7 In-house 2-227 (272) alignment
Range on Protein: 79-291
Range on HMM: 2-227/272.0
DGSDYINGNYIKGPtknIM------YLAAQGPLPKTVDDFWRMmISHNIQVVVMACREYELGKLKCKRYWP----------ESMEETLTFAGMKISLESE
. |.||| ....|.           .....|||| |..||||.  ...| ..|. ..|.|.|.||| ||||          .....| ..  . . | ||
plsgyiNardvggy...grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllse

EAMGDgFTVRTLAVQ---AGKTKHNVTQFHYTAWPDHDVPRSAtpLIELTRSFRTfvgsqDTPVLVHCSAGCGRTGTICALDYARtlLQTGRTEELS---
| . | ...|.| .      .. . |...|||.|||| ||..|  |.|| . ...     . |||||||||..||||..||..    |. ...  .    
ellld.yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvalllll..lgvsletivddYl

-----VFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVNE
     ....|. ||.|| ..||| |||  .|.|. ||...
ltnlyleeaveelraqrpgavqteeqylflyeallellrs

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 49-287 1.4e-46 153.6 In-house 3-238 (239) alignment
Range on Protein: 49-287
Range on HMM: 3-238/239.0
EKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGP-TKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESme
.|  |..|||| .|. ||.||.|| ..     ||||| .|..        |.|.|| .  .  ||||||      |.||     |  | ||..|||.|  
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds..

eTLTFAGMKISLESEEAMGDgFTVRTLA-VQAGKTKH-NVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGSQDTPVLVHCSAGCGRTGTICALDYarT
 |  .. ....|   | . | . .||.   | |.|.   | |.|.| |||. ||. || .. | |           | ..||||| ||||..  .|    
.tskycnlrvtlrktevfad.yiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvida..m

LLQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEE
| |. . . . .|. |  .| .|  |||| ||| ... || |
lrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 49-286 1.6e-46 153.5 In-house 4-238 (239) alignment
Range on Protein: 49-286
Range on HMM: 4-238/239.0
EKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGP-TKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESme
.|  |..|||| .|. ||.||.|| ..     ||||| .|..        |.|.|| .  .  ||||||      |.||     |  | ||..|||.|  
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds..

eTLTFAGMKISLESEEAMGDgFTVRTLA-VQAGKTKH-NVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGSQDTPVLVHCSAGCGRTGTICALDYarT
 |  .. ....|   | . | . .||.   | |.|.   | |.|.| |||. ||. || .. | |           | ..||||| ||||..  .|    
.tskycnlrvtlrktevfad.yiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvida..m

LLQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVE
| |. . . . .|. |  .| .|  |||| ||| ... || 
lrqakkqktvdifnyvkairedrphmvqtseqyvfihlavl

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 22-289 7e-46 151.6 In-house 17-277 (307) alignment
Range on Protein: 22-289
Range on HMM: 17-277/307.0
GFAKEFQELKNISSRQKRDKAFSTNhgekeynRTKNRYKDILPYDYSRIVLpEIKGVdGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNI
 .  ||..| . .      .|||.|         ||||.|.   | .|||. ...|.  ||||  ||.   .|   ...||||| .|. .|| |.| ...
alvdefrvlakktpegvtveafsan.......tdknryqdvkcqdkgrivv.kfdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekv

QVVVMACREYELGKLKCKRYWPESMEETLTFA--GMKISLESEEA--M---GDGFTVRTLAVQAGKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRt
. |.| |.  ||.|.||..|||    ..|.|.  .  ||..   |  .    |   | || |. ..    .... .. |||. ||.     |.|  . | 
esvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavr.

fvgSQDTPVLVHCSAGCGRTGTICALDYARTLLQTGRTeELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELV
    .  ||.|||||| ||.||| |. . .  . .|     .. ..| .|| ||   .||. ||  ... . |  
...ydtnpvvvhcsaGvGrsGtivaislvqdkmiaGin.ckdmkklveelrsqrhyaiqteaqylylhrvlleyf

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 53-285 1.4e-45 150.4 In-house 3-235 (237) alignment
Range on Protein: 53-285
Range on HMM: 3-235/237.0
NRTKNRYKDILPYDYSRIVLPEIKgvDGSDYINGNYIKGPT-KNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESmEETLT
|. |||| .|  ||.||.||       |||||| .|.||       |.||||||  . ||||.|.   .  |.||     |  .|||..|||.. ..  .
nkiknrygnivaydhsrvvlkgag..sgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpst.dqpaa

FAGMKISLESEEAMGDgFTVRTLAVQAGKTKHNV---TQFHYTAWPDHDVPRSATPLIELTRSF--RTFVGSQDTPVLVHCSAGCGRTGTICALDYarTL
.  . .||  .|.. | .|||.| ..   |...|    |...|.|||. ||. .. |. . .    |.   |. .| ..||||| |||| .  .|    |
ygvltvslkkkeefsd.ytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvida..ml

LQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAV
 |.   . . ... | ..  .|  ..|||.|| ......
rqakekkvvdiynyvysieedrpyiiqtkdqyvfihqti

0046846 (Phosphotyrosine protein) phosphatases II 79-289 8e-45 148.0 In-house 10-173 (176) alignment
Range on Protein: 79-289
Range on HMM: 10-173/176.0
DGSDYINGNYIKGPtkniMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESMEETLtfagmkisleseeamgdgftvrtlavqa
 ..||||.|.| |.    ...| |||||.|. ||..|. ...|..||. . |.|||.||| .|||| ... .                            
ldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi............................

gktkhnvtQFHYTAWPDHDVPRSaTPLIELTRSFRTFVGSQdTPVLVHCSAGCGRTGTICALDyartLLQTgrTEELSVFDIVANLRRQRV-AMVQTKEQ
        |.... ||||.|| . . |.|| .  |... .   |||||||||.|||||..|..    ||..     |||....| .|.||   .||| ||
........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llel..ekglsveealalvreqRplgavqtpeQ

YTLVYKAVEELV
|  .|... .| 
yrflyefellll

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 21-292 1.2e-44 147.2 In-house 24-292 (305) alignment
Range on Protein: 21-292
Range on HMM: 24-292/305.0
NGFAKEFQELKNISSRQKRDKAFSTNHGeKEYNRTKNRYKDILPYDYSRIVLPEIKgvdGSDYINGNYIKGPT-KNIMYLAAQGPLPKTVDDFWRMMISH
. . .||..| . .  .  ..|| .|.   . . |||||.|.   | | . | .      ||||  ||.  |   .  ...||||| .|.|.|| |.| .
dklreefrglakytrpdmtqvafnanqs.adiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqn

NIQVVVMACREYELGKLKCKRYWPESMEETLTFAGM-KIS-LESEEAMG--DGFTVRTLAVQA-GKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRt
... .|| |.  ||||||| .||| .. | |.. .   .  .     |       . .| .   |. |  | ....| |||  ||      .||  . | 
kveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsair.

fvGSQdTPVLVHCSAGCGRTGTICALDYARTLLQTGRtEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVNEE
  ||.  |..|||||| |||||| |..|    .   . .   . ..|  || ||   .|.  ||  ... . . . | 
..gsk.vpivvhcsagigrtgtivaieyilekiaenk.pcppmpelvkalrdqrafsiqndvqylfihrvmlnyflek

0049772 (Phosphotyrosine protein) phosphatases II 23-293 2.2e-44 147.8 In-house 18-284 (314) alignment
Range on Protein: 23-293
Range on HMM: 18-284/314.0
FAKEFQELKNISSRQKRDKAfsTNHGEKEYNRTKNRYKDILPYDySRIVLpEIKGVDGSDYINGNYIKGPtknIMYLAAQGPLPKTVDDF----------
. |....|...| .. ...   .  . .. ||.||||.||||.| .| .|    .|.|||||| .|..|.     ..|.||||. ||.||          
llklllvlnrrslsvlpelt..ilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyng

WRMMI--SHNIQVVVM---------------------ACREYELGklkckRYWPESMEETLTfagmkisleSEEAMGDGFtvrtlavqagktKHNVTQFH
|||..   .|. ..||                      ..  ..|      .....  |.|          .|   .. |            .... ...
wrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng.....neptaadlellk.........eelydpelf............erlgikyl

YTAWPDHDVPrSATPLIELTRSFRTFvgSQDTPVLVHCSAGCGRTGTICALDYARTLLQtgrteeLSVFDIVANLRRQRV-----AMVQTKEQYTLVYKA
.. .||...| .   . |. . ....  ....||||||.||.||||| ....|   ||.      .|. .... .|..|       .... |||  ...|
ripvpDgsap.lledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllg......vsleealedvrlkRpinpnpgfieqleqyefilea

VEELVNEEL
..|...  .
lleylkflk

0036282 (Phosphotyrosine protein) phosphatases II 80-283 3.2e-43 142.8 In-house 1-164 (174) alignment
Range on Protein: 80-283
Range on HMM: 1-164/174.0
GSDYINGNYIKGPTKNIMYLAAQGPLPktvddFWRMMISHNIQVVVMACREYELGKLKCKRYWPEsmeetltfagmkisleseeamgdgftvrtlavQAG
|||||| .....   .  ..| ||||.     ||.|. ...|..||| ..|.|||. || .||||                                   
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lre

KTKHNVTQFHYTAWPDHDVPRSATpLIELTRSFRTFVGS-QDTPVLVHCSAGCGRTGTICALDYARTLLQtgrTEELSVFDIVANLRRQRVAMVQTKEQY
  .... |..|. |||| || ... |.|. .  .... . .. |||||||||.|||||..|...  ..|    .    ..|.|. ||.||  |||| .||
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll...eslvdaldlvrelRlqrpgmvqtpsQy

TLVYK
  .|.
rflyy

0043147 (Phosphotyrosine protein) phosphatases II 79-283 1e-42 141.1 In-house 3-155 (172) alignment
Range on Protein: 79-283
Range on HMM: 3-155/172.0
DGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREyelgklkckrywpesmeetltfagmkisleseeamgdgftvrtlAVQA
.|||||| .|.... .   ..| ||||. |..|||||. ...|...|.....                                             . .
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel............................................lydp

GKTKHNVTQFHYTAWPDHDVPrSATPLIELTRSFRT-FVGSQDTPVLVHCSAGCGRTGTICALDYARtllqtgrtEELSVFDIVANLRRQRVAMVQTKEQ
 . .... |..|. ||||.|| ..  |.|. .  .. .. |.. |||||||||.|||||..|... .        . ||....|| .|..|  .||...|
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml........lglsleeavalvrekRpgavqnpsq

YTLVYK
| ..|.
yrflyy

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 22-287 1.1e-42 141.0 In-house 7-264 (283) alignment
Range on Protein: 22-287
Range on HMM: 7-264/283.0
GFAKEFQELKNISSRQKRdkafsTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGvdgsDYINGNYIK---GPTKNIMYLAAQGPLPKTVDDFWRMMIS
..   .. ||..|  ..      ..    . |..|||...|.|.|  |. |         ||||  .|       ..  |..||.|| .|| |||.|.  
nnklfrevlkrlsvpdld.....adiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfd

HNIQVVVMACREYELGKLKCKRYWPEsmEETLTFAGMKISLEsEEAMGDGFTVRTLAVQAG---KTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTF
..|  .||  .  |  . || .|||.  . .  .  . ..|. .|   . |... | ..     |..  .. . .  | . .       |. . .     
ekitaivmltklqedlrikCsqyWPk..rGsedyGeftvtlr.kettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislq

VGSQDTPVLVHCSAGCGRTGTICALDyaRTLLQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEE
  |...|..||||.| |||.. .|.    .. .      . || .| ..| ||. .|||..|| ||...| |
teskkgPivvhCstgiGrtavfiaas..asvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle

subfamily_ptpA1_pd Subfamily ptpA1 44-239 3.1e-42 139.8 In-house 38-248 (418) alignment
Range on Protein: 44-239
Range on HMM: 38-248/418.0
STNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNiMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWP
 |. |.|..| .|||| .||| ...|. | .|.  .|||||| ||| |   .  ....|||||.|. |||||.     ...||  || |  ..|| ||||
etsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk.qfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywp

ESME-ETLTFAGM------KISLESEEAMGDG---FTVRTLAVQAGKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFR----TFVGSQD--TPVLVHC
| .  | ..  |         |.|  | . |       | . .      ...||..|  ||||..|  . |. .| .|        . | |   |..|||
eqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhc

SAGCGRTGTICA
||| |||||.|.
sagvgrtgtfct

0049260 (Phosphotyrosine protein) phosphatases II 89-283 3.3e-42 139.1 In-house 2-144 (152) alignment
Range on Protein: 89-283
Range on HMM: 2-144/152.0
IKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWpesmeetltfagmkisleseeamgdgftvrtlavqagktkhnvtQF
|.|  .. ...|.|||.| |..|||||. ...|...|| ....|||||||..|.                                            |.
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................qy

HYTAWPDHDVPRSATPLIELTRSFRTFVGSQDTPVLVHCSAGCGRTGTICALDYARtllqtgrtEELSVFDIVANLRRQRVAMVQTKEQYTLVYK
... |||| || ..  |..| .  . .  ... |||||||||.|||||..|... .          .|....|| .|..|  .|....|. ..|.
lhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml........lgvsleeavalvrekRpgavpnpgqlrflye

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 20-289 9.8e-42 137.7 In-house 21-287 (305) alignment
Range on Protein: 20-289
Range on HMM: 21-287/305.0
ENGFAKEFQELKNISSRQKRdKAFStnhgeKEYNRTKNRYKDILPYDYSRIVLpeiKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISH
 .|. .||. .| .   .|  |||      .  .. ||||||.   |  |. |   .|    .||  ||.  ||.   .. .| || ||  ||| | . .
paglraefvamkrfndfekm.kafk.....eaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqd

NIQVVVMACREYELGKLKCKRYWPESMEETLTFA--GMKISLESEEAMGDGFTVRTLA--------V-QAGKTKHNVTQFHYTAWPDHDVPRSATPLIEL
... . | |   | |  ||  |..   ...|.|   | |||.  | .    |.  . |        .  .|.... ||..|.  |||  || . . ..||
kveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailel

TRSFRTFVGsqdtPVLVHCSAGCGRTGTICALDYARTLLQTGRTEELSvFDIVANLRRQRVAMVQTKEQYTLVYKAVEELV
    |.  |    |. |||||| ||||..  |.|    | .|.  | .   |.  .| ||   .|| .|| .|.. . . .
lekarpskg....pivvhcsagigrtgsvvmleyildqllagqiiedt.dkilqkireqrnnsiqtdaqylfvhqvilnyf

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 28-285 1e-39 130.9 In-house 15-265 (281) alignment
Range on Protein: 28-285
Range on HMM: 15-265/281.0
QELKNISSRQKRDKAFSTNHgekEYNRTKNRYKDILPYDYSRIVLPE-IKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVM
||. |.      | .   |.     |  |||| .|   | ||. |   .   . .|||  |||. |  .  |. .|||  .|  |||||.   |   .||
qefsnlpgdppsdlctvfnq...pvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivm

ACREYELGKLKCKRYWPESMEETLTFAGMKISLESEEAMGDGFTVRTLAVQAGKTKhNVTQFHYTAWPDHDVPRSATPLIELTRSFRTfvgsQDTPVLVH
 |.  |  . ||  |.|      | |  . .| |         | |      |.|.  .|.. .  ||| .|| |.  .... |  |.    . || ..|
lcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetr.lithwlwkewpdwqvpessevmlkilrkira....rstppvih

CSAGCGRTGTICALDYARTLLQTGRTEElSVFDIVANLRR-QRVAMVQTKEQYTLVYKAV
|||| ||.||. |.. |   ...  |    . .||. ||   | | ||| .|| |..| .
csagvgrsgtlmaveialqsihshftlp.dikqivshlrvtgraasvqtlqqymliwkvl

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 51-287 2.3e-38 126.8 In-house 33-268 (285) alignment
Range on Protein: 51-287
Range on HMM: 33-268/285.0
EYNRTKNRYKDILPYDYSRIVLpeiKGVDgSDYINGNYIKGPTKN-IMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESMEET
| |   ||| |.   . .|.||   |  |  |||  .... | |.   |...|||||.|. |||.|.   .|  |.| |  .| |  ||  |.|| . | 
eanpdlnryadvrcieetrvvl...knhd.rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgev

LTFAGMKISLE-S-EEAMgDGFTVRTLAVQAGK----TKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTfVGSQDTPVLVHCSAGCGRTGTICALDYA
. |   .|.|    |||.  |  . .|.|   .        . . .   |||.  |  | |.||| .  .  |  ...|. |||||| ||| |.  .|||
vkfgkyeitlteckeeai.agtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkk.vnpkekpicvhcsagvgrtatfvgidya

RTLLQtgRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEE
   .      .. ..||| ..|  |.  ||.. |. ..|  . |
tirim..enpniemldivremramrfqavqshmqflflyvvlme

0044763 (Phosphotyrosine protein) phosphatases II 64-290 3e-38 126.6 In-house 1-172 (178) alignment
Range on Protein: 64-290
Range on HMM: 1-172/178.0
PYDYSRIVLPEIKGVDGSDYINGNYIKGPtkniMYLAAQGPlpktvDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESMEetltfagmkislesee
|.| .| .|... |. .||||| ..| .     .||....|      |.....  ..|...|. . |.|||.||| .||||...                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

amgdgftvrtlavqagktkhnvTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGSQDTPVLVHCSAGCGRTGTICALDYARTLlqtgrteELSVFDIVAN
                       |.... .|||.|| .   . |...  .... ... ||||||||| ||.||..|... ..|        ||...... 
......................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.......glsleeaiel

LRRQRVaMVQTKEQYTLVYKAVEELVN
.|..|  .|.. .|.  .|.  ..| .
vrerRp.ivpnpgqlrqLyefelrllk

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 20-294 1.3e-36 121.0 In-house 5-264 (267) alignment
Range on Protein: 20-294
Range on HMM: 5-264/267.0
ENGFAKEFQELKNISSRQKRdkaFSTNHGEKeyNRTKNRYKDILPYDYSRIVLPEIKgvdgSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISH
|  . |||...|.||. . .    |.  .||  |. .||. | |||| .|..| . .     .|||  |..|  .. .... |.|| .|. ||. ... .
eceiekefelikkisdtsst...isqsiaek..nqernrlddnlpyddtrvilrtke....eeyinasyvegyktknafivtqdplkntitdfltvihdq

NIQVVVMACREyelGKLKCKRYWPESMEETLTFAGMKI--SLESEEamgDGFTVRTLAVQA-GKTKHNVTQFHYTAWPDHDVP-RSATPLIELTRsfRTF
.. |.|.  .    .. . ...||  | ..  .  . .  ||| ||   . . . || ..   .. |||| ..|  |           ||. .    .  
kvpvivlltkv...ftdnirlfwPPkmgqakkyqdltvehslekee...ndyqiitlelkfknesahnvtlyyykkwnintnnkpylkplfgila..knq

VGSQDTPVLVHCSAGCGRTGTICALDyarTLLQTGRTEEL-SVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVNEELR
.   . |..|.||.| ||.||   .|   . |.  .||.   .|| . ..| ||...|.|||.|  ... . |  .  |.
lengnrPlvvacsdGvGrsGtflvid...sqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyaegrlk

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 53-301 1.4e-34 114.4 In-house 43-284 (288) alignment
Range on Protein: 53-301
Range on HMM: 43-284/288.0
NRTKNRYKDILPYDYSRIVLPeikgVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESMEETLTF
| |..||...   |..|. |      |   ||. | .     .   . || ||  |.. .|.|... ... .|| |.  |.|| | . |.|  . |.  .
nptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekari

AGMKI-SLESEEAMGDGFTVRTLAV-QAGKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFrtfvGSQDTPVLVHCSAGCGRTGTICALDYARTLLQtg
  .     .. . .    .| .| . . |..|  | . |.  |.|. || .  . . |   .     | . |..||.||| |||||.     | . |.  
grlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgtlililialeslr..

RTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAV-EELVNEELRKQNHLYV
 .. |..  ..|.|| .|   .||. ||  |.. | |||.    ... ...|
lddflgirsllaklreerfkaiqtemqylyvhrcvleelllkkykvlredfv

0051082 (Phosphotyrosine protein) phosphatases II 81-286 1.5e-34 114.1 In-house 3-150 (151) alignment
Range on Protein: 81-286
Range on HMM: 3-150/151.0
SDYINGNYIKGPtknimYLAAQGPLPktvdDFWRMMISHNIQVVVMACREYELGklKCKRYWPESMeetltfagmkisleseeamgdgftvrtlavqagk
||||| .|. |      ... .|||.    ||.... ...|...|. . |.| |  .|..|.||                                    
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

tkHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTfvgSQDTPVLVHCSAGCGRTGTICALDYARtlLQtgrteeLSVFDIVANLRRQRVAMVQTKEQYTL
  ..|...... |||...| |   ..|. . ..     .. |||||||||.|||||..||.     |.      .|...... .|..|  .||...|. .
..ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylml..lg......vsleealeeyrlkrpgvvqpnqqflf

VYKAVE
...|..
qlfall

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 83-282 1.1e-33 111.3 In-house 77-275 (301) alignment
Range on Protein: 83-282
Range on HMM: 77-275/301.0
YINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESMEETLTFAGMKISLESEE-AMGDGFTVRTLAVQAGKT
 |  |.|. . .   ..|.||||..| .||| |.. .... .|| ... |  . ||. | | ...|.|     || ....|  . .  . ||| |.    
PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstg

K---HNVTQFHYTAWPDHDVPRSATPLIELTRsfrtFVGSQDTPVLVHCSAGCGRTGTICALDYARTLLQTGRTEELSvfDIVANLRRQRVAMVQTKEQ-
|   . || . |. |.|..||.| . | .|      .|   . |..|||||| ||. .  . .|    ... .| ||.  . ...|| .|   |||..| 
kfatrtvthyqysewtdrgvPkshaelfdlme....lvkksekPivvhcsaGiGrsvafigteylareveadptielt..ealkhlrehrwngvqtnsql

YTLVY
| .  
ywmtl

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 32-201 1.8e-32 107.4 In-house 14-182 (297) alignment
Range on Protein: 32-201
Range on HMM: 14-182/297.0
NISSRQKRDKAFSTNHgeKEYNRTKNRYKDILPYDYSRIVLpeIKGVDGSDYINGNYIKGPT--KNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACR
..  ...| ..||. .  ..    ||||.||| .| .|. |   ... ..|||| .|.  |   ... |. ||||| .||||||...  ....|.|| ..
dllldeargesfssak..rnsslrknryrdilatddtrvkl..lrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvak

EYELGKLKCKRYWPESMEETLTFAGMKIS---LESEEamGDGFTVRTLAVQAGKTKHNVTQFHYTAWPDHDVPRS
  | |. ||  |||.. .| |. . . .      |.|   |   .  | .   . .  |.   . .|||| ||  
lqedGrdkcapywpsvvqerlkagdvvveflsstsde..fdrviltelqliyrsesrvvrhvqflswpdhGvpsd

PTPc_DSPc_SM00012 185-285 2.8e-32 106.4 In-house 2-103 (105) alignment
Range on Protein: 185-285
Range on HMM: 2-103/105.0
VTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGSQD--TPVLVHCSAGCGRTGTICALDYARTLLQTGRtEELSVFDIVANLRRQRVAMVQTKEQYTLVY
|...|||.|||| ||.......|| |.....   ..  .||.||||||.|||||..|||..   |.... .|...|.||  ||.||  ||||.|||  .|
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket.kevdifqivkelrkqRpgmvqteeqylfly

KAV
.|.
ral

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 21-284 3e-32 106.4 In-house 27-285 (310) alignment
Range on Protein: 21-284
Range on HMM: 27-285/310.0
NGFAKEFQELKnisSRQKRDKAFSTNhgekEYNRTKNRYKDILPYDYSRIVLpEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHN
.|..|... |    ..|    .. .     . .  |||| |..  | ||. | .|      |||  ||.|       .. .|||| .|. |||||..   
eglvkqyrkld...akqdssltyeay....kkymhknrysdvvcldtsrvkl.kidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqer

IQVVVMACREYELGKLKCKRYWPeSMEETLTFAGMKISLESEEAmgDGFTVRTLAVQ------------AGKTKHNVTQFHYTAWPDHDVPRSATPliel
 . ... |.  | |. ||  ||| |.  | |.  ....  || .  . | .  |||             |   .  |.  ..  |||  ||         
aesilllckvgeegrpkcvgywp.slgvtetygcirvtnlsess..eefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekch....

TRSFRTFVGSQDTPVLVHCSAGCGRTGTICALDYARTLLQTGrtEELSVFDIVANLRRQRVAMVQTKEQYTLVYKA
|   | .   .  |..|||||| .|.....||...   |. |  ... . .....|...|.  .||. ||... . 
tvpqrllaqvrhgpcvvhcsagkdrlyvvvalklkidkldrg..lkvdaeevktellksraiciqtelqyliidrv

subfamily_egg_pd Subfamily egg 36-291 6.8e-31 102.1 In-house 25-272 (307) alignment
Range on Protein: 36-291
Range on HMM: 25-272/307.0
RQKRDKAFstNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELgk
    ....  ..  .. |..| | | .   |.||. |   .|    |.|  |..||      .. || ||  ||||||||.   ..| .||     |   
esvdeisl..ttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..

LKCKRYWPESMEETLTF--AGMKIS-LESEEAMGDGFTVRTLAVqAGKTKHNVTQFHYTaWPDHDVPRSATPLiELTRSFRtfvgSQDTPVLVHCSAGCG
 .|. ||| . ...| .   ...|  |. ...    |.|  | .  |  . .    |.  .  . .    .|| .. |  |       .||.|..  |. 
erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklkl.vGgddeerflehwq.gdvnnssdvyspl.rvlrklr....nlskpvvvqdilGvs

RTGTICALDYARTLLQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVNE
...|. |.. |   |  | .    |   |  ||..|   |..  .| .||. |  .. .
kaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrd

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 55-297 2.7e-27 90.3 In-house 45-285 (312) alignment
Range on Protein: 55-297
Range on HMM: 45-285/312.0
TKNRYKDILPYDYSRIVLpeikGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPE-----SMEET
  ||| .|  .|  |. |      |   ||  |..|  ||   ....|||| .|.  ||.. .|     ... |   | |  || .|  .      .|. 
dlnrypniqcwdrgrftl....agdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledh

LTFAGMKISLESEEAMGDGFTVRTLAV--QAGKTKHNVTQFHYTAWPDHDVPRSATPLIELTrsfrTFVGSQDTPVLVHCSAGCGRTGTICALDYARTLL
  .. .   .|      |  | | | |  .|   . .. .. ...|||| .| |      |     . |  .  ||. ||||| |||||.. ..   . |
rvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrll....savkkdkkpviahcsagvgrtgtlaliesmiaal

QTGRTEElsVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELV-NEELRKQN
.  | ..  | |.   ||..|   |..  ||  . ..| |.. .. | |.|
rhprkqn..vkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglykrn

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 68-286 3.2e-27 90.4 In-house 33-256 (290) alignment
Range on Protein: 68-286
Range on HMM: 33-256/290.0
SRIVLPEIKGVDGSDYINGNYIKGPTkNIMYLAAQGPLPKT-------VDDFWRMMISHNIQVVVMACREYE----LGKLKCKRYWPESMEETLTFAGMK
.|.|| . .    .|||  |... |  ..  .. | |. |.       . .|| |.   ... ||| |   |    ...  |..| |||..| |.| |..
trvvLkgygkrfnddyiHAnrvtcpn.glrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkglt

ISLESEEaMGDGFTVRTLAVQAGK-TKHNVTQFHYTAWPDHDVPRSATPLIELTRsfrtFVGSQDTPVLVHCSAGCGRTGTICALDYARTLLQtGRTEEL
..  | |   |.. .|.| |. ..  .. ||   .  | .  |...   |..| .    .|  ..|||.|||  |  |  .. |.. .  ..  . ....
vkCkske.keddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliq....kvkasktpvivHcvdGiSrsAalaaiilgyQkia.etsgsv

SVFDIVANLRRQRVAMVQTKEQYTLVYKAVE
.. |.. .||.||  ......... |  .. 
kledvlkalrkqralaitsalelafvdagiv

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 53-289 6.7e-27 88.9 In-house 47-279 (303) alignment
Range on Protein: 53-289
Range on HMM: 47-279/303.0
NRTKNRYKDILPYDYSRIVLPEikgvdgSDYINGNYIKGPTKNIMYLaAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESmEETLTF
|  |||. |..  |.|.. | .      | ||  .|..  ...   | .| ||..|  |||.|.|  ....|..   . |  ||  .  .|.  .. | |
nmdknrfvdvicldhskvklsd......ssyihasyleldsskkail.tqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprn.qdflkf

AGMKISLES--EEAMGDGFTVRTLAVQAGKTKHNVTQFHYTAWPDHDVPRSATP-----LIELTRSFRTFvgSQDTPVLVHCSAGCGRTGTICALDYART
    | .    .  .|||.... |.|  |. |  .   || |||  ..|  ..|     . .|   .| .  |. || .    .||||.||.. .. |  
eersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrky..sdstptvymslsgcgragtfalfetahl

LLQTGRtEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELV
 |.. .   | .   . |.|  |.  ||   |...||  . | |
slhseq.asldlvkclenvrngrlhavqnlsqfsvvytllaehv

0048076 (Phosphotyrosine protein) phosphatases II 141-288 8.7e-27 89.0 In-house 2-142 (145) alignment
Range on Protein: 141-288
Range on HMM: 2-142/145.0
YWPESMEETLTFAGMKISLESEEAMGDGFT-VRTLAVQAGKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGSQdTPVLVHCSAGCGRTGTICA
|||    . | . ..   |. |.    |.| | .|.      .....|..|. ||||.|| ..  |.|. .  .... .   |||||||||.|||||..|
ywpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlva

LDYARTllqtgrtEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEEL
..  ..       . .|...... .|.||  .|.. .|.  .|....||
aylmll.......lgvsleealelvrsqrpgavpnpgqlrflyefelel

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 54-151 1.8e-26 87.7 In-house 48-159 (350) alignment
Range on Protein: 54-151
Range on HMM: 48-159/350.0
RTKNRYKDILPYDYSRIVLP--------EIKGVDGSDYINGNYIKGP----TK--NIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCK
 .|||||.||||. ||. |.          . . ..|||| ||.| .        .  |.|.|.|||.|||||.....  ...|...   . ||.  || 
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

RYWPESMEETLT
|||.|   .  |
rYWqegsyddit

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 104-282 2.7e-26 86.8 In-house 99-281 (302) alignment
Range on Protein: 104-282
Range on HMM: 99-281/302.0
PLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESMEETLTFAGMKISLESEEAMG------DGFTVRTLAVQAG----KTKHNVTQFHYTAW
|  .|.. .| ..  .|. .||  |   | .. ||  |. . ....|.|    .   | .          .|.. |. ..      |.|. |  ....||
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PDHDVPRSATPLIELTRsfrtFVGSQDTPVLVHCSAGCGRTGTICALDYARTLLQTGRTEELsvFDIVANLRRQRVAMVQTKEQYTLVY
|||  |. | . ... .    |  |  . |||||||| |||||. |. |   | .. .. .|   .||  .|. |   ||...| . . 
pdhGapkeaytaldilk....fcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdl..lsivlpvrqcryGavqdeqqliyll

0048179 (Phosphotyrosine protein) phosphatases II 114-283 2.9e-25 84.1 In-house 23-139 (144) alignment
Range on Protein: 114-283
Range on HMM: 23-139/144.0
RMMISHNIQVVVMACREYELGKLKCKrywpesmeetltfagmkisleseeamgdgftvrtlavqagktkhnVTQFHYTAWPDHDVPRSATPLIELTRSFR
 .. ...|  |.  . |||   |..                                              ..|.... ||||.|| ... |.|. . ..
ellkklgittvinlteeyepeflere.............................................giqylhlpwpDhgvpdllellleflefie

TFVGsQDTPVLVHCSAGCGRTGTICALDYARtllqtgrTEELSVFDIVANLRRQRVAMVQTKEQYTLVYK
...  .. |||||||||.|||||..|..  .       .. ||.....| .|..|  .|.. .|.  ...
eale.eggpvlVHCsaGvgRtgtlvaaylmk.......klglsleealalvrsrrpgavpnpgqlrfLle

subfamily_CG42327_pd Subfamily CG42327 54-208 5.4e-25 82.7 In-house 29-186 (319) alignment
Range on Protein: 54-208
Range on HMM: 29-186/319.0
RTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTK-NIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPES--MEETL
. |.|. ...|   .|.||..|   | . |.. .|..|. . .  |.||| .| ..  ||||..   . .|.| ..  .|||  .| .|.| .  ...| 
kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnts

TFAGMKISLESEEaMGDGFTVRTLAVQA--GKTKHNVTQFHYtAWPDHDVPRSATPLIEL
..  ....|   |  .| . . || ..   ..   ..| . |  |.. .|| . ..|| .
lyGdilvtlkgre.vkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliam

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 53-295 5.1e-24 79.2 In-house 51-291 (302) alignment
Range on Protein: 53-295
Range on HMM: 51-291/302.0
NRTKNRYKDILPYDYSRIVLPEIKgvdgSDYINGNYIKGPT-KNIMYLaAQGPLPKTV---DDFWRMMISHNIQVVVMACREYELGKlKCKRYWPESMEE
|  ||. .|.  .|  .. |.. .     .|.|.  .. |  .. ..| || |  ...   ..||||. ...|. ||.. .| || |   . ..|. ...
nlkknqsedvpildsnlvkleaep....dsyvnaskvevPeltrsiil.aQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgd

TLTFAGMKIS---LESEEAMGDGFTVRTLAVQAGKTK-HNVTqfHYTAWPDHDVPRSATPLIELTRSFRTFVGSQDTPVLVHCSAGCGRTGTICALDYAR
 ...  | .     |. |.. . ...  |      .   ||.  . | |... || . . ||.   .  .   . | ....    |.|| |.. .|  | 
ykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvy..vltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavav

TLLQTGrtEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVNEELRK
. ||.|  .|  . .||...| || ..|.. .||. .| |.  .. ....|
eklqkg..kepnikeivksiRsqRpravdslkQyvslyialllyikkkvtk

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 99-289 1.7e-22 74.7 In-house 39-221 (255) alignment
Range on Protein: 99-289
Range on HMM: 39-221/255.0
LaaqgplpkTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESMEETLTFAGMKISLESeeAMGDgFTVRTLA--VQAG--KTKHNVTQFHYTAWP
|        ||| |.....  . .|||| |  .| |. ||..|.|   .| | .| ....     .. |   .|||    . |  |  |.|. ..|. |.
l........tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssad.vvlrtleitstlgekkkthtvkhysykGWi

DHDVPRSATPLIELtrsFRTFVGSqdTPVLVHCSAGCGRTGTICALDYART----LLQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELV
..  |. |  . ..   ..    |   .|.||||.| ||. .    ...       |.|  | ||    .. .|| .| . ..|  | ..    | .||
eknaPelareilni...lkvvrds..ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 182-287 1.7e-20 67.8 In-house 88-192 (440) alignment
Range on Protein: 182-287
Range on HMM: 88-192/440.0
KHNVTQFHYTAWPDHDVPRSATPLIELTRSFRT-FVGSQDTPVLVHCSAGCGRTGTICALDYarTLLQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTL
 . . |.|| .|||. ||. | |.... .        . . |.|||||||.|||| | |.|    | .. |.... .| .. ..| .|  |||| |||..
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavds..ilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf

VYKAVEE
|..|| |
vheavle

subfamily_hpo-7_pd Subfamily hpo-7 98-295 2e-19 64.5 In-house 41-233 (263) alignment
Range on Protein: 98-295
Range on HMM: 41-233/263.0
YLaaqgpLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESMEETLTFAGMKISLESEEAmgdGFTVRTLAVQA----GKTKHNVTQFHYTAW
 |     | .|.| |....   . .|||| |  .| |. ||..|.|   .| . .| ....            ..|| .       |. |.|... |. |
sl.....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs...dvllktlellstlgeKkkthtvkhysykgW

PDHDVPRSATPLIELtrsFRTFVGSqdTPVLVHCSAGCGRTGTICALDYART----LLQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELV
...  |. |   ...   ..   .|   .. ||||.| ||.      . .       |.|  | ||    .. .|| .| . ..|  |       | ..|
iekndpelareilni...lkvarns..kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfv

NEELRK
 ..  |
lnnfak

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 183-288 8.7e-19 62.4 In-house 215-343 (350) alignment
Range on Protein: 183-288
Range on HMM: 215-343/350.0
HNVTQFHYTAWPDH---DVPRSATPLIE-------LTRSFRTFVGSQDTPVLVHCSAGCGRTGTICALDYART---LLQ--TGRTEEL--------SVFD
. | |...  |.|      |.|  . .|          .   .  .. .|.|||||||.|||||...||.       |.  | . ..|         .. 
yvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisi

IVANLRRQRVAMVQTKEQYTLVYKAVEEL
|| .||.||. |||...|.  .|.|.  .
ivnelrkqrismvqnldqfifiYeallfy

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 54-147 1.8e-18 61.0 In-house 49-158 (349) alignment
Range on Protein: 54-147
Range on HMM: 49-158/349.0
RTKNRYKDILPYDYSRIVLPE--------------IKGVDGSDYINGNYIKGPTKN--IMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLK
 .||||||||||..||..|..               ..    |||| ||.| .  .    |.| | ||| |||||.....  ....|.    . ||.  |
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslek

CKRYWPESME
|..|| |   
cdiywqelsy

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 97-283 7e-18 59.5 In-house 5-197 (198) alignment
Range on Protein: 97-283
Range on HMM: 5-197/198.0
MYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESMEETLTFAGMKISLESEEAMGDgFTVRTLA----VQAGKTKHNVTQFHYTA
 |.|.| || .|. |||.|.       .||   .    .     ||| .   |  .. . .. ..  .  | .|. .|     . |  .  ..... .|.
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpd.ytitaliltnnttappstreishyqfts

WPDHDVPRSATPL--IELTRS-FRTFVGSQDTPVLVHCSAGCGRTGTICALDYARTLLQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYK
| ..  |  |  .  .  .|   . .   .|.||.|||| | | || . |||      .  .|  . .|..   ||. |. .. . ..| ..|.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 97-283 7.5e-18 59.4 In-house 6-198 (199) alignment
Range on Protein: 97-283
Range on HMM: 6-198/199.0
MYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESMEETLTFAGMKISLESEEAMGDgFTVRTLA----VQAGKTKHNVTQFHYTA
 |.|.| || .|. |||.|.       .||   .    .     ||| .   |  .. . .. ..  .  | .|. .|     . |  .  ..... .|.
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpd.ytitaliltnnttappstreishyqfts

WPDHDVPRSATPL--IELTRS-FRTFVGSQDTPVLVHCSAGCGRTGTICALDYARTLLQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYK
| ..  |  |  .  .  .|   . .   .|.||.|||| | | || . |||      .  .|  . .|..   ||. |. .. . ..| ..|.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_CG42327_pd Subfamily CG42327 213-287 1.5e-15 51.7 In-house 240-313 (319) alignment
Range on Protein: 213-287
Range on HMM: 240-313/319.0
RTFVGSQDTPVLVHCSAGCGRTGTICALDYARTLLQTGRtEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEE
|.   ..  |. |||| | ||||.. | | |   |.. . . . . ..|  .||.|   |.||||| ..|| . |
rsgtresqGPlvvhcsdGvGrtGlviasdiairsleesk.rsvdiPqlvssvrrdrasavltkeqyefiykvlse

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 210-285 2.1e-13 44.3 In-house 255-340 (349) alignment
Range on Protein: 210-285
Range on HMM: 255-340/349.0
RSFRTFVGSQDTPVLVHCSAGCGRTGTICALDYARTLLQTGRTEE--L--------SVFDIVANLRRQRVAMVQTKEQYTLVYKAV
 .   .  .| ...||||||||||||... ||.   .|.  . |   .         .. || .||.||..|||   |.  .|.|.
farlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyeal

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 219-287 4.9e-13 43.6 In-house 227-293 (297) alignment
Range on Protein: 219-287
Range on HMM: 227-293/297.0
QDTPVLVHCSAGCGRTGTICALDYARTLLQTGRTEElsVFDIVANLRRQRVAMVQTKEQYTLVYKAVEE
.....||||||| ||.| .   |   . |. .|  .  |  |.  || ||  .||| ||..|.|.|| .
rnayllvhcsaGvGrsGvvvlsdvilaklrkkripd..vaailsilreqrarlvqtleqfellydavlk

subfamily_eak_pd Subfamily eak 30-200 1.7e-12 41.4 In-house 29-196 (332) alignment
Range on Protein: 30-200
Range on HMM: 29-196/332.0
LKNISSRQKRDKAFSTNHGEKEYNRTKNrYKDILPYDYSRIVLPEIKgVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACR
.. ..  ..  .. | . ...  .  .|   .|.|||.  . |   .  .   |||   .. .     |. .  .  . |  ||.|..  .   .|.   
inivadlddyqrllsisetarleavnrn.vvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlle

EYELGKLKCKRYWPESMEETLTFAGMKISLESEeAMGDGFTVRTLAVQAGKTKHNVTQFHYTAWPDHDVPR
. ||.  |  .|.|.   | | |  ...   .     . . .| | .. |   |.|  ...  | . ..|.
dvelkleksdkyfpdktreelkfGildverkef.vkrniletrllelskGnethrvlhykvfGwtettlpk

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 108-288 2.3e-11 36.9 In-house 130-308 (346) alignment
Range on Protein: 108-288
Range on HMM: 130-308/346.0
TVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESMEETLTfAGMKISLESEEAMGDGFTVRTLAVQAGKTKHNVTQFHYT-AWPDHDVPRSATPLI
 |.||| |.   .|..| .   .  | .     .  |      |   | |     .  ||        .  |..   . | |.   |   . |  . |.|
fvedfwymiyqeqihlvylmvpddklkntttslfndenggyqyt.gkmfinnrradvsgdpkeytievlpegnsdsvicqvhhhapwkhlqqppktlpii

ELTRSFRTFVGSQDTPVLVHCSAGCGRTGTICALDYARTLLQTGRteELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEEL
 .   | .    |.. | |    ||||. ..    ||   |. |   |  ...|. |...||   |..  ||. .|  | . 
kmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngi..epniceimknikqqrpggvesfaqyasiyaivfdy

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 51-91 3.5e-10 33.8 In-house 45-85 (440) alignment
Range on Protein: 51-91
Range on HMM: 45-85/440.0
EYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKG
  |. ||||..|| ||.||..| |.|||  |||||  ||.|
pnnkvknryrnilaydhsrvmleevkgvpdsdyinasying

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 44-103 1.1e-09 32.3 In-house 39-95 (95) alignment
Range on Protein: 44-103
Range on HMM: 39-95/95.0
STNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKgvdGSDYINGNYIKGPTKNIMYLAAQG
.   |  | |  |||. .|.||| .|.||   .    |||||  .. | ...  |.||||
pytvgsseanipknrflnifpydatrvvlttkr...dsdyinacfvdgyarkncyiaaqg

PTEN_1 182-283 1.4e-09 33.0 In-house 91-187 (196) alignment
Range on Protein: 182-283
Range on HMM: 91-187/196.0
KHNVTQFHYTAWPDHDVPRSAtPLIELTRSFRTFVGS--QDTPVLVHCSAGCGRTGTICAldyaRTLLQTGRteeLSVFDIVANLRRQR-VAMVQTKEQY
...  ...   ..|| .|  .  |..  .||   . |  .   ||||| || ||.||..|      |...|.   |.. . .. .|..| ...... .| 
fksgveylhfpieDhgapsls.elfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva....ayLmykgk...ltadeAlelvrekRppgapnspsqe

TLVYK
 |.. 
rlley

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 48-125 1.6e-09 31.8 In-house 32-115 (347) alignment
Range on Protein: 48-125
Range on HMM: 32-115/347.0
GEKEYNRTKNRYKDILPYDYSRIVL-PEIKG----VDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNI-QVVV
 | | . .||| ||    | .|.|| ||        |   |||  .||    .  |. .| |||.|| |||.|.   .. ||| 
vewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 46-94 3.1e-09 30.8 In-house 32-79 (244) alignment
Range on Protein: 46-94
Range on HMM: 32-79/244.0
NHGEKEYNRTKNRYKDILPYDYSRIVLPEIKgVDGSDYINGNYIKGPTK
       | ||||| .|||.| .|..|   |  .|||||| |||.|  .
tnavlsanatknryinilpfdetrvilsssk.kegsdyinanyiqgsqn

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 93-188 5.8e-09 29.8 In-house 233-323 (440) alignment
Range on Protein: 93-188
Range on HMM: 233-323/440.0
TKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACreyELGKLKCKRYWPESMeETLTFAGMKISLESEEAMgDGFTVRTLAVQAGKTKHNVTQF
.|.  ..|.| ||  || ||||..  ..|  ..|     .|    |  |||     ..||  . .     | | .   |||| ..  .  |.. ||
skknafiatqmpldstvldfwrlvhdyristiimln...qlndktcsiywpvnt.rsvtfgpftvghkgsenm.nrvkvrtlelkykeevheirqf

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 63-161 1.3e-08 29.2 In-house 3-86 (130) alignment
Range on Protein: 63-161
Range on HMM: 3-86/130.0
LPYDYSRIVlpeikgvdGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVM-ACREYElgklkcKRYWPESmeETLTFAGMKISLES
|....||.         | .||| ...    .   || .| || .|  |||.||.   . |.|.    | |        |||.|  | | .   .| . .
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee......deywpds..ePlewyeediivtl





0038934 (Phosphotyrosine protein) phosphatases II 186-290 1.5e-08 30.0 In-house 80-178 (194) alignment
Range on Protein: 186-290
Range on HMM: 80-178/194.0
TQFHYTAWPDHDvprsATPLIELTRSFRTFV-----GSQDTPVLVHCSAGCGRTGTICALDYARTllqtgrtEELSVFDIVANLRRQRVAMVQTKEQYTL
 ...   .||.     ..| .|....|  .|      ...  |.||| || |||||..|     .         .|. . .| .|. |  .... ...  
ieylklpfpddg....tvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyr.......lgmsaeeAialfrekRpgaipnqdylea

VYKAVEELVN
..| ..|| .
llkrykelrk

subfamily_PTPDC1_pd Subfamily PTPDC1 183-282 3.4e-08 28.2 In-house 80-169 (182) alignment
Range on Protein: 183-282
Range on HMM: 80-169/182.0
HNVTQFHYTAWPDHDVPrSATPLIELTRSFRTFVGSQdtPVLVHCSAGCGRTGTICAldyaRTLLQTgrtEELSVFDIVANLRRQRVAMVQTKEQYTLVY
..   ..  .|.|..|. | . .... .     .  .   | ||| || |||| . |      |. .   ..|.  . .  .| .|   .||.||  || 
eqgiyvynfgwkDygva.sleriLdivkvvafalqeg..kvavhChaGlGrtGvlia....cylvya...krltaekaiklvrskrpksiqtreqvelvk





subfamily_DSP23_pd Subfamily DSP23 219-283 1e-07 26.7 In-house 83-140 (148) alignment
Range on Protein: 219-283
Range on HMM: 83-140/148.0
QDTPVLVHCSAGCGRTGTICALDYArtllqtgRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYK
..  | |||  | |||||. |  .        . ..|.  . .|..||.|   |.| ||  ||..
kneavsvhcllgrgrtgtmlacylv.......kerklaaaeaiaevrrlrpgsvetveqeklvrd

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 224-287 4.5e-07 24.2 In-house 2-63 (69) alignment
Range on Protein: 224-287
Range on HMM: 2-63/69.0
LVHCSAGCGRTGTICALDYARTLLQTGRteELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEE
.||||.| |||||. |.    . ... .   . .|. |  .|. |  ||  . .| ... |. |
vvhcssgtgrtgtfiaimvemariksek..lvdifnnvqymrkcrpmmvmneieyifihdalve

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 225-287 5.5e-07 23.8 In-house 2-62 (69) alignment
Range on Protein: 225-287
Range on HMM: 2-62/69.0
VHCSAGCGRTGTICALDYARTLLQTGRteELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEE
||||.| |||||  |.    . ... .   . .|. |  .|. |  ||  ...| ... |. |
vhcssGtGrtGtfiaimvemariksek..lvdifnnvqymrkcrpmmvmneneymfihdalve

subfamily_VSP_pd Subfamily VSP 191-259 9.6e-07 22.9 In-house 99-167 (212) alignment
Range on Protein: 191-259
Range on HMM: 99-167/212.0
TAWPDHDVPRSaTPLIELTRSFRTFVGSQDTPV-LVHCSAGCGRTGT-ICALDYARTLLQTGRtEELSVFD
    ||.||.    |. .|. .. ..  .   |  .||  | ||||| .|||  |  ...| . | |  | 
iliddhnvpkl.eellvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetak.esldyfg

Y_phosphatase3 Tyrosine phosphatase family 208-240 3.2e-06 22.2 Pfam-A 113-144 (164) alignment
Range on Protein: 208-240
Range on HMM: 113-144/164.0
LTRSFRTFVGSQdTPVLVHCSAGCGRTGTICAL
... ....  .. .|||.||.||  ||| ..||
yrkvlealaeee.gpvlfHCtaGKDRTGvvaal

PTPc_motif_SM00404 185-240 4.3e-06 21.6 In-house 44-100 (140) alignment
Range on Protein: 185-240
Range on HMM: 44-100/140.0
VTQFHYTAWPDHD-VPRSATPLIELTRSFRTFVGSQDTPVLVHCSAGCGRTGTICAL
  .|..   | .|      .. .. . .|   . .. . ||||| ||  |..|... 
nsgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliia

DSPc Dual specificity phosphatase, catalytic domain 184-239 4.8e-06 21.5 Pfam-A 36-92 (133) alignment
Range on Protein: 184-239
Range on HMM: 36-92/133.0
NVTQFHYTAWPDHD-VPRSATPLIELTRSFRTFVGSQDTPVLVHCSAGCGRTGTICA
. ....|.  | .|      .. .| . .|   . ..   ||||| ||  |..|...
kkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatlii

DSPc Dual specificity phosphatase, catalytic domain 184-239 4.8e-06 21.5 In-house 36-92 (133) alignment
Range on Protein: 184-239
Range on HMM: 36-92/133.0
NVTQFHYTAWPDHD-VPRSATPLIELTRSFRTFVGSQDTPVLVHCSAGCGRTGTICA
. ....|.  | .|      .. .| . .|   . ..   ||||| ||  |..|...
kkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatlii

subfamily_PTEN_pd Subfamily PTEN 192-263 9.2e-06 20.8 In-house 86-157 (184) alignment
Range on Protein: 192-263
Range on HMM: 86-157/184.0
AWPDHDVPRsATPLIELTRSFRTFVGSQDTPV-LVHCSAGCGRTGTIC-ALDYARTLLqTGRTEELSVFDIVAN
   ||  |.    | |. .. .... .... |  ||| || ||||..  |. . ..|| .  .| |..|. .  
pfdDhnppp.lelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslll.ekaeealelfaeaRt