Gene PTPN14 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN14
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP074_AA protein Get Run
NvecP074_AA_1-122 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN14_pd Subfamily PTPN14 1-125 5.9e-65 214.2 In-house 177-300 (300) alignment 
Range on Protein: 1-125
Range on HMM: 177-300/300.0
MPTKQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLRQRTSTTRSSvHESKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQR
.|.|..|||.|.|.||||||.||.|...||..|..|.|.|..|.....| .||||||||||.||||||||.||.||.||....|..|.|...| |||.||
lpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseves.keskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqr

MLLVANFGQYRFVYSTVIHYIKNSR
||||....||.|||...|.|.||||
mllvqtlaqYkfvYkvlikylknsr
0050432 (Phosphotyrosine protein) phosphatases II 3-123 4.7e-38 126.6 In-house 193-301 (308) alignment 
Range on Protein: 3-123
Range on HMM: 193-301/308.0
TKQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLRqrtsttRSsvheskPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRML
... |||.| ..|.|||| ||..|...|.||..|.. .      ..      .|..||| |||||||..|. ||.. ... ...... .|. .||.||. 
dgesrtvthfhytnWpdhgvPpspeilldflelvrksl......pg......gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpg

LVANFGQYRFVYSTVIHYIKN
 | .. ||.|.| ....|.|.
mvqtpeqylflyralleylkl
0046845 (Phosphotyrosine protein) phosphatases II 3-123 7.4e-38 125.9 In-house 161-276 (284) alignment 
Range on Protein: 3-123
Range on HMM: 161-276/284.0
TKQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLRQRtsttrssvHESKPPVLVHCTAGVGRTGVIILTDLMIACIQNNK---RINIHHALVRLRRQ
|.. |||.| ..|.|||| ||..|...||||..|..|...        .....|..||| |||||||..|. ||.. ......   .... .|. |||.|
tgesrtvthfhytswpdhgvppspedlleflrlvrellen........lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreq

RMLLVANFGQYRFVYSTVIHYIKN
|.  | .. |||||| ....|.|.
Rpgmvqtleqyrfvyealleylkl
0036941 (Phosphotyrosine protein) phosphatases II 3-123 1.4e-37 125.0 In-house 164-279 (297) alignment 
Range on Protein: 3-123
Range on HMM: 164-279/297.0
TKQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLRQRTsttrssvhESKPPVLVHCTAGVGRTGVIILTDLMIACIQ---NNKRINIHHALVRLRRQ
....|||.| ..|.|||| ||..|.|.|.|...|.. .. .         |..|||||| |||||.|..|. |||. ...    .....|  |.  ||.|
ngesrtvthfhytgwpdhgvpespaslldfielvrkvlkll........psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReq

RMLLVANFGQYRFVYSTVIHYIKN
|.  | ...||||.| ......|.
Rpgavqtleqyrflyeallellkk
0051299 (Phosphotyrosine protein) phosphatases II 3-122 1.7e-37 124.9 In-house 178-287 (288) alignment 
Range on Protein: 3-122
Range on HMM: 178-287/288.0
TKQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLRQrtsttrssvhESKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRML
... |||.| ..|.|||| |||.|...|.|| .| . ..           ...||.||| |||||||..|. ||.. .......... .|. |||.||. 
dgesrtvthfhytnwpdhgvpdspellldflrlvrkala..........sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpg

LVANFGQYRFVYSTVIHYIK
.| .. |||||| ....|.|
mvqtpeqyrfvyealleylk
0039614 (Phosphotyrosine protein) phosphatases II 3-123 1.9e-37 124.7 In-house 179-291 (297) alignment 
Range on Protein: 3-123
Range on HMM: 179-291/297.0
TKQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLRQRTsttrssvhESKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRML
... |||.|.|.|.|||| ||......||||..|.. ....        ... ||||||.|||||||..|. .||. ... ...... .|. .||.||. 
ngesrtvthfqytgwpdhgvppslellleflelvrealael........pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpg

LVANFGQYRFVYSTVIHYIKN
 | ...||||.|  .....|.
avqtpsqyrflydallellkr
0045450 (Phosphotyrosine protein) phosphatases II 3-123 7.2e-37 123.2 In-house 191-306 (307) alignment 
Range on Protein: 3-123
Range on HMM: 191-306/307.0
TKQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLRQRtsttrssvHESKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKR---INIHHALVRLRRQ
|.. |||.| ..|.|||| ||... ..|.|...|.. ...        . .. ||||||.|||||||..|. .||. ......    ... .|. .||.|
tgesrtvthfhytgwpdhgvppsfeelldfieevrkalee........lpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreq

RMLLVANFGQYRFVYSTVIHYIKN
|.  | |..||||.|  .......
Rpgavqnpeqyrflyeallelllk
0040438 (Phosphotyrosine protein) phosphatases II 3-123 1e-36 122.2 In-house 168-278 (317) alignment 
Range on Protein: 3-123
Range on HMM: 168-278/317.0
TKQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLRQrtsttrssvhESKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRML
....|||.| ..|.|||| ||..|...|.||..|.. ..          ... ||||||.|||||||..|. .||. ... ...... .|. .||.||. 
dsesrtvthfhytgWpdhgvppspdllldfleavreale..........dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpg

LVANFGQYRFVYSTVIHYIKN
 | ...||||.|  ...|.|.
avqtpeqyrflydalleylkr
0047943 (Phosphotyrosine protein) phosphatases II 3-122 2.3e-36 121.1 In-house 162-273 (273) alignment 
Range on Protein: 3-122
Range on HMM: 162-273/273.0
TKQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLRQRTSTTrssvheskPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRML
|.. |||.|...|.|||| ||....|.|||...|.. .. .           .||.||| |||||||..|. ||.. ... ......  |. .||.||. 
tgesrtvthfhytgwpdhgvppslesllefielvrkalealpsn........gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpg

LVANFGQYRFVYSTVIHYIK
 | .. ||||.| ....|.|
mvqtpeqyrflyealleylk
0040439 (Phosphotyrosine protein) phosphatases II 3-123 2.6e-35 117.6 In-house 136-248 (249) alignment 
Range on Protein: 3-123
Range on HMM: 136-248/249.0
TKQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLRQRTsttrssvhESKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRML
... |||.|.|.|||||| ||... ..|.|...|.. ....        ... ||||||.|||||||..|. .||. ... ...... .|.  ||.||. 
dgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel........pkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpg

LVANFGQYRFVYSTVIHYIKN
 | |..||||.|  .......
avqnpeqyrflyeallelllk
DSPc_SM00195 4-122 2.7e-35 117.3 In-house 155-263 (263) alignment 
Range on Protein: 4-122
Range on HMM: 155-263/263.0
KQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLRQRTsttrssvhesKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRMLL
...|.|...|...|||| |||...|.||.| .|.. ....          ..|..||| |||||||.....|...  ....|...| . . .|| ||. .
eetrkvtqyqyknWpdhgvpdstksvlellravkksksts..........sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgm

VANFGQYRFVYSTVIHYIK
| .. ||.|.| ....|||
vqtleqYlfiyeaileyik
PTPc_SM00194 4-122 2.7e-35 117.3 In-house 155-263 (263) alignment 
Range on Protein: 4-122
Range on HMM: 155-263/263.0
KQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLRQRTsttrssvhesKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRMLL
...|.|...|...|||| |||...|.||.| .|.. ....          ..|..||| |||||||.....|...  ....|...| . . .|| ||. .
eetrkvtqyqyknWpdhgvpdstksvlellravkksksts..........sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgm

VANFGQYRFVYSTVIHYIK
| .. ||.|.| ....|||
vqtleqYlfiyeaileyik
0043336 (Phosphotyrosine protein) phosphatases II 3-122 4.2e-35 117.0 In-house 169-278 (278) alignment 
Range on Protein: 3-122
Range on HMM: 169-278/278.0
TKQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLRQrtsttrssvhESKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRML
... |||.|.....|||| ||......|.|| .| . ..           |. ||||||.|||||||..|. .|.. ............|. .||.||. 
dgesrtvthyhylgwpdhgvpeslsllldflkavreale..........dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpg

LVANFGQYRFVYSTVIHYIK
 | .. ||||.|  ...|.|
avqtpsqyrflyealleylk
0042113 (Phosphotyrosine protein) phosphatases II 3-122 1e-34 115.4 In-house 134-244 (245) alignment 
Range on Protein: 3-122
Range on HMM: 134-244/245.0
TKQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLRQRtsttrssvhESKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRML
....|.|.|.....|||| |||.. ..|.||. |.. ...          |. ||||||.|||||||..|. .||. ... ...... .|. .||.||. 
ddesrevihyhylpwpdhgvpdllellldflefvrkalae.........dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpg

LVANFGQYRFVYSTVIHYIK
 | ...||||.|  .....|
avqtpsqyrflyeallellk
0045098 (Phosphotyrosine protein) phosphatases II 3-122 1.7e-34 114.9 In-house 150-273 (278) alignment 
Range on Protein: 3-122
Range on HMM: 150-273/278.0
TKQQRTVYHVQFTDWPDHRVPDDP--TSFLEFLDQVESLRQRTSTTRSS---VHESKPPVLVHCTAGVGRTGVIILTDLMIACIqnNKRINIHHALVRLR
. ..|.|.|.... |||| ||..|  .||||.|..... ...  .  .|   ...|. |||||| |||||||.... .||. ..  ...... .|.  ||
dlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelr

RQRML-LVANFGQYRFVYSTVIHYIK
.||.   | |..||||.|  ......
sqRpglavqnleqyrflyefllelll
subfamily_PTPN3_pd Subfamily PTPN3 3-121 1.8e-34 114.0 In-house 167-275 (280) alignment 
Range on Protein: 3-121
Range on HMM: 167-275/280.0
TKQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLRqrtsttrssvHESKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRML
||..|.. ..|...|||| ||||...||||...|..||          . .. ||.|||.||.|||||.|| .. .| |.... ... . . ..| ||. 
tkeerkilqlqylaWpdhgvPddsadflefvervrklr..........sgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqram

LVANFGQYRFVYSTVIHYI
|| . .||.||  ....  
lvqtasqykfvCeailkvy
subfamily_PTPRD_pd Subfamily PTPRD 4-123 1.9e-34 114.3 In-house 174-283 (564) alignment 
Range on Protein: 4-123
Range on HMM: 174-283/564.0
KQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLRQrtsttrssvhESKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRMLL
...|.| . .||.|||| ||. .||.|.....|..|..          . . |..||| |||||||. |  | |.  |...| ..|   . .||.||  .
sesreVrqFhFtsWPdhgvpesatslLdlirkvralne..........pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnam

VANFGQYRFVYSTVIHYIKN
| .  || |..... .... 
VqteeQYiFiheailealac
0037934 (Phosphotyrosine protein) phosphatases II 3-121 7.5e-33 109.5 In-house 129-242 (243) alignment 
Range on Protein: 3-121
Range on HMM: 129-242/243.0
TKQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLRQRTSTTRssVHESKPPVLVHCTAGVGRTGVIILTDLMIACIqnnkRINIHHALVRLRRQRML
....|.|.|.... |||| |||.|...|.|||.| .  ... . .  .  |. ||||||.|||||||..|. .||. ..    .... .|. .||.||. 
ddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsll..aldsggpvlVHCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpg

-LVANFGQYRFVYSTVIHYI
  | ...||||.|  .....
kavqtpsqyrflyeallell
Y_phosphatase Protein-tyrosine phosphatase 5-118 9.9e-33 108.9 Pfam-A 131-234 (235) alignment 
Range on Protein: 5-118
Range on HMM: 131-234/235.0
QQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLRqrtsttrssvHESKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRMLLV
..|.|.....|.|||| ||..|.|.|.....||. .          .... ||.||| |||||||.... |... ...... ... ... .||.||. .|
ekrevkqlhytnWpdhgvpespkslldlirkveksk..........eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmv

ANFGQYRFVYSTVI
 .. || |.| ...
qsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 5-118 9.9e-33 108.9 In-house 131-234 (235) alignment 
Range on Protein: 5-118
Range on HMM: 131-234/235.0
QQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLRqrtsttrssvHESKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRMLLV
..|.|.....|.|||| ||..|.|.|.....||. .          .... ||.||| |||||||.... |... ...... ... ... .||.||. .|
ekrevkqlhytnWpdhgvpespkslldlirkveksk..........eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmv

ANFGQYRFVYSTVI
 .. || |.| ...
qsleqYiflykail
subfamily_PTPN6_pd Subfamily PTPN6 4-125 2.4e-32 107.2 In-house 183-301 (306) alignment 
Range on Protein: 4-125
Range on HMM: 183-301/306.0
KQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLRQRTSTTrssvheSKPPVLVHCTAGVGRTGVIILTDLMIACIQNN---KRINIHHALVRLRRQR
|..|.|.. .|..|||| || ||  .|.||..|.. .......      .. |..|||.||.|||| .|..|...  |...     |.|...   .|.||
keerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleea......eagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqr

MLLVANFGQYRFVYSTVIHYIKNSR
  ||    ||.||| .. .||....
sglvqteqqykfvykaikkyietkk
PTPc_DSPc_SM00012 8-118 1e-31 104.6 In-house 1-104 (105) alignment 
Range on Protein: 8-118
Range on HMM: 1-104/105.0
TVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLRQRTSTtrssvhesKPPVLVHCTAGVGRTGVIILTDLMIACIQNN-KRINIHHALVRLRRQRMLLVAN
||.|...|.|||| ||....|.||.|..|.. ..  ..        ..||.||| |||||||.... |...  .... |...|   . .||.||. .| .
tvkhyhytgwpdhgvPeesdsilellravkknknkses........skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqt

FGQYRFVYSTVI
. || |.|  ..
eeqylflyrall
subfamily_PTPN9_pd Subfamily PTPN9 3-124 2.5e-30 100.6 In-house 169-293 (297) alignment 
Range on Protein: 3-124
Range on HMM: 169-293/297.0
TKQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLRQR---TSTTRSSVHESKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQ
|...|.| | ||. |||. ||.. .|.|..|..| . .     . . ..  | |.||..|||.||.||||  |  |. .. ...   ... ... .|| |
teesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtq

RMLLVANFGQYRFVYSTVIHYIKNS
|   .    || | | .|. | ...
rafsiqtpeqyefcylavleyalel
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 4-122 1.2e-29 98.5 In-house 175-284 (305) alignment 
Range on Protein: 4-122
Range on HMM: 175-284/305.0
KQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLRQRtsttrssvhESKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRMLL
|..||| . |.|||||| ||. .||.|.....|.  ...         . . |.|||| |||||||| |  |...  ... . ... . | .||..|| .
kesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkk.........dkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkm

VANFGQYRFVYSTVIHYIK
| .  || |..  .  .|.
vqtldqYvflhdaldelit
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 5-123 1.5e-29 97.8 In-house 150-266 (270) alignment 
Range on Protein: 5-123
Range on HMM: 150-266/270.0
QQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLRQRTsTTRSSVHESKpPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRMLLV
..| . | ....|||| || .. | |.  . .. ||.    .... .... |.||||.|||||||..|..| .. .....|.... . . .||..|| ||
eerrlvHfwyntWpdhgvpreedsslstdqllkmlravr.rsekeldkae.PllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalv

ANFGQYRFVYSTVIHYIKN
    ||.|.| .|..|.. 
qhpeqyeflykavveyaer
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 3-122 4.6e-29 96.4 In-house 171-280 (288) alignment 
Range on Protein: 3-122
Range on HMM: 171-280/288.0
TKQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLRQRTsttrssvhesKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRML
.|..... . |.. |||| ||.. . .||.|.||.   |              |..|||.|||||||. |  | .|  ..... |..  .. .||.||.|
kkteleitqyqylaWpdhgvPeskapllellrqvkvanqad..........tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRal

LVANFGQYRFVYSTVIHYIK
|| .  || |.|..... |.
lvqtlkqYefiyevllslie
subfamily_Ptp69D_pd Subfamily Ptp69D 5-122 5.3e-29 96.3 In-house 180-287 (307) alignment 
Range on Protein: 5-122
Range on HMM: 180-287/307.0
QQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLRQRTsttrssvhesKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRMLLV
..| |   ..| |.|  ||. ... |....||..| .            . |..||| |||||.|...  |...  ........| .    ||.|| |||
dsrkvvqyhytgWkDskvPevargllklieqvrelykln..........rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllv

ANFGQYRFVYSTVIHYIK
 .. || |.|  .. |..
qsleqYvflyralldyss
0043147 (Phosphotyrosine protein) phosphatases II 3-114 6.4e-29 96.3 In-house 59-154 (172) alignment 
Range on Protein: 3-114
Range on HMM: 59-154/172.0
TKQQRTVYHVQFTDWPDHRVPdDPTSFLEFLDQVES--LRQRtsttrssvhesKPPVLVHCTAGVGRTGVIILTDLMIaciqnnKRINIHHALVRLRRQR
.. .|........ |||| || ..  .||||.....  ....           . ||||||.|||||||.... .||.      .......|.  .|..|
ellerlgiqylylpwpDhgvp.llellleflefidellalsp...........ggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekR

MLLVANFGQYRFVY
.  | |..||||.|
pgavqnpsqyrfly
subfamily_PTPRB_pd Subfamily PTPRB 4-124 7.4e-29 95.7 In-house 176-288 (293) alignment 
Range on Protein: 4-124
Range on HMM: 176-288/293.0
KQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLRQRTSttrssvheSKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRMLL
|..|.| . .|| |||| ||......|.|. .|..  ..|.        || |..||| |||||||. |  | ..  |...  ..|   ...||..|.||
keerkvrqyhftsWpdhgvPektktlldfvrtvreaiekta........skrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnll

VANFGQYRFVYSTVIHYIKNS
| .  || |....|.......
vqtekqYifihqcvldllrkk
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 4-123 1.8e-28 94.4 In-house 158-270 (274) alignment 
Range on Protein: 4-123
Range on HMM: 158-270/274.0
KQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVeslrqrtSTTRSSVHESKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRMLL
...|.|.|  .||||||..|||....|.....|       ...|.. ..   ||.|||.||.||||. | ... .  ..... ... .  . || .|  .
erersvkhywytdWPdhksPddantlldlvlev.......eesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGm

VANFGQYRFVYSTVIHYIKN
| .  ||.... ....| |.
vqtseqyelihralclylkr
0036282 (Phosphotyrosine protein) phosphatases II 4-114 2.2e-28 94.5 In-house 64-163 (174) alignment 
Range on Protein: 4-114
Range on HMM: 64-163/174.0
KQQRTVYHVQFTDWPDHRVPDDPTsFLEFLDQVESLRQRtsttrssvhESKPPVLVHCTAGVGRTGVIILTDLMIACIQnNKRINIHHALVRLRRQRMLL
   |........ |||| |||... .|||...||. ...          .. ||||||.|||||||.... .||. ..  .. ... . . .||.||.  
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealse.........dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgm

VANFGQYRFVY
| ...||||.|
vqtpsQyrfly
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 6-123 2.7e-28 94.0 In-house 177-285 (319) alignment 
Range on Protein: 6-123
Range on HMM: 177-285/319.0
QRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLRQRTsttrssvheSKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRMLLVA
 |.| | |.|.|||| ||.. || |..| ...  |..|         .. |. ||| |||||||  |  | |.  ....  .....   ||| || ..| 
tRevkhfqyteWpdhdvPekatslldllkrirksrekt.........qsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvq

NFGQYRFVYSTVIHYIKN
.  ||.|.| ....... 
rpeqYkfiyealleavea
0041856 (Phosphotyrosine protein) phosphatases II 2-123 6e-28 93.1 In-house 72-173 (182) alignment 
Range on Protein: 2-123
Range on HMM: 72-173/182.0
PTKQQRTVYHVQFTDWPDHRVPDdPTSFLEFLDQVESlrqrtsttrssvheSKPPVLVHCTAGVGRTGVIILTDLMIACiqnnkRINIHHALVRLRRQRM
|.. .|........ |||| ||| . ..|.|...|..              .. ||||||.|||||||.... .||. .     .... .|.  .|..|.
pellerlgiqylylpwpDhgvpd.ldelldfieevle..............eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsleeavklvrsrRp

LLVANFGQYRFVYSTVIHYIKN
  | .  ||.|..  . .....
gmvitpnqyfflqlallellll
0048076 (Phosphotyrosine protein) phosphatases II 4-119 7.3e-28 92.5 In-house 42-141 (145) alignment 
Range on Protein: 4-119
Range on HMM: 42-141/145.0
KQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLRQRtsttrssvhesKPPVLVHCTAGVGRTGVIILTDLMIAciqnnKRINIHHALVRLRRQRMLL
   |.........|||| |||..  .||||...|.....           . ||||||.|||||||.... .||.      .......|| ..|.||.  
llerlgiqylylpwpDhgvpdllellleflefieealke...........ggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpga

VANFGQYRFVYSTVIH
| |.||.||.|  . .
vpnpgqlrflyefele
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 3-123 8.1e-28 92.3 In-house 166-278 (281) alignment 
Range on Protein: 3-123
Range on HMM: 166-278/281.0
TKQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLRQRTSTtrssvheskPPVLVHCTAGVGRTGVIILTDLMIACI-QNNKRINIHHALVRLRRQRM
. ..|.| ....| |||| ||.... .||| ..|..|... .           |...|| |||||||. |  | ..  . .........  .  ||..|.
sgetreveqlaytaWPdhGvPattkellefrkevlkltekktk.........aplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkern

LLVANFGQYRFVYSTVIHYIKN
|.|    ||.||| .|......
lmvqtvvqyefvykavldaldk
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 4-123 9.4e-28 92.2 In-house 172-282 (318) alignment 
Range on Protein: 4-123
Range on HMM: 172-282/318.0
KQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLRQRTSTTrssvheskpPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRMLL
...|.|   ..|.|||. ||....|.|... ||..  |.....         |..|||.|||||||| |  | ..  |.... .....   .||.|| |.
eesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgag.........pivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlm

VANFGQYRFVYSTVIHYIKN
|    || |.| ... ... 
vqtedqyefiydvllealas
0051429 (Phosphotyrosine protein) phosphatases II 3-122 3.1e-27 91.3 In-house 116-226 (272) alignment 
Range on Protein: 3-122
Range on HMM: 116-226/272.0
TKQQRTVYHVQFTDWPDHRVPDDPtsFLEFLDQVESlrqrtsttrssvhesKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRIN--------IHHALV
... |.|.| ..|||||| ||...  .||.|... .               . ||||||.||..|||.... .|... .  .  ..        . .|. 
agearevmhlhytdwpdhgvpqea..llellellld...............ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeave

RLRRQRMLLVANFGQYRFVYSTVIHYIK
.||.||.  | . .||.|.|  ......
elraqrpgavqteeqylflyeallellr
subfamily_PTPN12_pd Subfamily PTPN12 4-123 4.3e-27 89.7 In-house 167-279 (290) alignment 
Range on Protein: 4-123
Range on HMM: 167-279/290.0
KQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLRQrtsttrssvhESKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKR---INIHHALVRLRRQR
|..|.||  ..|.|||| ||  ..| ||....|..|..          ... |..||| |||||||.||  |..   ....|    ..... ...||.||
kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..........sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqr

MLLVANFGQYRFVYSTVIHYIKN
  ||    ||..|| .|......
aalvqtkeqyelvykavaelvqk
subfamily_PTPN1_pd Subfamily PTPN1 3-122 1.5e-26 87.8 In-house 158-272 (290) alignment 
Range on Protein: 3-122
Range on HMM: 158-272/290.0
TKQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVeslrqRTSTtrsSVHESKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKR---INIHHALVRLRRQ
|.. |...|  .| |||  ||. |..||.|| .|     | |    |. . . |...||.||.||.| ..| | ... |....    ..|.. |. ||..
tqetreilhfhyttwpdfgvpespaaflkflfkv.....resG...slssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrky

RMLLVANFGQYRFVYSTVIHYIK
|. |.    | || | .... .|
rlGliqtadqlrfsylaileGak
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 4-122 5.1e-26 86.6 In-house 182-291 (298) alignment 
Range on Protein: 4-122
Range on HMM: 182-291/298.0
KQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESlRQRTSTTRssvheskpPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRMLL
...|.| ...|| |||. ||   || |..|..|.   |. .  .        ||.|.| |||||.|  |  | ..  ..... . ..... .||..|. .
ekerevrqlhftsWpdkgvpenatsvldllrkvra.sqqqagnk........pvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpga

VANFGQYRFVYSTVIHYIK
|    || |.|. |.....
vqteeqYvfiyeavleald
0048179 (Phosphotyrosine protein) phosphatases II 5-115 8.2e-26 85.8 In-house 45-139 (144) alignment 
Range on Protein: 5-115
Range on HMM: 45-139/144.0
QQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLrqrtsttrssvHESKPPVLVHCTAGVGRTGVIILTDLMIaciqnNKRINIHHALVRLRRQRMLLV
  |.........|||| |||... .||||. .|..           .|.. ||||||.|||||||.... .||.      .......|| ..|..|.  |
leregiqylhlpwpDhgvpdllellleflefieea...........leeggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgav

ANFGQYRFVYS
 |.||.||.. 
pnpgqlrfLle
0046846 (Phosphotyrosine protein) phosphatases II 10-123 1.1e-25 85.8 In-house 77-175 (176) alignment 
Range on Protein: 10-123
Range on HMM: 77-175/176.0
YHVQFTDWPDHRVPDDpTSFLEFLDQVESLRQRTsttrssvheskPPVLVHCTAGVGRTGVIILTDLMIAciqnNKRINIHHALVRLRRQRM-LLVANFG
.......|||| |||. . .||.|..... ...             |||||| ||.||||.... .|..     .| .....|| ..|.||.   | ...
iqylhlpwpDhgvpdl.elllellefirealkeg...........gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpe

QYRFVYSTVIHYIKN
||||.|  . ...|.
Qyrflyefellllkk
subfamily_PTPN23_pd Subfamily PTPN23 3-123 1.4e-25 84.7 In-house 167-282 (288) alignment 
Range on Protein: 3-123
Range on HMM: 167-282/288.0
TKQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLR---QRTSTTrssvheskpPVLVHCTAGVGRTGVIILTDLMIACIQN-NKRINIHHALVRLRR
... ..| |.|.| ||.. ||. | ..|.|||.|||     || | |         |..||| ||||||||. |    .. ... |  ..| . . |||.
adavksvshlqltsWpelGvPasPetllqfldevesayeavqrkskt.........PlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlre

QRMLLVANFGQYRFVYSTVIHYIKN
||   | .  |..|.|. |......
qRrfmvqekeqlkfsyeavleaarr
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 4-122 2.8e-25 84.1 In-house 174-285 (297) alignment 
Range on Protein: 4-122
Range on HMM: 174-285/297.0
KQQRTVYHVQFTDWPDHRVPD-DPTSFLefLDQVESLRQRTSTtrssVHESkpPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRML
|..| |   ||..|||. |.  | .| |  |. .. .|.  |.    . |.  |.||||.||||||||..  | ..| ....| ..|   . .||..|. 
karrvvkqyqfveWPdkaverkdsassl..lklisevrkdfsq....naeg..PllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpy

LVANFGQYRFVYSTVIHYIK
||    ||.||| .|. .. 
lvqtkeqykfvyvavleall
subfamily_PTPN13_pd Subfamily PTPN13 3-122 3.3e-25 83.9 In-house 162-270 (273) alignment 
Range on Protein: 3-122
Range on HMM: 162-270/273.0
TKQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESlrqrtsttrssVHESKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRML
... | | |..|..|||| ||  ....|.|. .| .           ..... |..|||.||.||.|..|  | ..  |...| ..... . .||.||  
sgesrevahlnfvkwPdhgvPssaaellqfvaevrr...........lqtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqg

LVANFGQYRFVYSTVIHYIK
.|    || ||| .... .|
vvqtkdqyifvykailevlk
0049260 (Phosphotyrosine protein) phosphatases II 9-114 4.1e-25 83.7 In-house 54-143 (152) alignment 
Range on Protein: 9-114
Range on HMM: 54-143/152.0
VYHVQFTDWPDHRVPDDPTSFLEFLDQVESLrqrtS----TtrssvheskpPVLVHCTAGVGRTGVIILTDLMIaciqnnKRINIHHALVRLRRQRMLLV
 ...... |||| |||..  .|..|. .| |                    ||||||.|||||||.... .||.      ..... .|. ..|..|.  |
yiqylhlpwpDhgvpdlsqlllflllfiekl....aldkgg..........pvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgav

ANFGQYRFVY
 |.||.||.|
pnpgqlrfly
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 4-122 4.9e-25 83.2 In-house 134-243 (250) alignment 
Range on Protein: 4-122
Range on HMM: 134-243/250.0
KQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLRQRTSTTrssvheskpPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRMLL
...|.| ...|. |||  ||.  |. ||.|..|.. .|.. ..         ||.|.|.|||||.|  |  | ..  ....| ..... . .||..|.  
aderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagna.........PvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrpha

VANFGQYRFVYSTVIHYIK
|    || |||. ......
vesleqyvfvyeiilkald
subfamily_PTPRK_pd Subfamily PTPRK 3-118 1.2e-24 81.7 In-house 169-274 (314) alignment 
Range on Protein: 3-118
Range on HMM: 169-274/314.0
TKQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLRQRtsttrssvheSKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRML
 ...|.| ..||. |||| ||   |..|... .|.. ..           .. ...|||.|| ||||. |  | ..  |.... .....|   || ... 
qeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee..........eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvn

LVANFGQYRFVYSTVI
.|    ||.|.|  ..
mveteeqykfiydvil
subfamily_PTPRA_pd Subfamily PTPRA 3-120 1.4e-24 81.6 In-house 187-294 (330) alignment 
Range on Protein: 3-120
Range on HMM: 187-294/330.0
TKQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLRQRTSttrssvheSkpPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRML
 |..| |  . || |||  || .|   |..| .|..|.|...        .  |. |||.|||||||  |  | ... .. .......... ||| ||  
ekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsa........g..pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpq

LVANFGQYRFVYSTVIHY
.|    || |.| .. .|
mvqtdeqyefiykvlley
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 4-119 1.4e-24 82.0 In-house 182-289 (319) alignment 
Range on Protein: 4-119
Range on HMM: 182-289/319.0
KQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLRQRTsttrssvhESKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRMLL
|..| .    |  |||. ||| |. .. ....|. |...         . . ...|||.|||||||| |  | ..  ....|...... .  ||.||  |
kdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltske........nhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntl

VANFGQYRFVYSTVIH
| .. || |.||... 
vqdlvqykfiysalle
subfamily_CG7180_pd Subfamily CG7180 5-121 1.9e-24 80.8 In-house 178-290 (296) alignment 
Range on Protein: 5-121
Range on HMM: 178-290/296.0
QQRTVYHVQFTDWPD-HRVPDDPTSFLEFLDQVESLRQRTsttrsSVHESKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRMLL
..|.| ..|.| |.  ..||   ....|.. .|...|...       .. . ||.|... |..|.|| .  |  .  ......... .|. .|||.|  |
etRivklfqlteWeledkvPlstnalielrrrvrlwrekv.....dedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqL

VANFGQYRFVYSTVIHYI
| |  .|...| .. ...
venveeYkyiYdvlleav
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 4-119 2.7e-24 81.1 In-house 146-253 (284) alignment 
Range on Protein: 4-119
Range on HMM: 146-253/284.0
KQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLRQRTsttrssvhESKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRMLL
|..|..    |  |||. ||| |. .. ....|. |...         . . ...|||.|||||||| |  | ..  ....|...... .  ||.||  |
kdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltske........nhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntl

VANFGQYRFVYSTVIH
| .. || |.||... 
vqdlvqykfiysalle
subfamily_PTPRG_pd Subfamily PTPRG 4-122 3e-24 80.2 In-house 180-288 (563) alignment 
Range on Protein: 4-122
Range on HMM: 180-288/563.0
KQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVeslrqrtsttRSSVHESKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRMLL
.....|.. ..|.|||| ||. ..  | |  .             . ..   |..||| |||||||. |  | ..  ||... .|... | ..| ||  |
dteklvrqyhytkWPdhgvPehslpvLifvkks..........saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnfl

VANFGQYRFVYSTVIHYIK
|..  || |.. ...  |.
vqteEqYiflhdalleaia
0044763 (Phosphotyrosine protein) phosphatases II 10-123 3.5e-24 80.8 In-house 76-173 (178) alignment 
Range on Protein: 10-123
Range on HMM: 76-173/178.0
YHVQFTDWPDHRVPDDPTSFLEFLDQVESLRqrtsttrssvHESKPPVLVHCTAGVGRTGVIILTDLMIACiqnnkRINIHHALVRLRRQRMlLVANFGQ
...... .||| ||| .  ||||.. .|...          .|.. ||||||.|||||.|.... .||. .     ......|. ..|..|.  | |.||
iqylhipipDhgvpdllehflefvefieeal..........dekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpgq

YRFVYSTVIHYIKN
.|..|    .. |.
lrqLyefelrllke
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 5-122 1e-23 78.2 In-house 170-277 (515) alignment 
Range on Protein: 5-122
Range on HMM: 170-277/515.0
QQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESlrqrtSTTRSSvHeskpPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRMLLV
. |||   .||.|||. || . .|.| .. .| .     .. . . |    |...||.||||||||.|  | ..| ... . ... . .  .|..|. ||
dsrtvtqfhfteWPdkGvpkhtssllklikevka.....dhgqyt.h....pliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylv

ANFGQYRFVYSTVIHYIK
    || |.| .|  ...
qtqeqyafiygavledll
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 4-122 1.5e-23 78.2 In-house 170-278 (315) alignment 
Range on Protein: 4-122
Range on HMM: 170-278/315.0
KQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESlrqrtsttrsSVHESKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRMLL
...|||   |||.|||. |. . .|.|... .| .          . .. . ..||||.||||||||.|  | ..| |.... ... . .  ||..|. |
eesrtvtqfqftewPdkGvdkqtssllklikevka..........dngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpyl

VANFGQYRFVYSTVIHYIK
|    .| |.| .|  ...
vqteeeyafiydavledll
0051082 (Phosphotyrosine protein) phosphatases II 5-115 2.2e-22 74.7 In-house 56-147 (151) alignment 
Range on Protein: 5-115
Range on HMM: 56-147/151.0
QQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESlrqrtsttrssvhESKPPVLVHCTAGVGRTGVIILTDLMIACiqnnkrINIHHALVRLRRQRMLLV
....|.|....||||. .|. . ..||||.....              .. ||||||.||.||||.... .||.        ...  ||  .|..|. .|
lgievlhipildwpdpglplsfdavleflellld.............kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvv

ANFGQYRFVYS
  . |..|.. 
qpnqqflfqlf
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 3-122 4.2e-21 69.9 In-house 170-280 (439) alignment 
Range on Protein: 3-122
Range on HMM: 170-280/439.0
TKQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLRQRtsttrssvhESKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRML
|...||| ..... |||. || . .  |.||  ..|  ..         |   ||.|||.||||||| ||  |. .  .. .....|.  .  ||.||  
tekertvlqfhyiawpdknvpaqashvldflrainsandk.........eeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkq

LVANFGQYRFVYSTVIHYIK
.| .. || |.| .|.  |.
mvqalcqyvfiynavlediv
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 6-118 6.9e-21 69.5 In-house 174-276 (315) alignment 
Range on Protein: 6-118
Range on HMM: 174-276/315.0
QRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLRQRTSttrssvheskPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRMLLVA
 |.|. ...| |||  ||   ......  .|   .. .            ...||| |||||||  |  | ..  .. .. |...... ..|..|. .|.
irevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv..........gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvq

NFGQYRFVYSTVI
   ||.|.|....
vaeqyqfiydall
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 6-121 3.8e-20 67.3 In-house 177-288 (325) alignment 
Range on Protein: 6-121
Range on HMM: 177-288/325.0
QRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLRQRTST-TRSSVheskpPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRMLLV
 |.|   |.  |.|  |.  |.... .|. |. . .|  . |..|      |.||||.|||||||| |    ..| . .. |..|   . .||..|  .|
trsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkast.....pilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmv

ANFGQYRFVYSTVIHYI
    || ..| ... ..
etvdqyiliyealveay
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 4-122 7.6e-20 65.9 In-house 161-296 (297) alignment 
Range on Protein: 4-122
Range on HMM: 161-296/297.0
KQQRTVYHVQFTDWPDHRVPDDPTSFLEF--------------LDQVE---SLRQRTSTTRSSVHESKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKR
...| | ||||  |||| || |      |              |  ||   ..      .  . .  . ..||||.|||||.||..|.| ..| ..... 
sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkri

INIHHALVRLRRQRMLLVANFGQYRFVYSTVIHYIK
 ..   |  || ||  ||  . |. ..|. |.. .|
pdvaailsilreqrarlvqtleqfellydavlkklk
0049772 (Phosphotyrosine protein) phosphatases II 6-122 8.5e-20 67.1 In-house 177-281 (314) alignment 
Range on Protein: 6-122
Range on HMM: 177-281/314.0
QRTVYHVQFTDWPDHRVPdDPTSFLEFLDQVESLrqRtsttrssvheSKPPVLVHCTAGVGRTGV-IILTDLMIACiqnnkRINIHHALVRLRRQRM---
.|.....  ...||. .| ..  |.|||. .|..  .           . ||||||.||.||||. ...  ||...     ..... || ..|..|.   
erlgikylripvpDgsap.lledfdeflefieea..d..........kggpvlvHCkaGkgRtgtfvvaaylmkll.....gvsleealedvrlkRpinp

--LLVANFGQYRFVYSTVIHYIK
   .. .. || |..  . .|.|
npgfieqleqyefilealleylk
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 3-123 1.8e-19 64.6 In-house 172-278 (312) alignment 
Range on Protein: 3-123
Range on HMM: 172-278/312.0
TKQQRTVYHVQFTDWPDHRVPDDPTSFLEFLdqveslrqrtsttrSSVHESKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRML
| |.  . | |.. |||| .||   . | .|              |.|.  | ||. ||.||||||| ..| . |||...  .. |.....| ||..|  
tgqesklnhyqwaswpdhgmpdscdtalrll..............savkkdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrar

LVANFGQYRFVYSTVIHYIKN
 |  | || ..  .|.... .
svrvfpqyvyalrcvleflys
subfamily_PTPRN_pd Subfamily PTPRN 3-121 3.5e-19 63.6 In-house 183-292 (297) alignment 
Range on Protein: 3-121
Range on HMM: 183-292/297.0
TKQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVEslrqRTSTTRSSvheskpPVLVHCTAGVGRTGVIILTDLMIACIQ-NNKRINIHHALVRLRRQRM
|.. |||    |  ||.. ||  . |.|||  .|.    ..   ||.      |..|||..|.||||| || ||... ..   |.|.|  .|  || || 
tsetrtvtqfhflswpeegvPasaksllefrrkvn....ksyrGrsc......pivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrp

LLVANFGQYRFVYSTVIHYI
 ||.   |..|....|.. .
glvktkdqfefaltavaeev
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 5-119 8.8e-19 62.2 In-house 130-234 (392) alignment 
Range on Protein: 5-119
Range on HMM: 130-234/392.0
QQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESlrQRTSTTrssvHeskpPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRMLLV
..|||   .||.|||. ||   .|.|.|. .|..  .  . |    |    |...||.||||||||.|  | ..|  .. . ...   .. .||.|  .|
dartvaqfhftewPdkdvpkhtssllkfikevka..dfGqyt....h....pliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymv

ANFGQYRFVYSTVIH
    || |.| .|. 
qtkeqyafiygavle
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 8-122 1.7e-18 61.5 In-house 216-345 (350) alignment 
Range on Protein: 8-122
Range on HMM: 216-345/350.0
TVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLRQRTSTTRSSVHESKPPVLVHCTAGVGRTGVIILTDLMIA------CIQNNK---------RINIHHA
 ||..|.  |.|  .  .| |.|. |.  . | .   .   .  .  .|.|||| |||||||...  | ..        ....          |  |.  
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

LVRLRRQRMLLVANFGQYRFVYSTVIHYIK
. .||.||. .| |  |. |.| .. .| .
vnelrkqrismvqnldqfifiYeallfyfa
subfamily_CG42327_pd Subfamily CG42327 45-122 3.4e-18 60.4 In-house 238-316 (319) alignment 
Range on Protein: 45-122
Range on HMM: 238-316/319.0
TTRSSVHESKPPVLVHCTAGVGRTGVIILTDLMIACIQNN-KRINIHHALVRLRRQRMLLVANFGQYRFVYSTVIHYIK
..||. .||. |. |||. ||||||..| .|. |  .... . ..| . .  .||.|   | .  || |.| ..  | |
ssrsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 4-123 2.3e-17 57.8 In-house 175-285 (290) alignment 
Range on Protein: 4-123
Range on HMM: 175-285/290.0
KQQRTVYHVQFTDWPDHR-VPDDPTSFLEFLDQVESLRQRtsttrssvheSKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRML
.....| . |.| |...  |..  |. | .  ...  |.|           . ...||| ..|||..| . ..  |   . .  |.. . | ..| |.. 
gakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkr..........gntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpg

LVANFGQYRFVYSTVIHYIKN
.|    ||..... |..|...
svqtvqqyqgifqivltylds
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 3-123 3.2e-17 57.3 In-house 164-279 (287) alignment 
Range on Protein: 3-123
Range on HMM: 164-279/287.0
TKQQRTVYHVQFTDWPDHRVPDDPTSFLEFldqVESLRQRTSTTRSSvHESKpPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRML
|.. | |  ... .|||. ..    ... |   | . .|.   .|..  |   |..||. .|.||.|... |  ..   ..  |...  ...||| .|  
trearvvkqldllswPdkvlaPtavglirf...vldvkqhielarda.sevG.PlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraa

LVANFGQYRFVYSTVIHYIKN
||    |.|..| ... | | 
lvqavvqlrllyealvtyykt
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 4-118 3.2e-17 57.5 In-house 130-236 (237) alignment 
Range on Protein: 4-118
Range on HMM: 130-236/237.0
KQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVeslrqrtSTTRSSVHESkPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRMLL
|. | ..  ||| |||. ||.  ...| |  ..             | ||  | ..||.|||||||.... | |.   ...| ..|.  .  .  .|  .
kevrlihqyqftswpdrgvpqqtaallrfrkni.......inrsphvses.gpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyi

VANFGQYRFVYSTVI
.    || |.. |..
iqtkdqyvfihqtil
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 4-123 6.8e-17 56.4 In-house 170-280 (287) alignment 
Range on Protein: 4-123
Range on HMM: 170-280/287.0
KQQRTVYHVQFTDWPDHR-VPDDPTSFLEFLDQVESLRQRTSTtrssvheskpPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRML
.....|   |.|.|.... |..  |..| . ... . |.|. |          ...|||...|||... .  .  |   ...  |..   | . | |.. 
gdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgnt..........sivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpg

LVANFGQYRFVYSTVIHYIKN
 |    ||.|..  |..|.. 
svqtveqykfindivleylds
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 7-122 8.3e-17 55.5 In-house 218-345 (349) alignment 
Range on Protein: 7-122
Range on HMM: 218-345/349.0
RTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLRQRTSTTRSSVHESKPPVLVHCTAGVGRTGVIILTDLMIA------------CIQNNKRINIHHALV
  .. .|. .|.|  .  .| |.|. |.  . |     .      .  ...||||.|| |||||..  ||...             .|. ..  |. .. 
yellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivn

RLRRQRMLLVANFGQYRFVYSTVIHYIK
 ||.||. .|.|. |. ..| ....|..
elrkqrismvqnlaqfiaiyealLkyfa
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 4-121 2.4e-16 54.3 In-house 185-289 (305) alignment 
Range on Protein: 4-121
Range on HMM: 185-289/305.0
KQQRTVYHVQFTDWPDHRVPDDPTSFLEFLdqveslrqrtsttrSSVHESKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVR-LRRQRML
.|. .| |.|.|.|||  ||    . ||.|              |..  || |..|||.||.|||| |.  . ..  | .||.      ||. || ||  
dqkmsvrhlqwtewpdrgvppckltslell..............sairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqraf

LVANFGQYRFVYSTVIHYI
 . |  || |..  .. |.
siqndvqylfihrvmlnyf
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 3-126 2.8e-16 54.1 In-house 182-292 (305) alignment 
Range on Protein: 3-126
Range on HMM: 182-292/305.0
TKQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQveslrqrtstTRSsvheSKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRIN-IHHALVRLRRQRM
 ...| | |  . ||||  ||   .. ||.| .          .|.    || |. |||.||.|||| ... . ..  . . . |.  .. |...| || 
gekarkvthyhwidwpdrgvpaadlailellek..........arp....skgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrn

LLVANFGQYRFVYSTVIHYIKNSRL
  .    || ||.  .. |... .|
nsiqtdaqylfvhqvilnyfrkkkl
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 5-121 3e-16 54.3 In-house 169-271 (288) alignment 
Range on Protein: 5-121
Range on HMM: 169-271/288.0
QQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVeslrqrtsttrS---SvheskpPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRM
..  | .. . .|.|. ||..  |.| .|. .                      |..||. ||||||| .||. ...  .. .  . |.. | .|| .|.
ekvivkilhlleWdddgvPenylsplrllevl...........kslqk......PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerf

LLVANFGQYRFVYSTVIHYI
  .    || .|.  | ...
kaiqtemqylyvhrcvleel
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 5-118 5.1e-16 53.6 In-house 134-237 (239) alignment 
Range on Protein: 5-118
Range on HMM: 134-237/239.0
QQRTVYHVQFTDWPDHRVPDDPTSFLefldqveSLRQRtsTTRSSVHESKPPVlVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRMLLV
..| ||. .|| |||. ||.  |. |        ||..   |. |.  ..| | .||.||||||| ... | |.   ...| ..|   .  .| .|  .|
eeryvyqyhftvwpdkgvpqyatavl.......glrrk..itkdslpgarpwv.ihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmv

ANFGQYRFVYSTVI
    || |.. .|.
qtseqyvfihlavl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 5-118 5.9e-16 53.4 In-house 135-238 (239) alignment 
Range on Protein: 5-118
Range on HMM: 135-238/239.0
QQRTVYHVQFTDWPDHRVPDDPTSFLefldqveSLRQRtsTTRSSVHESKPPVlVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRMLLV
..| ||. .|| |||. ||.  |. |        ||..   |. |.  ..| | .||.||||||| ... | |.   ...| ..|   .  .| .|  .|
eeryvyqyhftvwpdkgvpqyatavl.......glrrk..itkdslpgarpwv.ihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmv

ANFGQYRFVYSTVI
    || |.. .|.
qtseqyvfihlavl
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 4-122 4.8e-15 50.0 In-house 185-294 (301) alignment 
Range on Protein: 4-122
Range on HMM: 185-294/301.0
KQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLRQRTsttrssvheSKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRMLL
|. ..|  .| ||||.. |  .|   |. .|.|   .|.          .. ||.||| ..|.|.|| .  .. .   . .  ...     ..||...  
ksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqki.........gggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpga

VANFGQYRFVYSTVIHYIK
|    || ..|  .  |..
VtTLeqytsiydvidmylq
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 6-120 1.9e-14 48.1 In-house 180-281 (301) alignment 
Range on Protein: 6-120
Range on HMM: 180-281/301.0
QRTVYHVQFTDWPDHRVPDdptSFLEFLDQVESlrqrtsttrssVHESKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRMLLVA
 ||| | |...|.|. ||    |  |  | .|            | .|. |..|||.||.||.   | |. .   ......|.. .|| .|| .|   | 
trtvthyqysewtdrgvPk...shaelfdlmel...........vkksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvq

NFGQ-YRFVYSTVIHY
.  | |     ||   
tnsqlywmtlGtvyrl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 4-121 3.9e-14 47.4 In-house 173-277 (307) alignment 
Range on Protein: 4-121
Range on HMM: 173-277/307.0
KQQRTVYHVQFTDWPDHRVPDDPTSFLEFLdqveslrqrtsttrSSVHESKPPVLVHCTAGVGRTGVIILTDL-MIACIQNNKRINIHHALVRLRRQRML
.. ||. |.|...|||. ||.   . ...|              ..|.  . ||.|||.|||||.| |.   | .   |.     .... .  || ||  
qksrtiqhlqwenwpdrgvpqinltainll..............eavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhy

LVANFGQYRFVYSTVIHYI
 . .  || ...  ...| 
aiqteaqylylhrvlleyf
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 5-119 7.6e-14 45.9 In-house 87-192 (440) alignment 
Range on Protein: 5-119
Range on HMM: 87-192/440.0
QQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLRQRTsttrssvheSKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRMLLV
. ||. . ..  |||. ||      |.....|.  ....         .. |.||||.||.|||||||  | ..   . . .|.|   .  .| .|  .|
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqeka.........gngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmv

ANFGQYRFVYSTVIH
    || ||. .|..
qtpeqyafvheavle
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 9-123 1.1e-13 45.2 In-house 185-287 (302) alignment 
Range on Protein: 9-123
Range on HMM: 185-287/302.0
VYHVqfTDWPDHRVPDDPTSFLEFLDQVeslrqrtsttRSSVHESKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRMLLVANFG
||..  | |....||.  ..  .   .|            .  ... ....  . |.|| |...   . . ..|..|  ||.  .  .| ||   | .. 
vyvl..tnWkqkkvpvkyaeliktaakv..........fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslk

QYRFVYSTVIHYIKN
|| ..| ... |||.
Qyvslyialllyikk
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 48-121 1.8e-13 45.1 In-house 186-259 (267) alignment 
Range on Protein: 48-121
Range on HMM: 186-259/267.0
SSVHESKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRMLLVANFGQYRFVYSTVIHYI
  . .  .|..|.|..||||.|  .  | ..  ....   .|.. | ..| ||. ||    .| ... .. .| 
nqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeya
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 9-118 2.3e-13 44.7 In-house 164-263 (283) alignment 
Range on Protein: 9-118
Range on HMM: 164-263/283.0
VYHVQFTDWpdhrvpddpTSFLEfLDQVESLRQRTSTTRSSVHESKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRMLLVANFG
. | |. ||         ... |    ..|| .         .. | |..|||..|.|||.| |     .  .. .  ...   .  .| ||| .| . .
lahyqvidW.........leyge.qaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtld

QYRFVYSTVI
||..|.  |.
qyklvhelvl
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 9-121 5e-12 40.4 In-house 169-270 (285) alignment 
Range on Protein: 9-121
Range on HMM: 169-270/285.0
VYHVQFTDWPDHRVPDDPTSFLEFLDQVESlrqrtsttrssVHESKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRMLLVANFG
. |||   |||.  |.|   ..|.   |.            |   . |. |||.||||||  ..  |     | .|  |..   .  .|  |.  | .. 
mnhvqvpwwpdqlapedarpmielykwvkk...........vnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshm

QYRFVYSTVIHYI
|. |.|  .. |.
qflflyvvlmeyf
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 6-123 7.7e-12 39.4 In-house 182-285 (290) alignment 
Range on Protein: 6-123
Range on HMM: 182-285/290.0
QRTVYHVQFTDWPDHRVPDdptSFLEFLDQVESLRQRTSttrssvheskpPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRMLLVA
.  ..|..   |||. |.    | | .|  . .||. .            || |||.||.|||| ..  .  . .. . | ...      ||. |.  | 
ehklkhlkikswpdksval...stlallrtlrilrkasG...........pvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvq

NFGQYRFVYSTVIHYIKN
   ||  .   .... |.
vdiqylalveilldlGkd
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 4-106 9.4e-12 39.0 In-house 185-273 (302) alignment 
Range on Protein: 4-106
Range on HMM: 185-273/302.0
KQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLRQRtsttrssvheskppVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRMLL
|...||  ..|. ||||  |... . |. |   || ..               |||||.||||||| ..     |   ...|  .. . .. .|. |   
kvkktvdilafsawpdhGapkeaytaldilkfcesykkn..............vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGa

VAN
| .
vqd
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 4-121 1.4e-11 39.1 In-house 155-259 (290) alignment 
Range on Protein: 4-121
Range on HMM: 155-259/290.0
KQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVEslRqrtsttrssvheSKPPVLVHCTAGVGRTGVIILTDLMIACIQ-NNKRINIHHALVRLRRQRML
... || | .. .| .  |..|. ..|. ...|.               || ||.|||. |. |  ..   .|    |   .. .... .|  ||.|| |
eeeftvtHsllkgWnklnvqedtktllsliqkvk..a............sktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqral

LVANFGQYRFVYSTVIHYI
.. .  .. ||   .. ..
aitsalelafvdagivlla
0038934 (Phosphotyrosine protein) phosphatases II 15-114 3.4e-11 38.6 In-house 85-170 (194) alignment 
Range on Protein: 15-114
Range on HMM: 85-170/194.0
TDWPDHRVPDDPTSFLEFLDQVESLRQRTSttrssvhesKPPVLVHCTAGVGRTGVIILTDLMIACiqnnkRINIHHALVRLRRQRMLLVANFGQYRFVY
  .||. .. .    |.||| |.   .. .         .  |.|||.||.||||...   |.  .     ... . |. ..|. |   . | .... ..
lpfpddgtvPsleillrfldlvdeflnedp.........ggvvaVHCkaGlgRtGtlvaaYLiyrl.....gmsaeeAialfrekRpgaipnqdyleall
subfamily_ptpA1_pd Subfamily ptpA1 6-79 4.3e-11 37.2 In-house 185-254 (418) alignment 
Range on Protein: 6-79
Range on HMM: 185-254/418.0
QRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESlRQrtSTTRSSVhESKPPVLVHCTAGVGRTGVIILTDLMIA
 | . . |.  |||| .||    | ..|  .   ||       |  . . |..|||.||||||| .  . .|. 
trditqyqyegwpdhnipdhtqpfrqllhsitn.rq..nqiipss.drnvpiivhcsagvgrtgtfctavimmk
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 6-115 2.8e-10 34.7 In-house 93-197 (198) alignment 
Range on Protein: 6-115
Range on HMM: 93-197/198.0
QRTVYHVQFTDWPDHRVPDDpTSFLEFLdqvESLRQrtsTTRSSVHESKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKR--INIHHALVRLRRQRMLL
 | . | ||| | ..  |.  . |. |.    . |.    ..    |   ||.|||. | | |||..  |. .   .. |   ...     |||. |  .
treishyqftswkekttpnv.alfvgfv...vasre...vskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgi

VANFGQYRFVYS
.. . .| |.| 
isslqhynfiyq
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 6-115 2.9e-10 34.7 In-house 94-198 (199) alignment 
Range on Protein: 6-115
Range on HMM: 94-198/199.0
QRTVYHVQFTDWPDHRVPDDpTSFLEFLdqvESLRQrtsTTRSSVHESKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKR--INIHHALVRLRRQRMLL
 | . | ||| | ..  |.  . |. |.    . |.    ..    |   ||.|||. | | |||..  |. .   .. |   ...     |||. |  .
treishyqftswkekttpnv.alfvgfv...vasre...vskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgi

VANFGQYRFVYS
.. . .| |.| 
isslqhynfiyq
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 59-122 1.5e-09 32.0 In-house 2-65 (69) alignment 
Range on Protein: 59-122
Range on HMM: 2-65/69.0
VHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRMLLVANFGQYRFVYSTVIHYIK
|||..| ||||  |   . .| |. .| ..|   .  .|. | ..| |  .| |.. ...  .|
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealk
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 13-122 1.8e-09 31.6 In-house 233-339 (347) alignment 
Range on Protein: 13-122
Range on HMM: 233-339/347.0
QFTDWPDHRVPDDPTSFLEFldqVESLRQRTSTTRSSVHESKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRMLLVANFGQYRF
. | || .. |||    | .   | .  . .||.  .  | ..||.| |  |. |.  ..|| ..|  . . |  .    . ..| ||  . .    | .
ncttwpwkkypddekkvlal...vrapvkesstslianleklapvvvmcdlgldrsatvvltsiiieqvldgktpdcddlfkkmrdqragvftmsifyty

VYSTVIHYIK
   . . |.|
airaalfylk
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 58-122 2.1e-09 31.6 In-house 2-66 (69) alignment 
Range on Protein: 58-122
Range on HMM: 2-66/69.0
LVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRMLLVANFGQYRFVYSTVIHYIK
.|||..| |||| .|   . .| |. .| ..|   .  .|. | ..| |  .| |.. ...  .|
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealk
subfamily_eak_pd Subfamily eak 55-123 4e-09 30.3 In-house 234-307 (332) alignment 
Range on Protein: 55-123
Range on HMM: 234-307/332.0
PP---VLVHCTAGVGRTGVIILTDLMIACIQNNKR--INIHHALVRLRRQRMLLVANFGQYRFVYSTVIHYIKN
||    .. .. |  |.|| .. ||.|  |.|.|.    . . ... . .|.  |    |. |.|  |..|...
ppsfapiiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllr
PTPc_motif_SM00404 6-110 1e-08 30.1 In-house 46-133 (140) alignment 
Range on Protein: 6-110
Range on HMM: 46-133/140.0
QRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVeslrqrtsttrssvHESKPPVLVHCTAGVGRTGVIILTDLMiacIQNNKRINIHHALVRLRRQRMLLVA
.... ...  |     . ..  . |.|....              ....  |||||.||| |.. .|.  ||    ...  ..    .|. ||...   .
gfqilqiplddnekdklskyldkvldfiena..............ekkggkvlVHCqaGvSRSatliiaYlm...ryrqlslaeayefvkerRpiispnl

NFGQY
|| . 
nfvrq
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 8-122 1.1e-08 29.0 In-house 171-280 (303) alignment 
Range on Protein: 8-122
Range on HMM: 171-280/303.0
TVYHV-QFTDWPDHRVPDD-PTSFLEFLDQVESLRQRTSttrssvhESKPPVLVhCTAGVGRTGVIILTDLMIACIQN-NKRINIHHALVRLRRQRMLLV
.  || .. .||   .| |    |.  . |..|. .. |       .|.|.| .   .|.||.| . | .     ... .  ... . |  .|  |.  |
sflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkys.......dstptvym.slsgcgragtfalfetahlslhseqasldlvkclenvrngrlhav

ANFGQYRFVYSTVIHYIK
 |. |. .||. .  .. 
qnlsqfsvvytllaehvl
DSPc Dual specificity phosphatase, catalytic domain 48-111 1.1e-08 30.0 Pfam-A 67-125 (133) alignment 
Range on Protein: 48-111
Range on HMM: 67-125/133.0
SSVHESKPPVLVHCTAGVGRTGVIILTDLMiaciqNNKRINIHHALVRLRRQRMLLVANFGQYR
.......  |||||.||. |.. .|.  ||     . |.... .|.  ....|  .. |.|. |
ekaeqkgkkvlVHCqaGisRSatliiaYlm.....ktknlslneAyefvkerrskispnagflr
DSPc Dual specificity phosphatase, catalytic domain 48-111 1.1e-08 30.0 In-house 67-125 (133) alignment 
Range on Protein: 48-111
Range on HMM: 67-125/133.0
SSVHESKPPVLVHCTAGVGRTGVIILTDLMiaciqNNKRINIHHALVRLRRQRMLLVANFGQYR
.......  |||||.||. |.. .|.  ||     . |.... .|.  ....|  .. |.|. |
ekaeqkgkkvlVHCqaGisRSatliiaYlm.....ktknlslneAyefvkerrskispnagflr
PTEN_1 53-112 1.2e-08 30.0 In-house 129-184 (196) alignment 
Range on Protein: 53-112
Range on HMM: 129-184/196.0
SKPPVLVHCTAGVGRTGVIILTDLMIACIqnnkrINIHHALVRLRRQRM-LLVANFGQYRF
..  |||||.||.||.|...   || .        . . || ..|..|.   . .. | |.
ngnvVlVHCkaGlgRsGtvvaayLmykgk.....ltadeAlelvrekRppgapnspsqerl
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 9-120 1.4e-08 28.6 In-house 192-289 (310) alignment 
Range on Protein: 9-120
Range on HMM: 192-289/310.0
VYHVQFTDWPDHRVPDDptsflefldQVESLRQRTSTtrsSVheSKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRMLLVANFG
|  ... .|||  |||.         .. .. ||  .    |   . |..|||.||..|..|..  .| |  ... .......    |...|.  . .  
vslikwpnwpdrgvpde.........kchtvpqrlla...qv..rhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtel

QYRFVYSTVIHY
|| ..    | .
qyliidrvriif
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 6-118 2.7e-08 27.8 In-house 166-266 (281) alignment 
Range on Protein: 6-118
Range on HMM: 166-266/281.0
QRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVeslRQRtsttrssvheSKPPVlVHCTAGVGRTGVIILTDLMIACIQNNKRI-NIHHALVRLRR-QRMLL
 | . |  . .||| .||.    .|. | ..   | |          | ||| .||.|||||.| ..  .. .  |..   . .|.. . .||   |   
trlithwlwkewpdwqvpessevmlkilrki...rar..........stppv.ihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraas

VANFGQYRFVYSTVI
|  . || ...  ..
vqtlqqymliwkvll
subfamily_PTEN_pd Subfamily PTEN 54-114 6.6e-08 27.7 In-house 114-173 (184) alignment 
Range on Protein: 54-114
Range on HMM: 114-173/184.0
KPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRiNIHHALVRLRRQRMLLVANFGQYRFVY
|  | ||| || |||||.| . |. ... .... .. .   . | .    |    | |.|.
knvvvvHCkaGkGRtGvlivayllkslllekae.ealelfaeaRtknkkgvtiPsqrRYve
subfamily_PTPDC1_pd Subfamily PTPDC1 48-116 7.7e-08 27.0 In-house 110-171 (182) alignment 
Range on Protein: 48-116
Range on HMM: 110-171/182.0
SSVHESkpPVLVHCTAGVGRTGVIILTDLMIAciqnnKRINIHHALVRLRRQRMLLVANFGQYRFVYST
....|    | ||| || |||||.| . |. |     ||.. ..|.  .| .|   .   .| ..|   
falqeg..kvavhChaGlGrtGvliacylvya.....krltaekaiklvrskrpksiqtreqvelvkef
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 4-119 2.2e-07 25.2 In-house 113-219 (255) alignment 
Range on Protein: 4-119
Range on HMM: 113-219/255.0
KQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQveslrqrtsttrssVHESKpPVLVHCTAGVGRTGVIILTDL----MIACIQNNKRINIHH--ALVRLR
|. .|| | ... |...  |...   |. |                |..|| .|.|||..|.||.   .|..|    ||  ... . ... .   |  ||
kkthtvkhysykGWieknaPelareilnilkv..............vrdsk.svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelr

RQRMLLVANFGQYRFVYSTVIH
 .|   . .  |  |   .|. 
skrkraihtPlqlafsilmvld
subfamily_DSP19_pd Subfamily DSP19 51-109 6.4e-07 23.8 In-house 86-139 (152) alignment 
Range on Protein: 51-109
Range on HMM: 86-139/152.0
HESKPPVLVHCTAGVGRTGVIILTDLMiaciqNNKRINIHHALVRLRRQRMLLVANFGQ
....  ||||| ||| |.  .... ||     .........||  .| .|  .  | | 
rskdgavlvHCnAGvSRsasvviaylm.....kkeelsleealelvrearpcikPneGF
subfamily_egg_pd Subfamily egg 53-122 8e-07 23.0 In-house 200-271 (307) alignment 
Range on Protein: 53-122
Range on HMM: 200-271/307.0
SKPPVLVHCTAGVGRTGVIILTDLMIACIQ--NNKRINIHHALVRLRRQRMLLVANFGQYRFVYSTVIHYIK
   ||.|..  || ......  .. .  .      .  . .| | ||..| | |    .| |||  |. ...
lskpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffr
Y_phosphatase3 Tyrosine phosphatase family 40-79 2.1e-06 22.8 Pfam-A 110-149 (164) alignment 
Range on Protein: 40-79
Range on HMM: 110-149/164.0
RQRTSTTRSSVHESKPPVLVHCTAGVGRTGVIILTDLMIA
... ..  . . |.. |||.|||||  ||||..   | ..
kkayrkvlealaeeegpvlfHCtaGKDRTGvvaalllsll
subfamily_DSP3_pd Subfamily DSP3 48-103 2.9e-06 21.0 In-house 91-141 (162) alignment 
Range on Protein: 48-103
Range on HMM: 91-141/162.0
SSVHESKPPVLVHCTAGVGRTGVIILTDLMIAciqnnKRINIHHALVRLRRQRMLL
.......  |||||..|| |  ...|  |||      .......|. . |..|..|
ealsqkegkvlvhcvvGvsRsatlvlayLmir.....rkmtlveairtvrkkReil
subfamily_DSP1_pd Subfamily DSP1 49-108 5.2e-06 20.6 In-house 90-144 (163) alignment 
Range on Protein: 49-108
Range on HMM: 90-144/163.0
SVHESKPPVLVHCTAGVGRTGVIILTDLMiaciqNNKRINIHHALVRLRRQRMLLVANFG
.|....  ||.|| ||. |   ..|  ||     ..||.... |    ...| .   |.|
evkkknGkvlihCqaGisRsstlclaylm.....ktkrvsleeafdfvkqrRsiisPnag
subfamily_DSP14_pd Subfamily DSP14 47-111 8.3e-06 19.8 In-house 76-135 (157) alignment 
Range on Protein: 47-111
Range on HMM: 76-135/157.0
RSSVHESKPPVLVHCTAGVGRTGVIILTDLMiaciqNNKRINIHHALVRLRRQRMLLVANFGQYR
  .|....  .||||.||| |   . |  ||     . .......|   .. .| ..  | | ..
ieevkkkggktlvhCvaGvSRSAslclaylm.....kyeklsLreayklvksaRpiirPNvGFwk
subfamily_DSP12_pd Subfamily DSP12 30-104 9.6e-06 20.1 In-house 65-127 (155) alignment 
Range on Protein: 30-104
Range on HMM: 65-127/155.0
LEFLDQVESLRQRTS-TtrssvhesKPPVLVHCTAGVGRTGVIILTDLMiaciqNNKRINIHHALVRLRRQRMLLV
|..||.. .  . .  .        .  |||||.||| |   |..  ||      ........||  .....    
LshldeavdFieealee........egavlvHCqagvSRSvtiviAYlm.....kkeklslekAlklvkekkpeie