Gene PTPN3 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN3
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP076_AA protein Get Run
NvecP076_AA_603-872 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN3_pd Subfamily PTPN3 599-876 1.4e-139 458.7 In-house 2-279 (280) alignment 
Range on Protein: 599-876
Range on HMM: 2-279/280.0
KVSIEQLRENLESGDLLVYFQELYRKKPGMAMDDARKPENLPKNRYRDILPYDETRVKLFKGS-DYINANFVNMEVPSHGIVLRYIAAQGPLEKTCGDFW
. |. .|.|.||||..|..|..|||||||.|.. |||||||.|||||||||||.||||| ... ||||||.||||.||.|.| ||||.||||.||. |||
resllllkeglesGavlaqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfW

QMIWEQESTLVIMLTTTMERGRVKCHQYWPEGEDTWTFGNLEVVCNKIrDFSPSYVYREMYVTDTTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSV
||.|||.|.|..||||..||||||||||||| ||....|...|.|.|  | . |||.||....|..| ..| |.||||||||||.||||..||||||..|
qmvweqksslivmlttlverGrvkChqyWPetedeleygefsvkceke.detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefverv

RHYREGTSTPAVVHCSAGVGRSGVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLKAYDDEV
|..|.|...| |||||||.||.|||...|||. .|| |||||||..||.|||||..|.||..|. |||||.||.|.. .
rklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvyeeil
0050432 (Phosphotyrosine protein) phosphatases II 604-872 2.6e-89 294.9 In-house 34-299 (308) alignment 
Range on Protein: 604-872
Range on HMM: 34-299/308.0
QLRENLESGDLLVYFQELYRKKPGMAMDDARKPENLPKNRYRDILPYDETRVKLFKGSDYINANFVNMEVpsHGIVLRYIAAQGPLEKTCGDFWQMIWEQ
.| . |..| |  .|.||...|| . .. |..||| .||||.|||||| .|||| .|||||||..|.. .  ...  ..||.||||..|..|||.|.|||
llekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgys..sklprkfIatqgPlpntvedFwrmvweq

ESTLVIMLTTTMERGRVKCHQYWPEG--EDTWTFGNLEVVCNKIRDfSPSYVYREMYVTDTTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYR
......|||...|.||.||.||||.   ......|.. | . ..    ..|..|....|.. .  ||.. ...|..||||.||......|.|.. ||...
nvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl

egTSTPAVVHCSAGVGRSGVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLKAY
   . | ||||||||||.|..  ..... ..|    | ..|.|...| ||   .||| |.||...| |. .
..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleyl
0051299 (Phosphotyrosine protein) phosphatases II 614-870 1.6e-85 282.4 In-house 25-284 (288) alignment 
Range on Protein: 614-870
Range on HMM: 25-284/288.0
LLVYFQELYRKKPGMAMDDARKPENLPKNRYRDILPYDETRVKLF-----KGSDYINANFVnmevPSHGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLV
||  |.||....| . .  |..||||.||||.|||||| .||||       |||||||...    . . .  ..||.||||..|..|||.|.|||.....
lleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyi....dgynlkrkfIatqgPlpntvedFWrmvweqnvrvI

IMLTTTMERGRVKCHQYWPEgEDTWTFGNLEVVCNKIRDfSPSYVYREMYVTDT----TTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREGT
.|||...|.||.||.||||. ....|.|.. | . ..    ..|..|...||..     .  || .....|..||||.|||.....|.|.. ||.... .
vmltklvelgrekcaqYwpl.ggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasg

STPAVVHCSAGVGRSGVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLK
. | ||||||||||.|..  ..... ..|  . | .||.|.|.| ||  ..||| |..||.|| | 
ggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealle
0040438 (Phosphotyrosine protein) phosphatases II 614-871 4.8e-84 277.6 In-house 20-275 (317) alignment 
Range on Protein: 614-871
Range on HMM: 20-275/317.0
LLVYFQELYRKKPGmAMDDARKPENLPKNRYRDILPYDETRVKLFK-----GSDYINANFVnmevPSHGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLV
||  |..|.. |.   .. |..||| .||||.|||||| .||||       .||||||..|    . . .  ..||.||||..|..|||.|.||| .|..
lleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyv....dgpnlkrkfIatqgPlpntvedFwrmvweqgvtvi

IMLTTTMERGRVKCHQYWPEgEDTWTFGNLEVVCNKIRDfSPSYVYREMYVTDTTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREGTSTPA
.|||...|.||.||.||||. ..|.|.|.. | . ..    .....|.. |.|. .  || . ...|..||||.||.. ...|.|.. ||...|. ..| 
vmLteleelgrekcaqYwpl.getltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpv

VVHCSAGVGRSGVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLKA
.|||||||||.|..  ..... ..|  . | . | |...| ||.  .|||.|. |...| |. 
lVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalley
0036941 (Phosphotyrosine protein) phosphatases II 612-872 1.1e-83 276.2 In-house 13-277 (297) alignment 
Range on Protein: 612-872
Range on HMM: 13-277/297.0
GDLLVYFQELYRKKPGMAMDDARKPENLPKNRYRDILPYDETRVKLfKGS--DYINANFVnmevPSHGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVI
  || .|.||.. .. . .. |..||||.||||.|||||| ||||| ...  |||||..|    . ...  ..||.||||..|..|||.|.||| .| ..
alllkefeellpllllgslsvallpenleknRykdilpydhtRVkl.ddegsdYinAsyv....dgydlkrkfIatqgPlpntvedFWrmvweqnvtvIv

MLTTTMERGRVKCHQYWPEG-EDTWTFGNLEVVCNKIRDF-SPSYVYREMYVTDTTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREG--TS
|||. .|.||.||.||||.  ....|.|.. | . ..  . ...|..|.. |||| .  ||.. ...|. ||||.||......|.|.. ||....    .
mltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsg

TPAVVHCSAGVGRSGVLMFIETAFGMIE---GAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLKAY
.| .|||||||||||..  ..... ..|     . | .||.|. .|.||   .||..|..|..|| |. .
gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
0046845 (Phosphotyrosine protein) phosphatases II 618-871 2e-83 275.4 In-house 6-273 (284) alignment 
Range on Protein: 618-871
Range on HMM: 6-273/284.0
FQELYRKKPGM--AMDDARKPENLPKNRYRDILPYDETRVKLF------KGSDYINANFVNME-VPSHGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLV
|.||.. .. .   .. |..|||| ||||.|||||| .||||       ..||||||..|..  .. . |  ..||.||||..|..|||.|.|||.....
feellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvI

IMLTTTMERGRVKCHQYWPEGEDTWTFGNLEVVCNKIRDfSPSYVYREMYVTDTT-TLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYRE--GTS
.|||...|.||.||.||||. ....|.|.. | . ..    ..|..|....|..  |  || .....|..||||.||....|.|||.. ||...|  ...
VmltelvengrekcaqYwplegevltygdftvtllseev.kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgg

TPAVVHCSAGVGRSGVLMFIETAFGMIEGAE---PVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLKA
 | ||||||||||.|..  ..... ..|  .    | .||.|.|.|.||   .||. |..||.|| | .
gpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealley
0045450 (Phosphotyrosine protein) phosphatases II 617-870 5.6e-82 271.2 In-house 32-302 (307) alignment 
Range on Protein: 617-870
Range on HMM: 32-302/307.0
YFQELYRKKP--GMAMDDARKPENLPKNRYRDILPYDETRVKLF------KGSDYINANFVNMEV----PSHGIVLRYIAAQGPLEKTCGDFWQMIWEQE
 |..|.. ..   . .. |..||| .||||.|||||| |||||       ..||||||..|.. .    ... . ...||.||||..|. |||.|.||| 
efekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqg

STLVIMLTTTMERGRVKCHQYWPEGEDTWTFGNLEVVCNKIRDfSPSYVYREMYVTDT-TTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREG
.|...|||...|.||.||.||||. ....|.||. | . ..    ..|..| . |||.  |  || .....|..||||.||..  ..|.|.. ||...| 
vtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkalee

--TSTPAVVHCSAGVGRSGVLMFIETAFGMIEGAEP---VYPLELVRRMRDQRGSLIQTPGQFLFVCEATLK
   ..| .|||||||||.|... . ..  ..|  .    | .|| |...|.||.  .|.|.|. |..|| |.
lpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
subfamily_PTPRD_pd Subfamily PTPRD 623-871 1.6e-80 266.3 In-house 33-280 (564) alignment 
Range on Protein: 623-871
Range on HMM: 33-280/564.0
RKKPGMAMDDARKPENLPKNRYRDILPYDETRVKL-----FKGSDYINANFVNmevpSHGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMER
.... . .. |.||.| .|||| .|..||..||.|      .|||||||.|..    ..     |||.||||..|. |||.|.|||.|. ..||| . |.
eegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfid....gyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEk

GRVKCHQYWPEGEdTWTFGNLEVVCNKIRDFSpSYVYREMYVTDTTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREGTSTPAVVHCSAGVG
|.||||.|||| . | |.|.|.|  ..  ...  |. |.. ......  || . | .. .||||.||. ||..|.... ||...| .. | |||||||||
gkvkchkYWPekg.tetygeltVtleeeeela.dyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVG

RSGVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLKA
|.|. . |.     |.  . |   . |...| ||  ..||. |. |. || |.|
RTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailea
subfamily_PTPN13_pd Subfamily PTPN13 603-871 2.5e-80 264.6 In-house 2-268 (273) alignment 
Range on Protein: 603-871
Range on HMM: 2-268/273.0
EQLRENLESGDLLVYFQELYRKKPGMAMDDARKPENLPKNRYRDILPYDETRVKLFKGSDYINANFVNMEVpsHGIVLRYIAAQGPLEKTCGDFWQMIWE
 .|...|....    |.||   ||    . ..| ||  |||||..|||||||||| . . ||||......|       .|||.|||| .|. |||||.||
aalqkkldqqqPaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdeggyinaslikvpv..gkdeyeyiacqGPlPetvkdfwqmvwe

QESTLVIMLTTTMERGRVKCHQYWPEGED-TWTFGN-LEVVCNKIRDFSpSYVYREMYVTDTTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHY
|......|.|.  |.|.||||.|||| .. . .  | |||   |. . . ..| |.. |.|. . .|| . .|.. .||||.||  |...|.||  ||. 
qkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkld.gfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrl

REgTSTPAVVHCSAGVGRSGVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLKA
..  ..| |||||||.||||.|. |....|.||  ...   |.||..|.|| ...||  |..|| .|.|..
qt.dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailev
0047943 (Phosphotyrosine protein) phosphatases II 610-869 3.4e-80 264.7 In-house 10-269 (273) alignment 
Range on Protein: 610-869
Range on HMM: 10-269/273.0
ESGDLLVYFQELYRKKPGMAMDDARKPENLPKNRYRDILPYDETRVKL-FKGSDYINANFVnmevPSHGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLV
 .. ||  |..|.. || . .  |..|||. ||||.|||||| .||||  .|||||||..|    . . .  ..||.||||..|..|||.|.||| ....
gltllleefelllslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyv....dgynlkrkfiatqgPlpntvedfwrmvweqnvrvi

IMLTTTMERGRVKCHQYWPEGED--TWTFGNLEVVCNKIRDfSPSYVYREMYVTDTTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREG--T
.|||...|.||.||.||||. ..  ..|.|.. | . ..    ..|. |....|.. |  ||......|. ||||.||.. ...|||.. ||...|    
VmLtelvelgrekcaqYwpleggelsltygkftvtllseet.kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealps

STPAVVHCSAGVGRSGVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATL
..| ||||||||||.|..  ..... ..|    | .||.|...|.||   .||| |..|..|| |
ngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyeall
0043336 (Phosphotyrosine protein) phosphatases II 614-869 4e-79 261.3 In-house 22-274 (278) alignment 
Range on Protein: 614-869
Range on HMM: 22-274/278.0
LLVYFQELYRKKPgMAMDDARKPENLPKNRYRDILPYDETRVKLFK-----GSDYINANFVnmevPSHGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLV
||  |.||.. |. . .. |..||| .||||.|||||| .||||       .||||||..|    . . .  ..||.||||..|..|||.|.||. .| .
lllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyv....dgynvprkfiatqgPlpetvedFwrmvwelgvtti

IMLTTTMERGRVKCHQYWPegEDTWTFGNLEVVCNKIRDfSPSYVYREMYVTDTTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREGTSTPA
.|||. .|.|||||.||||  ....|.|.. | . |.    . |. | . ||.. .  || . ...||.||||.||.. ...|.|.. ||...|  ..| 
vmLtelvelgrvkcaqYwp..ggsltygdftvtllkeeh.lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpv

VVHCSAGVGRSGVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATL
.|||||||||.|... ..... ..|    | ..| |...| ||.. .||| |. |..|| |
lVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall
DSPc_SM00195 617-871 1.5e-77 255.8 In-house 5-261 (263) alignment 
Range on Protein: 617-871
Range on HMM: 5-261/263.0
YFQELYRKKPGMAMDDARKPENLPKNRYRDILPYDETRVKLFKG-----SDYINANFVNMEvpshGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIML
.|..| ....   ...|.|..|  ||||..|||||.||||| |      |||||||.....        .|||.||||..|. |||.|.||.......||
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga....nkkkkyIatQgPlpstvedFWrmvweekvkiivml

TTTMERGRVKCHQYWPEG-EDTWTFGNLEVVCNKIRDFSPSYVYREMYVTDTTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREGTSTPAVV
|  .|.|. ||..||||  ....|||...| . .    . ... |.. .| ...  .| . |.|| .||||.|||.....||....|.. .. .|.| ||
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSAGVGRSGVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLKA
||||||||.|... |...   .|  . |   |.|...|.|| ...||  |.||..|| |..
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 617-871 1.5e-77 255.8 In-house 5-261 (263) alignment 
Range on Protein: 617-871
Range on HMM: 5-261/263.0
YFQELYRKKPGMAMDDARKPENLPKNRYRDILPYDETRVKLFKG-----SDYINANFVNMEvpshGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIML
.|..| ....   ...|.|..|  ||||..|||||.||||| |      |||||||.....        .|||.||||..|. |||.|.||.......||
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga....nkkkkyIatQgPlpstvedFWrmvweekvkiivml

TTTMERGRVKCHQYWPEG-EDTWTFGNLEVVCNKIRDFSPSYVYREMYVTDTTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREGTSTPAVV
|  .|.|. ||..||||  ....|||...| . .    . ... |.. .| ...  .| . |.|| .||||.|||.....||....|.. .. .|.| ||
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSAGVGRSGVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLKA
||||||||.|... |...   .|  . |   |.|...|.|| ...||  |.||..|| |..
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
0045098 (Phosphotyrosine protein) phosphatases II 607-870 6.9e-77 253.8 In-house 2-270 (278) alignment 
Range on Protein: 607-870
Range on HMM: 2-270/278.0
ENLESGDLLVYFQELYRKKPGMAMDDARKPENLPKNRYRDILPYDETRVKlfkgsDYINANFVNMEvPshgivLRYIAAQGPLEKTCGDFWQMIWEQEST
|.| |.||| .|..|..  .   . .| ...||.||||.|||||| .|||     |||||.....  |      ..||.||||..|. |||.|.||. .|
ealasldlllefefllllgipseitpalylgnldknRykdilpydhsrVk.....dYINAsyidgy.p.....kkfIatqgPlpstvadfwrmlwelgit

LVIMLTTTMERGRVKCHQYWPEgEDTWTFGNLEVVCNKIRDFsPSYVYREMYVTDT----TTLRSRVIIQLQYLAWPDHDVPDDA--TDFLEFVHSVRHY
 ..|||. .|.||.||.||||| ....|.|...| . ..  . . |..| ..||..    ..| || . .|.|| ||||.||..   . |||..  .|..
vivmltelvelgrekcaqywpe.ggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirea

RE-------------GTSTPAVVHCSAGVGRSGVLMFIETAFGMIeGaEPVYPLELVRRMRDQRGS-LIQTPGQFLFVCEATLK
..             . ..| .|||||||||.|.|  . .   .. . . | .|| |. .| ||.   .|...|. |..|. |.
lkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell.e.ggvdlleavkelrsqRpglavqnleqyrflyeflle
0039614 (Phosphotyrosine protein) phosphatases II 609-870 1e-76 253.6 In-house 29-287 (297) alignment 
Range on Protein: 609-870
Range on HMM: 29-287/297.0
LESGDLLVYFQELYRKKPGmaMDDARKPENLPKNRYRDILPYDETRVKLF------KGSDYINANFVnmevPSHGI-VLRYIAAQGPLEKTCGDFWQMIW
.... ||  |.||.. ||   .  |..||| .||||.|||||| .||||        .||||||..|    . . .   ..||.||||..|..|||.|.|
nsktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyv....dgydlltrkfIatqgPlpetvedFwrmvw

EQESTLVIMLTTTMERGRvKCHQYWPEGEDtwTFGNLEVVCNKIRDfSPSYVYREMYVTDttTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYR
|| .| ..|||...|.|| ||.||||| ..  |.|.. | . |.    . |..|.. ||.  .  || . ..||. ||||.||......|||.. ||...
eqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkveh.ldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvreal

EG--TSTPAVVHCSAGVGRSGVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLK
.    ..| .|||||||||.|..  . ... ..|    | .|| |...| ||.  .|||.|. |...| |.
aelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydalle
Y_phosphatase Protein-tyrosine phosphatase 638-869 1.5e-74 245.7 Pfam-A 1-234 (235) alignment 
Range on Protein: 638-869
Range on HMM: 1-234/235.0
NLPKNRYRDILPYDETRVKL--FKG-SDYINANFVNMEVpShgiVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQYWP-EGEDTW
|. ||||.||||||.|||||   .| |||||||.|..   .     ..||.||||..|..|||.|.|........|||. .|.||.||.|||| | |.. 
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyk.e...kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

TFGNLEVVCN-KIRDFSPSYVYREMYVTDTTTL-RSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREGTSTPAVVHCSAGVGRSGVLMFIETAFGM
|.|...| .  |. . . .|. |.. ......  ..| . ||.| .||||.||......|.....|....| .|.| ||||||||||.|... ..... .
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

IEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATL
.|  | |  |..|...| || ...|.  |. |...| |
leaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 638-869 1.5e-74 245.7 In-house 1-234 (235) alignment 
Range on Protein: 638-869
Range on HMM: 1-234/235.0
NLPKNRYRDILPYDETRVKL--FKG-SDYINANFVNMEVpShgiVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQYWP-EGEDTW
|. ||||.||||||.|||||   .| |||||||.|..   .     ..||.||||..|..|||.|.|........|||. .|.||.||.|||| | |.. 
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyk.e...kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

TFGNLEVVCN-KIRDFSPSYVYREMYVTDTTTL-RSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREGTSTPAVVHCSAGVGRSGVLMFIETAFGM
|.|...| .  |. . . .|. |.. ......  ..| . ||.| .||||.||......|.....|....| .|.| ||||||||||.|... ..... .
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

IEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATL
.|  | |  |..|...| || ...|.  |. |...| |
leaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_PTPRB_pd Subfamily PTPRB 618-872 2.1e-74 245.2 In-house 31-285 (293) alignment 
Range on Protein: 618-872
Range on HMM: 31-285/293.0
FQELYRKKPGMAMDDARKPENLPKNRYRDILPYDETRVKL-----FKGSDYINANFVnmevPSHGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLT
..||   .  .|.. |....|  ||||..|||||..||||      .||||||||..    | .     .||.|||| .|  |||.|.||..|. ..|||
yeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyi....pgynsprefiatqGPlpetvddfWrmvwekkssiivmlt

TTMERGRVKCHQYWPEGEDTWTFGNLEVVCNKIRDFsPSYVYREMYVTDttTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYR--EGTSTPAVV
 ..|.|.|||..|||. |.. ..|...|  .. ..    .| ||. ..   . ..| . |.....||||.||.... .|.||. ||..   . ...| ||
qlvekgkvkCeeYWPadeepvlyGdikvtlvaeeel.edwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivv

HCSAGVGRSGVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLKAY
||||||||.|... ... .  ||  . |  . .| ..| .| .|.||  |..|. .. |.  
hCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll
0040439 (Phosphotyrosine protein) phosphatases II 633-870 7.5e-73 240.5 In-house 6-244 (249) alignment 
Range on Protein: 633-870
Range on HMM: 6-244/249.0
ARKPENLPKNRYRDILPYDETRVKLFK-----GSDYINANFVnmevPSHGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQYWP
|..|||..||||.|||||| .||||       .||||||...    .   |  |.||.||||..|..|||.|.||. .| ..|||...|.||.||.||||
allpenkdknrypdilpydhsrvklsilpglflsdyinAsyi....dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

EgEDTWTFGNLEVVCNKIRDfSPSYVYREMYVTDTTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREG--TSTPAVVHCSAGVGRSGVLMFI
. ......|.. | . ..   ...|. |....|.. .  || . ..||. ||||.||..  |.|.|.. ||...|   ...| .|||||||||.|..  .
l.ggsleygdftvtllsvev.kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

ETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLK
 ... ..|    | ..| |. .|.||.  .|.|.|. |..|| |.
ylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle
0042113 (Phosphotyrosine protein) phosphatases II 633-870 1.4e-72 239.3 In-house 4-241 (245) alignment 
Range on Protein: 633-870
Range on HMM: 4-241/245.0
ARKPENLPKNRYRDILPYDETRVKLFKG-----SDYINANFVnmevPSHGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQYWP
|..||| .||||.|||||| |||||        ||||||..|    . . |  ..||.||||..|..|||.|.||. .| ..|||...|.|||||.||||
allpenkdknrysdilpydhtrvklspdggdldsdyinasyv....dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywp

EgEDTWTFGNLEVVCNKIRDfSPSYVYREMYVTDTTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYRE-GTSTPAVVHCSAGVGRSGVLMFIE
. ....|.|.. | . ..    ..|. |.. ||.. .  || .|...|| ||||.|||.  ..|.|.. ||.... . ..| .|||||||||.|... . 
l.gesltygdftvtllseeh.lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaay

TAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLK
... ..|    | . | |...|.||.  .|||.|. |. || |.
lmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
0037934 (Phosphotyrosine protein) phosphatases II 632-869 1.3e-71 236.3 In-house 4-239 (243) alignment 
Range on Protein: 632-869
Range on HMM: 4-239/243.0
DARKPENLPKNRYRDILPYDETRVKLfKGSDYINANFVNMEvPshgivlRYIAAQGPLEKTCGD----FWQMIWEQESTLVIMLTTTMERGRVKCHQYWP
 |..||||.||||.|||||| .|||| .||||||||....  |      |.|| ||||..|. |    ||.|.||. .| ..|||...|.||.||.||||
iallpenlsknrysdilpydhsrvkl.egsdyinanliyvt.p......rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

egeDTWTFGNLEVVCNKIRDFSPsYVYREMYVTDTT-TLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHY--------REGTSTPAVVHCSAGVGR
   ...|.|...| . ... ..  |..|..... .  .  .| .|...||.||||.|||. .|.|.|.. || .         . .. | .|||||||||
...gevtygdftvtllseehldd.ytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR

SGVLMFIETAFGMIegaePVYPLELVRRMRDQRGS-LIQTPGQFLFVCEATL
.|.|  . .   ..     | ..| |...|.||.   .|||.|. |. || |
tGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeall
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 598-870 4.2e-71 234.6 In-house 7-278 (318) alignment 
Range on Protein: 598-870
Range on HMM: 7-278/318.0
LKVSIEQLREnleSGDLLV--YFQELYRKKPGMAMDDARKPENLPKNRYRDILPYDETRVKLF-----KGSDYINANFVNMEVPSHgivlRYIAAQGPLE
|.  ...|||   ||.||.   ...| |..  ..  .. .| |  |||| .||.||.|||||      .||||||||...    ..     |||||.|| 
leshvrrlre...sGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkk....ayiaaqaPlp

KTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQYWPEgEDTWTFGNLEVVCNKIRDFSpSYVYREMYVTDTTTLRSRVIIQLQYLAWPDHDVPDDATDF
.|. |||.|.|||.|....||| ..|||..|.|.|||. ... ..|.| |  ..  ..| .|| ||. || | .  ||.. | .| .|||..||......
etieDfWrmvWeqnsavivmltqeeergkakvhryWPs.kgsrsygklvvelkeevels.dyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgasl

LEFVHSVRHYR-EGTSTPAVVHCSAGVGRSGVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLK
|..| .|...  . . .| |||||||||| || . ...    |.  . |  .. |...|.||  ..||  |. |. .. |.
ldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvlle
subfamily_PTPN12_pd Subfamily PTPN12 619-871 1.1e-69 229.6 In-house 21-276 (290) alignment 
Range on Protein: 619-871
Range on HMM: 21-276/290.0
QELYRKKPGMAMDDARKPENLPKNRYRDILPYDETRVKLFK-----GSDYINANFVNMEVPShgivLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTT
.| |...  .  . ..|.||  ||||.||||||..||.| |     |||||||||..    .    |.|||||||| ||  |||.||||.. ..|.|.  
sekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegk....leyiaaqgPLpktlddfWrmiweknveivvmaCr

TMERGRVKCHQYWPEG-EDTWTFGNLEVVCNKIRDFSPSYVYREMYVTDTttLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREGTSTPAVVHC
 .| |. ||..||||  |.. .||..|| ... . ..  .. | . |.      ||.. |..| |||||.||  |.. ||....||...|  ..| ||||
evelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhC

SAGVGRSGVLMFIETAFGMIEGAEP---VYPLELVRRMRDQRGSLIQTPGQFLFVCEATLKA
|||||| |... |. .  ...       .   .||...| || .|.||  |. .| .| .. 
saGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavael
subfamily_PTPN6_pd Subfamily PTPN6 604-868 1.2e-69 229.6 In-house 18-293 (306) alignment 
Range on Protein: 604-868
Range on HMM: 18-293/306.0
QLRENLESGDLLVYFQELYRK--KPGMAMDDARKPENLPKNRYRDILPYDETRVKL----FKGSDYINANFVNMEVPSHGivLRYIAAQGPLEKTCGDFW
. .|.||  ..   |.|| ..  |  .  ....||||  ||||. |||.|.|||.|     .||||||||... ||...    .|||.|| ||.|  |||
keeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsd..ksyiatqgclettvsdFW

QMIWEQESTLVIMLTTTMERGRVKCHQYWPEGEDTWTFGNLEVVCNKIrDFSPSYVYREMYVT-DTTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHS
.|.|...|....|.|. .|||. || .|||. |.. ..|...| . .  .   .|..||. |.  ..  ..| ..|... .||||.|| |   .|.|.. 
rmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvse.ksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfled

VRHYREGTS----TPAVVHCSAGVGRSGVLMFIETAFGMIEGAEPVYPLE---LVRRMRDQRGSLIQTPGQFLFVCEAT
|.. .| ..     | |||||||.|| | .. |..   .||     ....   ||. .|.||  |.||  |. || .| 
vnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykai
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 601-874 7.6e-69 226.9 In-house 5-278 (281) alignment 
Range on Protein: 601-874
Range on HMM: 5-278/281.0
SIEQLRENLESGdLLVYFQELYRKKPGMAMDDARKPENLPKNRYRDILPYDETRVKL-----FKGSDYINANFVNmevpSHGIVLRYIAAQGPLEKTCGD
 ..||..| ..| .   ...|.    . .   ....||  ||||..|  || ||||.      | .||||||||.    .     .|||.|||. ... .
hlkqlsqndnaG.fieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvp....gykgekeyiatqgPvPaslva

FWQMIWEQESTLVIMLTTTMERGRVKCHQYWPEGEDTWTFGNLEVVCNKIRDfSPSYVYREMYVtDTTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVH
||||.|||. ....|.|  .| |..|||.|||... . ..|.. |  .. .. ...|. |.. . ....  .| . ||.|.||||| ||......||| .
fWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeee.katyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrk

SVRHYRE-GTSTPAVVHCSAGVGRSGVLMFIETAFGMI-EGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLKAYDD
 |....|  | .| |.||||||||.|. . .....  . . .|.. . ..|. .| .|  ..||  |. ||  | |.| | 
evlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 629-875 7.9e-69 226.9 In-house 38-282 (288) alignment 
Range on Protein: 629-875
Range on HMM: 38-282/288.0
AMDDARKPENLPKNRYRDILPYDETRVKLFK-----GSDYINANFVNMEVPSHgivlRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCH
. . .|...| .|||||.||||||.|||| |     |.|||||.... |  ..    .|||.|||| .| .|||....|.... ..|||  .|.|. ||.
svtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkk....kyiatqgPladtvndfWelvyenktstivmltelveggktkCe

QYWPEGEDTWTFGNLEVVCNKIRDFSpSYVYREMYVTdtTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREGTSTPAVVHCSAGVGRSGVLM
.|||....   .|...|.  . ..   ..| |.. .    .   . | |.||||||||.||......||... |    .  . | .|||||||||.|. .
eYWPdadkpknyGsvtvtlveskele.dfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFi

FIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLKAYDDE
 ....  ..|  . .  .. | ..| || .|.||  |. |. |. |.  ...
aldalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllslieed
subfamily_PTPN14_pd Subfamily PTPN14 603-869 1.3e-68 226.3 In-house 14-293 (300) alignment 
Range on Protein: 603-869
Range on HMM: 14-293/300.0
EQLRENLESGDLLVYFQELYRKKPGMAMDDARKPENLPKNRYRDILPYDETRVKLFKG----SDYINANFVNMEVPSHgiVLRYIAAQGPLEKTCGDFWQ
..| ..||.| . . .... .|.    .. |. ||| .|||..|.|||...||.|       ..||||  ... | ..   . ||.||||||.|. ||||
kilekkleegkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggk..ersyivaqgPleltvqdfWq

MIWEQESTLVIMLTTTMERGRVKCHQYWPEG---EDTWTFGNLEVVcNKIRDFSPSYVYREMYVTDTTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFV-
|.|||. .|..||| . | |. |...|.|.    ..| .||. .|. .| .. |.|.. . . .    . . | .. |||  ||||.||.| ..||... 
mvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvt.tkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLe

--HSVRHYREGTS------TPAVVHCSAGVGRSGVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATL
  .|||.  . ..       | .|||||||||.|||.  .     .|  | .   . ..|.| || .|.|| .|. || .. .
evqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvli
subfamily_PTPN1_pd Subfamily PTPN1 620-870 2.8e-65 214.9 In-house 14-269 (290) alignment 
Range on Protein: 620-870
Range on HMM: 14-269/290.0
ELYRKKPGMAMDDARKPENLPKNRYRDILPYDETRVKLFKG-SDYINANFVNMEVPSHgivlRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERG
.. ..   . . .|..||| ..|||||. ||| .|.|| ..  |||||..|..|   .    .|| .|||| .|.. ||||.|||.|  |.||   .|..
dirkeasdfptreaklpenrnlnryrdvspydhsrikleradndyinaslveleeakr....syiltqGPlpntvdhfWqmvWeqkskavvmlnkvveke

RVKCHQYWPEGED--TWTFGNLEVVCNKIR-DFSPSYVYREMYVTDTTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYR--EGTSTPAVVHCS
..||.||||.||.  . .. . ..  . |. . .  |. | . ... .| ..|.|..  |..|||  ||.  . ||.|.. ||.         |||.|||
qikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcs

AGVGRSGVLMFIETAFGMIEGAEPVYPLEL---VRRMRDQRGSLIQTPGQFLFVCEATLK
||.|||| .....| .  ||  . .  ...   .  .| .|  ||||. |. |   | |.
aGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 615-872 8.6e-64 210.6 In-house 26-283 (319) alignment 
Range on Protein: 615-872
Range on HMM: 26-283/319.0
LVYFQELYRKKPGmAMDDARKPENLPKNRYRDILPYDETRVKLF-----KGSDYINANFVNmevpSHGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVI
   |..|   ..   .| | |.|| .||||..||.|| |||.|      .|||||||.|..    ..    ..||.|.|||.|  |||.|.||.||  |.
ekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfid....gyqerekfiatqaPlentiedfWrmvWeeessivv

MLTTTMERGRVKCHQYWPEGEdTWTFGNLEVVCNKiRDFSPSYVYREMYVTD-TTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREG-TSTP
|||   |...||...|||| .  ...|.| |  .. ..    |. |.. .   .. . .| . . ||..|||||||..||  |.... .|. ||. .| |
mltklveklkvklkkywpeen.feeyGrlivtlee.eeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgP

AVVHCSAGVGRSGVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLKAY
 |||||||||| |  . .. ..  ..  . .   . |.|.| ||  ..|.| |. |. || |.| 
ivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleav
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 618-872 5.3e-62 204.7 In-house 33-290 (298) alignment 
Range on Protein: 618-872
Range on HMM: 33-290/298.0
FQELYRKKP---GMAMDDARKPENLPKNRYRDILPYDETRVKLFK-----GSDYINANFVNMEVPSHgivlRYIAAQGPLEKTCGDFWQMIWEQESTLVI
||.| . .       .. ||||||  |||| ||...| .|| | |      |||||| |..    ..     .||.|.||..|  |||.|..|.... ..
fqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn....afiatqaPltetvedFWrmvteedigtiV

MLTTTMERGRVKCHQYWPEgEDTWTFGNLEVVCNKIRDFSpSYVYREMYVTDTTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREGTS-TPA
|||.. | ...|.|.|||. | . |.|...|   .  .|.  .. |.. |..... ..| . ||..  |||..||  ||  |.... || ... .  .| 
mltnleeldktkyhkywPd.egketygeitvsllskeefa.dlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpv

VVHCSAGVGRSGVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLKAY
.|.|||||||||  . |.. .  ..  . |  .. |...| .|  ..||  |. |. ||.|.| 
ivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleal
subfamily_PTPRA_pd Subfamily PTPRA 602-872 6.3e-62 204.4 In-house 16-295 (330) alignment 
Range on Protein: 602-872
Range on HMM: 16-295/330.0
IEQLRENL--ESGDLLVYFQELYRKKPG----MAMDDARKPENLPKNRYRDILPYDETRVKLF-----KGSDYINANFVNMEVPSHgivlRYIAAQGPLE
.|.| |..   | |    |.| .   |      ... | | ||  |||. .||||| .|| |      . |||||| |..     .    ..||||||.|
vekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekd....kfiaaqGPke

KTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQYWPEgEDTWTFGNLEVVCNKIrDFSPSYVYREMYVT---DTT-TLRSRVIIQLQYLAWPDHDVPDD
.|  |||.|||||.|. ..|||   || . ||.||||. | ..|.||. |  ..    . .|  |.. |.   |.|   .||.. |. . .|||  || .
etvedfwrmiweqksativmltelkerkeekcaqywPd.eGlvtyGnirvevede.tvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfe

ATDFLEFVHSVRHYREGTSTPAVVHCSAGVGRSGVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLKAY
.   |.... |.. .. .. | ||||||||||.| .. ... . ...  . |   | |.|.| ||  ..||  |. |. .. |. |
piGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy
subfamily_PTPN9_pd Subfamily PTPN9 617-869 1.7e-60 199.6 In-house 21-287 (297) alignment 
Range on Protein: 617-869
Range on HMM: 21-287/297.0
YFQELYRKKPGMAMDDARKPENLPKNRYRDILPYDETRVKLFK-----GSDYINANFVNMEVPSHGivlrYIAAQGPLEKTCGDFWQMIWEQESTLVIML
 ..|. ....   .. .... || |||| |.| ||||||.| |      |||||||||.     ..    .||.||||.||. |||.|.||||   ..| 
eyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkka....fiatqGplkktvsdfWrmvWeqevlvivmt

TTTMERGRVKCHQYWP-EGEDTWTFGNLEVVCNKIRdFSPSYVYREMYVTDTTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREG-------
| ..||||.|| |||| | |..  ||.|.|   ...  .  |. | . .....| .|| ..  |.|.|||. ||..|...|.... ||...         
trvvergrlkcgqyWpleeessaefgdlsvsnveve.eeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgd

------TSTPAVVHCSAGVGRSGVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATL
      .  | |||||||.||.| .. .. .   .|  . |   | |...| ||   |||| |. |   | |
ewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavl
subfamily_Ptp69D_pd Subfamily Ptp69D 617-871 2.2e-60 199.4 In-house 27-285 (307) alignment 
Range on Protein: 617-871
Range on HMM: 27-285/307.0
YFQELYRKKPGMAMDDARKPENLPKNRYRDILPYDETRVKLFK-----GSDYINANFVNmevpSHGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIML
 ...| ...       . | ||. |||| || ..|.||||| |      ||||||.|..    ..    ..||||.|.| | ||||.||.|||.||..||
eyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfik....gykekkkfiaaqdPveatigDfWRmiaeqevtlivml

TTTMERGRVKCHQYWPEGeDTWTFGNLEVVCNKIRdFSPSYVYREMYVTDTT-----TLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREGTST
.   |  | ||..|||.  |.  .|.. | . . . . . |. ||..|. .         || ..| .|..|.|  ||. |.  |.... ||.  .   .
snlteknrkkcakYWpie.devqygdilvklvsee.khsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrs

PAVVHCSAGVGRSGVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLKA
| ||||||||||||... ..  .  ..  . |   | |. .| ||  |.|   |. |.  | |. 
PivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldy
subfamily_PTPRK_pd Subfamily PTPRK 627-871 4.7e-59 194.8 In-house 34-276 (314) alignment 
Range on Protein: 627-871
Range on HMM: 34-276/314.0
GmaMDDARKPENLPKNRYRDILPYDETRVKLFK-----GSDYINANFVnmevPSHGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVK
|   | |.| ||  |||. |||.|| .||.|        ||||||...     |.     .|..||||..|  |||......... ..|||  .| ||||
g..wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaali....dsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvk

CHQYWPEgeDTWTFGNLEVVCNKIrDFSPSYVYREMYVTD--TTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREGTSTPAVVHCSAGVGRS
| .||||  || ..|...| . .  .    .| | . |.    .    |.. |.|.|.|||||||  || .|..|. | . .| .  . ||||||| ||.
ClkyWPe..dtevygdikvelvet.ellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrt

GVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLKA
|. . |..   |||  . |   . |. .|...  ...|  |. |. .. | |
Gtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvilea
subfamily_PTPN23_pd Subfamily PTPN23 638-871 2.5e-58 192.2 In-house 43-279 (288) alignment 
Range on Protein: 638-871
Range on HMM: 43-279/288.0
NLPKNRYRDILPYDETRVKLFKGS-DYINANFVNMEVPShgiVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQYWPEGED-TWTF
.  |||.|||||||..|||| ..  ||||| ||.  .|       .||.|.||..| .|||.|..|| | ...||..  |.|. |...|||| .. | .|
yseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspg...cPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkf

GNLEVVCNKIRDFSpSYVYREMYVTDTTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRH----YREGTSTPAVVHCSAGVGRSGVLMFIETAFGM
|.|.| ... |. .  .| |.. ..   . . . .  ||. .||.. ||.   ..|.|.. |..     .. . || ||||||||||.||.  . .|   
gdlsvtlksvrete.thvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavre

IEGAEPVYP-LELVRRMRDQRGSLIQTPGQFLFVCEATLKA
.|  . .   ...|.|.| ||   .|.  |. |. || |.|
lekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 632-872 3.8e-57 188.3 In-house 32-277 (287) alignment 
Range on Protein: 632-872
Range on HMM: 32-277/287.0
DARKPENLPKNRYRDILPYDETRVKLF----KGSDYINANFVnmevPSHGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQYWP
 | .  .  |||| |.||.|.||| |     .||||||||.|    .|.    ..||||||.  | .|||....|..|. ||..|  .| .| ||..|||
aaeelaavkknryadvlPiddtrvllsaegelGsdyinanyv....asytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywP

EGEDTWTFGNLEVVCNKIRDFSPSYVYREMYVTDTTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSV----RHYREGT-STPAVVHCSAGVGRSGVL
| |     |   ||  .    .| |  | . . |  |  .||. ||..|.|||. ..  |  .. || .|       |...   | |||...|.||||.|
erevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGil

MFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLKAY
. . .   . |    | .   | |.| .| .|.|.. |. ...||    |
latlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyy
subfamily_PTPRG_pd Subfamily PTPRG 628-871 2.5e-55 182.8 In-house 37-286 (563) alignment 
Range on Protein: 628-871
Range on HMM: 37-286/563.0
MAMDDARKPENLPKNRYRDILPYDETRVKLF-----KGS-DYINANFVNMEVPSHgivlRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVK
. .. ..||||  |||| .|..||..||||      |.. ||||||...    |.     .||.||||..|. |||.|||||......|.|   |||| |
ldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqksk....afiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrk

CHQYWPEgEDTWTFGNLEVVCNKiRDFSPSYVYREMYVTDTTT------LRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREGTSTPAVVHCSAG
|..|||. ... |.|.|.|   . ..   .|  |.. . ..           ....| .|  ||||.||. ..  | ||.     .. .  | |||||||
cdvYWPk.desetygalqvtlie.eevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaG

VGRSGVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLKA
|||.|... ..|    |.  . |  .......| ||  |.||  |..|. .| |.|
vgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdallea
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 633-873 8.2e-55 180.7 In-house 4-243 (250) alignment 
Range on Protein: 633-873
Range on HMM: 4-243/250.0
ARKPENLPKNRYRDILPYDETRVKLFKGS-----DYINANFVNMEVPShgivLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVkCHQYWP
|.||.|. |||| ||...|..|| |.| .     ||||| |..    .      .||.||||..|  |||.|..|..|. ..|||.  | ... .|||||
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyder....kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP

EgEDTWTFGNLEVVCNKIRDFSpSYVYREMYVTDTTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREG-TSTPAVVHCSAGVGRSGVLMFIE
  | . ..|.. |   .   |.  |. |.. .. ..   .|.. ||....|||  ||. ||  ||... |.  ..   ..| .|.|||||||||  . |.
v.ekaekyGdvtvsllskeefa.dytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaid

TAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLKAYD
. .  ..  . |   ......| .|   ...  |. || |. ||| |
avlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 631-868 2e-54 179.6 In-house 21-264 (274) alignment 
Range on Protein: 631-868
Range on HMM: 21-264/274.0
DDARKPENLPKNRYRDILPYDETRVKLFK------GSDYINANFVNMEvpsHGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQ
.. . . .  ||||..||| ...|| | .       |.|||||..      ..    |.|.|||| .|  |||.||...|.....|||   |. . ||..
eeldvfgsqtknryktilPnensrvllesessededssyinanyikGy...deeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCav

YWPEGEDT---WTFGNLEVVCNKIRDfSPSYVYREMYVTDTTTlrSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREGTS---TPAVVHCSAGVGR
|.|. ||.    ..|..|.  .|| .    |  |....  ..   .| ..   | .||||..||||. .|..|. |.. || ..   .|.|||||||.||
yfPdaedyeiserygdveikvekive.rndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGr

SGVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEAT
 |. . |. |   ..  . |  |..|  .| .|| ..||  |. .. .| 
tGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihral
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 633-872 7.9e-54 177.8 In-house 46-284 (297) alignment 
Range on Protein: 633-872
Range on HMM: 46-284/297.0
ARKPENLPKNRYRDILPYDETRVKLFK-----GSDYINANFVNMEVPshgivlRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRvKCHQYWP
|.|  |..|.||..|||||  ||||        |||.|| ||.          |.|. | | . |  |||.|..... . ..||.   || . || .||.
aekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh......rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWs

EGeDTWTFGNLEVVCNKIRDFSpSYVYREMYVTDTTTLRSRVIIQLQYLAWPDHDVPD--DATDFLEFVHSVRHYREGTST-PAVVHCSAGVGRSGVLMF
.   . |||.. || . . . .  .. ||. ||   .   ||. | |.. |||..|.   .|. .|.... ||.  ....  | .|||.||||| |||. 
dk.gvttfGdvsvvllsvsere.GfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvllt

IETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLKAY
|.     ..  . |  ..||...|..|  |.||  |. || .| |.| 
idsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleal
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 616-867 1e-53 177.5 In-house 26-278 (305) alignment 
Range on Protein: 616-867
Range on HMM: 26-278/305.0
VYFQELYRKkpGMAMDDARKPENLPKNRYRDILPYDETRVKLFK----G-SDYINANFVNMEVPSHgivlRYIAAQGPLEKTCGDFWQMIWEQESTLVIM
. ...||..  . ..|  .| .|  |||...| ..|. |..| .    . ||||||..|.    ..    .||.|||||..|  |||..|.|   . ..|
aqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkk....kyivaqgPlkntvadfWrliveekvstivm

LTTTMERGRVKCHQYWPEGEDT-WTFGNLEVVCNKIRDFsPSYVYREMYVTD-TTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYRE-GTSTP
|| ..| |. ||.||||| .     ||...|  .  . . . |. |.. ..   .   ||...|.|   |||| ||. || .|.... |.. .. .  .|
ltklveggkdkCrqYWpesktekkefgefsvelksekta.sdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvp

AVVHCSAGVGRSGVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEA
 .|||||||||.|| . .. |.  ..  | |   |.....| .|  ..||  |. |. .|
llVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhda
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 614-870 2.1e-53 176.7 In-house 36-289 (319) alignment 
Range on Protein: 614-870
Range on HMM: 36-289/319.0
LLVYFQELYRK-KPGMAMDDARKPENLPKNRYRDILPYDETRVKLF-----KGSDYINANFVNMEVPSHgivlRYIAAQGPLEKTCGDFWQMIWEQESTL
| | |. . ..  ..  .. |  ..|  |||. .||..|...|||       .|||||| ||.          .||||||||. |  |||.||||.... 
levefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkd....kyiaaqGPldntladfWrmiweyncst

VIMLTttmergRVKCHQYWPEGEDtWTFGNLEVVCNKIRDFSPsYVYREMYVTD-TTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYRE--GT
...||      . || ||||   .  . .. .|  . . . .  || |.. ... .     | | |  .| |||. ||| ..|.. .|. ||| ..    
ivllt......kdkcsqywplkiv.ikeerfkvkvdsveetae.yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenh

STPAVVHCSAGVGRSGVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLK
 .. ||||||||||.|| . ... . ...  . |   ..|| .|.||  |.|   |. |.  | |.
ranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_PTPRN_pd Subfamily PTPRN 628-868 5.3e-53 174.7 In-house 46-288 (297) alignment 
Range on Protein: 628-868
Range on HMM: 46-288/297.0
MAMDDARKPENLPKNRYRDILPYDETRVKLF-----KGSDYINANFVNMEVPSHGIvlrYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKC
 . . |....|. |||....||||..||||      . |||||| ..  . | . .   |||.|||| .|  |||||.||| ......||.  | |  .|
stkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapa...yiatqgplastvadfwqmvweqGvvvivnltrleeegvkqc

HQYWPE-GEDTWTFGNLEVVCNKIrdFSPSYVYREMYVTDTTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREGTSTPAVVHCSAGVGRSGV
..|||. |.... . ....| ..|  ..  |. | .|. .  | ..| . |. .|.||...||  |  .|||   |     | |.| |||||.|.||.||
krywpdeGsevyhiyevhlvsehi..wcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGv

LMFIETAF-GMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEAT
 . |.     .. |.  .     .  .||||  |..|  || |.  | 
yilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltav
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 641-869 9.4e-53 173.9 In-house 23-261 (270) alignment 
Range on Protein: 641-869
Range on HMM: 23-261/270.0
KNRYRDILPYDETRVKLFK-----GSDYINANFVNmevPSHGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQYWPEGEDT---
 |||.||||  .|||.| .      . |||||.|.     .|   .||||.|||. |  .||.||||...| ..|.|  .|.|| || .|||.  ..   
lnRyadiLPsPatRvrleeleedsataYinAnyvr...GfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvk

WTFGNLEVvCNKIRDFSPSYVYREMYVTDTTTlRSRVIiQLQYLAWPDHDVPDDAT------DFLEFVHSVRHYREGT--STPAVVHCSAGVGRSGVLMF
 ..|...| ..     .  |. ... .... . . |..   .| .|||| || ..       . |. .. ||.... .  ..| .|||||||||.|.|. 
ledgkikv.lalseekeegyiltrlrleekge.errlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlia

IETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATL
...|. ..|  . | .|......| .|  |.|.| |. |. .| .
lDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavv
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 625-870 1.8e-52 173.6 In-house 12-253 (284) alignment 
Range on Protein: 625-870
Range on HMM: 12-253/284.0
KPGMAMDDARKPENLPKNRYRDILPYDETRVKLF-----KGSDYINANFVNMEVPSHgivlRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTttmergR
 .|  .  |  ..|  |||. .||..|...|||       .|||||| |..     .    .|||.||||. |  |||.||||.... ...||      .
vngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkd....kyiatqGPldntladfWrmiweyncstivllt......k

VKCHQYWPEGEDtWTFGNLEVVCNKIRDFSPsYVYREMYVTD-TTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYRE--GTSTPAVVHCSAGV
 || ||||   .  . .. .|  . . . .  || |.. ... .     | | |  .| |||. ||| ..|.. .|. ||| ..     .. ||||||||
dkcsqywplkiv.ikeerfkvkvdsveesee.yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagv

GRSGVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLK
||.|| . ... . ...  . |   ..|| .|.|| .|.|   |. |.  | |.
grtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 629-872 4.1e-52 172.1 In-house 40-279 (315) alignment 
Range on Protein: 629-872
Range on HMM: 40-279/315.0
AMDDARKPENLPKNRYRDILPYDETRVKL-----FKGSDYINANFVnmevPSHGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCH
 .| |.| ||  |||| .|..||..||.|      ..|||.||||.    . .    ||||||||.  . .|||....|.. . ..||| ..|. . |. 
pldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfi....dGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkae

QYWPEGedTWTFGNLEVvCNKIRDFSPSYVYREMYVTDTTTLrsRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREGTSTPAVVHCSAGVGRSGVLM
.|||.     ..|.. |   |  .    |  | . |.    .  | ..||.| .||| .||  .. .....  |. ... . .. ||||||||||.| ..
kywpdk..kviyGkitv.trkseevnteytvrtlsvvfgdni..revvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfi

FIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLKAY
 ... .  .|  . .   ......|..|  ..|.  |. |. .| |...
tldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletf
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 630-869 2.2e-51 169.6 In-house 36-274 (315) alignment 
Range on Protein: 630-869
Range on HMM: 36-274/315.0
MDDARKPENLPKNRYRDILPYDETRVKL-----FKGSDYINANFVnmevPSHGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQ
   ||...| .||||..|||.|..||||        |||||| ..    .|      |||.||||. .  |||.|..... | ..|.|   |  ..|| |
qrvaretinfkknryknilPldsarvkleviddsPdsdyinasyi....ksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrq

YWPE-GEDTWTFGNLEVVCNKIRDfSPSYVYREMyVTDTTTlRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREGTSTPAVVHCSAGVGRSGVLM
|||.   |.  ||...|   ..       | |.. ||  .   || . | |.  |||. |. ... .|.... |.  ..    . .|||||||||.||..
ywPdrkadsvefGsikvellslea.dtdgvarkl.vtrkse.esrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvi

FIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATL
 |.     |. .. |  ...|. .|..|  |.||  .. |. .| |
sidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavl
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 637-868 2.9e-51 169.0 In-house 2-235 (237) alignment 
Range on Protein: 637-868
Range on HMM: 2-235/237.0
ENLPKNRYRDILPYDETRVKLF---KGSDYINANFVNMevpSHGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQYWPEGEDTW
||  |||| .|  || .|| |     |||||||....      |   .||||||||| .| |||||.|..  ....|||  .|. ..|||.|||. ..  
enkiknrygnivaydhsrvvlkgagsgsdyinatylkg...fdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpa

TFGNLEVVCNKIRDFSpSYVYREMYVTDTTTLRS-RVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYRE--GTSTPAVVHCSAGVGRSGVLMFIETAFG
..| | |   |  .||  |  | . ..  .||.  |.| | |. .|||. ||. .. .| | . . .  .    |.| ..||||||||.|... |.. . 
aygvltvslkkkeefs.dytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlr

MIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEAT
  .  . |   . |  . ..|  .|||  |..|. .. 
qakekkvvdiynyvysieedrpyiiqtkdqyvfihqti
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 633-873 5.6e-51 168.1 In-house 41-284 (290) alignment 
Range on Protein: 633-873
Range on HMM: 41-284/290.0
ARKPENLPKNRYRDILPYDETRVKLF--KGS-----DYINANFVNMEVPSHgivlRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQY
.  ..| ..||...|..||. |. |    |      .|||| ...    ..    .|||.|||...|  |||..||....| ..|||. .| |.|||.||
gltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekk....qyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqY

WPEGeDTWTFGNLEVVCNKIRDFSpSYVYREMYVTDTTT-LRSRVIIQLQYLAWPDHD-VPDDATDFLEFVHSVRHYREGTSTPAVVHCSAGVGRSGVLM
||.  || ..|. ..  .. . .. .|. |.. |.....  ... ..|.|  .|.... |.. .|  | . . ..  |  . |. |||||..||||.|..
Wpds.dtkaygefsikllneetln.eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfc

FIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLKAYD
 ..|.    .    .  .......| |.  ..||  |. ....  |.. |
aaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 636-871 8e-50 164.4 In-house 45-277 (287) alignment 
Range on Protein: 636-871
Range on HMM: 45-277/287.0
PENLPKNRYRDILPYDETRVKLFK-GSDYINANFVNmevpSHGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQYWPEGEDtWT
..| .|||...||..|. || | .   ||||| |..    ..    ..|.|..|. .|  .||..|.... | ..||.  .|  . .|.|||||..   .
sqnkdknRltqilvpdnyrvllkgehpdyinavfid....gykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.vv

FGNLEVVCNKIRdFSPSYVYREMYVTDTT-TLRSRVIIQLQYLAWPDHD-VPDDATDFLEFVHSVRHYREGTSTPAVVHCSAGVGRSGVLMFIETAFGMI
.|. ..   .    . .|. |.. |. .. .   . . | |. .|...  |.. .| .| . . ..  |  . |. |||||..||||.... ..|.    
lGeyniellnee.vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkc

EGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLKA
.    .  .......| |.   .||  |. |.... |. 
kteGviDvfqvlksqriqkpgsvqtveqykfindivley
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 633-869 2.4e-49 162.8 In-house 38-273 (515) alignment 
Range on Protein: 633-869
Range on HMM: 38-273/515.0
ARKPENLPKNRYRDILPYDETRVKL-----FKGSDYINANFvnmeVPSHGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQYWP
|..  | .||||..||||| .||||        |||.|| .    .||      |||.|||.. .  |||....... | ..|.|   |  ..|| .|||
aqeeinfkknryknilPydsvrvklevindnPhsdyfnasy....ipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWP

E-GEDTWTFGNLEVVCNKIRDfSPSYVYREMYVTDTTTlrSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREGTSTPAVVHCSAGVGRSGVLMFIE
.   |.  ||...|    .       . |.. |.      || . | ..  |||. || ... .| ... |.  ..  . | ..|||||||| ||.. |.
dkpgdsvkfGsikvelvslea.ctggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisid

TAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATL
     .. .. |  ...|. .|..|  |.||  |. |. .| |
svvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavl
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 621-872 1.3e-48 160.8 In-house 31-288 (325) alignment 
Range on Protein: 621-872
Range on HMM: 31-288/325.0
LYRKKPGMAMDDARKPENLPKNRYRDILPYDETRVKLF-----KGSDYINANFVNMEVPSHgivlRYIAAQGPLEKTCGDFWQMI--WEqesTLVIMLTT
|   . |.|.  | ||||  |||.......|..|| |        ||||||.... ..  .     ..||| || .| .|.|...  |.   . |.... 
llpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkd....vflaaqaPltatindlWrlvldWr...csvvvvln

TMERGRVKCHQYWPEG-EDTWTFGNLEVVCNKIRDFsPSYVYREMYVTDTTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREG------TST
 .. |  .| .|||.   .. ||| |||    | ..   ||.| . | ..    .| . |.|. .|.|  |.   . .. ... | .  |       .||
eldlgkdrcavywpkemgksktfGglevklrtieei.sdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkast

PAVVHCSAGVGRSGVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLKAY
| .|||||||||.||.. . .|   .     |  .. |...| .| |...|  |. .. ||  .||
pilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay
0041856 (Phosphotyrosine protein) phosphatases II 638-869 6.7e-46 151.5 In-house 1-168 (182) alignment 
Range on Protein: 638-869
Range on HMM: 1-168/182.0
NLPKNRYRDILPYDETRvklfkGSDYINANFVNMEVPSHGivlrYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTttmergrvkCHQYWPEGEdtwtfgn
||.||||.|||||| .|     ..||||||.. .  |.      .||.|||| .|. ||..|..|.  |....||         ...|||| .       
nldknrysdilpydhsr.....dldyInanlylgslpatr....fiatqgpllstvadflrmlkelgittivnlt.........eelywpell.......

levvcnkirdfspsyvyremyvtdtttlrSRVIIQLQYLAWPDHDVPDdATDFLEFVHSVRHyregTSTPAVVHCSAGVGRSGVLMFIEtafG---Mieg
                              | .||..|| ||||.|||   ..|.|.. |..     . | .|||||||||.|.|  .        .   
.............................erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaay...lmkkl...

aePVYPLELVRRMRDQRGSLIQTPGQFLFVCEATL
   | . | |. .| .|   ..|| |. |.  | |
..gvsleeavklvrsrRpgmvitpnqyfflqlall
0036282 (Phosphotyrosine protein) phosphatases II 660-866 8e-44 144.7 In-house 1-164 (174) alignment 
Range on Protein: 660-866
Range on HMM: 1-164/174.0
GSDYINANFVNMEVPSHgivlRYIAAQGPLEktcgdFWQMIWEQESTLVIMLTTTMERGRVKCHQYWPEgedtwtfgnlevvcnkirdfspsyvyremyv
|||||||..... . .     |.|| ||||.     ||.|..|. .| |.||.. .|.|..||..||||                               
gsdyinaspldlsyitp....rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................

tdTTTLRSRVIIQLQYLAWPDHDVPDDATdFLEFVHSVRHYREG-TSTPAVVHCSAGVGRSGVLMFIETAFGMIEgAEPVYPLELVRRMRDQRGSLIQTP
  . .  .| .||..|| |||| |||... .||||  |.....   . | .|||||||||.|.|. .     ...   .|  |.|||..| ||.  .|||
..lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtp

GQFLFVCE
.|. |. .
sQyrflyy
0051429 (Phosphotyrosine protein) phosphatases II 660-872 9.7e-44 145.4 In-house 3-225 (272) alignment 
Range on Protein: 660-872
Range on HMM: 3-225/272.0
GSDYINANFVNMEvPSHGIVLRYIAAQGPLEKTCGDFWQMiWEQESTLVIMLTTTMERGRVKCHQYWP-----------EGEDTWTFGNLeVVCNKIRDF
 |.||||..|..   .. .  |.....|||. |. |||.. .|.  . ...|....||||.||..|||           ... | ..|.| .|..    .
lsgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygal.rvtllseel

SPSYVYREMYVTDT-TTLRSRVIIQLQYLAWPDHDVPDDAtdFLEFVHSVRHyregtSTPAVVHCSAGVGRSGVLMFIETAFGMIEGAEPVY--------
 . |..||...| . ..  .| . .|.|..|||| ||..|  .||... ...     . | .||||||..|.|..  .      ..    |         
lldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly

PLELVRRMRDQRGSLIQTPGQFLFVCEATLKAY
..| |...|.||   .||..|.||..|| |...
leeaveelraqrpgavqteeqylflyeallell
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 638-870 2.6e-43 142.7 In-house 56-281 (290) alignment 
Range on Protein: 638-870
Range on HMM: 56-281/290.0
NLPKNRYRDILPYDETRVKLFKGS--DYINANFVNmevpshGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQYWPEGE-DTWT
.. ||||.|.   | ||| |  |   ||. ||.|.      |.   .| .||.|..|  |.|.|. ... . ..||   .| |. ||.||.|| | .. |
efkknrykdvvcndktrvilkdGydGdyvhanyvk......GlkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevlt

FGNLEVVCNKIRDFSPSYVYREMYVTDTTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHyregTSTPAVVHCSAGVGRSGVLMFIETAFGMIEG
||.. |.| .  |     . . . | |  . .. ..  |.  .|||. |.  .  .|  ....|.    .| | |||||||.||.| .. ||..  ..  
fGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrk....asGpvvvhcsaGiGrtGtfvaievglqilld

AEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLK
   . .|.||| .|. | . .|   |.| . |. |.
Gkeldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 628-870 4.3e-43 142.2 In-house 23-264 (283) alignment 
Range on Protein: 628-870
Range on HMM: 23-264/283.0
MAMDDARKPENLPKNRYRDILPYDETRVKLFK-GSDYINANFVNMEVpSHGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQYW
.  | |   || .|||...|.|.|  ||.|     ||||| |. ..  |.    .||.||.||..|  |||.|..... | ..|||  .|  |.|| |||
ldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsk.sykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyW

PEgEDTWTFGNLEVVCNKIRdFSPSYVYREMYVTDTTTLRSRVII-QLQYLAWPDHDVPDDATDFLEFVHSVRHYREGTSTPAVVHCSAGVGRSGVLMFI
|. . .  .|.. |  .|    | |.. .|. .   .. .| ...   |.  | . .       .. |   .   .|   .| |||||.|.||..|.. .
Pk.rGsedyGeftvtlrket.tsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaa

ETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLK
 ..   .     |   . |. || ||  ..|| .|. .| |. |.
sasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 633-871 2.6e-42 139.6 In-house 2-239 (239) alignment 
Range on Protein: 633-871
Range on HMM: 2-239/239.0
ARKPENLPKNRYRDILPYDETRVKLFKG-----SDYINANFVNMevpSHGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQYWP
|.|  |  |||| .|. || .|| | |      ||||||...       |    |||.|| .| ..||||.|.|..   ...|||  .|  . |||||||
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrd...ydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp

EgeDTWTFGNLEVVCNKIRDFSpSYVYREMYVTDTTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREGTSTPAVVHCSAGVGRSGVLMFIET
.   |  . || |   |   |.  |. | . ...      | . | ..  |||. ||. ||  | . . . .     . | |.||||||||.| .. |..
d..stskycnlrvtlrktevfa.dyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvida

AFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLKA
 .   .  . |  .. |. .|..|  ..||  |..|.  | |.|
mlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavlea
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 633-869 4.2e-42 138.9 In-house 3-238 (239) alignment 
Range on Protein: 633-869
Range on HMM: 3-238/239.0
ARKPENLPKNRYRDILPYDETRVKLFKG-----SDYINANFVNMevpSHGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQYWP
|.|  |  |||| .|. || .|| | |      ||||||...       |    |||.|| .| ..||||.|.|..   ...|||  .|  . |||||||
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrd...ydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp

EgeDTWTFGNLEVVCNKIRDFSpSYVYREMYVTDTTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREGTSTPAVVHCSAGVGRSGVLMFIET
.   |  . || |   |   |.  |. | . ...      | . | ..  |||. ||. ||  | . . . .     . | |.||||||||.| .. |..
d..stskycnlrvtlrktevfa.dyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvida

AFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATL
 .   .  . |  .. |. .|..|  ..||  |..|.  | |
mlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 638-870 1.9e-41 137.0 In-house 48-277 (439) alignment 
Range on Protein: 638-870
Range on HMM: 48-277/439.0
NLPKNRYRDILPYDETRVKL-----FKGSDYINANFVNMEVPSHgivLrYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRvkchqYWPEGEDT
. .||||.|. ..| ||| |        | |||||...     .   | |||.||| ..|. |||....|. .. ..|||  .|  .     |||  ...
dqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddk...l.yiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaev

wTFGNLEVVCNKIRDFsPSYVYREMYVTD--TTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREG-TSTPAVVHCSAGVGRSGVLMFIETAF
  .|.. | ...  .. | || | . | .   || . | ..|..|.||||..|| .|.  |.|....    .     | ||||||||||.| .. .. |.
.cygdiavrvdrniel.pnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdial

GMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLK
  .   . |    .|. .|.||  ..|.  |..|. .| |.
eqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 620-794 1.1e-40 134.4 In-house 15-190 (297) alignment 
Range on Protein: 620-794
Range on HMM: 15-190/297.0
ELYRKKPGMAMDDARKPENLPKNRYRDILPYDETRVKLFK---GSDYINANFVNMevPSHGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTME
 |.... | ..  |...  | |||||||| .|.||||| .   ..|||||..| .  |     |.|| |||||..|  |||....||.   ..|..   |
llldeargesfssakrnsslrknryrdilatddtrvkllrviterdyinadyvvf..pdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqe

RGRVKCHQYWPEGEDTwTFGNLEVVCNKIRDFSPSyvYREMYVTDTTTL---RSRVIIQLQYLAWPDHDVPDDATDFLEFV
 || ||  |||. ..       .|| . . ..|    .  ...|. . .   .|||.   |.|.|||| || |  |   | 
dGrdkcapywpsvvqe.rlkagdvvveflsstsde..fdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfq
0046846 (Phosphotyrosine protein) phosphatases II 659-869 8.8e-40 131.6 In-house 10-170 (176) alignment 
Range on Protein: 659-869
Range on HMM: 10-170/176.0
KGSDYINANFVNMEvpshgivlRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQYWPEGEDTWTfgnlevvcnkirdfspsyvyremy
 ..||||||.. .         |.|| ||||..|. ||..|..|.  |.|..||. .| ||.||..|||| |.                           
ldldyinanlilgs........rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi........................

vtdtttlrsrviiQLQYLAWPDHDVPDDaTDFLEFVHSVRHYREGTsTPAVVHCSAGVGRSGVLMFIEtafgMIEGAEPVYPLELVRRMRDQRG-SLIQT
             | ..| ||||.|||. ...||..  .| ...    | .||||||.||.|.|  .     ..|    . ..| ....|.||    .||
.............qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqt

PGQFLFVCEATL
|.|  |. |. |
peQyrflyefel
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 614-869 1.4e-39 130.9 In-house 18-274 (307) alignment 
Range on Protein: 614-869
Range on HMM: 18-274/307.0
LLVYFQELYRKKPGMAMDDARKpENLPKNRYRDILPYDETRVKL-FK--GSDYINANFVNMEVPSHgivlRYIAAQGPLEKTCGDFWQMIWEQESTLVIM
|   |..| .|.|     .| .  |  ||||.|.   | .|. . |.   |||| ||.. . .  .    ..|.||||||.|  .|| |. ...   |||
lvdefrvlakktpegvtveafs.antdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpk....kficaqgplentqysfwamaiqekvesvim

LTTTMERGRVKCHQYWPEGE-DTWTFGNLE----VVCNKIRDFSPSYVYREMYVTD-TTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRhyreGT
|  ..| ...||.||||  | .. .||.      |    .. ..|   . ..   .   . .|| | .||.  |||. ||.     ......||    . 
lckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavr....yd

STPAVVHCSAGVGRSGVLMFIETAF-GMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATL
  | |||||||||||| .. |      ||.| .     .||. .|.||   |||  |.|..    |
tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvll
subfamily_CG7180_pd Subfamily CG7180 633-870 5.1e-39 128.7 In-house 37-288 (296) alignment 
Range on Protein: 633-870
Range on HMM: 37-288/296.0
ARKPENLPKNRYRDILPYDETRVKLF--KG---SDYINANFVNmevpSHGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRvKCHQYWP
. . ||. |||. ...||| .|| |   .|   |||||| .|.    |.     ||  ..| ..| ..||......|.  |..|| |..  . ....|||
glrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvd....sflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywp

EGEdTWTFGNLEVVCNKIRDFSpSYVYREMYVTDT----------TTLRSRVIIQLQYLAWPD-HDVPDDATDFLEFVHSVRHYREGT-----STPAVVH
.      .|...|   . . ..   . |.. .| .           .   |.. ..|.  |.  . ||  .. ..|... || .|| .       | ||.
nks.keqygeifveiveekqya.nlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvv

CSAGVGRSGVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLK
.| |..|||| . |. .  ..|  | |   | |...| .|  |...  .. .. .  |.
ssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlle
0043147 (Phosphotyrosine protein) phosphatases II 660-865 1.5e-38 127.6 In-house 4-154 (172) alignment 
Range on Protein: 660-865
Range on HMM: 4-154/172.0
GSDYINANFVNMEVpshgIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTmergrvkchqywpegedtwtfgnlevvcnkirdfspsyvyremyv
|||||||..... .    |  |.|| ||||  |. |||.|..|.  |....||.                                              
gsdyinasyldlyy....ipdrfiatqgplrntladfwrmlkelgithivnltel.............................................

TDTTTLRSRVIIQLQYLAWPDHDVPdDATDFLEFVHSVRH-YREGTSTPAVVHCSAGVGRSGVLMFIETAFgmiegaEPVYPLELVRRMRDQRGSLIQTP
. ...| .| .||..|| ||||.|| ..  .|||.. ... . .  . | .|||||||||.|.|  .          . . ..| |. .|..|.  .|.|
lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnp

GQFLFVC
.|  |..
sqyrfly
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 638-870 6.6e-38 125.1 In-house 55-287 (305) alignment 
Range on Protein: 638-870
Range on HMM: 55-287/305.0
NLPKNRYRDILPYDETRVKLFKG--SDYINANFVNMEV-PSHgivlRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQYWPEGEDTWT
.  ||||.|.   |.. ||| |   |||| ||.|   . | .    |.|.|||||..|  .|| |. ..    ..||  |.| |..|| ||||       
aitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipek....rficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekl

FGNLEVVCNKIRDFSPSYVYREMYVTDTT-TL---RSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRhyreGTSTPAVVHCSAGVGRSGVLMFIETAFG
  .  .| ...    |     |. .|    |    ..  . .||.  |||  ||      ||.. ..|    |.  | |||||||.||.| .. ||  . 
elksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsair....gskvpivvhcsagigrtgtivaieyile

MIEGAEPVYPL-ELVRRMRDQRGSLIQTPGQFLFVCEATLK
 |    |. |. |||. .||||   ||.  |.||.    |.
kiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln
0049772 (Phosphotyrosine protein) phosphatases II 632-868 9.2e-38 126.1 In-house 40-276 (314) alignment 
Range on Protein: 632-868
Range on HMM: 40-276/314.0
DARKPENLPKNRYRDILPYDeTRVKL----FKGSDYINANFVNMEvpshgivLRYIAAQGPLEKTCGDF----------WQMI--WEQESTLVIM-----
 |....|  |||| ||||.| .||.|    ..|||||||..|.         |..||.||||| |. ||          |.|.  ... .  . |     
vadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf.......lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdev

----------------LTTTMERGrvkchqywpegeDTWTFGNLEVVCnkirdfspsyvyremY-------VtdtttlrSRVIIQLQYLAWPDHDVPdDA
                |.. ...|            . .|. .||  .                       .       .| .|.. .. .||...| . 
ladelsrLdaAlgKtpllildgng............neptaadlellk...............eelydpelf.......erlgikylripvpDgsap.ll

TDFLEFVHSVRHYreGTSTPAVVHCSAGVGRSGVLMFieTAFGMIEGaePVYPLELVRRMRDQRG-----SLIQTPGQFLFVCEAT
 ||.||.. .. .   . .| .|||.||.||.|....  .|. |.     | . | ....| .|      ..|... |..|. || 
edfdeflefieea..dkggpvlvHCkaGkgRtgtfvv..aaylmkll..gvsleealedvrlkRpinpnpgfieqleqyefileal
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 630-870 4.1e-37 122.5 In-house 37-234 (392) alignment 
Range on Protein: 630-870
Range on HMM: 37-234/392.0
MDDARKPENLPKNRYRDILPYDETRVKL-----FKGSDYINANFVnmevPSHGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGrvkchq
   |.|. ||.||||..|||||..||||        |||.|| ..    ||      |||.|||   .  |||.|..... | ..|.|   |        
qtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyi....psfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd......

ywpegedtwtfgnlevvcnkirdfspsyvyremyvtdtTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREGTSTPAVVHCSAGVGRSGVLMF
                                           | . | ..  |||.|||  .. .|.|.. |.      . | ..||||||||.||.. 
......................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvis

IETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLK
|..     . .  |  ...|  .| .|  ..||  |. |.  | |.
idsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle
0049260 (Phosphotyrosine protein) phosphatases II 677-865 1.5e-36 120.7 In-house 6-143 (152) alignment 
Range on Protein: 677-865
Range on HMM: 6-143/152.0
GIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQYWpegedtwtfgnlevvcnkirdfspsyvyremyvtdtttlrsrviiQLQYL
.   ..||.|||.. |. |||.|..|.  | ..|||. .|.|..||.||.                                             | ..|
ampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................qylhl

AWPDHDVPDDATDFLEFVHSVRHYREGTSTPAVVHCSAGVGRSGVLMFIETAFgmiegaEPVYPLELVRRMRDQRGSLIQTPGQFLFVC
 |||| |||..  .|.... ......  . | .|||||||||.|.|. .            | ..| |...| .|   ...|||  |. 
pwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_ptpA1_pd Subfamily ptpA1 631-822 8e-36 118.7 In-house 40-246 (418) alignment 
Range on Protein: 631-822
Range on HMM: 40-246/418.0
DDARKPENLPKNRYRDILPYDETRVKLFK-----GSDYINANFVNMEVPShgivlRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQY
 .  |  |  |||| .||| . |||.| |     ||||||||...   |      ..|..|||| .|  |||.|.||.   ...||.   |  |.|| .|
segdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk.....qfictqgplpntiadfwrmvwenrcriivmlsresencrikcdry

WPE---GEDTWTFGNLEVV--------CNKIRDFSPSYVYREMYVTDTTtlRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYRE------GTSTPA
|||   ||.   .|| . |         . |.|     . |.. .|      .| | | ||  ||||..|| .  | ...||.   ..          | 
wpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfeg..etrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpi

VVHCSAGVGRSGVL
.|||||||||.| .
ivhcsagvgrtgtf
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 629-870 4.3e-35 115.9 In-house 39-285 (305) alignment 
Range on Protein: 629-870
Range on HMM: 39-285/305.0
AMDDARKPENLPKNRYRDILPYDETRVKLFK--GSDYINANFVNMevPSHgiVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQYW
 |   .. ..  ||||.|.   |. ||||      .|| ||.|    |.     |.| .| |||||| ||| | ...    ..||   .|.|  ||..|.
kmkafkeaqeagknrykdvgcldnnrvklegpwpheyihanyvst..ptn..pkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyf

PEG-EDTWTFGNL----EVVC-----NKIRDFSPSYVYREMYVTDTTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYRegtsTPAVVHCSAGV
.   .|. .| .      | .      |.|. . . | . . | . .  ..| . .  .  |||  ||   .  ||...  |  .     | |||||||.
askdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpsk....gpivvhcsagi

GRSGVLMFIETAFGMIEGAEPVY-PLELVRRMRDQRGSLIQTPGQFLFVCEATLK
||.| ....|  .  . . . .     .....|.||   |||  |.||| .  |.
grtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 634-866 2.3e-33 110.2 In-house 36-287 (301) alignment 
Range on Protein: 634-866
Range on HMM: 36-287/301.0
RKPENLPKNRYRDILPYDETRVKLFKG-------SDYINANFVNMEVPSHgivlRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQYW
 . || . ||...| .||. |. | .         .||||....    ..    ..||||||..||  |||..||..  . ..|.| . |. . ||.|||
lseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekk....kfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqyw

PEGE-DTWTFGNLEVVCNKIRdFSPSYVYREMYVT--DT-------------TTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREG-TSTPAV
|..| .. .||...|  ..     |..| |.. |.  |.             ..  |. ..|||   ||.. |  .    |. .. | | .      | |
pnseaeseefgpftvtlvneq.vyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvv

VHCSAGVGRSGVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCE
||||..|.|||| . .. .         |   ......| ..   ..|  |. .. .
VHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiyd
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 640-867 2.9e-32 106.8 In-house 37-265 (285) alignment 
Range on Protein: 640-867
Range on HMM: 37-265/285.0
PKNRYRDILPYDETRVKLF-KGSDYINANFVNMevPSHGIvLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQYWPEG-EDTWTFGN
  ||| |.   .|||| |  .  ||| |... |  | .     ||..|||| .|  |||.||.... . |.|| | .| |  ||  |.||   .   ||.
dlnryadvrcieetrvvlknhdrdyihaswmrm..pgkdq.styittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgk

LEVVCNKIRDFS-PSYVYREMYVTDTTTLRSRV--IIQLQYLAWPDHDVPDDATDFLEFVHSVRHYrEGTSTPAVVHCSAGVGRSGVLMFIETAFGMIEG
 |.   . .. .    ..  . |..|    |    . ..|   |||.  |.||  ..|. . |..  .   .| .|||||||||.  .. |. |   |  
yeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkv.npkekpicvhcsagvgrtatfvgidyatirime

AEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEA
   .  |..|| ||  |   .|.  ||||.   
npniemldivremramrfqavqshmqflflyvv
0044763 (Phosphotyrosine protein) phosphatases II 649-867 6.5e-32 106.0 In-house 1-166 (178) alignment 
Range on Protein: 649-867
Range on HMM: 1-166/178.0
PYDETRVKLFKGSD-----YINANFVNmevPShgivlRYIAAQGPlektcGDFWQMIWEQESTLVIMLTTTMERGRVKCHQYWPEGEDtwtfgnlevvcn
|.|.|||.|.. ..     ||||...    |       |.....|      |......|.  |....||...|.|..||..||||...            
pldrtrvllsnleglersdyinaseil...pg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag............

kirdfspsyvyremyvtdtttlrsrviIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREGTSTPAVVHCSAGVGRSGVLMfieTAFGMIEGaePVYPLEL
                           || ... .|||.|||    |||||. ......    | .|||||||||||.|.    |. |..    . . | 
...........................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlv...aaylmkkl..glsleea

VRRMRDQRGsLIQTPGQFLFVCEA
....| .|   ...|||  ...| 
ielvrerRp.ivpnpgqlrqLyef
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 641-864 1.7e-30 100.8 In-house 53-273 (301) alignment 
Range on Protein: 641-864
Range on HMM: 53-273/301.0
KNRYRDILPYDETRVKLFKGSDY--INANFVNMEvpshGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQYWPEG-EDTWTFGN
|.||  .    .| |....      | ||... .    |   |.||.||||..|. ||| |.   .   ..||. ..|.   ||..| |   ...   | 
khryptvPckPstavevivdGkrvPihanwipts....GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigr

LEVVCNKIRDF-SPSYVYREMYVTDTT-TLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHyregTSTPAVVHCSAGVGRSGVLMFIETAFGMIEGA
 ..  ..     . . . |.. |.|.|  . .| ..  ||  |.|..||   ..  .... |..    .  | |||||||.|||  ..  |     .|  
fkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkk....sekPivvhcsaGiGrsvafigteylarevead

EPVYPLELVRRMRDQRGSLIQTPGQFLFV
  .   | ....|..| . .||  |. ..
ptieltealkhlrehrwngvqtnsqlywm
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 637-865 1.9e-30 100.5 In-house 51-283 (310) alignment 
Range on Protein: 637-865
Range on HMM: 51-283/310.0
ENLPKNRYRDILPYDETRVKLF----KGSDYINANFVNMEVpshgIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQYWPEGEDT
... |||| |..  |..||||     .  ||| ||.|. .     .   .| .||||..|  |||.||... .  ...|  ..| || ||  |||    |
kymhknrysdvvcldtsrvklkidksryedyihanyvktny....lrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvt

WTFGNLEV-----------VCNKIRDFSPSYVYREMYVTDTTTLRSRVIiqlQYLAWPDHDVPDDATDFLE--FVHSVRHyregtsTPAVVHCSAGVGRS
 |.| . |           .||    | |  |  .   ..   ||  .|   ..  |||  |||.    .   ..  |||       | |||||||..| 
etygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvsli...kwpnwpdrgvpdekchtvpqrllaqvrh......gpcvvhcsagkdrl

GVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVC
.|.. .. ..  ..  . |   |..  .. .|   |||. |.|.. 
yvvvalklkidkldrglkvdaeevktellksraiciqtelqyliid
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 632-834 2.2e-30 100.3 In-house 31-229 (281) alignment 
Range on Protein: 632-834
Range on HMM: 31-229/281.0
DARKPENLPKNRYRDILPYDETRVKLFK------GSDYINANFVNMEVPSHGivlrYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQY
   .| |  |||| .|   | .||.|         .||| ||..   .  .|    || .||| ..|  |||.|||....| ..||   .|  | || .|
vfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrg....yiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaey

WPEGEDT-WTFGNLEVVCNKiRDFSPSYVYREMYVTDTTtlRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRhyreGTSTPAVVHCSAGVGRSGVLMF
.|        | .| |  .       | |   . ..      .|.| .  .  ||| .||. .  .|. .. .|      ||| |.|||||||||| || 
fprnahcclqfdklsvsyed.stvnkslvttrlnlsyeg..etrlithwlwkewpdwqvpessevmlkilrkir....arstppvihcsagvgrsgtlma

IETAFGMIEG
.| |.  |  
veialqsihs
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 638-866 3.9e-30 99.9 In-house 43-265 (288) alignment 
Range on Protein: 638-866
Range on HMM: 43-265/288.0
NLPKNRYRDILPYDETRVKLFKGSD-YINANFVNmevpSHGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQYWPE--GEDTwT
|  ..||...   | |||||   .| ||.|| |     |.    | | || ||. | . .|.|. |..   ..||.  .|.|. |  .|.|   || .  
nptrdryenlprcditrvklsddpdfyiaanvvs....sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGeka.r

FGNL-EVVCNKIRDFSPSYVYREMYVtdTTTLRSRV-IIQLQYLAWPDHDVPDDATDFLEFVHSVrhyrEGTSTPAVVHCSAGVGRSGVLMFIETAFGMI
.| |  || .|  |     .   . .  . .   .| . .| .| |.|. ||..   .| ... .    . .  | |||.||||||.| |..|  |  ..
igrlctvvkkkradidklvkvsllri..skegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgtlililialesl

EGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCE
   . .   .|. ..|..|   |||  |.|.|  
rlddflgirsllaklreerfkaiqtemqylyvhr
0051082 (Phosphotyrosine protein) phosphatases II 661-866 9.8e-29 95.3 In-house 3-147 (151) alignment 
Range on Protein: 661-866
Range on HMM: 3-147/151.0
SDYINANFVNMEvpshgivlrYIAAQGPLEktcgDFWQMIWEQESTLVIMLTTTMERGrvKCHQYWPEGEdtwtfgnlevvcnkirdfspsyvyremyvt
|||||...|            ... .|||.    ||.....|.  . ...|....|||  .|..|.|| .                              
sdyinfsyvtgg.........lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..............................

dtttlrsRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHyreGTSTPAVVHCSAGVGRSGVLMFIETAFgmiEGaepVYPLELVRRMRDQRGSLIQTPGQ
       . ......| |||...|.    .|||.. ...     . | .||||||.||.|.|. .       .|   | . | .. .| .|. ..|.. |
.......ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylml...lg...vsleealeeyrlkrpgvvqpnqq

FLFVCE
|||.  
flfqlf
FERM_C FERM C-terminal PH-like domain 238-325 4.9e-27 84.3 Pfam-A 1-87 (90) alignment 
Range on Protein: 238-325
Range on HMM: 1-87/90.0
DHDGTDLFLGVSALGLTVYHNKCKI--NFFPWSKIVKVCFKRKRFFIQIRPdwnEWTDNIIGFQMLTYRSCKNLWKVCVEYHSFYRTHYP
...||||.|||.| || .|... |.  . ||||.| |. ||.|.|.|..|    |  .. . |.. ..|..|.|.|.|.|.|...|.. .
nkkgtdllLGvdakGlliyeknsklsnksFpWseirklsfkekkftiklrd...ekkkdvlkFyssqlrvnklllklcienhdlfrrrrk
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 639-730 6.9e-27 89.1 In-house 48-154 (350) alignment 
Range on Protein: 639-730
Range on HMM: 48-154/350.0
LPKNRYRDILPYDETRVKLF-------------KGSDYINANFVNMEVPSHGIV--LRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCH
  ||||..||||. .||||              ...||||||.......|  |    .|||.|.|| .|  ||...| . . .....||. .| .. ||.
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

QYWPEGE
.||.||.
rYWqegs
PTPc_DSPc_SM00012 771-869 7.1e-27 89.0 In-house 3-104 (105) alignment 
Range on Protein: 771-869
Range on HMM: 3-104/105.0
IQLQYLAWPDHDVPDDATDFLEFVHSVRHYREGTS--TPAVVHCSAGVGRSGVLMFIETAFGMIEGA-EPVYPLELVRRMRDQRGSLIQTPGQFLFVCEA
 ...|..|||| ||......||....|.. ..  .  .| ||||||||||.|... ....  ..|   . |  ...|...|.|| ...||  |.||...|
khyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyra

TL
 |
ll
subfamily_CG42327_pd Subfamily CG42327 629-794 2.7e-23 77.1 In-house 19-187 (319) alignment 
Range on Protein: 629-794
Range on HMM: 19-187/319.0
AMDDARKPENLPKNRYRDILPYDETRVKLFKGS-----DYINANFVNMEVPSHGivlRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCH
|  |.  .   .|.|. ...|  |||| | . .      |..|..|     ..     ||||| .||..  |||...||| |  .. ||   | |  .| 
aradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapn...syiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvca

QYWPE---GEDTWTFGNLEVVcNKIRDFSPSYVYREMYVTDTTTLRSRVIIQLQYlAWPDHDVPDDATDFLEFV
.|.|    ...| ..|.. |   | |.    |.   . .       || .    |  |.. .|| . . ..  .
eylPtketldntslyGdilvt.lkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliaml
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 642-861 3.1e-23 77.0 In-house 47-265 (312) alignment 
Range on Protein: 642-861
Range on HMM: 47-265/312.0
NRYRDILPYDETRVKLFKGS-DYINANFVNMEVPSHgivlRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQYWpegEDTWTFGNLEV
||| .|  .|  |  |      || ||||..         |....|||||.||  |||.     || .|.|.. .| |  || .|     |  .| .|| 
nrypniqcwdrgrftlagdenfyihanfvkictkpe....rfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyi...sdivgfvdled

------VCNKIRDFSP---SYVYREMYVTDTTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYRegtsTPAVVHCSAGVGRSGVLMFIETAFGM
       | .|           .| . |   .| .   . . |. .|||| .||     | .. .|.. .     | . ||||||||.| |..||.    
hrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdk....kpviahcsagvgrtgtlaliesmiaa

IEGAEPVYPLELVRRMRDQRGSLIQTPGQF
.         .    .| .|   ...  |.
lrhprkqnvkdsfvllrkdrarsvrvfpqy
FERM_N FERM N-terminal domain 39-123 5.4e-23 71.1 Pfam-A 1-80 (80) alignment 
Range on Protein: 39-123
Range on HMM: 1-80/80.0
VELLDDSEFIIDVDKNAKGTVLLNEVFRHLDIQEKHYFGLQYVSDSPdnmvggAKEQWLQDDKIIRKQKKG-TPPYIFYFCVRFFV
|.|||.... ..||....|.|||..|...| ..|..||||..  |.        ...||..|| .|.| .  ..|......|.|.|
VrlLDgtvkevtvddsktgavlletVckrlglteteyFgLafkedkk......nesnwLdhdktlreqgveegkpttlllrvkfyv
0048076 (Phosphotyrosine protein) phosphatases II 729-868 5.5e-23 76.7 In-house 7-139 (145) alignment 
Range on Protein: 729-868
Range on HMM: 7-139/145.0
GEDTWTFGNLEVVCNkIRDFSPSYVYREMYVTDTTTLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREGTsTPAVVHCSAGVGRSGVLMfieTA
  . . .|.| .... .. .    ...   .|....| .| .||..|| ||||.|||.. ..|||.. ......    | .|||||||||.|.|.    |
ilpglylgslptald.lellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlv...aa

FGMIEgaEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEAT
. |..  . | . | ....| ||   ...|||. |..|. 
ylmll..lgvsleealelvrsqrpgavpnpgqlrflyefe
subfamily_egg_pd Subfamily egg 633-869 1e-22 75.2 In-house 35-267 (307) alignment 
Range on Protein: 633-869
Range on HMM: 35-267/307.0
ARKPENLPKNRYRDILPYDETRVKL-FKGS----DYINANFVNmevpSHGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERgrVKCHQYWP
| . .|| | | . .   | .|||| ..      |.| || |.     . ..  .| || ||  |  |||.|....|   ..|||.. |    .|. |||
aasdnnlekarskrvhckdssrvklelrrGqylddfihanrvk....Gkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywp

EGE-DTWTF--GNLEVVCNKIRDF-SPSYVYREMYVTDTTtlrsrviIQLQYLAWPDHDVpDDATDFLEFVHSVRHYREgTSTPAVVHCSAGVGRSGVLM
  | |.  .  |.|.. . |. .   | .   .. .  .         . ..|     || . ..|    .. .|. |.  |.|.||..  || ....|.
kaesdslvtvpGslrienlkvdskadplfrvtklklvGgd.......deerflehwqgdv.nnssdvysplrvlrklrn.lskpvvvqdilGvskaatlv

FIETAF-GMIEGAEPVYPL-ELVRRMRDQRGSLIQTPGQFLFVCEATL
 ||.|.  .. |    ... . |  .| .|   .... ..|||    |
aieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 637-864 3.3e-22 73.5 In-house 46-271 (303) alignment 
Range on Protein: 637-864
Range on HMM: 46-271/303.0
ENLPKNRYRDILPYDETRVKLFkGSDYINANFVNMEVPShgivlRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQYWPEGEDTWTFG
.|. |||. |..  | ..|||   | || |......        . | .| || .|. |||||| ||    |..| |  |  ..  .  .|. .|   | 
knmdknrfvdvicldhskvkls.dssyihasyleldssk.....kailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfe

NLEVVCN--KIRDFSPSYVYREMYVTDTtTLRSRVIIQlQYLAWPDHDVPDD-ATDFLEFVHSVRHYR--EGTSTPAVVHCSAGVGRSGVLMFIETAFGM
.  .     |  ...  .| . . |..  . .| . .. .| |||  ..| | .  |.  .  .. .      |||.|    .|.||.| . ..|||   
ersirvgefkrvelgdgwvlkvlsvsng.dyksflhvh.hykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahls

IEGAEPVypLELVR---RMRDQRGSLIQTPGQFLFV
.   ..   |.||.    .|. |   .|   || .|
lhseqas..ldlvkclenvrngrlhavqnlsqfsvv
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 638-867 9.7e-22 72.2 In-house 33-254 (267) alignment 
Range on Protein: 638-867
Range on HMM: 33-254/267.0
NLPKNRYRDILPYDETRVKLF-KGSDYINANFVNmevpSHGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMErGrvKCHQYWPEG-EDTWTF
|  .||. | ||||.||| |  |  .|||| .|.    ..     .|. |.||..| .||...| .|. . ...||.. . .  . ...||    ..  .
nqernrlddnlpyddtrvilrtkeeeyinasyve....gyktknafivtqdplkntitdfltvihdqkvpvivlltkvft.d..nirlfwPPkmgqakky

GNLEVVCNKIRDfSPSYVYREMYVtdTTTLRSRVIIQLQY-LAWpdhDVPDDATDFLEFVHS--VRHYREGTSTPAVVHCSAGVGRSGVLMFIETAFGMI
 .| |  .  ..    |    . .       |   . | |   |   ..  .   .|. .     .   |  . | ||.||.|||||| .. |.. .  .
qdltvehsleke.endyqiitlel..kfknesahnvtlyyykkw...nintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqlera

EGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEA
   . .   ...|..|.|| .|..|  ..... | 
ktegvsdifdflrkirsqriglvdtkeryiyihel
FERM_M FERM central domain 125-234 9.8e-22 67.6 Pfam-A 1-126 (126) alignment 
Range on Protein: 125-234
Range on HMM: 1-126/126.0
DPSKLVEDLTRYYFYLQIKRDILTGRLPCLYDTAAELSSYILQAELGDYD-PKLHLDGYVSE-F------RFIP--------DQTDDFEERAAEFHKHHI
||... .  .....|.|.|.|.|..||.|  ..|..| .. ||.|.||.. .. . .... .        ...|         .....|.| .| ||.. 
dpnpkydevrinllYeQakwdlleerldcteeeallLAALqlqiekgdseeeekasssdlekeeeeaeseqllpvsprllkkekskqleqrileahknva

GQTPADAEFNFLEVAKTLDLYGVDLH
|...|.|. ..|..|..|  |||.|.
glslaeaklkylqaaqslpdyGvslF
0048179 (Phosphotyrosine protein) phosphatases II 756-866 1.7e-21 71.9 In-house 48-139 (144) alignment 
Range on Protein: 756-866
Range on HMM: 48-139/144.0
EmyvtdtttlrsrvIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREgTSTPAVVHCSAGVGRSGVLMFIETAFgmiegAEPVYPLELVRRMRDQRGSLI
|             .||...| ||||.|||.....|||.. .....|  . | .|||||||||.|.|. .   .      . . . | ....| .|   .
e.............giqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgav

QTPGQFLFVCE
..|||. |..|
pnpgqlrfLle
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 692-869 8.8e-21 69.1 In-house 40-218 (255) alignment 
Range on Protein: 692-869
Range on HMM: 40-218/255.0
TCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQYWPEGED-TWTFGNLEVVCNKirdFSPSYVYREMYVTDTTT--LRSRVIIQLQYLAWPDHDVPDDAT
|   |.|.|  .... |.||.   | |..||..|.|   |    . ...|.. |    |   | | . .| | .   . . .   .|  |...  |..| 
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk...ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelar

DFLEFVHSVRHyregtSTPAVVHCSAGVGRSGVLMFIETAFG-MIEG---AEP--VYPLELVRRMRDQRGSLIQTPGQFLFVCEATL
. |. .. ||.     | . |||||.|.|||  ....| ..  ||     .|   .  |.|.. .| .| . |.|| |. |    .|
eilnilkvvrd.....sksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvl
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 661-865 3.5e-20 67.3 In-house 46-252 (290) alignment 
Range on Protein: 661-865
Range on HMM: 46-252/290.0
SDYINANFVNMevpSHGivLRYIAAQGPLEKT-------CGDFWQMIWEQESTLVIMLTTTMERGRV----KCHQYWPEGED-TWTFGNLEVVCnKIRDF
.||| ||.| .   ..|  || |. | |.||.         .|| |. . ... |.||   .|. .      | .| || ..   .|..|.| | | . .
ddyiHAnrvtc...png..lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkC.kskek

SPSYVYREMYVTDTTTlRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYregtSTPAVVHCSAGVGRSGVLMFIETAFGMIE-GAEPVYPLELVRRM
      ||. |.     .   .   ..  | .  |..|   .|. .. |. .     ||..|||  |. || .|  |. .. .|    . |   ...  .
eddvetRelvvkfdde.eeftvtHsllkgWnklnvqedtktllsliqkvkas....ktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkal

RDQRGSLIQTPGQFLFVC
| ||  .|... .. || 
rkqralaitsalelafvd
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 680-861 5.2e-20 66.4 In-house 5-193 (199) alignment 
Range on Protein: 680-861
Range on HMM: 5-193/199.0
LRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQYWPEGED-TWTFGNLEVVCNKIrDFSPSYVYREMYVTDTTTL--RSRVIIQLQYL
 ||||.| || .|  |||||.||  |  ..|.        .    |||  |  |  .|.| |... |    | |.   . .|. ||    .| | . |. 
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttkti.ttkpdytitaliltnnttappstreishyqft

AWPDHDVPDDATdFLEFVHSVR----HYREGTSTPAVVHCSAGVGRSGVLMFIETAFGMIEGAE--PVYPLELVRRMRDQRGSLIQTPGQF
.| ..  |. |  |. || . |    .| .   .| .|||| | | .||.. ..      | .    |  .|. .|.|. |  .| .  ..
swkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 681-861 6.3e-20 66.2 In-house 5-192 (198) alignment 
Range on Protein: 681-861
Range on HMM: 5-192/198.0
RYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQYWPEGED-TWTFGNLEVVCNKIrDFSPSYVYREMYVTDTTTL--RSRVIIQLQYLA
||||.| || .|  |||||.||  |  ..|.        .    |||  |  |  .|.| |... |    | |.   . .|. ||    .| | . |. .
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttkti.ttkpdytitaliltnnttappstreishyqfts

WPDHDVPDDATdFLEFVHSVR----HYREGTSTPAVVHCSAGVGRSGVLMFIETAFGMIEGAE--PVYPLELVRRMRDQRGSLIQTPGQF
| ..  |. |  |. || . |    .| .   .| .|||| | | .||.. ..      | .    |  .|. .|.|. |  .| .  ..
wkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhy
FA FERM adjacent (FA) 330-375 2e-19 58.2 Pfam-A 1-46 (47) alignment 
Range on Protein: 330-375
Range on HMM: 1-46/47.0
KRVLRMGSKYRYKGKTEYQAIEESRTHARPEPKIVRTLSRRYSKRS
......|||.||.|.||.|.||||| . |. |.. |..|.||..|.
skffslGSkFRYSGRTekQvieesreigrkppsfeRspskrylsrr
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 609-869 4.3e-19 63.0 In-house 23-282 (302) alignment 
Range on Protein: 609-869
Range on HMM: 23-282/302.0
LESGDLLVYFQELYRKKPGMAMDDARKpENLPKNRYRDILPYDETRVKLF-KGSDYINANFVnmEVP--SHGIVLRYIAAQGpLEKTCGDFWQMIWEQES
|... .   |...   |  . .  | | .|| ||.  |.  .|...|||  .  .|.||  |  |||  .. |.|  .. ..  |.   .||.|..... 
ldtaevkkefkkidtmkvdlekCkafk.knlkknqsedvpildsnlvkleaepdsyvnaskv..evPeltrsiilaQlpkvd.sedsveeFWrmvfqeki

TLVIMLTTTMERGRvKCHQYWP-EGEDTWTFGNLEVVCNKIRDFSPSY--VYREMYVTDTTtlrSRVIIQLQ-YLAWPDHDVPDDATDFLEFVHSVRHYR
. | .|  . |  .   ....| . .|  ..|.. |   |.   . .    . |.   . .     |.....    |... ||.  ..  . ...| .  
vsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcs...nsvlanvyvltnWkqkkvpvkyaeliktaakvfakk

EGTSTPAVVHCSAGVGRSGVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATL
. .. ..|.    |.|| |...   .|.  ..  . .   |.|. .| || . ...  |. ..  |.|
ikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiall
PDZ PDZ domain (Also known as DHR or GLGF) 459-541 4.9e-18 55.2 Pfam-A 2-79 (81) alignment 
Range on Protein: 459-541
Range on HMM: 2-79/81.0
VRMEPDKEGRFGFNVQGGADIN-LPVIVSKIARGtPADLCMPqLQEGDEIIFINGQAMKGLIHQEIVDLIRSVSQsrsnTLILT
|..|..|.|..||...|| | .  ...||.. .| .|. . . |.||| |. .||. . .. | |.|..|.. ..    .. ||
vslekekrgglGfslkggsdkrdkgifvsevvpg.gaaeadg.lkeGDkIlsvNgvdvenvshdeavqaikgkkg....evtLt
subfamily_hpo-7_pd Subfamily hpo-7 690-869 9.9e-18 59.0 In-house 44-224 (263) alignment 
Range on Protein: 690-869
Range on HMM: 44-224/263.0
EKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQYWPEGED-TWTFGNLEVVCNKIRDfspSYVYREMYVTDTTT--LRSRVIIQLQYLAWPDHDVPDD
 .|   |.|.|  .... |.||.   | |..|| .|.|   |    . |..|.. |. .     . .   .. |     . . . . .|  |...  | .
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs...dvllktlellstlgeKkkthtvkhysykgWiekndpel

ATDFLEFVHSVRHYREgtstpAVVHCSAGVGRSGVLMFIETAFG-MIEG---AEPV--YPLELVRRMRDQRGSLIQTPGQFLFVCEATL
| . |. .. .|. ..      |||||.|.|||    ..|...  ||     .. |    |.|.. .| .| . |.|| |. |    .|
areilnilkvarnsks.....lvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvL
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 687-865 9e-17 55.5 In-house 98-281 (302) alignment 
Range on Protein: 687-865
Range on HMM: 98-281/302.0
GPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQYWPE-GEDTWTFGNLEVVCNKIR----DFSP---SYVYREMYVTDTTTLRSR-VIIQLQYLA
 |  .|.  .| .| . . ..|. |.. .| .  || .|. .  ... .||.  |   ...    .|.      .|   .  . .. . .  .  |.. |
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPDHDVPDDATDFLEFVHsvrhYREGTSTPAVVHCSAGVGRSGVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVC
||||  |..|   |. ..    . |   .  .|||||||||.| |. |     .    .    |..|  .|. |   .|.  | ... 
wpdhGapkeaytaldilk....fcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyll
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 764-871 1.4e-15 51.6 In-house 85-193 (440) alignment 
Range on Protein: 764-871
Range on HMM: 85-193/440.0
TLRSRVIIQLQYLAWPDHDVPDDATDFLEFVHSVRHYREGT-STPAVVHCSAGVGRSGVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFL
 . ||.. | .| .|||. ||  |   |.... | . .| . . | .||||||.||.||.. ... .   . .. .  . ..  ||..|  ..||| |. 
giesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqya

FVCEATLKA
|| || |..
fvheavleg
subfamily_eak_pd Subfamily eak 620-795 4.7e-15 49.8 In-house 34-205 (332) alignment 
Range on Protein: 620-795
Range on HMM: 34-205/332.0
ELYRKKPGMAMDDARKPENLPKNrYRDILPYDETRVKLFKG----SDYINANFvnMEVPShgIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTM
.| .... ...  ... |.. .|   .|.|||   |.|         ||||    .| .   .  .|| .  . |.    ||||. || |  ...|   .
dlddyqrllsisetarleavnrn.vvkivpydrylvrltssqlnrlGyinasl..aefse..vGrkyiltGiasedkvfafwqmvleqkspaivqlledv

ERGRVKCHQYWPEGE-DTWTFGNLEVVCNKIrDFSPSYVYREMYVTDTTTlrSRVIIQLQYLAWPDHDVPDdATDFLEFVH
| .  |  .|.|.   . . || |.| . .       . .| . ..      .  .   ..  | . ..|    ||| . .
elkleksdkyfpdktreelkfGildverkef.vkrniletrllelskGne..thrvlhykvfGwtettlpk.yedflalrk
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 619-731 1.1e-13 45.3 In-house 78-183 (244) alignment 
Range on Protein: 619-731
Range on HMM: 78-183/244.0
QELYRKKPGmAMDDARKPENLPKNRYRDILPYDETRVKLFKGS---DYINANFVNmevpSHGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTM
|.. |  |   | || .|.|  |||    ||.|  || | |||    |||| ||       |    || .| ||  |  |||.|. |.   ....| .  
qniirpdps.vmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvg....clgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsve

ERgrvkcHQYWPEGED
|       .|||. | 
ee.....deywpdsep
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 661-730 1.2e-11 38.6 In-house 90-157 (349) alignment 
Range on Protein: 661-730
Range on HMM: 90-157/349.0
SDYINANFVNMevPSHGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVKCHQYWPEGE
 ||||||....  .   .  .||| | ||  |  ||...|  ..  ||. |.   | .  ||..|| |..
ddyinanylkl..trisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqels
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 805-870 2e-09 31.7 In-house 228-293 (297) alignment 
Range on Protein: 805-870
Range on HMM: 228-293/297.0
STPAVVHCSAGVGRSGVLMFIETAFGMIEGAEPVYPLELVRRMRDQRGSLIQTPGQFLFVCEATLK
... .||||||||||||..  ..   ..          ... .|.||  |.||  || .. .|.||
nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 768-869 3.3e-09 30.9 In-house 215-341 (350) alignment 
Range on Protein: 768-869
Range on HMM: 215-341/350.0
RVIIQLQYLAWPDH---DVPDDATDFLE-------FVHSVRHYREGTSTPAVVHCSAGVGRSGVLMFIETAFG------MIEG--------AEPVYPL-E
 |. |||.  |.|      | .    ||          .  |. .  |.| .||||||||| |.|. ..  .       ...         |.   ..  
yvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisi

LVRRMRDQRGSLIQTPGQFLFVCEATL
.| ..| || |..|.  ||.|. || |
ivnelrkqrismvqnldqfifiYeall
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 637-687 1.7e-08 28.6 In-house 47-95 (95) alignment 
Range on Protein: 637-687
Range on HMM: 47-95/95.0
ENLPKNRYRDILPYDETRVKLF--KGSDYINANFVNMEVPSHgivlRYIAAQG
 |.||||. .|.||| ||| |   . |||||| ||.           ||||||
anipknrflnifpydatrvvlttkrdsdyinacfvdgyarkn....cyiaaqg
subfamily_CG42327_pd Subfamily CG42327 801-866 7.1e-08 26.5 In-house 243-309 (319) alignment 
Range on Protein: 801-866
Range on HMM: 243-309/319.0
REGTSTPAVVHCSAGVGRSGVLMFIETAFGMIEGA-EPVYPLELVRRMRDQRGSLIQTPGQFLFVCE
..    | ||||| ||||.|...  . |.  .| . . |   .||  .| .|.| ..|  |. |.  
tresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiyk
0038934 (Phosphotyrosine protein) phosphatases II 771-861 8.2e-08 27.6 In-house 80-166 (194) alignment 
Range on Protein: 771-861
Range on HMM: 80-166/194.0
IQLQYLAWPDHDV-PD--DATDFLEFVHSVRhyREGTSTPAVVHCSAGVGRSGVLMfietAFGMIEGaEPVYPLELVRRMRDQRGSLIQTPGQF
|.   | .||. . |.    ..||..|. .   .| ..   .||| ||.||.|.|     |  .|.      . | ....|. |.. |......
ieylklpfpddgtvPsleillrfldlvdefl..nedpggvvaVHCkaGlgRtGtlv....aaYLiyr.lgmsaeeAialfrekRpgaipnqdyl
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 648-731 4.5e-07 24.2 In-house 3-74 (130) alignment 
Range on Protein: 648-731
Range on HMM: 3-74/130.0
LPYDETRVKlfkGSDYINANFVNMevpsHGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERgrvkcHQYWPEGED
|... .|..   | .||||.|| .     |    |. .| || .|. |||.|. |.   ....| .  |       .|||. | 
lefevsrlq...gntyinasfvGl....lgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdseP
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 770-833 1.1e-06 22.2 In-house 220-293 (349) alignment 
Range on Protein: 770-833
Range on HMM: 220-293/349.0
IIQLQYLAWPDHDVPDDAT----------DFLEFVHSVRHYREGTSTPAVVHCSAGVGRSGVLMFIETAFGMIE
..|||.  |.|  .  .            |...  ..  .. .  ... .|||||| ||.|||. ..  . ..|
llqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsile
PTEN_1 772-822 3.7e-06 21.9 In-house 96-147 (196) alignment 
Range on Protein: 772-822
Range on HMM: 96-147/196.0
QLQYLAWPDHDVPDDATDFLEFVHSVRHYREGT-STPAVVHCSAGVGRSGVL
.   . ..|| .|. .  | . .     ...      ..||| ||.||||..
eylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtv
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 682-740 9.1e-06 19.2 In-house 238-293 (440) alignment 
Range on Protein: 682-740
Range on HMM: 238-293/440.0
YIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERgrvKCHQYWPEGEDTWTFGNLEV
.||.| ||. |  |||... . . . .|||    ..    |  |||    . ||| . |
fiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpftv