Gene PTPN5_RR in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN5_RR
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP077_AA protein Get Run
NvecP077_AA_41-319 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 54-320 5.6e-126 414.2 In-house 2-270 (274) alignment 
Range on Protein: 54-320
Range on HMM: 2-270/274.0
DNTKQLYAEFWEIPMNHPPAEERLPGSSYRNRYPSILPNSRTRVSL-PQIPDDPLSSYINANVLKGYGEEINAFIATQGPLSCTVNDFWRMIWYHHCPII
...|.|..||.|.|.|....|....||...||| .||||...||.| .. ..|..|||||||..|||.|| .|..||||||..||.||||||.......|
rsfkdlekeflelPlnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvi

VMITKLKERNETKCERYWPDPT-FRMQEKYGDIVVTFDSALGRDGYQITSLYISHSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRDDGKT
||.|||||.||.||..|.|| . ....|.|||. ....... |..|....|........|...|||||.|||| .||....||.||.||. ...... |.
vmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenakl

GPVVVHCSAGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYHHWRQ
.||||||||||||||||.|.||...|...|..||.||||| .|..|||||.|..|||...|||......
apvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkr
subfamily_PTPRD_pd Subfamily PTPRD 59-316 4.9e-89 294.5 In-house 25-279 (564) alignment 
Range on Protein: 59-316
Range on HMM: 25-279/564.0
LYAEFWEIPMN--HPPAEERLPGSSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGeEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMIT
.  |. .| ..  ..  . . |    .|||  |..  ..|| | ... |. | ||||. ..||  . .|.|||||||. |..|||||.| ... .|||.|
feeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPlaetiedFWRmvweqnsstiVmlt

KLKERNETKCERYWPDPtfRmQEKYGDIVVTFDSALGRDGYQITSLYIS--HSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQdRddGKTGPV
||.|....||..|||.   . .|.||...||. .      |.|... ..  .|.. |   .. .|.|||||||.|...||.|...|. .. .   ..||.
kleEkgkvkchkYWPek..g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.e..pdagPi

VVHCSAGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYH
|||||||.||||.|.. .. ...|..|..||| ..|  .| .|  ||.| .|| |...|...
vVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheaile
0051299 (Phosphotyrosine protein) phosphatases II 53-318 5.6e-87 287.1 In-house 19-286 (288) alignment 
Range on Protein: 53-318
Range on HMM: 19-286/288.0
VDNTKQLYAEFWEIPMNHPPA---EERLPGSSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEINaFIATQGPLSCTVNDFWRMIWYHHC
 .....|..|| |.. . |.      .||    .|||..|||. ..|| |  ..... |.||||. ..||  .   ||||||||. ||.|||||.| ...
angltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk.fIatqgPlpntvedFWrmvweqnv

PIIVMITKLKERNETKCERYWPDptfRMQEKYGDIVVTFDSALGRDGYQITSLYIS------HSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLA
..|||.||| |.. .||..|||.   .  ..||||.||. |    |.| .. |...       .. .|. .|..||.||||||||||..||... .|. |
rvIvmltklvelgrekcaqYwpl...ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrka

QDrddGKTGPVVVHCSAGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYHHW
.     . ||||||||||.||||.|.|  . . |..||..||.|..|. .|. | |||.| .||.|||.||....
la...sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0050432 (Phosphotyrosine protein) phosphatases II 47-318 1.1e-86 286.2 In-house 32-299 (308) alignment 
Range on Protein: 47-318
Range on HMM: 32-299/308.0
EELGECVDNTKQLYAEFWEIPMNHPPAE---ERLPGSSYRNRYPSILPNSRTRVSLpqipdDPLSSYINANVLKGYG-EEINAFIATQGPLSCTVNDFWR
 .| |  .....|..||.|.... |. |    .||    .|||..|||. ..|| |     |. |.||||.  .||     ..||||||||. ||.||||
lkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwr

MIWYHHCPIIVMITKLKERNETKCERYWPDPTFRMQEKYGDIVVTFDSALGRDGYQITSLYISH--SQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEV
|.| .....|||.||| |..  ||..|||. . .  ..||...||. |   .|.| .. |....  ..  |...|..||.|||||||.||..||.....|
mvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelv

HLAQdrddgKTGPVVVHCSAGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYHHW
.  .     . ||.|||||||.||||.|.|  . . |..||..||....|. .|. | |||.| .||.|.||||....
rksl.....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleyl
0046845 (Phosphotyrosine protein) phosphatases II 59-318 3.2e-86 284.5 In-house 2-274 (284) alignment 
Range on Protein: 59-318
Range on HMM: 2-274/284.0
LYAEFWEIPMNHPP-----AEERLPGSSYRNRYPSILPNSRTRVSLPQIPDD-PLSSYINANVLKGYG----EEINAFIATQGPLSCTVNDFWRMIWYHH
|..||.|.... ..        .||    .|||..|||. ..|| |  ...| . |.||||. ..||.       ..||||||||. ||.|||||.| ..
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

CPIIVMITKLKERNETKCERYWPDPtfRMQEKYGDIVVTFDSALGRDGYQITSLYISH---SQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQD
...|||.|.| |.. .||..|||.       .|||. ||. |   .|.| .. |....   .. .|...|..||.|||||||.||..||.....|. ...
vrvIVmltelvengrekcaqYwple..gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrelle

RdDGKTGPVVVHCSAGIGRTGCFVATSIGIKQIQKEN---KVDILKIVCGMRMERGGMVETDSQYEFVYRALYHHW
.  .. ||.|||||||.||||.|.|  . ..|..||.   .||.|..|. .|. | |||.| .||.|||.||....
n.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleyl
0039614 (Phosphotyrosine protein) phosphatases II 40-319 7.5e-85 280.2 In-house 15-290 (297) alignment 
Range on Protein: 40-319
Range on HMM: 15-290/297.0
KSKLITFEELGECVDNTKQLYAEFWEIPMNH-PPAEERLPGSSYRNRYPSILPNSRTRVSLPQIPD-DPLSSYINANVLKGYGEEINAFIATQGPLSCTV
. . ...  | |  ... .|..||.|.. .  .  . .|| .  .|||..|||. ..|| |  ... |. |.||||. ..||    ..||||||||. ||
plsvldlllllekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetv

NDFWRMIWYHHCPIIVMITKLKERNEtKCERYWPDPTFrmqeKYGDIVVTFDSALGRDGYQITSLYISHSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLV
.|||||.| .....|||.|||.|..  ||..|||. .     .|||..||. .   .||| .. | ..... .| ..|..|| |||||||.|...||...
edFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg....tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslelllefl

DEVHLAQDRDdGKTGPVVVHCSAGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYHHWR
..|. |. .. .| |||.||||||.||||.|.|  . . |..|| .||.|..|. .|. |.|.|.|.|||.|.|.||.....
elvrealael.pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk
DSPc_SM00195 71-316 2.6e-82 271.5 In-house 17-260 (263) alignment 
Range on Protein: 71-316
Range on HMM: 17-260/263.0
PPAEERLPGSSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYgEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYW
.  |.. . .. .|||  |||. .||| |....... |.|||||..||. .. ...|||||||. ||.|||||.| ....||||.|. .|....||.|||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdryw

PDPTfRMQEKYGDIVVTFDSALGRD-GYQITSLYISHSQ--SPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRDdgkTGPVVVHCSAGIGRTGC
|.     .|..|.| |.. .   ..  .... | ... .   .|....|.|..|||||||||....|.|. .|.  ...    .||.|||||||.||||.
pees.ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts...sgpivVhCsaGvgRtgt

FVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYH
||...| ......|.|||| .||. .|..| |||.|. || |.|.|. .
fvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
PTPc_SM00194 71-316 2.6e-82 271.5 In-house 17-260 (263) alignment 
Range on Protein: 71-316
Range on HMM: 17-260/263.0
PPAEERLPGSSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYgEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYW
.  |.. . .. .|||  |||. .||| |....... |.|||||..||. .. ...|||||||. ||.|||||.| ....||||.|. .|....||.|||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdryw

PDPTfRMQEKYGDIVVTFDSALGRD-GYQITSLYISHSQ--SPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRDdgkTGPVVVHCSAGIGRTGC
|.     .|..|.| |.. .   ..  .... | ... .   .|....|.|..|||||||||....|.|. .|.  ...    .||.|||||||.||||.
pees.ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts...sgpivVhCsaGvgRtgt

FVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYH
||...| ......|.|||| .||. .|..| |||.|. || |.|.|. .
fvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
0040438 (Phosphotyrosine protein) phosphatases II 57-318 6.1e-82 270.7 In-house 18-276 (317) alignment 
Range on Protein: 57-318
Range on HMM: 18-276/317.0
KQLYAEFWEIPMNHPP--AEERLPGSSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEINaFIATQGPLSCTVNDFWRMIWYHHCPIIVM
..|. ||.... ....   . .|| .  .||||.|||. ..|| |  .. |. |.||||.  .|. .  . ||||||||. ||.|||||.| ... .|||
talleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrk.fIatqgPlpntvedFwrmvweqgvtvivm

ITKLKERNETKCERYWPDptfRMQEKYGDIVVTFDSALGRDGYQITSLYISH--SQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDrddGKTG
.|.|.|..  ||..|||.   .   .|||..||. |    .|.... | ...  .. .|...|..||.|||||||.||..||.....|. |..   .. |
LteleelgrekcaqYwpl...getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale...dpgg

PVVVHCSAGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYHHW
||.||||||.||||.|.|  . . |..||..||. ..|. .|. |.|.|.| .||.|.|.||....
pvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
0047943 (Phosphotyrosine protein) phosphatases II 54-316 6.5e-82 270.3 In-house 9-270 (273) alignment 
Range on Protein: 54-316
Range on HMM: 9-270/273.0
DNTKQLYAEFWEIPMNHPPA---EERLPGSSYRNRYPSILPNSRTRVSLpqipDDPLSSYINANVLKGYGEEINaFIATQGPLSCTVNDFWRMIWYHHCP
.....|..|| ... . |.      .||    .|||..|||. ..|| |    .|. |.||||. ..||  . . ||||||||. ||.|||||.| ....
lgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrk.fiatqgPlpntvedfwrmvweqnvr

IIVMITKLKERNETKCERYWPDPTFRMQEKYGDIVVTFDSALGRDGYQITSLYISH--SQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRDD
.|||.|.| |..  ||..|||.    . ..||.. ||. |   .|.| .. |....  .. .|  .|..|| |||||||.|. .||.....|. |.  . 
viVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealp

GKtGPVVVHCSAGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYH
.. ||||||||||.||||.|.|  . . |..||..||.|..|. .|. | |||.| .||.|.|.||..
sn.gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
0036941 (Phosphotyrosine protein) phosphatases II 57-318 6.2e-81 267.3 In-house 16-277 (297) alignment 
Range on Protein: 57-318
Range on HMM: 16-277/297.0
KQLYAEFWEIPMNHPPAEERLPGSSYRNRYPSILPNSRTRVSLpqipDDPLSSYINANVLKGYGEEINaFIATQGPLSCTVNDFWRMIWYHHCPIIVMIT
.. . |....  . .    .||.   .|||..|||. .||| |    ||. |.||||. ..||. . . ||||||||. ||.|||||.| .....|||.|
lkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrk.fIatqgPlpntvedFWrmvweqnvtvIvmlt

KLKERNETKCERYWPDPTFRMQEkYGDIVVTFDSALG--RDGYQITSLYISH--SQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQdRDDGKTG
.| |..  ||..|||. .   .. |||..||. |      |.| .. | ...  .. .|...|..|| |||||||.||..||.....|. .. .   . |
elvelgrekcaqywpleegeslt.ygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvl.kllpsgg

PVVVHCSAGIGRTGCFVATSIGIKQIQ---KENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYHHW
||.||||||.||.|.|.|  . . |..   ||..||||..|. .|. | |.|.| .||.|.|.||....
pvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
0045450 (Phosphotyrosine protein) phosphatases II 55-318 1.5e-79 263.3 In-house 25-304 (307) alignment 
Range on Protein: 55-318
Range on HMM: 25-304/307.0
NTKQLYAEFWEIPM-----NHPPAEERLPGSSYRNRYPSILPNSRTRVSLPQIPDD-PLSSYINANVL--------KGYGEeINAFIATQGPLSCTVNDF
.   |..|| ...      ...  . .|| .  .|||..|||. .||| |  .... . |.||||.          .||    ..||||||||. ||.||
fltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydl.krkfIatqgPlpetvedF

WRMIWYHHCPIIVMITKLKERNETKCERYWPDPtfRMQEKYGDIVVTFDSALGRDGYQITSLYIS---HSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLV
|||.| ... .|||.|.|.|..  || .||||   . .  ||...||. |    |||... | ..    .. .|...|..||.|||||||.|. .||...
wrmlweqgvtvivmltelvelgrekcaqywPde..geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfi

DEVHLAQDRDdGKTGPVVVHCSAGIGRTGCFVATSIGIKQIQKENK---VDILKIVCGMRMERGGMVETDSQYEFVYRALYHHW
.||. |.... .| |||.||||||.||||.|.|  . ..|..||..   ||.|..|. .|. |.|.|.. .||.|.|.||....
eevrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
0043336 (Phosphotyrosine protein) phosphatases II 61-318 2.3e-79 262.1 In-house 27-277 (278) alignment 
Range on Protein: 61-318
Range on HMM: 27-277/278.0
AEFWEIPMnHPPAEERLPGSSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEINaFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKE
 |.....   .    .|| .  .|||..|||. ..|| |  .. |. |.||||. ..||    . ||||||||. ||.|||||.| .....|||.|.|.|
eellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprk.fiatqgPlpetvedFwrmvwelgvttivmLtelve

RNETKCERYWPdptfRMQEKYGDIVVTFDSALGRDGYQITSLYIS--HSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDrddGKTGPVVVHC
.. .|| .|||    .  ..|||..||. .    |.| .. | ..   .  .|  .||.|..|||||||.|. .||... .|. |..    . |||.|||
lgrvkcaqYwp....ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale...dsngpvlVHC

SAGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYHHW
|||.||||.|.|  . . |..|| .||....|. .|. |.|.|.|.|||.|.|.||....
saGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_PTPRB_pd Subfamily PTPRB 60-319 7.7e-79 259.8 In-house 31-286 (293) alignment 
Range on Protein: 60-319
Range on HMM: 31-286/293.0
YAEFWEIPMNHPPAEERLPGSSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLK
| |. .. ...  .  .|.  . .|||  |||   .|| | .. |.. | ||||| ..||  . . ||||||||  ||.|||||.| ... ||||.|.| 
yeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsp.refiatqGPlpetvddfWrmvwekkssiivmltqlv

ERNETKCERYWPDPtfRMQEKYGDIVVTFDSALGRDGYQITSLYISHSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDrDDGKTGPVVVHCS
|.  .|||.|||.   . .  |||| ||. .    . . | .| |..... |.. .| .|.|||||||.....||..| .|. |.. .. ...|.|||||
ekgkvkCeeYWPad..eepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvreaie.ktaskrPivvhCs

AGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYHHWR
||.|||| |.|    ...|..|. |||. ||. .|.||  .| | .|| |..... . .|
aGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 81-318 1.7e-78 258.4 In-house 21-264 (270) alignment 
Range on Protein: 81-318
Range on HMM: 21-264/270.0
SYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTFR-MQE
.  |||  |||. .||| |... .|. . ||||| ..|. .| ...||..|||  |...|||||| .. . |||.|.|.|.. .|||||||  . . .. 
kklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkl

KYGDIVVTFDSALGRDGYQITSLYISHSQSPRRLYHYWYTAWPDHGVPDSPR------QLLQLVDEVHLAQDRDDGKTgPVVVHCSAGIGRTGCFVATSI
..|.| |.  |   ..|| .| | . .. . ||| |.||..||||||| ..       |||... .|.  ... | .. |..||||||.||||...|. |
edgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae.PllvHcsaGvgRtGtlialDi

GIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYHHW
... .....|||.|.|.  .| .|  .|..  ||||.|.|. .. 
avrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveya
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 76-315 5.1e-78 257.3 In-house 42-277 (318) alignment 
Range on Protein: 76-315
Range on HMM: 42-277/318.0
RLPGSSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDptf
  |   ..|||  ||.  .||| | .. ... | ||||| . || .. .|.||.|.||. |..|||||.|  .. .|||.|...||  .|..||||.   
lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrk.kayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPs...

RMQEKYGDIVVTFDSALGRDGYQITSLYISHSQ--SPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRDDgkTGPVVVHCSAGIGRTGCFVATSI
.  ..||..||. .. .  . | . .. .....  . |    | ||.|||.|||.|. .||.|| .|. || . .  .||.|||||||.|||| |.| .|
kgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksg..agpivvhCsaGvGrtGvfiavdi

GIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALY
 ...|..|. ||....|  .| .|  || |..||||.| .| 
llerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvll
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 78-316 1.2e-76 252.9 In-house 46-281 (319) alignment 
Range on Protein: 78-316
Range on HMM: 46-281/319.0
PGSSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTFrm
.  . .|||. ||.  |||| |..... . | ||||. . || |. ..|||||.||. |..|||||.| ... |.||.|||.|. . |...|||. .|  
eenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqer.ekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenf..

qEKYGDIVVTFDSALGRDGYQITSLYISHSQS---PRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRDdgKTGPVVVHCSAGIGRTGCFVATSIG
 |.|| ..|| ..    ..| |  | . . .|    |.. |. ||.||||.||.. ..||.|. ... ....   . ||.|||||||.|||| |.. .. 
.eeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrekt..qsgPivvhCsaGvGRtGtfivldam

IKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYH
. ....|. .|. ..|  .|. |  ||.. .||.|.| || .
lervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealle
Y_phosphatase Protein-tyrosine phosphatase 82-315 2e-76 251.9 Pfam-A 3-234 (235) alignment 
Range on Protein: 82-315
Range on HMM: 3-234/235.0
YRNRYPSILPNSRTRVSLpqiPDDPL-SSYINANVLKGYGeEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTfRMQEK
 .|||..|||  .||| |    ...  | |||||..|||  | ..||||||||. |..|||||.| ... .|||.|.|.|....||..|||. . . ...
kknRykdilpydktrvkl...kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeee.eeslt

YGDIVVTFD-SAL-GRDGYQITSLYISHSQSPR---RLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQdrdDGKTGPVVVHCSAGIGRTGCFVATSIGI
|||| |.   .     ..|... | ........   ......||.|||||||.||..||.|...|.  .   . |.||||||||||.||||.||| .| .
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldill

KQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALY
.|...|..||.|.||. .| .| |||.. .||.|.|.|. 
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 82-315 2e-76 251.9 In-house 3-234 (235) alignment 
Range on Protein: 82-315
Range on HMM: 3-234/235.0
YRNRYPSILPNSRTRVSLpqiPDDPL-SSYINANVLKGYGeEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTfRMQEK
 .|||..|||  .||| |    ...  | |||||..|||  | ..||||||||. |..|||||.| ... .|||.|.|.|....||..|||. . . ...
kknRykdilpydktrvkl...kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeee.eeslt

YGDIVVTFD-SAL-GRDGYQITSLYISHSQSPR---RLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQdrdDGKTGPVVVHCSAGIGRTGCFVATSIGI
|||| |.   .     ..|... | ........   ......||.|||||||.||..||.|...|.  .   . |.||||||||||.||||.||| .| .
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldill

KQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALY
.|...|..||.|.||. .| .| |||.. .||.|.|.|. 
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
0040439 (Phosphotyrosine protein) phosphatases II 75-318 5.3e-76 250.8 In-house 6-246 (249) alignment 
Range on Protein: 75-318
Range on HMM: 6-246/249.0
ERLPGSSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEINaFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDpt
 .|| .  .||||.|||. ..|| |  .|. .||.||||....||    . ||||||||. ||.|||||.| ... .|||.|.|.|..  ||..|||.  
allpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr.fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..

fRMQEKYGDIVVTFDSALGRDGYQITSLYIS--HSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRDdGKTGPVVVHCSAGIGRTGCFVATS
 .   .|||..||. |    |.| .. |...    ...|. .|..|| |||||||.|. .||.....|. |.... .| |||.||||||.||||.|.|  
.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel.pkggpvlVHCsaGvgRtGtfiaay

IGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYHHW
. . |..||..||.. .|. .|. |.|.|....||.|.|.||....
lmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0045098 (Phosphotyrosine protein) phosphatases II 74-319 1.8e-74 245.9 In-house 27-273 (278) alignment 
Range on Protein: 74-319
Range on HMM: 27-273/278.0
EERLPGSSYRNRYPSILPNSRTRVSlpqipddplsSYINANVLKGYgEeiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDp
.  ..|. ..|||..|||. ..||            ||||. ..||    ..||||||||  ||.|||||.| .....|||.|.|.|..  ||..|||. 
palylgnldknRykdilpydhsrVk..........dYINAsyidgy.p..kkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe.

tfRMQEKYGDIVVTFDSALGRDGYQITSLYISHS------QSPRRLYHYWYTAWPDHGVPDSP--RQLLQLVDEVHLAQD----------RDDGKTGPVV
  .  . |||..||. |    | | .. |.. .         .| ..|..|. |||||||..|  ...|.|..... |..          . ... |||.
..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvl

VHCSAGIGRTGCFVATSIGIKQIqkENKVDILKIVCGMRMERGG-MVETDSQYEFVYRALYHHWR
||||||.||||..||  . ....  |..||.|..|. .|. |.| .|.. .||.|.|..|.....
VHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
0042113 (Phosphotyrosine protein) phosphatases II 77-317 4.3e-74 244.3 In-house 6-242 (245) alignment 
Range on Protein: 77-317
Range on HMM: 6-242/245.0
LPGSSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEeINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDptfR
|| .  .|||..|||. .||| |. .. |. |.||||.  .||    . ||||||||. ||.|||||.| ... .|||.|.. |..  ||..|||.   .
lpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyri.tpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl...g

MQEKYGDIVVTFDSALGRDGYQITSLYIS--HSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRddGKTGPVVVHCSAGIGRTGCFVATSIG
   .|||..||. |    |.| .. | ..   .  .|  .||.|. ||||||||....||.....|. |. .  .. |||.||||||.||||.|.|  . 
esltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae..dsngpvlVHCsaGvgRtGtfiaaylm

IKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYHH
. |..|| .|.. ..|  .|. |.|.|.|.|||.|.|.||...
leqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 75-315 6e-73 240.4 In-house 42-276 (288) alignment 
Range on Protein: 75-315
Range on HMM: 42-276/288.0
ERLPGSSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPT
 ||.    .|||. |||   .|| | . .. . . ||||. ..|.... ...|||||||  ||||||.... ..   |||.|.| |...||||.||||  
grlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkk.kkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdad

frMQEKYGDIVVTFDSALGRDGYQITSLYISHSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRDdgkTGPVVVHCSAGIGRTGCFVATSIG
   ...||.. ||  .    . .   .| . .... ... .| |.||||||||.| ..||.|.. |. |.. |   |||..||||||.|||| |.|    
..kpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad...tgpiivhCsaGvGrtgtFialdal

IKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALY
|.....|...|.. .|. .|..|  .|.| .||||.|..| 
idaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_PTPN6_pd Subfamily PTPN6 81-318 4.9e-72 237.5 In-house 55-297 (306) alignment 
Range on Protein: 81-318
Range on HMM: 55-297/306.0
SYRNRYPSILPNSRTRVSLPqIPDDPLSSYINANVLKG-YGEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTfrMQE
  .||| .|||   |||.|   |. | | |||||..|.   .. ...||||| |. ||.|||||.|  .. .|||.||  ||.. || ||||| .  ..|
keknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdee..eke

KYGDIVVTFDSALGRDGYQITSLYISH---SQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRDD-GKTGPVVVHCSAGIGRTGCFVATSIGI
.||.| ||  |    . |.. .| .|.   ... |....| ...||||||| .| ..|.....|.  |..    ..||.|||||||||||| |. . | .
eyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDill

KQIQKE---NKVDILKIVCGMRMERGGMVETDSQYEFVYRALYHHW
|.|.|.    ..|| |.|  .|  | |.| |..|| |||.|. .. 
kliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi
subfamily_PTPN12_pd Subfamily PTPN12 80-316 2e-71 235.3 In-house 40-275 (290) alignment 
Range on Protein: 80-316
Range on HMM: 40-275/290.0
SSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEInAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTfRMQE
   .|||  |||   .|| | .| ... |.|||||..||  ... ..||.||||. |..|||||||...  |.||. .. | . .|||||||. .  .. 
nvkknrykDilPydksrvelskieeeegsdYinanfikgvegkl.eyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeeg.eeel

KYGDIVVTFDSALG-RDGYQITSLYISHSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDrddGKTGPVVVHCSAGIGRTGCFVATSIGIKQI
..|.. || ..     |.. | .| . ...  |..| . |||||||||| |. .||.|...|.  |.    .  |.|||||||.||||  .|  .  ...
efgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqe...sedaPlvvhCsaGvGrtGtiiaidyvrell

QKENK---VDILKIVCGMRMERGGMVETDSQYEFVYRALYH
..|.    .|. ..|  .| .|  .| |  |||.||.|. .
kaekipeeldvfdlvlelrkqraalvqtkeqyelvykavae
subfamily_Ptp69D_pd Subfamily Ptp69D 81-316 6.2e-71 234.0 In-house 49-284 (307) alignment 
Range on Protein: 81-316
Range on HMM: 49-284/307.0
SYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEeINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPtfrMQEK
  .|||. | .  .||| |..|. .  |.||||. .||| |  . ||| |.|.  |..||||||.  .  .|||...|.| |. ||..|||.     . .
alknRyedikafDktRvkLkkingkedsdYinasfikgyke.kkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie...devq

YGDIVVTFDSALGRDGYQITSLYISHSQ-------SPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRDdgkTGPVVVHCSAGIGRTGCFVATSI
||||.|.. |    . | | .|..|. .         |..  | ||.|.|  ||...| ||.|...|.  .  .    .|.||||||| ||.| ||| ..
ygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln...rsPivvhCsaGvgrsgifvalds

GIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYH
 ..|...|.|||| ..|...| .|  .|.   ||.|.||||  
llqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralld
0037934 (Phosphotyrosine protein) phosphatases II 77-317 6.5e-71 234.0 In-house 7-241 (243) alignment 
Range on Protein: 77-317
Range on HMM: 7-241/243.0
LPGSSYRNRYPSILPNSRTRVSLpqipDDplSSYINANVLKGYGeeiNaFIATQGPLSCTVND----FWRMIWYHHCPIIVMITKLKERNETKCERYWPd
|| .  .|||..|||. ..|| |    ..  |.|||||  ....   . .|||||||. ||.|    ||||.| ... .|||.|.|.|..  ||..||| 
lpenlsknrysdilpydhsrvkl....eg..sdyinanliyvtp...r.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.

PTFrmqeKYGDIVVTFDSALGRDGYQITSLYISH---SQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDR-----DDGKTGPVVVHCSAGIGR
 ..     |||..||. |    |.| .. |....   .. .|  .||.|..|||||||||| .||...|||.  ...      . . |||.||||||.||
gev....tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR

TGCFVATSIGIKQIqkenKVDILKIVCGMRMERGG-MVETDSQYEFVYRALYHH
||...|  . ....    .||....|. .|. |.| .|.| |||.|.|.||...
tGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_PTPN9_pd Subfamily PTPN9 63-315 3.8e-70 231.3 In-house 25-287 (297) alignment 
Range on Protein: 63-315
Range on HMM: 25-287/297.0
FWEIPMNHPPAEERLPGSSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERN
  . |..      .|.. . .|||  .|   .||| |.....|. | ||||| . || .. .|||||||||  ||.|||||.| ... .|||.|.. || 
irnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqk.kafiatqGplkktvsdfWrmvWeqevlvivmttrvverg

ETKCERYWPDPTfRMQEKYGDIVVTFDSALGRDGYQITSLYISHS--QSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQ--------DRDDG--K
  || .|||. .   ....||. |.  .   .. |....| |...  .  |.. |. ...|||.|||.|  .||.....|  .|        |.. |  .
rlkcgqyWplee.essaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghps

TGPVVVHCSAGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALY
  |.|||||||||||| |..  | .........||. . |  .|  |  .. |. |||| | |. 
gPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavl
subfamily_PTPRA_pd Subfamily PTPRA 53-318 5.5e-70 230.8 In-house 28-295 (330) alignment 
Range on Protein: 53-318
Range on HMM: 28-295/330.0
VDNTKQLYAEFWEIPMNHPPAEERLP---GSSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEeINAFIATQGPLSCTVNDFWRMIWYHHC
 |..|..  ||  .|  .  |   |        .||.. |||.  .|| |...   . | ||||  ..|| |  . |||.|||.. ||.||||||| .. 
addnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGyke.kdkfiaaqGPkeetvedfwrmiweqks

PIIVMITKLKERNETKCERYWPDPTFrmqEKYGDIVVTFDSALGRDGYQITSLYIS------HSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLA
  |||.|.||||.|.||..||||        ||.| |. .       | .  . .       . ...| .  . .|.||| |||  |. .|.|. .|.  
ativmltelkerkeekcaqywPdeGl...vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkkl

QDRddgKTGPVVVHCSAGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYHHW
...   ..||.|||||||.|||| |.. .  ..... |.|||. ..|  .|. |  || || ||||.|..| ...
nqq...sagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 56-315 4.3e-68 224.7 In-house 21-280 (305) alignment 
Range on Protein: 56-315
Range on HMM: 21-280/305.0
TKQLYAEFWEIPMNHPPAE-ERLPGSSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVM
.|.| |.. ...... . . ..   .  .||. .| .    |. | . .... | ||||. ..|| .. ...|..||||  ||.||||.|.  .   |||
dkgleaqykslyeeeesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrk.kkyivaqgPlkntvadfWrliveekvstivm

ITKLKERNETKCERYWPDPTfRMQEKYGDIVVTFDSALGRDGYQITSLYISH---SQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRDdgKT
.|||.| .. ||..|||. . . ....|...|.  |     .| .  | ||    ..  | . .|  | |||||||...  ||.|...|. .| .|  | 
ltklveggkdkCrqYWpesk.tekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkd..kg

GPVVVHCSAGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALY
 |..||||||.|||| |.| .| . ...||. ||. ...  .| .| .||.|  || |.. || 
vpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdald
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 79-314 4.9e-67 221.3 In-house 55-286 (298) alignment 
Range on Protein: 79-314
Range on HMM: 55-286/298.0
GSSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYgEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDptfRMQ
    .|||..|..   .|| | .. .|  | ||||  |..| .. |||||||.||  ||.|||||.. ..   |||.|.|.| ..||...||||   . .
enkkkNRyadiialdssRvvLekedadeesdYiNAsflhay.kgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPd...egk

EKYGDIVVTFDSALGRDGYQITSLYISHSQ--SPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLaQDRDDGkTGPVVVHCSAGIGRTGCFVATSIGIK
|.||.| |.  |      . .. | .|...  . |.. .  .| |||.|||   . .|.|...|.  . .. |   ||.|.||||.||.| |.| .  . 
etygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra.sqqqag.nkpvivqCsaGvgRsGtfiaidsvle

QIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRAL
...||..||....|  .|..| |.|.| .|| |.| | 
rvkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeav
subfamily_PTPRG_pd Subfamily PTPRG 78-315 9.6e-67 220.4 In-house 45-284 (563) alignment 
Range on Protein: 78-315
Range on HMM: 45-284/563.0
PGSSYRNRYPSILPNSRTRVSLPQIPDDPLS-SYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDptfR
| .  .||| .|..  |.||.| ..|.   .  ||||| ..||  . .|||||||||  |..||||||| ..  ||||||.|.||.  ||..|||     
penkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqks.kafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk...d

MQEKYGDIVVTFDSALGRDGYQITSLYISH------S--QSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRddgKTGPVVVHCSAGIGRTGCF
  |.|| . ||  .      |.. .| | .      .  .. .. ..| || |||||||...   |. |     |. .   ..||.|||||||.|||| .
esetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaanka...eaGPivvHcsaGvgrtGty

VATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALY
.. .  .||||.||.|......  .|..|  .|.|  || |.. || 
ivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdall
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 60-316 6.9e-66 217.2 In-house 21-274 (281) alignment 
Range on Protein: 60-316
Range on HMM: 21-274/281.0
YAEFWEIPMNHPPAEERLPGSSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLK
|... .| ....    . .    .|||  |     ||| . .  ..  . ||||| ..|| .| ...||||||.  ....||.|.| ..  .|||.|.  
yeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykge.keyiatqgPvPaslvafWqmvweqkvsaivmvtrei

ERNETKCERYWPDPTFrmQEKYGDIVVTFDSALGRDGYQITSLYI-SHSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRDDGktGPVVVHC
| .  || |||||..   . ||||..|.. ..  .  |    . .  .|  .|.. .  ||||||||||.....||.  .||. .....     |.|.||
eagklkChrYWPddns..elkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktk..aplvihC

SAGIGRTGCFVATSIGIKQIQ-KENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYH
|||.||||...|    .|... .....|.  .|  .| ||  || |  ||||||.|. .
saGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavld
subfamily_PTPRK_pd Subfamily PTPRK 82-314 1.7e-65 215.9 In-house 45-273 (314) alignment 
Range on Protein: 82-314
Range on HMM: 45-273/314.0
YRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYgEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTfrmqEKY
 .||.  ||.  |.|| | .| .|| | ||||... .| .  .|||.|||||  ||.||||... ..|  |||.|.|.|    || .|||. |    |.|
eknrsgdilaydrsrvflitidgdpssdyinaalidsy.krpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedt....evy

GDIVVTFDSALGRDGYQITSLYISH----SQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRddgKTGPVVVHCSAGIGRTGCFVATSIGIKQ
||| |.. ..     . .  . ...     .  | . .. ...||||.|| | . ||.|| .|.  |.    . |..||||||| ||||.|.| .| .  
gdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee...eaGrivvhCsaGaGrtGtfiaidivldm

IQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRAL
|..|. ||. ..|  .| ..  ||||  || |.| ..
ieregvvdvfnavktlrsrkvnmveteeqykfiydvi
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 81-315 2.3e-64 212.0 In-house 10-239 (250) alignment 
Range on Protein: 81-315
Range on HMM: 10-239/250.0
SYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETkCERYWP-DptfrMQE
  .|||  |..   .|| | .   |  | ||||  |.|| |. .|||||||||. |..|||||.. ..   |||.|.||| ..| ...||| .      |
keknryadiialdssrvvLekekgdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve....kae

KYGDIVVTFDSALGRDGYQITSLYISHSQSP--RRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRddGKTGPVVVHCSAGIGRTGCFVATSIGIKQ
||||. |.  |      |... | .|. .    | . .. ...||| |||.  .  |.|...|.  |..   ...||.|.||||.||.|.|.| .  ...
kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqq..agnaPvivqCsaGvgrsGafiaidavler

IQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALY
..||..||. |..  .| .| ..||. .|| |||... 
lkkekvvdvfkvikvlrkdrphavesleqyvfvyeiil
subfamily_PTPN13_pd Subfamily PTPN13 82-315 8.1e-63 207.2 In-house 39-266 (273) alignment 
Range on Protein: 82-315
Range on HMM: 39-266/273.0
YRNRYPSILPNSRTRVSLPQIPDdplssYINANVLKG-YGEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTFRMQEK
 .|||  .||  .||| | .        ||||. .|   |..   .||.||||  ||.|||.|.|  .. .|.|.|. ||... ||.||||. . .    
dknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkv

YGDIVVTFDSALGRDGYQITSLYISHSQS--PRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDrddgKTGPVVVHCSAGIGRTGCFVATSIGIKQI
.. . |.      .||... .| ...|.|   |.. |  ...||||||| |. .|||.| ||   |.    ..||.||||||||||.| ...  . .  |
snrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt....dagPivvhcsaGiGrsGtlitidvvlgli

QKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALY
......|. .||  .|  | |.| |. || |||.|. 
erdkefdvkeivrklreqrqgvvqtkdqyifvykail
subfamily_PTPN3_pd Subfamily PTPN3 74-315 1e-62 206.6 In-house 35-272 (280) alignment 
Range on Protein: 74-315
Range on HMM: 35-272/280.0
EERLPGSSYRNRYPSILPNSRTRVSLPQIPDDplssYINANVLKG--YG-EEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYW
. |.|    .|||  |||   |||.| . . |    ||||| ..    . . .| .|||||||. |..|||.|.| ... .|||.| | ||  .|| .||
aarkpenlsknryrdilpydatrvklkesetd....yinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyW

PDPTFRMqeKYGDIVVTFDSALGRDGYQITSLYISHSQ--SPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQdrdDGKTGPVVVHCSAGIGRTGCF
|... ..  .||.. |.  .   .  | .  |......    |.. .  |.|||||||||.. ..|..|..|. ..    ||. |||||||||||||| .
Petedel..eygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr...sgkeePvvvhCsaGigrtGvl

VATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALY
..  . .  |.....| .|.||  ||  |. .|.| |||.||  |. 
illetalalieaaepvypldivrtmrdqramlvqtasqykfvCeail
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 81-315 2.7e-61 202.2 In-house 50-276 (315) alignment 
Range on Protein: 81-315
Range on HMM: 50-276/315.0
SYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPtfrmQEK
  .|||  |..  ..|| || .  || | |.||| ..||  . . .||.|||.  .|.||||... ...  |||.|.| |... |.|.||||     .  
kqknryiniiaydksrvqlpllendphsdyvnanfidGynkk.rryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk....kvi

YGDIVVTFDSALGRDGYQITSLYISHSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQdrdDGKTGPVVVHCSAGIGRTGCFVATSIGIKQIQK
|| | ||  |    . | . .| .   .  | .. . ||.||| ||| .   |..|.  |.  .   . . |..|||||||.|||| |.. .  ..|.. 
yGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhh...tnsvgaivvhcsaGvGrtGtfitldavldqaea

ENKVDILKIVCGMRMERGGMVETDSQYEFVYRALY
|| .|. ... |.|  | .||..  ||.|.| || 
enaidvynfitgvrqnrikmvqvaeqyqfiydall
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 54-316 4.9e-60 198.5 In-house 31-289 (319) alignment 
Range on Protein: 54-316
Range on HMM: 31-289/319.0
DNTKQLYAEFWEIPMNHPPAEE----RLPGSSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHC
|. ..| .||  ..   ..  .     |.    .||.  ||.  ...| | ..     | ||||  ..||  . . .||.||||  |..||||||| ..|
ddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrk.dkyiaaqGPldntladfWrmiweync

PIIVMITklkernETKCERYWPDptfRMQEKYGDIVVTFDSALGRDGYQITSLYISH---SQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDE-VHLAQD
  ||..|      . || .|||    ....|..   |  ||    . | . .. .|.    .  |..  . .  |||.||||.| .|..||.   || . 
stivllt......kdkcsqywpl...kivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltsk

RDDGKtgPVVVHCSAGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYH
 .. .  ..|||||||.|||| ...  . ......|..||. ..| ..| .|  .|.   || |.| ||  
enhra..nivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 62-319 6e-60 197.7 In-house 24-280 (315) alignment 
Range on Protein: 62-319
Range on HMM: 24-280/315.0
EFWEIPM--NHPPAEERLPGSSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLK
|| ..|    ..    | .    .|||  |||  ..|| |  | |.| | ||||  .|.. .. .|.||.|||| ..|.|||||.. ..   |||.||..
efhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvddd.kayiasqgPlkasvddfwrmvlqekvttivmvtkkq

ERNETKCERYWPDPTFRMqEKYGDIVVTFDSALGRDGYQITSLYISHSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAqdrDDGKTGPVVVHCS
| .  || .||||       ..| | |.  |     .  .  | . .|.. |..  . .| |||.||.     ||.|. ||      .. |. ...||||
egdkikcrqywPdrkads.vefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad...ngkkefsllvhcs

AGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRAL--YHHWR
||.|||| ...    ..||.... ||....|  .| .|  .| |. .| |.| |.  . .||
aGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwr
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 83-315 6.2e-60 197.8 In-house 54-281 (297) alignment 
Range on Protein: 83-315
Range on HMM: 54-281/297.0
RNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEeinAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNEtKCERYWPDPTFRMqekYG
..||  |||  . || |  . ||| | |.||  .||. .    .|.|| |   ||.|||.|.. ..  .|||.....||.. || |||.| .      .|
ksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt...fG

DIVVTFDSALGRDGYQITSLYISHSQ--SPRRLYHYWYTAWPDHGVPD--SPRQLLQLVDEVHlaQDRDDGKTGPVVVHCSAGIGRTGCFVATSIGIKQI
|..|.  |   | |.   .| .....  . | .  | .. |||. |.   | ..||.|..||.  .| .. . ||..|||.||.|||| ...    . ..
dvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevr..kdfsqnaegPllvhclaGvGrtgvlltidsvvaea

QKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALY
..|..|||...|  .| ||  .| |. ||.||| |. 
krekevdifglvkklrqerpylvqtkeqykfvyvavl
subfamily_PTPN23_pd Subfamily PTPN23 81-319 1.2e-59 196.5 In-house 44-281 (288) alignment 
Range on Protein: 81-319
Range on HMM: 44-281/288.0
SYRNRYPSILPNSRTRVSLPQIPDDplssYINANVLKGYGEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTfRMQEK
| .||.  |||  ..|| | .  ||    |||| ..|.       |||||.||  |.||||.|..  . ..|||... .|....|..||||  .    .|
seknrsrdilPyDhnRvklrgskDD....YinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedk.getvk

YGDIVVTFDSALGRDGYQITSLYISHSQ--SPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDR--DDGKTgPVVVHCSAGIGRTGCFVATSIGIK
.||. ||  |    . .    | ... .    . . |  .|.||..|||.|| .|||..|||. | .      || |.|||||||.|||| |      ..
fgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrkskt.PlvvhCsaGvgRtgvfalvyaavr

QIQKENKV-DILKIVCGMRMERGGMVETDSQYEFVYRALYHHWR
...|.| . ||...|  .| .|  ||.. .|..|.| |  .. |
elekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaar
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 81-316 6.1e-59 194.8 In-house 26-253 (284) alignment 
Range on Protein: 81-316
Range on HMM: 26-253/284.0
SYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITklkernETKCERYWPDptfRMQEK
  .||.  ||.  ...| | ..     | ||||  ..||  . . .|||||||  |..||||||| ..|  ||..|      . || .|||    ....|
kdknrighilafdknvvklerliGeefsdyinasfitGyqrk.dkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywpl...kivik

YGDIVVTFDSALGRDGYQITSLYISH---SQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDE-VHLAQDRDDGKtgPVVVHCSAGIGRTGCFVATSIGIK
..   |  ||    . | . .. .|.    .  |..  . .  |||.||||.| .|..||.   || .  .. .  ..|||||||.|||| ...  . ..
eerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhra..nivvhcsagvgrtgvyivldvlld

QIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYH
....|..||. ..| ..| .|  .|.   || |.| ||  
rmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 83-319 1.7e-58 193.0 In-house 46-279 (515) alignment 
Range on Protein: 83-319
Range on HMM: 46-279/515.0
RNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPD-PTFRMqeKY
.|||  |||  ..|| |  | |.| | |.||  ....  . .|.||.|||. ..|.||||... ..   |.|.||||| .  || .|||| |.  .  |.
knryknilPydsvrvklevindnPhsdyfnasyipsfdnd.kayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsv..kf

GDIVVTFDSALGRDGYQITSLYISHSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRddgKTGPVVVHCSAGIGRTGCFVATSIGIKQIQKE
| | |   |     |  .  | . ...  | .  . .| |||.|||   . ||.|. ||   ...    | |...|||||.|||| ...    . .... 
GsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgq...ythpliihcsaGvGrtGvvisidsvvahaktt

NKVDILKIVCGMRMERGGMVETDSQYEFVYRALY--HHWR
. ||....|  .| .|  .| |. || |.| |.    .||
rmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwr
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 78-315 2.3e-57 189.1 In-house 44-280 (290) alignment 
Range on Protein: 78-315
Range on HMM: 44-280/290.0
PGSSYRNRYPSILPNSRTRVSLPQIPDD--PLSSYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPtf
. .. .||.  |...   |. | .|...     .||||  .||| |. ...||||||.| |. |||..|| ....||||.|. .| ...||  ||||   
ssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykek.kqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds..

RMQEkYGDIVVTFDSALGRDGYQITSLYISHSQS---PRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQdRDDGkTGPVVVHCSAGIGRTGCFVATS
  .. || . ..  .    ..| .. | . ...|   .. . .|  |.|...|    |   |... |.   | | .|  ...|||||...||.. |.|. 
dtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktq.rkrg.ntsivvHCSdtvgrsavfcaaa

IGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALY
..|.. ..|  .|.....  .|. . |.|.|  ||..... . 
ttinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivl
subfamily_PTPN14_pd Subfamily PTPN14 57-317 6.4e-54 178.0 In-house 23-295 (300) alignment 
Range on Protein: 57-317
Range on HMM: 23-295/300.0
KQLYAEFWEIPMNHPPAE---ERLPGSSYRNRYPSILPNSRTRVSLPQIPDDpLSSYINANVLK-GYGEEINAFIATQGPLSCTVNDFWRMIWYHHCPII
 ....|. .|| ..  |.    .||    .||.. .||   .|| |    ..  . ||||  .|   | .   .|..||||  ||.|||.|.| ..  .|
gkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqli

VMITKLKERNETKCERYWPDPTFRM-QEKYGDIVVTFDSALGRDGYQITSLYISH--SQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRDDG
||.|. .|   .|. .|.|. . .  . ..|   ||       | .  |.| . |  |.  | ..|  || |||||||. ... |. ..||.  . . . 
vmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktns

K------TGPVVVHCSAGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYHH
.        ||.||||||.||||  . . . |. .......|| |..  .|  |  .|.| .||.|||..| ..
eveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvliky
subfamily_PTPN1_pd Subfamily PTPN1 58-314 5.5e-52 171.3 In-house 10-267 (290) alignment 
Range on Protein: 58-314
Range on HMM: 10-267/290.0
QLYAEFWEIPMNHPPAEERLPGSSYRNRYPSILPNSRTRVSLPQIPDdplsSYINANVLKgYGEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITK
..| .  .   ..| .| .||    .|||  . |   .|. | .        ||||....   |    .| |||||. ||. ||.|.| ...  .||. |
eiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslve.leeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnk

LKERNETKCERYWP--DPTFRMQEKYGDIVVTFDSALGRDGYQITSLYISH--SQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRDDgKTGP
. |....|| .|||  . .  .. .   . |.. |   .. |..  | .    .|  | ..|. ||.||| |||.|| ..|... .|  .    . . ||
vvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslss.dvGp

VVVHCSAGIGRTGCFVATSIGIKQIQKENK---VDILKIVCGMRMERGGMVETDSQYEFVYRAL
.|.||||||||.| |.     . .|.|...   ||| | .. .|  | |.. |  | .| | |.
avihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylai
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 66-315 4.7e-51 168.8 In-house 32-285 (325) alignment 
Range on Protein: 66-315
Range on HMM: 32-285/325.0
IPMNHPPAEE--RLPGSSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYgEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKErNE
.| . . | .   .|    .||.. ...  ..|| |    ||| | ||||. |. .  . . |.|.| ||. |.||.||..   .|...|.. .|.. ..
lpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrdd.kkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldl.gk

TKCERYWPDPTfRMQEKYGDIVVTFDSALGRDGYQITSLYISHSQSP--RRLYHYWYTAWPDHGVPDSPRQL---LQLVDEVHLAQDRDDGKTGPVVVHC
 .|  |||.       ..| . | . ..     |    | .   .    | .  . . .|.| ||.  |  |   ||||..|.     .   ..|..|||
drcavywpkem.gksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhc

SAGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALY
|||.|||| |..    .... .| .|||.. |  .| .|  ||||  || ..| || 
saGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealv
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 82-314 9.2e-51 167.5 In-house 49-274 (287) alignment 
Range on Protein: 82-314
Range on HMM: 49-274/287.0
YRNRYPSILPNSRTRVSLPqipdDPLSSYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTFrmqEKY
 .||.  ||.    || |     .    ||||  ..|| |. .|||....|.. |. .||..|. .. ..|||....|| .| .| .|||. .      .
dknRltqilvpdnyrvllk....gehpdyinavfidgykek.kafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks...vvl

GDIVVTFDSALGRDGYQITSLYISHS---QSPRRLYHYWYTAWPDHG-VPDSPRQLLqLVDEVHLaQDRDDGKTgPVVVHCSAGIGRTGCFVATSIGIKQ
|.  ... .    .|| .  | . ..   ......  | .|.|...| |..    || ...|    ..|  |.| ..|||||...||.. |.|  ..|..
GeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtill.vieemyk.tqrkrgnt.sivvhCsdtvGrsamfcaaattink

IQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRAL
 ..|  .|.....  .|. . |.| | .||.|.. ..
ckteGviDvfqvlksqriqkpgsvqtveqykfindiv
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 80-315 1.4e-50 167.0 In-house 45-276 (439) alignment 
Range on Protein: 80-315
Range on HMM: 45-276/439.0
SSY---RNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNEtkcerYWPDptfR
 .|   .||| .. .   ||| | .||  | | ||||| .||| .. . .||||||   |..||||... ...  |||.|.| |        |||     
qeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyydd.klyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywps...d

MQEKYGDIVVTFDSALGRDGYQITSLYIS----HSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRDDgkTGPVVVHCSAGIGRTGCFVATS
 .  ||||.|  |  .    | |  . .     ...  | . .. |.||||. ||     .|...  .  |.|...  .||||||||||.||||  .|  
aevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkee..ygpvvvhcsagvGrtGtiiald

IGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALY
| ..|.. ||||||  ||  .| .|  ||..  || |.| |. 
ialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavl
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 81-316 3.7e-50 165.3 In-house 39-275 (287) alignment 
Range on Protein: 81-316
Range on HMM: 39-275/287.0
SYRNRYPSILPNSRTRVSLPQIPDDPlSSYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTFRMQEK
  .|||  .||   ||| | . ..   |.||||| . .| .. .||||.|||...||.||||... ..   ....|.  |    || .|||..   |.  
vkknryadvlPiddtrvllsaegelG.sdyinanyvasytdd.eafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvG

yGDIVVTFDSALGRDGYQITSLYISHSQSPR-RLY-HYWYTAWPDHGVPDSPRQLLQLVDEV--HLAQDRDDGKTGPVVVHCSAGIGRTGCFVATSIGIK
 |  || .|       | . .| . . ..   |.   . . .|||.... .   |...| .|  |.   ||  ..||.|||...||||.| ..|| . ..
.GysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvs

QIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYH
. ..  .||. ..|  .|. | ..| .  |. ..| ||  
rledlGrvdvaavvirlreyraalvqavvqlrllyealvt
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 84-314 1.8e-49 163.0 In-house 44-289 (301) alignment 
Range on Protein: 84-314
Range on HMM: 44-289/301.0
NRYPSILPNSRTRVSLPQIPD--DPLSSYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTfRMQEKY
||. .| .    |. | . |.      .||||. ..|| |. ..|||.|||.  |. ||||.|| ..   |||.|.|||. ..|||.|||. .   .|..
nrfknitvyddnriilkpkpnldlcqreyinasyidgysek.kkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnse.aeseef

GDIVVTFDSAL----------------G-RDGYQITSLYISHSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRDDGktGPVVVHCSAGIGR
| . ||. .                  |  .|| . .. .....|.. .  .  | ||..||   ||  || .|.|  .| . .|  ||||||||....|
gpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigg..gpvvVHCSdtVsr

TGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRAL
.| ... |||. | . |  ||. ...  .|  . |.| |  || ..| ..
sGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvi
0051429 (Phosphotyrosine protein) phosphatases II 106-319 4.1e-49 162.9 In-house 2-226 (272) alignment 
Range on Protein: 106-319
Range on HMM: 2-226/272.0
PLSSYINANVLKGYGEE--INAFIATQGPLSCTVNDFWRMiWYHHCPIIVMITKLKERNETKCERYWP---------DPTFRMQEKYGDIVVTFDSALGR
|||.||||. ..||| .   .......|||  |..||||. . ...  ||..... ||.  ||.||||          ..  ..  ||...||. |    
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

DGYQITSLYIS---HSQSPRRLYHYWYTAWPDHGVP-DSPRQLLQLVDEvhlaqdrddgkTGPVVVHCSAGIGRTGCFVATSIGIKQIQKENKVD-----
. | .. |...   . . .|...|..||.||||||| .. ..||.|. .            |||.||||||..|||..||  . . .. .|  ||     
ldyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld...........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYllt

---ILKIVCGMRMERGGMVETDSQYEFVYRALYHHWR
   ....|  .|  | |.|.|. ||.|.|.|| . .|
nlyleeaveelraqrpgavqteeqylflyeallellr
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 82-314 5.9e-49 161.5 In-house 35-262 (283) alignment 
Range on Protein: 82-314
Range on HMM: 35-262/283.0
YRNRYPSILPNSRTRVSLPQIPDdplsSYINANVLK--GYGEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDptfRMQE
  ||.  |.|  . || |   .     .||||  .      .. . .|..|.||  || |||.|.. ..   |||.|||.| .. || .|||    |  |
rknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPk...rGse

KYGDIVVTFDSALGRDGYQITSLYISHS---QSPRRLYHYWYTAWPDHGvPDSPRQLLQLVDEVHLAQdrDDGKTGPVVVHCSAGIGRTGCFVATSIGIK
.||.  ||     . . . |  | . ..   .|   | || .  | . | ....   |  .. |   |   . | ||.|||||.|||||. |.| |  .|
dyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleyg.eqaiinslvkfnkvislq..teskkgPivvhCstgiGrtavfiaasasvk

QIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRAL
... |  ||. ..|  || .| ..| |  || .|. . 
daltesvvdvfavvkimreqrmmavqtldqyklvhelv
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 83-314 5.9e-49 161.4 In-house 10-236 (239) alignment 
Range on Protein: 83-314
Range on HMM: 10-236/239.0
RNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTfrmqEKYG
.|||  |.   ..|| | .. .|| | ||||. |. |    .|.||||| .. .  |||||.|  .  .|||.| | |  . || .|||| |     || 
knryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst....skyc

DIVVTFDSALGRDGYQITSLYISHS-Q-SPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEvhLAQDRDDGkTGPVVVHCSAGIGRTGCFVATSIGIKQIQK
.. ||.  .     | | .. .|.  |   | .|.| .| |||.|||.    .| |  .  ...|   | . | |.|||||.||||.|.     ..| .|
nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrk..itkdslpg.arpwvihcsagvgrtgaflvidamlrqakk

ENKVDILKIVCGMRMERGGMVETDSQYEFVYRAL
.. |||.. |  .| .|  ||.|  || |.. |.
qktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 83-314 6.5e-49 161.2 In-house 11-237 (239) alignment 
Range on Protein: 83-314
Range on HMM: 11-237/239.0
RNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTfrmqEKYG
.|||  |.   ..|| | .. .|| | ||||. |. |    .|.||||| .. .  |||||.|  .  .|||.| | |  . || .|||| |     || 
knryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst....skyc

DIVVTFDSALGRDGYQITSLYISHS-Q-SPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEvhLAQDRDDGkTGPVVVHCSAGIGRTGCFVATSIGIKQIQK
.. ||.  .     | | .. .|.  |   | .|.| .| |||.|||.    .| |  .  ...|   | . | |.|||||.||||.|.     ..| .|
nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrk..itkdslpg.arpwvihcsagvgrtgaflvidamlrqakk

ENKVDILKIVCGMRMERGGMVETDSQYEFVYRAL
.. |||.. |  .| .|  ||.|  || |.. |.
qktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 82-314 9.3e-49 160.8 In-house 5-235 (237) alignment 
Range on Protein: 82-314
Range on HMM: 5-235/237.0
YRNRYPSILPNSRTRVSLPQIPDDplSSYINANVLKGYGEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTfrMQEKY
 .||| .|     .|| |     .  | ||||. |||.    . .||.||||  . .|||.|.|  .| .|||.| | |.|| || .|||.      . |
iknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstd..qpaay

GDIVVTFDSALGRDGYQITSLYISHS---QSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVhLAQDRDDGKTGPVVVHCSAGIGRTGCFVATSIGIKQI
| . |..        | . || .|.    .  | .. | .|.|||.|||.    ||..  .. . . .   ..|| ..|||||.|||| |.     ..| 
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkni.inrsphvsesgpwiihcsagvgrtgiflvidamlrqa

QKENKVDILKIVCGMRMERGGMVETDSQYEFVYRAL
.... ||| . |  .  .|  ...|  || |.....
kekkvvdiynyvysieedrpyiiqtkdqyvfihqti
0041856 (Phosphotyrosine protein) phosphatases II 82-318 4.3e-48 158.6 In-house 3-171 (182) alignment 
Range on Protein: 82-318
Range on HMM: 3-171/182.0
YRNRYPSILPNSRTRvslpqipddpLSSYINANVLKGYGEEINaFIATQGPLSCTVNDFWRMIWYHHCPIIVMITklkernetkCERYWPdptfrmqeky
 .|||. |||. ..|           ..|||||.. |.    . ||||||||  ||.||.||.. ... .||..|         .|.|||          
dknrysdilpydhsr..........dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywp..........

gdivvtfdsalgrdgyqitslyishSQSPRRLYHYWYTAWPDHGVPDsPRQLLQLVDEVHLaqdrddgKTGPVVVHCSAGIGRTGCFVATSIGIKQiqke
                         .  .|  ..|.|. |||||||| ...||....||.        . |||.||||||.||||..||  . .|.    
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle.......eggpvlVHCsaGvgRtgtlvaaylmkkl....

nKVDILKIVCGMRMERGGMVETDSQYEFVYRALYHHW
 .|.. ..|. .|. | |||.| .|| |...||....
.gvsleeavklvrsrRpgmvitpnqyfflqlallell
subfamily_PTPRN_pd Subfamily PTPRN 80-314 2.3e-47 156.1 In-house 56-288 (297) alignment 
Range on Protein: 80-314
Range on HMM: 56-288/297.0
SSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTFRMQE
   .||. ..||   .||.| .  ..  | |||| ..        |.|||||||. || |||.|.| . . .||..|.|.| . ..|.|||||    . .
nvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyh

KYGDIVVTfdSALGRDGYQITSLYISH--SQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQdrdDGKTGPVVVHCSAGIGRTGCFVATSIGIKQ
 |   .|.    .  | | . |.|.    ..  | .  . . .||..||| |.. ||..   |  .     |.. |.|||||.| ||||....  . ...
iyevhlvs..ehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksy...rGrscpivvhcsdGaGrtGvyilidlvlnr

IQKE-NKVDILKIVCGMRMERGGMVETDSQYEFVYRAL
..|  ...||   .  .| .| |.|.| .|.||.. |.
llkGvkeidiaatlehlrdqrpglvktkdqfefaltav
subfamily_CG7180_pd Subfamily CG7180 83-317 1.7e-46 153.2 In-house 45-289 (296) alignment 
Range on Protein: 83-317
Range on HMM: 45-289/296.0
RNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNEtKCERYWPDPTfrmQEKYG
.||.. ..|   .|| |...  .  | ||||    ..  . ...| |..|   ||..|||... ...  .|..||  . .. ..  |||  .   .|.||
knrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkk.keyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks...keqyg

DIVVTFDSALGRDGYQITSLYISHS-----------Q-SPRRLYHYWYTAWPD-HGVPDSPRQLLQLVDEVHLAQDRD--DGKTGPVVVHCSAGIGRTGC
.|.|   .       .|  . . .            .   | . .. .| |.  . || |   |..|.  |.| ...   | ..|||||..| | .|.| 
eifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGv

FVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYHH
..|  . . ...||..||. . |  .| .| ..||.  .| ..|  | ..
ylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
0046846 (Phosphotyrosine protein) phosphatases II 101-318 4e-46 152.3 In-house 5-173 (176) alignment 
Range on Protein: 101-318
Range on HMM: 5-173/176.0
QIPDDPLSSYINANVLKGYgeeinAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDptfRMQ--Ekygdivvtfdsalgrdgyq
.. .|. ..|||||.. |.     ..|||||||  |. ||..|.. ... ..|..|...| .  || .|||.    ..                      
llgldldldyinanlilgs.....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe...leklgi...................

itslyishsqsprrlyHYWYTAWPDHGVPDSpRQLLQLVDEVHLAQDRDdgktGPVVVHCSAGIGRTGCFVATSigikQIQKENKVDILKIVCGMRMERG
                .|... ||||||||. ..||.|..... |....    |||.|||||||||||..||       ...|. ........ .|. | 
................qylhlpwpDhgvpdl.elllellefirealkeg....gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRp

-GMVETDSQYEFVYRALYHHW
 |.|.|..||.|.|.......
lgavqtpeQyrflyefellll
0036282 (Phosphotyrosine protein) phosphatases II 108-311 2.9e-45 149.4 In-house 2-163 (174) alignment 
Range on Protein: 108-311
Range on HMM: 2-163/174.0
SSYINANVLKGYgEEINAFIATQGPLSctvndFWRMIWYHHCPIIVMITKLKERNETKCERYWPDptfrmqekygdivvtfdsalgrdgyqitslyiSHS
|.||||. |... .  . .||.||||.     ||.|.. ... ..|| ...||.. .|| .|||.                                 ..
sdyinaspldls.yitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lre

QSPRRLYHYWYTAWPDHGVPDSPRqLLQLVDEVHLAQDRddGKTGPVVVHCSAGIGRTGCFVATSIGIKQIQkENKVDILKIVCGMRMERGGMVETDSQY
   |  ..|.|. ||||||||..  ||..|..|. |. .  .. |||.||||||.||||..||  . ....  |. ||.|..|  .|. |.|||.|.|||
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealse..dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQy

EFVY
.|.|
rfly
0049772 (Phosphotyrosine protein) phosphatases II 67-317 3.7e-44 147.1 In-house 33-279 (314) alignment 
Range on Protein: 67-317
Range on HMM: 33-279/314.0
PMNHPPAEERLPGSSYRNRYPSILPNSrTRVSLPQIPDDPlSSYINANVLKGYgeeiNAFIATQGPLSCTVNDF----------WRMI--WYHHCPIIVM
. ..     .|.    .|||. |||   .|| ||  | .  |.||||. ..|.    ..||||||||..||.||          |||.  . ... .|||
lpeltilvadlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivm

---------------------ITKLKERNetkcerywPDPTFRMQEKYGdivvtfdsalgrdgyqitSLYISHSQSPRRLYHYWYTAWPDHGVPdSPRQL
                     ...| ...        . ||.. .| .                   . . ...  .|. ..|... .||...| .....
srdevladelsrLdaAlgKtpllildgng........neptaadlellk..................eelydpelferlgikylripvpDgsap.lledf

LQLVDEVHLAqdrddGKTGPVVVHCSAGIGRTGCFVATSIGIKQIqkenKVDILKIVCGMRMERG-----GMVETDSQYEFVYRALYHH
..... .. |      | |||.|||.||.||||.||.. . .|.     .|.. ...  .|. |      |..|.  ||||...||...
deflefieea.....dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealley
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 76-314 1.1e-43 144.2 In-house 29-291 (297) alignment 
Range on Protein: 76-314
Range on HMM: 29-291/297.0
RLPGSSYRNRYPSILPNSRTRVSLPQIPDDplSSYINANVLKGYGEEIN-AFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPT
. ..|  .|||  ||    ||| | . . .  . ||||. .    || .  .| .||||| ||.|||.... .   .|||..||.|    ||  |||.  
krnsslrknryrdilatddtrvkllrvite..rdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvv

fRMQEKYGDIVVTFDSALGRDgY---QITSLYISHSQSPRRLYHYWYTAWPDHGVP----DSPRQ-------------LLQLVD----EVHLAQ---DRD
   . | ||.|| | |    . .   ..| | . . .  | . |  . .|||||||    |  |              .| ||.     | |       .
.qerlkagdvvveflsstsde.fdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslrae

DGKTGPVVVHCSAGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRAL
  .  ...||||||.||.|  | . . .....|.   |.  |.  .| .|  .|.|  |.|..| | 
mprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 71-316 4.1e-43 142.3 In-house 36-234 (392) alignment 
Range on Protein: 71-316
Range on HMM: 36-234/392.0
PPAEERLPGSSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNetkceryw
| .  . .    .|||  |||  ..|| |  | | | | |.||  ....  | .|.||.||| .....|||||.. ..   |.|.||||| .        
pqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdne.kayiasqgpnaaslddfwrmvfqenvttiamvtklkegd........

pdptfrmqekygdivvtfdsalgrdgyqitslyisHSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLaqdrDDGK-TGPVVVHCSAGIGRTGCFV
                                   . .. |    . .| |||..||     ||... ||.     | |. | |...|||||.||||  .
...................................kgddartvaqfhftewPdkdvpkhtssllkfikevka....dfGqythpliihcsagvgrtgvvi

ATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYH
.    . . .|   ||....|  .| .|  ||.|. || |.| |.  
sidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle
0043147 (Phosphotyrosine protein) phosphatases II 105-311 4.9e-43 142.2 In-house 2-154 (172) alignment 
Range on Protein: 105-311
Range on HMM: 2-154/172.0
DPLSSYINANVLKGYGeEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLkernetkcerywpdptfrmqekygdivvtfdsalgrdgyqitslYI
|. | ||||. |..|   .. ||||||||..|..|||||.. ... .||..|.|                                            . 
degsdyinasyldlyy.ipdrfiatqgplrntladfwrmlkelgithivnltel............................................ly

SHSQSPRRLYHYWYTAWPDHGVPdSPRQLLQLVDEVHLAQDRDDGktGPVVVHCSAGIGRTGCFVATSIGIkqiqkeNKVDILKIVCGMRMERGGMVETD
  ..  |  ..|.|. ||||||| ....||.... .. .. ...|  |||.||||||.||||..||  . .       .......|. .|. |.|.|...
dpellerlgiqylylpwpDhgvp.llellleflefidellalspg..gpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnp

SQYEFVY
||| |.|
sqyrfly
0049260 (Phosphotyrosine protein) phosphatases II 124-311 8e-41 134.6 In-house 9-143 (152) alignment 
Range on Protein: 124-311
Range on HMM: 9-143/152.0
NAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWpdptfrmqekygdivvtfdsalgrdgyqitslyishsqsprrlyHYWYTAWPD
..|||||||.. |..|||||.. ... .|||.|.| |... |||.|.                                            .| .. |||
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................qylhlpwpD

HGVPDSPRQLLQLVDEVHLAqdrDDGKTGPVVVHCSAGIGRTGCFVATSIGIkqiqkeNKVDILKIVCGMRMERGGMVETDSQYEFVY
|||||..  ||.|.. .. .      | |||.||||||.||||..||  . .      ..|.....|  .|. | |.|.. .|..|.|
hgvpdlsqlllflllfiekl...aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 83-314 8.4e-40 131.2 In-house 59-279 (290) alignment 
Range on Protein: 83-314
Range on HMM: 59-279/290.0
RNRYPSILPNSRTRVSLPqipDDPLSSYINANVLKGYGeeiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTFRMQeKYG
.|||  .  | .||| |    |     |. || .||       || |||.|  || |.|||.  ..   |||. .| |   .|||.|.|.   ..   .|
knrykdvvcndktrvilk...dGydGdyvhanyvkGlk...amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevl.tfG

DIVVTFDSALGRDGYQI-TSLYISHSQS--PRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAqdrddgkTGPVVVHCSAGIGRTGCFVATSIGIKQIQ
.| |.      .|   |   | . . .|    .|.|.   .|||. |. |   ||...  .  |       .||||||||||||||| |||  .|.. . 
eitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka.......sGpvvvhcsaGiGrtGtfvaievglqill

KENKVDILKIVCGMRMERGGMVETDSQYEFVYRAL
.  ..|.|..|  .|  | . |. | ||  . ..|
dGkeldlldlvralrnsrlnsvqvdiqylalveil
subfamily_ptpA1_pd Subfamily ptpA1 81-280 1.9e-38 127.3 In-house 48-258 (418) alignment 
Range on Protein: 81-280
Range on HMM: 48-258/418.0
SYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYgeEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPT----FR
. .|||  |||  .||| | .| |   | ||||| . |     . ||.|||||  |. |||||.|  .| ||||...  |    ||.||||.      | 
tsknrytnilpvnhtrvqlkkiqdkegsdyinanyidga..ypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfs

MQEKYGDIVVTFDS----ALGRDGYQIT--SLYISHSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDR---DDGKTGPVVVHCSAGIGRTGC
.  .  ... |.       .     .|    . ..     | . .| |  |||| .||  . . ||.  .   |..      .  |..||||||.|||| 
iygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgt

FVATSIGIKQIQK
|... | .|....
fctavimmkkldh
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 58-317 2.5e-37 123.5 In-house 17-276 (307) alignment 
Range on Protein: 58-317
Range on HMM: 17-276/307.0
QLYAEFWEIPMNHPP--AEERLPGSSYRNRYPSILPNSRTRVSLPQipDDPLSSYINANVLkGYGEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMI
.|  || ..    |   . | .   . .|||  .    ..|. .    |   | || || | |   . . ||..||||  |. .|| |.  ..   ..|.
alvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvkf..dglasdyihanyl.giaikpkkficaqgplentqysfwamaiqekvesviml

TKLKERNETKCERYWPDPTF---RMQEKYGDIVVTFD--SALG--RDGYQITSLYISHSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHlaqdrdd
 |. |  . |||.|||        . |.   | |.      |    |  ..|.| .  .|  | . |. .. |||.|||.     . |.. |.       
ckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavr.......

GKTGPVVVHCSAGIGRTGCFVATS-IGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYHH
..| |||||||||.||.|  || | .  | |. .|  |. |.|  .| .|   ..|. || ...| | ..
ydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley
subfamily_CG42327_pd Subfamily CG42327 57-242 3e-37 123.0 In-house 5-192 (319) alignment 
Range on Protein: 57-242
Range on HMM: 5-192/319.0
KQLYAEFWEIPMNHPPAEERLPGSSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMIT
.... || ..|     |.|  ..|  ..|.  ..|   ||| |..|.||. . |..|. ..|| .  | .||.| .|  .  ||||..|     .|| .|
edvaeefrdlPqliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqlt

KLKERNETKCERYWPD-PTFRMQEKYGDIVVTFDSALGRDGYQITSLYISH--SQSPRRLYHYWYtAWPDHGVPDSPRQLLQLVDEVHL
.| |    .| .|.|   |   .. |||| ||.     .| | |..| . .   .  | | ||||  |.. .|| ... |. .. ||. 
dlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrs
0044763 (Phosphotyrosine protein) phosphatases II 92-317 4.3e-36 119.6 In-house 2-170 (178) alignment 
Range on Protein: 92-317
Range on HMM: 2-170/178.0
NSRTRVSLPQIPDDPLSSYINANVLKGYgeeinAFIATQGPlsctvNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTFrmqekygdivvtfdsa
  ||||.|. ... . | ||||.   ..      ......|      |...... ...  ||..|. .|..  || .|||. .                 
ldrtrvllsnleglersdyinaseilpg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

lgrdgyqitslyishsqsprrlYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRDDgktGPVVVHCSAGIGRTGCFVATSIGIKQiqkenKVDILKIVC
                      ..| .. .|||||||.....|..|. .. |.|...   |||.||||||.||.|..||  . .|.     .... ... 
......................iqylhipipDhgvpdllehflefvefieealdekg...gpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaie

GMRMERGgMVETDSQYEFVYRALYHH
 .|. |  .|....|....|.   ..
lvrerRp.ivpnpgqlrqLyefelrl
PTPc_DSPc_SM00012 213-314 1.4e-35 117.0 In-house 2-103 (105) alignment 
Range on Protein: 213-314
Range on HMM: 2-103/105.0
LYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRDDGkTGPVVVHCSAGIGRTGCFVATSIGIKQIQKE-NKVDILKIVCGMRMERGGMVETDSQYEFVY
..||.||.|||||||...  .|.|...|.  .   .  ..|||||||||.||||.||| .| ..|..|| ..|||..||. .|..| |||.|. || |.|
vkhyhytgwpdhgvPeesdsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

RAL
|||
ral
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 83-317 8.7e-35 115.0 In-house 36-258 (267) alignment 
Range on Protein: 83-317
Range on HMM: 36-258/267.0
RNRYPSILPNSRTRVSLPQIPDDplssYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNetkCERYWPdPTFRMQEKYG
|||.   ||   ||| | .  ..    ||||  ..||  . ||||.||.||. |. ||. .|  ...|.||..||  . |     ..|| | .   .|| 
rnrlddnlpyddtrvilrtkeee....yinasyvegyktk.nafivtqdplkntitdfltvihdqkvpvivlltkvftdn...irlfwP.Pkmgqakkyq

DIVVTFDSALGRDGYQITSLYISH-SQSPRRLYHYWYTAWPDHGvpdSPRQLLQLVDEVhLAQDRDDGKTGPVVVHCSAGIGRTGCFVATSIGIKQIQKE
|..| .      . ||| .| .    .| . .  |.|  |         .  |. .  . ||... .    |.||.||.|.||.| |.     ......|
dltvehslekeendyqiitlelkfknesahnvtlyyykkwnint...nnkpylkplfgi.laknqlengnrPlvvacsdGvGrsGtflvidsqlerakte

NKVDILKIVCGMRMERGGMVETDSQYEFVYRALYHH
. .|| . .  .|  | |.|.|  .| .... | ..
gvsdifdflrkirsqriglvdtkeryiyihellaey
0051082 (Phosphotyrosine protein) phosphatases II 106-315 2e-34 113.7 In-house 1-150 (151) alignment 
Range on Protein: 106-315
Range on HMM: 1-150/151.0
PLSSYINANVLKGYgeeinaFIATQGPLSctvnDFWRMIWYHHCPIIVMITKLKERNetKCERYWPDPTfrmqekygdivvtfdsalgrdgyqitslyis
|||.|||.. . |.      .....|||.    ||..... ...  ||......||.  .| .|.|.                                 
plsdyinfsyvtgg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg...............................

hsqspRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLaqdrddGKTGPVVVHCSAGIGRTGCFVATSIGIKQiqkenkVDILKIVCGMRMERGGMVETDS
     ....|.... |||.|.|.|. ..|......         | |||.||||||.||||..||  . . .      |.. ...  .|. |.|.| .  
.....ievlhipildwpdpglplsfdavleflellld......kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnq

QYEFVYRALY
|. |...||.
qflfqlfall
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 76-315 4.8e-33 109.0 In-house 33-266 (281) alignment 
Range on Protein: 76-315
Range on HMM: 33-266/281.0
RLPGSSYRNRYPSILPNSRTRVSLPQ-IPDDPLSSYINANVLKGYGEeINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPT
  |    .|||  |     .|| |   .|.   . || || ..        .| ||||   |  |||||||      |||. .. | |  ||  |.|  .
nqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspfl.krgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprna

FRmQEKYGDIVVTFDSALGRDGYQITSLYISHSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHlaqdrddGKTGPVVVHCSAGIGRTGCFVATSIG
     ..  . |... .        | | .|.    | . |. .  |||  ||.|   .|... ...        .. | |.|||||.||.| ..|  | 
hc.clqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkir.......arstppvihcsagvgrsgtlmaveia

IKQIQKENK-VDILKIVCGMRM-ERGGMVETDSQYEFVYRALY
.. |.      || .||  .|.  |   |.|  || .... | 
lqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvll
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 83-309 6.1e-33 108.8 In-house 53-272 (301) alignment 
Range on Protein: 83-309
Range on HMM: 53-272/301.0
RNRYPSILPNSRTRVslpQIPDDPLSSYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTF-RMQ-EK
..|||..  .  | |   .. .|     | || ..  |.  . ||||||||. | .||| |. ...   |||...  |..|.||| | |  .  ... ..
khryptvPckPstav...evivdGkrvPihanwiptsGhp.hrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigr

YGDIVVTFDSALGRDGYQiTSLYISHS---QSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDrddgktgPVVVHCSAGIGRTGCFVATSIGIKQ
.   ... .. |  . ..  .| .  |    ..| . || |. |.|.||| |  .| .|.. |  ...       |.||||||||||. .|..| .  ..
fkikiknkelilnkkisk.rtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksek.......PivvhcsaGiGrsvafigteylare

IQKENKVDILKIVCGMRMERGGMVETDSQYEF
.. ...... . .  .| .|   | | ||  .
veadptieltealkhlrehrwngvqtnsqlyw
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 83-316 9.5e-33 108.1 In-house 58-287 (305) alignment 
Range on Protein: 83-316
Range on HMM: 58-287/305.0
RNRYPSILPNSRTRVSLPQIPddpLSSYINANVLKGYGEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTFRMQEKYG
.|||  .  . .. | | . .    | || || .       . ||..||||  |...|| |.  ..   |||. |  |    || .|||      .|  .
knryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelks

DIVVTFDS---ALGRDG-YQITSLYISHSQ-SPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHlaqdrddGKTGPVVVHCSAGIGRTGCFVATSIGIKQ
 |||   |    . ||   ||| | ...|      . |  .| ||| |||      |.|.  .        |   |.||||||||||||  ||    ...
givvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsair.......gskvpivvhcsagigrtgtivaieyilek

IQKENKV-DILKIVCGMRMERGGMVETDSQYEFVYRALYH
| .....  . ..|  .| .|   ...| || |..| .  
iaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 82-312 1.1e-30 101.3 In-house 54-284 (310) alignment 
Range on Protein: 82-312
Range on HMM: 54-284/310.0
YRNRYPSILPNSRTRVSLpQIPDDPLSSYINANVLKGYGeEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPdpTFRMQEKY
..|||  ..    .|| | .|       || || .|      ..|| .||||  |. ||||||.   .  |... |  |    ||  |||  .. . | |
hknrysdvvcldtsrvkl.kidksryedyihanyvktny.lrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywp..slgvtety

GDIVVTFDSAlGRDGYQITSLYISH-------SQSPRR-----LYHYWYTAWPDHGVPDSPrqlLQLVDEVHLAQDRDdgktGPVVVHCSAGIGRTGCFV
| | ||  |    . ..|  | ..         . |       .    .  ||| ||||      . | .  ||| |     ||.|||||||..|... |
gcirvtnlse.sseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdek...chtvpqrllaqvrh....gpcvvhcsagkdrlyvvv

ATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYR
|  . |..... .|||. ...  .. .|   ..|. || .. |
alklkidkldrglkvdaeevktellksraiciqtelqyliidr
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 83-318 1.2e-30 101.3 In-house 51-287 (305) alignment 
Range on Protein: 83-318
Range on HMM: 51-287/305.0
RNRYPSILPNSRTRVSLpqIPDDPlSSYINANVLKGYgEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWP---DPTFRMQE
.|||  .    . || |   .  |   || || .     . . || || ||  |  ||| | . ..   | |. .|.|.   ||  |..   .... ..|
knrykdvgcldnnrvkl..egpwp.heyihanyvstp.tnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefee

KYGDIVVTFDSALGRDG-------YQITSLYISH-SQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLaqdrddgKTGPVVVHCSAGIGRTGCFVAT
|   |.| |.|.   .         . | | |    .. |.  || .  ||| ||| .   .|.|. .            ||.||||||||||||  |  
kgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarp.......skgpivvhcsagigrtgsvvml

SIGIKQIQKENKVD-ILKIVCGMRMERGGMVETDSQYEFVYRALYHHW
   ..|.   ....   ||.  .| .|   ..|| || ||.. .  ..
eyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 80-316 2.5e-30 100.5 In-house 43-269 (288) alignment 
Range on Protein: 80-316
Range on HMM: 43-269/288.0
SSYRNRYPSILPNSRTRVSLPqipDDPlSSYINANVLKgYGEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTFRMQe
.. |.||  .     ||| |    |||   ||.|||.   ..  . .| .| ||  |.. .|.|.       |||...| |.   | . |.|    .   
nptrdryenlprcditrvkls...ddp.dfyiaanvvs.sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGeka.

KYGD-IVVTFDSALGRD-GYQITSLYISHSQSPRR-LYHYWYTAWPDHGVPDSPRQLLQLVDEVhlaqdrdDGKTGPVVVHCSAGIGRTGCFVATSIGIK
..|    |. ..  . |   ... | ||.    .  . .  .  |.|.|||..    |.|.. .          . |.|||.|||.|||| .. . | ..
rigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.......kslqkPivvhssaGvGrtgtlililiale

QIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYH
... .. . | ...  .| ||   ..|  || .|.| ...
slrlddflgirsllaklreerfkaiqtemqylyvhrcvle
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 125-312 2.5e-29 96.8 In-house 5-197 (198) alignment 
Range on Protein: 125-312
Range on HMM: 5-197/198.0
AFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDpTFRMQEKYGDIVVTFDSALGRDGYQITSLYISH----SQSPRRLYHYWYTA
 .|||| ||  |. |||.|.|      |||.   .  .|.    |||  |     ||| . ||  .   .  | ||.| ..       | | . || .|.
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpt.tesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPDSPRQLLQLVDEVHLAQDRDDGKTGPVVVHCSAGIGRTGCFVATSIGIKQI--QKENKVDILKIVCGMRMERGGMVETDSQYEFVYR
| ..  |.    .  .|    ...  .. |  ||.|||| | | || |||  ||..     |   ||....   .|  | |.. .  .|.|.|.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 125-312 2.8e-29 96.7 In-house 6-198 (199) alignment 
Range on Protein: 125-312
Range on HMM: 6-198/199.0
AFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDpTFRMQEKYGDIVVTFDSALGRDGYQITSLYISH----SQSPRRLYHYWYTA
 .|||| ||  |. |||.|.|      |||.   .  .|.    |||  |     ||| . ||  .   .  | ||.| ..       | | . || .|.
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpt.tesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPDSPRQLLQLVDEVHLAQDRDDGKTGPVVVHCSAGIGRTGCFVATSIGIKQI--QKENKVDILKIVCGMRMERGGMVETDSQYEFVYR
| ..  |.    .  .|    ...  .. |  ||.|||| | | || |||  ||..     |   ||....   .|  | |.. .  .|.|.|.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_egg_pd Subfamily egg 85-319 4.5e-28 92.8 In-house 45-271 (307) alignment 
Range on Protein: 85-319
Range on HMM: 45-271/307.0
RYPSILPNSRTRVSLpQIPD-DPLSSYINANVLKGyGEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERneTKCERYWPDPTFRMQEK-YG
| . .  .  .|| | ...    |  .| || .|| .  .| || .| ||  ||.|||||..  ... |||.|  ||    .|| |||           |
rskrvhckdssrvkl.elrrGqylddfihanrvkG.kpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpG

DIVVT-FDSALGRD-GYQITSLYISHSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVhlaqdrddgkTGPVVVHCSAGIGRTGCFVATSIGIKQIQK
 . .. ..     |  ...| | .  ..   |   .|   .   .   || ..|... ..          . ||||..  |. .....||  | . .. .
slrienlkvdskadplfrvtklklvGgddeerflehwqgdvnnssdvysplrvlrklrnl..........skpvvvqdilGvskaatlvaieiallsllr

E--NKVDILKIVCGMRMERGGMVETDSQYEFVYRALYHHWR
    |  .|. |  .|..|   ||.  .| |||| .   .|
Gpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffr
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 84-315 2.1e-27 90.8 In-house 39-267 (285) alignment 
Range on Protein: 84-315
Range on HMM: 39-267/285.0
NRYPSILPNSRTRVSLPQIPDDplssYINANVLKGYGEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTFRMqEKYGD
|||  .     ||| | .   |    || |. ..  |.. ...|.|||||  |..|||.||.  .   ..|.  | |    ||  |.|.    .  |.| 
nryadvrcieetrvvlknhdrd....yihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgev.vkfgk

IVVTFDSA--LGRDGYQITSLYISH----SQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHlaqdRDDGKTGPVVVHCSAGIGRTGCFVATSIGIKQ
  .|.  .      |  . .| .      |  |  . |     |||.  |.  | ...|   |.    . . |  |..||||||.|||  ||       .
yeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvk....kvnpkekpicvhcsagvgrtatfvgidyatir

IQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALY
| .. ....| ||  ||  |   |..  |. |.|  | 
imenpniemldivremramrfqavqshmqflflyvvlm
0048076 (Phosphotyrosine protein) phosphatases II 202-316 3.1e-27 90.4 In-house 36-141 (145) alignment 
Range on Protein: 202-316
Range on HMM: 36-141/145.0
LYISHSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRDdgktGPVVVHCSAGIGRTGCFVATSIGIKqiqkeNKVDILKIVCGMRMERGGMV
|    .   |  ..|.|. ||||||||....||.... .. |....    |||.||||||.||||..||  . ..     ..|.. ...  .|. | |.|
ltselellerlgiqylylpwpDhgvpdllellleflefieealkeg....gpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgav

ETDSQYEFVYRALYH
....|..|.|.....
pnpgqlrflyefele
0048179 (Phosphotyrosine protein) phosphatases II 205-312 4.1e-26 86.8 In-house 48-139 (144) alignment 
Range on Protein: 205-312
Range on HMM: 48-139/144.0
ShsqsprrLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDrddgKTGPVVVHCSAGIGRTGCFVATSIGIkqiqkENKVDILKIVCGMRMERGGMVETD
         ..|... ||||||||.. .||.... .. |..    . |||.||||||.||||..||  . .     ...... ...  .|. | |.|...
e.......giqylhlpwpDhgvpdllellleflefieeale....eggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnp

SQYEFVYR
.|..|...
gqlrfLle
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 84-315 4.7e-24 79.6 In-house 47-273 (312) alignment 
Range on Protein: 84-315
Range on HMM: 47-273/312.0
NRYPSILPNSRTRVSLPQipDDplSSYINANVLKGYGeEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTFRMQ----E
|||| |    | | .|    |.    || || .|      . |..|||||  |.  ||..     .  |.... . |    || .|  |    ..     
nrypniqcwdrgrftlag..de..nfyihanfvkict.kperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhr

KYGDIVVTFDsALGRDG----YQITSLYISHSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHlaqdrDDGKtgPVVVHCSAGIGRTGCFVATSIGI
 | . .   .   |.      ...  . .  .    .| || ...|||||.|||    |.|.  |.      | |  ||. |||||.|||| ..     |
vyteycteie.iggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavk.....kdkk..pviahcsagvgrtgtlaliesmi

KQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALY
  ...  | .. ..   .| .|   |..  || .. |.. 
aalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvl
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 132-309 7.7e-22 72.1 In-house 99-279 (302) alignment 
Range on Protein: 132-309
Range on HMM: 99-279/302.0
PLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTFR------MQEKYGDIVVTFDSALGRDGYQITSLYISHSQS----PRRLYHYWYTAW
|   |.. .| .|  ..  |.| .....| .| ||  |. |             |  ..   ..    . .... .. |  ..     .. .    ..||
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PDHGVPDSPRQLLQLVDEVhlaqdrDDGKTgPVVVHCSAGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEF
|||| |. . . |...         .  |.  |.||||||.|||| .||   ||.  .|..  |.|.||. .|  | | | ...|  .
pdhGapkeaytaldilkfc......esykk.nvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliy
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 82-174 9.1e-22 72.2 In-house 49-154 (350) alignment 
Range on Protein: 82-174
Range on HMM: 49-154/350.0
YRNRYPSILPNSRTRVSLPQIPDDP--------LSSYINANVLKGY--GEEINA---FIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCER
 .|||  |||  ..|| |.. .  .         . ||||| ||    . |||.   .||||.||  ||.||...|   . ..|...|.. | |  ||.|
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPDPT
||.. .
YWqegs
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 95-311 1.1e-21 72.2 In-house 33-252 (290) alignment 
Range on Protein: 95-311
Range on HMM: 33-252/290.0
TRVSLPQIPDDPLSSYINANVLKgYGEEInAFIATQGPLS-------CTVNDFWRMIWYHHCPIIVMITKLKERNET----KCERYWPDPTfRMQEKYGD
||| | .      . || || .. . . . ..|.|| |.         |...|| |.   .   .||. . .|...      |..| |.     . |...
trvvLkgygkrfnddyiHAnrvt.cpngl.rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesv.geelkfkg

IVVTFDSALGRDGYQITSLYISHSQ-SPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHlAqdrddgKTGPVVVHCSAGIGRTGCFVATSIGIKQIQ-KE
. |   |    |. ..  | . . .  .  . |...  | .  |..... ||.|.. |. |      .. ||.|||  || |  .. |  .|   |  ..
ltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk.a......sktpvivHcvdGiSrsAalaaiilgyQkiaets

NKVDILKIVCGMRMERGGMVETDSQYEFVY
..| . ...  .| .|  .. .. .. || 
gsvkledvlkalrkqralaitsalelafvd
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 199-315 1.9e-21 70.9 In-house 78-191 (440) alignment 
Range on Protein: 199-315
Range on HMM: 78-191/440.0
ITSLYISHSQSpRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRddGKTGPVVVHCSAGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERG
| . ||.  .| | | .| | .|||.|||     .|.....|  .|..     ||..|||||| ||||  .|    ... .. ...||. ..  || .| 
inasyingies.rtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqek..agngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrp

GMVETDSQYEFVYRALY
 ||.|  || ||. |. 
qmvqtpeqyafvheavl
subfamily_CG42327_pd Subfamily CG42327 250-317 1.6e-19 64.7 In-house 246-314 (319) alignment 
Range on Protein: 250-317
Range on HMM: 246-314/319.0
KTGPVVVHCSAGIGRTGCFVATSIGIKQIQKE-NKVDILKIVCGMRMERGGMVETDSQYEFVYRALYHH
. ||.||||| |.||||  .|. | |.....  . ||| ..|  .| .|.  | |  ||||.|. |. .
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 134-309 1.7e-19 64.9 In-house 38-212 (255) alignment 
Range on Protein: 134-309
Range on HMM: 38-212/255.0
SCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTfRMQEKYGDIVVTFDSALGR---DGYQITSlYISHSQSPRRLYHYWYTAWPDHGVPDSP
| ||. |...|       .||.. ..| .  ||..|.|      . |. |. ||   .         .||| .... .  . . || |. |...  |. .
sltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplek.deklkladvnvtttkssadvvlrtleits.tlgekkkthtvkhysykGWieknaPela

RQLLQLVDEVhlaQdrDDgKtgPVVVHCSAGIGRTGCFVATSIGIK----QIQKEN--KVDILKIVCGMRMERGGMVETDSQYEF
|..|...  |   .  |  |  .||||||.||||.  || . .  .    .... .  ..| |...  .| .| . ..|  |  |
reilnilkvv...r..ds.k..svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlaf
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 129-316 2.3e-17 57.4 In-house 95-283 (302) alignment 
Range on Protein: 129-316
Range on HMM: 95-283/302.0
TQGPLSCT---VNDFWRMIWYHHCPIIVMITKLKERNEtKCERYWPDPTfRMQEKYGDIVVTF---DSALGRD-GYQITSLYISHSQSPRRlYHYWYTAW
.| | . .   |..||||.. ...  .|.. . .| ..   . ..|  .    ..||.. |     ..| .    | |  |    |.|.     |  | |
aQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkks.gdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvla.nvyvltnW

PDHGVPDSPRQLLQLVDEVhlaQDRDDGKTGPVVVHCSAGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYH
... ||..  .| . . .|    ...   . ..|.    |.|| | |..  . ....||.... |  ||  .| .|  .|.. .|| ..|.||  
kqkkvpvkyaeliktaakv...fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialll
subfamily_hpo-7_pd Subfamily hpo-7 133-309 1.5e-15 51.8 In-house 43-218 (263) alignment 
Range on Protein: 133-309
Range on HMM: 43-218/263.0
LSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTfRMQEKYGDIVVTFDSALG---RDGYQITSlYISHSQSPRRLYHYWYTAWPDHGVPDS
|  |.. |...|       .||..  .| .  ||..|.|      . |. .. |.   .         ...| .... .  . . || |. |...  |  
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlek.dekqklanvnvcttkvqsdvllktlells.tlgeKkkthtvkhysykgWiekndpel

PRQLLQLVDEVhlaqdRDDgKtgPVVVHCSAGIGRTGCFVATSIGIK----QIQKEN--KVDILKIVCGMRMERGGMVETDSQYEF
.|. |.... .     |.  |  ..|||||.||||.  |. . .  .    .... .  ..| |...  .| .| . ..|  |  |
areilnilkva.....rns.k..slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLaf
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 84-317 3.5e-14 47.1 In-house 51-278 (303) alignment 
Range on Protein: 84-317
Range on HMM: 51-278/303.0
NRYPSILPNSRTRVSLPQipddplSSYINANVLKGYGEeiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDP-TFRMQEKYG
||.  ..    ..| | .      |||| |. |.   .  .  | || ||| |  |||.||   .   ....    | ..   .  .|    |   |.  
nrfvdvicldhskvklsd......ssyihasyleldss..kkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeers

DIVVTFDSALGRDGYQITSLYISHSQSPRRLYHYWYTAWPDHGVPDS--PRQLLQLVDeVHlAQDRDDGKTGPVVVHCSAGIGRTGCFVATSIGIKQIQK
  |  |      ||...  | .|  .    |. . | |||   .|    |. . |. . .  .  |   .. | |    .| ||.| |         ...
irvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwq.lq.svlrkysdstptvymslsgcgragtfalfetahlslhs

E-NKVDILKIVCGMRMERGGMVETDSQYEFVYRALYHH
| . .|..| .  .|  |   |.  ||. .||  |  |
eqasldlvkclenvrngrlhavqnlsqfsvvytllaeh
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 197-317 6.5e-14 46.4 In-house 202-343 (350) alignment 
Range on Protein: 197-317
Range on HMM: 202-343/350.0
YQITSLYISHSQsPRRLYHYWYTAWPDHGVPDSPRQLLQLVD-------EVHLAQDRDDGKTGPVVVHCSAGIGRTGCFVATSIG------IKQIQKE-N
...|.. .. |. |  .|.  .  |.| ..   |...|| ..       .    .  |. .. |..||||||.|||| .|.          .....|| .
nsltaitlaasd.PyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesr

KVD--------ILKIVCGMRMERGGMVETDSQYEFVYRALYHH
|.|        |  ||  .|  |  || .  |. |.| || ..
kldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfy
0038934 (Phosphotyrosine protein) phosphatases II 210-313 4.6e-13 44.7 In-house 76-172 (194) alignment 
Range on Protein: 210-313
Range on HMM: 76-172/194.0
PRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRDDGKtgPVVVHCSAGIGRTGCFVATSIgikqiQKENKVDILKIVCGMRMERGGMVETDSQYEF
... ..|    .||.|.. |  .||. .| |.   ..| |.   |.||| ||.||||..||  .      . .. .  . .  .|. |.|.... ...| 
ekagieylklpfpddgtvPsleillrfldlvdeflnedpgg..vvaVHCkaGlgRtGtlvaaYL.....iyrlgmsaeeAialfrekRpgaipnqdylea

VYRA
... 
llkr
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 255-315 6e-13 43.0 In-house 2-62 (69) alignment 
Range on Protein: 255-315
Range on HMM: 2-62/69.0
VVHCSAGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALY
|||||.| |||| |.|  . . .|. |  |||.  |  ||  |  ||  . .| |.. || 
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalv
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 83-175 9.6e-13 42.2 In-house 51-158 (349) alignment 
Range on Protein: 83-175
Range on HMM: 51-158/349.0
RNRYPSILPNSRTRVSLPQIPDDP--------------LSSYINANVLKGYGEEIN-AFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCE
.|||  |||   .|| |.. .  .              |  ||||| ||    ...  .|||| ||  ||.||...|     .... ... || .  ||.
knrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcd

RYWPDPTF
.|| . ..
iywqelsy
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 255-315 1e-12 42.2 In-house 1-61 (69) alignment 
Range on Protein: 255-315
Range on HMM: 1-61/69.0
VVHCSAGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALY
|||||.| |||| |.|  . . .|. |  |||.  |  ||  |  ||  . .| |.. || 
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalv
subfamily_eak_pd Subfamily eak 83-227 2e-12 41.2 In-house 55-195 (332) alignment 
Range on Protein: 83-227
Range on HMM: 55-195/332.0
RNrYPSILPNSRTRVSLPQIPDDPLsSYINANVLKgYGEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTfRMQEKYG
||    |.|. |  | |     ..|  |||| ... . |  . .| |  .    |  ||.|.   . | ||.. .  | .  | ..|.|| | | . |.|
rn.vvkivpydrylvrltssqlnrl.Gyinaslae.fsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdkt.reelkfG

DIVVTFDSALGRDGYQITSLYISHSQSPRRLYHYWYTAWPDHGVP
 . |.  . . |. ..   | .|      |..|| .  | .  .|
ildverkefvkrniletrllelskGnethrvlhykvfGwtettlp
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 117-174 1.3e-11 38.5 In-house 230-283 (440) alignment 
Range on Protein: 117-174
Range on HMM: 230-283/440.0
KGYGEeINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLkerNETKCERYWPDPT
.||    ||||||| ||  || ||||..  ..   |.|. .|   |.  |  |||  |
egysk.knafiatqmpldstvldfwrlvhdyristiimlnql...ndktcsiywpvnt
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 78-188 8.7e-11 35.9 In-house 94-195 (244) alignment 
Range on Protein: 78-188
Range on HMM: 94-195/244.0
PGSSYRNRYPSILPNSRTRVSLPQipDDPLSSYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNEtkcerYWPDPTfRM
| .|..||  . ||    || | .       .||||  .   |     .| || ||. |  |||.|.   |  ..|..  ..| .|     ||||    .
pnnswknregaglpfdfnrvplsk..gsmgntyinasfvgclgrt.aeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede.....ywpdse.pl

QEKYGDIVVTF
.    || ||.
ewyeeditvtl
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 206-315 2.2e-09 31.1 In-house 213-341 (349) alignment 
Range on Protein: 206-315
Range on HMM: 213-341/349.0
HSQSPRRLYHYWYTAWPDHGVPDSPRQLLQ-------LVDEVHLAQDRDDGKTGPVVVHCSAGIGRTGCFVATSIGIK---QI-QKENKVD--------I
 ...|  |.   .  |.| ..   |  .||       |.|. .  .  |. .. ...|||||| |||| .|   . .       .. ||..        |
avekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDli

LKIVCGMRMERGGMVETDSQYEFVYRALY
  ||  .|  |  ||.  .|. ..| || 
siivnelrkqrismvqnlaqfiaiyealL
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 81-236 3e-09 30.0 In-house 28-164 (169) alignment 
Range on Protein: 81-236
Range on HMM: 28-164/169.0
SYRNRYPSILPNSRTRVSLPQIPDDPLSSYINAnvlkgygeeinafiatqgplsctvndfwRMIWYHHCPIIVMITKLKERNETKC--ERYWPDPTFRMQ
  .||  . |  |.||| | .. .|  | ||||                            ||||     .||..    ..|.     | |   |.  . 
etknrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlgdtddknnfwpekedyqlhpavilg

EKYGDIV-VTFDSA----LGRDGYQITSLYI-SHSQSPR-RLYHYWYTAWPDHGVPDSPRQLLQL
| | | . |  |       | .|    |. | |....   .|  . |..||. |||.|| .. .|
ewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqspvhvghl
PTEN_1 212-271 4.9e-09 31.3 In-house 93-150 (196) alignment 
Range on Protein: 212-271
Range on HMM: 93-150/196.0
RLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRDDgkTGPVVVHCSAGIGRTGCFVAT
. . |.   ..|||.|.  . .  ...  . .. ...   . |.||| ||.||.|. || 
sgveylhfpieDhgapslselfdicksfiewllsdpn..gnvVlVHCkaGlgRsGtvvaa
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 81-236 7.5e-09 28.6 In-house 27-163 (169) alignment 
Range on Protein: 81-236
Range on HMM: 27-163/169.0
SYRNRYPSILPNSRTRVSLPQIPDDPLSSYINAnvlkgygeeinafiatqgplsctvndfwRMIWYHHCPIIVMITKLKERNETKC--ERYWPDPTFRMQ
  .||  . |  |.||| | .. .|  | ||||                            ||||     .||..    ..|.     | |   |.  . 
etknrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlGdtddknnfwpekedyqlhpavilG

EKYGDIV-VTFDSAL----GRDGYQITSLYIS-HSQS-PRRLYHYWYTAWPDHGVPDSPRQLLQL
| | | . |  |       | .|    || |  ....  ..|  . |..||. |||.|| .. .|
ewytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqspvhvghl
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 109-225 9e-09 29.7 In-house 14-125 (130) alignment 
Range on Protein: 109-225
Range on HMM: 14-125/130.0
SYINANVLkGYGEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNEtkcerYWPDPTfRMQEKYGDIVVTFDSALGRDGYQITSLYISHS-
 ||||. . |  .  . .. || ||. |  |||.|.   .  ..|..  ..| .|     ||||    ..    ||.||     . .  . . | |..  
tyinasfv.Gllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede.....ywpdse.Plewyeediivtltdrdefknikasnleiesdl

-QSPRRLYHYWYTAWPDHG
 .| . |  .  . ||  |
neshqaltmfqisnwpsdg
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 216-314 1.5e-08 28.6 In-house 232-334 (347) alignment 
Range on Protein: 216-314
Range on HMM: 232-334/347.0
YWYTAWPDHGVPDSPRQLLQLVDEVHLAQDR----DDGKTGPVVVHCSAGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVY
|  |.|| .  ||  ...| ||             . .|  |||| |  |. |.   | ||| |.|. . .  |  ..   || .| |.      | .  
yncttwpwkkypddekkvlalvrapvkesstslianleklapvvvmcdlgldrsatvvltsiiieqvldgktpdcddlfkkmrdqragvftmsifytyai

RAL
|| 
raa
subfamily_PTPDC1_pd Subfamily PTPDC1 213-310 1.6e-08 29.2 In-house 83-168 (182) alignment 
Range on Protein: 213-310
Range on HMM: 83-168/182.0
LYHYWYtAWPDHGVPdSPRQLLQLVDEVHLAQDRddGKtgpVVVHCSAGIGRTGCFVATSIGIKqiqkeNKVDILKIVCGMRMERGGMVETDSQYEFV
.|.| . .|.|.||. | ...|..|  |. | ..  ||   | ||| || ||||  .|. .  .     ....  | .  .| .|   ..| .| |.|
iyvynf.gwkDygva.sleriLdivkvvafalqe..gk...vavhChaGlGrtGvliacylvya.....krltaekaiklvrskrpksiqtreqvelv
subfamily_CDC14_pd Subfamily CDC14 250-318 3.4e-08 27.7 In-house 262-324 (328) alignment 
Range on Protein: 250-318
Range on HMM: 262-324/328.0
KTGPVVVHCSAGIGRTGCFVATSIgikqiQKENKVDILKIVCGMRMERGGMVETdSQYEFVYRALYHHW
 .| ..||| ||.||||...|. .      |. ..    ..  .|. | |.| .  | .|...   . |
aeGaiavhCkaGLGrtGtLiacyl.....mkhyrftaaeaiawlricrPGsvig.pqqkfleekqaalw
subfamily_PTEN_pd Subfamily PTEN 194-311 4.4e-08 28.3 In-house 59-173 (184) alignment 
Range on Protein: 194-311
Range on HMM: 59-173/184.0
RDGYQITSLYISHSQSPRRLYHY-WYTAWPDHGVPdSPRQLLQLVDEVHLAQDRDDGKTgpVVVHCSAGIGRTGCFVATSIgIKQIQKENKVDILKIVCG
.| |.|  |   .. . ... .    .   ||  | .   | ..|....   ..|. .   ||||| || ||||  ... . .|. . |.. ..|..   
kdhykiynlrserkydskkfdgrvavypfdDhnpp.plelleeivediekwleedkknv..vvvHCkaGkGRtGvlivayl.lkslllekaeealelfae

MRMERGGMVETDSQYEFVY
.|.. .  |   ||  .|.
aRtknkkgvtiPsqrRYve
subfamily_DSP23_pd Subfamily DSP23 227-312 1e-07 26.7 In-house 64-140 (148) alignment 
Range on Protein: 227-312
Range on HMM: 64-140/148.0
PDSPRQLLQLVDEVhlaqDRDDGKTGPVVVHCSAGIGRTGCFVATSIgikqiQKENKVDILKIVCGMRMERGGMVETDSQYEFVYR
| .. |. ..|  |    .  . |.  | |||  | |||| ..|  .      ||.|.   . .  .|  | | |||  | . |. 
ppaleqvvefvrvv....eeaeekneavsvhcllgrgrtgtmlacyl.....vkerklaaaeaiaevrrlrpgsvetveqeklvrd
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 103-157 1.2e-07 25.6 In-house 65-118 (347) alignment 
Range on Protein: 103-157
Range on HMM: 65-118/347.0
PDDPLSSYINANVLKgYGEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITK
. |.  .||||  .| . .  . .| || ||  || |||.|.   .   .| | .
raddvetyinashik.fdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtife
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 135-314 8.2e-07 21.9 In-house 129-305 (346) alignment 
Range on Protein: 135-314
Range on HMM: 129-305/346.0
CTVNDFWRMIWYHHCPII-VMITKLKERNETKCERYWPDPTFRMQEKYGDIVVTFDSALGRDGYQITSLYISHSQSPRRLYHYwYTAWPDHgvpDSPRQL
  |.||| ||.  .  .. .|.   | .| |       .  ..   |        | .     | |  |    |.|     |. .. |      . | . 
sfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicqvhh.hapwkhl...qqppkt

LQLVDEVHLAQDRDDGKTGPVVVHCSAGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRAL
| ..  .|      . ..  | |    | ||. .|. .   |.|..   . .|..|.  .. .| | ||. .||  .|  .
lpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaiv
0048567 (Phosphotyrosine protein) phosphatases II 214-270 8.7e-07 23.4 In-house 28-96 (157) alignment 
Range on Protein: 214-270
Range on HMM: 28-96/157.0
YH----------YWYTAWPDHGvPDSPRQLLQLVDEVHLAQDRDDGKTGPVVVHCSAGI---GRTGCFVA
|.          .... . |.| | .  .| ...  ..   .  . . ....|||.||    |||.....
ynalyFsiddglvyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLig
DSPc Dual specificity phosphatase, catalytic domain 248-270 7.7e-06 20.8 Pfam-A 70-92 (133) alignment 
Range on Protein: 248-270
Range on HMM: 70-92/133.0
DGKTGPVVVHCSAGIGRTGCFVA
. | . |.||| ||| |......
eqkgkkvlVHCqaGisRSatlii
DSPc Dual specificity phosphatase, catalytic domain 248-270 7.7e-06 20.8 In-house 70-92 (133) alignment 
Range on Protein: 248-270
Range on HMM: 70-92/133.0
DGKTGPVVVHCSAGIGRTGCFVA
. | . |.||| ||| |......
eqkgkkvlVHCqaGisRSatlii