Gene PTPN9 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN9
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP078_AA protein Get Run
NvecP078_AA_309-599 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN9_pd Subfamily PTPN9 310-604 1.6e-159 524.7 In-house 1-296 (297) alignment 
Range on Protein: 310-604
Range on HMM: 1-296/297.0
MRIMEFLAHVKGLGRRGIRRQYLELRNMPVEGTFLRTKLRANLRKNRYTDVLCVEETRVPLSPVDEDDCSDYIHANFTDGYRQHKAFIATQGPLPNTTSD
..|.|..|.||  |.||....|.|.||.|||||||..||||||.|||||||||..|||| |. ||||..||||.|||.|||.|.||||||||||..|.||
keieelvayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsd

FWRMVWEQGAMVIVMITRCMERGRVKCRRYWP-EDGDCDDHVDLRVQHVETQEYEDHVERIFTIDHVQTGQSRTIIHFQMTSWPDFGVPSSAESCLHILG
|||||||| ..||||.||..||||.||..||| |........||.|..||..|.||...|...|..|.|..||...|||..||||.||||||.|.|..| 
fWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvle

LVRQAQASAVLAMGPSWKGHPSGPPIVVHCSAGIGRTGTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEFALSLPSI
 ||..||.|| ..|..||||||||||||||||||||||||.||||..|||...|....|.|||.||||||..||||||||||.|||||.||.|...
kvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyalelkal
subfamily_PTPRD_pd Subfamily PTPRD 314-598 3.9e-99 327.8 In-house 12-281 (564) alignment 
Range on Protein: 314-598
Range on HMM: 12-281/564.0
EFLAHVKGLGRRGIRRQYLELRNMpVEGTFLRTKLRANLRKNRYTDVLCVEETRVPLSPVDEDDCSDYIHANFTDGYRQHKAFIATQGPLPNTTSDFWRM
|..|..|  .   . ..| ....   . |.   .  || .|||| ...  ...|| ||.|. |. |||| |.| ||||..||.|||||||..|..|||||
ehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRm

VWEQGAMVIVMITRCMERGRVKCRRYWPEDGdCDDHVDLRVQHVETQEYEDHVERIFTIDHVQTGQSRTIIHFQMTSWPDFGVPSSAESCLHILGLVRQA
||||   .|||.|.. |.|.||| .||||.|    . .| |. .|..|..| . | |.. . .. .||.. .|. ||||| ||| ||.| |...  ||..
vweqnsstiVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvral

QAsavlamgpswkghPSGPPIVVHCSAGIGRTGTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEFA
.              |   |||||||||.||||||...|. . |...|.. .| ..|| ||.|| .|.||.||| |.| |.||. 
ne.............pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheaileal
0051299 (Phosphotyrosine protein) phosphatases II 310-598 3e-98 324.1 In-house 8-286 (288) alignment 
Range on Protein: 310-598
Range on HMM: 8-286/288.0
MRIMEFLAHVKGLGRRGIRRQYLELRNMPVEGTFLRTKLRANLRKNRYTDVLCVEETRVPLSPVDEDDCSDYIHANFTDGYRQHKAFIATQGPLPNTTSD
  ..... ...  |  |..... ||... . .|.  ..| .|| ||||.|.|. . .|| ||..|... ||||.|.. |||.. ..|||||||||||..|
eellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntved

FWRMVWEQGAMVIVMITRCMERGRVKCRRYWPEdGDCDDHVDLRVQHVETQEYEDHVERIFTIDHV----QTGQSRTIIHFQMTSWPDFGVPSSAESCLH
||||||||.  ||||.|...|.||.|| .|||. |..  . |..|  .......| . | ... ..    ..|.|||..||..|.|||.|||.|.|..|.
FWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellld

ILGLVRQAQAsavlamgpswkghPSGPPIVVHCSAGIGRTGTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEFA
.| |||.|.|             ..|.|.|||||||.||||||..||. ...|..||.... ..||.||.|| .|.||||||.|.. |.||..
flrlvrkala.............sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0050432 (Phosphotyrosine protein) phosphatases II 315-600 1e-97 322.4 In-house 32-301 (308) alignment 
Range on Protein: 315-600
Range on HMM: 32-301/308.0
FLAHVKGLGRRGIRRQYLELRNMPVEGTFLRTKLRANLRKNRYTDVLCVEETRVPLspvdeDDCSDYIHANFTDGY--RQHKAFIATQGPLPNTTSDFWR
  .. | |.. ...... ||..... ...  ..| .|  ||||.|.|. . .|| |     |. ||||.|.. |||  .. ..|||||||||||. ||||
lkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwr

MVWEQGAMVIVMITRCMERGRVKCRRYWPED--GDCDDHVDLRVQHVETQEYEDHVERIFTIDHVQTGQSRTIIHFQMTSWPDFGVPSSAESCLHILGLV
|||||.  ||||.|...|.||.|| .|||..  |..  . ...| ........|.. | ... ....|.|||. ||..|.|||.|||.|.|..|..| ||
mvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelv

RQAQasavlamgpswkghpSGPPIVVHCSAGIGRTGTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEFALS
|. .               .|.|||||||||.||||||..||. ...|..|| . . ..||.||.||..|.||||||.|.. |.||....
rksl...............pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
0046845 (Phosphotyrosine protein) phosphatases II 326-600 2.1e-94 311.3 In-house 1-276 (284) alignment 
Range on Protein: 326-600
Range on HMM: 1-276/284.0
GIRRQYLELRNMPVEG--TFLRTKLRANLRKNRYTDVLCVEETRVPLSPVDED-DCSDYIHANFTDGY-----RQHKAFIATQGPLPNTTSDFWRMVWEQ
|..... ||... |    ..  ..| .|| ||||.|.|. . .|| |...|.| . ||||.|.. |||     ...|.|||||||||||. |||||||||
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

GAMVIVMITRCMERGRVKCRRYWPEDGDCDDHVDLRVQHVETQEYEDHVERIFTIDHVQ-TGQSRTIIHFQMTSWPDFGVPSSAESCLHILGLVRQAQAS
.. ||||.|...|.||.|| .|||..|..  . |..|  .......|.. | ... ... ||.|||..||..|||||.|||.|.|. |..| |||... .
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

avlamgpswkgHPSGPPIVVHCSAGIGRTGTFCTLDINVSRLQHEG---VCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEFALS
           .|.|.|||||||||.||||||..||.  ..|..||   .. . ..||.||.|| .|.||.|||.|.. |.||....
...........lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
0040438 (Phosphotyrosine protein) phosphatases II 310-599 1.3e-93 309.0 In-house 3-277 (317) alignment 
Range on Protein: 310-599
Range on HMM: 3-277/317.0
MRIMEFLAHVKGLGRRGIRRQYLELRNMPVEgTFLRTKLRANLRKNRYTDVLCVEETRVPLSPVDEDDCSDYIHANFTDGYRQHKAFIATQGPLPNTTSD
. ....|  .. .. ....... .|...... |.  ..| .|  ||||.|.|. . .|| |||...|  ||||.|.. ||... ..|||||||||||. |
ldlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntved

FWRMVWEQGAMVIVMITRCMERGRVKCRRYWPEdGDCDDHVDLRVQHVETQEYEDHVERIFTIDHVQTGQSRTIIHFQMTSWPDFGVPSSAESCLHILGL
|||||||||  ||||.|...|.||.|| .|||. |.   . |..|......|... . | ... . ....|||. ||..|.|||.|||.| ...|..| .
FwrmvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldflea

VRQAQasavlamgpswkgHPSGPPIVVHCSAGIGRTGTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEFAL
||.|.              ..| |..||||||.||||||..... ...|..|| . . ..||.|| ||....||||||.|.. |.||. .
vreal.............edpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylk
0036941 (Phosphotyrosine protein) phosphatases II 322-599 2.4e-93 308.0 In-house 10-278 (297) alignment 
Range on Protein: 322-599
Range on HMM: 10-278/297.0
LGRRGIRRQYLELRNMPVEGTFLRTKLRANLRKNRYTDVLCVEETRVPLspvdEDDCSDYIHANFTDGYRQHKAFIATQGPLPNTTSDFWRMVWEQGAMV
|.. ...... || .. . |..  ..| .|| ||||.|.|. . ||| |    .|. ||||.|.. |||.. ..|||||||||||. |||||||||.  |
lflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtv

IVMITRCMERGRVKCRRYWPED-GDCDDHVDLRVQHVETQE--YEDHVERIFTIDHVQTGQSRTIIHFQMTSWPDFGVPSSAESCLHILGLVRQAQASAv
|||.|...|.||.|| .|||.. |.   . |..|. .....  ..| . | ... ....|.|||. ||..|.|||.|||.|..|.|... |||.... . 
Ivmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkll.

lamgpswkghPSGPPIVVHCSAGIGRTGTFCTLDINVSRLQ---HEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEFAL
          |||.|..||||||.||.|||...|. ...|.   .|| . |...||.||.||....||.|||.|.. |.||. .
..........psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellk
0047943 (Phosphotyrosine protein) phosphatases II 320-598 3.5e-91 300.7 In-house 7-272 (273) alignment 
Range on Protein: 320-598
Range on HMM: 7-272/273.0
KGLGRRGIRRQYLELRNMPVEGTFLRTKLRANLRKNRYTDVLCVEETRVPLspvdEDDCSDYIHANFTDGYRQHKAFIATQGPLPNTTSDFWRMVWEQGA
| ||........ .|.......|.  ..| .|. ||||.|.|... .|| |    .|. ||||.|.. |||.. ..|||||||||||. |||||||||..
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv

MVIVMITRCMERGRVKCRRYWPEDGD--CDDHVDLRVQHVETQEYEDHVERIFTIDHVQTGQSRTIIHFQMTSWPDFGVPSSAESCLHILGLVRQAQAsa
 ||||.|...|.||.|| .|||..|.     . ...| ........|.. | ... ...||.|||..||..|.|||.|||.| ||.|... |||.|..  
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkale..

vlamgpswkGHPSGPPIVVHCSAGIGRTGTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEFA
           ||..|.|||||||.||||||..||. ...|..||   . ..||.||.|| .|.||||||.|.. |.||..
.........alpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 312-615 8.5e-91 299.3 In-house 4-299 (318) alignment 
Range on Protein: 312-615
Range on HMM: 4-299/318.0
IMEFLAHVKGLGRRG---IRRQYLELRNMPVEGTFLRTKLRANLRKNRYTDVLCVEETRVPLSPVDEDDCSDYIHANFTDGYRQHKAFIATQGPLPNTTS
. ..  ||. | . |   . ..| .|   . . | |..   .| .||||...|  ..||| |......  |||| ||. ||||..||.||.|.|||.| .
vedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetie

DFWRMVWEQGAMVIVMITRCMERGRVKCRRYWPEDGDCdDHVDLRVQHVETQEYEDHVERIFTIDHVQTGQSRTIIHFQMTSWPDFGVPSSAescLHILG
|||||||||...||||.|...|||..|. ||||..|    . .|.|.  |. |..|.| | |.. . .. .||..  ...||||| |||.|.    ..| 
DfWrmvWeqnsavivmltqeeergkakvhryWPskgsr.sygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesg...aslld

LVRQAQasavlamgpSWKGHPSGPPIVVHCSAGIGRTGTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEFALSL-PSING-
||||..         ... ...  |||||||||.||||.|...|| . |...|.. .. .||| ||.||  |.|| .||||.. ..||.  |  . ..  
lvrqvs.........kaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdas

EDKQRIKEF
. ..||.|.
dlrsrirel
0043336 (Phosphotyrosine protein) phosphatases II 308-597 1.1e-88 292.6 In-house 3-276 (278) alignment 
Range on Protein: 308-597
Range on HMM: 3-276/278.0
PAMRIMEFLAHVKGLGRRGIRRQYLELRNMPVeGTFLRTKLRANLRKNRYTDVLCVEETRVPLSPVDEDDCSDYIHANFTDGYRQHKAFIATQGPLPNTT
. ......|....  ......... ||..... .|.  ..| .|  ||||.|.|. . .|| ||....|  ||||.|.. |||.. ..|||||||||.|.
svkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetv

SDFWRMVWEQGAMVIVMITRCMERGRVKCRRYWPedGDCDDHVDLRVQHVETQEYEDHVERIFTIDHVQTGQSRTIIHFQMTSWPDFGVPSSAESCLHIL
 ||||||||.|  .|||.|...|.||||| .|||  |.   . |..|  .......| . | ... . ..|.|||. |.. ..|||.|||.| .. |..|
edFwrmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldfl

GLVRQAQasavlamgpswkgHPSGPPIVVHCSAGIGRTGTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEF
  ||.|.             ..|. |..||||||.||||||..|.. ...|..||   . ..||.||.||....|||.||.|.. |.||.
kavreal.............edsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
0045450 (Phosphotyrosine protein) phosphatases II 323-597 2e-88 292.4 In-house 25-303 (307) alignment 
Range on Protein: 323-597
Range on HMM: 25-303/307.0
GRRGIRRQYLELRNMPV--EGTFLRTKLRANLRKNRYTDVLCVEETRVPLSPVDED-DCSDYIHANFT--------DGYRQHKAFIATQGPLPNTTSDFW
.. |..... .|... |   |..  ..| .|  ||||.|.|. . ||| ||..|.. . ||||.|..         |||.. ..|||||||||.|  |||
fltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFw

RMVWEQGAMVIVMITRCMERGRVKCRRYWPEDGDCDDHVDLRVQHVETQEYEDHVERIFTIDHV-QTGQSRTIIHFQMTSWPDFGVPSSAESCLHILGLV
||.||||  ||||.|...|.||.|| .|||..|.   . ...|  ........ . | ... .  .||.|||..||..|.|||.|||.| |..|... .|
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

RQAQASavlamgpswkgHPSGPPIVVHCSAGIGRTGTFCTLDINVSRLQHEGV---CEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEF
|.|...           .|.| |..||||||.||||||.....  ..|..||.   . . ..||.|| || ...|.||||.|.. |.||.
rkalee...........lpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
0039614 (Phosphotyrosine protein) phosphatases II 316-599 3.2e-87 288.0 In-house 23-290 (297) alignment 
Range on Protein: 316-599
Range on HMM: 23-290/297.0
LAHVKGLGRRGIRRQYLELRNMPVEgtFLRTKLRANLRKNRYTDVLCVEETRVPLSPVDE-DDCSDYIHANFTDGYRQ-HKAFIATQGPLPNTTSDFWRM
| . | ... ...... || .....  .  ..| .|  ||||.|.|. . .|| |.|.|. |  ||||.|.. |||..  ..|||||||||.|. |||||
lllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrm

VWEQGAMVIVMITRCMERGRvKCRRYWPEDGDcdDHVDLRVQHVETQEYEDHVERIFTIDHvqTGQSRTIIHFQMTSWPDFGVPSSAESCLHILGLVRQA
|||||  ||||.|...|.|| || .||||.|.   . |..|  ........ . | ... .  .|.|||. ||| |.|||.|||.|.|..|..| |||.|
vweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrea

QASAvlamgpswkghPSGPPIVVHCSAGIGRTGTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEFAL
.|..           |.| |..||||||.||||||..... ...|..||   . ..||.|| || ...|||.||.|.. |.||. .
lael...........pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk
DSPc_SM00195 327-597 5e-87 286.9 In-house 2-261 (263) alignment 
Range on Protein: 327-597
Range on HMM: 2-261/263.0
IRRQYLELRNMPVEGTFLRTKLRANLRKNRYTDVLCVEETRVPLSPVDEDDCSDYIHANFTDGYRQHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMIT
..... .|...  . ..  ..  .| .||||...|....||| |.. .... ||||.||. .|... |..||||||||.| .||||||||..  .|||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

RCMERGRVKCRRYWPED-GDCDDHVDLRVQHVETQEYE-DHVERIFTIDHVQTGQSRTIIHFQMTSWPDFGVPSSAESCLHILGLVRQAQASAvlamgps
...|.|. || |||||. |.  .. ...|. ||..... . . | ... . .. ..|.. ..|...||| |||.|..|.|..|  |.. . .        
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.......

wkghpsGPPIVVHCSAGIGRTGTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEF
       .|||||||||.||||||.|.|| .|.|..|   .| ..|| ||.||..|.|| ||| |.. |.||.
......sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 327-597 5e-87 286.9 In-house 2-261 (263) alignment 
Range on Protein: 327-597
Range on HMM: 2-261/263.0
IRRQYLELRNMPVEGTFLRTKLRANLRKNRYTDVLCVEETRVPLSPVDEDDCSDYIHANFTDGYRQHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMIT
..... .|...  . ..  ..  .| .||||...|....||| |.. .... ||||.||. .|... |..||||||||.| .||||||||..  .|||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

RCMERGRVKCRRYWPED-GDCDDHVDLRVQHVETQEYE-DHVERIFTIDHVQTGQSRTIIHFQMTSWPDFGVPSSAESCLHILGLVRQAQASAvlamgps
...|.|. || |||||. |.  .. ...|. ||..... . . | ... . .. ..|.. ..|...||| |||.|..|.|..|  |.. . .        
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.......

wkghpsGPPIVVHCSAGIGRTGTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEF
       .|||||||||.||||||.|.|| .|.|..|   .| ..|| ||.||..|.|| ||| |.. |.||.
......sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
subfamily_PTPRB_pd Subfamily PTPRB 325-597 3.2e-84 277.4 In-house 25-284 (293) alignment 
Range on Protein: 325-597
Range on HMM: 25-284/293.0
RGIRRQYLELRNMPVEGTFLRTKLRANLRKNRYTDVLCVEETRVPLSPVDEDDCSDYIHANFTDGYRQHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVM
 ..  .| ||...  . .   ..| .|  |||||..|  ...|| |....... |||| ||. .||.... |||||||||.|. ||||||||. . .|||
lrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivm

ITRCMERGRVKCRRYWPEDGDCDDHVDLRVQHVETQEYEDHVERIFTIDHvqTGQSRTIIHFQMTSWPDFGVPSSAESCLHILGLVRQAQASavlamgps
.|...|.|.||| .|||.| .   . |..|. |...|.||.| | ..| .  . ..|.. ... |||||.|||..... |...  ||.|. .        
ltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiek........

wkgHPSGPPIVVHCSAGIGRTGTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEF
   . |  |||||||||.|||||| .||  ......| . .|. .|  ||..|....|| .|| | | .||..
...taskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldl
0045098 (Phosphotyrosine protein) phosphatases II 328-598 1.9e-82 272.0 In-house 10-272 (278) alignment 
Range on Protein: 328-598
Range on HMM: 10-272/278.0
RRQYLELRNMPVEGTFLRTKLRANLRKNRYTDVLCVEETRVPlspvdeddcsDYIHANFTDGYrqHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITR
. .. .|. ..  ....   .. || ||||.|.|... .||           |||.|.. |||  .|.|||||||||.|..|||||.||.|  ||||.|.
llefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmlte

CMERGRVKCRRYWPEdGDCDDHVDLRVQHVETQEYEDHVERIFTIDHV----QTGQSRTIIHFQMTSWPDFGVPSSA--ESCLHILGLVRQAQASAVLAM
..|.||.|| .|||| |..  . |..|  .......| . | ... ..    ....||.. |.....|||.||||.    | |..|  .|.|.. ..  .
lvelgrekcaqywpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllasll

GPSWKGHPSGPPIVVHCSAGIGRTGTFCTLDINVSRLqhEGVCEIVNTVKYLRTQRAH-MIQTPEQYEFCHLAVLEFA
. |.  ..|| |..||||||.|||||.. ...  ..|  ||.. . ..||.||.|| . ..|..|||.|.. ..||. 
lsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 317-600 2.2e-82 271.7 In-house 15-285 (319) alignment 
Range on Protein: 317-600
Range on HMM: 15-285/319.0
AHVKGLGRRGIRRQYLELRnMPVEGTFLRTKLRANLRKNRYTDVLCVEETRVPLSPVDEDDCSDYIHANFTDGYRQHKAFIATQGPLPNTTSDFWRMVWE
 ...  | ....... .|. ..|. ||  ..   | .||||...| .. ||| ||..|. . |||| |.| |||.....|||||.|| ||..||||||||
kalastgetllekefkllk.eavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWe

QGAMVIVMITRCMERGRVKCRRYWPEDgDCDDHVDLRVQHVETQEYEDHVERIFTIDHVQTGQ-SRTIIHFQMTSWPDFGVPSSAESCLHILGLVRQaqa
......||.|.  |...||...||||  .  .   | |.  | .| || . | ..... ..   .|.. ||| |.||| .|| .| | |..|. .|.   
eessivvmltklveklkvklkkywpee.nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirk...

savlamgpSWKGHPSGpPIVVHCSAGIGRTGTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEFALS
        |.... || |||||||||.||||||..||. . |...||| .. .||. |||||  |.|.||||.|.. |.||.. .
........srektqsg.PivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleavea
0040439 (Phosphotyrosine protein) phosphatases II 344-597 2.5e-82 271.5 In-house 4-245 (249) alignment 
Range on Protein: 344-597
Range on HMM: 4-245/249.0
LRTKLRANLRKNRYTDVLCVEETRVPLSPVDEDDCSDYIHANFTDGYRQHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITRCMERGRVKCRRYWPEd
  ..| .|. ||||.|.|. . .|| ||....  .||||.|.. |||.. ..|||||||||.|..|||||.||.|  ||||.|...|.||.|| .|||. 
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.

GDCDDHVDLRVQHVETQEYEDHVERIFTIDHVQTGQSRTIIHFQMTSWPDFGVPSSAESCLHILGLVRQAQASAvlamgpswkghPSGPPIVVHCSAGIG
|.   . |..|. .......| . | ... ....|.|||. |.|.|.|||.|||.| |..| .. .||.|....           |.| |..||||||.|
ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel...........pkggpvlVHCsaGvg

RTGTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEF
|||||..... ...|..|.   . ..||.||.|| ...|.||||.|.. |.||.
RtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
subfamily_PTPRK_pd Subfamily PTPRK 308-599 7.3e-80 263.1 In-house 2-278 (314) alignment 
Range on Protein: 308-599
Range on HMM: 2-278/314.0
PAMRIMEFLAHVKGLGR---RGIRRQYLELRNMpvegtFLRTKLRANLRKNRYTDVLCVEETRVPLSPVDEDDCSDYIHANFTDGYRQHKAFIATQGPLP
||.|. . | ... | |    |....|  | .      .  .|   | .|||..|.|  . .|| | ..|.|  |||| |...|.|.. .|||.|||||.
pairvadllqsiallkraegygfkeeyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlq

NTTSDFWRMVWEQGAMVIVMITRCMERGRVKCRRYWPEDGDCddHVDLRVQHVETQEYEDHVERIFTIDHVQTGQ--SRTIIHFQMTSWPDFGVPSSAES
.|. ||||.|.....  |||.|  .| ||||| .|||||..   . |..|. |||.  .. | |||.. ... ||   |.. .|| ..|||..|| ||..
etvkdfWrlvydencasivmltelvevgrvkClkyWPedtev..ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatg

CLHILGLVRQAQASavlamgpswkghpSGPPIVVHCSAGIGRTGTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEFAL
 |...  | . |.              .  .|||||||| ||||||...|| .  ...||| .. |.|| ||...  |..| ||| |.. ..|| .|
llklvrrvkksqee.............eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileacl
0042113 (Phosphotyrosine protein) phosphatases II 348-597 1.5e-79 262.2 In-house 6-242 (245) alignment 
Range on Protein: 348-597
Range on HMM: 6-242/245.0
LRANLRKNRYTDVLCVEETRVPLSPVDEDDCSDYIHANFTDGYRQHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITRCMERGRVKCRRYWPEdGDCD
| .|  ||||.|.|. . ||| |||...|  ||||.|.. ||||. . |||||||||.|. |||||.||.|  .|||.|...|.||||| .|||. |.  
lpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.gesl

DHVDLRVQHVETQEYEDHVERIFTIDHVQTGQSRTIIHFQMTSWPDFGVPSSAESCLHILGLVRQAQASavlamgpswkghPSGPPIVVHCSAGIGRTGT
 . |..|. .... ..| . |.... ......||..||.. ..|||.|||.. |. | .| .||.|.|.            .|. |..||||||.|||||
tygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae............dsngpvlVHCsaGvgRtGt

FCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEF
|..... ...|..|.   . ..||.|| || ...|||.||.|.. |.||.
fiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
Y_phosphatase Protein-tyrosine phosphatase 351-596 5.5e-79 260.3 Pfam-A 1-235 (235) alignment 
Range on Protein: 351-596
Range on HMM: 1-235/235.0
NLRKNRYTDVLCVEETRVPLspVDEDDCSDYIHANFTDGYRQHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITRCMERGRVKCRRYWP-EDGDCDDH
|..||||.|.|. ..||| |   .... ||||.||. .||...|.||||||||..| .|||||||..   ||||.|...|.||.|| .||| |...   .
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

VDLRVQHV-ETQ-EYEDHVERIFTIDHVQTGQ-SRTIIHFQMTSWPDFGVPSSAESCLHILGLVRQAQasavlamgpswkgHPSGPPIVVHCSAGIGRTG
 |..|. . ... . .. . | ..... .. . .|.. ....|.||| |||.|..| |...  |.. .             ...  |.|||||||.||||
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.............eaksgpvvVhCsaGvgRtg

TFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLE
||..||| ...|..|.  .....|| ||.||..|.|. |||.|.. |.||
tfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 351-596 5.5e-79 260.3 In-house 1-235 (235) alignment 
Range on Protein: 351-596
Range on HMM: 1-235/235.0
NLRKNRYTDVLCVEETRVPLspVDEDDCSDYIHANFTDGYRQHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITRCMERGRVKCRRYWP-EDGDCDDH
|..||||.|.|. ..||| |   .... ||||.||. .||...|.||||||||..| .|||||||..   ||||.|...|.||.|| .||| |...   .
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

VDLRVQHV-ETQ-EYEDHVERIFTIDHVQTGQ-SRTIIHFQMTSWPDFGVPSSAESCLHILGLVRQAQasavlamgpswkgHPSGPPIVVHCSAGIGRTG
 |..|. . ... . .. . | ..... .. . .|.. ....|.||| |||.|..| |...  |.. .             ...  |.|||||||.||||
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.............eaksgpvvVhCsaGvgRtg

TFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLE
||..||| ...|..|.  .....|| ||.||..|.|. |||.|.. |.||
tfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_PTPRA_pd Subfamily PTPRA 327-599 8.8e-76 249.9 In-house 34-296 (330) alignment 
Range on Protein: 327-599
Range on HMM: 34-296/330.0
IRRQYLELRNMPVEGTFLRTKLRANLRKNRYTDVLCVEETRVPLSPVDEDDCSDYIHANFTDGYRQHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMIT
.| ..  |   |...|.  ..   | .|||. ..|  . .|| ||...  ..|||| | | |||.. . |||.|||. .|  |||||.||| .. |||.|
freefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmlt

RCMERGRVKCRRYWPEDGdCDDHVDLRVQHVETQEYEDHVERIFTID----HVQTGQSRTIIHFQMTSWPDFGVPSSAESCLHILGLVRQAQASavlamg
   || . || .|||..| .  . ..||.  .... .|   | | .     . .  .|| .  | .|||||.|||. .   |..|  |.. .        
elkerkeekcaqywPdeG.lvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqq......

pswkghPSGpPIVVHCSAGIGRTGTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEFAL
       .| |||||||||.||||||..||  . |.. |.. .. ..|| ||.||..|.|| |||||.. ..||. |
......sag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyyl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 317-597 2.5e-75 248.2 In-house 13-278 (288) alignment 
Range on Protein: 317-597
Range on HMM: 13-278/288.0
AHVKGLGRRGIRRQYLELRNMPVEGTFLRTKLRANLRKNRYTDVLCVEETRVPLSPVDEDDCSDYIHANFTDGYRQHKAFIATQGPLPNTTSDFWRMVWE
|. .  .| |. ..|  | ..  . .   ..|  | .|||| ..| ..|.|| |  ..| . .||| |.. ||....|..|||||||..|  |||..|.|
akksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvye

QGAMVIVMITRCMERGRVKCRRYWPEDGDCDDHVDLRVQHVETQEYEDHVERIFTIDhvQTGQSRTIIHFQMTSWPDFGVPSSAESCLHILGLVRQAQAS
. .  |||.|  .|.|. || .|||....   . .. |. ||..| ||.|.| . ..  .... ..| ..| ..||| ||| |..  |..|  | .|. .
nktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqa

AvlamgpswkghpsGPPIVVHCSAGIGRTGTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEF
                ||.||||||.|||||| .||  . ....| . ....||. || ||| ..|| .||||.. ..|. 
d.............tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 324-597 4.9e-75 247.2 In-house 14-275 (281) alignment 
Range on Protein: 324-597
Range on HMM: 14-275/281.0
RRGIRRQYLELRNMPVEGTFLRTKLRANLRKNRYTDVLCVEETRVPLSPVDEDDCSDYIHANFTDGYRQHKAFIATQGPLPNTTSDFWRMVWEQGAMVIV
 .|  ..| .|... |. |   .|  .|  ||||...   . ||| ..| .|.  .||| ||| .||...|..||||||.|..  .||.||||| . .||
naGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaiv

MITRCMERGRVKCRRYWPEDGDCDDHVDLRVQHVETQEYEDHVERIFTIdHVQTGQSRTIIHFQMTSWPDFGVPSSAESCLHILGLVRQAQASAVLamgp
|.|| .| |..|| ||||.|       |..|......| . ..|| |.. . ..|..|.. ... |.||| |||....  |.    |.... .       
mvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktk....

swkghpsgPPIVVHCSAGIGRTGTFCTLDINVSRLQHE-GVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEF
         |.|.|||||.|||||. .||  |.....|    .. ..|. || .|  |.||  |||| ..|||. 
........aplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavlda
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 347-598 1.8e-74 245.7 In-house 52-290 (298) alignment 
Range on Protein: 347-598
Range on HMM: 52-290/298.0
KLRANLRKNRYTDVLCVEETRVPLSPVDEDDCSDYIHANFTDGYRQHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITRCMERGRVKCRRYWPEDGDc
. ..| .||||.|.. .. .|| |. .|.|. |||| | | ..|....||||||.||..|..||||||.|. . .|||.|   | ...|. .|||..|  
rkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegk.

DDHVDLRVQHVETQEYEDHVERIFTIDHVQTGQSRTIIHFQMTSWPDFGVPSSAESCLHILGLVRQAQASAvlamgpswkghpSGPPIVVHCSAGIGRTG
. . ...|.  ...|. | . | ... . .. ..|.. ....||||| |||. |.| |..|  ||. |  |               |..|.||||.||.|
etygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqa............gnkpvivqCsaGvgRsG

TFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEFA
||. .|  . |...| | .. ..||.||..|....|| ||| |.. ||||. 
tfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleal
0037934 (Phosphotyrosine protein) phosphatases II 345-597 2.1e-73 242.1 In-house 4-241 (243) alignment 
Range on Protein: 345-597
Range on HMM: 4-241/243.0
RTKLRANLRKNRYTDVLCVEETRVPLspvdeDDcSDYIHANFTDGYRQhkaFIATQGPLPNTTSD----FWRMVWEQGAMVIVMITRCMERGRVKCRRYW
  .| .|| ||||.|.|. . .|| |     .. ||||.||.......   .||||||||.|. |    ||||.||.|  ||||.|...|.||.|| .||
iallpenlsknrysdilpydhsrvkl.....eg.sdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PedGDCdDHVDLRVQHVETQEYEDHVERIFTIDHVQ-TGQSRTIIHFQMTSWPDFGVPSSAESCLHILGLVRQAQASAVlamgpSWKGHPSGPPIVVHCS
|  |.   . |..|. .......| . | ... ... ....|..||.. ..|||.|||.| |..| .|  ||. . ...     |.   .|| |..||||
p..gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieell.....sllaldsggpvlVHCs

AGIGRTGTFCTLDINVSRLqheGvCEIVNTVKYLRTQRAH-MIQTPEQYEFCHLAVLEF
||.|||||......  ..|   | . . ..||.||.|| . ..|||.||.|.. |.||.
aGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_PTPRG_pd Subfamily PTPRG 312-599 3.2e-73 241.8 In-house 3-288 (563) alignment 
Range on Protein: 312-599
Range on HMM: 3-288/563.0
IMEFLAHVKGL---GRRGIRRQYLELRNMPVEG--TFLRTKLRANLRKNRYTDVLCVEETRVPLSPVDEDDCS-DYIHANFTDGYRQHKAFIATQGPLPN
. ||  ||  |   |  |. ... .| .  ..   .   .. . | |||||.... ....|| |||. . . . ||| ||. |||...||||||||||..
vkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkd

TTSDFWRMVWEQGAMVIVMITRCMERGRVKCRRYWPEdGDCDDHVDLRVQHVETQEYEDHVERIFTIDH--VQTGQ----SRTIIHFQMTSWPDFGVPSS
|. |||||.||| . .|||||   |||| || .|||.  .  .   |.|. .|..      .| ..| .  .. ..     ........|.||| |||..
tfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPeh

AescLHILGLVRQAqasavlamgpSWKGHPSGPPIVVHCSAGIGRTGTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEFAL
.   |  |  |...          |   .    |||||||||.|||||.. ||  . ..|.| . .. ...| .|.|| ...|| ||| | | |.||  .
s...lpvLifvkks..........saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaia
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 320-601 9.1e-71 233.5 In-house 17-286 (305) alignment 
Range on Protein: 320-601
Range on HMM: 17-286/305.0
KGLGRRGIRRQYLELRNMpVEGTFLrTKLRANLRKNRYTDVLCVEETRVPLSPVDEDDCSDYIHANFTDGYRQHKAFIATQGPLPNTTSDFWRMVWEQGA
.    .|.  || .| .   | ... .|  || .|||....   .. |. |.. ...| |||| |.. |||...|..|..||||.|| .||||...|   
rvysdkgleaqykslyee.eesidv.gkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekv

MVIVMITRCMERGRVKCRRYWPEDGDC-DDHVDLRVQHVETQEYEDHVERIFTIDH-VQTGQSRTIIHFQMTSWPDFGVPSSAESCLHILGLVRQAQASA
 .|||.|. .| |. |||.||||      .. .. |.  ......|..|| ..|    .  .|||....|.|.||| ||| .| | |...  |...| . 
stivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkd

vlamgpswkghpSGPPIVVHCSAGIGRTGTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEFALSL
             | |..||||||.||||.|...|| . ||..|.| .. . .| ||..|  |.|| .|| |.| |. |   . 
............kgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 336-598 2.5e-70 231.7 In-house 13-268 (274) alignment 
Range on Protein: 336-598
Range on HMM: 13-268/274.0
NMPVEGTFLRTKLRANLRKNRYTDVLCVEETRVPL-SPVDEDDCSDYIHANFTDGYR-QHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITRCMERGR
..|.. .   ...  . .||||...|  |..|| | |   ||. |.|| ||.  ||. ..||..||||||||| .|||||.... . ||||.|.  |. .
elPlnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeane

VKCRRYWPEDGDC---DDHVDLRVQHVETQEYEDHVERIFTIDHVQTgqSRTIIHFQMTSWPDFGVPSSAESCLHILGLVRQAQASAVLAMGPSwkghps
 || .|.|.. |.   . . |. .. ... | .|.  | ... ...   .|...|.  |.|||  .| .|.. |...  |.... ..   ..|       
qkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapv......

gppiVVHCSAGIGRTGTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEFA
    |||||||||||| | . .| | .|..|.| .....|  || .|  |.|| ||||. | |. ...
....vvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclyl
subfamily_Ptp69D_pd Subfamily Ptp69D 326-598 8.1e-70 230.4 In-house 23-286 (307) alignment 
Range on Protein: 326-598
Range on HMM: 23-286/307.0
GIRRQYLELRNMPVEGTFLRTKLRANLRKNRYTDVLCVEETRVPLSPVDEDDCSDYIHANFTDGYRQHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMI
|. . | .| .  .. .   ..   |. |||| |.   ..||| |...  .. |||| |.|  ||...| ||| |.|. .|  |||||..||   .|||.
glakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivml

TRCMERGRVKCRRYWPEDgDCDDHVDLRVQHVETQEYEDHVERIFTIDHVQ-----TGQSRTIIHFQMTSWPDFGVPSSAESCLHILGLVRQAQASAvla
.   |  | || .|||.. |   . |. |. |.... .|...| . . ...       .|| .. .. |.|.|. || .|.. |...  ||. .      
snlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln...

mgpswkghpsGPPIVVHCSAGIGRTGTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEFA
            ||||||||| ||.|.| .||. . .|. |   .|..||| || ||  ..|  |||.|.. |.|.. 
..........rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldys
subfamily_PTPN13_pd Subfamily PTPN13 330-597 2.6e-69 228.5 In-house 16-268 (273) alignment 
Range on Protein: 330-597
Range on HMM: 16-268/273.0
QYLELRNMPVEGTFLRTKLRANLRKNRYTDVLCVEETRVPLSpvdeD--DcsdYIHANFTDGY--RQHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMI
.. |||..    |   .| ..| .|||| .|| ..||||.|.    |      || |..       ..  .||.|||||.|..|||.||||| | ||.|.
efkelrelkpldtcevgkkkenkdknryrnvlPydetrvklg....degg...yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamv

TRCMERGRVKCRRYWPEDGDCDDHVD--LRVQHVETQEYEDHVERIFTIDHVQTGQSRTIIHFQMTSWPDFGVPSSAESCLHILGLVRQAQASAVlamgp
|   |.|.|||.|||||  .    |   |.|. ...|.... | | ... ....|.|| . |.....||| ||||||.. |...  ||. | .|      
tlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdag.....

swkghpsgpPIVVHCSAGIGRTGTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEF
         ||||||||||||.||. |.|. .  ....   .. ..|. || ||  ..|| .|| |.. |.|| 
.........PivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailev
subfamily_PTPN12_pd Subfamily PTPN12 349-598 7.5e-69 226.8 In-house 38-277 (290) alignment 
Range on Protein: 349-598
Range on HMM: 38-277/290.0
RANLRKNRYTDVLCVEETRVPLSPVDEDDCSDYIHANFTDGYRQHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITRCMERGRVKCRRYWPEDGDCDD
  | .|||| |.|  ...|| ||  .|.. |||| |||  |  .....||.|||||.| .|||||.||.   ..||. | .| |. ||.||||| |. . 
eenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeel

-HVDLRVQHVETQEYE-DHVERIFTIDHVqtGQSRTIIHFQMTSWPDFGVPSSAESCLHILGLVRQAQAsavlamgpswkghPSGPPIVVHCSAGIGRTG
 . ...|.  | .  . |.. | .....   ..||..  |. |.||| ||||||.| |... |||. |               .  |.|||||||.||||
efgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.............sedaPlvvhCsaGvGrtG

TFCTLDINVSRLQHEGV---CEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEFA
| ...|.  . |..| .    .. . |  ||.||| ..|| ||||. . ||.|. 
tiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_PTPN6_pd Subfamily PTPN6 319-597 1.6e-68 226.0 In-house 20-296 (306) alignment 
Range on Protein: 319-597
Range on HMM: 20-296/306.0
VKGLGRRGIRRQYLELRNMPVEGTFLRTKL--RANLRKNRYTDVLCVEETRVPLSpVDEDDCSDYIHANFTDGY--RQHKAFIATQGPLPNTTSDFWRMV
 . |.. |.  .. ||... .. .. |..     | .||||  .| ...||| |.  ..   |||| ||. ..    ..|..||||| |..| |||||||
eeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmv

WEQGAMVIVMITRCMERGRVKCRRYWPEDGDCDDHVDLRVQHVETQEYEDHVERIFTIDH-VQTGQSRTIIHFQMTSWPDFGVPSSAESCLHILGLVRQA
|.. . ||||.|. .|||. || ||||.  . ... ...|..|. .. .| . | ... .  . ...|...... .|||| |||.. .  |. |  |.. 
wqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrk

QASAVlamgpswKGhPSGpPIVVHCSAGIGRTGTFCTLDINVSRLQHEGV---CEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEF
| .         .   .| ||||||||||||||||  .|| .. ....|.   ..| ..||..|.||  ..|| .|| | . |. ..
qeele.......ea.eag.pivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikky
subfamily_PTPN3_pd Subfamily PTPN3 344-595 4.6e-68 224.2 In-house 34-272 (280) alignment 
Range on Protein: 344-595
Range on HMM: 34-272/280.0
LRTKLRANLRKNRYTDVLCVEETRVPLSpvdEDDCsDYIHANFT----DGYRQHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITRCMERGRVKCRRY
  ... .|| |||| |.|  ..||| |.   | .  ||| ||.     ..  . . .|||||||..|..|||.||||| . .|||.|  .||||||| .|
saarkpenlsknryrdilpydatrvklk...eset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqy

WPEDGDCDDHVDLRVQHVETQEYEDHVERIFTIDHVQTGQSRTIIHFQMTSWPDFGVPSSAESCLHILGLVRQAQasavlamgpswkgHPSGPPIVVHCS
||| .|  .. ...|.  ...| . .| | ... . .| ..|.|...| ..||| |||..... |...  ||...             . .  |.|||||
WPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr.............sgkeePvvvhCs

AGIGRTGTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVL
||||||| . .|.. .. ....    ... |. .| ||| ..||..||.|   |.|
aGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeail
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 351-598 9.9e-68 223.0 In-house 20-264 (270) alignment 
Range on Protein: 351-598
Range on HMM: 20-264/270.0
NLRKNRYTDVLCVEETRVPLSPVDEDDCSDYIHANFTDGYR-QHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITRCMERGRVKCRRYWPEdgDCDDH
. . |||.|.|   .||| |....||. . || ||.  |.  ..|..||..||||.|...||||.||. .  |||.|  .|.|| || ||||.  . ...
gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpa..epkek

VDLRVQHVETQEYEDHVERIFTIDHV---QTGQSRTIIHFQMTSWPDFGVPSSAESCLHILGLVRQAQAsavlaMGPSWKGHPSGPPIVVHCSAGIGRTG
|.|.  ....   ... |. . . ..   ..|..| ..||....||| |||....| |.   |..  .|     .  | | .  . |..||||||.||||
vkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlra.....vrrsekeldkaePllvHcsaGvgRtG

TFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEFA
|. .||| |  |.... ..... .. || .|  ..|.|||||| . ||.|.|
tlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveya
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 349-599 1.3e-67 222.6 In-house 7-243 (250) alignment 
Range on Protein: 349-599
Range on HMM: 7-243/250.0
RANLRKNRYTDVLCVEETRVPLSPVDEDDCSDYIHANFTDGYRQHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITRCMERGRVkCRRYWPEDGdCDD
 .|. ||||.|.. ....|| | ... |. |||| | | .||...||||||||||..|. ||||||.|. . .|||.|   | ... . .||| ..  . 
pqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek.aek

HVDLRVQHVETQEYEDHVERIFTIDHVQTGQSRTIIHFQMTSWPDFGVPSSAESCLHILGLVRQAQASAvlamgpswkghpSGPPIVVHCSAGIGRTGTF
. |..|.  ...|. | . | . . . .  ..|.. ... ..||| |||  |.. |..|  |.. |  |               |..|.||||.||.|.|
yGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqa............gnaPvivqCsaGvgrsGaf

CTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEFAL
...|  . ||..| | .. . .| ||..| |.... ||| |.. ..|..  
iaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald
subfamily_PTPN23_pd Subfamily PTPN23 349-598 4.3e-66 217.7 In-house 41-280 (288) alignment 
Range on Protein: 349-598
Range on HMM: 41-280/288.0
RANLRKNRYTDVLCVEETRVPLSpvdeDDCSDYIHANFTDGYRQ-HKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITRCMERGRVKCRRYWPED-GDC
. .  |||..|.|  ...|| |     .   ||| | |  .       |||||.||..| .|||.||.|| . ||||..   |.|. |. |||||| |. 
klyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkget

DDHVDLRVQHVETQEYEDHVERIFTIDHVQTGQSRTIIHFQMTSWPDFGVPSSAESCLHILGLVRQAQASAVLAMGPswkghpsgpPIVVHCSAGIGRTG
  . ||.|   ...| | ||||...... .. . ... | |.||||..|||.| |. |..|. |..|  .    .           |.|||||||.||||
vkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrkskt.........PlvvhCsaGvgRtg

TFCTLDINVSRL-QHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEFA
.|. .   |  | ...|. .|.. |. ||.|| .|.|. ||..|.  |||| |
vfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 312-597 7.9e-64 210.3 In-house 7-282 (290) alignment 
Range on Protein: 312-597
Range on HMM: 7-282/290.0
IMEFLAHVKGLGRRGIRRQYLELRNMPVEGTFLRTKLRANLRKNRYTDVLCVEETRVPLSPVDED-DCS-DYIHANFTDGYRQHKAFIATQGPLPNTTSD
  ||.|. .  |..| | |.  | .   | |  .     | ..||.....  .. |..| |. .. ||. .||.| . .||...|..||||||..||  |
fgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvd

FWRMVWEQGAMVIVMITRCMERGRVKCRRYWPEDgDCDDHVDLRVQHVETQEYEDHVERIFTIDHVQT-GQSRTIIHFQMTSWPDFG-VPSSAEScLHIL
||...|..   .|||.|  .| |.|||. |||.  | ..    ... .. ..... .|| . . . .. |........|.|.|.. | |.  . . |...
FWkliwqekvtiivmltniieegkvkCqqYWpds.dtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqti.llvi

GLVRQAQasavlamgpsWKghPSGPPIVVHCSAGIGRTGTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEF
  . . |          .|  .   .||||||...||...||.... . . . ||| .... .| .|.|.  ..|| .||.. .  ||. 
eemyktq..........rk..rgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlty
subfamily_PTPN1_pd Subfamily PTPN1 340-601 9.6e-64 209.9 In-house 21-274 (290) alignment 
Range on Protein: 340-601
Range on HMM: 21-274/290.0
EGTFLRTKLRANLRKNRYTDVLCVEETRVPLSPVDEddcsDYIHANFTDGYRQHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITRCMERGRVKCRRY
. .   .|| .|  .||| ||   . .|. |   |     ||| |.. .  . .. .| ||||||||.. ||.||||| .  .||. ...|....|| .|
dfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqy

WPEDGD----CDDHVDLRVQHVETQEYEDHVERIFTIDHVQTGQSRTIIHFQMTSWPDFGVPSSAESCLHILGLVRQAqasAVLAmgpswkgHPSGpPIV
||.. .      ... |.|. ....... .. |.. .. ..| ..|.|.||  |.|||||||.|  . |. |  ||..    .|.       .  | | |
wPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvres...Gsls.......sdvG.pav

VHCSAGIGRTGTFCTLDINVSRLQHEGV---CEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEFALSL
.||||||||.|||| .|  . ......    ..| ...  || .|  .|||..| .| .||.|| |  .
ihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvi
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 333-597 5.4e-63 208.2 In-house 42-290 (319) alignment 
Range on Protein: 333-597
Range on HMM: 42-290/319.0
ELRNMPVEGTFL-RTKLRANLRKNRYTDVLCVEETRVPLSPVDEDDCSDYIHANFTDGYRQHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITrcmer
 . ...|...    . |  |  |||....|  ....| | ...  . |||| | | .||.... .||.||||.||  |||||.||. .  ||..|     
racklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt.....

gRVKCRRYWPEDGDCD-DHVDLRVQHVEtqEYEDHVERIFTIDH-VQTGQSRTIIHFQMTSWPDFGVPSSAESclhILGLVRQAQASAvlamgpSWKGHP
 . || .||| ...   .. ...|. ||  | ...| | . . .  .  . | |  | .  ||| ||| ..     .. ||.. .         | . |.
.kdkcsqywplkivikeerfkvkvdsve..etaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsd...lmrlvkkvrhlt......skenhr

SgpPIVVHCSAGIGRTGTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEF
   .||||||||.||||.. .||. ..|...|   .. |.|. || || ...|   || |.. |.|| 
a..nivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysallee
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 336-597 3.6e-62 205.4 In-house 9-254 (284) alignment 
Range on Protein: 336-597
Range on HMM: 9-254/284.0
NMPVEGTFL-RTKLRANLRKNRYTDVLCVEETRVPLSPVDEDDCSDYIHANFTDGYRQHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITrcmergRV
...|.||    . |  |  |||....|  ....| | ...  . |||| | |  ||.... .|||||||.||  |||||.||. .  ||..|      . 
klgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kd

KCRRYWPEDGDCD-DHVDLRVQHVEtqEYEDHVERIFTIDH-VQTGQSRTIIHFQMTSWPDFGVPSSAESclhILGLVRQAQASAvlamgpSWKGHPSgp
|| .||| ...   .. ...|. ||  | |..| | . . .  .  . |.|  | .  ||| ||| ..     .. ||.. .         | . |..  
kcsqywplkivikeerfkvkvdsve..eseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsd...lmrlvkkvrhlt......skenhra..

PIVVHCSAGIGRTGTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEF
.||||||||.||||.. .||. ..|...|   .. |.|. || || ...|   || |.. |.|| 
nivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysallee
subfamily_PTPN14_pd Subfamily PTPN14 331-597 4.3e-62 204.8 In-house 29-295 (300) alignment 
Range on Protein: 331-597
Range on HMM: 29-295/300.0
YLELRNMPVEGTFLRTKLRANLRKNRYTDVLCVEETRVPLSPVDEDdCSDYIHANFTDG--YRQHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITRC
| .. ..  ....  .||  | .|||. |||  |..|| |||  |.  ..|| |         ... .|..||||..|  |||.||||||  .|||.|. 
yeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmltee

MERGRVKCRRYWPEDGDCDDHVDLRVQHVETQEYED---HVERIFTIDHVQTGQSRTIIHFQMTSWPDFGVPSSAESCLHILGLVRqaqaSAVLAMGPSW
 | |. |. .|.|....  ..|.    .| |.  ||    . . ... |. ... ||..|.| | ||| |||.  .. |. |  |.    |   ..  . 
eedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevq....svrrktnsev

KGHPSGPPIVVHCSAGIGRTGTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEF
... | ||..||||||.||||   . |. .. |.|. . .| .... ||.|| ...||  ||.| . .....
eskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvliky
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 347-600 1.2e-59 197.0 In-house 44-290 (325) alignment 
Range on Protein: 347-600
Range on HMM: 44-290/325.0
KLRANLRKNRYTDVLCVEETRVPLSPVDEDDCSDYIHANFTDGYRQHKAFIATQGPLPNTTSDFWRMV--WEqgaMVIVMITRCMERGRVKCRRYWPED-
 . .|  |||. .|. ....|| |   ..|  |||| |..   ... . |.|.| ||..|. |.||.|  |.     .|...  .. |  .|  |||.. 
mkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr...csvvvvlneldlgkdrcavywpkem

GDCDDHVDLRVQHVETQEYEDHVERIFTIDHVQTGQSRTIIHFQMTSWPDFGVPSSAESCLHILGLVRQAQAsAVLAmgpswKGHPSGpPIVVHCSAGIG
|.      |.|. .  .|. |.| |.. .  |. |..|..  ||. ||.|.||.    . . || || . .   | |     . . |. ||.||||||.|
gksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavse.rvta.....ntkast.pilvhcsaGvG

RTGTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEFALS
|||.| .|   . .. .|   .| . || || .|  |..| .|| ... |. |. .|
rtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveayms
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 315-597 2.1e-59 196.0 In-house 14-278 (315) alignment 
Range on Protein: 315-597
Range on HMM: 14-278/315.0
FLAHVKGLGRRGIRRQYLELRNMPVEGtFLRTKLRANLRKNRYTDVLCVEETRVPLSPVDEDDCSDYIHANFTDGYRQHKAFIATQGPLPNTTSDFWRMV
..|. |   . |....|  .    .   .  .|   | .|||| ...  ...|| |  .. |. |||. ||| ||| ... .||.|||....  ||||.|
yvaqkkastkngfkqdyesipggqlhp.ldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlv

WEQGAMVIVMITRCMERGRVKCRRYWPEDgdCDDHVDLRVQHVETQEYEDHVERIFtiDHVQTGQSRTIIHFQMTSWPDFGVPSSAESCLHILGLVRQAQ
.|.    |||.|  .|. . |. .|||..     .  . | ... . ...   | .    |   . |... ...||||| ||| .. . ...   |.| .
feedigkivmltnlvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhh

ASAVlamgpswkghpsgPPIVVHCSAGIGRTGTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEF
 ..|              .||||||||.||||||.|||  . ... | . .. | .. .| .| .|.|. |||.| . |.|| 
tnsv.............gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydallet
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 348-598 4.2e-58 191.6 In-house 41-277 (315) alignment 
Range on Protein: 348-598
Range on HMM: 41-277/315.0
LRANLRKNRYTDVLCVEETRVPLSPVDEDDCSDYIHANFTDGYRQHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITRCMERGRVKCRRYWPE-DGDC
 . | .|||| ..| ....|| |  .|..  |||| | .  .. . ||.||.||||. . .||||||... .  |||.|   |  ..|||.|||. ..| 
etinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkads

DDHVDLRVQHVETQEYEDHVERIFTIDhvQTGQSRTIIHFQMTSWPDFGVPSSAEsclHILGLVRQAQASAvlamgpSWKGHpsgpPIVVHCSAGIGRTG
 .   ..|. ....   | | | ...   .. .|||.  ||.| ||| ||.  .     .| |... .|.         | .    ...||||||.||||
vefGsikvellsleadtdgvarklvtr..kseesrtvtqfqftewPdkGvdkqts...sllklikevkadn......gkkef....sllvhcsaGvGrtG

TFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEFA
 ....|  |...... . .. |.|| ||..| ...|| |.| | . ||||  
vvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledl
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 350-598 1.1e-57 190.3 In-house 42-276 (515) alignment 
Range on Protein: 350-598
Range on HMM: 42-276/515.0
ANLRKNRYTDVLCVEETRVPLSPVDEDDCSDYIHANFTDGYRQHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITRCMERGRVKCRRYWPE-DGDCDD
 | .|||| ..|  . .|| |  ....  |||. | .  ..   ||.||.|||.. ...||||.|...    |.|.|.  |  ..|| .|||.  ||   
infkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvk

HVDLRVQHVETQEYEDHVERIFTIdhVQTGQSRTIIHFQMTSWPDFGVPSSAESCLHilgLVRQAQASAvlamgPSWKgHpsgpPIVVHCSAGIGRTGTF
   ..|. | ..   . . | .|.  ..  .|||.  |..| ||| |||  . | |    |... .|.        .. |    |...|||||.|||| .
fGsikvelvsleactggikrkltv..lkgddsrtvtqfhfteWPdkGvpkhtssllk...likevkadh.....gqyt.h....pliihcsaGvGrtGvv

CTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEFA
...|  |.. .   . .. |.|. .| .| ...|| ||| | . ||||  
isidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 311-597 5.5e-57 187.9 In-house 6-277 (287) alignment 
Range on Protein: 311-597
Range on HMM: 6-277/287.0
RIMEFLAHVKGLGRRGIRRQYLELRNMPVEGTFLRTK-LRANLRKNRYTDVLCVEETRVPLSpvdeDDCSDYIHANFTDGYRQHKAFIATQGPLPNTTSD
.. || |. .  |. | . |.  | ..  .   .  .    |  |||.|..|  .. ||.|     .   ||| | | |||...||||....|. ||  .
kfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarn

FWRMVWEQGAMVIVMITRCMERGRVKCRRYWPEDGDcDDHVDLRVQHVETQEYEDHVERIFTIDHVQ-TGQSRTIIHFQMTSWPDFG-VPSSAESCLHIL
||......   .|||... .|  . .| .||||.       . ... .. . ... .|| . . . . .|. ...  .|.|.|.. | |.. . . | | 
fWkliddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvie

GLVRQAQasavlamgpswkgHPSGPPIVVHCSAGIGRTGTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEF
  ... .             ...  .||||||...||...||  .. . . . ||| .... .|  | |. ...|| |||.|   .|||.
emyktqr.............krgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivley
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 345-600 1.7e-56 186.6 In-house 45-286 (297) alignment 
Range on Protein: 345-600
Range on HMM: 45-286/297.0
RTKLRANLRKNRYTDVLCVEETRVPLSPVDEDDCSDYIHANFTDGYRQhkAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITRCMERGRvKCRRYWPEDG
 .. . |. |.||...| ..  || |  |..|  |||. | |  |...   .|.|| | ..|  |||.||... . .|||..   || . ||.|||...|
vaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkg

DCDdHVDLRVQHVETQEYEDHVERIFTIDHVQTGQSRTIIHFQMTSWPDFGVPS--SAESCLHILGLVRQaqasavlamgpSWKGHPSGpPIVVHCSAGI
      |. |.   ..| |  ..| ... . .. . | .  .| ..|||  |.   ||.| |...  ||.           ..... .| |..|||.||.
vtt.fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrk...........dfsqnaeg.PllvhclaGv

GRTGTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEFALS
|||| ..|.|  |.. ..|   .| ..|| || .| ...|| |||.| . ||||. ||
Grtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlealls
subfamily_PTPRN_pd Subfamily PTPRN 345-596 1.6e-55 182.9 In-house 50-290 (297) alignment 
Range on Protein: 345-596
Range on HMM: 50-290/297.0
RTKLRANLRKNRYTDVLCVEETRVPLSPVDEDDCSDYIHANF-TDGYRQHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITRCMERGRVKCRRYWPED
 .|   |..|||...||  ...|| |.   ... |||| | . .|   .. |.|||||||..| .|||.||||||..|||..||  | |  .|.||||..
vakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpde

GDCDDHVdLRVQHV-ETQEYEDHVERIFTIDHVQTGQSRTIIHFQMTSWPDFGVPSSAESCLHIlglVRQAQAsavlamgpSWKGHPSgpPIVVHCSAGI
|    |.   |. | |    .|.. | | .  .|| ..||.  |   |||. |||.|| | |.     |. .         |..|  .  |||||||.| 
Gsevyhi.yevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllef...rrkvnk........syrGrsc..pivvhcsdGa

GRTGTFCTLDINVSRLQHeGVC--EIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLE
||||... .|. ..||.. ||   .|. |...|| ||.....| .|.||.  || |
GrtGvyilidlvlnrllk.Gvkeidiaatlehlrdqrpglvktkdqfefaltavae
0051429 (Phosphotyrosine protein) phosphatases II 378-617 2.3e-54 180.2 In-house 3-244 (272) alignment 
Range on Protein: 378-617
Range on HMM: 3-244/272.0
CSDYIHANFTDGYRQ---HKAFIATQGPLPNTTSDFWRMvWEQGAMVIVMITRCMERGRVKCRRYWP-----------EDGDCDDHVDLRVQHVETQEYE
 |.||.|.. .|| .    .......||||.|  ||||. .|.|  .||......||||.|| ||||           ..     . .||| ..... ..
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

DHVERIFTIDHV-QTGQSRTIIHFQMTSWPDFGVPSSAesCLHILGLVRQaqasavlamgpswkghpsGPPIVVHCSAGIGRTGTFCTLDINVSRLQHEG
|.. | ... .. ..|..|.. |...|.|||.|||..|  .|..| |...                  | |..||||||..||||.. |.. . .. .| 
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld..................ggpvlvHCsaGkdRTGtvvallllllgvslet

VCE--------IVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEFALSLPSINGEDKQRIKEFLH
...        . ..|..|| ||....||.|||.|.. |.||.. || |.. |  ... ....
ivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrsllsvraeyllaaldaid
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 347-596 4e-53 175.0 In-house 3-238 (239) alignment 
Range on Protein: 347-596
Range on HMM: 3-238/239.0
KLRANLRKNRYTDVLCVEETRVPLSPVDEDDCSDYIHANFTDGYR-QHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITRCMERGRVKCRRYWPEDgd
| | |  ||||....  . .|| |  . .|  |||| |..   |    ||.||||| .  .. |||||.|..   ||||.|  .|  . ||..|||.   
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds..

CDDHVDLRVQHVETQEYEDHVERIFTIDHVQTGQSRTIIHFQMTSWPDFGVPSSAESclhILGLVRQAQASAVlamgpswkghPSGPPIVVHCSAGIGRT
   ...|||   .|. . |.. | | . .|   . | . ....| ||| |||  | .   .||| |.    ..          |   | |.|||||.|||
tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyata...vlglrrkitkdsl..........pgarpwvihcsagvgrt

GTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLE
|.|  .|  . . ...   .|.| || .| .| ||.|| ||| | ||||||
gaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 343-597 5.1e-53 174.7 In-house 30-276 (287) alignment 
Range on Protein: 343-597
Range on HMM: 30-276/287.0
FLRTKLRANLRKNRYTDVLCVEETRVPLSPvDEDDCSDYIHANFTDGYRQHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITRCMERGRVKCRRYWPE
| ...  |. .||||.||| ...||| ||  . .  |||| ||.  .|....||||.|||.. |  ||||.|.|. . .....|| .| .| || .||||
fkaaeelaavkknryadvlPiddtrvllsa.egelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPe

DgDCDDHV-DLRVQHVETQ-EYEDHVERIFTIDHVQTGQSRTIIHFQMTSWPDFGVPSSAesclhiLGLVRQAQASaVLAMGPSWKGHPSGPPiVVHCSA
  .    |    |  .. .    ..  | . . ...| ..| .  ... |||| ... .|      .||.| .       .  . ..   ||. |||...
r.evPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPta......vglirfvldv.kqhielardasevGPl.vvhddv

GIGRTGTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEF
||||.|.. .. . ||||.  |  .. ..| .|| .|| ..|.. |. .   |.  .
GiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvty
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 347-596 5.5e-53 174.6 In-house 4-239 (239) alignment 
Range on Protein: 347-596
Range on HMM: 4-239/239.0
KLRANLRKNRYTDVLCVEETRVPLSPVDEDDCSDYIHANFTDGYR-QHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITRCMERGRVKCRRYWPEDgd
| | |  ||||....  . .|| |  . .|  |||| |..   |    ||.||||| .  .. |||||.|..   ||||.|  .|  . ||..|||.   
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds..

CDDHVDLRVQHVETQEYEDHVERIFTIDHVQTGQSRTIIHFQMTSWPDFGVPSSAESclhILGLVRQAQASAVlamgpswkghPSGPPIVVHCSAGIGRT
   ...|||   .|. . |.. | | . .|   . | . ....| ||| |||  | .   .||| |.    ..          |   | |.|||||.|||
tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyata...vlglrrkitkdsl..........pgarpwvihcsagvgrt

GTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLE
|.|  .|  . . ...   .|.| || .| .| ||.|| ||| | ||||||
gaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
0041856 (Phosphotyrosine protein) phosphatases II 351-599 1.2e-52 173.5 In-house 1-172 (182) alignment 
Range on Protein: 351-599
Range on HMM: 1-172/182.0
NLRKNRYTDVLCVEETRvplspvdeddCSDYIHANFTDGYRQHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITrcmergrvkCRRYWPedgdcddhv
|| ||||.|.|... .|           .|||.||. .|.. .. ||||||||..|. ||.||..|.|  .||..|         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

dlrvqhvetqeyedhveriftidhvqTGQSRTIIHFQMTSWPDFGVPSsAESCLHILGLVRQaqasavlamgpswkghpSGPPIVVHCSAGIGRTGTFCT
                          .   |..|... ..|||.|||.  ...|...  |..                 .| |..||||||.|||||.. 
..........................ellerlgiqylylpwpDhgvpd.ldelldfieevle.................eggpvlVHCsaGvgRtgtlva

LDINVSRlqheGvCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEFAL
...  ..    | . . ..||..| .| .|..||.|| |..||.||. |
aylmkkl....g.vsleeavklvrsrRpgmvitpnqyfflqlallelll
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 341-596 7.1e-52 171.1 In-house 23-293 (297) alignment 
Range on Protein: 341-596
Range on HMM: 23-293/297.0
GTFLRTKLRANLRKNRYTDVLCVEETRVPLSPVDEDdcSDYIHANFTDG--YRQHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITRCMERGRVKCRR
..|  .|  . ||||||.|.| ...||| |  |  .  .||| |..       .   .| .|||| .|  |||..|.||.  ||||...  | || ||  
esfssakrnsslrknryrdilatddtrvkllrvite..rdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcap

YWPE-DGDCDDHVDLRVQHVETQEYEdhVER--IFTIDHVQTGQSRTIIHFQMTSWPDFGVPSSAESCLH--------------ILGLVRQAQASAVLAM
|||. ...     |. |... .   |   .|  .  .  .   .|| . | |  |||| ||||  |                  .|.||    |  .| .
ywpsvvqerlkagdvvveflsstsde..fdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflql

GPSWKGHPSGPPIVVHCSAGIGRTGTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLE
      .|   ...||||||.||.|     |. ...|... . ..   ...|| ||| ..|| ||.|... |||.
eslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 348-599 1.6e-50 166.6 In-house 30-267 (283) alignment 
Range on Protein: 348-599
Range on HMM: 30-267/283.0
LRANLRKNRYTDVLCVEETRVPLSPVDEddcsDYIHANFTD---GYRQHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITRCMERGRVKCRRYWPEDG
 . | ||||. ... ..  || | .  .    ||| | |      |.| | .|..|.|| .|  |||.||... .  |||.|. .|  |.|| .|||..|
adenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrG

DcDDHVDLRVQHVETQEYEDHVERIFTIDHVQTGQSRT-IIHFQMTSWpdfgvpSSAESCLHILGLVRQAQASAVLamgpswKGHPSGpPIVVHCSAGIG
   |. .. |   .    .  . . ... .  . .|   . |.|.  |       . .    |  ||.  .  .        . .. | |||||||.|||
s.edyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW......leygeqaiinslvkfnkvislq......teskkg.PivvhCstgiG

RTGTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEFAL
||..|...   |  .. | | .. ..|| .| ||  ..|| .|| . | .||| ||
rtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqal
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 353-596 6.8e-49 161.5 In-house 50-277 (439) alignment 
Range on Protein: 353-596
Range on HMM: 50-277/439.0
RKNRYTDVLCVEETRVPLSPVDEDDCSDYIHANFTDGYRQHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITRCMERGRvkcrrYWPEDGDCD-DHVD
 |||| ||   . ||| |  .     | || ||. .|| . | .||||||  .|| ||||.|.|. .. |||.|  .|  .     ||| |...    . 
tknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdia

LRVQ-HVETQEYEDHVERIFTiDHVQTGQSRTIIHFQMTSWPDFGVPSSAEsclHILGLVRQAQaSAVlamgpswKGHPSGpPIVVHCSAGIGRTGTFCT
.||.  .|  .|  .  ..|  .. .| . ||...|. ..|||  ||. |    |.| ..|  . ||          .  | |.|||||||.|||||  .
vrvdrnielpnyvirgfkvfn.erdttekertvlqfhyiawpdknvpaqas...hvldflrain.san.......dkeeyg.pvvvhcsagvGrtGtiia

LDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLE
||| . .|. |   .|   ||.|| || .|.|.  || | . ||||
ldialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle
0049772 (Phosphotyrosine protein) phosphatases II 336-605 8.4e-49 162.3 In-house 31-287 (314) alignment 
Range on Protein: 336-605
Range on HMM: 31-287/314.0
NMPVEGTFLRTKLRANLRKNRYTDVLCVEeTRVPLSPVDEDDcSDYIHANFTDGYrqhKAFIATQGPLPNTTSDF----------WRMV--WEQGAMVIV
....|.|.|  .| .|  ||||.|.|... .|| |. .. .. ||||.|.. ||.   ..||||||||..|  ||          ||||  ...   .||
svlpeltilvadlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdiv

M---------------------ITRCMERGrvkcrrywpedgDCDDHVDLRVQHvetqeyedhvE-------RiftidhvqtgqSRTIIHFQMTSWPDFG
|                     .......|            .  .  ||   .          |                   .|..|..  . .||..
msrdevladelsrLdaAlgKtpllildgng............neptaadlellk..........eelydpelf...........erlgikylripvpDgs

VPsSAESCLHILGLVRQAqaSavlamgpswkghpSGPPIVVHCSAGIGRTGTFCTLDINVSRLqheGVcEIVNTVKYLRTQRA-----HMIQTPEQYEFC
.| . |  ...| ....|  .              | |..|||.||.||||||..... ...|   ||  .  .....| .|      ..|...|||||.
ap.lledfdeflefieea..d.............kggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefi

HLAVLEFALSLPSIN
. |.||.   |.. .
lealleylkflkkfy
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 317-596 1.6e-48 159.8 In-house 19-281 (290) alignment 
Range on Protein: 317-596
Range on HMM: 19-281/290.0
AHVKGLGRRGIRRQYLEL-RNM-PVeGTFLRTKLRANL--RKNRYTDVLCVEETRVPLSpvDEDDcSDYIHANFTDGYRqhKAFIATQGPLPNTTSDFWR
..|   .  .. ..|||  .   || . . |  . .|   .|||| || | . ||| |.  |  |  ||.|||. .| .    || |||.| .|. |.||
sdvvkknvdelakeyleklkpylpv.qylerkifdkntefkknrykdvvcndktrvilk..dGyd.GdyvhanyvkGlk..amfiltqGalkdtvidiwr

MVWEQGAMVIVMITRCMERGRVKCRRYWPE-DGDCDDHVDLRVQHVETQEYEDHV-ERIFTIDHVQTGQSRTIIHFQMTSWPDFGVPSSAESCLHILGLV
|| .... .|||.   .| |. || .|.|| .|.     .. |   | .. ....  ..... ....|..  . |... ||||  |. |. . | .|  .
mvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlril

RQAqasavlamgpswkghpSGpPIVVHCSAGIGRTGTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLE
|.|                || |.|||||||||||||| .... .  | .    .....|. ||  |.  .|   ||     ..|.
rka................sG.pvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_CG7180_pd Subfamily CG7180 350-599 2e-48 159.6 In-house 41-291 (296) alignment 
Range on Protein: 350-599
Range on HMM: 41-291/296.0
ANLRKNRYTDVLCVEETRVPLSPVDEDDCSDYIHANFTDGYRQHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITRCMERGRvKCRRYWPEDGdCDDH
 |. |||. .|.  . .|| |. .| .. |||| | . |.. ..|..| |..|  .|  .|||.|.....  .|..|. ..  . ..  |||...   ..
enreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks.keqy

VDLRVQHVETQEYEDHVERIFTIDHV----------QTGQSRTIIHFQMTSWPD-FGVPSSAESCLHILGLVRQAQASAvlamgpswKGHPSGPPIVVHC
 .. |. ||...| . . | | . .            . . |.. .||.| |.    ||.|... ....  ||. .  .        . .|   |.||..
geifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekv........dedpeegPvvvvs

SAGIGRTGTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEFAL
| | .|.| ....|.|.  ...|.  .. . || || .| ..... |.| ..   .||. |
sdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl
0036282 (Phosphotyrosine protein) phosphatases II 379-591 3.4e-48 158.9 In-house 2-163 (174) alignment 
Range on Protein: 379-591
Range on HMM: 2-163/174.0
SDYIHANFTDGYRQHKAFIATQGPLPnttsdFWRMVWEQGAMVIVMITRCMERGRVKCRRYWPEdgdcddhvdlrvqhvetqeyedhveriftidhVQTG
||||.|.. |...  . .||.||||.     ||.|..|.|  ..|| ....|.|..|| .||||                                 .. 
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lred

QSRTIIHFQMTSWPDFGVPSSAEsCLHILGLVRQAQasavlamgpswkGHPSGPPIVVHCSAGIGRTGTFCTLDINVSRLQhEGVCEIVNTVKYLRTQRA
 .|..|... . |||.|||....  |... .|..|.             ...| |..||||||.|||||.. ...   .|  |.. .....|. ||.|| 
lerlgiqylylpwpDhgvpdlsi.llefvkfveeal............sedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrp

HMIQTPEQYEFCH
.|.|||.||.|..
gmvqtpsQyrfly
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 326-600 2.8e-46 152.9 In-house 17-279 (307) alignment 
Range on Protein: 326-600
Range on HMM: 17-279/307.0
GIRRQYLELRNMPVEGTFLrTKLRANLRKNRYTDVLCVEETRVPLSpvDEDDCSDYIHANFTDGYRQHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMI
 .. .. .| ..  ||      ..||  ||||.|| |.. .|. .    .  .|||||||.     . | ||..|||| ||  .|| |. ..    ..|.
alvdefrvlakktpegvtv.eafsantdknryqdvkcqdkgrivvk..fdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesviml

TRCMERGRVKCRRYWPE-DGDCDDH------VDLRVQHVETQEYEDHVERIFTIDHVQTGQSRTIIHFQMTSWPDFGVPSSAESCLHILGLVRQAQAsav
 ...| ...||..|||  .|.   .      . .    ...   ....  . |.. . ...|||| |.| . ||| |||    ... .|  ||  .    
ckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydtn...

lamgpswkghpsgpPIVVHCSAGIGRTGTFCTLDINVSRLQH-EGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEFALS
              |.|||||||.||.||  .. .   ..   .   .. . |. ||.|| . |||  || . |  .||. | 
..............pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfle
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 326-594 1.1e-45 150.6 In-house 16-289 (301) alignment 
Range on Protein: 326-594
Range on HMM: 16-289/301.0
GIRRQYLELRNMPVEGTFLRTKlRANLRKNRYTDVLCVEETRVPLSPVDE-DDCS-DYIHANFTDGYRQHKAFIATQGPLPNTTSDFWRMVWEQGAMVIV
..  || ||...  . . . ..  .| . ||. ..  ... |. |.|  . | |. .|| |.. |||...|.|||.|||. .|  ||||..|..  . ||
kfeeqykelkegedksctvgls.eenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsiv

MITRCMERGRVKCRRYWPE-DGDCDDHVDLRVQHVETQEYEDHVERIFTI-----------------DHVQtgQSRTIIHFQMTSWPDFGVPSSAESCLH
|.|   |. . ||..|||. . . .. . . |. |..| | |.| | ...                 .. .  .|.... .|.|.||. ||       |.
mvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprtvLq

ILGLVRQAQASavlamgpswkghPSGPPIVVHCSAGIGRTGTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAV
..  | ..| .            ..| |.|||||....|.|..|...| .   . ||| .... .| .| ..  ...| ||| . . ..
viddvihrqqk............igggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvi
subfamily_ptpA1_pd Subfamily ptpA1 348-560 1.2e-45 151.1 In-house 44-258 (418) alignment 
Range on Protein: 348-560
Range on HMM: 44-258/418.0
LRANLRKNRYTDVLCVEETRVPLSPVDEDDCSDYIHANFTDGYrQHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITRCMERGRVKCRRYWPEDGDCD
 . |  |||||..| |. ||| |  ... . |||| ||. ||    | ||.|||||||| .||||||||. . .|||..|  |  |.|| |||||.   .
kkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidga.ypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigge

DHV-------DLRVQHVETQEYEDHVER-IFT--IDHVQTGQSRTIIHFQMTSWPDFGVPSSAESCLHILGLVRQAQASAVlamgPSWKghpSGPPIVVH
.          .    ||  |  .  || | |  |     |..| | ..|   |||. .|  ..   ..|  . . |   .    ||        ||.||
qfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqii....pssd...rnvpiivh

CSAGIGRTGTFCTLDINVSRLQH
||||.||||||||  | . .|.|
csagvgrtgtfctavimmkkldh
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 351-596 6.5e-45 148.2 In-house 3-237 (237) alignment 
Range on Protein: 351-596
Range on HMM: 3-237/237.0
NLRKNRYTDVLCVEETRVPLSPVDEDdcSDYIHANFTDGYR-QHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITRCMERGRVKCRRYWPEDGDCDDH
|  |||| .. . . .|| |     .  |||| |.. .|.    | .||.|||| ..  |||.|||..   ||||.|  .|. ..|| .|||.  .   .
nkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

VDLRVQHVETQEYEDHVERIFTIDHVQTG-QSRTIIHFQMTSWPDFGVPSSAESCLHIlglvRQAqasaVLAMGPswKGhPSGPPIVVHCSAGIGRTGTF
  | |     .|. |.  | ... . .|  . | |  .|.||||| |||  . . | .    |.     ..   |  .  .   | ..|||||.|||| |
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrf....rkn....iinrsp..hv.sesgpwiihcsagvgrtgif

CTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLE
  .|  . . . . | .| | |. .  .| ..||| .|| | | ..||
lvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
0043147 (Phosphotyrosine protein) phosphatases II 376-591 5.7e-44 145.2 In-house 2-154 (172) alignment 
Range on Protein: 376-591
Range on HMM: 2-154/172.0
DDCSDYIHANFTDGYRQHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITRCmergrvkcrrywpedgdcddhvdlrvqhvetqeyedhveriftiDHV
|. ||||.|.. |.|.  . ||||||||.||..|||||..|.|  .||..|..                                             . 
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel............................................lyd

QTGQSRTIIHFQMTSWPDFGVPsSAESCLHILGLVRQ--AQASavlamgpswkghpsGPPIVVHCSAGIGRTGTFCTLDINVsrlqhEGVcEIVNTVKYL
 .. .|..|... ..|||.||| ..|  |..| ....  |. .              | |..||||||.|||||.. ...       .|.  . ..|...
pellerlgiqylylpwpDhgvp.llellleflefidellalsp..............ggpvlVHCsaGvgRtgtlvaaylml.....lgl.sleeavalv

RTQRAHMIQTPEQYEFCH
|..| ...|.|.|| |..
rekRpgavqnpsqyrfly
0046846 (Phosphotyrosine protein) phosphatases II 372-597 8.8e-44 144.7 In-house 5-172 (176) alignment 
Range on Protein: 372-597
Range on HMM: 5-172/176.0
PVDEDDCSDYIHANFTDGYRqhkaFIATQGPLPNTTSDFWRMVWEQGAMVIVMITRCMERGRVKCRRYWPEDGDCDDhvdlrvqhvetqeyedhverift
.  .| ..|||.||. .|.|    .||||||||.|. ||..|..|.|  ..|..| ..| ||.|| .||||  . .                        
llgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.......................

idhvqtgqsrtiiHFQMTSWPDFGVPSSaESCLHILGLVRQAQasavlamgpswkghPSGPPIVVHCSAGIGRTGTFCTLDinvsRLQHEGVCEIVNTVK
             ... . |||.|||.. | .|..| ..|.|.               .| |..||||||||||||.. ..     |..|    . ....
.............qylhlpwpDhgvpdl.elllellefireal..............keggpvlVHCsaGigRtgtlvaay....llelekglsveeala

YLRTQRA-HMIQTPEQYEFCHLAVLEF
..| ||  ...||||||.|.. ..|..
lvreqRplgavqtpeQyrflyefelll
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 347-598 5.8e-41 135.2 In-house 41-236 (392) alignment 
Range on Protein: 347-598
Range on HMM: 41-236/392.0
KLRANLRKNRYTDVLCVEETRVPLSPVDEDDCSDYIHANFTDGYRQHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITRCMERGrvkcrrywpedgdc
.   ||.|||| ..|  ...|| |  .|.   |||. | . ... ..||.||.||| . . .||||||... .  |.|.|.  |                
qkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd..............

ddhvdlrvqhvetqeyedhveriftidhvQTGQSRTIIHFQMTSWPDFGVPSSAESCLHILGLVrqaQASavlaMGpSWkGHpsgpPIVVHCSAGIGRTG
                             .  . ||.  |..| ||| .||  . | |...  |   .|      | ..  |    |...|||||.||||
.............................kgddartvaqfhftewPdkdvpkhtssllkfikev...kad....fG.qy.th....pliihcsagvgrtg

TFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEFA
   ..|  |.. ..  . ...| |  .| .| .|.|| ||| | . ||||  
vvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 351-599 5.4e-40 131.9 In-house 55-290 (305) alignment 
Range on Protein: 351-599
Range on HMM: 55-290/305.0
NLRKNRYTDVLCVEETRVPlspVDEDDCSDYIHANFTDG-YRQHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITRCMERGRVKCRRYWPEDGDCDDH
.  ||||.|| | ... |    .|.   |||||||.       .| ||..|||| .|  .|| || ..    |||. . .| |..|| .|||       .
aitknryqdvpcqdqsavk...ldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

V--DLRVQHVET-QEYEDHVERIFTIDHVQT--GQSRTIIHFQMTSWPDFGVPSSAESCLHILGLVRQAQAsavlamgpswkghpsgpPIVVHCSAGIGR
.   . |. |   .  |   |   |. ..    .|. .. |.| | ||| |||    . | .|  .| ..                  ||||||||||||
lksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgskv.................pivvhcsagigr

TGTFCTLDINVSRLQHEGVCE-IVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEFAL
|||  ...  . ..  .  |  . . || || |||. ||.  || | |  .|.. |
tgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl
0049260 (Phosphotyrosine protein) phosphatases II 387-591 1e-39 131.0 In-house 2-143 (152) alignment 
Range on Protein: 387-591
Range on HMM: 2-143/152.0
TDGYRQHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITRCMERGRVKCRRYWpedgdcddhvdlrvqhvetqeyedhveriftidhvqtgqsrtiiHF
 |||.....|||||||.|||..|||||..|.|. .|||.|...|.|..|| .|.                                            ..
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................qy

QMTSWPDFGVPSSAESCLHILGLVRQAqasaV-LamgpswkghpSGPPIVVHCSAGIGRTGTFCTLDINVsrlqheGVCEIVNTVKYLRTQRAHMIQTPE
. . |||.|||....  | .| .....                 .| |..||||||.|||||.. ...          ... ..|...|..| .....|.
lhlpwpDhgvpdlsqlllflllfiekl....ald..........kggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpg

QYEFCH
|..|..
qlrfly
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 351-598 7.6e-39 128.3 In-house 33-259 (267) alignment 
Range on Protein: 351-598
Range on HMM: 33-259/267.0
NLRKNRYTDVLCVEETRVPLSPVDEDdcsdYIHANFTDGYRQHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITRCMErgrVKCRRYWPED-GDCDDH
|  .||. |.|  ..|||.|.  .|.    || | . .||.. .|||.||.|| || .||. .. .|.  |||..|.  .    . |..||   |..  .
nqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvft...dnirlfwPPkmgqakky

VDLRVQHVETQEYEDHveRIFTIDHVQTGQS-RTIIHFQMTSWpdfGVPSSAESCLHI-LGLVRQAQasavLAMGpswkghpsGPPIVVHCSAGIGRTGT
 || |.|   .| .|.  .| |..     .| . .  .    |    . .  .  |.  .|.. . |    |  |        ..|.||.||.|.||.||
qdltvehslekeendy..qiitlelkfknesahnvtlyyykkw...nintnnkpylkplfgilaknq....leng........nrPlvvacsdGvGrsGt

FCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEFA
| ..|  . |...||| .| . .. .| ||  ...| |.| ..|  . |.|
flvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeya
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 350-604 9.2e-39 127.8 In-house 36-275 (281) alignment 
Range on Protein: 350-604
Range on HMM: 36-275/281.0
ANLRKNRYTDVLCVEETRVPLSP-VDEDDCSDYIHANFTDGYRQHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITRCMERGRVKCRRYWPEDGDCDD
 | .||||... |.. .|| |   . . . .||||||.      .. .| ||||  .| .|||||.|.. .  |||. . .|  | ||  |.| .  |  
vnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahccl

HVDL-RVQHVETQEYEDHVEriFTIDHVQTGQSRTIIHFQMTSWPDFGVPSSAESCLHILGLVRqaqASavlamgpswkghpSGPPiVVHCSAGIGRTGT
..|   |.. ..   .  |     ..    |..| | |.    |||. || |.|  |.||  .|   |              | || |.|||||.||.||
qfdklsvsyedstvnkslvt..trlnlsyegetrlithwlwkewpdwqvpessevmlkilrkir...ar.............stpp.vihcsagvgrsgt

FCTLDINVSRL-QHEGVCEIVNTVKYLR-TQRAHMIQTPEQYEFCHLAVLEFALSLPSI
. ...| .  .  |  . .| . | .|| | ||  .|| .|| .    .|.| ..   |
lmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgvaykqi
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 314-599 1.1e-38 127.5 In-house 16-291 (310) alignment 
Range on Protein: 314-599
Range on HMM: 16-291/310.0
EFLAHVKGLGRRGIRRQYLELRNMpVEGTFLRTKLRANLRKNRYTDVLCVEETRVPLSpVDEDDCSDYIHANFTDGYRQHKAFIATQGPLPNTTSDFWRM
.|.   . ||  |. .||  |     . ..     . .. ||||.||.| ...|| |  .|     ||||||.       ..|| .||||  |  |||||
nfiiateklgieglvkqyrkldak.qdssltyeaykkymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrm

VWEQGAMVIVMITRCMERGRVKCRRYWPEDGDCDDHVDLRVQHVET--QEYED-HVERIFTIDHVQTGQSRT------IIHFQMTSWPDFGVPSsaESCl
.... |  |... . .| || ||  |||  |  . .  .||  .    .|.|   .   |  | |   .  .      .   .   ||| |||   | | 
ifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpd..ekc.

HIlglVRQAQASAVlAmgpswkgHpsGpPIVVHCSAGIGRTGTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEFAL
|    | |   . |         |  | | |||||||..|... ..|.... .|..    .. . .  |. .||  |||. || . .   . || 
ht...vpqrllaqv.r.......h..g.pcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifar
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 312-602 3.9e-37 122.6 In-house 9-291 (305) alignment 
Range on Protein: 312-602
Range on HMM: 9-291/305.0
IMEFLAHVKGLGRRGIRRQYLELRNMPVEGTFLRTKLRANLRKNRYTDVLCVEETRVPLSPVdedDCSDYIHANFTDGYRQHKAFIATQGPLPNTTSDFW
|..|. ..   | .|.| ..  .. .     .   |   .  |||| || |... || | .       .|||||.     . | || || || .| .|||
ilkfvkrtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvklegp...wpheyihanyvstptnpkrfictqaplektcadfw

RMVWEQGAMVIVMITRCMERGRVKCRRYWPED-GD------CDDHVDLRVQHVETQEYEDHVERI-----FTIDhVQTGQSRTIIHFQMTSWPDFGVPSS
 | ...    | |.   .|.|  ||  |.. . .|       .... ....  .| ..... .       ..|.    ...| . |.    ||| |||..
ymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlvie.gpgekarkvthyhwidwpdrgvpaa

AESclhILGLVRQAQASavlamgpswKGhpsgpPIVVHCSAGIGRTGTFCTLDINVSRLQHEGVCE-IVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEFA
  .   || |. .|..|         ||     ||||||||||||||.   |.  . .|    . |     .. .| ||   ||| .|| | |  .|.. 
dla...ilellekarps.........kg.....pivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf

LSLP
.   
rkkk
0051082 (Phosphotyrosine protein) phosphatases II 379-595 1.5e-35 117.4 In-house 3-150 (151) alignment 
Range on Protein: 379-595
Range on HMM: 3-150/151.0
SDYIHANFTDGYrqhkaFIATQGPLPnttsDFWRMVWEQGAMVIVMITRCMERGrvKCRRYWPEDGdcddhvdlrvqhvetqeyedhveriftidhvqtg
||||.... .|.     .....|||.    ||.....|.|  .||...  .|||  .| .|.|| |                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

qsRTIIHFQMTSWPDFGVPSSAESCLHILGLVRQaqasavlamgpswkghPSGPPIVVHCSAGIGRTGTFCTLDINVSRlqhegvCEIVNTVKYLRTQRA
  ....|.....|||.|.| | ...|..| |...                ... |..||||||.|||||.. |..   .      . .  .....| .| 
..ievlhipildwpdpglplsfdavleflellld................kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrp

HMIQTPEQYEFCHLAVL
...|...|. |...|.|
gvvqpnqqflfqlfall
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 316-597 3.7e-35 116.4 In-house 10-270 (288) alignment 
Range on Protein: 316-597
Range on HMM: 10-270/288.0
LAHVKGLGRRGIRRQYLELRNMPVEGtfLRTKLRANLRKNRYTDVLCVEETRVPLSpvdeDDCSDYIHANFTDGYRQHKAFIATQGPLPNTTSDFWRMVW
. .|   .  |. ..| .  |   .     ..  ||  ..||... . . ||| ||    ||.  ||.||     . .. .| .| ||  |   .|.|. 
irlvlqiaveglkkeyrdspneasid..iidsfianptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmll

EQGAMVIVMITRCMERGRVKCRRYWPEDGDcdDHVDLRVQHVETQEYEDHVERIFTID---HVQTGQSRT-IIHFQMTSWPDFGVPSSAESCLHILGLVr
|..   |||... .|.|. |   |.|      ... ..     ...  . .... ..      ..|. .  . .  .  |.| ||| .  | |..|  . 
esdveyivmlcellekGkeksaeyfPsklG..ekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.

qaqasavlamgpswK---GhpsgpPIVVHCSAGIGRTGTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEF
              |         |||||.|||.|||||.    | .  |. .    | . .. || .| . |||  || . |  ||| 
..............kslqk.....PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvlee
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 353-591 1.4e-33 111.0 In-house 52-274 (301) alignment 
Range on Protein: 353-591
Range on HMM: 52-274/301.0
RKNRYTDVLCVEETRVPlspVDEDDCSDYIHANFTDGYRQHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITRCMERGRVKCRRYWPEDGDcdDHVDL
 |.||  | |  .| |    | .|     ||||. .   . . ||||||||.||. ||| |.       |||... .|.   ||. | | .    ...|.
dkhryptvPckPstave...vivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkis..ekldi

RVQHVETQEY-----EDHVERIFTI-DHVQTGQSRTIIHFQMTSWPDFGVPSSAESCLHILGLVRQAQAsavlamgpswkghpsgpPIVVHCSAGIGRTG
   ......      .. ..| . . |  .  ..||..|.| ..|.| ||| |   . ... ||....                  ||||||||||||. 
grfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksek.................PivvhcsaGiGrsv

TFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCH
.| . ..  .... .   |. ...| || .| . .|| .|  .  
afigteylareveadptieltealkhlrehrwngvqtnsqlywmt
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 337-599 1.5e-33 111.0 In-house 23-271 (285) alignment 
Range on Protein: 337-599
Range on HMM: 23-271/285.0
MPVEGTFlrTKLRANLRKNRYTDVLCVEETRVPLSPVDeddcSDYIHANFTDG-YRQHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITRCMERGRVK
|| . |.  |   ||   |||.|| |.||||| |   |     |||||..     ... ..|.||||||.| ||||.|....    ..|.   .| |  |
mppncty..tayeanpdlnryadvrcieetrvvlknhd....rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvek

CRRYWPED-GDCDDHVDLRVQHVETQEYE--DHVERIFTIDHVQTGQSR--TIIHFQMTSWPDFGVPSSAESCLHILGLVRqaqasavlamgpswKGHPS
|  |.||  |.        .   | .|      .   .|.   .   |    . | |.  |||   |  |   . .   |.              |  | 
calyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvk..............kvnpk

GPPIVVHCSAGIGRTGTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEFAL
  ||.||||||.||| ||  .|    |.  .   |... |. .|. | . .|.  |. | .. ..|. .
ekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfi
PTPc_DSPc_SM00012 483-596 2e-33 110.1 In-house 2-105 (105) alignment 
Range on Protein: 483-596
Range on HMM: 2-105/105.0
IIHFQMTSWPDFGVPSSAESCLHILGLVRQAQASAVLamgpswkghpsGPPIVVHCSAGIGRTGTFCTLDINVSRLQHE-GVCEIVNTVKYLRTQRAHMI
. |...|.|||.|||....| |..|  |.. .  .             ..|.|||||||.||||||..||| ...|..| .  .| ..||.||.||..|.
vkhyhytgwpdhgvPeesdsilellravkknknkses...........skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmv

QTPEQYEFCHLAVLE
|| ||| |.. |.||
qteeqylflyralle
0044763 (Phosphotyrosine protein) phosphatases II 363-593 1.9e-32 107.7 In-house 2-166 (178) alignment 
Range on Protein: 363-593
Range on HMM: 2-166/178.0
VEETRVPLSPVDEDDCSDYIHANFTDGYrqhkAFIATQGPlpnttSDFWRMVWEQGAMVIVMITRCMERGRVKCRRYWPEDGDcddhvdlrvqhvetqey
...||| ||..    .||||.|.. ...     ......|     .|......|.|  .||..|  .|.|..|| .||||. .                 
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

edhveriftidhvqtgqsrtiIHFQMTSWPDFGVPSSAESCLHILGLVRQAQasavlamgpswkgHPSGPPIVVHCSAGIGRTGTFCTLDINVSRlqheG
                     |... . .||.|||.. | .| .. ....|.             ...| |..||||||.||.||.. ...  ..    |
.....................iqylhipipDhgvpdllehflefvefieeal.............dekggpvlVHCsaGvgRsgtlvaaylmkkl....g

VcEIVNTVKYLRTQRAhMIQTPEQYEFCHLA
.  . . ....| .|  ....|.|...... 
l.sleeaielvrerRp.ivpnpgqlrqLyef
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 354-605 4.1e-32 106.1 In-house 46-283 (312) alignment 
Range on Protein: 354-605
Range on HMM: 46-283/312.0
KNRYTDVLCVEETRVPLSpvdeDDCSDYIHANFTDGYRQHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITRCMERGRVKCRRYWPEDGDCDDHVDLR
 ||| .. | .  |  |.     |   ||||||     . . |..||||| ||.. ||...   |.  |....  .| |  || .|  .     |  | |
lnrypniqcwdrgrftla....gdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhr

VQHVETQEYE-------DHVERIFTIDHVQTGQSRTIIHFQMTSWPDFGVPSSAESCLHILGLVRQAQAsavlamgpswkghpsgpPIVVHCSAGIGRTG
|      | |           |.. .    |||   . |.| .|||| |.| | ...| .|  |.. .                  |.. |||||.||||
vyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk.................pviahcsagvgrtg

TFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEFALSLPSIN
|.. ..  .. |.|    .. ..   || .||  ...  || ..  .||||  |    .
tlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglyk
subfamily_egg_pd Subfamily egg 332-597 1.7e-29 97.5 In-house 20-269 (307) alignment 
Range on Protein: 332-597
Range on HMM: 20-269/307.0
LELRNMPVEGTFLRTKL-RANLRKNRYTDVLCVEETRVPLSPVDEDDCSDYIHANFTDGYRQHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITRCME
||. .  |.   |.| .   || | |   | | . .|| |         |.||||  .|      || .| || ||  ||||||...    |||.|   |
levleesvdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrke

RgrVKCRRYWPEDGDCDDHVDLRVQHVETQEYEDHVERIFTIDHVQ-TGQSRTIIHFQMTSWpDFGVPSSAESCLHILGLVRQAQAsavlamgpswkghp
    .|  |||   .    .     ..|. . ... . .|.. ...  |  .   . .   . |.   |   | |..| ..|..                
s..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqg.dvnnssdvysplrvlrklrnlsk..............

sgpPIVVHCSAGIGRTGTFCTLDINVSRLQHEGVC--EIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEF
   |.||..  |. ...|. ...| .  |    .    . ..|..|| .|   .... .| | .  || |
...pvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlff
subfamily_CG42327_pd Subfamily CG42327 353-515 2.1e-29 97.2 In-house 30-195 (319) alignment 
Range on Protein: 353-515
Range on HMM: 30-195/319.0
RKNRYTDVLCVEETRVPLSPVDEDDCSDYIHANFTDGYRQ-HKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITRCMERGRVKCRRYWPEDGDCDDHV-
 |.|. .|. . |||| |  . .|| . |..|..  ||.. .  .||.| .| ...|||||.|||| . ||| .|   | |  .| .|.|     |..  
dksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntsl

--DLRVQHVETQEYEDHVERIFTIDHVQTGQSRTIIHFQMtSWPDFGVPSSAESCLHILGLVRQAQA
  |..|   . .  . ..   . . .|.  .|| . |.    |.. .||.. .. . .|  ||..  
yGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrsslk
0048076 (Phosphotyrosine protein) phosphatases II 463-595 1.2e-26 88.5 In-house 27-140 (145) alignment 
Range on Protein: 463-595
Range on HMM: 27-140/145.0
EDHVERIFTIDHVQTGQSRTIIHFQMTSWPDFGVPSSAESCLHILGLVRQAQASavlamgpswkghpsGPPIVVHCSAGIGRTGTFCTLDINVSrlqhEG
. .. ..... . ... .|..|... ..|||.|||...|  |..| ....|...              | |..||||||.|||||.. ...  .    .|
dlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke..............ggpvlVHCsaGvgRtgtlvaaylmll....lg

vCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVL
 . . ......|.|| .....|.|..|.....|
.vsleealelvrsqrpgavpnpgqlrflyefel
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 347-599 1.2e-24 81.5 In-house 43-280 (303) alignment 
Range on Protein: 347-599
Range on HMM: 43-280/303.0
KLRANLRKNRYTDVLCVEETRVPLSpvdedDcSDYIHANFTDGYRQHKAfIATQGPLPNTTSDFWRMVWEQGAMVIVMITRCMERGRVKCRRYWPEDGDC
..  |. |||..||.|.. ..| ||     | | ||||.. .   ..|| | || ||. |..|||.|. ||   .....    |  ..     .|.. | 
qfvknmdknrfvdvicldhskvkls.....d.ssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdf

DDHVDLRVQHVETQEYEDHVERIFTIDHVQTGQSRTIIHFQ-MTSWPDFGVPSSAESclHILGLVRQAQasAVLAmgpswKGHPSGPPIVVHcSAGIGRT
 .  .  ..  | .. |      . .  |  |. ....| .   .||   .|| . .  ...  . | |  .||      |  .| |.. .   .| ||.
lkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgsp..kfvkqiwqlq..svlr.....kysdstptvyms.lsgcgra

GTFCTLDINVSRLQHE-GVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEFAL
|||. ..     |. |    ..|. .. .|  | | .|   |. . .  . |  |
gtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvl
CRAL_TRIO CRAL/TRIO domain 124-238 1.3e-24 75.2 Pfam-A 36-159 (159) alignment 
Range on Protein: 124-238
Range on HMM: 36-159/159.0
SNKVLTGMVFQLEQAI-KSPL-TQRSGLVLLYDMSNSSYKNFD---FDLSQKILELLKGGYPARLKSVFIISPPLWFKAVLLILSSFLREKIRERIEILS
.....  ....||... . .  .|. |.....||.. |.....   ..| .|||..|.  || ||. ..|. .| .||... ....|| ||.||.| ..|
eeelvrllllvlerllklleedgqiegvtvviDmkglslskmlwkpisllkkilkilqdnyperlgkilivnaPklfkvafklvkpfldektreKikfvs

I----EQLQDRLPIGTIPKSLGGK
     ..|..  .   .||.|||.
psntpatlekyidpeqlpkelGGt
0048179 (Phosphotyrosine protein) phosphatases II 474-592 1.9e-24 81.4 In-house 48-139 (144) alignment 
Range on Protein: 474-592
Range on HMM: 48-139/144.0
HvqtgqsrtIIHFQMTSWPDFGVPSSAESCLHILGLVRQAqasavlamgpswkgHPSGPPIVVHCSAGIGRTGTFCTLDINVsrlqHEGvCEIVNTVKYL
.        .|... ..|||.|||...| .|..| ....|              ...| |..||||||.|||||...... .    ..| . . ......
e........giqylhlpwpDhgvpdllellleflefieea..............leeggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalv

RTQRAHMIQTPEQYEFCHL
|..| .....|.|..|...
rsrrpgavpnpgqlrfLle
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 393-590 1.2e-21 71.8 In-house 4-196 (199) alignment 
Range on Protein: 393-590
Range on HMM: 4-196/199.0
HKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITRCMERGRVKCRRYWPEDGDCDD---HVDLRVQHVETQEYEDHVERIFTIDHVQTGQSRTIIHFQMT
.. .|||| || .| .|||.|||| |.  |||.        .    |||           . . .. . |.     .  |.| .      .| | |.|.|
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

SWPDFGVPSSAescLhILGLVRqaqASAVLAmgPSWKgHPSGPPIVVHCSAGIGRTGTFCTLDINVSRLQ--HEGVCEIVNTVKYLRTQRAHMIQTPEQY
|| .   |  |   | ..|.|    ||  ..    ..      |..|||| | | || | .||| |   .  .  | .. .  | ||  |  .| . ..|
swkekttpnva...l.fvgfvv...asrevs..kkye.qekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhy

EFC
.| 
nfi
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 393-590 1.4e-21 71.6 In-house 3-195 (198) alignment 
Range on Protein: 393-590
Range on HMM: 3-195/198.0
HKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITRCMERGRVKCRRYWPEDGDCDD---HVDLRVQHVETQEYEDHVERIFTIDHVQTGQSRTIIHFQMT
.. .|||| || .| .|||.|||| |.  |||.        .    |||           . . .. . |.     .  |.| .      .| | |.|.|
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

SWPDFGVPSSAescLhILGLVRqaqASAVLAmgPSWKgHPSGPPIVVHCSAGIGRTGTFCTLDINVSRLQ--HEGVCEIVNTVKYLRTQRAHMIQTPEQY
|| .   |  |   | ..|.|    ||  ..    ..      |..|||| | | || | .||| |   .  .  | .. .  | ||  |  .| . ..|
swkekttpnva...l.fvgfvv...asrevs..kkye.qekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhy

EFC
.| 
nfi
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 353-472 2.5e-21 70.8 In-house 49-182 (350) alignment 
Range on Protein: 353-472
Range on HMM: 49-182/350.0
RKNRYTDVLCVEETRVPLS----PVD----EDDCSDYIHANFTD----GYRQHKAF--IATQGPLPNTTSDFWRMVWEQGAMVIVMITRCMERGRVKCRR
 ||||...|  | .|| |     . |        .||| ||.      . ..   |  ||||.|||.|  ||.... . .  ||...|  .| .. || |
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPEDGDCDDHVDLRVQHVETQEYEDHVERIFTI
||.| .  | .| |  .. .. . .| . . . .
YWqegsydditvklaskwenimgindsslysadv
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 319-599 6.9e-20 65.7 In-house 20-286 (302) alignment 
Range on Protein: 319-599
Range on HMM: 20-286/302.0
VKGLGRRGIRRQYLELRNMPVEGTFlRTKLRANLRKNRYTDVLCVEETRVPLSpvdeDDCSDYIHANFTDGYRQHKAFIATQGPLPNTT---SDFWRMVW
|| |    ..... .. .| |.     .  ..||.||. .|| ......| |.        .|..|  ..    ..  | .| |  ...    .|||||.
vksldtaevkkefkkidtmkvdlek.Ckafkknlkknqsedvpildsnlvkle....aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvf

EQGAMVIVMITRCMERGRvKCRRYWP-EDGDCDDHVDLRVQHVETQEYEDHVeRIFTIDHVQTGQSRTIIH--FQMTSWPDFGVPSSAESclhilgLVRQ
..    .|.. .  |  .     ..| . ||  .. ...|     .. |...   ..|. .  | | ...     .| |..  || .  .      |...
qekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyae......likt

aqASAVlamgpSWKGHPSGPPIVVHCSAGIGRTGTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEFAL
  |  |       |  ..  ..|.    |.|| |.| || . |..||..   .| ..|| .|.||...... .|| . ..|.| . .
..aakv.....fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyik
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 473-609 6.3e-17 56.0 In-house 81-205 (440) alignment 
Range on Protein: 473-609
Range on HMM: 81-205/440.0
DHVQTGQSRTIIHFQMTSWPDFGVPSSAESCLHILGLVRQAQASAvlamgpswkGhpSGpPIVVHCSAGIGRTGTFCTLDINVSRLQHEGVCEIVNTVKY
 ...  .|||. .... .||| |||  |   |...  | ..|  |         |  .| |..|||||| ||||   ..|  .   ..    .|.. .. 
syingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqeka.........g..ng.pllvhcsagagrtgviiavdsilreakrsdqidifsfins

LRTQRAHMIQTPEQYEFCHLAVLEFALSLPSINGEDK
.| .| .|.|||||| | | ||||  |.  ..  || 
mrnnrpqmvqtpeqyafvheavlegllcgdtliledd
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 483-597 2.9e-16 54.1 In-house 217-343 (350) alignment 
Range on Protein: 483-597
Range on HMM: 217-343/350.0
IIHFQMTSWPDFGVPSSAESCLHILGlVRQAQASAVLAMgpSWKGHPSGPPIVVHCSAGIGRTGTFCTLDINVS------RLQHEG---------VCEIV
. ..|.  |.| ..    || |..|  |..       |   |.     ..||.||||||.|||||..|||  .|       |..|             | 
vyqlqvknWkDlslllnPesilqale.vkndliddlfae..shldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlis

NTVKYLRTQRAHMIQTPEQYEFCHLAVLEF
 .|. || ||  |.|. .|. |.. |.| .
iivnelrkqrismvqnldqfifiYeallfy
subfamily_CG42327_pd Subfamily CG42327 532-599 3e-16 54.0 In-house 248-316 (319) alignment 
Range on Protein: 532-599
Range on HMM: 248-316/319.0
PPIVVHCSAGIGRTGTFCTLDINVSRLQHE-GVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEFAL
 |.||||| |.||||.  . ||.. .|..     .| ..| ..| .||. ..| ||||| .  . |.| 
GPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 534-596 1.2e-14 48.4 In-house 1-63 (69) alignment 
Range on Protein: 534-596
Range on HMM: 1-63/69.0
IVVHCSAGIGRTGTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLE
.|||||.| |||||| .. ....|.. | . .| | |.|.|  |  |.    .| | | |. |
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalve
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 535-600 1.5e-14 48.1 In-house 1-65 (69) alignment 
Range on Protein: 535-600
Range on HMM: 1-65/69.0
VVHCSAGIGRTGTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEfALS
|||||.| |||||| .. ....|.. | . .| | |.|.|  |  |.   ..| | | |. | || 
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalve.alk
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 354-518 8.1e-14 46.4 In-house 22-195 (290) alignment 
Range on Protein: 354-518
Range on HMM: 22-195/290.0
KNRYtDVLCVEETRVPLSPVDEDDCSDYIHANFTDgYRQHKAFIATQGPLPNT-------TSDFWRMVWEQGAMVIVMITRCMERGRV----KCRRYWPE
..|. .|  ||.|||.|    .   .||||||.   . .  ..|.|| |. ..         .|| |. .  .  .||.   .|. .      | .| ||
dqRl.evpLveatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpe

DGDCDD-HVDLRVQHVETQEYEDHVERIFTIDHvQTGQSRTIIHFQMTSWPDFGVPSSAESCLHILGLVRQAQASAV
  . .    .| |.  .  . .|  .|  .. . . ..  |. | .. .| .  |. .  . |...  |.. .. ..
svgeelkfkgltvkCkskekeddvetRelvvkf.ddeeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvi
subfamily_eak_pd Subfamily eak 351-600 3.6e-13 43.6 In-house 52-307 (332) alignment 
Range on Protein: 351-600
Range on HMM: 52-307/332.0
NLRKNrYTDVLCVEETRVPLSPVDEDdCSDYIHANFTDGYRQHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITRCMERGRVKCRRYWPEDGdcDDHV
....|   ...  .   | |..   .    || |  ..     . .| |  .  .    ||.|| || .  ||..   .| .  |  .|.|...   . .
avnrn.vvkivpydrylvrltssqln.rlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdkt..reel

DLRVQHVETQEYEDH---VERIFTidhVQTG-QSRTIIHFQMTSWPDFGVPSSAEsCLHILGLVRQAQASAV---------LAMGPSWKGHPSGPPIvVH
.  . .||..|.  .     | .    .. | ..  . |...  | .. .|   .  | .   .... .  .           .    .  ||  || . 
kfGildverkefvkrniletrlle...lskGnethrvlhykvfGwtettlpkyed.flalrkvmkevGvlllivmksallsstlkkyihtppsfapi.iq

CSAGIGRTGTFCTLDINVSRL--QHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEFALS
.. |  |.|.|  .|. .  .  . . .  . . .   ...| | . .  |. | . .||.. | 
sarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllr
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 366-517 4.1e-13 44.0 In-house 9-152 (255) alignment 
Range on Protein: 366-517
Range on HMM: 9-152/255.0
TRVPLSPVDEDDCSDYIHANFTDGYRQHKAFiatqgplpnTTSDFWRMVWEQGAMVIVMITRCMERGRVKCRRYWPEDGDCDDHVDlRVQHVETQEYEDH
...| . .||| |.. .. .     ..  ..         |   |....  ... |.||..   | |..|| .|.| . |    .   |. . |.   | 
kklPrilidedvctehvkPekdkkrknlysl.........tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkla.dvnvtttkssadv

VERIFTIDHVQT--GQSRTIIHFQMTSWPDFGVPSSAESCLHILGLVRQAQASA
| |  .|    .   . .|. |.. . |..   |  |.  |.|| .||....  
vlrtleitstlgekkkthtvkhysykGWieknaPelareilnilkvvrdsksvv
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 354-472 1.3e-12 41.8 In-house 51-185 (349) alignment 
Range on Protein: 354-472
Range on HMM: 51-185/349.0
KNRYTDVLCVEETRVPLS------------PVDEDD--CSDYIHANFTDG--YRQHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITRCMERGRVKCR
|||| |.|  | .|| |               . |     ||| ||.     .  .| .|||| ||| |  ||....  .|  ... ..   | .  || 
knrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcd

RYWPEDGDCDDHVDLRVQHVETQEYEDHVERIFTI
.|| |    . .| |.     . . .  . |..| 
iywqelsysnitvklqnsslyianvqGnslrvstv
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 400-593 5.1e-12 39.9 In-house 97-283 (302) alignment 
Range on Protein: 400-593
Range on HMM: 97-283/302.0
QGPLPNTTSDFWRMVWEQGAMVIVMITRCMERGRVKCRRYWPEDGDCD---DHVDLRVQHVET--QEYEDHV-ERIFTID----HVQTGQSRTIIHFQMT
  |  .|.  .| .. .    ..| ..  .| .  ||  |. .. .      .  ..   |.|  .|. |    ...|..    .... . .|.  .. .
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

SWPDFGVPSSAESCLHILGLVRqaqasavlamgpSWKGHpsgppIVVHCSAGIGRTGTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEF
.||| | |  |.. |.||                |.|       ..||||||.|||||. ..   .   ... |..... |. .|. |   .|. .|  .
awpdhGapkeaytaldilkfce............sykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliy

CHLA
  | 
lllc
subfamily_hpo-7_pd Subfamily hpo-7 366-515 1.2e-11 39.0 In-house 12-156 (263) alignment 
Range on Protein: 366-515
Range on HMM: 12-156/263.0
TRVPLSPVDEDDCSDYIHANFTDGYRQHKAFiatqgpLPNTTSDFWRMVWEQGAMVIVMITRCMERGRVKCRRYWPEDGDCDDHV-DLRVQHVETQEyeD
...| . .||| |.. .. .     ..  ..      | .|   |....  ... |.||..   | |..|| .|.| . |    . .. |   ..|.  |
gklPrilidedvctehfkPekdkkrknlysl......lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..d

HVERIFTIDHV-Q-TGQSRTIIHFQMTSWPDFGVPSSAESCLHILGLVRQAQA
 . .   .  . .   . .|. |.. . |..   |  |.. |.|| ..|. . 
vllktlellstlgeKkkthtvkhysykgWiekndpelareilnilkvarnsks
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 483-597 1.5e-11 38.2 In-house 220-343 (349) alignment 
Range on Protein: 483-597
Range on HMM: 220-343/349.0
IIHFQMTSWPDFGVPSSAESCLHILGlVRQAQASAVLAMgpSWKGHPSGPPIVVHCSAGIGRTGTFCTLDINVS---RLQH---------EGVCEIVNTV
.. .|.  |.| ..     | |. |  |..       |    .      ....|||||| ||||...|||. .|    ||.              |  .|
llqlqvknwldlslllnPisilqale.vkndliddlfar..lyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiiv

KYLRTQRAHMIQTPEQYEFCHLAVLEF
  || ||  |.|   |. ... |.|..
nelrkqrismvqnlaqfiaiyealLky
CRAL_TRIO_2 Divergent CRAL/TRIO domain 143-243 3.2e-11 32.0 Pfam-A 45-148 (149) alignment 
Range on Protein: 143-243
Range on HMM: 45-148/149.0
LTQRSgLVLLYDMSNSS-YKNFDFDLSQKILELLKGGYPARLKSVFIISPPLWFKAVL-LILSSFLREKI-RER-IEILSIEQLQDRLPIGTIPKSLGGK
. ...  || |...  |  ....  .  |....|   |. .|| |... |  ..| .|  .|| |...|  .   | | |...|.. . |  ..|||.| 
ivgkp.yvlVyfhtglssenkpslswlkklyktlprrykknlkkvylvhpstflksilstllslfvskkflkkkviyisslseLseyiditqlkkslpgv

LNVDH
.  |.
ysyde
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 347-427 1.3e-10 35.3 In-house 30-109 (332) alignment 
Range on Protein: 347-427
Range on HMM: 30-109/332.0
KLRANLRKNRYTDVLCVEETRVPLSPVDEDDcsDYIHANFTDGYRQHKAFIATQGPLPNTTS-DFWRMVWEQGAMVIVMITR
|.  |.  ||   . |.. .|| |.| |  |  |.  |.. ||| .. |.| .| |. . |   ||||| |.   .|...  
kflnnmdmnriphlycfdhsrvelapqdgkd..dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgd
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 347-425 3e-10 34.1 In-house 33-116 (347) alignment 
Range on Protein: 347-425
Range on HMM: 33-116/347.0
KLRANLRKNRYTDVLCVEETRVPLSPVD-----EDDCSDYIHANFTDGYRQHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMI
.   .| |||  ||  ...||| ||| .      ||   || |        .| .| || |||.|  |||.||       .| |
ewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 341-505 1.2e-09 31.2 In-house 16-162 (169) alignment 
Range on Protein: 341-505
Range on HMM: 16-162/169.0
GTFLRTKLRANLRKNRYTDVLCVEETRVPLSPVDEDDCSDYIHAnftdgyrqhkafiatqgplpnttsdfwRMVWEQGAMVIVMITRCMERgrvkcRRYW
   . ..| .|  ||| .  |.   ||| |  | ||  |||| |                           ||.||  | |||..  . ..       .|
ynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddk.....nnfw

PEDGDCDDHVDLRV-------QHVETQEYE---DHVERIFTIDHVQTGQSRTIIH----FQMTSWPDFGVPSSAESCLH
||  | . |  . .        .| |.  .     || .| .  |    .... .    .....||. ||| |     |
pekedyqlhpavilGewytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqspvhvgh
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 339-502 1.6e-09 30.9 In-house 15-160 (169) alignment 
Range on Protein: 339-502
Range on HMM: 15-160/169.0
VEGTFLRTKLRANLRKNRYTDVLCVEETRVPLSPVDEDDCSDYIHAnftdgyrqhkafiatqgplpnttsdfwRMVWEQGAMVIVMITRCMERgrvkcRR
.|   . ..| .|  ||| .  |.   ||| |  | ||  |||| |                           ||.||  | |||..  . ..       
ieynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddk.....nn

YWPEDGDCDDHVDLRV-------QHVETQEYE---DHVERIFTIDHVQTGQSRTII----HFQMTSWPDFGVPSSAES
.|||  | . |  . .        .| |.  .   . || .| .  |    ....      .. ..||. ||| |   
fwpekedyqlhpavilgewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqspvh
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 531-595 2.4e-09 31.7 In-house 191-256 (290) alignment 
Range on Protein: 531-595
Range on HMM: 191-256/290.0
GPPIVVHCSAGIGRTGTFCTLDINVSRLQ-HEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVL
. |..|||  || |  .. ....    .   .|  .... .|.|| |||..|...... |   ...
ktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 388-443 1.1e-08 28.9 In-house 230-282 (440) alignment 
Range on Protein: 388-443
Range on HMM: 230-282/440.0
DGYRQHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITRCMERgrvKCRRYWPED
.|| ...|||||| ||  |  ||||.| .     |.|. .  ..    |  ||| .
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvn
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 379-495 2.9e-08 28.1 In-house 13-125 (130) alignment 
Range on Protein: 379-495
Range on HMM: 13-125/130.0
SDYIHANFTDGYRQHKAFIATQGPLPNTTSDFWRMVWEQGAMVIVMITRCMERgrvkcRRYWPEDGDCD-DHVDLRVQHVETQEYEDHVERIFTIDHVQT
 .||.|.|     . . .. || || .|. |||.|. |.   |.|..    |        |||.    .    |. |   . .|..      . |..   
ntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdrdefknikasnleiesdln

GQSRTIIHFQMTSWPDFG
   ...  ||.. ||  |
eshqaltmfqisnwpsdg
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 533-623 4.7e-08 27.4 In-house 150-246 (255) alignment 
Range on Protein: 533-623
Range on HMM: 150-246/255.0
PIVVHCSAGIGRTGTFCTLDINVS----RLQHEG--VCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEFAlsLPSINGEDKQR--IKEFLHAWRSTR
..|||||.||||. .|   ..        |.       . .. .. || .|.  |.|| |  |. | ||..    |  . |.|     | .||| .  .
svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv..fpkgeleakyqeirksylharqmmh
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 348-401 4.9e-08 27.1 In-house 45-95 (95) alignment 
Range on Protein: 348-401
Range on HMM: 45-95/95.0
LRANLRKNRYTDVLCVEETRVPLSPVDEddcSDYIHANFTDGYRQHKAFIATQG
  ||. |||. ...  . ||| |.   .   |||| | | ||| .....||.||
seanipknrflnifpydatrvvlttkrd...sdyinacfvdgyarkncyiaaqg
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 435-599 5e-08 26.8 In-house 149-303 (332) alignment 
Range on Protein: 435-599
Range on HMM: 149-303/332.0
KCRRYWPEDGDCDDHVDLRVQHVEtQEYEDHVeRIFTIDHVQTGQSRTIIHFQMTSWPDFGvpSSAESCLHIlglvrqaQASAVLA-MGPSWKGHPSGPP
 ||..||| .   |   | .|  . .  | |. . | .   .  | .  . ...  | |       |  | .       .||  |  .  | |      |
icrkfwpekrskkdfpalsiqasd.dhsethm.ktfnltvtekkqdhqtvlmhfyewadas..klpeymldm.......rasiklqyirsskktgvcigp

IVVHCSAGIGRTGTFCTLDINVSRLQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEFAL
|.. |..|. .   ..|.|| |||.  |    . .|.  .. ||   ..|   |  .   ...||.
imlvcatgvekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpystacemlmkfav
0038934 (Phosphotyrosine protein) phosphatases II 491-591 2.5e-07 26.0 In-house 87-170 (194) alignment 
Range on Protein: 491-591
Range on HMM: 87-170/194.0
WPDFGVPSSAESCLHILGLVRQAQASAVlamgpswkghpsGPPIVVHCSAGIGRTGTFCTLDInvsrlQHEGVCEIVNTVKYLRTQRAHMIQTPEQYEFC
.||.|.. | |  |..| || .  .               |  ..||| ||.|||||..   .      .   .     ....|  | ..|......|  
fpddgtvPsleillrfldlvdeflnedp............ggvvaVHCkaGlgRtGtlvaaYL.....iyrlgmsaeeAialfrekRpgaipnqdyleal

H
.
l
subfamily_PTPDC1_pd Subfamily PTPDC1 484-591 6.6e-07 23.9 In-house 83-169 (182) alignment 
Range on Protein: 484-591
Range on HMM: 83-169/182.0
IHFQMTSWPDFGVPSsAESCLHILGLVRQAqasaVlAmgpswkghpSGpPIVVHCSAGIGRTGTFCT-LDINVSRLQHEgvceivNTVKYLRTQRAHMIQ
| .   .|.|.||.|  |. | |  .| .|    .            |  . ||| || ||||   .   . ..||. |      ...| .| .|.. ||
iyvynfgwkDygvas.leriLdivkvvafa....l.q.........eg.kvavhChaGlGrtGvliacylvyakrltae......kaiklvrskrpksiq

TPEQYEFCH
| || |...
treqvelvk
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 395-495 2.5e-06 21.3 In-house 138-234 (244) alignment 
Range on Protein: 395-495
Range on HMM: 138-234/244.0
AFIATQGPLPNTTSDFWRMVWEQGAMVIVMITRCMERgrvkcRRYWPEDGDCDD-HVDLRVQHVETQEYEDHVERIFTIDHVQTGQSRTIIHFQMTSWPD
 .| || || .|. |||.|. |.   |.|..    |        |||.    .    |. |   . .|. .     . |.       ...  ||.. || 
eyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwps

FG
 |
dg
subfamily_hpo-7_pd Subfamily hpo-7 533-620 3.4e-06 21.1 In-house 156-252 (263) alignment 
Range on Protein: 533-620
Range on HMM: 156-252/263.0
PIVVHCSAGIGRTGTFCTLDINVS----RLQHEGV--CEIVNTVKYLRTQRAHMIQTPEQYEFCHLAVLEFALSL-PSINGE-DKQRI-KEFLHAWR
..|||||.||||.  |   ..        |.       . .. .. || .|.  |.|| |  |  | ||.| |   .  . |   | | | .||| .
slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfakgeleakyqeirksylharq
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 345-390 4.2e-06 20.6 In-house 33-77 (244) alignment 
Range on Protein: 345-390
Range on HMM: 33-77/244.0
RTKLRANLRKNRYTDVLCVEETRVPLSPVdEDDCSDYIHANFTDGY
 . | ||  |||| ..| ..|||| ||   . . |||| ||. .| 
navlsanatknryinilpfdetrvilsss.kkegsdyinanyiqgs