Gene PTPRD in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP079_AA protein Get Run
NvecP079_AA_1302-1577 phosphatase_domain Get Run
NvecP079_AA_1589-1867 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 1297-1617 3.7e-158 522.7 In-house 2-323 (564) alignment 
Range on Protein: 1297-1617
Range on HMM: 2-323/564.0
HPPISVLDLPKHIAILKADNNSQFTQEYESIEPGQTFTADSSQMECNKGKNRYPNIHAYDHSRVRLSYINGIEGSDYINANFCDGYRKERAYIATQGPMQ
..||.| .|..|.| |||... .|..||..||.||.|| .......|| |||| || |||||||.|| ..| ||||||||.|.|||||..||||||||..
skpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPla

HTAADFWRMVWEQRTFTIVMLTREEERGRVKCDQYWPTDGTDVYEGIEVSLVDWVELANYTISTLQICKEGASQPREVKHFQFTGWPDHGVPAHPTPFLA
.| .|||||||||.. ||||||. ||.|.|||..|||..||  |....|.|.. .|||.|.| |... |.  |. |||..|.|| ||||||| ..|..|.
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLd

FLRRVKFYNPPDAGPIVVHCSAGVGRTGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAVSCGNTEVHARNLLHHIKKLT
..|.|. .|.||||||||||||||||||.|||||.||||...|.|||||..|. ||.|||.||||.||||| |.|||||..||||||...|| .|..||.
lirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLa

ELG-KGEVTGLEEEFKVVDPSQ
|   . |.|||| ||. .  ..
eveedtemtgleleFqrLatak
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1300-1597 4.3e-121 398.8 In-house 2-301 (318) alignment 
Range on Protein: 1300-1597
Range on HMM: 2-301/318.0
ISVLDLPKHIAILKADNNSQFTQEYESI-EPGQTFTADSSQMECNKGKNRYPNIHAYDHSRVRLSYINGIEGSDYINANFCDGYRKERAYIATQGPMQHT
||| || .|.. |... . ....||| .    .|.|.  |  ..|| |||| || ||||.||.|. ..| |||||||||. ||||...||||.|.|. .|
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

AADFWRMVWEQRTFTIVMLTREEERGRVKCDQYWPTDGTDVYEGIEVSLVDWVELANYTISTLQICKEGASQPREVKHFQFTGWPDHGVPAHPTPFLAFL
  ||||||||| . .|||||.|||||..|...||| .|.  |. . | | . |||..|.. .... ... .. |.|. ...| |||.|||.... .|...
ieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlv

RRVKFYN-PPDAGPIVVHCSAGVGRTGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAVSCGNTEVHARNLLHHIKKLTE
|.|. .. ...|||||||||||||||| ||..|..|||...|..||... |. ||.||| ||||..||.| .|..|||. .|.|||.|..| ..|..|.|
rqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelre
subfamily_PTPRD_pd Subfamily PTPRD 1605-1871 8.6e-120 396.0 In-house 24-286 (564) alignment 
Range on Protein: 1605-1871
Range on HMM: 24-286/564.0
GLEEEFKVVDPSqaKKHKYGAATLAINRPKNRLANILPYETTRVHISPVRGVEGSDYINASFIDGYRQRGLFIATQGPLQDTVDDFWRMLMEQNSNIIVM
 .|||.| ....  ....  ||.  .|..|||.|||..|...|| .|.|.|.|||||||||||||||.|  .|||||||..|..|||||..||||..|||
kfeeeykkieeg..qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVm

LTQLHEGEWEKCYKYWPTDRSARHQYYIVDPIAEHEYPQFVIRDFKVKDARSDTVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRAYeqQEEEGPITV
||.|.| . .|| ||||...........|.. .|.|. ...||.||.|...|. .|...||||  ||..|||.|.....||| .|...   ....|||.|
ltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln..epdagPivV

HCSDGVGRTGVFTALFIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYLGSFDH
||| ||||||.| .. ..|||...|..||..|.||.||.||.||||..||| |.... ||.| ... 
hCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnt
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1299-1611 4.6e-111 365.9 In-house 4-319 (319) alignment 
Range on Protein: 1299-1611
Range on HMM: 4-319/319.0
PISVLDLPKHIAILKADNNSQFTQEYESIEPGQTFTADSSQMECNKGKNRYPNIHAYDHSRVRLSYINGIEGSDYINANFCDGYRKERAYIATQGPMQHT
.| | .| ... .|..  . .. .|.. .. ....| ||...| || ||||.|| |||..|| || ..|.||||||||.| |||......||||.|...|
eievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlent

AADFWRMVWEQRTFTIVMLTREEERGRVKCDQYWPTDGTDVYEGIEVSLVDWVELANYTISTLQIcKEGASQP--REVKHFQFTGWPDHGVPAHPTPFLA
  ||||||||......||||.  |...||. .|||.    .|  . | | .  ||..| |. |.. .. .|.   |||||||.| ||||.|| . |  |.
iedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklkl.nkkssevetRevkhfqyteWpdhdvPekatslld

FLRRVKF-YNPPDAGPIVVHCSAGVGRTGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAVSCGNTEVHARNLLHHIKKL
.|.|..   . ...||||||||||||||| |||.| ||||...|...|..  |  |||||| |||..|||.| ..|.||||..|.||.. ..| . .|.|
llkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkql

TELGKG-EVTGLEEEFK
.|   .   |||| ||.
aekvadtgetglerefq
subfamily_PTPRG_pd Subfamily PTPRG 1301-1595 6.7e-110 362.9 In-house 2-305 (563) alignment 
Range on Protein: 1301-1595
Range on HMM: 2-305/563.0
SVLDLPKHIAILKADNNSQFTQEYESIEP---GQTFTADSSQMECNKGKNRYPNIHAYDHSRVRLSYINGIEGS-DYINANFCDGYRKERAYIATQGPMQ
 | .. ||.| |.||..  |..|.|...     ....|..|| ..|| |||| || |||.|||.|| . |.... ||||||. |||.|..|.||||||..
pvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplk

HTAADFWRMVWEQRTFTIVMLTREEERGRVKCDQYWPTDGTDVYEGIEVSLVDWVELANYTISTLQICK----EGAS--QPREVKHFQFTGWPDHGVPAH
.|. |||||.|||.. .|||.|  .|||| |||.|||.|..  |. ..| |..   || ||. ||.| .    .. .  . ..|.....| ||||||| |
dtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPeh

PTPFLAFLRRVKFYNPPDAGPIVVHCSAGVGRTGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAVSCGNTEVHARNLlH
..| | | .. .  |. .|||||||||||||||| .||.|..|.....|..|...| .  .|.|||..|||.||||| |||.|||.. ..||. | .. .
slpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqv.e

HIKKL
..|. 
elknc
0051299 (Phosphotyrosine protein) phosphatases II 1297-1576 6e-106 349.3 In-house 2-286 (288) alignment 
Range on Protein: 1297-1576
Range on HMM: 2-286/288.0
HPPISVLDLPKHIAILKADNNSQFTQEYESIEPGQ-TFTADSSQMECNKGKNRYPNIHAYDHSRVRLSYINGIEGSDYINANFCDGYRKERAYIATQGPM
. .||| .| |..  |.|...... .|.| . . . ..|  ......|. ||||..| .||||||.|| ..|.||||||||.. |||...|..||||||.
dteisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPl

QHTAADFWRMVWEQRTFTIVMLTREEERGRVKCDQYWPTDGTDVYEGIEVSLVDWVELANYTISTLQICKE----GASQPREVKHFQFTGWPDHGVPAHP
..| .|||||||||.. .|||||...|.||.||.||||..|. .|. | | |.. ..|..||. ||.. .     | ...|.|.||..|.||||||| .|
pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

TPFLAFLRRVKFYNPPDAGPIVVHCSAGVGRTGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAV
...|.|||.|. ..... ||.||||||||||||.||..| .||.|..|..||... |  ||.||..|||| |||.| ..|.||..
ellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0040438 (Phosphotyrosine protein) phosphatases II 1302-1595 1.1e-104 345.5 In-house 2-295 (317) alignment 
Range on Protein: 1302-1595
Range on HMM: 2-295/317.0
VLDLPKHIAILKADNNSQFTQEYESIEPGQTFTADSSQMECNKGKNRYPNIHAYDHSRVRLSYINGIEGSDYINANFCDGYRKERAYIATQGPMQHTAAD
||||....  |.. .. .. .|.| .   .  | . .....||.|||||.|  ||||||.|| ..|...||||||.. ||... |..||||||...| .|
vldlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntved

FWRMVWEQRTFTIVMLTREEERGRVKCDQYWPTDGTDVYEGIEVSLVDWVELANYTISTLQICKEGASQPREVKHFQFTGWPDHGVPAHPTPFLAFLRRV
||||||||.. .|||||..||.||.||.||||...| .|... | |.. .|||..|. ||.. . | |..|.|.||..||||||||| .|...|.||..|
FwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleav

KFYNPPDAGPIVVHCSAGVGRTGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAVSCGNTEVHARNLLHHIKKL
. ..... ||..|||||||||||.||... |||.|..|..||..  |  || ||...||| |||.| .||.|| . ...| . | .| ....||
realedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllkl
subfamily_PTPRK_pd Subfamily PTPRK 1297-1590 3.8e-104 342.9 In-house 1-291 (314) alignment 
Range on Protein: 1297-1590
Range on HMM: 1-291/314.0
HPPISVLDLPKHIAILKADNNSQFTQEYESIEPGqtftADSSQMECNKGKNRYPNIHAYDHSRVRLSYINGIEGSDYINANFCDGYRKERAYIATQGPMQ
|| | | || ..||.||. ..  | .||||.  |     |... . |. |||. .| |||.|||.|  |.|   ||||||.. |.|.. .|.|.||||.|
hpairvadllqsiallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlq

HTAADFWRMVWEQRTFTIVMLTREEERGRVKCDQYWPTDGTDvYEGIEVSLVDWVELANYTISTLQICK--EGASQPREVKHFQFTGWPDHGVPAHPTPF
.| .||||.|..... .|||||   | ||||| .||| |..  |. |.| ||.   ||.. . .....|   | .. |||..|||.|||||.|| . | .
etvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgl

LAFLRRVKFYNPPDAGPIVVHCSAGVGRTGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAVSCGNTEVHARNLLH
|...||||  ....||.|||||||| ||||.||.||..|. ...|..||..  |  ||...  ||.|.|||.| .|.||||. ||.| . . ..  
lklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefka
subfamily_PTPRA_pd Subfamily PTPRA 1297-1610 8e-104 342.1 In-house 11-330 (330) alignment 
Range on Protein: 1297-1610
Range on HMM: 11-330/330.0
HPPISVLDLPKHIAILKADNNSQFTQEYESIEPGQ-TFTADSSQMECNKGKNRYPNIHAYDHSRVRLSYINGIEGSDYINANFCDGYRKERAYIATQGPM
..|. | .| . | | .||.| .| .|....  |.   | . .. | || |||..||  ||.||| || ..|.| |||||| | |||..   .||.||| 
yfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPk

QHTAADFWRMVWEQRTFTIVMLTREEERGRVKCDQYWPTDGTDVYEGIEVSLVDWVELANYTISTLQICKEGA----SQPREVKHFQFTGWPDHGVPAHP
..|  |||||.|||.. ||||||  .|| . || ||||..|.  |  | |.. | ..| .||.  . . . .      ..| |. | ||.||| |||..|
eetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfep

TPFLAFLRRVKFYNPPDAGPIVVHCSAGVGRTGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAVSCGNTEVHARNLLHH
   | .|..||  |.  |||||||||||||||| |||.|..|||.. |. ||... |  ||.||  ||||.||| | . ..||    |.||...  | .|
iGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekh

IKKLTE-LGKGEVTGLEEEF
..|| . . . . .||||||
lqklynkitgtdkigleeef
0050432 (Phosphotyrosine protein) phosphatases II 1290-1580 1.6e-103 341.6 In-house 16-303 (308) alignment 
Range on Protein: 1290-1580
Range on HMM: 16-303/308.0
QTPAMIDHPPISVLDLPKHIaiLKADNNSQFTQEYESIEPGQT-FTADSSQMECNKGKNRYPNIHAYDHSRVRLsyinGiEGSDYINANFCDGY--RKER
 |. .  . ..||||| |..   ||...... .|.| .   .. .. .......|| ||||..| .||||||.|    . ||||||||.. |||  ...|
dtsilvsslklsvldllkll..ekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklpr

AYIATQGPMQHTAADFWRMVWEQRTFTIVMLTREEERGRVKCDQYWPTD---GTDVYEGIEVSLVDWVELANYTISTLQICKEGASQPREVKHFQFTGWP
..||||||...| .|||||||||.. .|||||...|.||.||.||||..   |. .|... | |..  .|..||. ||.... | .. |.|.||..|.||
kfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWp

DHGVPAHPTPFLAFLRRVKFYNPPdaGPIVVHCSAGVGRTGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAVSCGN
||||| .|...|.||..|. ..|.  |||||||||||||||.||..| .||.|..| .||... |  ||.||..|||| |||.| ..|.|| ...  
dhgvPpspeilldflelvrkslpg..gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1591-1872 1.4e-102 338.0 In-house 10-286 (318) alignment 
Range on Protein: 1591-1872
Range on HMM: 10-286/318.0
HIKKLTElgKGEvTGLEEEFKVVDPSQAKKHKYGAaTLAINRPKNRLANILPYETTRVHISPVRGVEGSDYINASFIDGYRQRGLFIATQGPLQDTVDDF
|...| |  .|| . |.||.. ...|...  .. . .  .|. ||| ||||.|..|||..... |.||||||||..|||||..  .||.|.|| .|..||
hvrrlre..sGe.lllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDf

WRMLMEQNSNIIVMLTQLHEGEWEKCYKYWPTDRSARHQYYIVDPIAEHEYPQFVIRDFKVKDARSDTVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQ
|||. |||| .||||||..|   .|. .||| . |  ..   |.   | |. ..|.| |||.   .. .|...|.|.  ||..|||.|| ...||..||.
WrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvs

RAyEQQEEEGPITVHCSDGVGRTGVFTALFIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYLGSFDHY
.| .|....|||.|||| |||||||| |. |.|||.. |..||.||||| ||.||..||| ..|| |.|.. ||.| |.| .
ka.qqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdte
subfamily_PTPRB_pd Subfamily PTPRB 1299-1578 3.5e-102 336.4 In-house 6-287 (293) alignment 
Range on Protein: 1299-1578
Range on HMM: 6-287/293.0
PISVLDLPKHIAILKADNNSQFTQEYESIEP-GQTFTADSSQMECNKGKNRYPNIHAYDHSRVRLSYINGIEGSDYINANFCDGYRKERAYIATQGPMQH
||.. .. .|.. .|||.. .|..|||...  |.. . .... ..|. |||| || .||||||.|. ... .||||||||. .||. .| .||||||. .
piklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpe

TAADFWRMVWEQRTFTIVMLTREEERGRVKCDQYWPTDGTDV-YEGIEVSLVDWVELANYTISTLQICKegASQPREVKHFQFTGWPDHGVPAHPTPFLA
|  ||||||||... .|||||.  |.|.|||..|||.| ..| |  |.|.||   || ...| .|.|.|  ... |.|....|| ||||||| .....|.
tvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlld

FLRRVKFYN--PPDAGPIVVHCSAGVGRTGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAVSC
|.|.|. .     ...|||||||||||||| || .| .|.....|..|||.| |. ||..||..|||..|||| |...|. .. 
fvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1305-1583 2.4e-99 327.3 In-house 14-297 (298) alignment 
Range on Protein: 1305-1583
Range on HMM: 14-297/298.0
LPKHIAILKADNNSQFTQEYESIEPGQT----FTADSSQMECNKGKNRYPNIHAYDHSRVRLSYINGIEGSDYINANFCDGYRKERAYIATQGPMQHTAA
|.|  |. |. . .....|.. .. ..     .. . .. . || ||||..| |.|.|||.|. ... | |||||| | ..|... |.||||.|...| .
lqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetve

DFWRMVWEQRTFTIVMLTREEERGRVKCDQYWPTDGTDVYEGIEVSLVDWVELANYTISTLQICKEGASQPREVKHFQFTGWPDHGVPAHPTPFLAFLRR
||||||.|.   ||||||  || ...|. .|||..|.. |. |.|||    | |.... .|.. |.  .. |||....|| |||.|||.. |  |..||.
dFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrk

VKFyNPPDAG--PIVVHCSAGVGRTGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAVSCGNTEV
|.  .. .||  |..|.|||||||.| ||.|||.|||...|..||..  | |||..|  .|||.|||.| ..|.|||....|.|.
vra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
0043336 (Phosphotyrosine protein) phosphatases II 1299-1574 3.6e-98 323.7 In-house 1-275 (278) alignment 
Range on Protein: 1299-1574
Range on HMM: 1-275/278.0
PISVLDLPKHIAILKADNNSQFTQEYESIEPGQTFTADSSQMECNKGKNRYPNIHAYDHSRVRLSYINGIEGSDYINANFCDGYRKERAYIATQGPMQHT
|||| ||.|... |...... . .|.|..   ...| . .. ..|| ||||..| .||||||.|| ..| ..||||||.. |||.. |..||||||...|
pisvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpet

AADFWRMVWEQRTFTIVMLTREEERGRVKCDQYWPtDGTDVYEGIEVSLVDWVELANYTISTLQICKEGASQPREVKHFQFTGWPDHGVPAHPTPFLAFL
 .||||||||... ||||||...|.|||||.|||| .|. .|... | |..  .|..||. || . . | ...|.| |....|||||||| .....| ||
vedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldfl

RRVKFYNPPDAGPIVVHCSAGVGRTGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILE
..|. ..... ||..|||||||||||.||... .||.|..| .||..  |  ||.||  .|||..||.| ..|.||
kavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
0046845 (Phosphotyrosine protein) phosphatases II 1320-1581 2.2e-97 321.1 In-house 2-279 (284) alignment 
Range on Protein: 1320-1581
Range on HMM: 2-279/284.0
FTQEYESIEPGQTF---TADSSQMECNKGKNRYPNIHAYDHSRVRLSYING-IEGSDYINANFCDGY-----RKERAYIATQGPMQHTAADFWRMVWEQR
. .|.| .   ...   . . .....|. ||||..| .||||||.|. ..| .|.||||||.. |||     ......||||||...| .|||||||||.
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

TFTIVMLTREEERGRVKCDQYWPTDG-TDVYEGIEVSLVDWVELANYTISTLQICKEG-ASQPREVKHFQFTGWPDHGVPAHPTPFLAFLRRVKFYNP--
. .|||||...|.||.||.||||..| . .|... | |..  .  .||. ||.. ..|  ...|.|.||..|.|||||||..|...|.||| |. ...  
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

PDAGPIVVHCSAGVGRTGCFIVIDSMLERLRHEE---TVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAVSCGNT
|. |||||||||||||||.||..| .||.|..|.   .||... |  ||.||..|||| |||.| ..|.||......|
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1601-1870 3.1e-97 320.5 In-house 20-287 (319) alignment 
Range on Protein: 1601-1870
Range on HMM: 20-287/319.0
GEVTGLEEEFKVVDPSQAKkhKYGAATLAINRPKNRLANILPYETTRVHISPVRGVEGSDYINASFIDGYRQRGLFIATQGPLQDTVDDFWRMLMEQNSN
   |.||.||| .. ....  ..  |.  .|..|||  |||.|. ||| .|.. ||||||||||||||||..|  |||||.||..|..|||||. |..| 
tgetllekefkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeess

IIVMLTQLHEGEWEKCYKYWPTDRSARHQYYIVDPIAEHEYPQFVIRDFKVKDARSDT-VRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRAYEQqEEE
|.||||.| |    |. ||||.    .   .||..  |.|  ...||..|.. . |.   |..|.|... ||. .||... ...||....... |. ...
ivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrek.tqs

GPITVHCSDGVGRTGVFTALFIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYLGSFD
|||.||||.|||||| | .|...|||.. |||.|.|.||. |||||. ||| .||| |.|.. ||.. ..|
gPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd
0036941 (Phosphotyrosine protein) phosphatases II 1311-1589 1.9e-96 318.1 In-house 6-290 (297) alignment 
Range on Protein: 1311-1589
Range on HMM: 6-290/297.0
ILKADNNSQFTQEYESIEPGQ-TFTADSSQMECNKGKNRYPNIHAYDHSRVRLsyiNGiEGSDYINANFCDGYRKERAYIATQGPMQHTAADFWRMVWEQ
. |....... .|.|.. | .  .. . .. ..|. ||||..| .|||.||.|   .. ||||||||.. |||. .|..||||||...| .|||||||||
lekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl...dd.egsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweq

RTFTIVMLTREEERGRVKCDQYWPTD--GTDVYEGIEVSLVDWVE--LANYTISTLQICKEGASQPREVKHFQFTGWPDHGVPAHPTPFLAFLRRVKFYN
.. .|||||...|.||.||.||||..  .. .|... | |..  .  |..||. ||.. . | ...|.|.||..||||||||| .|...|.|...|. ..
nvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvl

PP--DAGPIVVHCSAGVGRTGCFIVIDSMLERLR---HEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAVSCGNTEVHARNLL
.   . ||..|||||||||.|.||..| ||..|.   .|..|||.  |  ||.||. .||| |||.| ..|.|| . ...| . ...| 
kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllklv
0039614 (Phosphotyrosine protein) phosphatases II 1289-1580 1.5e-95 315.3 In-house 3-293 (297) alignment 
Range on Protein: 1289-1580
Range on HMM: 3-293/297.0
FQTPAMIDHPPISVLDLPKHIAILKADNNSQFTQEYESIEPGQTfTADSSQMECNKGKNRYPNIHAYDHSRVRLSYINGI-EGSDYINANFCDGYRK-ER
. ..|. ...||..  |. .. ..||...... .|.|..   .      .. ..|| ||||..| .||||||.|. ..|  ..||||||.. |||..  |
plrdallesipiplsvldlllllekansktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltr

AYIATQGPMQHTAADFWRMVWEQRTFTIVMLTREEERGRvKCDQYWPTDGTdVYEGIEVSLVDWVELANYTISTLQICKegASQPREVKHFQFTGWPDHG
..||||||...| .|||||||||.. .|||||...|.|| ||.||||..|. .|... | |... .|..||. || . .   ...|.|.|||.|||||||
kfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhg

VPAHPTPFLAFLRRVKFYNP--PDAGPIVVHCSAGVGRTGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAVSCGN
|| ... .| ||. |. ..   |. ||..|||||||||||.||... |||.|..| .||..  |  || ||...||| .||.| .||.|| .....
vppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
0051299 (Phosphotyrosine protein) phosphatases II 1579-1866 4.1e-95 313.8 In-house 1-286 (288) alignment 
Range on Protein: 1579-1866
Range on HMM: 1-286/288.0
GNTEVHARNLLHHIKKLTelgKGEVTGLEEEFKVVDPSQAKkHKYGAATLAINRPKNRLANILPYETTRVHISPVRGVEGSDYINASFIDGYRQRGLFIA
|.||.....|| ...||.   .. .|||.|||. . . ... ... || |  |..|||  .||||. .||..|.. |||||||||||.||||..   |||
gdteisveellklvlkll...angltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIa

TQGPLQDTVDDFWRMLMEQNSNIIVMLTQLHEGEWEKCYKYWPTDRSARHQYYIVDPIAEHEYPQFVIRDFKVKDA----RSDTVRNIKQFHFLGWPETG
|||||..||.|||||..|||...|||||.|.| . |||..|||.. |  .  . |  . |.... ...| ..|..      ....|....||...||. |
tqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhg

VPKSGEGIIDLIGQVQRAYEqqEEEGPITVHCSDGVGRTGVFTALFIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYL
|| | | ..|.. .|..|..    .||. ||||.||||||.| ||...||... ||.||....|| ||.||| |||. |||.|.|...||||
vpdspellldflrlvrkala..sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0047943 (Phosphotyrosine protein) phosphatases II 1313-1575 1.7e-94 311.6 In-house 7-271 (273) alignment 
Range on Protein: 1313-1575
Range on HMM: 7-271/273.0
KADNNSQFTQEYESIEPGQT-FTADSSQMECNKGKNRYPNIHAYDHSRVRLsyinGIEGSDYINANFCDGYRKERAYIATQGPMQHTAADFWRMVWEQRT
|....... .|.| . . .. .|   .....|| ||||..| .||||||.|    | .|||||||.. |||...|..||||||...| .|||||||||..
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv

FTIVMLTREEERGRVKCDQYWPTDG---TDVYEGIEVSLVDWVELANYTISTLQICKEGASQPREVKHFQFTGWPDHGVPAHPTPFLAFLRRVKFYNPP-
 .|||||...|.||.||.||||..|   . .|. . | |..  . ..||. ||.. . | ...|.|.||..|||||||||......| |.. |. ..   
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkaleal

-DAGPIVVHCSAGVGRTGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEA
 . ||.||||||||||||.||..| .|..|..| .||..  |  ||.|| .|||| |||.| ..|.|| 
psngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
0045450 (Phosphotyrosine protein) phosphatases II 1297-1576 4e-94 311.0 In-house 6-304 (307) alignment 
Range on Protein: 1297-1576
Range on HMM: 6-304/307.0
HPPISVLDLPKHIAILKADNNSQFTQEYESIEPGQTF---TADSSQMECNKGKNRYPNIHAYDHSRVRLSYINGI-EGSDYINANFC--------DGYRK
...|..|.| .....|..|... . .|.|.. . ..|   . .......|| ||||..| .|||.||.|| ..|  |.||||||..         |||..
slfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydl

ERAYIATQGPMQHTAADFWRMVWEQRTFTIVMLTREEERGRVKCDQYWPTDGTD-VYEGIEVSLVDWVELANYTISTLQICKE-GASQPREVKHFQFTGW
 |..||||||...| .|||||.|||.. .|||||...|.||.||.||||..|.  .|. . | |..  .|..||. || .    | ...|.|.||..|||
krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgw

PDHGVPAHPTPFLAFLRRVKFYNPP--DAGPIVVHCSAGVGRTGCFIVIDSMLERLRHEET---VDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAV
|||||| .. ..|.|...|. ..    . ||..|||||||||||.||... ||..|..|.|   ||..  |  || ||  .||..|||.| ..|.|| .
pdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1299-1596 1.4e-93 308.4 In-house 3-303 (305) alignment 
Range on Protein: 1299-1596
Range on HMM: 3-303/305.0
PISVLDLPKHIAILKADNNSQFTQEYESIEPGqTFTADSSQMECNKGKNRYPNIHAYDHSRVRLSYINGIEGSDYINANFCDGYRKERAYIATQGPMQHT
.|.. || ..|   ........ ..|.|.      . |  . | || |||. .|  .|..|..|.  .  . ||||||.. |||... .||..|||...|
iialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlknt

AADFWRMVWEQRTFTIVMLTREEERGRVKCDQYWPTDGTD--VYEGIEVSLVDWVELANYTISTLQICK-EGASQPREVKHFQFTGWPDHGVPAHPTPFL
 |||||...| .. ||||||.  | |. || ||||.  |.   .. ..| | .  . ..|..  |.|.. .. .. | | ..|.| |||||||  .| .|
vadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsll

AFLRRVKFYNPPDAG-PIVVHCSAGVGRTGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAVSCGNTEVHARNLLHHIKK
 ...||.     | | |..||||||||||| ||..| .||||..||.||... .  ||..| .||||..|| | |||. | . ||.|..   ||  ...|
slikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvnk

LT
| 
lk
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1579-1873 6.8e-93 306.2 In-house 1-297 (298) alignment 
Range on Protein: 1579-1873
Range on HMM: 1-297/298.0
GNTEVHARNLLHHIKKLTELGK-GEVTGLEEEFKVVDPSQA--KKHKYGAATLAINRPKNRLANILPYETTRVHISPVRGVEGSDYINASFIDGYRQRGL
||||..|..| ....||..  |  ..||...||. ..  .   ..... .|    |. ||| |.|.... .|| .. . . | ||||||||...|..|  
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

FIATQGPLQDTVDDFWRMLMEQNSNIIVMLTQLHEGEWEKCYKYWPTDRSARHQYYIVDPIAEHEYPQFVIRDFKVKDARSDTVRNIKQFHFLGWPETGV
|||||.||. || |||||..|.... |||||.|.| .  |. ||||.......    |.  ...|. ....| .||....... |...|.||  ||. ||
fiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgv

PKSGEGIIDLIGQVQRaYEQQEEEGPITVHCSDGVGRTGVFTALFIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYLGSFDHYA
|.  . ..||. .|.. ..||  . |..|.||.||||.| | |.  ||||.. | |||.||.|| ||..||..||..||| |.|.  ||.| ||. ..
penatsvldllrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
0050432 (Phosphotyrosine protein) phosphatases II 1591-1870 1.4e-92 305.6 In-house 34-303 (308) alignment 
Range on Protein: 1591-1870
Range on HMM: 34-303/308.0
HIKKltelgKGEVTGLEEEFKVVDPSQAkKHKYGAATLAINRPKNRLANILPYETTRVHIspvrGvEGSDYINASFIDGY--RQRGLFIATQGPLQDTVD
...|     . . ..|||||. .   .   ..| .| |  |..|||  .||||. .||..    . |||||||||..|||  ...  ||||||||..||.
llek.....aldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatqgPlpntve

DFWRMLMEQNSNIIVMLTQLHEGEWEKCYKYWPTD---RSARHQYYIVDPIAEHEYPQFVIRDFKVKDARSDTVRNIKQFHFLGWPETGVPKSGEGIIDL
|||||..|||...|||||.|.| . |||..|||..    | .. .. |  . |.... ...| ..... ... .| ...||...||. ||| | | ..|.
dFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldf

IGQVQRAYeqqeEEGPITVHCSDGVGRTGVFTALFIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYLGSFD
. .|.. .    ..||| ||||.||||||.| || ..||... || ||.|..|| ||.||| |||. |||||.|...|||| .. 
lelvrksl....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
subfamily_PTPRA_pd Subfamily PTPRA 1607-1865 1.4e-92 305.1 In-house 35-294 (330) alignment 
Range on Protein: 1607-1865
Range on HMM: 35-294/330.0
EEEFKVVdPSQAKKHKYGAATLAINRPKNRLANILPYETTRVHISPVRGVEGSDYINASFIDGYRQRGLFIATQGPLQDTVDDFWRMLMEQNSNIIVMLT
 |||. . |.   .  . .|.   |. |||. |||||. .||..|...||| ||||||||||||...  |||.|||...||.|||||. ||.|  |||||
reefnal.PagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmlt

QLHEGEWEKCYKYWPTDRSARHQYYIVDPIAEHEYPQFVIRDFKVK---D-ARSDTVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRAyeQQEEEGPI
.|.| . |||..|||.. .  .    |    | .  .. .|.| |.   | .| ...| ..|||| .||. |||  . |...|. .|..   .| . |||
elkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkkl..nqqsagpi

TVHCSDGVGRTGVFTALFIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEY
.|||| |||||| | .|  ||||...|..||.|..|| ||.||| |||..||| |.||. |||
vvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
DSPc_SM00195 1320-1576 9.4e-92 302.4 In-house 2-262 (263) alignment 
Range on Protein: 1320-1576
Range on HMM: 2-262/263.0
FTQEYESIEPGQ-TFTADSSQMECNKGKNRYPNIHAYDHSRVRLSYINGIEGSDYINANFCDGYRKERAYIATQGPMQHTAADFWRMVWEQRTFTIVMLT
. .|.|..|  . . . .... . || |||| ||  |||.||.|. ... |||||||||. .|..|...|||||||...| .||||||||... .|||||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

REEERGRVKCDQYWPTD--GTDVYEGIEVSLVDWVELA-NYTISTLQICKEGASQPREVKHFQFTGWPDHGVPAHPTPFLAFLRRVKFYNPPDAGPIVVH
.|||.|. |||.||| .  |. ... |.| ||.  .   .... ||.. ||| ...|.|...|...||||||| .....|..|| ||  .    ||||||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGVGRTGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAV
|||||||||.|..||..|..|..|..|||   |. ||.||  ||||.|||.| ..||||..
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 1320-1576 9.4e-92 302.4 In-house 2-262 (263) alignment 
Range on Protein: 1320-1576
Range on HMM: 2-262/263.0
FTQEYESIEPGQ-TFTADSSQMECNKGKNRYPNIHAYDHSRVRLSYINGIEGSDYINANFCDGYRKERAYIATQGPMQHTAADFWRMVWEQRTFTIVMLT
. .|.|..|  . . . .... . || |||| ||  |||.||.|. ... |||||||||. .|..|...|||||||...| .||||||||... .|||||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

REEERGRVKCDQYWPTD--GTDVYEGIEVSLVDWVELA-NYTISTLQICKEGASQPREVKHFQFTGWPDHGVPAHPTPFLAFLRRVKFYNPPDAGPIVVH
.|||.|. |||.||| .  |. ... |.| ||.  .   .... ||.. ||| ...|.|...|...||||||| .....|..|| ||  .    ||||||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGVGRTGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAV
|||||||||.|..||..|..|..|..|||   |. ||.||  ||||.|||.| ..||||..
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1307-1576 3.1e-90 297.1 In-house 10-279 (288) alignment 
Range on Protein: 1307-1576
Range on HMM: 10-279/288.0
KHIAILKADNNSQFTQEYESI-EPGQTFTADSSQMECNKGKNRYPNIHAYDHSRVRLSYINGIEGSDYINANFCDGYRKERAYIATQGPMQHTAADFWRM
...|. .|.|...|..||.|. . ..| . . ..   |. ||||.|| .||. ||.|   .  .|.|||||.. ||..|...|||||||...|  |||..
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWel

VWEQRTFTIVMLTREEERGRVKCDQYWPTDGT-DVYEGIEVSLVDWVELANYTISTLQICKEGasQPREVKHFQFTGWPDHGVPAHPTPFLAFLRRVKFY
|.|..| ||||||   |.|. ||..|||....   |  ..| ||.  || ...  .| . |..  . .|....|...|||||||.  .|.|..|| ||  
vyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkk..teleitqyqylaWpdhgvPeskapllellrqvkva

NPPDAGPIVVHCSAGVGRTGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAV
|. |.|||.||||||||||| ||..| .......|...|. | |. || ||. .|||..||.| ....|. .
nqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
0046845 (Phosphotyrosine protein) phosphatases II 1605-1869 1.8e-89 295.2 In-house 1-277 (284) alignment 
Range on Protein: 1605-1869
Range on HMM: 1-277/284.0
GLEEEFKVVDPSQAKKH-KYGAATLAINRPKNRLANILPYETTRVHISPVRGV-EGSDYINASFIDGY-----RQRGLFIATQGPLQDTVDDFWRMLMEQ
||||||. .   . | . .. .| |  |. |||  .||||. .||..... |  |.|||||||..|||     ...  ||||||||..||.|||||..||
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

NSNIIVMLTQLHEGEWEKCYKYWPTDR-SARHQYYIVDPIAEHEYPQFVIRDFKVKDAR-SDTVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRAYEQ
|...|||||.|.| . |||..|||..  . ..  ..|  . |.... ...| .....   .. .| ...||...||. ||| | | ..... .|....|.
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

QEEEGPITVHCSDGVGRTGVFTALFIVLERMRSEG---VVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYLGSF
 . .||| ||||.||||||.| || ..||... ||   .||....|| ||.||| |||. |||.|.|...|||| ..
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk
subfamily_Ptp69D_pd Subfamily Ptp69D 1298-1595 2.3e-89 294.6 In-house 2-305 (307) alignment 
Range on Protein: 1298-1595
Range on HMM: 2-305/307.0
PPISVLDLPKHIAILKADNNSQFTQEYESIEPG-QTFTADSSQMECNKGKNRYPNIHAYDHSRVRLSYINGIEGSDYINANFCDGYRKERAYIATQGPMQ
..|...||.. .   | | .  ...|||..|      ..  |. . |. ||||..|.|.|. ||.|. ||| | ||||||.|  ||.... .|| |.|..
gaiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPve

HTAADFWRMVWEQRTFTIVMLTREEERGRVKCDQYWPTDGTDVYEGIEVSLVDWVELANYTISTLQICKEG-----ASQPREVKHFQFTGWPDHGVPAHP
 |. |||||..||   .||||. ..|  | ||..||| . .  |. | | ||.  .  .|.| .|.. | .       . |.|  ...|||.|  || ..
atigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPeva

TPFLAFLRRVKFYNPPDAGPIVVHCSAGVGRTGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAVSCGNTEVHARNLLHH
.  | ....|.  .  . .||||||||||||.| |. .||.|..|. |..|||.  |  || ||| .||  |||.| . |.|.  | |.|..  ..| ..
rgllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddleda

IKKL
|..|
ierl
0040438 (Phosphotyrosine protein) phosphatases II 1599-1866 2.7e-88 291.6 In-house 13-276 (317) alignment 
Range on Protein: 1599-1866
Range on HMM: 13-276/317.0
GKGEVTGLEEEFKVVDPSQAKkhKYGAATLAINRPKNRLANILPYETTRVHISPVRGVEGSDYINASFIDGYRQRGLFIATQGPLQDTVDDFWRMLMEQN
 |. .|.|.|||. ..  .     |  | |  |..|||  .||||. .||..||. |...|||||||..||....  ||||||||..||.|||||..||.
lksdftalleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqg

SNIIVMLTQLHEGEWEKCYKYWPTDRSARHQYYIVDPIAEHEYPQFVIRDFKVKDARSDTVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRAYEqqEE
...|||||.| | . |||..|||.. .  .  ..|  . |.|.. ...| ..|.| .....| ...||..|||. |||.| . ..|.. .|..|.|  ..
vtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale..dp

EGPITVHCSDGVGRTGVFTALFIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYL
.||. ||||.||||||.| |....||... || ||....|| || ||| .||. ||| |.|. .||||
ggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
0040439 (Phosphotyrosine protein) phosphatases II 1337-1576 9.4e-88 289.2 In-house 5-246 (249) alignment 
Range on Protein: 1337-1576
Range on HMM: 5-246/249.0
SSQMECNKGKNRYPNIHAYDHSRVRLSYINGIEGSDYINANFCDGYRKERAYIATQGPMQHTAADFWRMVWEQRTFTIVMLTREEERGRVKCDQYWPTDG
 .....|| |||||.| .||||||.|| ..| ..||||||.. |||.  |..||||||...| .|||||.||..  .|||||...|.||.||.||||..|
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplgg

TDVYEGIEVSLVDWVELANYTISTLQICKEGASQPREVKHFQFTGWPDHGVPAHPTPFLAFLRRVKFYNP--PDAGPIVVHCSAGVGRTGCFIVIDSMLE
. .|... | |..  ....||. ||.. . . ...|.|.|.|.|.||||||| .. ..|.|...|. ..   |. ||..|||||||||||.||... |||
sleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmle

RLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAV
.|..| .||..  |  ||.||...||..|||.| ..|.|| .
qlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1341-1578 1.1e-87 288.4 In-house 7-244 (250) alignment 
Range on Protein: 1341-1578
Range on HMM: 7-244/250.0
ECNKGKNRYPNIHAYDHSRVRLSYINGIEGSDYINANFCDGYRKERAYIATQGPMQHTAADFWRMVWEQRTFTIVMLTREEERGRVkCDQYWPTDGTDVY
  || |||| .| |.|.||| |   .| . |||||| | .||....|.||||||.|.|  ||||||.|. . ||||||  .| ... . ||||..... |
pqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaeky

EGIEVSLVDWVELANYTISTLQICKEGASQPREVKHFQFTGWPDHGVPAHPTPFLAFLRRVKFYNPP-DAGPIVVHCSAGVGRTGCFIVIDSMLERLRHE
 .. ||| .  | |.||. .|.. |.  .. | |....|. ||| |||.. |  |..|..|.  ..  ...|..|.|||||||.|.||.||..||||..|
GdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkke

ETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAVSC
..||..  . |||..|  .|...|||.| . .||.|. .
kvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_PTPN9_pd Subfamily PTPN9 1311-1574 2e-87 288.0 In-house 9-288 (297) alignment 
Range on Protein: 1311-1574
Range on HMM: 9-288/297.0
ILKADNNSQFTQEYESIEPG-QTFTADSSQMECNKGKNRYPNIHAYDHSRVRLSYINGIEGSDYINANFCDGYRKERAYIATQGPMQHTAADFWRMVWEQ
 .|. ...  ..||. |     . |.. |.. .|  |||| ..  ||..|| |. ... | ||||||||.|||....|.||||||...|  |||||||||
yvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeq

RTFTIVMLTREEERGRVKCDQYWP--TDGTDVYEGIEVSLVDWVELANYTISTLQICKEGASQPREVKHFQFTGWPDHGVPAHPTPFLAFLRRVKFY---
....||| || .||||.|| ||||  .. .. .  ..|| |. .|  .|....|.| .   .. |.| ||||..|||.|||   . .| .|. |. .   
evlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqal

----------NPPDAGPIVVHCSAGVGRTGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILE
           .|.  |||||||||.|||| || .|  |.||....|||.   |  ||||| ...||.||| | . |.||
avkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
0047943 (Phosphotyrosine protein) phosphatases II 1602-1866 6.7e-87 286.7 In-house 10-272 (273) alignment 
Range on Protein: 1602-1866
Range on HMM: 10-272/273.0
EVTGLEEEFKVVdPSQAKKHKYGAATLAINRPKNRLANILPYETTRVHIspvrGVEGSDYINASFIDGYRQRGLFIATQGPLQDTVDDFWRMLMEQNSNI
 .|.|.|||. . .|. . ..| .| |  |. |||  .||||. .||..    | .||||||||..|||..   ||||||||..||.|||||..|||...
gltllleefell.lslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrv

IVMLTQLHEGEWEKCYKYWPTDR---SARHQYYIVDPIAEHEYPQFVIRDFKVKDARSDTVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRAYEQQEE
|||||.|.| . |||..|||..    | ..  ..|  . |.... ...| .....  .. .| ...||..|||. ||| | | ....| .|..|.|.  .
iVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealps

EGPITVHCSDGVGRTGVFTALFIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYL
.||. ||||.||||||.| ||...|.... || ||....|||||.||| |||. |||.|.|...||||
ngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1297-1593 1.3e-86 285.4 In-house 3-296 (315) alignment 
Range on Protein: 1297-1593
Range on HMM: 3-296/315.0
HPPISVLDLPKHIAILKADNNSQFTQEYESIEPGQTFTADSSQMECNKGKNRYPNIHAYDHSRVRLSYINGIEGSDYINANFCDGYRKERAYIATQGPMQ
| || . .|  ..|  ||  .  | |.||||  || .  | ..   || |||| || |||.|||.|  ..  ..|||.|||| ||| |.| |||.|||  
hqpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnv

HTAADFWRMVWEQRTFTIVMLTREEERGRVKCDQYWPTDgTDVYEGIEVSLVDWVELANYTISTLQICKegASQPREVKHFQFTGWPDHGVPAHPTPFLA
 .  ||||.|.|.   .|||||   |. . |...||| .   .|  | |....     .||. || .     .. |||  ...| ||| |||.. .|.. 
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtlsvvf..gdnirevvqlhytswpdmgvpkytiplmn

FLRRVKFYNPPDAGPIVVHCSAGVGRTGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAVSCGNTEVHARNLLHHIK
. |.|| ..  ..|.||||||||||||| || .|..|...  |. .|.|  .| .| .|  |||. ||| | .||.||.. ||.| .  .  |.. .
lirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqryd
Y_phosphatase Protein-tyrosine phosphatase 1343-1574 1.4e-86 285.1 Pfam-A 1-235 (235) alignment 
Range on Protein: 1343-1574
Range on HMM: 1-235/235.0
NKGKNRYPNIHAYDHSRVRLsyiNGIEG-SDYINANFCDGYRKERAYIATQGPMQHTAADFWRMVWEQRTFTIVMLTREEERGRVKCDQYWP--TDGTDV
|| ||||..| .||..||.|   .| || |||||||. .||......||||||...| .|||||||.... .|||||..||.||.||.||||  ....  
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YEGIEVSLV-DWV-ELANYTISTLQICKEGAS-QPREVKHFQFTGWPDHGVPAHPTPFLAFLRRVKFYNPPDAGPIVVHCSAGVGRTGCFIVIDSMLERL
|. |.| |. .   . ..||...|.. |.... ..||||....|.|||||||..|...| ..|.|. .. .. ||.||||||||||||.|...| .||.|
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

RHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILE
..||.||..  |  ||.||. |||. ||||| ..||||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 1343-1574 1.4e-86 285.1 In-house 1-235 (235) alignment 
Range on Protein: 1343-1574
Range on HMM: 1-235/235.0
NKGKNRYPNIHAYDHSRVRLsyiNGIEG-SDYINANFCDGYRKERAYIATQGPMQHTAADFWRMVWEQRTFTIVMLTREEERGRVKCDQYWP--TDGTDV
|| ||||..| .||..||.|   .| || |||||||. .||......||||||...| .|||||||.... .|||||..||.||.||.||||  ....  
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YEGIEVSLV-DWV-ELANYTISTLQICKEGAS-QPREVKHFQFTGWPDHGVPAHPTPFLAFLRRVKFYNPPDAGPIVVHCSAGVGRTGCFIVIDSMLERL
|. |.| |. .   . ..||...|.. |.... ..||||....|.|||||||..|...| ..|.|. .. .. ||.||||||||||||.|...| .||.|
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

RHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILE
..||.||..  |  ||.||. |||. ||||| ..||||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1305-1576 2.4e-86 284.3 In-house 2-276 (281) alignment 
Range on Protein: 1305-1576
Range on HMM: 2-276/281.0
LPKHIAILKADNNSQFTQEYESIEP-GQTFTADSSQMECNKGKNRYPNIHAYDHSRVRLSYINGIEGSDYINANFCDGYRKERAYIATQGPMQHTAADFW
| ||.. |....|. |..|||...  |.  || .|. . |. |||| || |||..||...  .  . .|||||||..||..|..|||||||. .. ..||
lrkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafW

RMVWEQRTFTIVMLTREEERGRVKCDQYWPTDG-TDVYEGIEVSLVDWVELANYTISTLQIcKEGASQPREVKHFQFTGWPDHGVPAHPTPFLAFLRRV-
.|||||.  .|||.||| | |..|| .||| |  .  |  . |. . . | |.|   .... ..  ...|||.....| |||||||| .. .| | . | 
qmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevl

KFYNPPDAGPIVVHCSAGVGRTGCFIVIDSMLERLR-HEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAV
|. ..    |.|.||||||||||..| .| .....  ..|..|.   |. || .||.||||  || | . |.|.|.
kltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
0045098 (Phosphotyrosine protein) phosphatases II 1324-1580 6.8e-86 283.3 In-house 14-276 (278) alignment 
Range on Protein: 1324-1580
Range on HMM: 14-276/278.0
YESIEPGQTFTADSSQMECNKGKNRYPNIHAYDHSRVRlsyingiegsDYINANFCDGYrkERAYIATQGPMQHTAADFWRMVWEQRTFTIVMLTREEER
.. . .|.  .   .....|. ||||..| .||||||.          |||||.. |||   ...||||||...|.||||||.||... .|||||...|.
efllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvel

GRVKCDQYWPTDGTDVYEGIEVSLVDWVELANYTISTLQICKE----GASQPREVKHFQFTGWPDHGVPAHP--TPFLAFLRRVKFYNP-----------
||.||.|||| .|. .|....| |... .| .||. || ..         ..|.|.|.....||||||| .|  ..|| .|.... ..            
grekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssll

--PDAGPIVVHCSAGVGRTGCFIVIDSMLERLrhEETVDIYGHVTVLRTQRNY-MVQTQEQYIFSHDAILEAVSCGN
  .. ||..|||||||||||...... |||.|  |..||..  |. ||.||.. .||..|||.| ....|| ...|.
lldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrgk
0042113 (Phosphotyrosine protein) phosphatases II 1337-1575 1.2e-85 282.1 In-house 3-242 (245) alignment 
Range on Protein: 1337-1575
Range on HMM: 3-242/245.0
SSQMECNKGKNRYPNIHAYDHSRVRLSYINGIEGSDYINANFCDGYRKERAYIATQGPMQHTAADFWRMVWEQRTFTIVMLTREEERGRVKCDQYWPTDG
... ..|| ||||..| .|||.||.|| ..| ..||||||.. ||||  . .||||||...| .|||||.||..  ||||||.|||.|||||.||||...
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplge

TDVYEGIEVSLVDWVELANYTISTLQICKEGASQPREVKHFQFTGWPDHGVPAHPTPFLAFLRRVKFYNP-PDAGPIVVHCSAGVGRTGCFIVIDSMLER
. .|... | |..   |..||. ||.. ..| ...||| |.....||||||| ..  .| ||..|. .   .. ||..|||||||||||.||... |||.
sltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleq

LRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEA
|..| .|...  |  || ||  .|||..||.| ..|.|| 
lekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
0045450 (Phosphotyrosine protein) phosphatases II 1586-1866 1.9e-85 282.6 In-house 9-304 (307) alignment 
Range on Protein: 1586-1866
Range on HMM: 9-304/307.0
RNLLHHIKKLTELGKGEVTGLEEEFKVVDPSQAK-KHKYGAATLAINRPKNRLANILPYETTRVHISPVRGV-EGSDYINASFI--------DGYRQRGL
...|. .. . .| .  .|||..||. . . . .  ..| .| |  |..|||  .||||. |||..|.. |  |.|||||||..        |||..   
idalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrk

FIATQGPLQDTVDDFWRMLMEQNSNIIVMLTQLHEGEWEKCYKYWPTDRSA-RHQYYIVDPIAEHEYPQFVIRDFKVKDA-RSDTVRNIKQFHFLGWPET
||||||||..||.|||||| ||....|||||.| | ..|||..|||....   .  . |  . |.... ...| ..|.|   .. .| ...||..|||..
fIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdh

GVPKSGEGIIDLIGQVQRAYEQQEEEGPITVHCSDGVGRTGVFTALFIVLERMRSEGV---VDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYL
|||.| | ..|.| .|..|.|.  ..||. ||||.||||||.| |....|.....||.   |||...||||| ||| .||..||| |.|. .||.|
gvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
0043336 (Phosphotyrosine protein) phosphatases II 1589-1866 3.8e-85 281.0 In-house 5-277 (278) alignment 
Range on Protein: 1589-1866
Range on HMM: 5-277/278.0
LHHIKKLTELGKGEVTGLEEEFKVVDPSQAkkHKYGAATLAINRPKNRLANILPYETTRVHISPVRGVEGSDYINASFIDGYRQRGLFIATQGPLQDTVD
 . .| | ||.... |.|..||. ..  .     |  | |  |..|||  .||||. .||..|.. |...|||||||..|||..   ||||||||..||.
kdllkallelllnlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetve

DFWRMLMEQNSNIIVMLTQLHEGEWEKCYKYWPtDRSARHQYYIVDPIAEHEYPQFVIRDFKVKDARSDTVRNIKQFHFLGWPETGVPKSGEGIIDLIGQ
|||||. |.....|||||.| | ...||..||| . | ..  . |  . |.... ...|...|.. ... .| . ..|.||||. ||| | . ..|.. .
dFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflka

VQRAYEqqEEEGPITVHCSDGVGRTGVFTALFIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYL
|..|.|   ..||. ||||.||||||.| ||...||....|| |||...|| ||.||| .||...|| |.|. .||||
vreale..dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_PTPRB_pd Subfamily PTPRB 1582-1866 7.7e-85 279.5 In-house 6-285 (293) alignment 
Range on Protein: 1582-1866
Range on HMM: 6-285/293.0
EVHARNLLHHIKKLTElgkGEVTGLEEEFKVVDPSqAKKHKYGAATLAINRPKNRLANILPYETTRVHISPVRGVEGSDYINASFIDGYRQRGLFIATQG
....... .|.||...    . ... ||.. .     |...  ||.||.|| |||  |||||...||....... .|||||||..|.||...  ||||||
piklekfeehvkkmka...dsdlrfseeyeelkav.gkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqG

PLQDTVDDFWRMLMEQNSNIIVMLTQLHEGEWEKCYKYWPTDRS-ARHQYYIVDPIAEHEYPQFVIRDFKVKDarSDTVRNIKQFHFLGWPETGVPKSGE
|| .||||||||..|..|.|||||||| |.  .|| .|||.|..   .    |. .||.|. ..|||..|..   ... |...|.||. ||. |||.. .
PlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektk

GIIDLIGQVQRAYEQQEEEGPITVHCSDGVGRTGVFTALFIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYL
 ..|.. .|..| |......||.|||| ||||||.| ||  .|.....| .||.| .|  ||..|  .||...||.| ... |..|
tlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll
0039614 (Phosphotyrosine protein) phosphatases II 1602-1869 1.9e-84 278.9 In-house 30-292 (297) alignment 
Range on Protein: 1602-1869
Range on HMM: 30-292/297.0
EVTGLEEEFKVVDPSQAKkhkYGAATLAINRPKNRLANILPYETTRVHISPVRGV-EGSDYINASFIDGYRQ-RGLFIATQGPLQDTVDDFWRMLMEQNS
. |.|..||. .   .     |  | |  |..|||  .||||. .||...|..|| ..|||||||..|||..    ||||||||..||.|||||. ||..
sktllllefeellslkpd...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgv

NIIVMLTQLHEGEWeKCYKYWPTDRSaRHQYYIVDPIAEHEYPQFVIRDFKVKDarSDTVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRAYEQQEEE
..|||||.| | .. ||..|||.. . ..  . |  . ..... ...| ..|..  .. .| ...|...|||. ||| | | ..... .|..|... ...
tvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkg

GPITVHCSDGVGRTGVFTALFIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYLGSF
||. ||||.||||||.| |....||....|| ||....|| || ||| .||. .|| |.|. .||.|  .
gpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
0036941 (Phosphotyrosine protein) phosphatases II 1602-1869 5.3e-84 277.3 In-house 11-280 (297) alignment 
Range on Protein: 1602-1869
Range on HMM: 11-280/297.0
EVTGLEEEFKVVDPSQAkKHKYGAATLAINRPKNRLANILPYETTRVHIspvrGVEGSDYINASFIDGYRQRGLFIATQGPLQDTVDDFWRMLMEQNSNI
  ..|..||. ..| ..   .. .| |  |..|||  .||||. |||..    . |||||||||..|||..   ||||||||..||.|||||..|||...
flalllkefeellplll.lgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtv

IVMLTQLHEGEWEKCYKYWPTD--RSARHQYYIVDPIAEHE--YPQFVIRDFKVKDARSDTVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRAYEQQE
|||||.| | . |||..|||..   |  .  ..|  . ...  .. ...| ..|.| ... .| ...||..|||. ||| | . ..|.| .|......  
Ivmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllp

EEGPITVHCSDGVGRTGVFTALFIVLERMR---SEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYLGSF
..||. ||||.||||.|.| |....|....    || ||....|| ||.||| .||. |||.|.| . ||.| ..
sggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1315-1588 1.1e-83 276.2 In-house 31-303 (319) alignment 
Range on Protein: 1315-1588
Range on HMM: 31-303/319.0
DNNSQFTQEYESIE--PGQTFTADSSQMECNKGKNRYPNIHAYDHSRVRLSYINGIEGSDYINANFCDGYRKERAYIATQGPMQHTAADFWRMVWEQRTF
|. ...  |.  .   . .  . . . .. || |||. || |.|...|.|  ..|.|.|||||| | .||...  |||.|||.. | ||||||.||... 
ddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncs

TIVMLTreeergRVKCDQYWPTDGTDVYEGIEVSLVDWVELANYTISTLQICKEGA-SQPREVKHFQFTGWPDHGVPAHPTPFLAFLRRVKFYNPPD--A
|||.||      . || |||| ..   .|  .|..    | |.|..  ... ..|   . |... | | ||||.||| .|.... ....|.  .      
tivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhr

GPIVVHCSAGVGRTGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAVSCGNTEVHARNL
 .||||||||||||| .||.| .|.|...|. ||.|  |  || ||| .||   || | . |.||    |...|   ..
anivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdf
DSPc_SM00195 1606-1866 9.8e-83 272.8 In-house 2-262 (263) alignment 
Range on Protein: 1606-1866
Range on HMM: 2-262/263.0
LEEEFKVVDPSQAKKhKYGAATLAINRPKNRLANILPYETTRVHISPVRGVEGSDYINASFIDGYRQRGLFIATQGPLQDTVDDFWRMLMEQNSNIIVML
|.|||. .. |. .| .   |    |. |||  |||||. |||....  . ||||||||..|.|....  .|||||||..||.||||| .|....|||||
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

TQLHEGEWEKCYKYWPTD--RSARHQYYIVDPIAEHEYP-QFVIRDFKVKDARSDTVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRAYEQQeeEGPI
|.  | . |||..||| .  .. ..... |  . ..... ....|.....    .. |...|... .||. |||.| . ...|. .|.  ....  .|||
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpi

TVHCSDGVGRTGVFTALFIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYL
 ||||.||||||.| .. |.|.....|  ||.|..|| ||.||| |||..|||||.|...|||.
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 1606-1866 9.8e-83 272.8 In-house 2-262 (263) alignment 
Range on Protein: 1606-1866
Range on HMM: 2-262/263.0
LEEEFKVVDPSQAKKhKYGAATLAINRPKNRLANILPYETTRVHISPVRGVEGSDYINASFIDGYRQRGLFIATQGPLQDTVDDFWRMLMEQNSNIIVML
|.|||. .. |. .| .   |    |. |||  |||||. |||....  . ||||||||..|.|....  .|||||||..||.||||| .|....|||||
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

TQLHEGEWEKCYKYWPTD--RSARHQYYIVDPIAEHEYP-QFVIRDFKVKDARSDTVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRAYEQQeeEGPI
|.  | . |||..||| .  .. ..... |  . ..... ....|.....    .. |...|... .||. |||.| . ...|. .|.  ....  .|||
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpi

TVHCSDGVGRTGVFTALFIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYL
 ||||.||||||.| .. |.|.....|  ||.|..|| ||.||| |||..|||||.|...|||.
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1334-1590 3e-82 271.3 In-house 16-269 (284) alignment 
Range on Protein: 1334-1590
Range on HMM: 16-269/284.0
TADSSQMECNKGKNRYPNIHAYDHSRVRLSYINGIEGSDYINANFCDGYRKERAYIATQGPMQHTAADFWRMVWEQRTFTIVMLTreeergRVKCDQYWP
.   . .. || |||. .| |.|...|.|  . |.|.|||||| |  ||...  |||||||.. | ||||||.||... |||.||      . || ||||
dqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywp

TDGTDVYEGIEVSLVDWVELANYTISTLQICKEGA-SQPREVKHFQFTGWPDHGVPAHPTPFLAFLRRVKFYNPPD--AGPIVVHCSAGVGRTGCFIVID
 ..   .|  .|..    | ..|..  ... ..|   . |... | | ||||.||| .|.........|.  .       .||||||||||||| .||.|
lkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivld

SMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAVSCGNTEVHARNLLH
 .|.|...|. ||.|  |  || ||| .||   || | . |.||    |...|   ..  
vlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpa
subfamily_PTPRG_pd Subfamily PTPRG 1593-1868 1.5e-81 269.3 In-house 8-289 (563) alignment 
Range on Protein: 1593-1868
Range on HMM: 8-289/563.0
KKLTELGKGEVTGLEEEFK-VVDPSQAKKHKYGAATLAINRPKNRLANILPYETTRVHISPVRGVEGS-DYINASFIDGYRQRGLFIATQGPLQDTVDDF
| ...|   . .|..|||. ..  ...|. .. ..    |. |||  ||..|. .||..||. |.... |||||..||||..   ||||||||.||.|||
khvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddF

WRMLMEQNSNIIVMLTQLHEGEWEKCYKYWPTDRSARHQYYIVDPIAEHE-----YPQFVIRDFKVKDARS-DTVRNIKQFHFLGWPETGVPKSGegIID
|||. |||..||||.|.| | . .||  |||.| | . .   |  |.|.        ..||...|.|. .. ||.....|.|.  ||..|||..   . .
WrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehs..lpv

LIGQVQRAYEQQEEEGPITVHCSDGVGRTGVFTALFIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYLGS
||  ..... ...| |||.|||| ||||||.. .|  .|.....| .|..|...| .|.||. .||..|||.| ... || . |
LifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias
subfamily_Ptp69D_pd Subfamily Ptp69D 1604-1866 1.6e-81 268.8 In-house 22-286 (307) alignment 
Range on Protein: 1604-1866
Range on HMM: 22-286/307.0
TGLEEEFKVVDPSqAKKHKYGAATLAINRPKNRLANILPYETTRVHISPVRGVEGSDYINASFIDGYRQRGLFIATQGPLQDTVDDFWRMLMEQNSNIIV
 ||..|.. .  .   ...  ..    |  |||  .| ... ||| .... | | ||||||||| ||...  ||| |.|.. |..|||||..||....||
fglakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtliv

MLTQLHEGEWEKCYKYWPTDRSARHQYYIVDPIAEHEYPQFVIRDFKVKDAR-----SDTVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRAYEQQee
||..| | . .|| |||| .   ...  .|... |.. ....||...|          .  |.. |.|..||... ||.. .|...|| ||.  |...  
mlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln..

EGPITVHCSDGVGRTGVFTALFIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYL
..||.|||| ||||.|.| || ..|.... |  ||.|.||| || ||. .||| ||| |.|.  |.| 
rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldys
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1603-1870 2.7e-81 268.0 In-house 21-287 (305) alignment 
Range on Protein: 1603-1870
Range on HMM: 21-287/305.0
VTGLEEEFKVVDPSqAKKHKygAATLAINRPKNRLANILPYETTRVHISPVRGVEGSDYINASFIDGYRQRGLFIATQGPLQDTVDDFWRMLMEQNSNII
 .|||...| .     .. .    .   |. ||||..| .... |.....   .. |||||||..|||...  .|..||||..||.||||...|   . |
dkgleaqykslyee.eesid..vgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvsti

VMLTQLHEGEWEKCYKYWPTDRSA--RHQYYIVDPIAEHEYPQFVIRDFKVKDARS-DTVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRAYEQqEEE
||||.| ||. .||..|||.  .   ... ..|    |........|..|.  ... .  |.. |...  ||. |||..   ...|| .||..... ...
vmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkk.dkg

GPITVHCSDGVGRTGVFTALFIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYLGSFD
 |..||||.|||||||| |. | |||.. |.|||.|. .| ||..|. |||...|| |..    |.. ..|
vpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgd
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1590-1863 4.8e-81 267.0 In-house 7-276 (288) alignment 
Range on Protein: 1590-1863
Range on HMM: 7-276/288.0
HHIKKLTELGKGEVTGLEEEFKVVdPSQAKKHKYGAATLAINRPKNRLANILPYETTRVHISPVRGVEGSDYINASFIDGYRQRGLFIATQGPLQDTVDD
. ..| ..  . . ||..||.... ..  |...  |. || | .|||  |||||. .||..  .  ..|.||||||.|||....  .|||||||.|||.|
spvakvakksarnrtgfseeynsL.aalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvnd

FWRMLMEQNSNIIVMLTQLHEGEWEKCYKYWPTDRS-ARHQYYIVDPIAEHEYPQFVIRDFKVKdaRSDTVRNIKQFHFLGWPETGVPKSGEGIIDLIGQ
||..  |.... |||||.| ||. .|| .|||..    ..    |  . ..|  .|| | . ..  .. | ..|.|...|.||..|||.| . ...|. |
fWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrq

VQRAyeQQEEEGPITVHCSDGVGRTGVFTALFIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTAL
|. |  .|.. |||.||||.||||||.| ||  .......| ..|.. ||. || ||. .|| ..|| |.|.. |
vkva..nqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
0040439 (Phosphotyrosine protein) phosphatases II 1625-1866 7.4e-81 266.7 In-house 5-246 (249) alignment 
Range on Protein: 1625-1866
Range on HMM: 5-246/249.0
AATLAINRPKNRLANILPYETTRVHISPVRGVEGSDYINASFIDGYRQRGLFIATQGPLQDTVDDFWRMLMEQNSNIIVMLTQLHEGEWEKCYKYWPTDR
 | |  |..|||  .||||. .||..|...|...|||||||.||||..   ||||||||..||.|||||| |.....|||||.| | ..|||..|||.. 
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplgg

SARHQYYIVDPIAEHEYPQFVIRDFKVKDARSDTVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRAYEQQEEEGPITVHCSDGVGRTGVFTALFIVLE
|  .  . |  . ..... ...| .....   ...| ........||..|||.| | ..|.| .|. |.|. ...||. ||||.||||||.| |....||
sleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmle

RMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYL
... |. |||...|||||.||| .||..||| |.|. .||.|
qlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1602-1865 2.2e-80 265.4 In-house 32-291 (319) alignment 
Range on Protein: 1602-1865
Range on HMM: 32-291/319.0
EVTGLEEEFKVVDPSQAKKHKYGAATLAINRPKNRLANILPYETTRVHISPVRGVEGSDYINASFIDGYRQRGLFIATQGPLQDTVDDFWRMLMEQNSNI
..| || ||. .    ..  .   | |  |. |||. |||... ..| . .. |.|.||||||||..||...  .||.||||..|..|||||. |.|.  
dltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncst

IVMLTqlhegeWEKCYKYWPTDRSARHQYYIVDPIAEHEYPQFVIRDFKVKD-ARSDTVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRAYEQQEEEG
||.||       .|| .||| .   ... . |.  . .|  ..|.||... . ..   .|.|.||||||||. |||...  .. |. .|.   ...... 
ivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhra

PITVHCSDGVGRTGVFTALFIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALE-Y
.| |||| |||||||. .| ..|.||. |  ||....|. || ||. .||.  || |.| . || .
nivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleeh
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1630-1873 4e-80 263.6 In-house 8-249 (250) alignment 
Range on Protein: 1630-1873
Range on HMM: 8-249/250.0
INRPKNRLANILPYETTRVHISPVRGVEGSDYINASFIDGYRQRGLFIATQGPLQDTVDDFWRMLMEQNSNIIVMLTQLHEGEWEkCYKYWPTDRSARHQ
 |. ||| |.|.... .|| . ...| . ||||||||..||..| .|||||||||.|. |||||..|..|. |||||.|.| | . . .|||.... .. 
qnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaekyG

YYIVDPIAEHEYPQFVIRDFKVKDARSDTVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRAyEQQEEEGPITVHCSDGVGRTGVFTALFIVLERMRSE
   |..  ..|.  ...| .|.  |.    | ..|.||. ||. |||.  . ...|. .||.  .|| ...|. |.|| ||||.| | |.  ||||.. |
dvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqas.qqqagnaPvivqCsaGvgrsGafiaidavlerlkke

GVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYLGSFDHYA
 |||.|. .| ||..|| .|.|.||| |.|. .|..| |.. ||
kvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedya
0042113 (Phosphotyrosine protein) phosphatases II 1626-1866 5.1e-79 260.4 In-house 4-243 (245) alignment 
Range on Protein: 1626-1866
Range on HMM: 4-243/245.0
ATLAINRPKNRLANILPYETTRVHISPVRGVEGSDYINASFIDGYRQRGLFIATQGPLQDTVDDFWRMLMEQNSNIIVMLTQLHEGEWEKCYKYWPTDRS
| |  |..|||  .||||. |||..||. | ..|||||||..||||. . ||||||||..||.|||||| |.....|||||...| ...||..|||.. |
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplges

ARHQYYIVDPIAEHEYPQFVIRDFKVKDARSDTVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRAYEQqEEEGPITVHCSDGVGRTGVFTALFIVLER
 ..  ..|  . |. .. ...| ..|.. ..| .|.. ..|.|.||. ||| . | ..|..  |..|...  ..||. ||||.||||||.| |....||.
ltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfiaaylmleq

MRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYL
...|. |.|...|| || ||| .||...|| |.|. .||.|
lekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
0037934 (Phosphotyrosine protein) phosphatases II 1337-1574 8.6e-79 259.8 In-house 4-240 (243) alignment 
Range on Protein: 1337-1574
Range on HMM: 4-240/243.0
SSQMECNKGKNRYPNIHAYDHSRVRLsyingiEGSDYINANFCDGYRKeraYIATQGPMQHTAAD----FWRMVWEQRTFTIVMLTREEERGRVKCDQYW
 .....|. ||||..| .||||||.|      |||||||||.......   .||||||...| .|    ||||.||... .|||||...|.||.||.|||
iallpenlsknrysdilpydhsrvkl......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PtDGTdVYEGIEVSLVDWVELANYTISTLQICKEG-ASQPREVKHFQFTGWPDHGVPAHPTPFLAFLRRVKFY--------NPPDAGPIVVHCSAGVGRT
| ... .|....| |..  .|..||. ||...  .   ..|.| |.....||||||| .|...|.||. |. .        . .. ||..||||||||||
p.gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRt

GCFIVIDSMLERLrheeTVDIYGHVTVLRTQRNY-MVQTQEQYIFSHDAILE
|..|... ||..|    .||..  |  ||.||.. .|||..||.| ..|.||
Gtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
0045098 (Phosphotyrosine protein) phosphatases II 1630-1867 1.9e-78 258.9 In-house 32-273 (278) alignment 
Range on Protein: 1630-1867
Range on HMM: 32-273/278.0
INRPKNRLANILPYETTRVHispvrgvegsDYINASFIDGYrqRGLFIATQGPLQDTVDDFWRMLMEQNSNIIVMLTQLHEGEWEKCYKYWPTDRSARHQ
 |..|||  .||||. .||.          ||||||.||||  .  ||||||||..||.|||||| |.....|||||.|.|...|||..||| . | .. 
gnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltyg

YYIVDPIAEHEYPQFVIRDFKVKDA----RSDTVRNIKQFHFLGWPETGVPKSG--EGIIDLIGQVQRAYE-----------QQEEEGPITVHCSDGVGR
 . |  . |.... ...|...| .      ... |.....|.|.||. ||| .     ...|. ....|..           .....||. |||| ||||
dftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgR

TGVFTALFIVLERMrsEGVVDLFQTVKLLRTQRPA-MVQSQEQYLFCYKTALEYLG
||.. |....||..  ||.|||...|| ||.|||  .||..||| |.|. .||.| 
tGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1619-1865 2e-78 258.8 In-house 13-255 (284) alignment 
Range on Protein: 1619-1865
Range on HMM: 13-255/284.0
KKHKYGAATLAINRPKNRLANILPYETTRVHISPVRGVEGSDYINASFIDGYRQRGLFIATQGPLQDTVDDFWRMLMEQNSNIIVMLTqlhegeWEKCYK
.  .   | |  |. |||. .||... ..| . .. |.|.||||||||| ||...  .|||||||..|..|||||. |.|.  ||.||       .|| .
ngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsq

YWPTDRSARHQYYIVDPIAEHEYPQFVIRDFKVKD-ARSDTVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRAYEQQEEEGPITVHCSDGVGRTGVFT
||| .   ... . |.  . .|  ..|.||... . ..   .|.|.||||||||. |||...  .. |. .|.   ...... .| |||| |||||||. 
ywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyi

ALFIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALE-Y
.| ..|.||. |  ||....|. || ||. .||.  || |.| . || .
vldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleeh
subfamily_PTPRK_pd Subfamily PTPRK 1585-1864 8.5e-78 256.3 In-house 6-275 (314) alignment 
Range on Protein: 1585-1864
Range on HMM: 6-275/314.0
ARNLLHHIKKLtelGKGEVTGLEEEFKVVDPSqakkhkYGAATLAINRPKNRLANILPYETTRVHISPVRGVEGSDYINASFIDGYRQRGLFIATQGPLQ
. .||..|..|    ..|  |. ||.. .         . ||    || |||  .||.|. .|| . .. |   ||||||..||.|..   ||.||||||
vadllqsiall...kraegygfkeeyeslfeg......wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlq

DTVDDFWRMLMEQNSNIIVMLTQLHEGEWEKCYKYWPTDRSArHQYYIVDPIAEHEYPQFVIRDFKVKD--ARSDTVRNIKQFHFLGWPETGVPKSGEGI
.|| ||||.. ..|.  |||||.| |    ||.|||| | .  ..   |  .  .   ..|.| |.|.      . .| ..||.|||||. .||.| .|.
etvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgl

IDLIGQVQRAYEQqeEEGPITVHCSDGVGRTGVFTALFIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALE
..|. .|.   |.  |.|.| |||| | ||||.| |. |||. .. |||||.|..|| ||.... ||. .||| |.|  .||
lklvrrvkksqee..eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
Y_phosphatase Protein-tyrosine phosphatase 1631-1864 7e-77 253.4 Pfam-A 1-235 (235) alignment 
Range on Protein: 1631-1864
Range on HMM: 1-235/235.0
NRPKNRLANILPYETTRVHIspvRGVEG-SDYINASFIDGYRQRGLFIATQGPLQDTVDDFWRMLMEQNSNIIVMLTQLHEGEWEKCYKYWP--TDRSAR
|. |||  .||||. |||..   .| || ||||||....||..   ||||||||..|..|||||........|||||.| | . ||| .|||  ...| .
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

HQYYIVDPI-AEH-EYPQFVIRDFKVKDARSDT-VRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRAYeqQEEEGPITVHCSDGVGRTGVFTALFIVLE
.. . |     |. .  ....|....|.  ...  | .||.|. .||. |||.| ....||| .|..    ....||..||||.||||||.| || |.||
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldille

RMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALE
....|. ||..|.|| ||.||| |||| ||| |.||. ||
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 1631-1864 7e-77 253.4 In-house 1-235 (235) alignment 
Range on Protein: 1631-1864
Range on HMM: 1-235/235.0
NRPKNRLANILPYETTRVHIspvRGVEG-SDYINASFIDGYRQRGLFIATQGPLQDTVDDFWRMLMEQNSNIIVMLTQLHEGEWEKCYKYWP--TDRSAR
|. |||  .||||. |||..   .| || ||||||....||..   ||||||||..|..|||||........|||||.| | . ||| .|||  ...| .
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

HQYYIVDPI-AEH-EYPQFVIRDFKVKDARSDT-VRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRAYeqQEEEGPITVHCSDGVGRTGVFTALFIVLE
.. . |     |. .  ....|....|.  ...  | .||.|. .||. |||.| ....||| .|..    ....||..||||.||||||.| || |.||
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldille

RMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALE
....|. ||..|.|| ||.||| |||| ||| |.||. ||
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_PTPN6_pd Subfamily PTPN6 1316-1575 4e-76 250.9 In-house 24-296 (306) alignment 
Range on Protein: 1316-1575
Range on HMM: 24-296/306.0
NNSQFTQEYESI---EPGQTFTADSSQMECNKGKNRYPNIHAYDHSRVRLSyINGIEGSDYINANFCDGY--RKERAYIATQGPMQHTAADFWRMVWEQR
... |..|.|..   |  .... . ..   || |||| ||  .||.|| |.  ... ||||||||. ..    ....|||||| ...| .|||||||.. 
ekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqen

TFTIVMLTREEERGRVKCDQYWPTDGTDV-YEGIEVSLVDWVELANYTISTLQIC-KEGASQPREVKHFQFTGWPDHGVPAHPTPFLAFLRRVKFYN---
.  |||.|.| |||. || .|||.  ..  |  |.|. |.  .||.|.. .|... |. ... ||| ...|. |||||||..|  .|.||. |.  .   
srvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeel

-PPDAGPIVVHCSAGVGRTGCFIVIDSMLERLRHE---ETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEA
   .|||||||||||.|||| ||||| .|. ....     .||.  | ..|.||. .|||..|| | . || . 
eeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikky
subfamily_PTPN9_pd Subfamily PTPN9 1603-1866 1.7e-75 248.8 In-house 15-290 (297) alignment 
Range on Protein: 1603-1866
Range on HMM: 15-290/297.0
VTGLEEEFKVVDpSQAKKHKYGAATLAINRPKNRLANILPYETTRVHISPVRGVEGSDYINASFIDGYRQRGLFIATQGPLQDTVDDFWRMLMEQNSNII
  || .|.. .  ... . .. |. |  |  ||| ...| |. |||... | . | ||||||.|.|||.|.  ||||||||. ||.|||||. ||.  .|
krGlskeyaeir.nepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvi

VMLTQLHEGEWEKCYKYWP--TDRSARHQYYIVDPIAEHEYPQFVIRDFKVKDARSDTVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRAY-------
|| |.. |    || .|||  .. ||..  . |  .  .|. ....| ...|... .  |..  | ||.||. |||.|.. ..|.. .|...        
vmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkel

----EQQEEEGPITVHCSDGVGRTGVFTALFIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYL
    . . .. || |||| |.|||| |..| | |.|....|.||...|||||||||  ..| .||| |||.. ||| 
gdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1313-1610 9.4e-75 246.6 In-house 13-311 (515) alignment 
Range on Protein: 1313-1610
Range on HMM: 13-311/515.0
KADNNSQFTQEYESIEPGQTFTADSSQMECNKGKNRYPNIHAYDHSRVRLSYINGIEGSDYINANFCDGYRKERAYIATQGPMQHTAADFWRMVWEQRTF
|. . . |..|.  .   . .    .| | |  |||| ||  || .||.|  ||    |||.|| .  ..  ..||||.||| . .  ||||.|..... 
knrhttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvt

TIVMLTREEERGRVKCDQYWPT-DGTDV-YEGIEVSLVDWVELANYTISTLQICKEGAsqPREVKHFQFTGWPDHGVPAHPTPFLAFLRRVKFYNPPDAG
||.|.|. .|  ..|| .|||   |  | .  |.|.||     .. .. .|.. |.     | |  |.||.|||.||| | . .| ... ||  .   . 
tiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyth

PIVVHCSAGVGRTGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAVSCGNTEVHARNLLHHIKKLTELGKGEVT-GLEEE
|...|||||||||| .| |||.. . .  ..||..  ||..| .| |.||||||| | ..|.|| .   || .    .  |.. |   | |.    . .|
pliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmtke

F
|
f
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1299-1602 1.3e-74 245.8 In-house 2-303 (315) alignment 
Range on Protein: 1299-1602
Range on HMM: 2-303/315.0
PISVLDLPKHIAilKADNNSQFTQEYESIEPGQTFTADSSQMECNKGKNRYPNIHAYDHSRVRLSYINGIEGSDYINANFCDGYRKERAYIATQGPMQHT
|| | ..|  .   |  . . |..|.  .   ...   ... . |  |||| ||  .|..||.|  |. .  |||||| .  .. ...||||.||| . .
pipvaqfpafvn..knrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkas

AADFWRMVWEQRTFTIVMLTREEERGRVKCDQYWPTDGTDV--YEGIEVSLVDWVELANYTISTLqICKEGaSQPREVKHFQFTGWPDHGVPAHPTPFLA
  ||||||..... ||||.|  .|  ..|| ||||   .|   .  |.|.|..    .. ..  | . ...  . | |  ||||.|||.||. . . .| 
vddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrks.eesrtvtqfqftewPdkGvdkqtssllk

FLRRVKFYNPPDAGPIVVHCSAGVGRTGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAVSCGNTEVHARNLLHHIKKLT
... ||  | ..  ...||||||||||| .| ||...........||..  |. ||..| |.|||.|.| | .||.|| .   || .   ..  |.. | 
likevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlh

ELGKGE
  ..|.
tsvdgs
subfamily_PTPN12_pd Subfamily PTPN12 1327-1577 1.3e-74 245.7 In-house 24-278 (290) alignment 
Range on Protein: 1327-1577
Range on HMM: 24-278/290.0
IEPGQTFTADSSQMECNKGKNRYPNIHAYDHSRVRLSYINGIEGSDYINANFCDGYRKERAYIATQGPMQHTAADFWRMVWEQRTFTIVMLTREEERGRV
    ......... | |. |||| .|  ||.||| || |.. ||||||||||  |  .. .|||.|||. .|  |||||.||...  .||. || | |. 
ykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkk

KCDQYWPTD-GTDV-YEGIEVSLVDWVELA-NYTISTLQICKEgaSQPREVKHFQFTGWPDHGVPAHPTPFLAFLRRVKFYNPPDAGPIVVHCSAGVGRT
||..|||   .... .. .||.| .   .  ...| ||.. ..  .. |.|. |..| |||||||. ... |.... |. ..  .. |.|||||||||||
kCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrt

GCFIVIDSMLERLRHEET---VDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAVS
|  |.|| . | |..| .   .|..  |. ||.||. .|||.||| . . |..| |.
Gtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
subfamily_PTPN13_pd Subfamily PTPN13 1320-1576 8e-74 243.3 In-house 13-269 (273) alignment 
Range on Protein: 1320-1576
Range on HMM: 13-269/273.0
FTQEYESIEPG-QTFTADSSQMECNKGKNRYPNIHAYDHSRVRLSYINGiegsdYINANFCDGY--RKERAYIATQGPMQHTAADFWRMVWEQRTFTIVM
 ..|.. ..    . |..... . || |||| |.  ||..||.|.   |     ||||..       .|  |||.|||. .|..|||.|||||..  |.|
PaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviam

LTREEERGRVKCDQYWPTD---GTDVYEGIEVSLVDWVELANYTISTLQICKEGASQPREVKHFQFTGWPDHGVPAHPTPFLAFLRRVKFYNPpDAGPIV
.| | |.|.|||..|||      . |.. .||.|.. ..| ......|.. .  ... ||| |..|. |||||||......| |...|.  .  ||||||
vtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPiv

VHCSAGVGRTGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAV
||||||.||.| .|.|| .|. . ... .|.   |  || ||. .|||..|||| . ||||..
vhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_PTPN6_pd Subfamily PTPN6 1591-1866 9.1e-74 243.2 In-house 15-297 (306) alignment 
Range on Protein: 1591-1866
Range on HMM: 15-297/306.0
HIKKltELGKGEVTGLEEEFKVVDPSQ-AKKHKYGAATLAINRPKNRLANILPYETTRVHISpVRGVEGSDYINASFIDGYR--QRGLFIATQGPLQDTV
...|  |  . | .|.||||. .. ..  |...   .. . |. |||  ||||.. ||| ..   .| |||||||..|..    ..  .||||| |..||
elek..eeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettv

DDFWRMLMEQNSNIIVMLTQLHEGEWEKCYKYWPTDRSARH-QYYIVDPIAEHEYPQFVIRDFKVK-DARSDTVRNIKQFHFLGWPETGVPKSGEGIIDL
 |||||....||..|||.|.  |   |||..|||.  . ..   . |  ..|..  ....|...|.   .... |.. |.||  ||. ||||. . ..|.
sdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdf

IGQVQRAYEQQE--EEGPITVHCSDGVGRTGVFTALFIVLERMRSEGV---VDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYL
. .|.| .|. |  |.||| ||||.|.|||| |  . |.|. ....|.   .|. ..||..|.||  .|| ..|| | ||.  .|.
ledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1320-1574 2.1e-72 238.5 In-house 7-266 (274) alignment 
Range on Protein: 1320-1574
Range on HMM: 7-266/274.0
FTQEYESIePgQTFTADSSQMECNKGKNRYPNIHAYDHSRVRLSYINGIEG-SDYINANFCDGYR-KERAYIATQGPMQHTAADFWRMVWEQRTFTIVML
...|. .. |   |. .  ..  .. |||| .|   ..||| |.  .. .  |.|||||.  ||. ...||.|||||...| ||||||......  ||||
lekeflel.P.lnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivml

TREEERGRVKCDQYWPTDG----TDVYEGIEVSLVDWVELANYTISTLQICKEGAsqPREVKHFQFTGWPDHGVPAHPTPFLAFLRRVKFYNP---PDAG
|. .|. . || .|.|..     .. |...|.  .. ||  .|.. .| . .     .|.|||. .| |||| .| .....| ... |.  .      ..
tklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenakla

PIVVHCSAGVGRTGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILE
|.|||||||.||||||| |.  . .||.|..||. . |. || .|  ||||.||| . | |. .
pvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl
subfamily_PTPN12_pd Subfamily PTPN12 1623-1866 1.4e-70 232.5 In-house 32-277 (290) alignment 
Range on Protein: 1623-1866
Range on HMM: 32-277/290.0
YGAATLAINRPKNRLANILPYETTRVHISPVRGVEGSDYINASFIDGYRQRGLFIATQGPLQDTVDDFWRMLMEQNSNIIVMLTQLHEGEWEKCYKYWPT
  |..   |. |||  .||||...||..|  ...||||||||.|| |  ..  .||.|||| .|.||||||..|.| .|.||. .. | .  || .||| 
teagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpe

DRSARH--QYYIVDPIAEHEYP-QFVIRDFKVKDArsDTVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRAYEqqEEEGPITVHCSDGVGRTGVFTAL
    .   . . |. ..|.    .|.|| .||.    .. |...|||.  ||. |||.| . ...|| .|..  |  .|. |. |||| ||||||.  |.
egeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..sedaPlvvhCsaGvGrtGtiiai

FIVLERMRSEGV---VDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYL
 .| | ...| .   .|.|. |  ||.||.|.||..||| . ||. .|..
dyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1307-1584 1.6e-70 232.7 In-house 9-287 (439) alignment 
Range on Protein: 1307-1584
Range on HMM: 9-287/439.0
KHIAILKADNNSQFTQEYESIE---PGQTFTADSSQMECNKGKNRYPNIHAYDHSRVRLSYINGIEGSDYINANFCDGYRKERAYIATQGPMQHTAADFW
.|.  |. ...  |....|.|.   |  .  |     | .. |||| .. |.||.|| |  | |.  | |||||. .|| ... ||||||| ..|. |||
ehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfw

RMVWEQRTFTIVMLTREEERGRvkcdqYWPTDGTDVYEGIEVSLVDWVELANYTISTLQICKEG--ASQPREVKHFQFTGWPDHGVPAHPTPFLAFLRRV
|.|.|..| ||||||   |  .     |||.|.  .|  | |     .|| ||.|  ... .|   . . | | .|... |||. |||. .  | ||| .
rlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrai

KFYNP-PDAGPIVVHCSAGVGRTGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAVSCGNTEVH
.  |   . ||.||||||||||||  | .|  ||.|. |. ||| | |.||| ||. |||.  ||.| ..|.|| .  |.. | 
nsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavt
0037934 (Phosphotyrosine protein) phosphatases II 1626-1866 1.6e-70 232.7 In-house 5-242 (243) alignment 
Range on Protein: 1626-1866
Range on HMM: 5-242/243.0
ATLAINRPKNRLANILPYETTRVHIspvrgvEGSDYINASFIDGYRQrglFIATQGPLQDTVDD----FWRMLMEQNSNIIVMLTQLHEGEWEKCYKYWP
| |  |..|||  .||||. .||..      ||||||||..|.....   .|||||||..||.|    ||||| |.....|||||.| | ..|||..|||
allpenlsknrysdilpydhsrvkl......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

tdRSARHQYYIVDPIAEHEYPQFVIRDFKVKDAR-SDTVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRAYEQ------QEEEGPITVHCSDGVGRTG
   . ..  ..|  . |........| ....    .| .|.. ..|.|.||. ||| | | ..|.. .|.  .|.        ..||. |||| ||||||
..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtG

VFTALFIVLERMrseGvVDLFQTVKLLRTQRPA-MVQSQEQYLFCYKTALEYL
.. |....|...   | |||...|||||.|||  .||...|| |.|. .||.|
tliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1604-1872 4.8e-70 230.7 In-house 20-289 (290) alignment 
Range on Protein: 1604-1872
Range on HMM: 20-289/290.0
TGLEEEFKVVDPsQAKKHKYGAATLAINRPKNRLANILPYETTRVHISPVRGVEG--SDYINASFIDGYRQRGLFIATQGPLQDTVDDFWRMLMEQNSNI
.| ...||..|   ...|.   ..   |...|| |||..|.  |. . |. | .    .||||..|.||...  .||||||...|. |||........ |
egfrnqfkmlds.gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvti

IVMLTQLHEGEWEKCYKYWPTDRSARHQYYIVDPIAEHEYPQFVIRDFKVKDARS-DTVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRAyEQQEEEG
|||||.  | . .||..|||.  ... ... .  . |... ....| ..||. .| .. ....|...  |..||  .  ..|. .| ....  . .. ..
ivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemykt.qrkrgnt

PITVHCSDGVGRTGVFTALFIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYLGSFDHY
.| |||||.|||..|| |. . ......|||.|.|| .| .|.|.| .||...|| . ..  |.|| ||. |
sivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1603-1873 7.7e-70 230.1 In-house 19-285 (287) alignment 
Range on Protein: 1603-1873
Range on HMM: 19-285/287.0
VTGLEEEFKVVDPSQAKKHKYGAATLAINRPKNRLANILPYETTRVHISpvrgVEGSDYINASFIDGYRQRGLFIATQGPLQDTVDDFWRMLMEQNSNII
 .| .. |.|..  . ....   .    |..||||..||...  || .      |  |||||.|||||...  ||....|. .|. .||... ..| ..|
negfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtai

VMLTQLHEGEWEKCYKYWPTDRSARHQYYIVDPIAEHEYPQFVIRDFKVKDARS-DTVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRAyEQQEEEGP
|||.|..| . |.||.|||...|     | .  . |. . ....|...||   . .. ...||...  |..||  .. . |. .| .  .. .... ...
vmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemykt.qrkrgnts

ITVHCSDGVGRTGVFTALFIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYLGSFDHYA
| |||||.|||...| |  . ... . |||.|.|| .|  | |.| .||  ||| | ..  |||| ||. |.
ivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetys
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1303-1580 5.3e-69 227.3 In-house 5-287 (290) alignment 
Range on Protein: 1303-1580
Range on HMM: 5-287/290.0
LDLPKHIAILKADNNSQFTQEYESIEPGQ-TFTADSSQMECNKGKNRYPNIHAYDHSRVRLSYINGIEG--SDYINANFCDGYRKERAYIATQGPMQHTA
 .. ...|  .| .|..| ....... |.  .|.     . || .||. ||  ||  |. |  |.| .    .|||| . .||.....|||||||...|.
dkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntl

ADFWRMVWEQRTFTIVMLTREEERGRVKCDQYWPTDGTDVYEGIEVSLVDWVELANYTISTLQICKEGA-SQPREVKHFQFTGWPDHG-VPAHPTPFLAF
.|||...|....  ||||| . | |.||| ||||. .|. |. ... |..  .| .|.. .|.. .. .  ....|...|.| |...| |... |  |..
vdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvi

LRRVKFYNPPDAGPIVVHCSAGVGRTGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAVSCGN
 ...|    .  ..||||||..|||.. |....  ... . |  .|..  .  .|.|.  .|||..|| . .. .|..... .
eemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfe
subfamily_PTPN3_pd Subfamily PTPN3 1333-1576 6.6e-69 226.9 In-house 31-275 (280) alignment 
Range on Protein: 1333-1576
Range on HMM: 31-275/280.0
FTADSSQMECNKGKNRYPNIHAYDHSRVRLSYINgiEgsDYINANFCD----GYRKERAYIATQGPMQHTAADFWRMVWEQRTFTIVMLTREEERGRVKC
 . . ...  |  |||| .| .||. ||.|.  .     ||||||. .    .      |||||||...||.|||.|||||.. .|||||   |||||||
laisaarkpenlsknryrdilpydatrvklkese..t..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkC

DQYWPTDGT-DVYEGIEVSLVDWVELANYTISTLQICKEGASQPREVKHFQFTGWPDHGVPAHPTPFLAFLRRVKFYNPPDAGPIVVHCSAGVGRTGCFI
 ||||. .    | ...| .    |  .| .  | .... ... |.. ..|.. ||||||| ... || |..||. .   .  |.|||||||.|||| .|
hqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvli

VIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAV
...  |  . ..| | .   |  .| ||  .|||..|| |  .|||.. 
lletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvy
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1307-1585 3.6e-68 224.8 In-house 14-293 (297) alignment 
Range on Protein: 1307-1585
Range on HMM: 14-293/297.0
KHIAILKADNNSQFTQEYESIEPGQ-TFTADSSQMECNKGKNRYPNIHAYDHSRVRLSYINGIEGSDYINANFCDGYRKerAYIATQGPMQHTAADFWRM
.  .... . .... .|     |   ....  ..   |  |.|| ||  || |||.|  .|    |||.|| |  |...   .|.|| ||. | ||||.|
dfatlvqknrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWam

VWEQRTFTIVMLTREEERGRvKCDQYWPTDGTDVYEGIEVSLVDWVELANYTISTLQICKEGASQPREVKHFQFTGWPDHGVPA--HPTPFLAFLRRVK-
|..... |||||. ..|| . || .||. .|.  .  . | |    |   .   .|.. |. | . | || .||. |||. |.   . . .| ..  |. 
vldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrk

FYNPPDAGPIVVHCSAGVGRTGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAVSCGNTEVHA
 ..    ||..|||.||||||| .. |||.. . ..|..|||.| |. || .| |.|||.||| | . |.|||... .|...|
dfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqa
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1616-1870 8.8e-68 223.6 In-house 36-288 (297) alignment 
Range on Protein: 1616-1870
Range on HMM: 36-288/297.0
SQAKKHKYGAATLAINRPKNRLANILPYETTRVHISPVRGVEGSDYINASFIDGYRQRglFIATQGPLQDTVDDFWRMLMEQNSNIIVMLTQLHEGEWeK
 .|. ..   |   .| .|.| .|||||.. ||..  |     |||.||||. |...|  .|.|| | ..||.|||.|..... ..||||....|..  |
peaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkhr..littqmPmkatvadfWamvldeqvstivmlnddnerdk.k

CYKYWPTDRSARHQYYIVDPIAEHEYPQFVIRDFKVKDARSDTVRNIKQFHFLGWPETGVPK--SGEGIIDLIGQVQRAYEQQEEEgPITVHCSDGVGRT
| .||. . ..   .  |   . .|   |. |...|.  .. . | .||..|. ||.  |..  | . ...|| .|.  ..|..|  |. |||. |||||
caryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg.PllvhclaGvGrt

GVFTALFIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYLGSFD
||. ..  |. ... |  ||.|..|| || .|| .|| .||| | |.. ||.| | |
gvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsed
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1595-1866 9.6e-68 223.3 In-house 6-276 (281) alignment 
Range on Protein: 1595-1866
Range on HMM: 6-276/281.0
LTELGKGEVTGLEEEFKVVDPSQAKKHkYGAATLAINRPKNRLANILPYETTRVHISPVRGVEGSDYINASFIDGYRQRGLFIATQGPLQDTVDDFWRML
| .| . . .|. ||.. .   . ..    |..   |. |||  ||  |. |||...|    . .|||||.|..||..   .||||||. .....||.|.
lkqlsqndnaGfieeyeklaaigvdnt.ataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmv

MEQNSNIIVMLTQLHEGEWEKCYKYWPTDR-SARHQYYIVDPIAEHEYPQFVIRDFKVkDARSDTVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRAY
.||. ..|||.|.  |..  ||..||| |. . .   ..|  .||.| .... | ||. ...|   |...|.... ||..|||.. . ...   .|... 
weqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlklt

EQQEEeGPITVHCSDGVGRTGVFTALFIVLERMRSE-GVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYL
|....  |. .||| ||||||.. ||  ..... .|   .|. ..|. || .|  |||.  || | ||. |..|
ekktk.aplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1300-1592 3.2e-67 222.0 In-house 5-304 (325) alignment 
Range on Protein: 1300-1592
Range on HMM: 5-304/325.0
ISVLDLPKHIAILKADNNSQFTQEYESIEPGQTFTADSSQMECNKGKNRYPNIHAYDHSRVRLSYINGIEGSDYINANFCDGYRKERAYIATQGPMQHTA
|.|..| .|.   ||...  |..|.. . . .. .   .    || |||..|. |.|.||| |   .    ||||||..   ..|   ..|.| |. .| 
iavvnlvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltati

ADFWRMVWEQRtFTIVMLTREEERGRVKCDQYWPTD--GTDVYEGIEVSLVDWVELANYTISTLQICKEGASQPREVKHFQFTGWPDHGVPAHPTPFLAF
 |.||.| . |  ..|... | . |  .| .||| .   .  . |.||.|.   |...|    |.. .    . | || ||. .|.| ||. .|. ....
ndlWrlvldWr.csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisi

LRRVKFY------NPPDAGPIVVHCSAGVGRTGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAVSCGNTEVHARNLLHH
|. ||        |   ..||.||||||||||| || . |.|... .|  |||.| |  || .|  ||.| .|||. ..|. ||. .|||.|   ..  .
lqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeak

I
.
l
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1313-1583 3.6e-67 221.4 In-house 15-285 (287) alignment 
Range on Protein: 1313-1583
Range on HMM: 15-285/287.0
KADNNSQFTQEYESIEP-GQTF-TADSSQMECNKGKNRYPNIHAYDHSRVRLSyingIEGSDYINANFCDGYRKERAYIATQGPMQHTAADFWRMVWEQR
.| .| .|.. .  .|  .|.      .  . || |||. .|  .|  || |      |  ||||| | |||....|.|....|| .|| .||.......
hakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrn

TFTIVMLTREEERGRVKCDQYWPTDGTDVYEGIEVSLVDWVELANYTISTLQICKEG-ASQPREVKHFQFTGWPDHG-VPAHPTPFLAFLRRVKFYNPPD
  .||||..|.|  . .| ||||.. . |.   ...|..    |.|.. .|.. ... |.....|| .|.| |...| |. . | .| . ...|    . 
vtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrg

AGPIVVHCSAGVGRTGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAVSCGNTEV
 ..||||||..|||.. |. ..  ... . | ..|..  .   | |.  .||| |||.|  |..|| .....| .
ntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetys
subfamily_PTPN1_pd Subfamily PTPN1 1318-1578 4.1e-67 220.9 In-house 6-273 (290) alignment 
Range on Protein: 1318-1578
Range on HMM: 6-273/290.0
SQFTQEYESIEPG-QTFTADSSQMECNKGKNRYPNIHAYDHSRVRLSYINGiegsDYINANFCDGYRKERAYIATQGPMQHTAADFWRMVWEQRTFTIVM
 .... |. |.   . |.. ..... |...||| ... |||||..|   .     |||||.. .  . .| || ||||. .|.. ||.|||||.. ..||
rlykeiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvm

LTREEERGRVKCDQYWPTDGT--D-VYE--GIEVSLVDWVELANYTISTLQICKEGASQPREVKHFQFTGWPDHGVPAHPTPFLAFLRRVKFY--NPPDA
| .  |....|| ||||..      ..|   ..| |.   .  .||...|.. .  . . ||. || .| ||| |||  |. || || .|.      .| 
lnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdv

GPIVVHCSAGVGRTGCFIVIDSMLERLRHEET---VDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAVSC
|| |.|||||.||.| |...|..| .. ...    |||  ..  || .|  ..||..|  ||. |||| . .
GpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakv
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1341-1575 1.3e-66 219.2 In-house 5-239 (239) alignment 
Range on Protein: 1341-1575
Range on HMM: 5-239/239.0
ECNKGKNRYPNIHAYDHSRVRLSYINGIEGSDYINANFCDGYR-KERAYIATQGPMQHTAADFWRMVWEQRTFTIVMLTREEERGRVKCDQYWPtDGTDV
  || |||| || .|||||| |  ..    ||||||..   |    .||||||| .. .. |||||.|..|   |||||   |  . || |||| | |  
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.dstsk

YEGIEVSLVDWVELANYTISTLQICKEGASQPREVKHFQFTGWPDHGVPAHPTPFLAFLRRVKFYNPPDAGPIVVHCSAGVGRTGCFIVIDSMLERLRHE
|  . |.|     .|.| | |. . . | .. | | ...|| |||.||| . |  | . |..   . | | | |.||||||||||.|.|||.|| . ...
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkq

ETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEA
.||||. .|  .| .| .|||| |||.| | |.|||
ktvdifnyvkairedrphmvqtseqyvfihlavlea
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1340-1574 4.2e-66 217.5 In-house 5-239 (239) alignment 
Range on Protein: 1340-1574
Range on HMM: 5-239/239.0
MECNKGKNRYPNIHAYDHSRVRLSYINGIEGSDYINANFCDGYR-KERAYIATQGPMQHTAADFWRMVWEQRTFTIVMLTREEERGRVKCDQYWPtDGTD
   || |||| || .|||||| |  ..    ||||||..   |    .||||||| .. .. |||||.|..|   |||||   |  . || |||| | | 
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.dsts

VYEGIEVSLVDWVELANYTISTLQICKEGASQPREVKHFQFTGWPDHGVPAHPTPFLAFLRRVKFYNPPDAGPIVVHCSAGVGRTGCFIVIDSMLERLRH
 |  . |.|     .|.| | |. . . | .. | | ...|| |||.||| . |  | . |..   . | | | |.||||||||||.|.|||.|| . ..
kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakk

EETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILE
..||||. .|  .| .| .|||| |||.| | |.||
qktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1625-1866 9.2e-66 217.0 In-house 37-276 (515) alignment 
Range on Protein: 1625-1866
Range on HMM: 37-276/515.0
AATLAINRPKNRLANILPYETTRVHISPVRGVEGSDYINASFIDGYRQRGLFIATQGPLQDTVDDFWRMLMEQNSNIIVMLTQLHEGEWEKCYKYWPT--
 |   || .|||  |||||...|| .  .     |||.|||.| ..     .||.|||.. .||||||.....|   |.|.|.|.||.  || ||||   
vaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkp

DRSARHQYYIVDPIAEHEYPQFVIRDFKVkdARSDTVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRAYEQQEeeGPITVHCSDGVGRTGVFTALFIV
  | .  .. |. .. .   . ..| ..|   ..| .| . |||| .||. ||||    .. || .|.   .| .   |. .||| |||||||. ..  |
gdsvkfGsikvelvsleactggikrkltv..lkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt..hpliihcsaGvGrtGvvisidsv

LERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYL
. ...   .||.|..|. .| .|| .|| |||| | | . ||.|
vahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1621-1866 9.9e-66 216.7 In-house 34-277 (315) alignment 
Range on Protein: 1621-1866
Range on HMM: 34-277/315.0
HKYGAATLAINRPKNRLANILPYETTRVHISPVRGVEGSDYINASFIDGYRQRGLFIATQGPLQDTVDDFWRMLMEQNSNIIVMLTQLHEGEWEKCYKYW
..  .|   || .|||  ||||....|| .  .     |||||||.| .. .   .||.||||. .|||||||.....   |||.|...||.  || .||
yrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqyw

PT--DRSARHQYYIVDPIAEHEYPQFVIRDFkvKDARSDTVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRAyeQQEEEGPITVHCSDGVGRTGVFTA
|     |..   . |. .  .   . |.| .     .|.. |.. ||.| .||. ||.|    .. || .|.    ....| .. |||| |||||||...
PdrkadsvefGsikvellsleadtdgvarkl..vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad..ngkkefsllvhcsaGvGrtGvvis

LFIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYL
.  |..... . .||.|..|| ||..|| .||..|.| | | . ||.|
idevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledl
subfamily_PTPN13_pd Subfamily PTPN13 1625-1868 2.9e-64 212.0 In-house 31-271 (273) alignment 
Range on Protein: 1625-1868
Range on HMM: 31-271/273.0
AATLAINRPKNRLANILPYETTRVHISPVRGvegsdYINASFIDGY--RQRGLFIATQGPLQDTVDDFWRMLMEQNSNIIVMLTQLHEGEWEKCYKYWPT
 .  . |. |||  |.|||. |||...   |     |||||.|      ..  .||.|||| .||.|||.|. ||....|.|.|.  |..  || .||| 
vgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPe

DRSARHQYYI---VDPIAEHEYPQFVIRDFKVKDARSDTVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRAYEqqeEEGPITVHCSDGVGRTGVFTAL
 .. . . .    |. .   .. .||.|...||| .|  .|.. ...|  ||. |||.| . .. .. .|.|  .   ..||| |||| |.||.|.. ..
sknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt...dagPivvhcsaGiGrsGtliti

FIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYLGS
 .||. .  .  .|. ..|. || || ..||...||.|.||..|| |.|
dvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlks
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1587-1866 5.5e-64 211.3 In-house 9-288 (325) alignment 
Range on Protein: 1587-1866
Range on HMM: 9-288/325.0
NLLHHIKKLTElgkGEVTGLEEEFKVVDPSQAKKHKygAATLAINRPKNRLANILPYETTRVHISPVRGVEGSDYINASFIDGYRQRGLFIATQGPLQDT
||..|..|       .  |.  ||... . ... .|  .|..  |. |||. |..... .|| .   .    |||||||..  ....  |.|.| || .|
nlvehvekkka...qdqdgfahefgllpsddgiakk..vamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltat

VDDFWRMLMEQNSNIIVMLTQLHEGEwEKCYKYWPTD--RSARHQYYIVDPIAEHEYPQFVIRDFKVKDARSDTVRNIKQFHFLGWPETGVPKSGEGIID
..|.||.... .. ..|.| .| .|. ..| .||| .   | .     |  ..  |.  .| | ..||...    | .|||.. .|.. ||.|    .| 
indlWrlvldWrcsvvvvlneldlgk.drcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlis

LIGQVQRAYEQQE----EEGPITVHCSDGVGRTGVFTALFIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYL
..  |.   |.        .|| ||||.|||||||| .|. .|...  |  ||.|. || || .||.||.. .|| ..|..  |..
ilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_PTPN23_pd Subfamily PTPN23 1599-1865 7.6e-64 210.3 In-house 10-279 (288) alignment 
Range on Protein: 1599-1865
Range on HMM: 10-279/288.0
GKGEVTGLEEEFKVVDPSQAKKHKYGAATLA-INRPKNRLANILPYETTRVHISpvrgVEGSDYINASFIDGYRQR-GLFIATQGPLQDTVDDFWRMLME
  ...|.|...|| .. .|.|. .  . ..| ..  |||  .||||. .||..      .  |||||||. .       |||||.||| |. |||.|..|
mldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvye

QNSNIIVMLTQLHEGEWEKCYKYWPTDRSA--RHQYYIVDPIAEHEYPQFVIRDFKVKDARSDTVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRAYE
| |..||||.. .| . .|. .|||.|. .  ... . |    ..| ...| |..|..  ..|.|....  ..  ||| |||.| | .......|. |||
qkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesaye

Q--QEEEGPITVHCSDGVGRTGVFTALFIVLERM-RSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEY
.  .. . |. |||| ||||||||. .. ... . . .|..|. | |. ||.||  ||| .||. |.|.  ||.
avqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1619-1865 7.7e-64 210.6 In-house 37-278 (315) alignment 
Range on Protein: 1619-1865
Range on HMM: 37-278/315.0
KKHKYGAATLAINRPKNRLANILPYETTRVHISPVRGVEGSDYINASFIDGYRQRGLFIATQGPLQDTVDDFWRMLMEQNSNIIVMLTQLHEGEWEKCYK
. |    |    |. |||  ||..|. .||..  .   ..|||.||.||||| ..  .||.|||.  .|.||||...|..   |||||.| ||| .|. |
qlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaek

YWPTDrSARHQYYIVDPIAEHEYPQFVIRDFKVkdARSDTVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRAYEQQEeeGPITVHCSDGVGRTGVFTA
||| .    .  . |  . |  . .. .| . |     | .|.. |.|.  ||..||||.   ...|| .|..  ...   |.| ||||.|||||| | .
ywpdk.kviyGkitvtrkseevnteytvrtlsv..vfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv..gaivvhcsaGvGrtGtfit

LFIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEY
|  ||...  | ..|... .. .| .|  |||. ||| | |.. || 
ldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydallet
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1343-1574 3.1e-63 208.2 In-house 3-237 (237) alignment 
Range on Protein: 1343-1574
Range on HMM: 3-237/237.0
NKGKNRYPNIHAYDHSRVRLSYINGieGSDYINANFCDGYR-KERAYIATQGPMQHTAADFWRMVWEQRTFTIVMLTREEERGRVKCDQYWP-TDGTDVY
|| |||| || ||||||| |    .  |||||||.. .|.    . |||.|||.. .  |||.|||...   |||||   |. ..|| .||| ||    |
nkiknrygnivaydhsrvvlkgags..gsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

EGIEVSLVDWVELANYTISTLQICKEGASQ-PREVKHFQFTGWPDHGVPAHPTPFLAFLRRVKFYNP--PDAGPIVVHCSAGVGRTGCFIVIDSMLERLR
  . |||    |...||. .| . |..  .  | .. .||| |||.||| . . .| | ...   .|  ...|| ..|||||||||| |.|||.|| . .
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

HEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILE
 .. |||| .|  .  .| |..||..||.| |..|||
ekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1627-1867 2.3e-62 205.6 In-house 24-269 (274) alignment 
Range on Protein: 1627-1867
Range on HMM: 24-269/274.0
TLAINRPKNRLANILPYETTRVHISPVRGVEG-SDYINASFIDGYRQ-RGLFIATQGPLQDTVDDFWRMLMEQNSNIIVMLTQLHEGEWEKCYKYWPTDR
... .  |||  .||| |..|| ...  . .  |.|||| .| ||..    ..||||||. ||.|||||. ......|||||.|.| . .|| .|.|...
dvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdae

SA----RHQYYIVDPIAEHEYPQFVIRDFKVKDARSdtVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRAYEQQEEE-GPITVHCSDGVGRTGVFTAL
..    |..   .      |  .. .| . .| . .   |..| . .  ||.. .|.. . ..||. .|... |..... .|. |||| |.||||.|.| 
dyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiai

FIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYLG
 | . ..| |.|||....|  || .|  |||..||| . ...  .|| 
siavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_PTPN23_pd Subfamily PTPN23 1315-1576 2.6e-62 205.2 In-house 12-280 (288) alignment 
Range on Protein: 1315-1576
Range on HMM: 12-280/288.0
DNNSQFTQEYESIEPGQTFTADS---SQMECNKGKNRYPNIHAYDHSRVRLSyingIEGSDYINANFCDGYRKE-RAYIATQGPMQHTAADFWRMVWEQR
|..... .... .|  |   | .   .  ...  |||. .|  |||.|| |      .  ||||| |  .       .||||.|.| |..|||.||.||.
dgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqk

TFTIVMLTREEERGRVKCDQYWPTD--GTDVYEGIEVSLVDWVELANYTISTLQICKEGASQPREVKHFQFTGWPDHGVPAHPTPFLAFLRRVKF-Y---
. .||||. .||.|. |.|.|||.|   | ... ..|.| .  |. ..   .|..  ..|.. ..|.| |.| ||..|||| |  .|.||  |.  |   
ssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeav

NPPDAGPIVVHCSAGVGRTGCFIVIDSMLERLRHEE-TVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAV
. .   |.|||||||||||| | .. . .. |....  .||   |  ||.|| .|||..||. || .|.|||.
qrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa
subfamily_CG7180_pd Subfamily CG7180 1629-1866 5.2e-62 204.2 In-house 40-290 (296) alignment 
Range on Protein: 1629-1866
Range on HMM: 40-290/296.0
AINRPKNRLANILPYETTRVHISPVRGVEGSDYINASFIDGYRQRGLFIATQGPLQDTVDDFWRMLMEQNSNIIVMLTQLHEGEWeKCYKYWPTDRSARH
. || |||  ...||. .|| .. . | | ||||||...|.. .   .| |..| ..|||.|||.. ..... .|.||.  . .  .. .||| .  ...
kenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqy

QYYIVDPIAEHEYPQFVIRDFKVKDA----------RSDTVRNIKQFHFLGWPE-TGVPKSGEGIIDLIGQVQRAYEQQ---EEEGPITVHCSDGVGRTG
.  .|. . |..|....|| ||..             .  .| .|.|..  |.    || | ...|.|. .|.   |.    .||||. |..|||..|.|
geifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsG

VFTALFIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYL
|. |. . || .. |. ||.|. || || .|| .|.. |.| ..| . ||..
vylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_PTPN14_pd Subfamily PTPN14 1316-1574 1.2e-61 203.3 In-house 21-294 (300) alignment 
Range on Protein: 1316-1574
Range on HMM: 21-294/300.0
NNSQFTQEYESIEPGQTF-TADSSQMECNKGKNRYPNIHAYDHSRVRLSYINGIeGSDYINANFCDG--YRKERAYIATQGPMQHTAADFWRMVWEQRTF
....  .||| | . ..  . ...... |. |||....  |...||.||  .    ..||||         ||| ||..|||...|  |||.||||| . 
eegkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvq

TIVMLTREEERGRVKCDQYWPTDG----TDVYEGIEVSLVDWVELANYTISTLQICKEGASQPREVKHFQFTGWPDHGVPAHPTPFLAFLRRVKFY----
 |||||.||| |. |. .|.| ..    |  ..  .|.     .   .. ..|..    ... |.| |.|.| |||||||  ...|| .|..|.      
livmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrkt

-NPP----DAGPIVVHCSAGVGRTGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILE
 .         |..|||||||||||  |. | ... | |.|..||   .. ||.|| ..|||  || | ......
nseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlik
subfamily_CG7180_pd Subfamily CG7180 1340-1580 5.3e-61 200.8 In-house 39-294 (296) alignment 
Range on Protein: 1340-1580
Range on HMM: 39-294/296.0
MECNKGKNRYPNIHAYDHSRVRLSYINGIEGSDYINANFCDGYRKERAYIATQGPMQHTAADFWRMVWEQRTFTIVMLTREEERGRvKCDQYWPTDGTDV
 . |..|||....  ||. || |. ..| | |||||| . |.. |...|| |..|...|  .|||.|... . ..|.||.. .  . .. .||| ..   
rkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeq

YEGIEVSLVDWVELANYTISTLQICKE----------GASQPREVKHFQFTGWPD-HGVPAHPTPFLAFLRRVKFYN-----PPDAGPIVVHCSAGVGRT
|  |.| .|   ..|| .| |... |.             . | ||.||.| |.  . ||   . .. ..|||. .       |. ||.||..| |..|.
ygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRs

GCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAVSCGN
| .. ||  || ...|| ||... |  || .|. .|.. |.| .  | .|||| |. 
GvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1335-1575 5.5e-61 200.9 In-house 12-263 (270) alignment 
Range on Protein: 1335-1575
Range on HMM: 12-263/270.0
ADSSQMECNKGKNRYPNIHAYDHSRVRLSYINGIEGSDYINANFCDGYRK-ERAYIATQGPMQHTAADFWRMVWEQRTFTIVMLTREEERGRVKCDQYWP
 |  ..  .|  ||| .|    ..||||. ..  . . |||||.  |. . ...|||..||.. |  .||||.||... .|||.|  ||.|| ||..|||
sdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWp

TDGTD--V--YEGIEVSLVDWVELANYTISTLQICKEGASqpREVKHFQFTGWPDHGVPAHPT------PFLAFLRRVK-FYNPP-DAGPIVVHCSAGVG
..  .     .  |.|  .  .    | .  |.. ..| .  |.. ||... ||||||| ..         |. || |. . .   .|.|..||||||||
aepkekvkledgkikvlalseekeegyiltrlrleekgee..rrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvg

RTGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEA
|||..|..| ... | ... ||.   .. || .|  .||. ||| | . |..| 
RtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavvey
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1598-1866 6.5e-61 201.1 In-house 14-279 (439) alignment 
Range on Protein: 1598-1866
Range on HMM: 14-279/439.0
LGKGEVTGLEEEFKVVDPSQAK-KHKYGAATLAINRPKNRLANILPYETTRVHISPVRGVEGSDYINASFIDGYRQRGLFIATQGPLQDTVDDFWRMLME
| | .   ..|.|. ..  . . . .   |.   ...|||  .. ... ||| .  . ||  | |||| .|.|| .  |.|||||| ..|.|||||...|
ldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlvie

QNSNIIVMLTQLHEgewekCYKYWPTDRSARHQYYIVDPIAEHEYPQFVIRDFKVKDARSD--TVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRAYE
...  |||||.| |      |||||.|  . .   .|    . | |..||| ||| . |      | . |||.. ||.  ||     ..|..  .. | .
kktvtivmltnlve.....sykywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsand

qQEEEGPITVHCSDGVGRTGVFTALFIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYL
 .|| ||. |||| ||||||   || | ||....|  ||.   ||.|| ||  |||.  ||.| |.. || .
.keeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
subfamily_PTPRN_pd Subfamily PTPRN 1317-1576 1e-60 200.0 In-house 28-292 (297) alignment 
Range on Protein: 1317-1576
Range on HMM: 28-292/297.0
NSQFTQEYESIEPG--QTFTADSSQMECNKGKNRYPNIHAYDHSRVRLSYINGIEGSDYINANF-CDGYRKERAYIATQGPMQHTAADFWRMVWEQRTFT
.... .|.|..     .  |.. .. | |  |||. .. .||||||.|.  .  | |||||| .  |   .. ||||||||. .| ||||.||||| .  
kdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvv

IVMLTREEERGRVKCDQYWPTDGTDVYEGIEVSLVD-WVELANYTISTLQICKEGASQPREVKHFQFTGWPDHGVPAHPTPFLAFLRRVKFYNPPDAGPI
||.||| || |  .|..||| .|..||.  || ||   .   .| . .. .    .|. | |  | |  ||..|||| . ..| | |.|       . ||
ivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpi

VVHCSAGVGRTGCFIVIDSMLERLRH-EETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAV
|||||.|.||||..|.|| .|.|| .    .||   .  || ||. .|.|..|. |   |. | |
vvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev
subfamily_PTPRN_pd Subfamily PTPRN 1605-1862 2.3e-60 198.8 In-house 30-288 (297) alignment 
Range on Protein: 1605-1862
Range on HMM: 30-288/297.0
GLEEEFKVVDPSQAKKHKYGAATLAINRPKNRLANILPYETTRVHISPVRGVEGSDYINASFIDGY-RQRGLFIATQGPLQDTVDDFWRMLMEQNSNIIV
 ||.|.. .   .|...   .|    |  ||| ...|||. .||...     | |||||||.|     ..  .||||||| .|| |||.|. || . .||
rlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvviv

MLTQLHEGEWEKCYKYWPTDRSARHQYYIVDPIAEHEYP-QFVIRDFKVKDARSDTVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRAYEQqeEEGPI
.||.|.| . ..|..||| . |. .. | |. ..|| .  ....| | .|. ...  | . ||||| |||.||| |   ....  .|...|       ||
nltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG..rscpi

TVHCSDGVGRTGVFTALFIVLERMR-SEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTA
 ||||||.|||||. .. .||.|.      .|.  |.. || ||| .|....|. |.... 
vvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltav
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1299-1605 6.7e-60 197.5 In-house 3-265 (392) alignment 
Range on Protein: 1299-1605
Range on HMM: 3-265/392.0
PISVLDLPKHIAilKADNNSQFTQEYESIEPGQTFTADSSQMECNKGKNRYPNIHAYDHSRVRLSYINGIEGSDYINANFCDGYRKERAYIATQGPMQHT
|| | ..|  .   |   .. |..|.  .   . .   ..| | |. |||| ||  || .||.|  |. |  |||.|| . ...  |.||||.|||   .
pipvaqfpafve..knrhsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaas

AADFWRMVWEQRTFTIVMLTREEERGrvkcdqywptdgtdvyegievslvdwvelanytistlqickeGASQPREVKHFQFTGWPDHGVPAHPTPFLAFL
  ||||||..... ||.|.|. .|                                               . | |  |.|| |||..|| | . .| |.
lddfwrmvfqenvttiamvtklkegd..........................................kgddartvaqfhftewPdkdvpkhtssllkfi

RRVKFYNPPDAGPIVVHCSAGVGRTGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAVSCGNTEVHARNLLHHIKKLTEL
. ||      . |...||||||||||  | |||.. . ..   ||..  || .| .| |||||.||| | . |.|| .   || .    .  |...|   
kevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlsts

GKGEVTG
. |.|. 
sdGdvrs
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1315-1590 1.1e-58 193.4 In-house 6-280 (283) alignment 
Range on Protein: 1315-1590
Range on HMM: 6-280/283.0
DNNSQFTQEYESIEPGQtFTADSSQMECNKGKNRYPNIHAYDHSRVRLSYINGiegsDYINANFCD---GYRKERAYIATQGPMQHTAADFWRMVWEQRT
.||  | . .. .   .   || .  . || |||. .| ..|  ||.|   .     ||||| |      |.... ||..|.|...|  |||.||.... 
nnnklfrevlkrlsvpd.ldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdeki

FTIVMLTREEERGRVKCDQYWPTDGTDVYEGIEVSLVDWVELANYTISTLQICKEGASQP-REVKHFQFTGWPDHGVPAHPTPFLAFLRRVKFYNPPDAG
 .|||||.  |  |.|| |||| .|.  |    |.| . .    ..|  | . ......    . |.|. .| . |  |    .. | . .   .    |
taivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkg

PIVVHCSAGVGRTGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAVSCGNTEVHARNLLH
|||||||.|.|||. || . . .. .. |  ||..  |...| ||  .|||..|| . |...||   ||.|.. | .|  
PivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdlqs
subfamily_PTPN3_pd Subfamily PTPN3 1622-1862 1.6e-58 192.8 In-house 32-271 (280) alignment 
Range on Protein: 1622-1862
Range on HMM: 32-271/280.0
KYGAATLAINRPKNRLANILPYETTRVHISpvrGVEGsDYINASFID----GYRQRGLFIATQGPLQDTVDDFWRMLMEQNSNIIVMLTQLHEGEWEKCY
.  || .. | .|||  .||||..|||...     |  |||||....    .  .   .|||||||..|. |||.|. ||.|..|||||.| |    ||.
aisaarkpenlsknryrdilpydatrvklk...eset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkCh

KYWPTD-RSARHQYYIVDPIAEHEYPQFVIRDFKVKDARSDTVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRAYeqQEEEGPITVHCSDGVGRTGVF
.|||.   . ..  . |    |.|  ..|.|.. .||....  |.| |. .| ||. |||.. . ..... .|...   . .| |. |||| |.|||||.
qyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr..sgkeePvvvhCsaGigrtGvl

TALFIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTA
 .| . |  . ..  |   . |. .| || ..||...|| |  .. 
illetalalieaaepvypldivrtmrdqramlvqtasqykfvCeai
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1620-1866 9.6e-58 190.3 In-house 9-264 (270) alignment 
Range on Protein: 1620-1866
Range on HMM: 9-264/270.0
KHKYGAATLAINRPKNRLANILPYETTRVHISPVRGVEGSDYINASFIDGYRQ-RGLFIATQGPLQDTVDDFWRMLMEQNSNIIVMLTQLHEGEWEKCYK
...    . | ..  || |.|||  .||| .....  . . |||| .. |. . .  .||..|||. |. .||||..|.... |||.|.|.|   .|| .
tsesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCer

YWPTDRSA--RHQYYIVDPI--AEHEYPQFVIRDFKVKdaRSDTVRNIKQFHFLGWPETGVPKSGE------GIIDLIGQVQRAYEQQEEEGPITVHCSD
|||...    . ..  .  .  .|.    ....  ...  .. . |..  |..  ||. |||.. .       .. .. .|.|  .......|. ||||.
YWpaepkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsa

GVGRTGVFTALFIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYL
||||||.. || |... . ... ||. . .. || .|.|.||  ||| | ||. .|| 
GvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveya
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1604-1869 1.1e-57 190.0 In-house 15-296 (301) alignment 
Range on Protein: 1604-1869
Range on HMM: 15-296/301.0
TGLEEEFKVVDPSQAKKHKYGAAtlAINRPKNRLANILPYETTRVHISPVRG--VEGSDYINASFIDGYRQRGLFIATQGPLQDTVDDFWRMLMEQNSNI
...||..| ..  . |. . |      |.. ||  || .|.  |. ..| .   .   .|||||.||||...  |||.|||.. |. ||||.....    
nkfeeqykelkegedksctvgls..eenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvs

IVMLTQLHEGEWEKCYKYWPTDRSARHQYYIV--DPIAEHEYPQFVIRDFKVK--DAR------------SD-TVRNIKQFHFLGWPETGVPKSGEGIID
|||.|.|.||  .||..|||. .  ..... .    . |. ||.||||...||  |.             || . ... |..   ||. || .    .. 
ivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLq

LIGQVQRAyEQQEEEGPITVHCSDGVGRTGVFTALFIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYLGSF
 | .|  . .|. . ||. |||||.|.|.||. .. | ||  ..|||||.|| .| .| ..| .|.  ||| . |.   .||   
viddvihr.qqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqln
0051429 (Phosphotyrosine protein) phosphatases II 1368-1596 1e-56 187.8 In-house 1-244 (272) alignment 
Range on Protein: 1368-1596
Range on HMM: 1-244/272.0
IEGSDYINANFCDGYRK---ERAYIATQGPMQHTAADFWRMvWEQRTFTIVMLTREEERGRVKCDQYWP------------TDGTDVYEGIEVSLVDWVE
.. |.||||.. .|| .   ........||...|||||||. .|..  |||.|..||||||.|||.|||            .. |  |  . | |. .. 
lplsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

LANYTISTLQICKE-GASQPREVKHFQFTGWPDHGVPAHPtpFLAFLRRVKFynppdAGPIVVHCSAGVGRTGCFIVIDSMLERLRHEETVD--------
| .|.. .|.. .. .|...||| |...|.||||||| ..  .|..|. .        ||..||||||..|||...... .|... .|  ||        
lldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly

IYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAvSCGNTEVHARNLLHHIKKLT
... |  || || ..|||.|||.| ..|.||.  .. ..|.|. ||.... . 
leeaveelraqrpgavqteeqylflyeallel.lrsllsvraeyllaaldaid
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1612-1865 2.2e-56 185.8 In-house 19-276 (287) alignment 
Range on Protein: 1612-1865
Range on HMM: 19-276/287.0
VVDPSQAKKHKYGAATLAINRPKNRLANILPYETTRVHISpVRGVEGSDYINASFIDGYRQRGLFIATQGPLQDTVDDFWRMLMEQNSNIIVMLTQLHEG
. . |..    . ||.   .  ||| |..||.. ||| .|   |  ||||||| .. .|..   |||.|||.  || ||||...|..|  ....|.  | 
lkedsesstatfkaaeelaavkknryadvlPiddtrvlls.aegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtrevee

EWEKCYKYWPTDRSAR-H-QYYIVDPIAEHEYPQFVIRDFKVKDARSDTVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRAYEQ---QEEEGPITVHC
   |||||||  .       | .|    .   |.. .| ... |. .   | .||...| ||. ... .  |.| .. .|..  |     .| ||. ||.
arlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhd

SDGVGRTGVFTALFIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEY
. |.||.|.. |......|. . | ||  ..|  || .| |.||.  |. . |..   |
dvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvty
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1308-1582 1.9e-54 179.4 In-house 8-299 (301) alignment 
Range on Protein: 1308-1582
Range on HMM: 8-299/301.0
HIAILKADNnsqFTQEYESIEPGQTFTADSSQMECNKGKNRYPNIHAYDHSRVRLSYING--IEGSDYINANFCDGYRKERAYIATQGPMQHTAADFWRM
| |. ....   | ..|.... |.  ... .  | ||  ||. ||  ||. |. |.  .   .   .||||.. |||......||.||||..| .||||.
hvaakhsnk...feeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrl

VWEQRTFTIVMLTREEERGRVKCDQYWPTDGTDVYE--GIEVSLVDWVELANYTISTLQICKEGAS---------------QPREVKHFQFTGWPDHGVP
.|.... .|||.| ..|. . || ||||.  .. .|   ..| ||.   . ...|  |..  . .|               ....|  .| | ||..|| 
iwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvv

AHP-TPFLAFLRRVKFYNPPDAGPIVVHCSAGVGRTGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAVSCGNTE
  | |   .    ..  . .. ||.|||||..|.|.| .. ..  ||  . |  ||... .  .| ..  .|.| |||.. .|.| . ... .|.
reprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnsty
subfamily_PTPN14_pd Subfamily PTPN14 1609-1866 5.2e-54 178.3 In-house 28-296 (300) alignment 
Range on Protein: 1609-1866
Range on HMM: 28-296/300.0
EFKVVDPSQAkKHKYGAATLAINRPKNRLANILPYETTRVHISPVRGVeGSDYINASFIDGY--RQRGLFIATQGPLQDTVDDFWRMLMEQNSNIIVMLT
|.  . . .. . .. .|.|  | .|||  ..|||| .||..|| .    ..||||| |      ..  .|..||||. || |||.|. ||. ..|||||
eyeripkkre.dallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlt

QLHEGEWEKCYKYWPTDRS----ARHQYYIVDPIAEHEYPQFVIRDFKVKDARSDTVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRAYEQ-------
. .|.  ||..||.| . |    .... . |     .. .... . .|.|   |   |..  . .  ||. |||.  .| .. . .||   ..       
eeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseves

QEEEGPITVHCSDGVGRTGVFTALFIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYL
.|.. |. ||||.|||||||     .... .  . ..|. .... ||.||  .||.  || | ||. ..||
keskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1330-1573 6e-54 177.8 In-house 25-274 (287) alignment 
Range on Protein: 1330-1573
Range on HMM: 25-274/287.0
GQTFTADSSQMECNKGKNRYPNIHAYDHSRVRLSYiNGIEGSDYINANFCDGYRKERAYIATQGPMQHTAADFWRMVWEQRTFTIVMLTREEERGRVKCD
. |.|  ...   .  |||| ..  .|..|| ||  .|  ||||||||.  .|... |.||.|||.  |  ||||.|.|.|. .....||| | .| || 
sstatfkaaeelaavkknryadvlPiddtrvllsa.egelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcy

QYWPTDGTDVY-EGIEVSLVDWVEL-ANYTISTLQICKEGASQPREVKHFQFTGWPDHGVPAHPTPFLAFLRRVKF-----YNPPDAGPIVVHCSAGVGR
.|||     .   |  | |.|   .  .|.. .|.. .  . . | || ...  |||....     .. |   ||       .  ..||.|||...|.||
kywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGr

TGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAIL
.| .. .  ...||     ||.   |  || .|. .||.  |. .. .|. 
sGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1626-1865 7.9e-54 177.4 In-house 28-265 (283) alignment 
Range on Protein: 1626-1865
Range on HMM: 28-265/283.0
ATLAINRPKNRLANILPYETTRVHISPVRGvegsDYINASFID---GYRQRGLFIATQGPLQDTVDDFWRMLMEQNSNIIVMLTQLHEGEWEKCYKYWPT
|.   |..|||  .|.|..  ||.. .       |||||.||     |.|   .|..|.||..|| |||.|. ...   |||||.| |.. .|| .||| 
asadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPk

DRSARHQYYIVDPIAEHEYPQFVIRDFKVKDA---RSDTVrnIKQFHFLGWPETGvpksGEGIIDLIGQVQ--RAYEQQEEEGPITVHCSDGVGRTGVFT
. |  .  . |    |     |.|. . ..     .|  .  .  . . .| | |     . ||. . ..   ..  .....||| |||| |.|||.|| 
rGsedyGeftvtlrkettsnsfiikelllrvnssakstll..lahyqvidWleyg....eqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfi

ALFIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEY
|.   .. ...| |||.|..|| .| ||. .||...|| . .. .|| 
aasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleq
0041856 (Phosphotyrosine protein) phosphatases II 1343-1582 9.9e-54 177.0 In-house 1-177 (182) alignment 
Range on Protein: 1343-1582
Range on HMM: 1-177/182.0
NKGKNRYPNIHAYDHSRvrlsyingieGSDYINANFCDGYRKERAYIATQGPMQHTAADFWRMVWEQRTFTIVMLTreeergrvkCDQYWPTDGtdvyeg
|. ||||..|  |||||          ..||||||. .|... . .||||||...| |||.||..|..  |||.||         ...|||..       
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell......

ievslvdwvelanytistlqickegasqPREVKHFQFTGWPDHGVPAhPTPFLAFLRRVKFynppDAGPIVVHCSAGVGRTGCFIVIDSMLERlrheeTV
                            .|.. ......|||||||  .  .|.|...|.     . ||..|||||||||||...... |...      |
............................erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gv

DIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAVSCGNTE
...  |  .| .|. ||.| .||.| ..|.|| . ...|.
sleeavklvrsrRpgmvitpnqyfflqlallellllkktr
subfamily_PTPN1_pd Subfamily PTPN1 1617-1864 1e-52 173.7 In-house 18-269 (290) alignment 
Range on Protein: 1617-1864
Range on HMM: 18-269/290.0
QAKKHKYGAATLAINRPKNRLANILPYETTRVHISPVRGvegsDYINASFIDGYRQRGLFIATQGPLQDTVDDFWRMLMEQNSNIIVMLTQLHEGEWEKC
.|....  .| |  ||..||  .. ||. .|...         ||||||...  . .  .| ||||| .||| ||.|. ||.|  .||| .. | |  ||
easdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikc

YKYWPTDRS-----ARHQYYIVDPIAEHEYPQFVIRDFKVKDARSDTVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRAYEQQEEEGPITVHCSDGVG
..|||.. .       .  . |. |.|... ....| ..... ...  |.| .||.. ||. |||.|    .... .|...   ... ||  .||| |.|
aqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiG

RTGVFTALFIVLERMRSEG---VVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALE
|.| |. .  .| ..  ..    ||. ...  || .|  ..| ..|  | | . ||
rsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
0051429 (Phosphotyrosine protein) phosphatases II 1657-1868 4.4e-52 172.7 In-house 2-227 (272) alignment 
Range on Protein: 1657-1868
Range on HMM: 2-227/272.0
EGSDYINASFIDGYRQ---RGLFIATQGPLQDTVDDFWRMlMEQNSNIIVMLTQLHEGEWEKCYKYWP------------TDRSARHQYYIVDPIAEHEY
. |.||||....|| .   .|......|||. |..||||.  |.. . ||.|....| ...||..|||            .. . .. .. |  . |. .
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

PQFVIRDFKVKDA-RSDTVRNIKQFHFLGWPETGVPKSGegIIDLIGQVQRayeqqeeEGPITVHCSDGVGRTGVFTALFIVLERMRSEGVVD-------
. ...| . ..     ...| . ..|...||  |||..   ...|. ....       .||. |||| |..|||.. ||...|...  | .||       
ldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnl

-LFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYLGS
 |...|. || |||..||..|||||.|. .||.| |
yleeaveelraqrpgavqteeqylflyeallellrs
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1621-1866 1.4e-50 166.8 In-house 35-236 (392) alignment 
Range on Protein: 1621-1866
Range on HMM: 35-236/392.0
HKYGAATLAINRPKNRLANILPYETTRVHISPVRGVEGSDYINASFIDGYRQRGLFIATQGPLQDTVDDFWRMLMEQNSNIIVMLTQLHEGEwekcykyw
..  .|   || .|||  |||||...||..  .  .  |||.|||.|... .   .||.|||   ..||||||....|   |.|.|.|.||.        
ypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd........

ptdrsarhqyyivdpiaeheypqfvirdfkvkdaRSDTVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRAYEQQEEegPITVHCSDGVGRTGVFTALF
                                  . | .| . ||||  ||. .|||    .. .| .|.  . |     |. .||| |||||||  .. 
..................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqyth..pliihcsagvgrtgvvisid

IVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYL
 |. . .   .||.|. |  .| .|| |||..||| | | . || |
svvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledl
0036282 (Phosphotyrosine protein) phosphatases II 1370-1567 2.1e-50 166.1 In-house 1-161 (174) alignment 
Range on Protein: 1370-1567
Range on HMM: 1-161/174.0
GSDYINANFCDGYRKERAYIATQGPMQhtaadFWRMVWEQRTFTIVMLTREEERGRVKCDQYWPTdgtdvyegievslvdwvelanytistlqickEGAS
|||||||...|...  . .||.|||..     ||.|..|..  |.|||..|.|.|..|| .|||.                                  .
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lred

QPREVKHFQFTGWPDHGVPAHPTpFLAFLRRVKFYNPP-DAGPIVVHCSAGVGRTGCFIVIDSMLERLRhEETVDIYGHVTVLRTQRNYMVQTQEQYIF
  |.. ......|||||||  .. .| |...|. .    . ||..|||||||||||...... || .|. | .||.. .|  ||.|| .||||..||.|
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf
subfamily_ptpA1_pd Subfamily ptpA1 1301-1538 4.7e-50 165.5 In-house 9-258 (418) alignment 
Range on Protein: 1301-1538
Range on HMM: 9-258/418.0
SVLDLPKHIAILKAdNNSQFTQEYESIEPGQTFTADSsqmECNKGKNRYPNIHAYDHSRVRLSYINGIEGSDYINANFCDGYRkERAYIATQGPMQHTAA
|. .| .||  ..   . .|    ||. | .|   |    . |  |||| ||   .|.||.|  |.  |||||||||. ||    . .|.||||.  | |
siynlknhikcihk.ikeefrlleesvgpsetsegdk...khntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntia

DFWRMVWEQRTFTIVMLTREEERGRVKCDQYWPT-----------DGTDVYEGIEVSLVDWVELANYTISTLQICKEGASQPREVKHFQFTGWPDHGVPA
||||||||.|   ||||.|| |  |.|||.|||            .| .|.    | ||. ..  .  | | .|      . |.. ..|. ||||| .| 
dfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipd

HPTPFLAFLRRVKFY-----NPPD-AGPIVVHCSAGVGRTGCFIVIDSMLERLRH
|  ||  .|. .           |   ||.||||||||||| |     |...| |
htqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkldh
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1631-1864 9.2e-50 164.1 In-house 3-237 (237) alignment 
Range on Protein: 1631-1864
Range on HMM: 3-237/237.0
NRPKNRLANILPYETTRVHISPVRGveGSDYINASFIDGYRQR-GLFIATQGPLQDTVDDFWRMLMEQNSNIIVMLTQLHEGEWEKCYKYWP-TDRSARH
|. ||| .||  |. .|| .    .  |||||||....|.      .||.||||. . ||||.|. ...  .||||| | ||. .||.|||| ||. | .
nkiknrygnivaydhsrvvlkgags..gsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

QYYIVDPIAEHEYPQFVIRDFKVK-DARSDTVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRAYEQQEEEGPITVHCSDGVGRTGVFTALFIVLERMR
  . |    . |. .. .| . .    .   || |.|..|  ||. |||.    .. .  ..    .   | ||  .||| ||||||.|  .  .| . .
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

SEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALE
 . |||... |. .  .|| ..|...||.| ..| ||
ekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
0041856 (Phosphotyrosine protein) phosphatases II 1631-1866 3.2e-49 162.3 In-house 1-171 (182) alignment 
Range on Protein: 1631-1866
Range on HMM: 1-171/182.0
NRPKNRLANILPYETTRvhispvrgveGSDYINASFIDGYRQRGLFIATQGPLQDTVDDFWRMLMEQNSNIIVMLTqlhegewekCYKYWPtdrsarhqy
|..|||  .||||. .|          ..|||||....|..    ||||||||..|| ||.||| |.. ..||.||         .. |||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

yivdpiaeheypqfvirdfkvkdarSDTVRNIKQFHFLGWPETGVPKsGEGIIDLIGQVQRayeqqeEEGPITVHCSDGVGRTGVFTALFIVLERmrseG
                         ..  |.. |...|.||  |||   . ..|.| .|..      |.||. |||| ||||||.. |.......    |
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgtlvaaylmkkl....g

vVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYL
 |.|...|||.| .|| ||.. .|| |..  .||.|
.vsleeavklvrsrRpgmvitpnqyfflqlallell
0036282 (Phosphotyrosine protein) phosphatases II 1658-1860 6.4e-49 161.3 In-house 1-164 (174) alignment 
Range on Protein: 1658-1860
Range on HMM: 1-164/174.0
GSDYINASFIDGYRQRGLFIATQGPLQdtvddFWRMLMEQNSNIIVMLTQLHEGEWEKCYKYWPTdrsarhqyyivdpiaeheypqfvirdfkvkdARSD
||||||||..|...  . .||.||||.     ||.|| |......|||....| . .||. |||.                                |.|
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lred

TVRNIKQFHFLGWPETGVPKSGEgIIDLIGQVQRAYEQqEEEGPITVHCSDGVGRTGVFTALFIVLERMRsEGVVDLFQTVKLLRTQRPAMVQSQEQYLF
 .|.. |...|.||  ||| . . ..... .|..|...  ..||. |||| ||||||.. |....| ... |..|| ...|. ||.||| |||...|| |
lerlgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf

CYK
.|.
lyy
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1626-1864 7.5e-47 154.5 In-house 2-238 (239) alignment 
Range on Protein: 1626-1864
Range on HMM: 2-238/239.0
ATLAINRPKNRLANILPYETTRVHISPVRGVEGSDYINASFIDGYRQ-RGLFIATQGPLQDTVDDFWRMLMEQNSNIIVMLTQLHEGEWEKCYKYWPTDR
|   .|. ||| |||. |. .|| .  .     |||||||..  |      .||||| .. .  |||||. ..   .||||| | ||  .||..|||   
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

SARHQYyIVDPIAEHEYPQFVIRDFKVKDARSDTVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRayEQQEEEGPITVHCSDGVGRTGVFTALFIVLE
|   .   |       . ...|| | . .      | . |.||  ||. |||.    .. |  .. .  .      |  .||| |||||| |  .  .| 
skycnl.rvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitk..dslpgarpwvihcsagvgrtgaflvidamlr

RMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALE
. . .  ||.|. || .| .|| |||. |||.| . . ||
qakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1625-1864 7.6e-47 154.5 In-house 2-239 (239) alignment 
Range on Protein: 1625-1864
Range on HMM: 2-239/239.0
AATLAINRPKNRLANILPYETTRVHISPVRGVEGSDYINASFIDGYRQ-RGLFIATQGPLQDTVDDFWRMLMEQNSNIIVMLTQLHEGEWEKCYKYWPTD
||   .|. ||| |||. |. .|| .  .     |||||||..  |      .||||| .. .  |||||. ..   .||||| | ||  .||..|||  
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

RSARHQYyIVDPIAEHEYPQFVIRDFKVKDARSDTVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRayEQQEEEGPITVHCSDGVGRTGVFTALFIVL
 |   .   |       . ...|| | . .      | . |.||  ||. |||.    .. |  .. .  .      |  .||| |||||| |  .  .|
tskycnl.rvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitk..dslpgarpwvihcsagvgrtgaflvidaml

ERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALE
 . . .  ||.|. || .| .|| |||. |||.| . . ||
rqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
0049772 (Phosphotyrosine protein) phosphatases II 1336-1579 2.5e-46 154.2 In-house 39-283 (314) alignment 
Range on Protein: 1336-1579
Range on HMM: 39-283/314.0
DSSQMECNKGKNRYPNIHAYDhSRVRLSYINgIEGSDYINANFCDGYrkeRAYIATQGPMQHTAADF----------WRMV--WEQRTFTIVM-------
  .. ..|. ||||..|  .| .||.|.. . ..|||||||.. ||.   ...||||||...|  ||          ||||  ..... .|||       
lvadlflnrdknryldilpad.nrvilpglp.vsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevla

--------------LTREEERGrvkcDQYWPTDGTDVYegievslvdwvelanytistlQICKEGASQPREVKHFQFTGWPDHGVPaHPTPFLAFLRRVK
              |..  ..|    ..... |  .                       ... ..   .|.. ..  . .||...|  .  |..||. ..
delsrLdaAlgKtpllildgng....neptaadlellk.....................eelydpelferlgikylripvpDgsap.lledfdeflefie

FYnpPDAGPIVVHCSAGVGRTGCFIVIDSMLERLRHeETVDIYGHVTVLRTqRN---YMVQTQEQYIFSHDAILEAVSCG
 .  .. ||..|||.||.||||.|.|.. .. .|.     ... .|   |.  |    .....|||.| ..|.||...  
ea..dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRp.inpnpgfieqleqyefilealleylkfl
0043147 (Phosphotyrosine protein) phosphatases II 1369-1569 5.2e-46 151.8 In-house 3-154 (172) alignment 
Range on Protein: 1369-1569
Range on HMM: 3-154/172.0
EGSDYINANFCDGYRKERAYIATQGPMQHTAADFWRMVWEQRTFTIVMLTREeergrvkcdqywptdgtdvyegievslvdwvelanytistlqiCKEGA
||||||||.. |.|.. . .||||||...| ||||||..|.   .||.||..                                           .. . 
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

SQPREVKHFQFTGWPDHGVPaHPTPFLAFLRRVKF-YNPPDAGPIVVHCSAGVGRTGCFIVIDSMLerlrheETVDIYGHVTVLRTQRNYMVQTQEQYIF
   |.. ......||||||| ..  .| ||. ..  ..  . ||..|||||||||||...... ||      . ....  |  .|..|...||...||.|
llerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrf

SH
 .
ly
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1315-1575 5.9e-45 148.4 In-house 3-258 (267) alignment 
Range on Protein: 1315-1575
Range on HMM: 3-258/267.0
DNNSQFTQEYESIEPGQTFTAD--SSQMECNKGKNRYPNIHAYDHSRVRLSYINgiegSDYINANFCDGYRKERAYIATQGPMQHTAADFWRMVWEQRTF
|.. .. .|.| |.   . ..    |  | |. .||. .   ||..|| |.  .     .|||| . .||....|.|.||.|.. | .||. .. .|.  
deeceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtke....eeyinasyvegyktknafivtqdplkntitdfltvihdqkvp

TIVMLTREeerGRVKCDQYWPTD--GTDVYEGIEVSLVDWVELANYTISTLQICKEGASqPREVKHFQFTGWPdhgVPAHPTPF----LAFLRRVKFYNp
.||.||.    .  .  ..||     .  |. . |      |  .| | ||..  .  |  ..|  . .  |    . .   |.    .. | . .. | 
vivlltkv...ftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknes.ahnvtlyyykkwn...intnnkpylkplfgilaknqlen.

pDAGPIVVHCSAGVGRTGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEA
    |.||.||.||||.| |.||||.|||...|...||.  .  .| ||  .|.|.|.||. |. . | 
.gnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
0049772 (Phosphotyrosine protein) phosphatases II 1601-1866 1.1e-44 148.8 In-house 16-280 (314) alignment 
Range on Protein: 1601-1866
Range on HMM: 16-280/314.0
GEVTGLEEEFKVVDPSQAKKHKYGAATLAINRPKNRLANILPYEtTRVHIsPVRGVEGSDYINASFIDGYRQrglFIATQGPLQDTVDDF----------
.....|. .......|.  .. . .| |  || |||  .|||.. .||.. |  .|.||||||||..||...   ||||||||. ||.||          
ddllklllvlnrrslsvlpeltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgflk...fIatqgpleitvvdfreepvlyyng

WRML--MEQNSNIIVM---------------------LTQLHEGEwekcykywptdrsarH----------QyyivdpiaeheypqfvirdfKVKDARSD
|||    ..|. .|||                     |..| ..                           .                    .. . ...
wrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng...............neptaadlellk....................eelydpel

TVRNIKQFHFLGWPETGVPkSGEGIIDLIGQVQRAyeqqEEEGPITVHCSDGVGRTGVFTALFIVLERMrseGVvDLFQTVKLLRTQRP-----AMVQSQ
  |.. ... . .|  ..| . | . ...  ...|    ...||. |||..|.||||.| .. ... ..   || .| .... .| .||      .....
ferlgikylripvpDgsap.lledfdeflefieea....dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieql

EQYLFCYKTALEYL
|||.|...  ||||
eqyefilealleyl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1606-1865 4.7e-44 145.4 In-house 8-258 (267) alignment 
Range on Protein: 1606-1865
Range on HMM: 8-258/267.0
LEEEFKVVDPSQAKKHKYGAATLAINRPKNRLANILPYETTRVHISPvrgvEGSDYINASFIDGYRQRGLFIATQGPLQDTVDDFWRMLMEQNSNIIVML
.|.||. ..    .. .        |. .||| . |||. ||| ..     .  .|||||...||...  ||.||.||. |. ||. ....|.  .||.|
iekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrt....keeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivll

TQLHEGEWEKcykYWPTD--RSARHQYYIVDPIAEHEYPQFVIRDFKVKdARSDTVRNIKQFHFLGWPETGVPKSgeGIIDLIGQVQRAyEQQEEEGPIT
|.  ...  .   .||    .. ..|   |.   |.|  .. |  ...|  . .. .|.  ...  |      |    .  |.| . .  . .. . |. 
tkvftdnirl...fwPPkmgqakkyqdltvehslekeendyqiitlelk.fknesahnvtlyyykkwnintnnkp..ylkplfgilakn.qlengnrPlv

VHCSDGVGRTGVFTALFIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEY
|.|||||||.| |  .   |||.. |||.|.|. .. .| ||...|...|.|......  ||
vacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
0049260 (Phosphotyrosine protein) phosphatases II 1378-1569 7.1e-44 144.5 In-house 1-143 (152) alignment 
Range on Protein: 1378-1569
Range on HMM: 1-143/152.0
FCDGYRKERAYIATQGPMQHTAADFWRMVWEQRTFTIVMLTREEERGRVKCDQYWptdgtdvyegievslvdwvelanytistlqickegasqprevkHF
| |||.. ...||||||. .|.||||||..|.   ||||||...|.|..||.||.                                           ..
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qy

QFTGWPDHGVPAHPTPFLAFLRRVKFYNPPDAGPIVVHCSAGVGRTGCFIVIDSMLerlrheETVDIYGHVTVLRTQRNYMVQTQEQYIFSH
... ||||||| ..  .| .|. .....  . ||..|||||||||||...... ||        |...  |  .|..|...|....|..| .
lhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
0046846 (Phosphotyrosine protein) phosphatases II 1367-1574 1.7e-43 143.7 In-house 8-171 (176) alignment 
Range on Protein: 1367-1574
Range on HMM: 8-171/176.0
GIEGSDYINANFCDGYRkeraYIATQGPMQHTAADFWRMVWEQRTFTIVMLTREEERGRVKCDQYWPTdgtDVYEGIevslvdwvelanytistlqicke
  ...||||||. .|.|    .||||||. .| |||..|..|..  ..|.|| | | ||.||..|||       .||                       
ldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe...leklgi.......................

gasqprevkHFQFTGWPDHGVPAHpTPFLAFLRRVKFYNPPDaGPIVVHCSAGVGRTGCFIVIDsmleRLRHEETVDIYGHVTVLRTQRN-YMVQTQEQY
         ......||||||| . . .| .|. .. .   . ||..||||||.||||......     |..|  ....  .  .| ||  ..|||.|||
.........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQy

IFSHDAILE
 | ....|.
rflyefell
0046846 (Phosphotyrosine protein) phosphatases II 1656-1867 5.3e-43 142.1 In-house 9-174 (176) alignment 
Range on Protein: 1656-1867
Range on HMM: 9-174/176.0
VEGSDYINASFIDGYRqrglFIATQGPLQDTVDDFWRMLMEQNSNIIVMLTQLHEGEWEKCYKYWPTDRSARHqyyivdpiaeheypqfvirdfkvkdar
 ...|||||..|.|.|    .||||||| .|. ||..|| |.. ...|.||...| .. ||. |||  ... .                           
dldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...........................

sdtvrnikQFHFLGWPETGVPKSgEGIIDLIGQVQRAYEQQeeeGPITVHCSDGVGRTGVFTALFivleRMRSEGVVDLFQTVKLLRTQRP-AMVQSQEQ
        |...|.||. ||| . | ...|. ....|...    ||. |||| |.||||.. |..     ...|  ........|.| |||  .||..||
........qylhlpwpDhgvpdl.elllellefirealkeg...gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQ

YLFCYKTALEYLG
| |.|. .|..|.
yrflyefellllk
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1338-1576 6.7e-43 141.8 In-house 36-277 (307) alignment 
Range on Protein: 1338-1576
Range on HMM: 36-277/307.0
SQMECNKGKNRYPNIHAYDHSRVRLSyINGIeGSDYINANFCDGYRKERAYIATQGPMQHTAADFWRMVWEQRTFTIVMLTREEERGRVKCDQYWPTDG-
  ...|  |||| .... |..|. .  ..|.  |||| ||.     | . .|..|||.. |  .|| |. ...  ...|| .  | ...||.|||| .  
eafsantdknryqdvkcqdkgrivvk.fdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleeg

-TDVY----EGIEVSLVDWVELA--NYTISTLQICKEGASQPREVKHFQFTGWPDHGVPAHPTPFLAFLRRVKFynppDAGPIVVHCSAGVGRTGCFIVI
 . |.    . | |. .   .||  .  |   ..  . |.. | ..|.|.. |||.|||      . .|  |..    |  |.||||||||||.|  . |
qklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry....dtnpvvvhcsaGvGrsGtivai

DSMLERL-RHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAV
  . ... . ..  |.   |  ||.||.| .||. ||.. |  .||  
slvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1323-1574 9.2e-43 140.9 In-house 36-281 (290) alignment 
Range on Protein: 1323-1574
Range on HMM: 36-281/290.0
EYESIEPGQTFTADSSQMECNKGKNRYPNIHAYDHSRVRLSyiNGIEGsDYINANFCDGYRkeRAYIATQGPMQHTAADFWRMVWEQRTFTIVMLTREEE
.     |.| .  .  . . .  |||| ..   | .|| |.  .| .| ||. ||. .| .    .| |||... |. |.|||| .... .||||    |
klkpylpvqylerkifdkntefkknrykdvvcndktrvilk..dGydG.dyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlcelie

RGRVKCDQYWPTDGTDVYEGIEVSL--VDW-VELANYTISTLQICKEGASQPREVKHFQFTGWPDHGVPAHPTPFLAFLRRVKfynpPDAGPIVVHCSAG
 |. ||.||.|    .|    |...       . ||    || . .  . .   .||..   |||. |.     .|  || ..      .||.|||||||
dGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilr....kasGpvvvhcsaG

VGRTGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILE
.|||| |. |.  |. | .   .|. . |  ||  |   || . ||.   ...|.
iGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld
0043147 (Phosphotyrosine protein) phosphatases II 1657-1860 2.6e-42 139.8 In-house 3-155 (172) alignment 
Range on Protein: 1657-1860
Range on HMM: 3-155/172.0
EGSDYINASFIDGYRQRGLFIATQGPLQDTVDDFWRMLMEQNSNIIVMLTQLhegewekcykywptdrsarhqyyivdpiaeheypqfvirdfkvKDARS
|||||||||..|.|.    ||||||||. |..|||||| |.. ..||.||.|                                              ..
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

DTVRNIKQFHFLGWPETGVPkSGEGIIDLIGQVQRAYeQQEEEGPITVHCSDGVGRTGVFTALFIVLERMrsegvvDLFQTVKLLRTQRPAMVQSQEQYL
. .|.. |...|.||  ||| . | ..... ...... .....||. |||| ||||||.. |....|...      .|...|.|.|..|| .||...|| 
llerlgiqylylpwpDhgvp.llellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylmllgl......sleeavalvrekRpgavqnpsqyr

FCYK
|.|.
flyy
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1631-1864 5.5e-42 138.6 In-house 33-293 (297) alignment 
Range on Protein: 1631-1864
Range on HMM: 33-293/297.0
NRPKNRLANILPYETTRVHIspVRGVEGSDYINASFIDGY--RQRGLFIATQGPLQDTVDDFWRMLMEQNSNIIVMLTQLHEGEWEKCYKYWPTDRSARH
   |||  .|| ...|||..   |.. ..||||| ..      .   .| .||||..||||||....||. ..|||...| |.  .||. |||     | 
slrknryrdilatddtrvkl..lrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerl

--QYYIVDPIAE--HEYPQFVIRDFKVKDArsDTVRNIKQFHFLGWPETGVPKSGE--------------------GIID-----LIGQVQRAYEQQEEE
    ..|. ...   |. . .. ....     .  | ..   ||.||. |||   |                    ....     .. |..    ..  .
kagdvvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraemprn

GPITVHCSDGVGRTGVFTALFIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALE
 .. |||| ||||.||     ..|...| . . |    .. || ||. .||. ||. ..|. .|.
ayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1343-1574 9.8e-42 137.7 In-house 48-285 (305) alignment 
Range on Protein: 1343-1574
Range on HMM: 48-285/305.0
NKGKNRYPNIHAYDHSRVRLsyiNGIEGSDYINANFCDGYRKERAYIATQGPMQHTAADFWRMVWEQRTFTIVMLTREEERGRVKCDQYWPTDGTDVYEG
..||||| ..   |. ||.|   .|    .|| ||.     . . .| || |...| |||| | ....  .| ||    |.|  || .|....  || | 
eagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlef

------IEVS-----LVDWVELANYTISTLQICKEGAS-QPREVKHFQFTGWPDHGVPAHPTPFLAFLRRVKfynpPDAGPIVVHCSAGVGRTGCFIVID
      | |       ..... |. ...  ..  ||.  . | |.|. .  ||| ||||  .  | .| . .    |  ||||||||||.||||  ....
eekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekar....pskgpivvhcsagigrtgsvvmle

SMLERLRHEETVDIYGHV-TVLRTQRNYMVQTQEQYIFSHDAILE
 .|..|   . ..   ..   .| |||  .||..||.| |. ||.
yildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1332-1574 2e-41 136.6 In-house 45-287 (305) alignment 
Range on Protein: 1332-1574
Range on HMM: 45-287/305.0
TFTADSSqMECNKGKNRYPNIHAYDHSRVRLSYINgieGSDYINANFCDG-YRKERAYIATQGPMQHTAADFWRMVWEQRTFTIVMLTREEERGRVKCDQ
.| |. |  . .. |||| .. . |.| |.|.  .    |||| ||.       |. .|..|||...|  .|| || ...   |||| .  | |..|| |
afnanqs.adiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaq

YWPTD---GTDVYEGIEVSLVDWVE----LANYTISTLQICKEGaSQPREVKHFQFTGWPDHGVPAHPTPFLAFLRRVKFynppDAGPIVVHCSAGVGRT
|||.      ..  || |  |         |.  |..|...  | .|   |.|.|.| ||| |||      | .|  ..        |||||||||.|||
ywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysg.dqkmsvrhlqwtewpdrgvppckltslellsairg....skvpivvhcsagigrt

GCFIVIDSMLERLRHEETV-DIYGHVTVLRTQRNYMVQTQEQYIFSHDAILE
|  . |. .||..  .  .  .   |  || || . .|.. ||.| |  .|.
gtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln
0049260 (Phosphotyrosine protein) phosphatases II 1666-1860 8.1e-40 131.3 In-house 1-144 (152) alignment 
Range on Protein: 1666-1860
Range on HMM: 1-144/152.0
FIDGYRQRGLFIATQGPLQDTVDDFWRMLMEQNSNIIVMLTQLHEGEWEKCYKYWptdrsarhqyyivdpiaeheypqfvirdfkvkdarsdtvrnikQF
|||||..   |||||||.  |..|||||| |.. ..|||||.|.|  ..||..|.                                           |.
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qy

HFLGWPETGVPKSGEGIIDLIGQVQRAyeQQEEEGPITVHCSDGVGRTGVFTALFIVLermrseGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYK
..| ||  |||.. . ...|.  ....  .....||. |||| ||||||.. |....|        |.|...|.|.|..|| .|....|. |.|.
lhlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1338-1573 4.3e-39 128.9 In-house 32-266 (281) alignment 
Range on Protein: 1338-1573
Range on HMM: 32-266/281.0
SQMECNKGKNRYPNIHAYDHSRVRLSY-INGIEGSDYINANFCDGYRKERAYIATQGPMQHTAADFWRMVWEQRTFTIVMLTREEERGRVKCDQYWPTDG
 .   |. |||| || . | |||.| . .   . .||| ||.      .| || |||| . | ||||||.|.. | .|||| .  |  | || .|.| . 
fnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprna

TDV--YEGIEVSLVDWVELANYTISTLQICKEGasQPREVKHFQFTGWPDHGVPAHPTPFLAFLRRVKFYnppdAGPIVVHCSAGVGRTGCFIVIDSMLE
  .  .. . ||  |         . |..  ||  . | . |. .  |||  ||     .|  ||...      . | |.||||||||.| .. ..  |.
hcclqfdklsvsyedstvnkslvttrlnlsyeg..etrlithwlwkewpdwqvpessevmlkilrkirar....stppvihcsagvgrsgtlmaveialq

RLRHEET-VDIYGHVTVLR-TQRNYMVQTQEQYIFSHDAIL
 ..   |  ||   |. || | |   ||| .||..    .|
sihshftlpdikqivshlrvtgraasvqtlqqymliwkvll
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1340-1588 1.9e-37 123.5 In-house 49-301 (310) alignment 
Range on Protein: 1340-1588
Range on HMM: 49-301/310.0
MECNKGKNRYPNIHAYDHSRVRLSyINGIEGSDYINANFCDGYRKERAYIATQGPMQHTAADFWRMVWEQRTFTIVMLTREEERGRVKCDQYWPTDG-TD
.. .  |||| ..   | |||.|  |.     ||| ||.        ..| .|||.|||  |||||....|. .|..| .  | || ||  |||. | |.
ykkymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvte

VYEGIEVSLV----DWVELANYTISTLQICKEGASQPREVKH-----FQFTGWPDHGVPAHPTPFL--AFLRRVKfynppdAGPIVVHCSAGVGRTGCFI
 |  | |. .    .  |. | ... .        || ..|.      ..  ||| |||      .   .| .|.       || |||||||..|... .
tygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvr......hgpcvvhcsagkdrlyvvv

VIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILeAVSCGNTEVHARNL
 ..  ...|.. . ||.   .| |. .|   .||. ||.. .   . . . |.|||  . |
alklkidkldrglkvdaeevktellksraiciqtelqyliidrvri.ifargetevaekil
0051082 (Phosphotyrosine protein) phosphatases II 1370-1573 3.1e-37 122.8 In-house 2-150 (151) alignment 
Range on Protein: 1370-1573
Range on HMM: 2-150/151.0
GSDYINANFCDGYrkeraYIATQGPMQhtaaDFWRMVWEQRTFTIVMLTREEERGrvKCDQYWPTDGtdvyegievslvdwvelanytistlqickegas
 |||||... .|.     .....||..    ||.....|.   |||.|. |||||  .| .|.|  |                                 
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

qpREVKHFQFTGWPDHGVPAHPTPFLAFLRRVKFynpPDAGPIVVHCSAGVGRTGCFIVIDSMLERlrheetVDIYGHVTVLRTQRNYMVQTQEQYIFSH
  .||.|.....|||.|.| ..  .|.||. .     .. ||..||||||.||||...... ||..      |...  .  .| .| ..||. .|..| .
..ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfql

DAIL
 |.|
fall
0044763 (Phosphotyrosine protein) phosphatases II 1642-1865 6e-37 122.3 In-house 1-170 (178) alignment 
Range on Protein: 1642-1865
Range on HMM: 1-170/178.0
PYETTRVHISPVRGVEGSDYINASFIDGYrqrgLFIATQGPlqdtvDDFWRMLMEQNSNIIVMLTQLHEGEWEKCYKYWPTDRSarhqyyivdpiaehey
|.. |||..|...|.|.|||||||.|...    |......|      |....| |.. . ||.||.  |.  .||..|||.. .                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

pqfvirdfkvkdarsdtvrniKQFHFLGWPETGVPKSGEGIIDLIGQVQRAYEqqEEEGPITVHCSDGVGRTGVFTALFIVLERmrseGVvDLFQTVKLL
                      |......|  ||| . | . ...  ...|..  |..||. |||| ||||.|.. |.......    |. .|.. ..|.
.....................iqylhipipDhgvpdllehflefvefieeald..ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielv

RTQRPaMVQSQEQYLFCYKTALEY
| .|| .|....|. ..|. .|..
rerRp.ivpnpgqlrqLyefelrl
0051082 (Phosphotyrosine protein) phosphatases II 1658-1861 8.7e-36 118.1 In-house 2-148 (151) alignment 
Range on Protein: 1658-1861
Range on HMM: 2-148/151.0
GSDYINASFIDGYrqrglFIATQGPLQdtvdDFWRMLMEQNSNIIVMLTQLHEGEweKCYKYWPTDRsarhqyyivdpiaeheypqfvirdfkvkdarsd
 |||||.|...|.     .....|||.    ||...| |.. . ||.|....| .  .|..|.|                                    
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

tvRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRayeqqEEEGPITVHCSDGVGRTGVFTALFIVLERmrsegvVDLFQTVKLLRTQRPAMVQSQEQYLF
  ........|.||..|.| | . ..... ....      ..||. |||| |.||||.. ||...|..      |.|..... .| .|| .||. .|.||
..ievlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflf

CYKT
... 
qlfa
0044763 (Phosphotyrosine protein) phosphatases II 1355-1567 1.6e-35 117.7 In-house 2-162 (178) alignment 
Range on Protein: 1355-1567
Range on HMM: 2-162/178.0
YDHSRVRLSYINGIEGSDYINANFCDGYrkerAYIATQGPmqhtaADFWRMVWEQRTFTIVMLTREEERGRVKCDQYWPTDGTdvyegievslvdwvela
.|..|| || . |.|.||||||.. ...     |.....|     ||......|.   .||.|| | |.|..|||.|||..                   
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

nytistlqickegasqprevKHFQFTGWPDHGVPAHPTPFLAFLRRVKFYNPPDAGPIVVHCSAGVGRTGCFIVIDSMLERlrheeTVDIYGHVTVLRTQ
                     .......||||||  .  ||.|.. .. . ... ||..|||||||||.|...... |...      ....  .  .| .
....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrer

RNyMVQTQEQYIF
|. .|....|. .
Rp.ivpnpgqlrq
PTPc_DSPc_SM00012 1473-1574 2.5e-35 116.2 In-house 1-105 (105) alignment 
Range on Protein: 1473-1574
Range on HMM: 1-105/105.0
EVKHFQFTGWPDHGVPAHPTPFLAFLRRVKFYNPPD--AGPIVVHCSAGVGRTGCFIVIDSMLERLRHE-ETVDIYGHVTVLRTQRNYMVQTQEQYIFSH
.|||...||||||||| .....| .|| ||  .     ..|.||||||||||||.|...| .|..|..| ..|||.  |  ||.||. ||||.|||.| .
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

DAILE
.|.||
ralle
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1603-1866 3.6e-35 116.4 In-house 15-277 (307) alignment 
Range on Protein: 1603-1866
Range on HMM: 15-277/307.0
VTGLEEEFKVVDPSQAKkhKYGAATLAINRPKNRLANILPYETTRVHISpVRGVeGSDYINASFIDGYRQRGLFIATQGPLQDTVDDFWRMLMEQNSNII
|. | .||.|.   . .     . ..  |  |||  ..   . .|. .  . |.  |||| | ..    .   ||..||||..|. .|| | .... . .
vqalvdefrvlakktpe..gvtveafsantdknryqdvkcqdkgrivvk.fdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesv

VMLTQLHEGEWEKCYKYWPTDRSARHQYYIV-------DPIAEHEYP-QFVIRDFKVKDARSDTVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQraYe
.|| .. |    || .||| ..  .  .          .  |..  | . .|   ..|   ..  | |... .  ||. |||.   . |.|.  |.  | 
imlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavr..y.

qqeEEGPITVHCSDGVGRTGVFTALFIVLERM-RSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYL
   .. |. |||| ||||.|   |. .| ..| . .   |. . |. ||.||.  .|.. |||. ..  |||.
...dtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1317-1578 4.1e-35 116.0 In-house 18-278 (312) alignment 
Range on Protein: 1317-1578
Range on HMM: 18-278/312.0
NSQFTQEYESIepGQTFT-ADSSQMECNKGKNRYPNIHAYDHSRVRLSyinGIEgSDYINANFCDGYRKERAYIATQGPMQHTAADFWRMVWEQRTFTIV
  |.|.|| ..  |. .. .. . .   |  ||||||  .|  |  |.   | |   || |||     |   ...||||.. |.. ||...    . .|.
pqqltkeykav..gnivsdsectaflkfkdlnrypniqcwdrgrftla...gde.nfyihanfvkictkperfvctqgplentcthfwqlalslgstsii

MLTREEERGRVKCDQYWPTD-------GTDVYEG--IEVSLvDWVELANYTISTLQICKEGASQPREVKHFQFTGWPDHGVPAHPTPFLAFLRRVKfynp
.|.   | |  || .|              ||     |. .       . |   |..    . |   ..|.|.. |||||.|      | .|  ||    
llcgfvedgsekcakyisdivgfvdledhrvyteycteiei.ggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavk....

PDAGPIVVHCSAGVGRTGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAVSC
 |  |.. |||||||||| ...|.||.  |||    ..     .|| .|   |..  ||...  ..|| . .
kdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflys
PTPc_DSPc_SM00012 1762-1863 5.6e-35 115.1 In-house 2-104 (105) alignment 
Range on Protein: 1762-1863
Range on HMM: 2-104/105.0
IKQFHFLGWPETGVPKSGEGIIDLIGQVQRAYEQQEEEGPITVHCSDGVGRTGVFTALFIVLERMRSE-GVVDLFQTVKLLRTQRPAMVQSQEQYLFCYK
.|..|..|||..|||.... |..|. .|.. ....|...|. ||||.||||||.|.|| |.|.....| . ||.||.|| ||.||| |||..|||||.|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

TAL
  |
all
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1633-1867 7.1e-35 115.0 In-house 58-284 (290) alignment 
Range on Protein: 1633-1867
Range on HMM: 58-284/290.0
PKNRLANILPYETTRVHISpvRGVEGsDYINASFIDGYRqrGLFIATQGPLQDTVDDFWRMLMEQNSNIIVMLTQLHEGEWEKCYKYWPTDRSARH---Q
 |||  ..   . ||| ..   | .| ||. | ...| .    || |||.|.||| |.|||.....   |||| .| |    || .|.|          .
kknrykdvvcndktrvilk..dGydG.dyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGe

YYIVDPIAEHEYPQFVIRDFKVKDARSDTVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRAyeqqeeEGPITVHCSDGVGRTGVFTALFIVLERMRSE
. ..    ...  . . . . |.|  |     .| ..   ||.  |..|   .. ..  ...|       ||..|||| |.|||| |.|. . |. .   
itvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka......sGpvvvhcsaGiGrtGtfvaievglqilldG

GVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYLG
  .|| ..|. ||  | . || . |||   .  |..  
keldlldlvralrnsrlnsvqvdiqylalveilldlGk
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1336-1490 1e-34 114.7 In-house 26-182 (297) alignment 
Range on Protein: 1336-1490
Range on HMM: 26-182/297.0
DSSQMECNKGKNRYPNIHAYDHSRVRLSyiNGIEGSDYINANFCDGY--RKERAYIATQGPMQHTAADFWRMVWEQRTFTIVMLTREEERGRVKCDQYWP
 |.. .    |||| .| |.| .||.|   ..| ..|||||..       ..  || .|||.. |  |||..|.||   .|||... .| || ||  |||
ssakrnsslrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywp

TDGTDVYEGIEVsLVDWVE-----LANYTISTLQICKEgaSQPREVKHFQFTGWPDHGVPAH
    .  .  .| .|...        .  .. ||.     |. | |.| || .|||||||. 
svvqerlkagdv.vveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsd
subfamily_ptpA1_pd Subfamily ptpA1 1587-1825 1.1e-34 114.9 In-house 12-255 (418) alignment 
Range on Protein: 1587-1825
Range on HMM: 12-255/418.0
NLLHHIKKLTELgKGEVTGLEEEfkvVDPSQAKKhkygaATLAINRPKNRLANILPYETTRVHISPVRGVEGSDYINASFIDGYRQRgLFIATQGPLQDT
||  ||| . .. | |.  |||    | ||.. .          |  ||| .|||| . |||..  ..  |||||||| .|||   .  ||.||||| .|
nlknhikcihki.keefrllees...vgpsetse.....gdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk.qfictqgplpnt

VDDFWRMLMEQNSNIIVMLTQLHEGEWEKCYKYWPTDRSArHQYYI------------VDPIAEHEYPQFVIRDFKVKDARSDTVRNIKQFHFLGWPETG
. |||||. |.   |||||..  |    || .||| .     |. |            |. .   . |.  |   ... .     |.| |... |||.  
iadfwrmvwenrcriivmlsresencrikcdrywpeqigg.eqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhn

VPKSGEGIIDLIGQVQRAYEQ----QEEEGPITVHCSDGVGRTGVFTALFIVLER
.|   . . .|.  .    .|     . . || |||| |||||| | .  |....
ipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkk
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1342-1576 7e-34 112.2 In-house 42-271 (288) alignment 
Range on Protein: 1342-1576
Range on HMM: 42-271/288.0
CNKGKNRYPNIHAYDHSRVRLSyingIEGSDYINANFCDGYRKERAYIATQGPMQHTAADFWRMVWEQRTFTIVMLTREEERGRVKCDQYWPTDG---TD
 |  ..|| |.   | .||.||     .   ||.||     . .|  | .| |.. |   .|.|. |.    ||||..  |.|. | ..|.|.     . 
anptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

VYEGIEVSLVDWVELANY-TISTLQICKEGASQPrEVKHFQFTGWPDHGVPAHPTPFLAFLRRVKFYNppdaGPIVVHCSAGVGRTGCFIVIDSMLERLR
.     |  .. ...    ..|.|.| |||  .   ||.  .  |.|.|||    ..| .| ..| ..     |||||.|||||||| .|.|  .|| ||
igrlctvvkkkradidklvkvsllriskegeekv.ivkilhlleWdddgvPenylsplrllevlkslq....kPivvhssaGvGrtgtlililialeslr

HEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAV
 .. . |   .. || .|   .||. ||.. |  .|| .
lddflgirsllaklreerfkaiqtemqylyvhrcvleel
subfamily_CG42327_pd Subfamily CG42327 1322-1502 6.8e-32 105.4 In-house 9-191 (319) alignment 
Range on Protein: 1322-1502
Range on HMM: 9-191/319.0
QEYESIEpgQT-FTADSSQMECnKGKNRYPNIHAYDHSRVRLSYINGIEGSDYINANFCDGYRKE-RAYIATQGPMQHTAADFWRMVWEQRTFTIVMLTR
.|.. .   |    ||   . . | |.|. |.    ..|| |  |   . . |..|..  ||..    |||.| ... ...||||.||||.. .|| || 
eefrdlP..qliaradevPvts.kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltd

EEERGRVKCDQYWPT----DGTDVYEGIEVSLVDWVELANYTISTLQICKEGASQPREVKHFQFtGWPDHGVPAHPTPFLAFLRRVK
  | |  .| .|.||    |.|..|  | |.| .     .| |||| . .   .. ||. |. .  |.. .|||......| | .|.
lselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevr
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1329-1575 1.2e-31 104.7 In-house 25-269 (285) alignment 
Range on Protein: 1329-1575
Range on HMM: 25-269/285.0
PGQTFTAdssqMECNKGKNRYPNIHAYDHSRVRLSYingiEGSDYINANFCDGYRKE-RAYIATQGPMQHTAADFWRMVWEQRTFTIVMLTREEERGRVK
|  |.||     |.|   ||| .... . .|| |         ||| |..     |.  .||.||||.  | .|||.|.....   ..||    | |  |
pnctyta....yeanpdlnryadvrcieetrvvlkn....hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvek

CDQYWPTDGTDV--YEGIEVSLVDWVELA--NYTISTLQ--ICKEGASQPREVKHFQFTGWPDHGVPAHPTPFLAFLRRVKFYNPPDaGPIVVHCSAGVG
|  |.|    .|  .   |..| .  | |     . .|     .. .|.|  ..| |   |||.  |    |.. . . ||  || .  ||.||||||||
calyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpke.kpicvhcsagvg

RTGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEA
||  |. ||    |.  .  ...   |  .|. |   ||.. |..| .  ..| 
rtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmey
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1623-1866 1.9e-30 100.9 In-house 35-271 (288) alignment 
Range on Protein: 1623-1866
Range on HMM: 35-271/288.0
YGAATLAINRPKNRLANILPYETTRVHISpvrgVEGSDYINASFIDGYRQRGLFIATQGPLQDTVDDFWRMLMEQNSNIIVMLTQLHEGEWEKCYKYWPT
  . .   |  ..|  |.   ..|||..|     .   ||.|  .   . .  .| .| ||. |.. .|.||.|.. . ||||..| |   ||  .|.|.
diidsfianptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPs

DRSARHQ--YYIVDPIAEHEYPQFVIRDFKVKDARSDTVRN-IKQFHFLGWPETGVPKSGEGIIDLIGQVqrayeqQEEEGPITVHCSDGVGRTGVFTAL
    . .   .  .   ...  . ...   ..  .    .  .|. |.| |.. |||..    . |.  .      .. . || ||.| |||||| .   
klGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl......kslqkPivvhssaGvGrtgtlili

FIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYL
.|.|| .|..  . . . .. || .|   .|.. |||. ..  ||.|
lialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleel
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1628-1865 2e-30 100.4 In-house 34-268 (281) alignment 
Range on Protein: 1628-1865
Range on HMM: 34-268/281.0
LAINRPKNRLANILPYETTRVHISP-VRGVEGSDYINASFIDGY-RQRGlFIATQGPLQDTVDDFWRMLMEQNSNIIVMLTQLHEGEWEKCYKYWPTDRS
  .|  ||| .||   . .||..   .   . .||| | .|     .|| .| |||| ..|  |||||. ..|.  |||| |. | . ||| .|.| .  
qpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrg.yiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnah

ARHQYYIVDPIAEHEYPQFVIRDFKVKDARSDTVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVqRAyeqqeEEGPITVHCSDGVGRTGVFTALFIVLER
.  |.  .    |    .  .   ... .     | | .. .  ||.  ||.| | .. .. .. ||        |  .||| ||||.| . |. | |. 
cclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrki.ra.....rstppvihcsagvgrsgtlmaveialqs

MRSEG-VVDLFQTVKLLR-TQRPAMVQSQEQYLFCYKTALEY
..|   . |. | |  || | | | ||. .||.. .|  |..
ihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1341-1565 5.5e-30 99.1 In-house 48-270 (301) alignment 
Range on Protein: 1341-1565
Range on HMM: 48-270/301.0
ECNKGKNRYPNIHAYDHSRVRLsYINGIEgsDYINANFCDGYRKERAYIATQGPMQHTAADFWRMVWEQRTFTIVMLTREEERGRVKCDQYWPTDGTDVY
  .| |.|||..    .. |..   .|      | ||. .   . . .||||||.. |. ||| |.      .||||... |.   ||..| |.. ..  
ylpkdkhryptvPckPstavev.ivdGkr..vPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekl

--EGIEVSLVDWVELANYTIS--TLQICK-EGASQPREVKHFQFTGWPDHGVPAHPTPFLAFLRRVKFYNppdaGPIVVHCSAGVGRTGCFIVIDSMLER
  .  .. ...   . |  ||  ||..    |  ..| | |.|.. |.|.|||   .    ..  ||  .     |||||||||.||. .||  . .  .
digrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkkse....kPivvhcsaGiGrsvafigteylare

LRHEETVDIYGHVTVLRTQRNYMVQTQEQY
.  . |...   .  || .|   |||..| 
veadptieltealkhlrehrwngvqtnsql
subfamily_egg_pd Subfamily egg 1337-1573 6.9e-30 98.8 In-house 34-267 (307) alignment 
Range on Protein: 1337-1573
Range on HMM: 34-267/307.0
SSQMECNKGKNRYPNIHAYDHSRVRLSYINGIEGSDYINANFCDGYRKERAYIATQGPMQHTAADFWRMVWEQRTFTIVMLTREEERgrVKCDQYWPTDG
 .  . |. | | . .|  | |||.| . .|    |.| ||  .|      .| .| |.. |  ||||||....   |||||   |    .|. |||   
taasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkae

TDVYEG------IEVSLVDWVELANYTISTLQIcKEGASQPREVKHFQFtGWPDHGVPAHPtpfLAFLRRVKFYnppdAGPIVVHCSAGVGRTGCFIVID
.|          ||   ||      .... |..   |  . | ..|.|   .   .    |   |  ||...      . |.||..  || ...... |.
sdslvtvpGslrienlkvdskadplfrvtklkl.vGgddeerflehwqg.dvnnssdvysp...lrvlrklrnl....skpvvvqdilGvskaatlvaie

SMLERLRHEET--VDIYGHVTVLRTQRNYMVQTQEQYIFSHDAIL
  |  |    .    .   |  || .|.. |..  .|.| .  .|
iallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1662-1856 1.1e-29 98.1 In-house 78-271 (301) alignment 
Range on Protein: 1662-1856
Range on HMM: 78-271/301.0
INASFIDGYRQRGLFIATQGPLQDTVDDFWRMLMEQNSNIIVMLTQLHEGEWEKCYKYWPTDRSARHQ---YYIVDPIAEHE-YPQFVIRDFKVKDARSD
| | .|.   .   ||||||||..| .||| ||.  . . ||||.|  | . ||| .| |.. | . .   . |     |.    . . | ..|.|.  .
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

-TVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRAyeqqeeEGPITVHCSDGVGRTGVFTALFIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYL
 . | .  . .  |.. |||||   . ||.  |...      | || ||||.|.||.  | .  ..  .. ..  ..| ...| || .|   || ..|  
fatrtvthyqysewtdrgvPkshaelfdlmelvkks......ekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqly
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1603-1866 2.6e-29 96.9 In-house 21-287 (305) alignment 
Range on Protein: 1603-1866
Range on HMM: 21-287/305.0
VTGLEEEFKVVDPSqAKKHKYGAATLAINRPKNRLANILPYETTRVHIspvRGVEGSDYINASFIDGYRQRGLFIATQGPLQDTVDDFWRMLMEQNSNII
 .|| .||. .       .|  |   | .. |||  ..   .  ||..   .|    .|| | ..    .   || || ||..|  ||| | .... . |
paglraefvamkrf.ndfekmkafkeaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveai

VMLTQLHEGEWEKCYKYWPTDRSARHQYYI------VDPIAEHEYPQFVIRDFKVK------DARSDTVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVq
 || .| |   .||..|....     ..        |   . ...      . ||.      .    ..| ....|.  ||. ||| .   |..|. .  
fmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelleka.

rayeqQEEEGPITVHCSDGVGRTGVFTALFIVLERMRSEGVVDL-FQTVKLLRTQRPAMVQSQEQYLFCYKTALEYL
     .   |||.|||| |.||||    |  .|... .  ...   . .. .| ||   .|...|||| ..  |.|.
.....rpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1626-1866 1.4e-28 94.5 In-house 50-289 (305) alignment 
Range on Protein: 1626-1866
Range on HMM: 50-289/305.0
ATLAINRPKNRLANILPYETTRVHISPVRgveGSDYINASFIDGYR-QRGLFIATQGPLQDTVDDFWRMLMEQNSNIIVMLTQLHEGEWEKCYKYWPTDR
 .  |.  ||| ...   . . |...       |||| | ..         ||..||||..|.|.|| |..... . |||| .  |    || .|||. .
qsadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaq

SARHQY---YIVDPIAEH----EYPQFVIRDFKVKDArSDTVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRAyeqqeeEGPITVHCSDGVGRTGVFT
  ...     .|. ..        ..  |  ...  .  |    ......  ||. |||      ..|.  .. .      . || |||| |.||||   
geklelksgivvenvsgskpmerdaeiqitllnltys.gdqkmsvrhlqwtewpdrgvppckltslellsairgs......kvpivvhcsagigrtgtiv

ALFIVLERMRSE-GVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYL
|.  .||..  .  .  . . || || ||   .|.. |||| ..  |.|.
aieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
0048076 (Phosphotyrosine protein) phosphatases II 1440-1572 1.3e-27 91.7 In-house 12-139 (145) alignment 
Range on Protein: 1440-1572
Range on HMM: 12-139/145.0
YEGIEVSLVDWVELANYTIST-LQICKEGASQPREVKHFQFTGWPDHGVPAHPTPFLAFLRRVKFYNPPDaGPIVVHCSAGVGRTGCFIVIDSMLErlrh
| |   . .|. .|... | | | .. |     |.. ......|||||||  .  .|.||. .. . . . ||..|||||||||||...... ||.    
ylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll....

eETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAI
 . |...  .  .|.|| ..|....|..| ....
.lgvsleealelvrsqrpgavpnpgqlrflyefe
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1630-1866 1.1e-26 88.5 In-house 34-270 (285) alignment 
Range on Protein: 1630-1866
Range on HMM: 34-270/285.0
INRPKNRLANILPYETTRVHISpvrgVEGSDYINASFIDG-YRQRGLFIATQGPLQDTVDDFWRMLMEQNSNIIVMLTQLHEGEWEKCYKYWPTDRSAR-
 |   || |..   | ||| .         ||| ||..    ...  .|.||||| .|. |||.|. ...   ..||  | ||  |||  |.|       
anpdlnryadvrcieetrvvlk....nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevv

--HQYYIVD-PIAEHEYPQFVIRDFKVKDARSDTVRN--IKQFHFLGWPETGVPKSGEGIIDLIGQVQRAyeqQEEEGPITVHCSDGVGRTGVFTALFIV
   .| |      |      ..  . | ..   .     ... .   ||.   |.    .|.|   |..    . .| || |||| |||||  |  .   
kfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkv...npkekpicvhcsagvgrtatfvgidya

LERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYL
  |.  .  ..... |. .|. |   |||. |.|| |   .||.
tirimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1384-1567 2.5e-26 87.1 In-house 3-195 (199) alignment 
Range on Protein: 1384-1567
Range on HMM: 3-195/199.0
KERAYIATQGPMQHTAADFWRMVWEQRTFTIVMLTREEERGRVKCDQYWPT--DGTDVYEGIEVSLVDWVELANYTISTLQICKEGASQP--REVKHFQF
 .| ||||| |...| ||||.||||  .  |||.  ..    .    ||||   ||  |  . |.    .  ..|||..| .... .. |  ||. |.||
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TGWPDHGVPAHP--TPFLAFLRRV-KFYNPPDAGPIVVHCSAGVGRTGCFIVIDSMLERlrHEE----TVDIYGHVTVLRTQRNYMVQTQEQYIF
| | ..  |       |.   | | | |.     |..|||| | | || |. .|  .    |||     ||..     ||  |  .. . ..| |
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrs..heesktsvvdlfevakrlrqarcgiisslqhynf
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1385-1567 3e-26 86.8 In-house 3-194 (198) alignment 
Range on Protein: 1385-1567
Range on HMM: 3-194/198.0
ERAYIATQGPMQHTAADFWRMVWEQRTFTIVMLTREEERGRVKCDQYWPT--DGTDVYEGIEVSLVDWVELANYTISTLQICKEGASQP--REVKHFQFT
.| ||||| |...| ||||.||||  .  |||.  ..    .    ||||   ||  |  . |.    .  ..|||..| .... .. |  ||. |.|||
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

GWPDHGVPAHP--TPFLAFLRRV-KFYNPPDAGPIVVHCSAGVGRTGCFIVIDSMLERlrHEE----TVDIYGHVTVLRTQRNYMVQTQEQYIF
 | ..  |       |.   | | | |.     |..|||| | | || |. .|  .    |||     ||..     ||  |  .. . ..| |
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrs..heesktsvvdlfevakrlrqarcgiisslqhynf
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1471-1594 3.8e-26 86.4 In-house 88-212 (440) alignment 
Range on Protein: 1471-1594
Range on HMM: 88-212/440.0
PREVKHFQFTGWPDHGVPAHPTPFLAFLRRVKFY-NPPDAGPIVVHCSAGVGRTGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSH
 | .|.... ||||.|||    | | ... |.   .    ||..||||||.||||  |..||.|   .. . .||.  .  .| .|  |||| ||| | |
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvh

DAILEAVSCGNTEVHARNLLHHIKK
.|.||.. ||.| .   .. .....
eavlegllcgdtliledditerveq
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1600-1862 1.1e-25 84.9 In-house 23-286 (310) alignment 
Range on Protein: 1600-1862
Range on HMM: 23-286/310.0
KGEVTGLEEEFKVVDPSQAKKHKYGAATLaiNRPKNRLANILPYETTRVHISpVRGVEGSDYINASFIDGYRQRGLFIATQGPLQDTVDDFWRMLMEQNS
|  . ||  ... .|  |     | | .   .  ||| ....  .|.||..  .      ||| | ..     |  || .||||| |. |||||.... .
klgieglvkqyrkldakqdssltyeaykk..ymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqera

NIIVMLTQLHEGEWEKCYKYWPTDRSARHQYYI-VDPIAEHeYPQFVIRDFKVK--------DARSDTVRN--IKQFHFLGWPETGVPKSGEGIIdligq
. |..| .  |    ||  |||.   .     | |  ..|    .| | .. |         | .   ...  ..  ..  ||..|||      .     
esilllckvgeegrpkcvgywpslgvtetygcirvtnlses.seefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtv.....

VQRAYeQQEEEGPITVHCSDGVGRTGVFTALFIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTA
 ||    |   ||  |||| |..|..| .|| . .....    ||. . .  |. .|   .|.. |||.  .  
pqrll.aqvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvr
0048179 (Phosphotyrosine protein) phosphatases II 1448-1567 2.2e-25 84.5 In-house 20-136 (144) alignment 
Range on Protein: 1448-1567
Range on HMM: 20-136/144.0
VDWVELANY---TISTLQICKEGASQPREVKHFQFTGWPDHGVPAHPTPFLAFLRRVKFYNPPDaGPIVVHCSAGVGRTGCFIVIDSMLerlrhEETVDI
.|. .|...   |. .|.   | ..  ||. ......||||||| ... .|.||. .. . ... ||..|||||||||||...... |.     .. ...
ldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk.....klglsl

YGHVTVLRTQRNYMVQTQEQYIF
.  .  .|..| ..|....|..|
eealalvrsrrpgavpnpgqlrf
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1675-1860 2.9e-25 83.6 In-house 6-198 (199) alignment 
Range on Protein: 1675-1860
Range on HMM: 6-198/199.0
LFIATQGPLQDTVDDFWRMLMEQNSNIIVMLTQLHEGEWEKCYKYWPTDRSARHQYYIVDPI--AEHEYPQFVIRDFKVKDA--RSDTVRNIKQFHFLGW
 .|||| ||..|. |||.|. |  |  |||. .           ||||  |.  .|  .     .    |...|  . . .      . |.| .. |  |
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PETGVPKSG--EGIIDLIGQVQRAYEQqEEEGPITVHCSDGVGRTGVFTALFIVLERM-R-SEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYK
 |   |.     |..    .| . ||| | . |. |||||| | |||| || | .         |||||.  | ||  |  .. | ..| | |.
kekttpnvalfvgfvvasrevskkyeq.ekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1675-1860 3e-25 83.6 In-house 5-197 (198) alignment 
Range on Protein: 1675-1860
Range on HMM: 5-197/198.0
LFIATQGPLQDTVDDFWRMLMEQNSNIIVMLTQLHEGEWEKCYKYWPTDRSARHQYYIVDPI--AEHEYPQFVIRDFKVKDA--RSDTVRNIKQFHFLGW
 .|||| ||..|. |||.|. |  |  |||. .           ||||  |.  .|  .     .    |...|  . . .      . |.| .. |  |
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PETGVPKSG--EGIIDLIGQVQRAYEQqEEEGPITVHCSDGVGRTGVFTALFIVLERM-R-SEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYK
 |   |.     |..    .| . ||| | . |. |||||| | |||| || | .         |||||.  | ||  |  .. | ..| | |.
kekttpnvalfvgfvvasrevskkyeq.ekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_CG42327_pd Subfamily CG42327 1631-1792 7.8e-25 82.2 In-house 28-193 (319) alignment 
Range on Protein: 1631-1792
Range on HMM: 28-193/319.0
NRPKNRLANILPYETTRVHISPVRGVEGSDYINASFIDGYRQ-RGLFIATQGPLQDTVDDFWRMLMEQNSNIIVMLTQLHEGEWEKCYKYWPTDRSA-RH
 ..|.|..|..|   |||    .   . . |..||.. ||.. .  .||.| .|.|.  ||||.. ||.| .|| ||.|.|   ..| .|.||  .   .
skdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnt

QYY---IVDPIAEHEYPQFVIRDFKVKDARSDTVRNIKQFHFlGWPETGVPKSGEGIIDLIGQVQRA
. |    |         ...|  . .|    .  |..  . .  |.|..|| . . .| .. .|. .
slyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
subfamily_egg_pd Subfamily egg 1603-1863 5.9e-24 79.3 In-house 13-267 (307) alignment 
Range on Protein: 1603-1863
Range on HMM: 13-267/307.0
VTGLEEEFKVVDPSQaKKHKYGAATLAINRPKNRLANILPYETTRVHISPVRGVEGSDYINASFIDGYRQRGLFIATQGPLQDTVDDFWRMLMEQNSNII
| .||  ..|.. |  ..  .  |  . |. | |   .   ...||..   ||    |.| |  ..|      || .| ||..||||||||..... . |
vqelerrlevleesv.deislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyi

VMLTQLHEGewEKCYKYWPTDRSARHQY----YIVDP--IAEHEYPQFVIRDFKVkdARSDtvrniKQFHFLGWPETGVPKSGEGIIDLigQVQRAYEQq
||||   |   |.|  |||   |   ..    . ..   . ..  | | .  .|.    .|     ..  ||   .  | .|..    |  .| |   . 
vmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklkl..vGgd.....deerflehwqgdvnnssdvyspl..rvlrklrn.

eEEGPITVHCSDGVGRTGVFTALFIVLERM-RSeGV--VDLFQTVKLLRTQRPAMVQSQEQYLFCYKTAL
    |. |.. .|| ..... |. | |  . |   .    . ..|..|| .|.  |.|  .||| |.  |
.lskpvvvqdilGvskaatlvaieiallsllrG.pitkslvlravvflrlrrrlsvesvllylfvyrlvl
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1398-1576 1.2e-23 78.5 In-house 40-221 (255) alignment 
Range on Protein: 1398-1576
Range on HMM: 40-221/255.0
TAADFWRMVWEQRTFTIVMLTREEERGRVKCDQYWPT--DGTDVYEGIEVSLVDwvELANYTISTLQICKEGA--SQPREVKHFQFTGWPDHGVPAHPTP
| . |....  ..| ..|||.  .| |..||..|.|.  |.  ... ..|.  .    |.  . ||.|  . .   . ..|||....||...  |  .  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

FLAFLRRVKfynppDAGPIVVHCSAGVGRTGCFIVIDSML----ERLRHEETVDI--YGHVTVLRTQRNYMVQTQEQYIFSHDAILEAV
 |  |. |.     |. ..|||||.|.||.  |......       |.  |||..     .. || .|.  ..|  |  ||   .|. |
ilnilkvvr.....dsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1633-1723 2.2e-23 77.5 In-house 49-153 (350) alignment 
Range on Protein: 1633-1723
Range on HMM: 49-153/350.0
PKNRLANILPYETTRVHIS----P----VRGVEGSDYINASFIDGY----RQRGLF--IATQGPLQDTVDDFWRMLMEQNSNIIVMLTQLHEGEWEKCYK
 |||  |||||| .||..     .       ....|||||...       ..   |  ||||.||. |||||...... . ..|..||.. | . ||||.
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPTD
||.  
YWqeg
0048076 (Phosphotyrosine protein) phosphatases II 1753-1865 9.4e-23 75.9 In-house 38-142 (145) alignment 
Range on Protein: 1753-1865
Range on HMM: 38-142/145.0
DARSDTVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRAYEQQeeeGPITVHCSDGVGRTGVFTALFIVLErmrsEGvVDLFQTVKLLRTQRPAMVQSQ
. ... .|.. |...|.||  ||| . | ..... ....|...    ||. |||| ||||||.. |....|.    .| |.|.....|.|.||| .|...
selellerlgiqylylpwpDhgvpdllellleflefieealkeg...gpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqrpgavpnp

EQYLFCYKTALEY
.|. |.|.  ||.
gqlrflyefelel
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1345-1447 2e-22 74.4 In-house 49-162 (350) alignment 
Range on Protein: 1345-1447
Range on HMM: 49-162/350.0
GKNRYPNIHAYDHSRVRLS--------YINGIEGSDYINANFCDGY----RKERA--YIATQGPMQHTAADFWRMVWEQRTFTIVMLTREEERGRVKCDQ
 |||| ||  |.||||.|             ....||||||.        . .    |||||.|.. |  ||.... .     |..|| . | .. ||..
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPTDGtdvYEGIEVSL
||.  .   |..| | |
YWqegs...ydditvkl
0048179 (Phosphotyrosine protein) phosphatases II 1747-1860 3.4e-22 74.1 In-house 48-139 (144) alignment 
Range on Protein: 1747-1860
Range on HMM: 48-139/144.0
RdfkvkdarsdtvrnIKQFHFLGWPETGVPKSGEGIIDLIGQVQRAYEqqeEEGPITVHCSDGVGRTGVFTALFivleRMRSEGvVDLFQTVKLLRTQRP
               . |...|.||  ||| . | .....  ...|.|   |.||. |||| ||||||.. |..    .|. .| ..|.....|.|..||
e..............giqylhlpwpDhgvpdllellleflefieeale...eggpvlVHCsaGvgRtgtlvaay....lmkklg.lsleealalvrsrrp

AMVQSQEQYLFCYK
 .|....|. |...
gavpnpgqlrfLle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1759-1867 2.6e-21 70.5 In-house 88-195 (440) alignment 
Range on Protein: 1759-1867
Range on HMM: 88-195/440.0
VRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRAYEQQeEEGPITVHCSDGVGRTGVFTALFIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFC
 | .||.|. |||. ||||    .. .| .|. . |.   .||. |||| |.|||||  |.  .|   .    .|.|  .. .| .|| |||. ||| | 
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqeka.gngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

YKTALEYLG
... || | 
heavlegll
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1316-1572 8.9e-20 65.3 In-house 24-281 (302) alignment 
Range on Protein: 1316-1572
Range on HMM: 24-281/302.0
NNSQFTQEYESIEPGQTFTADSSQMECNKGKNRYPNIHAYDHSRVRLSyingIEGSDYINANFCDGYRKERAYIATQGPMQHTA---ADFWRMVWEQRTF
.... ..|...|.  .. .   .    |  ||. ... ..|. .|.|.     |  .|.||   .    .|  | .| | . ..   ..|||||....  
dtaevkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkle....aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekiv

TIVMLTREEERGRvKCDQYWP--TDGTDVYEGIEVSLVDwVELANY--TISTLQICKEGASQPREVKHFQFTGWPDHGVPAHPTPFLAFLRRVKFYNPPD
..|.| .|||  .   ....|  ..    |. . |     || |.   |  .. .  || |.   ..   .| |... || . .   .    |   . . 
svvilvgeeelkk.tlselfpkksgdykeygkmfvNnrk.VekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkika

AGPIVVHCSAGVGRTGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAI
  ..|.    |.|| | |..    .|.| ... . |   |. .|.||  .|.. .||.. . |.
dentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyial
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1634-1870 3.8e-19 63.5 In-house 46-280 (312) alignment 
Range on Protein: 1634-1870
Range on HMM: 46-280/312.0
KNRLANILPYETTRVHISpvrGVEgSDYINASFIDGYRQRGLFIATQGPLQDTVDDFWRMLMEQNSNIIVMLTQLHEGEWEKCYKYWPTDR----SARHQ
 ||  ||  ..  |  ..   | |   || | |.    .   |..|||||..|.  ||.. .   |  |..|. . |   ||| ||            |.
lnrypniqcwdrgrftla...gde.nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhr

YY----IVDPIAEHEYPQFVIRDFKVKDARSDTVRNIKQFHFLGWPETGVPKSGEGIIDLIGQVQRayeqqeEEGPITVHCSDGVGRTGVFTALFIV---
 |        |  .   .   | .||    .    ..... .  ||. |.| | .    |.  |..      .  |.  ||| |||||| .. .  .   
vyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkk......dkkpviahcsagvgrtgtlaliesmiaa

LERMRSEGVVDLFqtvKLLRTQRPAMVQSQEQYLFCYKTALEYLGSFD
|   | . | | |    ||| .|   |.   ||... .. ||.| |  
lrhprkqnvkdsf...vllrkdrarsvrvfpqyvyalrcvleflyskg
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1336-1576 5.4e-19 62.9 In-house 40-279 (303) alignment 
Range on Protein: 1336-1576
Range on HMM: 40-279/303.0
DSSQMECNKGKNRYPNIHAYDHSRVRLSyingieGSDYINANFCDGYRKERAyIATQGPMQHTAADFWRMVWEQRTFTIVMLTREEERGRVKCDQYWPTD
   |.  |  |||. ..   |||.|.||       | || |.. .   . .| | || |..|||||||.|. ||.   ...|  . |  ..  |  .| .
sknqfvknmdknrfvdvicldhskvkls......dssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprn

GTDV-YE--GIEVSLVDWVELAN-YTISTLQICKEGASQPREVKHfqFTGWPDHGVPAHPTP-FLAFLRRVKFY--NPPDAGPIVVHCSAGVGRTGCFIV
   . .|   | |     |||.. ...  | . .        |.|  .  ||   .|.. .| |.  . ... .  .  |. | |    .|.||.| | .
qdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhh..ykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfal

IDSMLERLRHE-ETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAV
...    |  |  ..|.   .  .|  | . ||   |. . .  . | |
fetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehv
subfamily_hpo-7_pd Subfamily hpo-7 1397-1581 5.5e-19 63.1 In-house 45-232 (263) alignment 
Range on Protein: 1397-1581
Range on HMM: 45-232/263.0
HTAADFWRMVWEQRTFTIVMLTREEERGRVKCDQYWPT--DGTDVYEGIEVSLVDWVElaNYTISTLQICK---EgASQPREVKHFQFTGWPDHGVPAHP
 | . |....  ..| ..|||.  .| |..||..|.|.  |.  ... ..|.  . ..  .  . ||.. .   |   . ..|||....||...  |  .
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlge.KkkthtvkhysykgWiekndpela

TPFLAFLRRVKfynppDAGPIVVHCSAGVGRTGCFIVIDSM----LERLRHEETVDI--YGHVTVLRTQRNYMVQTQEQYIFSHDAILEAVSCGNT
   |  |. ..     .  ..|||||.|.||.  | |....    .  |.  .||..     .. || .|.  ..|  |  ||   .|. |   ..
reilnilkvar.....nskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfa
fn3 Fibronectin type III domain 575-660 6.9e-19 61.0 Pfam-A 1-85 (85) alignment 
Range on Protein: 575-660
Range on HMM: 1-85/85.0
DAPQNIQGRSRDSTTLEISWDPPRpeHRNGLITHFTIKYRAKGQRG-AKYLTVDATKTSVVLHNLDKFTNYFIWVQASTKQGDGPFS
.||.|.. ... ||.|..||.||.  ...| ||.....|| ||. .  |  ||..|.|||.|..|   |.| ..||| ...| ||.|
saPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1391-1567 1.4e-18 61.4 In-house 96-279 (302) alignment 
Range on Protein: 1391-1567
Range on HMM: 96-279/302.0
TQGPMQHTAADFWRMVWEQRTFTIVMLTREEERGRVKCDQYWPTDGTDVYE---------GIEVSLVDWVELANYTISTLQICK--EGASQPREVKHFQF
   | . |   .| .. . ..  .| |.   | .  || .|. ..  .. .          ..  | .. .  .... |..|        ... |. ..|
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf

TGWPDHGVPAHPTPFLAFLRRVKFYNppdaGPIVVHCSAGVGRTGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIF
..||||| |... . |  |.  . |       ..||||||||||| .. |   ..   .... |.   |. .|. |   ||...| |.
sawpdhGapkeaytaldilkfcesyk....knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliy
fn3 Fibronectin type III domain 675-767 6.9e-18 57.8 Pfam-A 2-85 (85) alignment 
Range on Protein: 675-767
Range on HMM: 2-85/85.0
APRDVRIRVHNSTTMTVKWNPPTtKQDGKILGYMVFYTRVDDQGnqlrppaqPESKDSMSEENHKVHLTGLAPETTYQIEVAAYTIKGDGARS
||......  .||..|..|.||. ...|.| || | |  .....        ..   . ..  . |.|||| | |.|...|.|.. .| | .|
aPenlsvsevtstsltlsWsppk.dgggpitgYeveyrekggge........ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_CG42327_pd Subfamily CG42327 1787-1865 9.1e-18 59.0 In-house 235-314 (319) alignment 
Range on Protein: 1787-1865
Range on HMM: 235-314/319.0
GQVQRAYEQQEEEGPITVHCSDGVGRTGVFTALFIVLERMRSE-GVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEY
|..     ..|. ||..|||||||||||.  |  | ....      ||. |.|  .| .|   |...||| | ||.. ||
gnissrsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1327-1487 1.6e-17 57.9 In-house 81-235 (244) alignment 
Range on Protein: 1327-1487
Range on HMM: 81-235/244.0
IEPGQTFTADSSQmECNKGKNRYPNIHAYDHSRVRLSyiNGIEGSDYINANFCDGYRKERAYIATQGPMQHTAADFWRMVWEQRTFTIVMLTREEERgrv
| |  .   |. .   |  |||      .| .|| ||  .|  |  |||| |     .   || || |.  |. |||.|. |.    .|.|   ||    
irpdpsvmkdafn.pnnswknregaglpfdfnrvpls..kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee...

kcDQYWPT-DGTDVYE-GIEVSLVDWVELANYTISTLQICKEGASQPREVKHFQFTGWPDHGV
  |.|||  .  . ||  | |.| |  |. |   | |.|  .     . .  || . ||  | 
..deywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgt
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1512-1579 2e-17 57.3 In-house 1-68 (69) alignment 
Range on Protein: 1512-1579
Range on HMM: 1-68/69.0
IVVHCSAGVGRTGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAVSCG
.|||||.| |||| || |   . |.. |  |||.  |  .|  |  ||  . .||| |||. ||.  |
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1465-1573 2.4e-17 57.7 In-house 208-341 (350) alignment 
Range on Protein: 1465-1573
Range on HMM: 208-341/350.0
KEGASQPREVKHFQFTGWPDHGVPAHPTPFLAFLR----------RVKFYNPPDAGPIVVHCSAGVGRTGCFIVIDSMLE----------RLRH----EE
.  ||.| .| ..|.  |.| ..  .|  .|  |             ....   . ||.||||||||||| .. .||.|.          . |.     .
tlaasdPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaak

TVD-IYGHVTVLRTQRNYMVQTQEQYIFSHDAIL
| | |   |  || ||  |||. .|.|| ..|.|
trDlisiivnelrkqrismvqnldqfifiYeall
fn3 Fibronectin type III domain 288-368 2.9e-17 55.8 Pfam-A 2-85 (85) alignment 
Range on Protein: 288-368
Range on HMM: 2-85/85.0
APSRPNAASITSDAIKITWHPR--GAHVVTSYEVQYRLKGKTE-WQEITNVRGMQSLVVSGLRPFSSYEFRVFAVNSLGRSRPS
||..... ..||. . ..| |   |   .|.|||.|| ||..| |.|.|. |  .|....||.| ..||||| |||  | ...|
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
I-set Immunoglobulin I-set domain 102-183 5.4e-17 53.4 Pfam-A 1-83 (90) alignment 
Range on Protein: 102-183
Range on HMM: 1-83/90.0
PRIAKHPSFKQRRSGDDVTFTCAAVGTPTPNITWFKDRLPIVLnDPRVSVLSDG--RKLRITDLRESDNGKYSCVARNALGMVF
|.. ....  . . |..|...| . |.|.|...|.||  ..   . ||.|  ..   .|.|.. ..||.|||.|.|.| .| . 
pkftqklkdvevseGesvelectveGepepsvsWakdgselks.sqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagkae
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1686-1866 6e-17 56.6 In-house 40-221 (255) alignment 
Range on Protein: 1686-1866
Range on HMM: 40-221/255.0
TVDDFWRMLMEQNSNIIVMLTQLHEGEWEKCYKYWPTDRSARHQYYIVDPIAEHEYPQFVIRDFKVKDARS--DTVRNIKQFHFLGWPETGVPKSGEGII
||| |..... .... .|||. ..| . ||| .|.|...  . ..  |. .. .   . |.|  ..    .     ...| ... ||.|   |.  . | 
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

DLIGQVQRAyeQqeeegPITVHCSDGVGRTGVFTALFIVLER----MR--SEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYL
 ..  |. .  .     .. |||| |.||.  |    .|  .    ..  . . .|  . .. || .|.. ..   |  |.  . |...
nilkvvrds..k.....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1513-1579 9.8e-17 55.1 In-house 1-67 (69) alignment 
Range on Protein: 1513-1579
Range on HMM: 1-67/69.0
VVHCSAGVGRTGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAVSCG
|||||.| |||| || |   . |.. |  |||.  |  .|  |  ||  ...|.| |||. ||.  |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1644-1859 1.2e-16 55.7 In-house 31-252 (290) alignment 
Range on Protein: 1644-1859
Range on HMM: 31-252/290.0
ETTRVHISPVRGVEGSDYINASFIDgYRQRGLFIATQGPLQDT-------VDDFWRMLMEQNSNIIVMLTQLHEGEWE----KCYKYWPTD--RSARHQY
| ||| .        .||| |...  . .   .|.|| |....       . .|| | .. ... .||| . .| . .     | || |.    . . . 
eatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkg

YIVDPIAEHEYPQFVIRDFKVKDARSDTVrNIKQFHFLGWPETGVPKSGEGIIDLIGQVQrAyeqqeEEGPITVHCSDGVGRTGVFTALFIVLERMR-SE
  |      .  .. .|   ||         ..   . || .. |...   ...|| .|. |     .. |. ||| ||. |  ...|. .    .  ..
ltvkCkskekeddvetRelvvkfddeeef.tvtHsllkgWnklnvqedtktllsliqkvk.a.....sktpvivHcvdGiSrsAalaaiilgyQkiaets

GVVDLFQTVKLLRTQRPAMVQSQEQYLFCY
| | | . .| || ||  ...|.... |  
gsvkledvlkalrkqralaitsalelafvd
subfamily_eak_pd Subfamily eak 1351-1501 1.3e-16 54.9 In-house 59-207 (332) alignment 
Range on Protein: 1351-1501
Range on HMM: 59-207/332.0
NIHAYDHSRVRLSYINgIEGSDYINANFCDGYRKERAYIATQGPMQHTAADFWRMVWEQRTFTIVMLTREEERGRVKCDQYWPTDGTDV--YEGIEVSLV
.|  ||.  |||.     .   ||||   .     | || |  . .     ||.|| ||.. .||.|  . | .  | |.|.| .. ..  .  ..|   
kivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverk

DWVELANYTISTLQICKeGAsQPREVKHFQFTGWPDHGVPAHpTPFLAFLRRV
..|. ...    |.. | |  .  .|.|... || .  .|     |||. . .
efvkrniletrllelsk.Gn.ethrvlhykvfGwtettlpky.edflalrkvm
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1681-1857 2.1e-16 54.3 In-house 98-279 (302) alignment 
Range on Protein: 1681-1857
Range on HMM: 98-279/302.0
GPLQDTVDDFWRMLMEQNSNIIVMLTQLHEGEWEKCYKYWPTDRS--ARHQYYIVDPIA-EHEYPQFV------IRDFKVKD--ARSDTVRNIKQFHFLG
 | ..|.. .| .. . |  |.| |... |.| .|| .|. ..     . . | |  .  ...  .|       .   ..|.   .... . .. ..| .
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPETGVPKSGEGIIDLIGQVqRAYEQQeeegpITVHCSDGVGRTGVFTALFIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLF
||. | ||  .  .|..     .| ..     . |||| |||||| . |.   ..    . | || . |. .|. |   ||...| ..
wpdhGapkeaytaldilkfc.esykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliy
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1356-1573 4.3e-16 53.9 In-house 31-256 (290) alignment 
Range on Protein: 1356-1573
Range on HMM: 31-256/290.0
DHSRVRLSYINGIEGSDYINANFCDgYRKERAYIATQGPMQHT-------AADFWRMVWEQRTFTIVMLTREEERGRV----KCDQYWPTD--GTDVYEG
 ..|| |        .||| ||.   . .  . |.|| | ...         .|| |. . .   .|||   ||. .      | .| |.   .   ..|
eatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkg

IEVSLVDWVELANYTISTLQICKEGaSQPREVKHFQFTGWPDHGVPAHPTPFLAFLRRVKFYnppdAGPIVVHCSAGVGRTGCFIVIDSMLERLR-HEET
..|.  . ..  .  . .| .  ..  ..  |.| .. || .  |. ..  .|. .. || .      |..|||  |. |  ..  |.     .   .. 
ltvkCkskekeddvetRelvvkfdd.eeeftvtHsllkgWnklnvqedtktllsliqkvkas....ktpvivHcvdGiSrsAalaaiilgyQkiaetsgs

VDIYGHVTVLRTQRNYMVQTQEQYIFSHDAIL
| .   . .|| ||. ........ |   .|.
vkledvlkalrkqralaitsalelafvdagiv
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1602-1865 7.1e-16 52.5 In-house 24-284 (302) alignment 
Range on Protein: 1602-1865
Range on HMM: 24-284/302.0
EVTGLEEEFKVVDPSQAKKHKygAATLAINRPKNRLANILPYETTRVHISpvrgVEGSDYINASFIDGYRQRGLFIATQGPLQDTV---DDFWRMLMEQN
. . ...||| .|  ...  |    .   |  ||.  ..  .....| ..     |  .|.||| ..    .   | .| | .|..   ..|||| ....
dtaevkkefkkidtmkvdlek..Ckafkknlkknqsedvpildsnlvkle....aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqek

SNIIVMLTQLHEGEWeKCYKYWPT---DRSARHQYYI----VDPIAEHEyPQFVIRDFkVKDARSDTVRNIKQFHFlgWPETGVPKSGEGIIDLIGQVqr
   .|.| .  | .     ...|.   | .   . ..    |.   |..  ..||  .  ..     . |.. ...  |... ||..   .|  . .|  
ivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvl.Pegcsnsvlanvyvltn..Wkqkkvpvkyaeliktaakv..

aY-EQQEEEGPITVHCSDGVGRTGVFTALFIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEY
 . .... . .. .    |.|| |.| .|....|.. ..  .   ..|| .|.|||..|.| .|| . | ..| |
.fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiallly
fn3 Fibronectin type III domain 885-970 8.3e-16 51.1 Pfam-A 2-84 (85) alignment 
Range on Protein: 885-970
Range on HMM: 2-84/85.0
PPLNVRAVAVSSTSVEVTWSAPDiwNRGGPILGYSVMYNPANKRGDVTVKNVTSPNIfKVVLKRLKKFREYEVRVRAIGMLGMGPA
.| |... .|.|||....||.|.  ..|||| ||.| | .... .. . ..|...    |.|. ||  .|||.||.|.   | ||.
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavngagegpe
subfamily_eak_pd Subfamily eak 1617-1778 1.2e-15 51.8 In-house 40-197 (332) alignment 
Range on Protein: 1617-1778
Range on HMM: 40-197/332.0
QAKKHKYGAATLAINRpkNrLANILPYETTRVHISPVRgVEGSDYINASFIDGYRQRGLFIATQGPLQDTVDDFWRMLMEQNSNIIVMLTQLHEGEWEKC
...  . .| . |.||  | . .|.||.   |.... .  .   ||||| ..       .| |  . .| |  ||.|..||.|  ||.| .  | . || 
rllsisetarleavnr..n.vvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleks

YKYWPTDRSARHQYYIVDpIAEHEY---PQFVIRDFKVKDArsDTVRNIKQFHFLGWPETGVPKS
 ||.| .     .. |.| .   |.    ..  | ....    .   ... ... || || .|| 
dkyfpdktreelkfGild.verkefvkrniletrllelskG..nethrvlhykvfGwtettlpky
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1803-1864 2.7e-15 50.5 In-house 2-63 (69) alignment 
Range on Protein: 1803-1864
Range on HMM: 2-63/69.0
TVHCSDGVGRTGVFTALFIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALE
 |||| | |||| | |... . |..|| .||.|  |. .|  || ||  . .|.| . .  |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalve
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1804-1864 5.1e-15 49.6 In-house 2-62 (69) alignment 
Range on Protein: 1804-1864
Range on HMM: 2-62/69.0
VHCSDGVGRTGVFTALFIVLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALE
|||| | |||| | |. . . |..|| .||.|  |. .|  || ||  ...|.| . .  |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalve
subfamily_hpo-7_pd Subfamily hpo-7 1683-1865 7.3e-15 49.6 In-house 43-226 (263) alignment 
Range on Protein: 1683-1865
Range on HMM: 43-226/263.0
LQDTVDDFWRMLMEQNSNIIVMLTQLHEGEWEKCYKYWPTDRSARHQYYIVDPIAEHEYPQFVIRDFKVKDARS--DTVRNIKQFHFLGWPETGVPKSGE
| .|.| |....  .... .|||.  .| . ||| .|.|...  . ..  |.  . .   . ...  ..    .   .....|.. . ||.|.  |.  .
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelar

GIIDLIgQVQRAYeQqeeegPITVHCSDGVGRTGVFTALFIVLERM----R--SEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALEY
 |. .. .| |   .     .. |||| |.||.  |.   .|  .|    .  | . .|  . .. || .|.. ..   |  |   . |..
eilnil.kvarns.k.....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdf
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1507-1576 8.8e-15 49.3 In-house 226-295 (297) alignment 
Range on Protein: 1507-1576
Range on HMM: 226-295/297.0
PDAGPIVVHCSAGVGRTGCFIVIDSMLERLRHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAV
|   ...|||||||||.|  .  | .|..||..   |.   ...|| ||  .||| ||. . .||.|. .
prnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1632-1722 1.4e-14 48.3 In-house 97-180 (244) alignment 
Range on Protein: 1632-1722
Range on HMM: 97-180/244.0
RPKNRLANILPYETTRVHISpvRGVEGSDYINASFIDGYRQRGLFIATQGPLQDTVDDFWRMLMEQNSNIIVMLTQLHEGEwekcyKYWPT
  ||| .  ||..  || .|  .|  |  ||||||.    .   .| || || ||  |||.|..|.  |..|.|  . | .     .||| 
swknregaglpfdfnrvpls..kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed.....eywpd
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1762-1865 1.4e-14 48.6 In-house 217-343 (350) alignment 
Range on Protein: 1762-1865
Range on HMM: 217-343/350.0
IKQFHFLGWPETGVPKSGEGIIDLIG--------QVQRAYEQQEEEGPITVHCSDGVGRTGVFTALFIVLE------RMR--------SEGVVDL-FQTV
. |...  |.. ..    | |.  .          . . . ....  || |||| ||||||.. .|  .|.       ..           . || ...|
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

KLLRTQRPAMVQSQEQYLFCYKTALEY
. || ||  |||. .|..|.|...| |
nelrkqrismvqnldqfifiYeallfy
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1629-1863 1.5e-14 48.3 In-house 45-276 (303) alignment 
Range on Protein: 1629-1863
Range on HMM: 45-276/303.0
AINRPKNRLANILPYETTRVHISpvrgveGSDYINASFIDGYRQRGlFIATQGPLQDTVDDFWRMLMEQNSNIIVMLtqLHEGEWEKCYKYWPTDRSARH
  |  |||.....  . ..|..|       | || ||...   ..   | || ||. |  |||.|..||. . ...|  | ..|..|        |    
vknmdknrfvdvicldhskvkls......dssyihasyleldsskk.ailtqlplshtaadfwqmiieqkvkcvlll..ltdseydklggdsvfprnqdf

QYYIVDPIAEHEYPQFVIRDF---KVKDARSDTV-RNIKQFHFLGWPETGVPKSG-EGIIDLIGQVQRAYEQQEEEGPITVHCSDGVGRTGVFTALFIVL
  .    |   |. .  . |    ||      .    ..  |.  || . .|  |   ..  | |.|    .  .  |       |.||.| |. .    
lkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetah

ERMRSE-GVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTAL
  . ||   .|| . .. .|  |   ||   |. . |    
lslhseqasldlvkclenvrngrlhavqnlsqfsvvytlla
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1299-1393 2.1e-14 47.5 In-house 4-95 (95) alignment 
Range on Protein: 1299-1393
Range on HMM: 4-95/95.0
PISVLDLPKHIAILKADNNSQFTQEYESIE--PGQTFTADSSqmECNKGKNRYPNIHAYDHSRVRLSYingIEGSDYINANFCDGYRKERAYIATQG
|| |  .  |.  .... . .| .|. ||    | ..|. ||  |.|  |||. ||  || .|| |.       |||||| | ||| .  .|||.||
pihvsvfhshvlemhsnsdqefdnefksismtsgapytvgss..eanipknrflnifpydatrvvltt...krdsdyinacfvdgyarkncyiaaqg
subfamily_CG42327_pd Subfamily CG42327 1509-1569 4.3e-14 46.9 In-house 247-308 (319) alignment 
Range on Protein: 1509-1569
Range on HMM: 247-308/319.0
AGPIVVHCSAGVGRTGCFIVIDSMLERLRHE-ETVDIYGHVTVLRTQRNYMVQTQEQYIFSH
 ||.||||| ||||||  |  |  ...| .  ..|||   |  .| .|   |.|.||| | .
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiy
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1340-1427 7.8e-14 45.9 In-house 31-117 (332) alignment 
Range on Protein: 1340-1427
Range on HMM: 31-117/332.0
MECNKGKNRYPNIHAYDHSRVRLSYINGIEgsDYINANFCDGYRKERAYIATQGPM-QHTAADFWRMVWEQRTFTIVMLTREEERGRVK
.  |   || | ....||||| |.  .| .  |. ||.. ||| |. ||| .| |. .||   ||||| |..   |...   .|. . |
flnnmdmnriphlycfdhsrvelapqdgkd..dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1345-1448 9.1e-14 45.5 In-house 50-166 (349) alignment 
Range on Protein: 1345-1448
Range on HMM: 50-166/349.0
GKNRYPNIHAYDHSRVRLSY----INGIE----------GSDYINANFCDG--YRKERAYIATQGPMQHTAADFWRMVWEQRTFTIVMLTREEERGRVKC
 |||| .|  |.||||.|       ..|.            ||||||.     .  |. ||||| |.  |  ||....  ..   .. |. ..| .  ||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

DQYWPTdgtDVYEGIEVSLV
|.||       |..|.| | 
diywqe...lsysnitvklq
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1606-1681 1.5e-13 44.8 In-house 25-95 (95) alignment 
Range on Protein: 1606-1681
Range on HMM: 25-95/95.0
LEEEFKVVDPSQakKHKYGAATLAINRPKNRLANILPYETTRVHISPVRgveGSDYINASFIDGYRQRGLFIATQG
...||| .  .      | . .   | ||||. ||.||..||| ..  |    |||||| |.||| ..  .||.||
fdnefksismts..gapytvgsseanipknrflnifpydatrvvlttkr...dsdyinacfvdgyarkncyiaaqg
fn3 Fibronectin type III domain 382-466 2.5e-13 43.1 Pfam-A 1-85 (85) alignment 
Range on Protein: 382-466
Range on HMM: 1-85/85.0
SAPRNIEAMGVSDTSFKAGWLPPISANGRIRGYRLYYSLDLLEDISQWRFMASSTNSTTVTGLTRQTTHFFRILAYNIAGDGPLS
|||.|. . .|..||.   | || . .| | ||.. |. .  .. ....   ..|.| |.|||.  |.  ||. |.| || || |
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
fn3 Fibronectin type III domain 480-561 2.9e-13 43.0 Pfam-A 2-85 (85) alignment 
Range on Protein: 480-561
Range on HMM: 2-85/85.0
QPRSVQLSVLSSTAIRVTWSPPRYPGDGIFGYDVYYN-KSKQD-MDTVIGAFQMNTKEIMGLTPYTVYKVAVAAKSDKGVGPMS
.|. ...|  .|| ....||||. .|. | ||.| |  |....   ..    . .. .. ||.|.| |.. |.| ...| || |
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1361-1487 3.8e-13 43.9 In-house 11-126 (130) alignment 
Range on Protein: 1361-1487
Range on HMM: 11-126/130.0
RlsyingieGSDYINANFCDGYRKERAYIATQGPMQHTAADFWRMVWEQRTFTIVMLTREEERgrvkcDQYWPT-DGTDVYE-GIEVSLVDWVELANYTI
.        | .||||.|     . . |. || |.  |. |||.|. |.    .|.|   ||      |.|||  .  . ||  | |.| |  |  |   
q........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdrdefknika

STLQICKEGASQPREVKHFQFTGWPDHGV
| |.| ..     . .  || . ||  | 
snleiesdlneshqaltmfqisnwpsdgt
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1634-1722 3.4e-12 40.4 In-house 51-155 (349) alignment 
Range on Protein: 1634-1722
Range on HMM: 51-155/349.0
KNRLANILPYETTRVHIS----PVRGVEG----------SDYINASFIDGYR--QRGLFIATQGPLQDTVDDFWRMLMEQNSNIIVMLTQLHEGEWEKCY
|||  .||||| .|| .     . ....            ||||| ..   |      .|||| ||  |||||..... .. .... |.. .| . |||.
knrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcd

KYWPT
.||  
iywqe
I-set Immunoglobulin I-set domain 205-282 6.5e-11 33.9 Pfam-A 1-90 (90) alignment 
Range on Protein: 205-282
Range on HMM: 1-90/90.0
PEFTLRPQDKTVDPDTDVELKCSARGSPTPSIVWEVDGSRISG----------QNGELIIRGIQR--SGNYSCIADSNMGRVQAYAYVTV
|.|| ...| .|  ...|||.|...|.|.||. |  ||| ..           .. .|.|. ...  .|.|.| |  ..|...| | ..|
pkftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1641-1723 9.5e-11 36.1 In-house 3-72 (130) alignment 
Range on Protein: 1641-1723
Range on HMM: 3-72/130.0
LPYETTRVHispvrgveGSDYINASFIDGYRQRGLFIATQGPLQDTVDDFWRMLMEQNSNIIVMLTQLHEGEwekcyKYWPTD
|..| .|..        | .||||||.    .   .. || || ||  |||.|..|.  |..|.|  . | .     .|||  
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed.....eywpds
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1380-1439 1.5e-10 35.0 In-house 230-286 (440) alignment 
Range on Protein: 1380-1439
Range on HMM: 230-286/440.0
DGYRKERAYIATQGPMQHTAADFWRMVWEQRTFTIVMLTREEERgrvKCDQYWPTDGTDV
.|| |  |.|||| |.. |  ||||.| . |  ||.|| . ...    |  ||| .   |
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsv
Ig_2 Immunoglobulin domain 111-179 1.7e-10 32.8 Pfam-A 9-69 (80) alignment 
Range on Protein: 111-179
Range on HMM: 9-69/80.0
KQRRSGDDVTFTCAAVGTPTPNITWFKDrlpivlnDprvSVLSDGRK-LRITDLRESDNGKYSCVARN-AL
 . . |..||.||.| | |||...| ||       .   . || ... | |  . ..|.|.|.|.|.|  .
tvvtegenvtLtCqapgnptpkvqwykd.......g...eelsqsqnalfipnvsaedsGtYtCrasnseg
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1316-1381 2e-10 34.6 In-house 20-85 (440) alignment 
Range on Protein: 1316-1381
Range on HMM: 20-85/440.0
NNSQFTQEYESIEPGQTFTADSSQMECNKGKNRYPNIHAYDHSRVRLSYINGIEGSDYINANFCDG
    | .|.  .  | .  .| . .  || |||| || ||||||| |  ..|.  |||||| . .|
rsrafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasying
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1469-1574 2.3e-10 34.3 In-house 215-342 (349) alignment 
Range on Protein: 1469-1574
Range on HMM: 215-342/349.0
SQPREVKHFQFTGWPDHGVPAHPTPFLAFLRrV-----------KFYNPPDAGPIVVHCSAGVGRTGCFIVIDSMLE--RLRHEETV----------DIY
..| |.  .|.  |.| ..   |  .|  |  |           ....  .  ...|||||| |||| .. .|..|.     ..| .           |.
ekPyellqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlis

GHVTVLRTQRNYMVQTQEQYIFSHDAILE
  |  || ||  |||   |.|. ..|.|.
iivnelrkqrismvqnlaqfiaiyealLk
Ig_3 Immunoglobulin domain 115-177 3.9e-10 31.8 Pfam-A 9-75 (75) alignment 
Range on Protein: 115-177
Range on HMM: 9-75/75.0
SGDD-----VTFTCAAVGTP-TPNITWFkdRLPIVLNDPRVSVLSDGRKLRITDLRESDNGKYSCVARN
|..      ||.|| |.|.| .|.|.|   . .   .... .  | . .| |..  ..|.| |.|||.|
sptvtsggnvtLtCsaeggpppptisWy..ietppelqgsegssssestLtissvtsedsGtYtCvasN
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1668-1724 7e-10 32.8 In-house 230-284 (440) alignment 
Range on Protein: 1668-1724
Range on HMM: 230-284/440.0
DGYRQRGLFIATQGPLQDTVDDFWRMLMEQNSNIIVMLTQLHEgewEKCYKYWPTD-R
.|| ..  ||||| ||. || ||||.. . .   |.|| || .     |  ||| . |
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvntr
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1631-1710 1.6e-09 31.7 In-house 34-112 (332) alignment 
Range on Protein: 1631-1710
Range on HMM: 34-112/332.0
NRPKNRLANILPYETTRVHISPVRGVEgsDYINASFIDGYRQRGLFIATQGPLQDTVD-DFWRMLMEQNSNIIVMLTQLHE
|   ||.  .  .. .|| ..|  | .  |. |||..||| ..  .| .| |..|  .  ||||. |.. ..|... .. |
nmdmnriphlycfdhsrvelapqdgkd..dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdide
subfamily_PTPDC1_pd Subfamily PTPDC1 1764-1859 1.8e-09 32.3 In-house 84-169 (182) alignment 
Range on Protein: 1764-1859
Range on HMM: 84-169/182.0
QFHFLGWPETGVPkSGEGIIDLIGQVQRAYEqqeeEGPITVHCSDGVGRTGVFTALFIVLER-MRSEgvvdlfQTVKLLRTQRPAMVQSQEQYLFCY
 .. .||.. ||. | | |.|..  |. | .    || ..|||  | |||||  | ..|  . . .|      ...||.| .||  .|..||  .. 
yvynfgwkDygva.sleriLdivkvvafalq....egkvavhChaGlGrtGvliacylvyakrltae......kaiklvrskrpksiqtreqvelvk
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1788-1866 2.2e-09 31.1 In-house 254-344 (349) alignment 
Range on Protein: 1788-1866
Range on HMM: 254-344/349.0
QVQRAYEQQEEEGPITVHCSDGVGRTGVFTALFIVLE--RMRSEGVVD----------LFQTVKLLRTQRPAMVQSQEQYLFCYKTALEYL
.  | | ....  .. |||| | |||||.  | ..|.   . ..  .           .. .|  || || .|||   |. ..|.. |.|.
lfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf
Ig_2 Immunoglobulin domain 207-281 3.5e-09 28.6 Pfam-A 2-79 (80) alignment 
Range on Protein: 207-281
Range on HMM: 2-79/80.0
FTLRPQDKTVDPDTDVELKCSARGSPTPSIVWEVDGSRISGQNGELIIR--GIQRSGNYSCIAdSN--MGRVQAYAYVT
..|.... .|.  ..| | |.|.| |||.. |. ||. .| .  .|.|.      ||.|.| | ||   . .  .  ||
pvlsapptvvtegenvtLtCqapgnptpkvqwykdgeelsqsqnalfipnvsaedsGtYtCra.snsegskqsnsvevt
0038934 (Phosphotyrosine protein) phosphatases II 1764-1859 4e-09 31.9 In-house 81-170 (194) alignment 
Range on Protein: 1764-1859
Range on HMM: 81-170/194.0
QFHFLGWPETGVPKSGEGIIDLIGQVQRAYEQqEEEGPITVHCSDGVGRTGVFTALFIVLERMRsegvvDLFQTVKLLRTQRPAMVQSQEQYLFCY
... | .|. |.. | | . . .  |.. ...  ..| . |||  |.||||.. | ...  .       .. . ..|.|  || ....|...   .
eylklpfpddgtvPsleillrfldlvdeflne.dpggvvaVHCkaGlgRtGtlvaaYLiyrlgm.....saeeAialfrekRpgaipnqdyleall
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1624-1674 8.5e-09 29.2 In-house 40-90 (440) alignment 
Range on Protein: 1624-1674
Range on HMM: 40-90/440.0
GAATLAINRPKNRLANILPYETTRVHISPVRGVEGSDYINASFIDGYRQRG
  |.|  |. |||  ||| |. .|| .  |.||  |||||||.|.|   | 
diaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingiesrt
ig Immunoglobulin domain 116-175 2.2e-08 25.3 Pfam-A 1-64 (64) alignment 
Range on Protein: 116-175
Range on HMM: 1-64/64.0
GDDVTFTCAA-VGTPTPNITWFKDRLPIVLNDPRVSVLSDGRK---LRITDLRESDNGKYSCVA
|..||.|| .  |.| ....|.|.  . .....  .|   ..    | |... ..|.| | ||.
GssvtLtCsvssgppstdvsWykegkgleesqktgvvenrvsaqevLtinnvtkedsGtYtCvv
Ig_3 Immunoglobulin domain 207-268 3.1e-08 25.7 Pfam-A 4-74 (75) alignment 
Range on Protein: 207-268
Range on HMM: 4-74/75.0
FTLRPQDKTVDPDTdVELKCSARGSP-TPSIVWE-------VDGSRISGQNGELIIR--GIQRSGNYSCIAD
 .. |.  ..   . |.| |||.|.| .|.| |            . |. .. | |.    . ||.|.|.| 
isvspsptvtsggn.vtLtCsaeggpppptisWyietppelqgsegssssestLtissvtsedsGtYtCvas
subfamily_ptpA1_pd Subfamily ptpA1 1822-1864 3.6e-08 27.5 In-house 354-396 (418) alignment 
Range on Protein: 1822-1864
Range on HMM: 354-396/418.0
VLERMRSEGVVDLFQTVKLLRTQRPAMVQSQEQYLFCYKTALE
....  |   ..||  |  || ||| |||  ||||||||| |.
imdkynsridfnlfsivlklreqrpgmvqqleqylfcyktild
0038934 (Phosphotyrosine protein) phosphatases II 1481-1529 5.8e-08 28.1 In-house 86-135 (194) alignment 
Range on Protein: 1481-1529
Range on HMM: 86-135/194.0
GWPDHGVPAHPTPFLAFLRRVKFYNPPD-AGPIVVHCSAGVGRTGCFIVI
 .||.|..      | ||. |....  |  | ..||| ||.||||.... 
pfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1616-1670 8.9e-08 26.0 In-house 24-77 (244) alignment 
Range on Protein: 1616-1670
Range on HMM: 24-77/244.0
SQAKKHKYGAATLAINRPKNRLANILPYETTRVHISPVRgVEGSDYINASFIDGY
 ....     | |. |  |||  ||||.. ||| .|  .  ||||||||..|.| 
dhtreflqtnavlsanatknryinilpfdetrvilsssk.kegsdyinanyiqgs
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1338-1423 1.4e-07 24.6 In-house 22-80 (169) alignment 
Range on Protein: 1338-1423
Range on HMM: 22-80/169.0
SQMECNKGKNRYPNIHAYDHSRVRLSYINGIEGSDYINAnfcdgyrkerayiatqgpmqhtaadfwRMVWEQRTFTIVMLTREEER
... ||. |||     |  | ||.|  .    |||||||                           ||.||  .  ||.|   ...
aeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddk
I-set Immunoglobulin I-set domain 18-80 1.7e-07 22.9 Pfam-A 18-80 (90) alignment 
Range on Protein: 18-80
Range on HMM: 18-80/90.0
VYMICNVTGSPMPTLTWYKNGSVIRN-SRIQIFTMPYGGLIRIGPLRAKiHKATYECEADNGVG
| . |.|.|.| |. .|.|.|| ... .|...        ..|   ...  . .|.|.| | .|
velectveGepepsvsWakdgselkssqrvkvtveeaeytLtIsnvevs.DeGkYtckatnsag
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1338-1423 2e-07 24.0 In-house 21-79 (169) alignment 
Range on Protein: 1338-1423
Range on HMM: 21-79/169.0
SQMECNKGKNRYPNIHAYDHSRVRLSYINGIEGSDYINAnfcdgyrkerayiatqgpmqhtaadfwRMVWEQRTFTIVMLTREEER
... ||. |||     |  | ||.|  .    |||||||                           ||.||  .  ||.|   ...
aeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddk
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1632-1703 2.5e-07 24.5 In-house 38-114 (347) alignment 
Range on Protein: 1632-1703
Range on HMM: 38-114/347.0
RPKNRLANILPYETTRVHISPVRGVE-----GSDYINASFIDGYRQRGLFIATQGPLQDTVDDFWRMLMEQNSNIIV
  |||  .    ..||| .|| .           ||||| |     .  .| || || ||| |||.|..  .   .|
lsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvv
subfamily_eak_pd Subfamily eak 1497-1581 2.8e-07 24.2 In-house 226-310 (332) alignment 
Range on Protein: 1497-1581
Range on HMM: 226-310/332.0
FLRRVkFYNPPDAGPIVvHCSAGVGRTGCFIVIDSMLERL--RHEETVDIYGHVTVLRTQRNYMVQTQEQYIFSHDAILEAVSCGNT
.|..  .. ||   ||.  .. |  |.| |.||| ... .  . ...  .   .   ...|.. | .. |. | ....|. .   | 
tlkky.ihtppsfapii.qsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnn
subfamily_PTPDC1_pd Subfamily PTPDC1 1472-1567 3.9e-07 24.7 In-house 81-167 (182) alignment 
Range on Protein: 1472-1567
Range on HMM: 81-167/182.0
REVKHFQFtGWPDHGVPAHpTPFLAFLRRVKFYNppDAGPIVVHCSAGVGRTGCFIVIDSMlerlrHEETVDIYGHVTVLRTQRNYMVQTQEQYIF
... ...| ||.|.||..  .  |   . |.|    . | . ||| || ||||  |    .     . . ..    ....| .|   .||.||  .
qgiyvynf.gwkDygvasl.eriLdivkvvafal..qegkvavhChaGlGrtGvliacylv.....yakrltaekaiklvrskrpksiqtreqvel
Ig_2 Immunoglobulin domain 18-90 6.2e-07 21.4 Pfam-A 17-79 (80) alignment 
Range on Protein: 18-90
Range on HMM: 17-79/80.0
VYMICNVTGSPMPTLTWYKNGSVIRNSRIQIFTmpygglirigPLRAKIHKATYECEADNGVGPPLRDSSTLI
| . | ..| | |...|||.|. . .|. ..|.          |.    .. ||.|.| |. |   ..| .. 
vtLtCqapgnptpkvqwykdgeelsqsqnalfi..........pnvsaedsGtYtCrasnsegskqsnsvevt
V-set Immunoglobulin V-set domain 114-184 9.3e-07 19.7 Pfam-A 14-107 (114) alignment 
Range on Protein: 114-184
Range on HMM: 14-107/114.0
RSGDDVTFTCAAV-GTPTPNITWFKDRL-----PIV-------------LNDPRVSVLSDGR----KLRITDLRESDNGKYSCVARNALGMVFS
  |..||..|     . . .|.|.|...      |.               . ||.. |.|.     |.|..|| .|.| |.| . .  ..|| 
aeGgsvtLpCfysssensqsiyWykqktgskpeliiryvaetnnskvgesfsgrvtlssngsksdfsLtiqnlrleDsGtYtCavsdsnedvfg
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1317-1416 1.4e-06 22.0 In-house 14-115 (347) alignment 
Range on Protein: 1317-1416
Range on HMM: 14-115/347.0
NSQFTQEYESIEPGQtFTadSSQMECNKGKNRYPNIHAYDHSRVRLSYINGIEG-----SDYINANFCDGYRKERAYIATQGPMQHTAADFWRMVWEQRT
.. | ..  .  | . ||  |.. | .  |||  . .  | .|| ||  .   .       ||||        .. || || |. .|  |||.||   . 
styfdenlanyspsk.ft..svewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkv

FTIVM
  .| 
tqvvt
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1625-1711 1.4e-06 21.3 In-house 21-80 (169) alignment 
Range on Protein: 1625-1711
Range on HMM: 21-80/169.0
AATLAINRPKNRLANILPYETTRVHISPVRGVEGSDYINAsfidgyrqrglfiatqgplqdtvddfwRMLMEQNSNIIVMLTQLHEG
 | |..|  ||| |  |    |||..  |    |||||||                           ||. | |. .||.| .  . 
maeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddk
PTEN_1 1778-1856 1.4e-06 23.3 In-house 109-185 (196) alignment 
Range on Protein: 1778-1856
Range on HMM: 109-185/196.0
SGEGIIDLIGQVQRAYEQQEEEGPITVHCSDGVGRTGVFTALFIvlerMRSEGvVDLFQTVKLLRTQR-PAMVQ--SQEQYL
| . ..| . ..  .. ...... . |||  |.||.|.  | .     |....  .  ....|.| .| |....  |||..|
slselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayL....mykgk.ltadeAlelvrekRppgapnspsqerll
fn3 Fibronectin type III domain 988-1060 1.5e-06 21.5 Pfam-A 5-84 (85) alignment 
Range on Protein: 988-1060
Range on HMM: 5-84/85.0
DVRPRTVGSDWVILEWLPP----RIDAGIDTPLTHADEVR-VDALTADVQT--FKVQGLVPHMKYTVRLSASNAMGEGPR
... . |.|. . |.| ||    . . | .  . .... .     |.. .|  ....|| |...|..|. | |. ||||.
nlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpe
subfamily_PRL_pd Subfamily PRL 1780-1861 2.1e-06 21.8 In-house 72-147 (151) alignment 
Range on Protein: 1780-1861
Range on HMM: 72-147/151.0
EGIIDLIGQVQRAYEQQEEEgPITVHCSDGVGRTGVFTALFIVLERMRSEgvvdlfQTVKLLRTQ-RPAMVQSQEQYLFCYKT
| . . .  ........ ..  ..|||  |.||. |. || .. . |..|      ..|...|.. | |. . | ..|  ||.
evveeWlellkekfkeepks.tvavhcvaGlGraPvlvalalieaGmkye......davefirekrrgainskqlkflekyka
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1625-1710 2.2e-06 20.6 In-house 20-78 (169) alignment 
Range on Protein: 1625-1710
Range on HMM: 20-78/169.0
AATLAINRPKNRLANILPYETTRVHISPVRGVEGSDYINAsfidgyrqrglfiatqgplqdtvddfwRMLMEQNSNIIVMLTQLHE
 | |..|  ||| |  |    |||..  |    |||||||                           ||. | |. .||.| .  .
maeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtdd
P12 Virus attachment protein p12 family 1242-1271 3.1e-06 14.8 Pfam-A 2-34 (59) alignment 
Range on Protein: 1242-1271
Range on HMM: 2-34/59.0
LVIVTVIVLAVLYV--MRMRRRRRS-KKESKCK
..|. .|..||.|.   ........ .....|.
iiigliilaavayillrkiikqkkkGgcgcgCs
subfamily_CDC14_pd Subfamily CDC14 1509-1564 5.2e-06 20.5 In-house 263-322 (328) alignment 
Range on Protein: 1509-1564
Range on HMM: 263-322/328.0
AGPIVVHCSAGVGRTGCFIVIDSMLE-RLRHEETVD---IYGHVTVLRTQRNYMVQTQEQ
 | |.||| ||.||||..|    | . |. ..|..    |    .|.  |...... |..
eGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrPGsvigpqqkfleekqaa
subfamily_CDC14_pd Subfamily CDC14 1797-1857 5.5e-06 20.4 In-house 261-317 (328) alignment 
Range on Protein: 1797-1857
Range on HMM: 261-317/328.0
EEEGPITVHCSDGVGRTGVFTALFIVLERmRsegvVDLFQTVKLLRTQRPAMVQSQ-EQYLF
. || |.|||  |.|||| . | ... .  |    .   ...  ||  || .| .. ...| 
kaeGaiavhCkaGLGrtGtLiacylmkhy.r....ftaaeaiawlricrPGsvigpqqkfle
subfamily_DSP23_pd Subfamily DSP23 1779-1857 6.1e-06 21.0 In-house 67-139 (148) alignment 
Range on Protein: 1779-1857
Range on HMM: 67-139/148.0
GEGIIDLIGQVQRAYEQQEeegPITVHCSDGVGRTGVFTALFIVLERMRSEGvvdlfQTVKLLRTQRPAMVQSQEQY--LF
 | . ...  |. | |..|    ..|||  | |||| . | ..| ||  . .     ...  .| .||  |.. ||   ..
leqvvefvrvveeaeekne...avsvhcllgrgrtgtmlacylvkerklaaa.....eaiaevrrlrpgsvetveqeklvr
TMEM154 TMEM154 protein family 1233-1273 8.6e-06 17.1 Pfam-A 60-97 (146) alignment 
Range on Protein: 1233-1273
Range on HMM: 60-97/146.0
YVIIPVVLLLVIVTVIVLAvlyVMRMRRRRRSKKESKCKDE
 .||| |.| ... |.|.    |....|.|| ..|.. ...
miiiPsvvLillllvvvil...vikkkrkrrKqeetsedek