Gene NvecPTP-Un-2 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP081_AA protein Get Run
NvecP081_AA_7-320 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 2-360 1.7e-144 477.5 In-house 2-319 (564) alignment
Range on Protein: 2-360
Range on HMM: 2-319/564.0
HEPIPYEAFRSHVKHLHADCDYKFFMEFEGVHEKnKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPL
..|||......||..|.|..|.||..|.. ..|. .. || ...||.|..|||.||.||||||||||| .|.|..|.||||...|.|....|||||||||
skpipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPl

AKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKnRkTENHGPLTITFVQEETFAYYSIRTFEIKPNKdgthytqymhgtmfdssastnmllde
|.||.|||||.||||...|||.|.. |||..||..|||.| . ||..| ||.|...||..|.|.||||..| .|                          
aetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkk..........................

sldplddEVKPMMVKQFHFTGWPDHGAPEPGfeFPVLDLIMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHL
       . . ..|.||||| |||||.|| .   ..||||.|..|.  |..||.||||||||||.|.|||||.|..||......||.......|.|||..
.......ssesreVrqFhFtsWPdhgvpesa..tslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnam

VQEECQYIFIHDTLAEYIACnFVISLPIKALKDHVRMMRMPISIQppVKSKLDLEYEVL
||.|.||||||....|..|| .. ......||.|.....   . .    ..|.||.. |
VqteeQYiFiheailealac.gntevesenlkqhlqkLaeveedt..emtgleleFqrL

subfamily_PTPRG_pd Subfamily PTPRG 5-321 2.8e-98 324.6 In-house 1-289 (563) alignment
Range on Protein: 5-321
Range on HMM: 1-289/563.0
IPYEAFRSHVKHLHADCDYKFFMEFEGVHE--KNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTEN-DQSSHYINANYVDTYNAMNAYIATQGPL
.| . | .|| .|||| | .|  ||| ...  ..| |.  .||||||. |||  |.||||.||| || . . ...  ||||||.| |.  .|.|||||||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

AKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTknRKTENHGPLTITFVQEETFAYYSIRtfeikpnkdgthytqymhgtmfdssasTNMLLDE
..|. ||||||||||  .||||||. |.||.|| .|||.   ..|. | |..| ..||..|.|..|                           | .. . 
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvr...........................tlviknl

SLDPLDDEVKPMMVKQFHFTGWPDHGAPEpgFEFPVLDLIMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHL
 |.  ..  .  .|.|.|.| |||||.||  .. |||  . || |     .||.||||||||||.| .||.|...|.|...   ..|.|| ||| |||.|
klkkkkqcdteklvrqyhytkWPdhgvPe..hslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnfl

VQEECQYIFIHDTLAEYIAC
||.| ||||.||.| | || 
vqteEqYiflhdalleaias

0051299 (Phosphotyrosine protein) phosphatases II 2-319 4.7e-95 313.6 In-house 2-286 (288) alignment
Range on Protein: 2-319
Range on HMM: 2-286/288.0
HEPIPYEAFRSHVKHLHADCDYKFFMEFEGVHEKNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPL
. .|..| ....|..|.|.. .....||| . ...  ||.  ...|||. |||. ....||||||.|| .... .| ||||.|.|.||  ...|||||||
dteisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPl

AKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTknRKTENHGPLTITFVQEETFAYYSIRTFEIKPNKDGThytqymhgtmfdssastnmllde
 .|..|||||.||||.|||||.|...|.|| ||| |||.  ......|..|.|.. ||....| .||.|.....  .                       
pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlld.......................

sldpldDEVKPMMVKQFHFTGWPDHGAPEpgFEFPVLDLIMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHL
       . .. .|..||.|.|||||.|.     ..||....   .  .| || ||||||||||.|.||..| .. ... .| .|........|.||...
......gdgesrtvthfhytnwpdhgvpd..spellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgm

VQEECQYIFIHDTLAEYI
|| ..||.|....|.||.
vqtpeqyrfvyealleyl

0050432 (Phosphotyrosine protein) phosphatases II 2-322 2.7e-93 307.9 In-house 23-302 (308) alignment
Range on Protein: 2-322
Range on HMM: 23-302/308.0
HEPIPYEAFRSHVKHlhADCDYKFFMEFEGVHEKNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLsltenDQSSHYINANYVDTY--NAMNAYIATQG
....... .  ....  |.. .....||| . ..   |..  ...|||. |||. ....||||||.|     |..|.||||.|||.|  .  ...|||||
slklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqg

PLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNR-KTENHGPLTITFVQEETFAYYSIRTFEIKPNKdgthytqymhgtmfdssastnml
|| .|. |||||.||||.|||||.|...|.|| ||| |||..   .....|..|.|.. ||....| .||.|.....                       
PlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlg.......................

ldesldplddEVKPMMVKQFHFTGWPDHGAPEPgfEFPVLDLIMKSTACVvpGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQR
          . .  .|..||.|.|||||.|.     ..||.. .   .   . || ||||||||||.|.||..| .. ... .| .|.|. ....| ||
..........dgesrtvthfhytnWpdhgvPps..peilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqR

NHLVQEECQYIFIHDTLAEYIACN
.. || . ||.|....|.||. . 
pgmvqtpeqylflyralleylklk

0040438 (Phosphotyrosine protein) phosphatases II 8-337 1.3e-89 295.9 In-house 3-293 (317) alignment
Range on Protein: 8-337
Range on HMM: 3-293/317.0
EAFRSHVKHLHADCDYKFFMEFEGVHEKNKRlTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAKTISD
. .  ... |..   ...  ||| . . ..  |.  ...|||. |||. ... ||||||.|| ...| .| ||||.|||..|  ...||||||| .|. |
ldlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntved

FWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTknRKTENHGPLTITFVQEETFAYYSIRTFEIKPNKDgthytqymhgtmfdssastnmlldesldpld
||||.|||...||||.|.  |.|| ||| |||.  ..| ..|..|.|...||. |.. .||.|.....|                               
FwrmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgd...............................

deVKPMMVKQFHFTGWPDHGAP-EPGFEFPVLDLIMKSTAcvvPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEEC
   .. .|..||.|||||||.|  |   .  |... .. .   .. ||..|||||||||.|.||... |. ... .|..|... ....|.||.. || . 
..sesrtvthfhytgWpdhgvppspdllldfleavreale...dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpe

QYIFIHDTLAEYIACNFViSLPIKALKDHVR
||.|..| |.||. .. . . |.. || .. 
qyrflydalleylkrklt.lepaselklkll

0036941 (Phosphotyrosine protein) phosphatases II 17-330 1.1e-88 292.7 In-house 7-288 (297) alignment
Range on Protein: 17-330
Range on HMM: 7-288/297.0
LHADCDYKFFMEFEGVHEKNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLslteNDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQN
 .... ...  ||| . .  .  ..  ...|||. |||. ....|||.||.|    .|..| ||||.|||.|.  ...||||||| .|. |||||.||||
ekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqn

CRVIVMITNIIEKGRHKCAMYWPTKNRKTENHGPLTITFVQEET--FAYYSIRTFEIKPNKDgthytqymhgtmfdssastnmlldesldplddeVKPMM
..||||.|. .|.|| ||| |||...... ..|..|.|.. .|.  ...| .||.|......                                  .. .
vtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgn.................................gesrt

VKQFHFTGWPDHGAPE-PGFEFPVLDLIMKSTaCVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIH---DNGDLDIFNFLAHIRNQRNHLVQEECQYIF
|..||.|||||||.|| |   .  ..|. |      |. || .|||||||||||.||..| |. ...    .| .||.... ..|.||.. || . ||.|
vthfhytgwpdhgvpespaslldfielvrkvl.kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrf

IHDTLAEYIACNFVISLPIK
....|.|.. .. ..  ..|
lyeallellkkkltkepllk

0046845 (Phosphotyrosine protein) phosphatases II 25-323 9.5e-88 289.5 In-house 2-278 (284) alignment
Range on Protein: 25-323
Range on HMM: 2-278/284.0
FFMEFEGVHEKNKRL--TWVQSQKPENQMKNRFANVVAYDHSRVVLSLTEND-QSSHYINANYVDTY-----NAMNAYIATQGPLAKTISDFWRMIWEQN
.. ||| .   .  |  ..  ...|||. |||. ....||||||.|. ...| ..|.||||.|||.|     .  ...||||||| .|. |||||.||||
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

CRVIVMITNIIEKGRHKCAMYWPTKnRKTENHGPLTITFVQEETFAYYSIRTFEIKPNKDgthytqymhgtmfdssastnmlldesldplddEVKPMMVK
.|||||.|...|.|| ||| |||..  .. ..|..|.|.. ||.. .| .||.|.....                                 . ....|.
vrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgy................................tgesrtvt

QFHFTGWPDHGAPEP-GFEFPVLDLIMKSTACvVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNG---DLDIFNFLAHIRNQRNHLVQEECQYIFIH
.||.|.|||||.|.     .  |.|. ..    .|| || ||||||||||.|.||..| ...... .|    .|... ....|.||.. || . ||.|..
hfhytswpdhgvppspedlleflrlvrellen.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvy

DTLAEYIACNF
..|.||. . .
ealleylklkl

0047943 (Phosphotyrosine protein) phosphatases II 18-319 5.4e-87 287.0 In-house 7-272 (273) alignment
Range on Protein: 18-319
Range on HMM: 7-272/273.0
HADCDYKFFMEFEGVHEKNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLslteNDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNC
.... .....||| . .  . ||.  ...|||. |||. ....||||||.|    .|..|.||||.|||.||  ...||||||| .|. |||||.||||.
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv

RVIVMITNIIEKGRHKCAMYWPTKNRK-TENHGPLTITFVQEETFAYYSIRTFEIKPNKdgthytqymhgtmfdssastnmlldesldplDDEvkPMMVK
|||||.|...|.|| ||| |||... . ....|..|.|.. |||...| .||.|.....                               ..|  . .|.
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlg...............................tge..srtvt

QFHFTGWPDHGAPEPGFEFPVLDLIMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHDTLA
.||.|||||||.|.   ..  .  .....   .|. || ||||||||||.|.||..| .. ... .| .|... ....|.|| . || ..||.|....|.
hfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyeall

EYI
||.
eyl

0043336 (Phosphotyrosine protein) phosphatases II 4-319 6.4e-87 286.8 In-house 1-277 (278) alignment
Range on Protein: 4-319
Range on HMM: 1-277/278.0
PIPYEAFRSHVKHLHADCDYKFFMEFEGVHEKNKrLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAK
||... .  ....|.... ...  ||| ... ..  |.  ...|||. |||. ....||||||.|||...| .| ||||.|||.||  ...||||||| .
pisvkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe

TISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPtknRKTENHGPLTITFVQEETFAYYSIRTFEIKPNKDGthytqymhgtmfdssastnmlldesl
|. |||||.||.....|||.|.  |.|| ||| |||   ......|..|.|.. ||....| .||.|.....||                          
tvedFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdg..........................

dplddevKPMMVKQFHFTGWPDHGAP-EPGFEFPVLDLIMKSTAcvvPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLV
       .. .| ..|..||||||.|  .   .  |  ...  .   .  ||..|||||||||.|.||... .. .....| .|... ....|.|| . |
.......esrtvthyhylgwpdhgvpeslsllldflkavreale...dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgav

QEECQYIFIHDTLAEYI
| . ||.|... |.||.
qtpsqyrflyealleyl

subfamily_PTPRD_pd Subfamily PTPRD 392-612 3.4e-86 285.1 In-house 52-261 (564) alignment
Range on Protein: 392-612
Range on HMM: 52-261/564.0
RRVPRICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHdTAHFGDYEV
.|.  |.  |.|||.| . .|.|||||||||.|||...|.|.||||.||..|..|.|||.|..|...|||| . .|..|. . .| |. . |...|...|
NRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg.tetygeltV

TMESETARGDFIIRDLKLiSTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESeveknshqfDIIGPIVVHCNNGIGRTGVYCALHALWQQ
|.|.|.   |..||..|| ..|. |  |..|.||| .||.||.|.|....|.|..||.....         .  |||||||..|.||||......|....
tleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne.........pdagPivVhCSaGVGRTGtfividamler

ITQEKLVSVYQTAWLQGHQRP
|..||.| .||. ..  .||.
ikeektvDiyqyvkalrkqRn

0045450 (Phosphotyrosine protein) phosphatases II 2-320 1.5e-85 282.9 In-house 6-305 (307) alignment
Range on Protein: 2-320
Range on HMM: 6-305/307.0
HEPIPYEAFRSHVKHLHADCDYKFFMEFEGVHEKNK--RLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTEND-QSSHYINANYV--------DTYNA
...|... . ..|. |..|. .... ||| . . ..    ..  ...|||. |||. ....|||.||.|| .... ..|.||||.||        |.|. 
slfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydl

MNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKnRKTENHGPLTITFVQEETFAYYSIRTFEIKPN-KDGthytqymhgtmf
 ...||||||| .|. |||||.|||...||||.|. .|.|| |||.|||.. . . ..|..|.|.. ||. ..| .||.|.... ..|            
krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtg............

dssastnmlldesldplddevKPMMVKQFHFTGWPDHGAPE-PGFEFPVLDLIMKSTACVvPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGD---L
                     .. .|..||.|||||||.|. .   .  .....|  .   |. || .|||||||||.|.||... |.......|    .
.....................esrtvthfhytgwpdhgvppsfeelldfieevrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldv

DIFNFLAHIRNQRNHLVQEECQYIFIHDTLAEYIA
|... ....|.|| . || . ||.|... |.|.. 
dlleavkllreqRpgavqnpeqyrflyeallelll

DSPc_SM00195 25-319 6.1e-85 280.1 In-house 2-262 (263) alignment
Range on Protein: 25-319
Range on HMM: 2-262/263.0
FFMEFEGVHEKNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMIT
. .||| . |...  .  ...|..|. |||. |.. |||.|| |. .|....| ||||||....|  ..|||||||| .|..|||||.||.....|||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NIIEKGRHKCAMYWPTKNRKTENHGPLTITFVQEETFA-YYSIRTFEIKPNKDgthytqymhgtmfdssastnmlldesldplddeVKPMMVKQFHFTGW
.  |.|. ||. ||| .. ..|..| .....|..|.    . .||.|.. ...                                  ..  |.|.....|
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.................................eetrkvtqyqyknW

PDHGAPEPgfEFPVLDLIMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHDTLAEYI
||||.|.   . .||.|. . . .    .||.||||||||||.|.|..||......... ..|||. . ..|.|| ..||.. ||.||.....|||
pdhgvpds..tksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 25-319 6.1e-85 280.1 In-house 2-262 (263) alignment
Range on Protein: 25-319
Range on HMM: 2-262/263.0
FFMEFEGVHEKNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMIT
. .||| . |...  .  ...|..|. |||. |.. |||.|| |. .|....| ||||||....|  ..|||||||| .|..|||||.||.....|||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NIIEKGRHKCAMYWPTKNRKTENHGPLTITFVQEETFA-YYSIRTFEIKPNKDgthytqymhgtmfdssastnmlldesldplddeVKPMMVKQFHFTGW
.  |.|. ||. ||| .. ..|..| .....|..|.    . .||.|.. ...                                  ..  |.|.....|
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.................................eetrkvtqyqyknW

PDHGAPEPgfEFPVLDLIMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHDTLAEYI
||||.|.   . .||.|. . . .    .||.||||||||||.|.|..||......... ..|||. . ..|.|| ..||.. ||.||.....|||
pdhgvpds..tksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_Ptp69D_pd Subfamily Ptp69D 5-322 2.7e-82 271.3 In-house 4-289 (307) alignment
Range on Protein: 5-322
Range on HMM: 4-289/307.0
IPYEAFRSHVKHLHADCDYKFFMEFEGVHEKNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAKT
|. .  .. .|  . | |. .  |.| .....  .. . |.| ||..|||. ...|.|. ||.|. .. ...| ||||... .|.  . .|| |.|.  |
iaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveat

ISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKnrKTENHGPLTITFVQEETFAYYSIRTFEIKPNKDGTHYTqymhgtmfdssastnmlldesld
| ||||||.||.  .|||..|. || |.||| |||    .. ..| . ...|.||.  .| ||....  .|. .                          
igDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgev.......................

plddeVKPMMVKQFHFTGWPDHGAPEPGfeFPVLDLIMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQE
      .   | |.|.|||.|  .||      .|.|| .         .|.|||||||||||| |. .||...... .  .|||..  ..|.||| ||| 
.....edsrkvvqyhytgWkDskvPeva..rgllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqs

ECQYIFIHDTLAEYIACN
  ||.|..  |..|.   
leqYvflyralldyssyg

0039614 (Phosphotyrosine protein) phosphatases II 2-321 2.9e-82 271.8 In-house 11-291 (297) alignment
Range on Protein: 2-321
Range on HMM: 11-291/297.0
HEPIPYEAFRSHVKHLHADCDYKFFMEFEGVHEKNKRltWVQSQKPENQMKNRFANVVAYDHSRVVLSLTEN-DQSSHYINANYVDTYNA-MNAYIATQG
..|||....  ......|.. .....||| . . .    .. ...|||. |||. ....||||||.|.  .. | .| ||||.|||.|.   ...|||||
sipiplsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqg

PLAKTISDFWRMIWEQNCRVIVMITNIIEKGRhKCAMYWPTKNRkteNHGPLTITFVQEETFAYYSIRTFEIkpnkdgthytqymhgtmfdssastnmll
|| .|. |||||.|||...||||.|. .|.|| ||| |||..     ..|..|.|....|. ..| .||.|.                            
PlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlev............................

dE------SldplddevkpmmVKQFHFTGWPDHGAPE-PGFEFPVLDLIMKSTACVvPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLA
 .                   |..|..|||||||.|. .   . .|.|...  |   |. || .|||||||||.|.||... |. ... .|..|... ..
.tnngesrt............vthfqytgwpdhgvppslellleflelvrealael.pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavk

HIRNQRNHLVQEECQYIFIHDTLAEYIAC
..|.||.. || . ||.|..| |.|.. .
elreqRpgavqtpsqyrflydallellkr

subfamily_PTPRK_pd Subfamily PTPRK 12-333 1.5e-80 265.4 In-house 11-290 (314) alignment
Range on Protein: 12-333
Range on HMM: 11-290/314.0
SHVKHLHADCDYKFFMEFEGVHEKnkrltWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRM
 ... |..   | |  |.| . |      |  ..| ||..|||. ...|||.|||.|  ...|.|| ||||...|.|.  .|.|.||||| .|. ||||.
qsiallkraegygfkeeyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrl

IWEQNCRVIVMITNIIEKGRHKCAMYWPTKnrkTENHGPLTITFVQEETFAYYSIRTFEIKPnkdgthytqymhgtmfdssastnmlldesLDPLDDEVk
....||  |||.|...|.|| ||  ||| .   || .|.. ...|. |. | . .|.| ..                              |    .|. 
vydencasivmltelvevgrvkClkyWPed...tevygdikvelvetellaelvvrifrvek.............................largqeei.

pMMVKQFHFTGWPDHGAPEpgFEFPVLDLIMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFI
  .|.||.|.|||||. |    .  .|.|. .  .   .. |..||||||| ||.|.||.||...  |. .| .|.||    .|...  .|. | ||.||
.revrqfqflgWpdhdvPv..satgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfi

HDTLAEYIACNFvISLPIKALK
.| . |   |    ..|.  .|
ydvileaclcge.taipvsefk

subfamily_PTPN6_pd Subfamily PTPN6 24-320 8.1e-79 259.8 In-house 27-298 (306) alignment
Range on Protein: 24-320
Range on HMM: 27-298/306.0
KFFMEFEGVHE--KNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSlTENDQSSHYINANYVD--TYNAMNAYIATQGPLAKTISDFWRMIWEQNCRV
 |  ||| . .  ..|.|.  ...||||. |||. |.. .||.||.|.  .. . | ||||||..  . .  ..|||||| | .|.||||||.|..|.||
gfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrv

IVMITNIIEKGRHKCAMYWPTKNRKTEnHGPLTITFVQEETFAYYSIRTFEIKPNkdgthytqymhgtmfdssastnmlldesldplDDEVKPMMVKQFH
|||.|. .|.|..||| |||....|.| .| ...| |.|.. |.| .|.. .. .                                ... .   | |.|
ivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskk................................kkkkeerevfqyh

FTGWPDHGAPEPGFE-FPVLDLIMKSTACVV-PGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNG---DLDIFNFLAHIRNQRNHLVQEECQYIFIHDT
|. ||||| |.        |. . . .  .    .||.|||||||.|| |.||||| ..| |. .|   |.|| ..   .|.||. ||| | || |.. .
fksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvyka

LAEYIA
...|| 
ikkyie

Y_phosphatase Protein-tyrosine phosphatase 49-317 3.1e-78 257.8 Pfam-A 1-235 (235) alignment
Range on Protein: 49-317
Range on HMM: 1-235/235.0
NQMKNRFANVVAYDHSRVVLslTENDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNRKTENH
|. |||. ....||..|| |  ......| |||||||..|.  ...||||||| .||.|||||.|.....||||.|.  |||| ||| |||.........
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GPLTITFV-QEE-TFAYYSIRTFEIKPNKDGThytqymhgtmfdssastnmlldesldplddevKPMMVKQFHFTGWPDHGAPEPgfEFPVLDLIMKSTA
| .... . .|.   . | .|..|.| .|. .                                .. .|||.|.|.|||||.||     ..|||| |   
gdikvelkekekedekeytlrklelkkkkees................................ekrevkqlhytnWpdhgvpes..pkslldlirkvek

CVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHDTLAE
   . .||.||||||||||.| |...| ...........|..... ..|.||...||.. ||||......|
skeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

Y_phosphatase Protein-tyrosine phosphatase 49-317 3.1e-78 257.8 In-house 1-235 (235) alignment
Range on Protein: 49-317
Range on HMM: 1-235/235.0
NQMKNRFANVVAYDHSRVVLslTENDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNRKTENH
|. |||. ....||..|| |  ......| |||||||..|.  ...||||||| .||.|||||.|.....||||.|.  |||| ||| |||.........
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GPLTITFV-QEE-TFAYYSIRTFEIKPNKDGThytqymhgtmfdssastnmlldesldplddevKPMMVKQFHFTGWPDHGAPEPgfEFPVLDLIMKSTA
| .... . .|.   . | .|..|.| .|. .                                .. .|||.|.|.|||||.||     ..|||| |   
gdikvelkekekedekeytlrklelkkkkees................................ekrevkqlhytnWpdhgvpes..pkslldlirkvek

CVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHDTLAE
   . .||.||||||||||.| |...| ...........|..... ..|.||...||.. ||||......|
skeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

0045098 (Phosphotyrosine protein) phosphatases II 22-321 1e-76 253.2 In-house 6-274 (278) alignment
Range on Protein: 22-321
Range on HMM: 6-274/278.0
DYKFFMEFEGVHEKNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVlsltendqssHYINANYVDTYNamNAYIATQGPLAKTISDFWRMIWEQNCRVIV
......||| ..  .   ..  .....|. |||. ....||||||.           ||||.|.|.|.  ...||||||| .|..|||||.||....|||
sldlllefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgyp..kkfIatqgPlpstvadfwrmlwelgitviv

MITNIIEKGRHKCAMYWPTknRKTENHGPLTITFVQEETFAYYSIRTFEIKPN----KDgthytqymhgtmfdssastnmlldesldplddeVKPMMVKQ
|.|. .|.|| |||.|||   ......|..|.|...||.. .| .||...       .|                                  ... |..
mltelvelgrekcaqywpe..ggsltygdftvtllseevlddytlrtllvtnltvered.................................lesrgvth

FHFTGWPDHGAPEPGFEFPVLDLIMKSTACVV-------------PGTGPLVVHCSAGVGRSGAFIVIDSMIKRIhdNGDLDIFNFLAHIRNQRNH-LVQ
.|...|||||.|.  .  ..|.|.    ...              .. || .|||||||||.|...... |....  .| .|... ....|.||..  ||
lhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavq

EECQYIFIHDTLAEYIAC
 . ||.|... |.|.. .
nleqyrflyefllelllr

0040439 (Phosphotyrosine protein) phosphatases II 41-320 7.6e-76 250.3 In-house 3-247 (249) alignment
Range on Protein: 41-320
Range on HMM: 3-247/249.0
WVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPT
.  ...|||. |||. ....||||||.|| ...   | ||||.|.|.|.  ...||||||| .|..|||||.||....||||.|.  |.|| ||| |||.
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

knRKTENHGPLTITFVQEETFAYYSIRTFEIKPNKdgthytqymhgtmfdssastnmlldesldplddEVKPMMVKQFHFTGWPDHGAP-EPGFEFPVLD
  ... ..| .|.|....|....| .||.|.....                                 . .. .|.....|.|||||.|  .   .  ..
..ggsleygdftvtllsvevkddytvrtleltnly.................................dgesrtvlhiqytdwpdhgvppsfedlldfie

LIMKSTACVvPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHDTLAEYIA
...|  .   |  ||..|||||||||.|.||... |. ... ....|... ....|.||.. || . ||.|... |.|.. 
avrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll

0042113 (Phosphotyrosine protein) phosphatases II 45-319 2.1e-75 248.6 In-house 5-243 (245) alignment
Range on Protein: 45-319
Range on HMM: 5-243/245.0
QKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTknRK
..|||. |||. ....|||.||.|| ...|  | ||||.|||.|.  . .|||||||..|. |||||.||.....|||.|.  |.||.||| |||.  . 
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..ge

TENHGPLTITFVQEETFAYYSIRTFEIKPNKDgthytqymhgtmfdssastnmlldesldplddeVKPMMVKQFHFTGWPDHGAPE-PGFEFPVLDLIMK
. ..| .|.|.. ||....| .||.|.....|                                  .. .| ..|...|||||.|. .   . .|... |
sltygdftvtllseehlddytvrtlevtnlgd.................................desrevihyhylpwpdhgvpdllellldflefvrk

STACvvPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHDTLAEYI
  |   .. ||..|||||||||.|.||... |. ... ........ ....|.|| . || . ||.|... |.|..
alae..dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell

0037934 (Phosphotyrosine protein) phosphatases II 41-319 2.3e-70 232.2 In-house 2-242 (243) alignment
Range on Protein: 41-319
Range on HMM: 2-242/243.0
WVQSQKPENQMKNRFANVVAYDHSRVVLslteNDqsSHYINANYVDTYNamnAYIATQGPLAKTISD----FWRMIWEQNCRVIVMITNIIEKGRHKCAM
.  ...|||. |||. ....||||||.|    ..  | |||||... ..    .||||||| .|. |    ||||.||....||||.|. .|.|| |||.
fsiallpenlsknrysdilpydhsrvkl....eg..sdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPtknRKTeNHGPLTITFVQEETFAYYSIRTFEIKpnkdgthytqymhgtmfdssastnmlldesldPLDDEVKPMMVKQFHFTGWPDHGAPE-PGFEF
|||    .. ..|..|.|...||....| .||....                                .|| .  . .| ..|...|||||.|. |    
ywp...gev.tygdftvtllseehlddytvrtllle................................nldlddltrlvihyhylpwpdhgvPdspedll

PVLDLIMKSTAC-----VVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIhdngDLDIFNFLAHIRNQRNH-LVQEECQYIFIHDTLAEYI
  || . .         . .. ||..|||||||||.|..|... |....    ..|... ....|.||..  || . ||.|... |.|..
dfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallell

0046845 (Phosphotyrosine protein) phosphatases II 390-612 3.6e-69 228.6 In-house 30-254 (284) alignment
Range on Protein: 390-612
Range on HMM: 30-254/284.0
PLRRVPRICVIDSSRVRLYPRPGE-EGSDYINASYIDGF-----TRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHDT
 . | . | . |.|||.| . .|. |.||||||||.||.      .. .|||||.||..|. |.|||.|..|.| |||| .. | ..  .. | |  ...
sknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegev

AHFGDYEVTMESETARGDFIIRDLKLISTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEveknshqFDIIGPIVVHCNNGIGRTGVYC
 ..||. ||. ||. ..|...| |.|  .. ..  |...|||...||.|| | | . .|... .|.|. ..       ..  ||||||| .|.||||...
ltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen.......lpgggpivVHCsaGvgRtGtfi

ALHALWQQITQEK---LVSVYQTAWLQGHQRP
||. |..|. .|.    |.|...      |||
aldllleqlekeglllgvdvleavkrlreqRp

0051299 (Phosphotyrosine protein) phosphatases II 391-612 1.2e-68 227.0 In-house 52-266 (288) alignment
Range on Protein: 391-612
Range on HMM: 52-266/288.0
LRRVPRICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAvHDTAHFGDYE
  | . |   |.|||.| . .|.|||||||||||||. .  .|||||.||..|. |.|||.|..|.| |||| .. |...  .. | |  ...  .||. 
knRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygdit

VTMESETARGDFIIRDLKLISTK---DPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESeveknshqfDIIGPIVVHCNNGIGRTGVYCALHA
||. ||.  .|...| |..  ..    ..  |...|||...||.|| | | . .|... .| .. .         .  ||.||||..|.||||...||  
vtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.........sgggpvvVHCsaGvgRtgtfialdl

LWQQITQEKLVSVYQTAWLQGHQRP
|..|. .|. |.|...     .|||
lleqlekeggvdvleavkrlreqRp

0050432 (Phosphotyrosine protein) phosphatases II 390-612 5.9e-68 224.8 In-house 70-279 (308) alignment
Range on Protein: 390-612
Range on HMM: 70-279/308.0
PLRRVPRICVIDSSRVRLyprpgEEGSDYINASYIDGF--TRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAV--HDTAH
.. | . |   |.|||.|     .||||||||||.||.   .. .|||||.||..|. |.|||.|..|.| |||| .. | ..  .. | |    ... .
dkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsle

FGDYEVTMESETARGDFIIRDLKLISTKDPSViRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWEseveKNshqfdiiGPIVVHCNNGIGRTGVYCAL
.|.. ||. ||. ..|...| |.|  ..|. . |...|||...||.|| | | . .|... .|...     ..       |||||||..|.||||...||
ygkftvtllseevlddytvrtleltnlgdges.rtvthfhytnWpdhgvPpspeilldflelvrksl....pg.......gpivVHCsaGvGRtGtfial

HALWQQITQEKLVSVYQTAWLQGHQRP
  |..|. .|. |.|...     .|||
dllleqlekeggvdvfeavkklReqRp

0040438 (Phosphotyrosine protein) phosphatases II 389-612 2.3e-66 219.6 In-house 44-256 (317) alignment
Range on Protein: 389-612
Range on HMM: 44-256/317.0
VPLRRVPRICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAvHDTAHFGD
 ...| | |   |.|||.| | .| ..||||||||.||. .. .|||||.||..|. |.|||.|......|||| ...| ..  .  | |   .| ..||
kdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl.getltygd

YEVTMESETARGDFIIRDLKLISTkDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESevEKNshqfdiiGPIVVHCNNGIGRTGVYCALHAL
. ||. ||.  .....| |..  . . |  |...|||...||.|| | | ...|.....|.|. .  ...       ||..|||..|.||||...|.  .
ftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavreale..dpg.......gpvlVHCsaGvgRtGtfiaaylm

WQQITQEKLVSVYQTAWLQGHQRP
..|. .|. |.|...     .|||
leqlekeggvdveeavkelreqRp

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 47-321 2.2e-65 215.5 In-house 26-270 (274) alignment
Range on Protein: 47-321
Range on HMM: 26-270/274.0
PENQMKNRFANVVAYDHSRVVLSLTENDQ-SSHYINANYVDTYNA-MNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNRK
. .| |||. ...  ..|||.|.  ....  |.||||||.  |.   .||.||||||..|..||||||......||||.|.. |. ..|||.|.|...  
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

--TENHGPLTITFVQEETFAYYSIRTFEIKPNKDGTHytqymhgtmfdssastnmlldesldplddevkpmmVKQFHFTGWPDHGAPEPGfeFPVLDLIM
  .|..| . |....  .   ||.|.. .|  ..  .                                   || . .| |||| .|.     ..|||..
eiserygdveikvekiverndysvrklvlkylerers...................................vkhywytdWPdhksPdda..ntlldlvl

K---STACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHDTLAEYIAC
.   |       ..| |||||||.|| |.|| |.  ........ .|...  ...| .|  .||.. || .|| .|..|  .
eveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkr

0047943 (Phosphotyrosine protein) phosphatases II 390-612 5.1e-65 215.0 In-house 40-252 (273) alignment
Range on Protein: 390-612
Range on HMM: 40-252/273.0
PLRRVPRICVIDSSRVRLyprpGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHD--TAHFG
 . | . |   |.|||.|    |..|||||||||.||. .  .|||||.||..|. |.|||.|..|.| |||| .. | ..  .. | |   .  .  .|
dknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltyg

DYEVTMESETARGDFIIRDLKLISTKDPSvIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVEKNshqfdiiGPIVVHCNNGIGRTGVYCALHA
.. ||. ||. ..|...| |.| .....   |...|||...||.|| | | . .|... .|... ... .|       ||.||||..|.||||...||. 
kftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkalealpsn.......gpvvVHCsaGvgRtgtfialdl

LWQQITQEKLVSVYQTAWLQGHQRP
|..|.  |. |.|...  |   |||
lldqlekeggvdvleavkllrsqRp

subfamily_PTPN1_pd Subfamily PTPN1 29-312 1.4e-64 212.6 In-house 12-264 (290) alignment
Range on Protein: 29-312
Range on HMM: 12-264/290.0
FEGVHEKNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENdqssHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIE
.. .... . ..  ....|||. .||. .|  |||||..|  ..|    .||||. |.  .|   || |||||..|.. ||.|.|||... .||. ...|
yldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvve

KGRHKCAMYWPTKNRKTE---NHGPLTITFVQEETFAYYSIRTFEIKPnkdgthytqymhgtmfdssastnmlldesldplDDEVKPMMVKQFHFTGWPD
|.. ||| |||..... |   ..  |......||.  || .|..|..                                      .   . .||.| |||
keqikcaqywPqgeeekellledtklkvkliseerksyytvrllelen.................................lktqetreilhfhyttwpd

HGAPEPGFEFPVLDLIMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGD---LDIFNFLAHIRNQRNHLVQEECQYIFIH
 | ||    |  .   .... ....  || |.|||||.||||.|...|... .|....|   .|| . | ..|..|  |.|   |  | .
fgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsy

0036941 (Phosphotyrosine protein) phosphatases II 390-612 1.8e-63 210.0 In-house 41-257 (297) alignment
Range on Protein: 390-612
Range on HMM: 41-257/297.0
PLRRVPRICVIDSSRVRLyprpGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAV-HDTAHFGD
.. | . |   |..||.|    ..||||||||||.||. .  .|||||.||..|. |.|||.|..|...|||| .. |...  ...| |    ..  .||
eknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygd

YEVTMESETA--RGDFIIRDLKLISTKDPsVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVEKNshqfdiiGPIVVHCNNGIGRTGVYCALH
. ||. |..    .|...| |..  |...   |...|||...||.|| | | ...|... .|... ..  ..       ||..|||..|.||.|...|. 
ftvtllsvevvllddytlrtlevtdtgng.esrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsg.......gpvlVHCsaGvgRsgtfiaad

ALWQQIT---QEKLVSVYQTAWLQGHQRP
 ..||.     |. |.....     .|||
lmlqqledklkeggvdileavkklReqRp

0043336 (Phosphotyrosine protein) phosphatases II 389-612 1e-62 207.5 In-house 46-257 (278) alignment
Range on Protein: 389-612
Range on HMM: 46-257/278.0
VPLRRVPRICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPavHDTAHFGD
....| . |   |.|||.| . .|...||||||||.||. . ..|||||.||..|. |.|||.|......|||| ...|...  .  | |   ..  .||
kdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygd

YEVTMESETARGDFIIRDLKLISTKDPSViRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESeveK-NshqfdiiGPIVVHCNNGIGRTGVYCALHA
. ||. .|.  .|...|.|..  ..|. . |...|.|.|.||.|| | | ...|... .| |. .   . |       ||..|||..|.||||...||  
ftvtllkeehlddytvrtlevtnlgdges.rtvthyhylgwpdhgvpeslsllldflkavreale...dsn.......gpvlVHCsaGvgRTGtfialyl

LWQQITQEKLVSVYQTAWLQGHQRP
|..|.  |. |.....     .|||
lleqlekeggvdleeavkelreqRp

0039614 (Phosphotyrosine protein) phosphatases II 390-612 1e-62 207.6 In-house 58-269 (297) alignment
Range on Protein: 390-612
Range on HMM: 58-269/297.0
PLRRVPRICVIDSSRVRLYPRPGE-EGSDYINASYIDGFTR-REAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKdVFPSYLPAVHDtaHFG
...| . |   |.|||.| | .|  ..||||||||.||. .   .|||||.||..|. |.|||.|......|||| ...| ..  ...| |   .   .|
dknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tyg

DYEVTMESETARGDFIIRDLKLIStKDPSviRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVEKNshqfdiiGPIVVHCNNGIGRTGVYCALHA
|. ||. ... ......| |..   ...|  |...||....||.|| | | ...|... .|.|. .| .|.       ||..|||..|.||||...|.  
dftvtllkvehldgytvrtlevtn.nges..rtvthfqytgwpdhgvppslellleflelvrealaelpkg.......gpvlVHCsaGvgRtGtfiaayl

LWQQITQEKLVSVYQTAWLQGHQRP
...|.  |. |.|...      |||
mleqlekeggvdvleavkelreqRp

0045450 (Phosphotyrosine protein) phosphatases II 387-612 1.1e-62 207.9 In-house 54-284 (307) alignment
Range on Protein: 387-612
Range on HMM: 54-284/307.0
SGVPLRRVPRICVIDSSRVRLYPRPGE-EGSDYINASYI--------DGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYL
   ...| . |   |..||.| . .|. |.||||||||.        ||. .  .|||||.||..|  |.|||.|..... |||| ...| ..   . | 
enkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqyw

PAVHDTAHFGDYEVTMESETARGDFIIRDLKLISTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVEKNshqfdiiGPIVVHCNNGIG
|   ..  .|.. ||. ||.  .....| |..  ..  .  |...|||...||.|| | | ...|... .|... .|  |.       ||..|||. |.|
Pdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkg.......gpvlVHCsaGvg

RTGVYCALHALWQQITQEKL---VSVYQTAWLQGHQRP
|||...|.  ...|. .|.    |.....  |   |||
RtGtfiaaylmlrqlekegtlldvdlleavkllreqRp

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 396-611 1.8e-62 206.2 In-house 54-259 (318) alignment
Range on Protein: 396-611
Range on HMM: 54-259/318.0
RICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAvHDTAHFGDYEVTMES
 |   |..||.| .. ||||||||||.||||..|..|.||.| ||  |  |.|||.|. |.. ||||  |.|  |.    | |  ... ..|.  |....
nilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPs.kgsrsygklvvelke

ETARGDFIIRDLKLISTKDpSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVEKnshqfdiiGPIVVHCNNGIGRTGVYCALHALWQQITQE
|.  .|...| .|.  |.  .  ||.| .|.  ||..| | || ..|.|| .|.... . ..        |||||||  |.|||||..|. .| ..| .|
evelsdyvlrefkvtrtee.eesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksga........gpivvhCsaGvGrtGvfiavdillerikae

KLVSVYQTAWLQGHQR
.|| |.||     .||
alvDvfqtvkqlreqr

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 5-176 4.1e-62 205.1 In-house 2-171 (318) alignment
Range on Protein: 5-176
Range on HMM: 2-171/318.0
IPYEAFRSHVKHLHADCDYKFFMEFEGVHEKNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAKT
|. |...|||..|... . ... |.| .. ...  |...| .| |..|||.||..||||.|| |. .|....| ||||||.| |.. .||||.|.||..|
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

ISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKnrKTENHGPLTITFVQEETFAYYSIRTFEIKPNKD
|.|||||.||||..||||.|.. |.|..|.. ||| |  .....| |...  .| ....| .|.|... .. 
ieDfWrmvWeqnsavivmltqeeergkakvhryWPsk..gsrsygklvvelkeevelsdyvlrefkvtrtee

subfamily_CG7180_pd Subfamily CG7180 43-322 8e-60 197.0 In-house 36-293 (296) alignment
Range on Protein: 43-322
Range on HMM: 36-293/296.0
QSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRhKCAMYWPTKN
.  . ||. |||  .|| ||. ||||.  . ...|.|||| |||..   ..|| |..|  .|. .|||.......  .|..|.  .  . ..  ||| | 
gglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks

rkTENHGPLTITFVQEETFAYYSIRTFEIKPNkdgthytqymhgtmfdssastNMLLDESLDPLDDEVKpmMVKQFHFTGWPD-HGAPEPGFEFPVLDLI
   |..|.. .  |.|...|   |||| .. .                      . | |   . . |..  .||.|..| |.  .  |     .  |   
..keqygeifveiveekqyanlkirtfkltkk.....................ivalteqekqvkaetR..ivklfqlteWeledkvPlstnalielrrr

MKSTACVV---PGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHDTLAEYIACN
...    |   | .||.||..| |..|||... ||  .  .. .. .|.|...  .|..|..||..  .| .| |.| |.. ||
vrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcn

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 47-316 1.4e-59 196.2 In-house 1-236 (237) alignment
Range on Protein: 47-316
Range on HMM: 1-236/237.0
PENQMKNRFANVVAYDHSRVVLSLTENDqsSHYINANYVDTYNA-MNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNRkT
.||..|||..|.||||||||||  . ..  | ||||.|.. ..   . |||.||||  .  |||.|.|...| ||||.| .||. . ||  |||  ..  
senkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdq.p

ENHGPLTITFVQEETFAYYSIRTFEIKPNKDGThytqymhgtmfdssastnmlldesldplddEVKpmMVKQFHFTGWPDHGAPEPGFEFPVLDLIMKST
. .| ||... ..| |. |..|.. .  .                                  ||.  ...|..|| |||.| |.    .  .   .   
aaygvltvslkkkeefsdytvrslllskrltlk..............................evr..lihqyqftswpdrgvpqqtaallrfrkniinr

ACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHDTLA
.  |. .|| ..||||||||.| |.|||.|... ...  .||.|..  | ..| ...| . ||.|||.|. 
sphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtil

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 393-603 1.9e-59 196.3 In-house 61-261 (298) alignment
Range on Protein: 393-603
Range on HMM: 61-261/298.0
RVPRICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHdTAHFGDYEVT
| . |  .|||||.|    ..| |||||||.......|.||||||.||..|. |.|||...|.  .|||| . .| ||  .. | | .. ....|. .|.
RyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdeg.ketygeitvs

MESETARGDFIIRDLKLISTKDPsVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVEKNshqfdiigPIVVHCNNGIGRTGVYCALHALWQQI
. |.   .|.|.| ||. ..|     |..|..|| .||..| |   ..||.|..||. ....  ..        |..|.| .|.||.| ..|.... ...
llskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnk........pvivqCsaGvgRsGtfiaidsvlerv

TQEKLVSVYQT
 .|. | |.|.
kkeqvvDvfqv

0040439 (Phosphotyrosine protein) phosphatases II 389-612 2e-59 196.5 In-house 12-226 (249) alignment
Range on Protein: 389-612
Range on HMM: 12-226/249.0
VPLRRVPRICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAvHDTAHFGD
....| | |   |.|||.| . || ..|||||||||||. .  .|||||.||..|. |.|||.|......|||| |..| ..  .  | |   ..  .||
kdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.ggsleygd

YEVTMESETARGDFIIRDLKLISTKDPSViRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVEKNshqfdiiGPIVVHCNNGIGRTGVYCALHAL
. ||. |..  .|...| |.|  ..|... |...|.....||.|| | | ...|... .|... .| .|.       ||..|||..|.||||...|.  .
ftvtllsvevkddytvrtleltnlydges.rtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkg.......gpvlVHCsaGvgRtGtfiaaylm

WQQITQEKLVSVYQTAWLQGHQRP
..|.  |. |.....  |  .|||
leqlekelgvdleeavkllrsqRp

DSPc_SM00195 393-604 2.5e-59 196.1 In-house 31-234 (263) alignment
Range on Protein: 393-604
Range on HMM: 31-234/263.0
RVPRICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAV-HDTAHFGDYEV
|   | ..|..||.| .....||||||||.||.| ......||||.||.||  |.|||.|.|... |||| .|.| .|    .| |   ...  ||...|
RyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisv

TMESETARG-DFIIRDLKLISTKDpSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVeknshqfdiIGPIVVHCNNGIGRTGVYCALHALWQ
.. ... .  ..|.|.|.|  ... .  |.......  ||.|| | | . ||.|...|....|.           ||||||| .|.||||...... ...
klvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.........sgpivVhCsaGvgRtgtfvtidiils

QITQEKLVSVYQTA
....|| |.. .. 
kleeekkvdifeiv

PTPc_SM00194 393-604 2.5e-59 196.1 In-house 31-234 (263) alignment
Range on Protein: 393-604
Range on HMM: 31-234/263.0
RVPRICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAV-HDTAHFGDYEV
|   | ..|..||.| .....||||||||.||.| ......||||.||.||  |.|||.|.|... |||| .|.| .|    .| |   ...  ||...|
RyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisv

TMESETARG-DFIIRDLKLISTKDpSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVeknshqfdiIGPIVVHCNNGIGRTGVYCALHALWQ
.. ... .  ..|.|.|.|  ... .  |.......  ||.|| | | . ||.|...|....|.           ||||||| .|.||||...... ...
klvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.........sgpivVhCsaGvgRtgtfvtidiils

QITQEKLVSVYQTA
....|| |.. .. 
kleeekkvdifeiv

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 393-612 9.2e-59 194.1 In-house 53-263 (319) alignment
Range on Protein: 393-612
Range on HMM: 53-263/319.0
RVPRICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKdVFPSYLPAVHDTAHFGDYEVT
| . |  .| .|| | . .| |||||||||.|||. .||.||||| ||. |. |.|||.|.|..  .|||   .|  | |. . ..  ..  ..| . ||
ryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklk.vklkkywpeenfeeyGrlivt

MESETARGDFIIRDLKLiSTKDPSV-IRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVeeweseveKNSHQFDIIGPIVVHCNNGIGRTGVYCALHALWQQ
.|.|    |.|||.|||  .|   |  |.. ||....||.|. | .....|.|. ..        ..|..    ||||||| .|.|||| ...|.|  ..
leeeeeledyiirklkl.nkkssevetRevkhfqyteWpdhdvPekatslldllkri........rksrektqsgPivvhCsaGvGRtGtfivldamler

ITQEKLVSVYQTAWLQGHQRP
. .| .. |..|.     ||.
vkeegvlDvfstvsrlRtqRn

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 395-603 1.4e-58 193.0 In-house 16-213 (250) alignment
Range on Protein: 395-603
Range on HMM: 16-213/250.0
PRICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDvFPSYLPaVHDTAHFGDYEVTME
  |  .||||| | .  |.. |||||||...|.. |.||||||.|||.|. |.|||...|.  .|||| . || .|  .. |.| |  . ..||  |.. 
adiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP.vekaekyGdvtvsll

SETARGDFIIRDLKLISTKDpSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVEKnshqfdiiGPIVVHCNNGIGRTGVYCALHALWQQITQ
|.   .|...| ||| ..|  .  |..|..||. ||. | |   ..||.|..||.  . ....        .|..|.| .|.||.| ..|..|. ... .
skeefadytkrklklskakk.aderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagn........aPvivqCsaGvgrsGafiaidavlerlkk

EKLVSVYQT
|| | |.. 
ekvvdvfkv

subfamily_PTPRB_pd Subfamily PTPRB 2-188 5.8e-58 191.2 In-house 4-189 (293) alignment
Range on Protein: 2-188
Range on HMM: 4-189/293.0
HEPIPYEAFRSHVKHLHADCDYKFFMEFEGVHEKNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPL
..||  | | .|||...|| |..|  |.| ... .|  . .......|. |||. |...|||||| |. ......| ||||||.. ||... .|||||||
skpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPl

AKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNRKTeNHGPLTITFVQEETFAYYSIRTFEIKPNKDGTHYTQYMHGTM
 .|. |||||.||.....|||.|...|||. ||  |||.... . ..| ...|.|.||.   . ||...|. .|. .. .|| . . 
petvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepv.lyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsW

0042113 (Phosphotyrosine protein) phosphatases II 389-612 6.4e-58 191.4 In-house 10-223 (245) alignment
Range on Protein: 389-612
Range on HMM: 10-223/245.0
VPLRRVPRICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAvHDTAHFGD
....| . |   |..||.| | .|...||||||||.||. . . |||||.||..|. |.|||.|......|||| .| | ..  .. | |  ...  .||
kdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.gesltygd

YEVTMESETARGDFIIRDLKLISTkDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEveknS-HqfdiiGPIVVHCNNGIGRTGVYCALHA
. ||. ||.  .|...| |..  .   .  |...|.|.|.||.|| |.. ...|.... |... .|    . .     ||..|||. |.||||...|.  
ftvtllseehlddytvrtlevtnl.gddesrevihyhylpwpdhgvpdllellldflefvrkalae....dsn.....gpvlVHCsaGvgRtGtfiaayl

LWQQITQEKLVSVYQTAWLQGHQRP
...|.  |. ||....      |||
mleqlekelgvsleeavkelrsqRp

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 23-322 8.3e-58 190.4 In-house 15-296 (301) alignment
Range on Protein: 23-322
Range on HMM: 15-296/301.0
YKFFMEFEGVHEKNKRLTWVQSQKpENQMKNRFANVVAYDHSRVVLSLTEN--DQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVI
 ||  ... ..|.... . |. .. ||.. ||| |.. ||. |..|. ..|   .. .||||.|.| |.  ...||.|||. ||. ||||.||..    |
nkfeeqykelkegedksctvglse.enkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsi

VMITNIIEKGRHKCAMYWPTKNRKTENHGPLTITFVQEETFAYYSIRTFEIKPnKDGTHytqymhgtmfdssastNMLLDESLDPLDDEvKPMMVKQFHF
||.||  |. ..||  |||. . ..|. ||.|.|.|.| ..  . || . .|  .||.                 |  .  ...   |  ... | |.. 
vmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvki.qdgsn................ngyierkfkvksdk.sswdvlqlqv

TGWPDHGA-PEPGFEFPVLDLIMKSTAcvVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHDTLAEYI
| ||..|  .||     |.| ... .    .| ||.|||||..|.||| .. ..  .     .|  |.|.    .| ..   |.   ||..|.| . .|.
tdWpqdGvvreprtvLqviddvihrqq..kigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmyl

ACN
..|
qln

Y_phosphatase Protein-tyrosine phosphatase 392-604 2e-57 189.7 Pfam-A 5-209 (235) alignment
Range on Protein: 392-604
Range on HMM: 5-209/235.0
RRVPRICVIDSSRVRLyprPGEEG-SDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLP-AVHDTAHFGDY
.| . | ..|..||.|    |.|| ||||||.|..|... ..|||||.||.||  |.|||.|||....|||| |..| ..  .. | | . ... ..||.
nRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

EVTME-SET-ARGDFIIRDLKLISTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWEseveknshqFDIIGPIVVHCNNGIGRTGVYCALHA
.|... .|. .  ....|.|.| ..|..|  |.....|. .||.|| | | . .|.|. |||...          .  ||.|||| .|.||||...|| .
kvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.........eaksgpvvVhCsaGvgRtgtfvaldi

LWQQITQEKLVSVYQTA
|..|...|. |.|.|. 
lleqleaeeevdvlqiv

Y_phosphatase Protein-tyrosine phosphatase 392-604 2e-57 189.7 In-house 5-209 (235) alignment
Range on Protein: 392-604
Range on HMM: 5-209/235.0
RRVPRICVIDSSRVRLyprPGEEG-SDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLP-AVHDTAHFGDY
.| . | ..|..||.|    |.|| ||||||.|..|... ..|||||.||.||  |.|||.|||....|||| |..| ..  .. | | . ... ..||.
nRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

EVTME-SET-ARGDFIIRDLKLISTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWEseveknshqFDIIGPIVVHCNNGIGRTGVYCALHA
.|... .|. .  ....|.|.| ..|..|  |.....|. .||.|| | | . .|.|. |||...          .  ||.|||| .|.||||...|| .
kvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.........eaksgpvvVhCsaGvgRtgtfvaldi

LWQQITQEKLVSVYQTA
|..|...|. |.|.|. 
lleqleaeeevdvlqiv

subfamily_PTPRG_pd Subfamily PTPRG 396-611 1.4e-56 186.9 In-house 55-266 (563) alignment
Range on Protein: 396-611
Range on HMM: 55-266/563.0
RICVIDSSRVRLYPRPGEEGS-DYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAvHDTAHFGDYEVTME
 |  .|.|||.| | ||.... |||||.||||. . .||||||.||..|. |.|||||..|   |||.   .|  .   . | |.  .. ..|  .||..
nivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtli

SET-----ARGDFIIRDLKLISTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVeewesevekNSHQFDIIGPIVVHCNNGIGRTGVYCALHALW
.|      .   ..|..|||  .|.    ...|..|. .||.|| | .   ||. | |          .  . . .|||||||..|.||||.|..| .| 
eeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks.........saankaeaGPivvHcsaGvgrtGtyivldtll

QQITQEKLVSVYQTAWLQGHQR
.|| ||. | |....     ||
kqiqqenavnvfgflkhiraqR

0045098 (Phosphotyrosine protein) phosphatases II 386-612 8.9e-56 184.6 In-house 31-251 (278) alignment
Range on Protein: 386-612
Range on HMM: 31-251/278.0
LSGVPLRRVPRICVIDSSRVRlyprpgeegsDYINASYIDGFtrREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAvHDTAH
|..... | . |  .|.|||.          ||||||||||.  . .|||||.||.||. |.|||.|......|||| ...|...  .. | |  ...  
lgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe.ggslt

FGDYEVTMESETARGDFIIRDLKLIST---KDPSVIRQIRHFHFLHWPEHGQPWSG--QTVLQLVSKVEEWESEVEKNS---------HqfdiiGPIVVH
.||..||..||.  .|...|.|... .   .     | ..|.|.|.||.|| | .   . .|.|.  ..|. ... .           .     ||..||
ygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsg.....gpvlVH

CNNGIGRTGVYCALHALWQQItqEKLVSVYQTAWLQGHQRP
|. |.||||...|.. . ...  |. |.....      |||
CsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRp

subfamily_PTPRB_pd Subfamily PTPRB 393-603 8.9e-56 184.1 In-house 56-256 (293) alignment
Range on Protein: 393-603
Range on HMM: 56-256/293.0
RVPRICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHDTAHFGDYEVT
|  .|   | |||.| .  .|.|||||||.||.|.. .  ||||| || .|. |.|||.|..... ||||    |  |     | || ...  .|| .||
rytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvt

MESETARGDFIIRDLKLIStkdPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVEKNshqfdiiGPIVVHCNNGIGRTGVYCALHALWQQI
. .|.   |..||.||.      . .|..|..||. ||.|| | . .|.|..| .|.|. .. ...       .||||||  |.||||.. ||. | |.|
lvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektask.......rPivvhCsaGvGRtGtfialdrllqai

TQEKLVSVYQT
..| .| .. .
eeedyvdifgi

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 393-605 1.8e-55 183.5 In-house 66-264 (319) alignment
Range on Protein: 393-605
Range on HMM: 66-264/319.0
RVPRICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLsekewdKDVFPSYLPAVHDTaHFGDYEVT
|. .|   | ..|.| .  |||.|||||||...|. |.. .||.| ||. |  |.|||||. || .||.|       ||    | |   .  . . ..| 
riinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi.keerfkvk

MESETARGDFIIRDLKLISTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESeveKNSHQFdiigPIVVHCNNGIGRTGVYCALHALWQQI
..| .   ....||..|        ||.|. |||| ||..|.| ..  ...|| ||.  .|   |. |.     .|||||  |.|||||| .|..| ...
vdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhlts...kenhra....nivvhcsaGvGrtGvyivldvlldrm

TQEKLVSVYQTAW
 .|| | ||..  
keekqvdvynfvr

subfamily_PTPRK_pd Subfamily PTPRK 393-603 3.7e-55 181.9 In-house 48-248 (314) alignment
Range on Protein: 393-603
Range on HMM: 48-248/314.0
RVPRICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPavHDTAHFGDYEVT
|.  |   | |||.| .  |.  ||||||..||...| .|||.||.|||.|. |.||....||| |||||   .|  .     | |   || ..|| .|.
rsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWP..edtevygdikve

MESETARGDFIIRDLKLIS-TKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEveknshqfdIIGPIVVHCNNGIGRTGVYCALHALWQQ
. . ..  ....| ...   ..  . ||..|.|.|| ||.|. | | ...|.|| .|.... |           |.||||| .| ||||...|.. . . 
lvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.........eaGrivvhCsaGaGrtGtfiaidivldm

ITQEKLVSVYQT
| .|..| |...
ieregvvdvfna

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 392-603 4.2e-55 182.0 In-house 50-254 (305) alignment
Range on Protein: 392-603
Range on HMM: 50-254/305.0
RRVPRICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHDT-AHFGDYE
 |.  | . | .|..| ... .. ||||||||.||. |....|..| ||..|  |.||.|..|  ..||||   .| .||    | |  .    .||...
nrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefs

VTMESETARGDFIIRDLKLISTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEewesevekNSHQFDIIGPIVVHCNNGIGRTGVYCALHALWQ
|...||..  |.|.|.||.   .. .  |.. ....  ||.|| | .  ..|.|. .|.        .... |   |..|||..|.|||||..|..   .
velksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvq........kdqkkdkgvpllVhCsagvgRtGvfiavdiale

QITQEKLVSVYQT
.. .|. | |.. 
rlkkEevvdvfev

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 393-605 7e-55 181.5 In-house 30-228 (284) alignment
Range on Protein: 393-605
Range on HMM: 30-228/284.0
RVPRICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLsekewdKDVFPSYLPAVHDTaHFGDYEVT
|. .|   | ..|.| .  |||.|||||||.| |. |.. .|||| ||. |  |.|||||. || .||.|       ||    | |   .  . . ..| 
righilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi.keerfkvk

MESETARGDFIIRDLKLISTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESeveKNSHQFdiigPIVVHCNNGIGRTGVYCALHALWQQI
..| .   ....||..|        ||.|| |||| ||..|.| ..  ...|| ||.  .|   |. |.     .|||||  |.|||||| .|..| ...
vdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhlts...kenhra....nivvhcsagvgrtgvyivldvlldrm

TQEKLVSVYQTAW
 .|| | ||..  
keekqvdvynfvr

subfamily_PTPN6_pd Subfamily PTPN6 397-597 1.6e-52 173.4 In-house 63-259 (306) alignment
Range on Protein: 397-597
Range on HMM: 63-259/306.0
ICVIDSSRVRLYpRPGEEGSDYINASYIDGFT--RREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHDTAHFGDYEVTME
|   | .|| |  .|.  |||||||.||.. .   ....||||  |..|  |.|||.||||.| |||.  | |  |.    | |..... ..|...||. 
ilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnv

SETARGDFIIRDLKLISTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVEKNshqfdIIGPIVVHCNNGIGRTGVYCALHALWQQITQ
||..  |.|.|.|..  .|. .  |.....||  ||.|| | . ..||.....|.. ..|.|..       |||||||..|||||| .  . .| ..|..
seksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleea.....eagpivvhCsaGiGRtGtfiviDillkliek

EKL
..|
kgl

subfamily_Ptp69D_pd Subfamily Ptp69D 393-611 2.1e-52 173.2 In-house 53-265 (307) alignment
Range on Protein: 393-611
Range on HMM: 53-265/307.0
RVPRICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVhDTAHFGDYEVT
| . |   |. ||.| . .|.| |||||||.| |.  .. ||| | |...|  |.||||.. .   ||||  ..|....  . | |   |. ..||  |.
RyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie.devqygdilvk

MESETARGDFIIRDLKLISTKDPS----VIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVeknshqfdiIGPIVVHCNNGIGRTGVYCALHAL
. ||   .|.|||.|..  .|. |      |..  .|.. |..   | . ...|.|...|.| ..            .||||||..| ||.|.. ||  |
lvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln.........rsPivvhCsaGvgrsgifvaldsl

WQQITQEKLVSVYQTAWLQGHQR
.||. .|. |....|     .||
lqqlkaedkvdifetvkdLrsqR

0037934 (Phosphotyrosine protein) phosphatases II 389-612 9.3e-52 171.3 In-house 11-221 (243) alignment
Range on Protein: 389-612
Range on HMM: 11-221/243.0
VPLRRVPRICVIDSSRVRLyprpgeEGSDYINASYIDGFTRreaFIATQHPLQSTTMD----YWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPavhDTA
.. .|.. |   | |||.|      ||||||||..|... |   .||||.||..|. |    .|||.|......|||| ...| ..   . | |   .. 
lsknrysdilpydhsrvkl......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...gev

HFGDYEVTMESETARGDFIIRDLKLISTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESE-----VEKNShqfdiiGPIVVHCNNGIGRT
..||..||. ||.  .|...| |.|  .. . . |...|.|.| ||.|| | | . .|.....| |. .|     .....      ||..|||  |.|||
tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsg......gpvlVHCsaGvgRt

GVYCALHALWQQItqeKlVSVYQTAWLQGHQRP
|...|.  . ...   . |.....  |   |||
Gtliaaylmllll...g.vdleeavkllreqRp

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 3-340 3.5e-51 168.8 In-house 2-256 (392) alignment
Range on Protein: 3-340
Range on HMM: 2-256/392.0
EPIPYEAFRSHVKHLHAdcDYKFFMEFEGVHEKNKRLTWVqSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLA
.|||   | . |.. .      || ||  . . .   . | .||. |. |||. |.. || .||.| . ..   | |.|| |...... .||||.||| |
qpipvaqfpafveknrh..salffeefhdlpgpdiypqtv.aqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpna

KTISDFWRMIWEQNCRVIVMITNIIEKGrhkcamywptknrktenhgpltitfvqeetfayysirtfeikpnkdgthytqymhgtmfdssastnmlldes
 ...|||||....|   |.|.|.. |                                                                          
aslddfwrmvfqenvttiamvtklkegd........................................................................

ldpLDDEVKpmMVKQFHFTGWPDHGAPEpgFEFPVLDLIMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLV
     |...   | ||||| |||.. |.  .   .| .| .  |     | ||..||||||||.|  | |||.. . .    .|.|||.. ||..| ..|
...kgddar..tvaqfhftewPdkdvpk..htssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymv

QEECQYIFIHDTLAEYIACNFVIsLPIKALKDHVRMMR
| . || ||. .. | .    .. .|.  . ||.. . 
qtkeqyafiygavledllwrntl.ipvvhftdhlqdls

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 45-321 9.8e-51 167.3 In-house 29-268 (283) alignment
Range on Protein: 45-321
Range on HMM: 29-268/283.0
QKPENQMKNRFANVVAYDHSRVVLSLTENdqssHYINANYVD---TYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTk
   ||. |||. ..|..|  || |    .    .|||| ..     |.  . ||..|.|| .|. |||.|.....   |||.|.. |  | ||. |||  
sadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPk.

nRKTENHGPLTITFVQEETFAYYSIRTFEIKPNkdgthytqymhgtmfdssastnmlldesldplDDEVKPMMVKQFHFTGWPDHGAPEPGFEFPVLDLI
 | .|..|..|.|  .| |   ..|. . .. |                                    . ...  . . .| . |   .   .  ....
.rGsedyGeftvtlrkettsnsfiikelllrvn................................ssakstlllahyqvidWleygeqaiinslvkfnkv

mKSTACvVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHDTLAEYIAC
 .|        ||.|||||.|.||...|| . . .| .  .  .|.|. .  .|.||  .||.  || ..|.   |   |
.islqt.eskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalc

subfamily_PTPRA_pd Subfamily PTPRA 393-611 1.1e-50 167.4 In-house 63-274 (330) alignment
Range on Protein: 393-611
Range on HMM: 63-274/330.0
RVPRICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAvHDTAHFGDYEVT
||..|   | ||| | .. |.| |||||||.|||. ... |||.| |.. |  |.|||||. .  .||||   || ...    | |  . .  .|.  |.
rvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPd.eGlvtyGnirve

MESETARGDFIIRDLKLISTKDP---SVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESeveknshQfdIIGPIVVHCNNGIGRTGVYCALHALW
.| ||   |. .|.. .    |       |..| |||  ||. | |  .. .|.|. ||.. .        |    |||||||  |.|||| ...| |. 
vedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnq.......q..sagpivvhcsaGvGrtGtfivldavl

QQITQEKLVSVYQTAWLQGHQR
...  |..| |...      ||
ervkaerkvdvfefvkrlrlqr

subfamily_PTPN9_pd Subfamily PTPN9 397-611 1.2e-50 167.2 In-house 51-269 (297) alignment
Range on Protein: 397-611
Range on HMM: 51-269/297.0
ICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLP-AVHDTAHFGDYEVTMES
.  .|..|| |  ....| ||||||...||. ...|||||| ||. |. |.|||.|..... |||     |  .     | |   ...|.|||..|.  .
vlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnve

ETARGDFIIRDLKLISTKDpSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVEK---NSHQFDIIG-PIVVHCNNGIGRTGVYCALHALWQQ
   . |. .| |..  .|. . .|.. || || ||..| | |....|....|| |  . . |   ....... | ||||||  |||||| ...|    ..
veeeedykvrvleiknvkt.eesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsr

ITQEKLVSVYQTAWLQGHQR
. ..  | | .|  |   ||
leevgtvdvvetvkllrtqr

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 3-176 3.5e-50 165.9 In-house 3-173 (319) alignment
Range on Protein: 3-176
Range on HMM: 3-173/319.0
EPIPYEAFRSHVKHLHADCDYKFFMEFEGVHEKNKRlTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLA
..|. . .....|.|..  . ..  ||. ..| ..  |. ...|.||. |||. |..|||..|||||  .. ..| ||||...|.|.  ...||||.||.
teievqeLkerlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPle

KTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNrkTENHGPLTITFVQEETFAYYSIRTFEIKPNKD
.||.|||||.||... ..||.|.. ||.. |.  |||..|   |. | |..|  .||  . | || ........
ntiedfWrmvWeeessivvmltklveklkvklkkywpeen..feeyGrlivtleeeeeledyiirklklnkkss

subfamily_PTPN9_pd Subfamily PTPN9 26-178 4e-50 165.5 In-house 19-171 (297) alignment
Range on Protein: 26-178
Range on HMM: 19-171/297.0
FMEFEGVHEKNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITN
  |.. .....   |  .|... |  |||...|. ||..||||. ...|. | |||||.|| |.  .|.||||||| ||.||||||.|||...||||.| 
skeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttr

IIEKGRHKCAMYWPTKNRKTENHGPLTITFVQEETFAYYSIRTFEIKPNKDGT
..|.|| ||. |||... .....| |... |. |.   | .|..|||  |.. 
vvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvktee

0041856 (Phosphotyrosine protein) phosphatases II 49-323 4.4e-49 161.8 In-house 1-175 (182) alignment
Range on Protein: 49-323
Range on HMM: 1-175/182.0
NQMKNRFANVVAYDHSRvvlsltendqSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITniiekgrhkCAMYWPtknrktenh
|. |||. ... |||||           ..|||||... .   . .||||||| .|. ||.||..|.....||..|         . .|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

gpltitfvqeetfayysirtfeikpnkdgthytqymhgtmfdssastnmlldesldplddEVKPMMVKQFHFTGWPDHGAPEpgfEFPVLDLIMKSTAcv
                                                            |  . .. |.....|||||.|.      .||.| .  .  
............................................................ellerlgiqylylpwpDhgvpd...ldelldfieevle..

vpGTGPLVVHCSAGVGRSGAFIVIDSMIKRihdngDLDIFNFLAHIRNQRNHLVQEECQYIFIHDTLAEYIACNF
    || .|||||||||.|...... |.|.     ...... ....|..|.. |. . ||.|... | |.. .. 
..eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlallellllkk

subfamily_PTPN12_pd Subfamily PTPN12 399-610 6.6e-49 161.3 In-house 51-255 (290) alignment
Range on Protein: 399-610
Range on HMM: 51-255/290.0
VIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHDTAH-FGDYEVTMESET
  | ||| |    .|||||||||..| | . . ..||.| ||  |  |.|||||. | . .||.  | | .|     | |  ....  ||..|||.|.| 
PydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeek

ARG-DFIIRDLKLISTkdpSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESeveknshQ--FdiigPIVVHCNNGIGRTGVYCALHALWQQITQ
|   ||.|| ||.      .  |... ||. .||.|| | | ...|.|...|.| ..       .       |.||||  |.||||. .|.   .... .
avdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.......seda....PlvvhCsaGvGrtGtiiaidyvrellka

EKL---VSVYQTAWLQGHQ
||.   ..|..  .   .|
ekipeeldvfdlvlelrkq

subfamily_PTPN23_pd Subfamily PTPN23 397-596 3.1e-48 159.1 In-house 52-243 (288) alignment
Range on Protein: 397-596
Range on HMM: 52-243/288.0
ICVIDSSRVRLYprpgEEGSDYINASYIDGFTRR-EAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHD-TAHFGDYEVTME
|   |..|| |     ..  ||||||.. . .     ||||| |||||  |.|.|....  . ||||||..| .|    .| |. .. | .|||..||..
ilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlk

SETARGDFIIRDLKLiSTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVEKNSHQfdiigPIVVHCNNGIGRTGVYCALHALWQQITQ
|..  . .. |.||| .|.|.. .....| ..  |||.| | | .|.||.. .||.  ..|...|..     |.||||  |.|||||.. . |  .....
svretethvervlkl.etldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrkskt.....PlvvhCsaGvgRtgvfalvyaavrelek

EK
..
gn

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 26-185 7.2e-48 158.3 In-house 33-191 (298) alignment
Range on Protein: 26-185
Range on HMM: 33-191/298.0
FMEFEGVHEKNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITN
| ... | .. .. ..  ..||||. |||.|...|.|.|||||. ...|. | |||| ....|.  ||.||||.|| .|..|||||..|..  .|||.||
fqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltn

IIEKGRHKCAMYWPTKnrKTENHGPLTITFVQEETFAYYSIRTFEIKPNK-DGTHYTQYMH
. |... |.  |||..  ..|..| .|..  ..|.|| . .|..... .| ....  . .|
leeldktkyhkywPde..gketygeitvsllskeefadlivrklkvskkkeekerevrqlh

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 10-174 1.1e-47 157.5 In-house 2-165 (281) alignment
Range on Protein: 10-174
Range on HMM: 2-165/281.0
FRSHVKHLHADCDYKFFMEFEGVHEKNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFW
.| |.|.|... .  | .|.|.... . . | . |...||..|||. |.||||..||... .|..... |||||.|..|.  ..|||||||. ... .||
lrkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafW

RMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNRkTENHGPLTITFVQEETFAYYSIRTFEIKPN
.|.|||. ..|||.|. ||.|. ||  ||| .|  . . | .|.....||. | |  |.|... .
qmvweqkvsaivmvtreieagklkChrYWPddns.elkygdvtvkstaeeekatyierkfklere

0051429 (Phosphotyrosine protein) phosphatases II 77-320 4.4e-47 156.3 In-house 4-226 (272) alignment
Range on Protein: 77-320
Range on HMM: 4-226/272.0
SHYINANYVDTYNA---MNAYIATQGPLAKTISDFWRMiWEQNCRVIVMITNIIEKGRHKCAMYWP----------TKNRKTENHGPLTITFVQEETFAY
|.||||..|..|.     .......|||  |. ||||. .|.....||....  |.||.|| .|||               | ..| |..|...||.. .
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

YSIRTFEIKPNKDgthytqymhgtmfdssastnmlldesldplddEVKPMMVKQFHFTGWPDHGAPEPGfEFPVLDLIMKstacvvpgTGPLVVHCSAGV
| .|.....   .                                  ....| ..|.|.|||||.|.      .|.|. .         ||..||||||.
yilrellltllls................................agearevmhlhytdwpdhgvpqea.llellellld........ggpvlvHCsaGk

GRSGAFIVIDSMIKRIHDNGDLD--------IFNFLAHIRNQRNHLVQEECQYIFIHDTLAEYIA
.|.| ..... .. .....  .|        ........| || . || | ||.|... |.|.. 
dRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellr

subfamily_PTPRA_pd Subfamily PTPRA 1-179 5e-47 155.4 In-house 10-186 (330) alignment
Range on Protein: 1-179
Range on HMM: 10-186/330.0
KHEPIPYEAFRSHVKHLHADCDYKFFMEFEGVHEKNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGP
|. |.| | .   ..   ||   .|  ||. .   . . |   ..| ||. |||. |.. ||.|||.||  |  ..| |||| ..| |.  . .||.|||
kyfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGP

LAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNRKTenHGPLTITFVQEETFAYYSIRTFEIKPNKDGTH
...|. |||||||||.   |||.|.. |. ..||| |||..   |  .| ....  .|.    |..| | ..   |.|.
keetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvt..yGnirvevedetvlvdytvrkflvqqlpdatr

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 2-176 5.8e-47 155.1 In-house 3-173 (315) alignment
Range on Protein: 2-176
Range on HMM: 3-173/315.0
HEPIPYEAFRSHVKHLHADCDYKFFMEFEGVHEKNKRlTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPL
|.||| . . ..| . .|     |  ..| .   . .     ..| ||. |||. |..|||.||| | |.|||. |.|.|||..| ||  . |||.|||.
hqpipldqlityvaqkkastkngfkqdyesipggqlh.pldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpn

AKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKnrkTENHGPLTITFVQEETFAYYSIRTFEIKPNKD
. .. ||||...|...  |||.||..|. ..|.  ||| |      .|..|.| ..|| .  |..||. .  ...
vasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGkitvtrkseevnteytvrtlsvvfgdn

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 12-191 8.5e-47 154.6 In-house 10-188 (288) alignment
Range on Protein: 12-191
Range on HMM: 10-188/288.0
SHVKHLHADCDYKFFMEFEGVHEKNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRM
..|.. .|.    |  |.. . . .|  .  ......|. |||. |...||. || |   |. ... ||||.|.| .. ...|||||||||.|. |||..
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWel

IWEQNCRVIVMITNIIEKGRHKCAMYWPTKNrKTENHGPLTITFVQEETFAYYSIRTFEIKPNKDGTHYTQYMHGTMFDS
..|..   |||.|...|.|..||  |||... | .|.| .|.| |....   .  |..... .|.  . ||| . .  | 
vyenktstivmltelveggktkCeeYWPdad.kpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdh

0049772 (Phosphotyrosine protein) phosphatases II 38-319 1.3e-46 155.2 In-house 35-280 (314) alignment
Range on Protein: 38-319
Range on HMM: 35-280/314.0
RLTWVQSQKPENQMKNRFANVVAYDhSRVVLSlTENDQSSHYINANYVDTYnamNAYIATQGPLAKTISDF----------WRMI--WEQNCRVIVM---
.||........|. |||. ... .| .||.|. ... ..| ||||.|||..   ...|||||||  |. ||          |||.  ...|.|.|||   
eltilvadlflnrdknryldilpad.nrvilp.glpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrd

------------------ITNIIEKGRHKCAMYWPTKNrktenhgpltitfvqeetfayysirtfeikpnkdgthytqymhgtmfdssastnmlldesL-
                  .... ..| . .|..... .                                                              
evladelsrLdaAlgKtpllildgngneptaadlellk............................................................ee

--DPlddEVKPMMVKQFHFTGWPDHGAPEPGFEFPVLDLIMKStacvvPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIhdngDLDIFNFLAHIRNQRN--
  ||   |  . .. ... . .||..|| . .   .|..| .      .  ||..|||.||.||.| |.|.. ..|.     ....   |...|..|   
lydp...elferlgikylripvpDgsaplledfdeflefieea.....dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpin

---HLVQEECQYIFIHDTLAEYI
   ....  .||.||.. | ||.
pnpgfieqleqyefilealleyl

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 393-603 1.6e-46 153.7 In-house 52-250 (288) alignment
Range on Protein: 393-603
Range on HMM: 52-250/288.0
RVPRICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHDTAHFGDYEVT
| . |  .|  ||.|   . |.|.||||||||||  .....|||| ||..|  |.|.......   |||| .  | .|     | |. ..  ..|. .||
RyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvt

MESETARGDFIIRDLKLIstKDpSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVeknshqfdiIGPIVVHCNNGIGRTGVYCALHALWQQI
. ..   .||. | | |   |.    ..| ....| ||.|| | | . .|.|...|.  ...           |||.||| .|.||||.. ||.|| ...
lveskeledfvlrkllle..kk.kteleitqyqylaWpdhgvPeskapllellrqvkvanqad.........tgpiivhCsaGvGrtgtFialdalidav

TQEKLVSVYQT
 .|. . |  |
eeedyiDvagt

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 397-602 3.9e-46 152.3 In-house 37-238 (274) alignment
Range on Protein: 397-602
Range on HMM: 37-238/274.0
ICVIDSSRVRLYPRPGEE-GSDYINASYIDGFTRR-EAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHDT---AHFGDYEV
|   . ||| | .. .|.  |.|||| || |. .. .|..||| ||..| .|.||||.||... ||||   || ...    | |  .|.    ..|| |.
ilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdvei

TMESETARGDFIIRDLKLISTKDpsvIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVeeweseV----EKNSHqfdiIGPIVVHCNNGIGRTGVYCALHA
..|. . | |. .| | | ....    |.. |. . .||.| .| . .|.|.|| .|           |.| .    ..|.||||  ||||||.. | . 
kvekiverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvlev......eesreeenak....lapvvvhCsaGiGrtGcfiaisi

LWQQITQEKLVSVYQ
  .|. .|. | | .
avrqlreeivvdvlk

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 388-612 6.8e-46 151.4 In-house 46-263 (290) alignment
Range on Protein: 388-612
Range on HMM: 46-263/290.0
GVPLRRVPRICVIDSSRVRLYPRPGEEG--SDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVhDTAH
  .|.|  .| | |  |. | | .|..    .||||.||.|.  ....|||| |...| .|.|..||||..  ||||....| .|..   | |.  ||..
nkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds.dtka

FGDYEVTMESETARGDFIIRDLKLISTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESeveKNSHqfdiiGPIVVHCNNGIGRTGVYCAL
.| ..... .|..  ..|.| |.. ...     ... ....  |...|.    ||.|........ .    |.       ..||||| ...||..|.||.
ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqr...krgn.....tsivvHCSdtvgrsavfcaa

HALWQQITQEKLVSVYQTAWLQGHQRP
.   ..  .|  . |.|    |  |.|
attinkcktegvidvfqvlksqRiqkp

subfamily_CG7180_pd Subfamily CG7180 398-604 1.5e-45 150.1 In-house 52-262 (296) alignment
Range on Protein: 398-604
Range on HMM: 52-262/296.0
CVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKdVFPSYLPAVHdTAHFGDYEVTMESET
   |  || |    ||| ||||||.|.|.|.. ...| |. | ..|  ..||....|.. ..|.|  . .  |  .|||.|     ...|. .| . .| 
vPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks.keqygeifveiveek

ARGDFIIRDLKLIST---------KDPSVIRQIRHFHFLHWPE-HGQPWSGQTVLQLVSKVEEWESEVeknsHQFDIIGPIVVHCNNGIGRTGVYCALHA
   .. || .||  .         .     | ...|..  |.  .  |.| .....|. .|. |  .|    .. .  ||.||....| .|.|||.|. |
qyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekv....dedpeegPvvvvssdGasRsGvylaida

LWQQITQEKLVSVYQTA
  ... .|. | |.. .
nlelvekeeevdvFeav

0036282 (Phosphotyrosine protein) phosphatases II 77-313 1.7e-44 146.9 In-house 2-164 (174) alignment
Range on Protein: 77-313
Range on HMM: 2-164/174.0
SHYINANYVDTYNAMNAYIATQGPLAktisdFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTknrktenhgpltitfvqeetfayysirtfeikpnkd
|.||||...| .   . .||.|||||     ||.|..|......|| .. .|.|..||  |||.                                    
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................

gthytqymhgtmfdssastnmlldesldplDDEVKPMMVKQFHFTGWPDHGAPEPGFEFPVLDLIMKSTACvvPGTGPLVVHCSAGVGRSGAFIVIDSMI
                              . |    .. |.....|||||.|.    . ..... .  .   .. ||..|||||||||.|...... |.
..............................lredlerlgiqylylpwpDhgvpdlsillefvkfveealse..dpggpvlVHCsaGvgRtGtlvaaylml

KRIHdNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHD
.... ..  |...... .|.|| . || . ||.|...
rgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy

subfamily_PTPN12_pd Subfamily PTPN12 36-185 2.8e-44 146.1 In-house 27-177 (290) alignment
Range on Protein: 36-185
Range on HMM: 27-177/290.0
NKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCA
.|  .  ...|.||. |||. ... ||.|||.|| .|... | |||||..   .   .|||.||||.||..||||||||.| ...||. ...| |..||.
ekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCe

MYWPTKNRKTENHGPLTITFVQEETFA-YYSIRTFEIKPNKDGTHYTQYMH
 ||| .. .. ..|....|  .|...   . |||.... .|.  . .|. .
rYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhY

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 397-604 6.2e-44 144.9 In-house 52-248 (515) alignment
Range on Protein: 397-604
Range on HMM: 52-248/515.0
ICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPA-VHDTAHFGDYEVTMES
|  .||.||.|     .  |||.||||| .|    |.||.| |..... |.||...|||   |.|.   || ||     | |    |. .|| ..| . |
ilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvs

ETARGDFIIRDLKLISTKDpsvIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVeewesevEKNSHQFDiiGPIVVHCNNGIGRTGVYCALHALWQQITQE
  | .. |.| |...  .|   .| .  |||  ||..| |   ...|.|. .|         .  |.    |...||  |.|||||.....    .. . 
leactggikrkltvlkgdd...srtvtqfhfteWPdkGvpkhtssllklikev.......kadhgqyt..hpliihcsaGvGrtGvvisidsvvahaktt

KLVSVYQTA
. | |... 
rmvdvfnfv

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 5-184 6.4e-44 145.0 In-house 2-180 (290) alignment
Range on Protein: 5-184
Range on HMM: 2-180/290.0
IPYEAFRSHVKHLHADCDYKFFMEFEGVHEKNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLS-LTEN-DQSSHYINANYVDTYNAMNAYIATQGPLA
|| . |  .| . ||  . .|  .|. ..  ..  |      ..|. .|||||.| ||  |..|  .... | . .|||| |.. |.  ..|||||||. 
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

KTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKnrKTENHGPLTITFVQEETFAYYSIRTFEIKPNKDGtHYTQYM
.|. |||..||.... .|||.|||||.|..||  |||..  .|.. |. .|. ..|||. .| .|..|.| .. . ...| .
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds..dtkaygefsikllneetlneyierklevknknsa.gakqsv

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 44-179 6.8e-44 144.9 In-house 4-136 (250) alignment
Range on Protein: 44-179
Range on HMM: 4-136/250.0
SQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHkCAMYWPTKnr
..||.|. |||.|...|.|.|||||  .. |. | |||| ....|.  .|.||||||| .|| |||||..|..  .|||.||. |...  .  |||..  
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve..

KTENHGPLTITFVQEETFAYYSIRTFEIKPNKDGTH
|.|..| .|..  ..|.|| | .|.. .  .|   .
kaekyGdvtvsllskeefadytkrklklskakkade

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 13-183 8.1e-44 145.0 In-house 13-182 (325) alignment
Range on Protein: 13-183
Range on HMM: 13-182/325.0
HVKHLHADCDYKFFMEFEGVHEKnKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMI
||.. .|. .  |  ||. .  .    .   . ||||. |||| ||||.|.|||||   ..| || ||||.|. ..   . ..|.| ||..|| |.||..
hvekkkaqdqdgfahefgllpsd.dgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlv

WEQNCRVIVMiTNIIEKGRHKCAMYWPTKNRKTENHGPLTITFVQEETFAYYSIRTFEIKPNKDG-THYTQY
 . .| |.|. .|....| ..||.||| .  |. . |.| . ..  |... |  | ...|  |.| |   . 
ldWrcsvvvv.lneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkq

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 4-183 2.3e-43 143.5 In-house 3-183 (305) alignment
Range on Protein: 4-183
Range on HMM: 3-183/305.0
PIPYEAFRSHVKHLHADCDYKFFMEFEGVHEKnKRLTWVQsQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAK
.|  . . ...|. ... | .. .... . |. .  . |. .| .|. |||..... .|..|. |. .|... |.||||.|||.|.  ..||..|||| .
iialddlaayikearvysdkgleaqykslyee.eesidvg.kkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkn

TISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNRKTENHGPLTITFVQEETFAYYSIRTFEIKP---NKDGTHYTQY
|..||||.|.|   ..|||.|...| |..|| .|||.. ......|.....  .|.|.. | .| ..|     .|..   .||
tvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqy

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 397-603 2.5e-43 143.2 In-house 58-250 (315) alignment
Range on Protein: 397-603
Range on HMM: 58-250/315.0
ICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVhdTAHFGDYEVTMESE
|   | |||.|     ...|||.||..|||..... .||.| |. ..  |.||....|..  |||| .  | .|     | |       .| . ||. ||
iiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk..kviyGkitvtrkse

TARGDFIIRDLkliSTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESevekNSHqfdiiGPIVVHCNNGIGRTGVYCALHALWQQITQEK
    .. .| |   |.   . ||..  .|.  ||. | | .  ....|. .|  ..     ||      |.|||||..|.|||| ...| |. .|.  |.
evnteytvrtl...svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhht....nsv.....gaivvhcsaGvGrtGtfitldavldqaeaen

LVSVYQT
.. ||. 
aidvynf

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 393-596 2.7e-43 143.1 In-house 46-239 (281) alignment
Range on Protein: 393-596
Range on HMM: 46-239/281.0
RVPRICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHDTAHFGDYEVT
|   |.  | .||.. |   .. .|||||....|..  ...|||| |. .. ...|.|.|... . |||.  | | .|     | |  . . ..||. |.
rYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvk

MESETARGDFIIRDLKLisTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVEKnshqfdiiGPIVVHCNNGIGRTGVYCALHALWQQI
...|...  .| | .||  ... .  |........ ||.|| | . . .|.  ..|.. ... .|         |.|.||  |.||||.| ||  | ...
staeeekatyierkfkl..eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktk........aplvihCsaGvGrtGtyialDrlvkav

TQEK
..|.
eael

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 392-611 3.6e-43 142.6 In-house 51-257 (287) alignment
Range on Protein: 392-611
Range on HMM: 51-257/287.0
RRVPRICVIDSSRVRLYprpgEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHDtAHFGDYEV
 |. .| | |  || |     .|  |||||..|||.  . |||... |. .|  ..|..|...|   ||||  ||| |..|   | |  .    .|.|..
nRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyni

TMESETARGDFIIRDLKLISTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEwesEVEKNSHqfdiiGPIVVHCNNGIGRTGVYCALHALWQQ
.. .|.   ..|.|.|... ..  .  .|.. ...  |...|.  . ||.| .. .      .  |...     ..||||| ...||....||     ..
ellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyk...tqrkrgn.....tsivvhCsdtvGrsamfcaaattink

ITQEKLVSVYQTAWLQGHQR
  .|  . |.|    |  |.
ckteGviDvfqvlksqriqk

0043147 (Phosphotyrosine protein) phosphatases II 74-312 4e-42 139.2 In-house 2-154 (172) alignment
Range on Protein: 74-312
Range on HMM: 2-154/172.0
DQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIiekgrhkcamywptknrktenhgpltitfvqeetfayysirtfeikp
|..|.||||.|.|.|  .. .|||||||  |..|||||..|.....||..|.                                                
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...............................................

nkdgthytqymhgtmfdssastnmlldesldPLDDEVKPMMVKQFHFTGWPDHGAPEPGFEFPVLDLIMKSTacVVPGTGPLVVHCSAGVGRSGAFIVID
                                .| |    .. |.....|||||.| . .   .|..| .    ..   || .|||||||||.|......
...............................lydpellerlgiqylylpwpDhgvpllellleflefidell..alspggpvlVHCsaGvgRtgtlvaay

SMIkrihdnGDLDIFNFLAHIRNQRNHLVQEECQYIFIH
 |.       .|.... .|..|..|.. || . ||.|..
lml......lglsleeavalvrekRpgavqnpsqyrfly

subfamily_PTPN3_pd Subfamily PTPN3 26-176 4.2e-42 139.0 In-house 18-167 (280) alignment
Range on Protein: 26-176
Range on HMM: 18-167/280.0
FMEFEGVHEKNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENdqssHYINANYVD----TYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIV
...|| .. |.. |.  ...||||  |||. ....||. || |. .|.     |||||||.    . ...| ||||||||||| .|||.|.|||....||
laqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssliv

MITNIIEKGRHKCAMYWPTkNRKTENHGPLTITFVQEETFAYYSIRTFEIKPNKD
|.|...|.|| ||  |||. . .. ..| ....  .|..   | .| . .| .. 
mlttlverGrvkChqyWPe.tedeleygefsvkcekedetksyvlrelvlkdket

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 207-341 9.1e-42 138.2 In-house 169-301 (318) alignment
Range on Protein: 207-341
Range on HMM: 169-301/318.0
DDEVKPMMVKQFHFTGWPDHGAPEPGfeFPVLDLIMKSTACV-VPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEE
..| .  .|.|.|.| |||.| || |    .|||. ....    .|.||.|||||||||| | ||..|....||.... .|.|..  ..|.||| .|| |
teeeesrqvrqyhytsWpdegvpesg..aslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqte

CQYIFIHDTLAEYIACnFVISLPIKALKDHVRMMRM
 ||.||.|.| |..|. .      . |....| .| 
dqyefiydvllealas.gdtevdasdlrsrirelre

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 397-604 9.9e-42 137.9 In-house 53-249 (315) alignment
Range on Protein: 397-604
Range on HMM: 53-249/315.0
ICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPA-VHDTAHFGDYEVTMES
|  .||.||.|     .  ||||||||| ..   .|.||.| ||...  |.|||..||.  .|||.   .| ||     | |    |...|| ..|.. |
ilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvells

ETARGDFIIRDLkliSTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEeweSEVEKNSHqfdiigPIVVHCNNGIGRTGVYCALHALWQQITQE
  | .| ..| |    |..    |..  |.|  ||..| .    ..|.|. .|    .. .|. .      ...|||  |.||||| ....   .|| ..
leadtdgvarkl...vtrkseesrtvtqfqftewPdkGvdkqtssllklikevk...adngkkef......sllvhcsaGvGrtGvvisidevvaqikrt

KLVSVYQTA
. | |... 
rsvdvfnfv

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 399-604 1.1e-41 137.9 In-house 62-256 (297) alignment
Range on Protein: 399-604
Range on HMM: 62-256/297.0
VIDSSRVRLYPRPGEEGSDYINASYIDGFTRreAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKdVFPSYLPAVHdTAHFGDYEVTMESETA
 .|||||.|  .  .  |||.|||.. |.     .|.|| | ..|  |.|.|...|.   ||||  ..| ||     | .    .. |||  |...| . 
PydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkg.vttfGdvsvvllsvse

RGDFIIRDLKLiSTKDPSVIRQIRHFHFLHWPEHGQPW--SGQTVLQLVSKVEEweseveknSHQFDIIGPIVVHCNNGIGRTGVYCALHALWQQITQEK
|  || |.|.. .  .. . | .. ..|..||..  .   | ...|.|.| |..        ...    ||..||| .|.|||||....     .. .||
reGfikrelev.tkgkakarrvvkqyqfveWPdkaverkdsassllklisevrk........dfsqnaegPllvhclaGvGrtgvlltidsvvaeakrek

LVSVYQTA
 | .... 
evdifglv

0046846 (Phosphotyrosine protein) phosphatases II 72-318 1.6e-41 137.3 In-house 7-172 (176) alignment
Range on Protein: 72-318
Range on HMM: 7-172/176.0
ENDQSSHYINANYVDTYnamnAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTknrkTENHGPltitfvqeetfayysirtfei
  | ...|||||.....    ..||||||| .|. ||..|..|......|..|. .|.||.||. |||      |..|                      
gldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe....leklgi.....................

kpnkdgthytqymhgtmfdssastnmlldesldplddevkpmmvkQFHFTGWPDHGAPEPGFEFPVLDLIMKstacVVPGTGPLVVHCSAGVGRSGAFIV
                                             |.....|||||.|.    . .|..| .    ..   || .||||||.||.|....
.............................................qylhlpwpDhgvpdlelllellefire....alkeggpvlVHCsaGigRtgtlva

IDSMIKrihdNGDLDIFNFLAHIRNQRN-HLVQEECQYIFIHDTLAEY
.. ...    . .|.... ||..|.||  . || ..|| |... . ..
ayllel....ekglsveealalvreqRplgavqtpeQyrflyefelll

0049260 (Phosphotyrosine protein) phosphatases II 84-313 3.8e-41 135.6 In-house 1-144 (152) alignment
Range on Protein: 84-313
Range on HMM: 1-144/152.0
YVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWptknrktenhgpltitfvqeetfayysirtfeikpnkdgthytqy
..| |. ....||||||.  |..|||||..|.....|||.|.  |.|. ||..|.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

mhgtmfdssastnmlldesldplddevkpmmvkQFHFTGWPDHGAPEPGFEFPVLDLIMKSTacVVPGTGPLVVHCSAGVGRSGAFIVIDSMIkrihdnG
                                 |.... |||||.|.  . .. | |...         || .|||||||||.|...... |.       
.................................qylhlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......l

DLDIFNFLAHIRNQRNHLVQEECQYIFIHD
........|..|..|.. |. . |..|...
gvsleeavalvrekRpgavpnpgqlrflye

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 18-182 1e-40 135.0 In-house 29-189 (319) alignment
Range on Protein: 18-182
Range on HMM: 29-189/319.0
HADCDYKFFMEFEGVHEKNKRLTW-VQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQN
  |   |. .||  . ..   |.    .  ..|. |||. |..|.|...| |  ..  . | |||| .|. |   . |||.||||  |. ||||||||.|
fdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyn

CRVIVMITniiekgRHKCAMYWPTKNRKTENHGPLTITFVQEETFayYSIRTFEIKP---NKDGTHYTQ
|  ||..|      ..||. ||| |  ..|... . .. |.|     | .| .|.     .||  . ||
cstivllt......kdkcsqywplkivikeerfkvkvdsveetae..yvvrdielsedgkekdirkitq

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 393-603 2.4e-40 133.7 In-house 53-259 (325) alignment
Range on Protein: 393-603
Range on HMM: 53-259/325.0
RVPRICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMI--WQencRSIVMLLSEKEWDKDVFPSYLPAV-HDTAHFGDY
| . .  .| ||| |  .  .  ||||||||.  . ... |.|.| || .|. | ||..  |.    |.|..| | . .||    | |    .. .||  
rfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr...csvvvvlneldlgkdrcavywpkemgksktfGgl

EVTMESETARGDFIIRDLKLISTKDPsVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVEKNSHQfdiIGPIVVHCNNGIGRTGVYCALHALW
|| . .     |.. | |..  .|.    | .. |..  |.. |..    |.. ..  |.. .  |  |..     .||.||| .|.|||||. .|... 
evklrtieeisdyvhrvldvkqvkkG.etrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantka...stpilvhcsaGvGrtGvfislysal

QQITQEKLVSVYQT
... .|  | ... 
akvieesrvdifgf

subfamily_PTPN3_pd Subfamily PTPN3 395-597 3.6e-40 132.7 In-house 48-240 (280) alignment
Range on Protein: 395-597
Range on HMM: 48-240/280.0
PRICVIDSSRVRLYprpgEEGSDYINASYI----DGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHDTAHFGDYE
  |.  |. ||.|     |. .|||||.|.    .. .    .|||| ||..|. |.|.|.|..... |||| .  |  .     | |  .|. ..|...
rdilpydatrvklk....esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPetedeleygefs

VTMESETARGDFIIRDLKLISTKdPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWEseveknshqFDIIGPIVVHCNNGIGRTGVYCALHALWQ
|..|.| ..  ...|.| |  ..  .  |.| .. .| ||.|| | . . .|..|..|..                |.||||  |||||||. .|    .
vkcekedetksyvlrelvlkdke.tkeerkilqlqylaWpdhgvPddsadflefvervrklr.........sgkeePvvvhCsaGigrtGvlilletala

QITQEKL
 | ... 
lieaaep

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 44-182 1.8e-39 130.9 In-house 20-153 (284) alignment
Range on Protein: 44-182
Range on HMM: 20-153/284.0
SQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITniiekgRHKCAMYWPTKNR
.  ..|. |||. ...|.|...| |  .   . | |||| ..  |   . ||||||||  |. ||||||||.||  ||..|      ..||. ||| |  
anldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkiv

KTENHGPLTITFVQEETFayYSIRTFEIKP---NKDGTHYTQ
..|... . .. |.|     | .| .|.     .||  . .|
ikeerfkvkvdsveesee..yvvrdielsedgkekdirkirq

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 394-606 2.6e-38 126.6 In-house 9-213 (237) alignment
Range on Protein: 394-606
Range on HMM: 9-213/237.0
VPRICVIDSSRVRLYPrPGeEGSDYINASYIDGFTR-REAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHDTAHFGDYEVT
   | . | ||| |   .|  |||||||.|..||      .||.| ||.|.  |.|.|.|||.|  ||||    | ..     | |  .. | .| . |.
ygnivaydhsrvvlkg.ag.sgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltvs

MESETARGDFIIRDLKLISTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVeeweseVEKNSHqFDIIGPIVVHCNNGIGRTGVYCALHALWQQI
.  . .  |. .| | |        .| |  ..|  ||..| |    ..|..  ..      .... |     || ..||. |.||||..  . |. .| 
lkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkni......inrsph.vsesgpwiihcsagvgrtgiflvidamlrqa

TQEKLVSVYQTAWL
 ..|.| .|.  . 
kekkvvdiynyvys

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 5-183 1e-37 124.7 In-house 2-178 (287) alignment
Range on Protein: 5-183
Range on HMM: 2-178/287.0
IPYEAFRSHVKHLHADCDYKF---FMEFEGVHEKNKRLTWVQSqkPENQMKNRFANVVAYDHSRVVLSltenDQSSHYINANYVDTYNAMNAYIATQGPL
|| | |   |.. ||  .  |   |. .| | .... .|   .  ..|. |||..... .|  ||.|     ..   |||| ..|.|.  .|.|....|.
ipvekfgefvakghakgnegfknqftvleqvtqredevthnia..sqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPm

AKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNRktENHGPLTITFVQEETFAYYSIRTFEIKPNKD-G--THYTQY
..|. .||..|...|  .|||...  |. ...|  |||...      |. .|....||. | | .|..|.| ..  |   . .||
fntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellneevnagyierklevknknkagdkqqvkqy

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 48-320 1.6e-37 124.0 In-house 46-345 (350) alignment
Range on Protein: 48-320
Range on HMM: 46-345/350.0
ENQMKNRFANVVAYDHSRVVLS--------LTENDQSSHYINANYVDTY------NAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHK
|   |||. |.. |.|||| |              ... ||||||.         |.   |||||.|| .|. ||...| . . .||...|. .| ...|
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek

CAMYWPTKNRKtENHGPLTITFVQEETFAYYSIRTFEIKPNKD-GTHYTQYMHGTMFDSSASTNMLLDEsldplddevkPMMVKQFHFTGWPDHGA-PEP
|  ||.  . . . .  |. .  .       |......| .       ..  .   ..|  . ..   .          |..| |...  |.| .   .|
cyrYWqegsyd.ditvklaskwenimgindsslysadvkkeasdndnisddndlkdnnsltaitlaasd..........PyvvyqlqvknWkDlslllnP

GFEFPVLD----LIMKSTA---CVVPGTGPLVVHCSAGVGRSGAFIVIDSMIK------RIHDN-GDL--------DIFNFLAHIRNQRNHLVQEECQYI
    ..|.    || . .|        . |..||||||||| | .. .||...       . ..   |         |.  . ..|.||  .||.  |.|
esilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfi

FIHDTLAEYIA
||...|  | |
fiYeallfyfa

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 393-602 5.2e-37 122.1 In-house 45-263 (301) alignment
Range on Protein: 393-602
Range on HMM: 45-263/301.0
RVPRICVIDSSRVRLYPRPG--EEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPA-VHDTAHFGDY
|   | |.|  |. | | |       .|||||||||......|||.| |...| .|.||.||||   ||||.  .||  |.    | |   ... .||  
rfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpf

EVTMESETARGDFIIRDLKLISTKDPS---V-----------IRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVEKnshqfdiiGPIVVHCNNG
.||. .|..  ||.||.|... ..  .   .            ...  ..   ||..|     .|||| . .|   .  ...        ||.|||| ..
tvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigg........gpvvVHCSdt

IGRTGVYCALHALWQQITQEKLVSVYQ
..|.||||..     |   |  | |.|
VsrsGvYcsvsiglEQckaegVVdvfq

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 203-337 8.3e-37 121.9 In-house 168-300 (319) alignment
Range on Protein: 203-337
Range on HMM: 168-300/319.0
LDPLDDEVKPMMVKQFHFTGWPDHGAPEPGFEfpVLDLIMKSTAC-VVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHL
|... .||.  .||.|..| ||||. || .    .|||. .       .  ||.|||||||||| |.|||.| |. |.. .| ||.|..  ..| ||| .
lnkkssevetRevkhfqyteWpdhdvPekats..lldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnim

VQEECQYIFIHDTLAEYIACnFVISLPIKALKDHVR
||.. ||.||...| |.. . .   . .. |.| ..
vqrpeqYkfiyealleavea.gdteievqdlrdrlk

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 392-604 1.6e-36 120.7 In-house 37-238 (283) alignment
Range on Protein: 392-604
Range on HMM: 37-238/283.0
RRVPRICVIDSSRVRLYPRPGeegsDYINASYID---GFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAvHDTAHFGD
 |   | . |  ||.| . .     |||||..|       . . .|..| ||. | .|.|.|...|.  .||||   .|  .     | |  . .  .|.
nrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPk.rGsedyGe

YEVTMESETARGDFIIRDLKLISTK-DPSVIRqIRHFHFLHWPEHGQpwsgQTVLQLVSKVEEWESEVEKNSHqfdiiGPIVVHCNNGIGRTGVYCALHA
. ||.. ||.   |||. | |       | .  . |. .  | | |.    |...  . |..   |   .. .     ||||||| .|||||.|..|. |
ftvtlrkettsnsfiikelllrvnssakstll.lahyqvidWleyge....qaiinslvkfnkvislqteskk.....gPivvhCstgiGrtavfiaasa

LWQQITQEKLVSVYQTA
  ...  | .| |... 
svkdaltesvvdvfavv

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 401-598 1.6e-36 120.7 In-house 33-230 (270) alignment
Range on Protein: 401-598
Range on HMM: 33-230/270.0
DSSRVRLYPRPGEEGSDYINASYIDGFTR-REAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHDT---AHFGDYEVTMESE
  .|||| .   .. . |||| |. ||.  ....||.. ||..|. ..|||||.|. ..|||.   .|  ..    | ||  ..    ..|. .|. .||
PatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalse

TARGDFIIRDLKLIstkDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLvSKVEEWESEVEKNSHQFDIIGPIVVHCNNGIGRTGVYCALHALWQQITQEK
. .  .|.. |.|    . . .|.. ||.. .||.|| | . ...|.  ... .   .| . ....|  .|..||| .|.||||.  ||    . . ..|
ekeegyiltrlrle...ekgeerrlvHfwyntWpdhgvpreedsslst.dqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetk

LV
 |
kv

0051429 (Phosphotyrosine protein) phosphatases II 415-599 4.6e-36 120.2 In-house 3-184 (272) alignment
Range on Protein: 415-599
Range on HMM: 3-184/272.0
GSDYINASYIDGFTR---REAFIATQHPLQSTTMDYWRMiWQENCRSIVMLLSEKEWDKDVFPSYLP-----------AVHDTAHFGDYEVTMESETARG
 |.||||....|..|   . .......||. |  |.||. .......||.| || | ... .. |.|            .. |  .|.. ||. ||.   
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

DFIIRDLKLISTKDPSVIRQIRHFHFLHWPEHGQPWSGqtVLQLVSKVEEweseveknshqfdiIGPIVVHCNNGIGRTGVYCALHALWQQITQEKLVS
|.|.| | |. . ... .|...|.|.. || || | .   .|.|.. . .               ||..|||. |..|||...||  | .... |  | 
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld..............ggpvlvHCsaGkdRTGtvvallllllgvsletivd

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 49-321 6e-36 118.9 In-house 43-273 (288) alignment
Range on Protein: 49-321
Range on HMM: 43-273/288.0
NQMKNRFANVVAYDHSRVVLSltenDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNRKTENH
|  ..|. |.   | .|| ||    | .  ||.|| | . .  .  | .| ||  ||  .|.|. |.. . |||.....|||..| | |.|.|  ..   
nptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekari

GPLtitfvqeetfayysirtfeikpnkdgthyT---QYMHgtmFDSSASTNMLLDESLDPLDDEVkpmMVKQFHFTGWPDHGAPEPgFEfPVLDLIMKST
| |                                 .  .    |     .. |     . ...|   .||. |.  |.|.| ||  .  . | |.    
grl.............................ctvvkkkr...adidklvkvsllriskegeekv...ivkilhlleWdddgvPen.yl.splrllevlk

ACvvpgTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHDTLAEYIAC
..    . |.|||.||||||.|..|.|  ... .  . .| | ..||. |..| . .| | ||...|  . |... 
sl....qkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelll

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 29-171 8.2e-36 118.3 In-house 16-159 (287) alignment
Range on Protein: 29-171
Range on HMM: 16-159/287.0
FEGVHEKN--KRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTeNDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNI
.. . |      .|. ....  .  |||.|.|. .|..||.|| .  .. | ||||||| .|.  .|.||.|||.| |. ||||...|..  .....|  
vdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsae.gelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtre

IEKGRHKCAMYWPTKnRKTENHGPLTITFVQEET-FAYYSIRTFEI
.|..| ||  ||| . ..    |  ... .. .     |..|.. .
veearlkcykywPer.evPmrvGGysvvlldydikePeygvralrl

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 396-598 8.9e-36 118.1 In-house 46-243 (287) alignment
Range on Protein: 396-598
Range on HMM: 46-243/287.0
RICVIDSSRVRLYpRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHDTAHFGDYEVTMES
 .  || .|| |    || ||||||| |. ..|. |||||.| |. .|  |.||......  |....  | |  .     | |  .     | | |.. .
dvlPiddtrvlls.aegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGGysvvlld

ET-ARGDFIIRDLKLISTkDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWeSEVEKNSHQfdiIGPIVVHCNNGIGRTGVYCALHALWQQITQ
 .    .. .| |.||   .    | .. ...| ||... . .   ....| .|..   |..... .   .||.|||.. ||||.|.. |. .| ..  .
ydikePeygvralrlidl.etrearvvkqldllswPdkvlaPtavglirfvldvkqh.ielardase...vGPlvvhddvGiGrsGillatlvlvsrled

EKLV
   |
lGrv

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 48-185 9.7e-36 118.1 In-house 19-159 (270) alignment
Range on Protein: 48-185
Range on HMM: 19-159/270.0
ENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVD-TYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNRK--
 ..  ||.|...   ..||.|.  |.|. . |||||||    .. ..|||..|||. |...|||||||.. . |||.|.. ||||.||..|||... .  
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekv

TENHGPLTITFVQEETFAYYSIRTFEIKPNKDGTHYTQYMH
. ..| .... ..||    | ..  ... . .  . . ...
kledgkikvlalseekeegyiltrlrleekgeerrlvHfwy

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 45-173 1.1e-35 118.0 In-house 4-130 (239) alignment
Range on Protein: 45-173
Range on HMM: 4-130/239.0
QKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNA-MNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNR
.|  |. |||.||.|.||||||||    ||  | ||||.|.  |.   .||||||| .. .  |||||.|..   ||||.| .||  ..||  |||    
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts

KTENhgpLTITFVQEETFAYYSIRTFEIKP
|  |   | .|. . | || | |||| .  
kycn...lrvtlrktevfadyiirtfvmsq

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 45-173 1.1e-35 118.0 In-house 3-129 (239) alignment
Range on Protein: 45-173
Range on HMM: 3-129/239.0
QKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNA-MNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNR
.|  |. |||.||.|.||||||||    ||  | ||||.|.  |.   .||||||| .. .  |||||.|..   ||||.| .||  ..||  |||    
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts

KTENhgpLTITFVQEETFAYYSIRTFEIKP
|  |   | .|. . | || | |||| .  
kycn...lrvtlrktevfadyiirtfvmsq

subfamily_PTPN14_pd Subfamily PTPN14 22-158 2.9e-35 116.7 In-house 22-161 (300) alignment
Range on Protein: 22-158
Range on HMM: 22-161/300.0
DYKFFMEFEGVHEKNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDqSSHYINANYVDTYN--AMNAYIATQGPLAKTISDFWRMIWEQNCRV
. | |.|.| . .|..  .   .. |||. |||| .|. |...|| || |... |. ||||  . .    .   ||..|||| .|. |||.|.|||. ..
egkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvql

IVMITNIIEKGRHKCAMYWPTK--NRKTENHGPLTITFVQE
|||.|...|.|..|.  |.| .  ..|| ..|   .|    
ivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfs

0044763 (Phosphotyrosine protein) phosphatases II 61-316 3.2e-35 116.7 In-house 2-168 (178) alignment
Range on Protein: 61-316
Range on HMM: 2-168/178.0
YDHSRVVLSLTENDQSSHYINANYVDTYnamnAYIATQGPlaktiSDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNRktenhgpltitfvqeet
.|..||.||  |. ..| ||||.... .     |.....|     .|......|.....||..|. .| |..||  |||...                  
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

fayysirtfeikpnkdgthytqymhgtmfdssastnmlldesldplddevkpmmvKQFHFTGWPDHGAPE-PGFEFPVLDLIMKSTAcvvPGTGPLVVHC
                                                        |......||||.|. . . . ....| .  .   .  || .|||
.......................................................iqylhipipDhgvpdllehflefvefieeald...ekggpvlVHC

SAGVGRSGAFIVIDSMIKRihdngDLDIFNFLAHIRNQRNhLVQEECQYIFIHDTLA
||||||||...... |.|.     .|.... ....|..|.  |. . |. ....   
saGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpgqlrqLyefel

subfamily_PTPRA_pd Subfamily PTPRA 209-341 1.1e-34 114.8 In-house 187-316 (330) alignment
Range on Protein: 209-341
Range on HMM: 187-316/330.0
EVKPMMVKQFHFTGWPDHGAPEPGFefPVLDLIMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQY
| |. .|.|||||.||| | |  .    .|.|. |  ..    .||.||||||||||.|.|||.|....|.. .. .|.|.|. ..|.|| ..|| . ||
ekksrlvrqfhftswPdvGvPfepi..GmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqy

IFIHDTLAEYIACNfVISLPIKALKDHVRMMRM
 ||. .| ||        | . .|. |.. .  
efiykvlleyylyg.dteldvsslekhlqklyn

subfamily_PTPN23_pd Subfamily PTPN23 30-176 4.4e-34 112.6 In-house 25-167 (288) alignment
Range on Protein: 30-176
Range on HMM: 25-167/288.0
EGVHEKNKRLTWVQSQKpENQMKNRFANVVAYDHSRVVLSltenDQSSHYINANYVDTYNAMN-AYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIE
|  ..|. | . .   |  .  |||. ... |||.||.|     ..   |||| .|    ..   .||||.||..|..|||.|..||  .||||...  |
eqkqdkearkrsiaiak.lyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskee

KGRHKCAMYWPTKNRKTENHGPLTITFVQEETFAYYSIRTFEIKPNKD
.|..|.. |||... .|...|.|..|  ....  ... |..... .. 
lgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletlda

0049772 (Phosphotyrosine protein) phosphatases II 392-600 4.8e-34 113.9 In-house 50-249 (314) alignment
Range on Protein: 392-600
Range on HMM: 50-249/314.0
RRVPRICVIDsSRVRLyPRPGEEGSDYINASYIDGFtrrEAFIATQHPLQSTTMDY----------WRMI--WQENCRSIVM------------------
 | ..|.  | .||.| |. . .|||||||||.|||    .|||||.||. |  |.          |||.  .. |.| |||                  
nryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlg

---LLSEKEWDkdvfpsylpA---------VHdtahfgdyevtmesetargdfiirdlkLISTKDPSVIRQIRHFHFLHWPEHGQPwSGQTVLQLVSKVE
   ||.  .           .          .                            . . .. . |.. ... ...| ...| . . .....  .|
Ktpllildgng.........neptaadlellk...........................eelydpelferlgikylripvpDgsap.lledfdeflefie

EWeseveknshqfDIIGPIVVHCNNGIGRTG--VYCALHALWQQITQEKLVSV
|.           |  ||..|||. |.||||  | .|.  . .... |. .. 
ea...........dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealed

subfamily_PTPN13_pd Subfamily PTPN13 28-177 7.7e-34 112.2 In-house 16-163 (273) alignment
Range on Protein: 28-177
Range on HMM: 16-163/273.0
EFEGVHEKNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSltenDQSShYINANYVDTYNA--MNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITN
||. ..|    .|  ...| ||. |||. ||. ||..|| |.    |... ||||...          |||.|||| .|..|||.|.|||...||.|.|.
efkelrelkpldtcevgkkkenkdknryrnvlPydetrvklg....degg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtl

IIEKGRHKCAMYWPTKNRKT-ENHGPLTITFVQEETFAYYSIRTFEIKPNKDG
  |||. ||  ||| ...|.   .. |... .. .    ...|....| .. |
ekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesg

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 4-185 8.3e-34 111.8 In-house 2-180 (315) alignment
Range on Protein: 4-185
Range on HMM: 2-180/315.0
PIPYEAFRSHVKHLHADcdYKFFMEFEGVHEKNKRLTWVqSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAK
|||   | . |.. .      |  ||  . . .   . | .....|. |||. |.. .|..||.| . ...  | |||| |. ...  .||||.||||  
pipvaqfpafvnknrht..alfseefhdlpdPdiyrqrv.aretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlka

TISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNRKTENHGPLTITFVQEETFAYYSIRTFEIKPNKDGTHYTQYMH
...|||||.....   |||.|.  |  . ||. ||| .. .. . | . .. .. |. .   .| . ..  ..    ||.  
svddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqf

subfamily_PTPRN_pd Subfamily PTPRN 392-593 8.8e-34 111.5 In-house 60-252 (297) alignment
Range on Protein: 392-593
Range on HMM: 60-252/297.0
RRVPRICVIDSSRVRLYPRPGEEGSDYINASYI-DGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHdTAHFGDYE
 |.  .   | |||.|  .  .| ||||||| | |   |. |.|||| || ||  |.|.|.|.. .  ||.| . .| .      | |    .. .. ||
nrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeG.sevyhiye

VTMESETAR-GDFIIRDLKLISTKDpSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEeweseveKnSHQFdIIGPIVVHCNNGIGRTGVYCALHALW
| . ||     |...| . |   .  |  | .  |||| |||.| | | ...|..  ||.       | |..     |||||| .| ||||||...  . 
vhlvsehiwcddylvrsfylknlqt.setrtvtqfhflswpeegvPasaksllefrrkvn.......k.syrG.rscpivvhcsdGaGrtGvyilidlvl

QQIT
....
nrll

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 211-321 1.1e-33 111.8 In-house 183-292 (298) alignment
Range on Protein: 211-321
Range on HMM: 183-292/298.0
KPMMVKQFHFTGWPDHGAPEPgfEFPVLDLIMKSTAcVVPGTG--PLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQY
|  .|.|.||| |||.|.||   .  ||||. |  |     .|  |..|.|||||||||.||.|||.. |.. .  .|.|. .  .|..| ..|| | ||
kerevrqlhftsWpdkgvpen..atsvldllrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqY

IFIHDTLAEYIAC
.||..   |....
vfiyeavlealds

subfamily_PTPN14_pd Subfamily PTPN14 393-602 1.3e-33 111.3 In-house 54-266 (300) alignment
Range on Protein: 393-602
Range on HMM: 54-266/300.0
RVPRICVIDSSRVRLYPRPGEeGSDYINASYIDGF--TRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAV---HDTAHFG
|.. .   . .||.| |   .  ..||||| |     ...  .|..| ||. |  |.|.|.|... . |||| .|.|  |.   .|.|     ..|..||
rfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefg

DYEVTMESETARGDFIIRDLKLISTKdPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVEKNSHQFDIIGPIVVHCNNGIGRTGVYCALHA
 ..|| .  .  . .| . |||      .  |.. |. .  ||.|| |   .. |. . .|.    ........ .   |..||| .|.|||||      
kfkvttkfsedsdsvittglklkhlp.skeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdl

LWQQITQEKLVSVYQ
| . . ... . . .
liatlehneeidikk

subfamily_PTPN13_pd Subfamily PTPN13 397-603 1.8e-33 111.0 In-house 46-240 (273) alignment
Range on Protein: 397-603
Range on HMM: 46-240/273.0
ICVIDSSRVRLyprpGEEGSdYINASYIDGFTRREA--FIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHDTA-HF-GDYEVT
.  .| .||.|    |.||. |||||.|      .   .||.| ||  |. |.|.|.|. ... |.|. .||| .|     | |  ..      . .||.
vlPydetrvkl....gdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrleve

MESETARGDFIIRDLKLISTKDpSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEveKnshqfdiiGPIVVHCNNGIGRTGVYCALHALWQQI
..  . . .| .|.|... ..  .  |.. |..| .||.|| | | . .||.|..| . ...  .        |||||||  ||||.|.. ..... . |
llkvqkldgfvvralavkdses.gesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtd..a........gPivvhcsaGiGrsGtlitidvvlgli

TQEKLVSVYQT
 ..| . | ..
erdkefdvkei

subfamily_PTPRB_pd Subfamily PTPRB 210-319 2.6e-33 110.3 In-house 176-285 (293) alignment
Range on Protein: 210-319
Range on HMM: 176-285/293.0
VKPMMVKQFHFTGWPDHGAPEPGFefPVLDLIMKST--ACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQ
 . . |.|.||| ||||| ||     ..||.. .    .     ..|.||||||||||.|.|| .| ....|...  .||| ..|..|..||.||| | |
keerkvrqyhftsWpdhgvPektk..tlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekq

YIFIHDTLAEYI
|||||... ...
Yifihqcvldll

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 211-321 8.5e-33 108.6 In-house 135-244 (250) alignment
Range on Protein: 211-321
Range on HMM: 135-244/250.0
KPMMVKQFHFTGWPDHGAPEpgFEFPVLDLIMKSTACVVP-GTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYI
.  .|.|.||. ||| | ||      ||.|. |  |     |..|..|.||||||||||||.||....|.. .  .|.|...  .|..| | |. . ||.
derivrqlhfvvWPdkgvPe..vatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyv

FIHDTLAEYIAC
|..  . ... .
fvyeiilkalds

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 209-339 8.7e-33 108.8 In-house 174-302 (305) alignment
Range on Protein: 209-339
Range on HMM: 174-302/305.0
EVKPMMVKQFHFTGWPDHGAPEpgFEFPVLDLIMKSTACVVPGTG-PLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQ
. .   | |...| ||||| |.  |   .|.|| . .     . | ||.|||||||||.|.||..| .. |..  . .|.|. | ..|..|  .||.  |
dkesrtvlqyqltdWPdhGvpq..fatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldq

YIFIHDTLAEYIACNfVISLPIKALKDHVRMM
| |.|| |.|.| |    |. .. |. .|  .
Yvflhdaldelitcg.dtsiigsnlrarvnkl

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 395-600 9.5e-33 108.3 In-house 55-247 (439) alignment
Range on Protein: 395-600
Range on HMM: 55-247/439.0
PRICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKdvfpsYLPAVHDTaHFGDYEVTME
  .   | .|| |   ||   | |||| ||.|.   . .|||| | . || |.||.......  ||||    |  |     | |.  ..  .||  | ..
kdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaev.cygdiavrvd

SETARGDFIIRDLKLISTKDPS-VIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEeweSEVEKNShqfdiIGPIVVHCNNGIGRTGVYCALHALWQQIT
 .    ...|| .|..  .| .   | . .||.. ||..  |     ||...  ..   |  .|.      .||.||||  |.||||   ||    .|. 
rnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrain...sandkee.....ygpvvvhcsagvGrtGtiialdialeqlk

QEKLVSV
 |. | .
lenkvdi

0036282 (Phosphotyrosine protein) phosphatases II 415-606 1.8e-32 107.8 In-house 1-144 (174) alignment
Range on Protein: 415-606
Range on HMM: 1-144/174.0
GSDYINASYIDGFTRREAFIATQHPLQsttmdYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAvhdtahfgdyevtmesetargdfiirdlklistKD
||||||||..|.. . . .||.|.||.     .|.|.........||||.|||...  .. | |                                  . 
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lr

PSVIRQIRHFHFLHWPEHGQPWSGQtVLQLVSKVEEWESEveknshqfDIIGPIVVHCNNGIGRTGVYCALHALWQQITqEKLVSVYQTAWL
 .  | . ....|.|| || | . . .|..|. |||. ||        |  ||..|||. |.||||. .|.  . ...  |.|| ....   
edlerlgiqylylpwpDhgvpdlsi.llefvkfveealse........dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvre

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 44-185 2.5e-32 106.6 In-house 38-179 (515) alignment
Range on Protein: 44-185
Range on HMM: 38-179/515.0
SQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNR
.|.  |  |||. |.. || .|| | . ...  | |.|| |. .... .||||.|||.  ...||||.....|   |.|.|.  |  . ||. ||| |  
aqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpg

KTENHGPLTITFVQEETFAYYSIRTFEIKPNKDGTHYTQYMH
.. . | . .  |  |. .   .|....  ..|    ||.  
dsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhf

subfamily_PTPN1_pd Subfamily PTPN1 397-595 5e-32 105.8 In-house 41-231 (290) alignment
Range on Protein: 397-595
Range on HMM: 41-231/290.0
ICVIDSSRVRLYprpgEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHD--TAHFG--DYEVT
.   | ||..|     ..  |||||| ..    .  .| || || .|.  .|.|.|.......|||    | ..    .| |  ..  .  .    ..|.
vspydhsrikle....radndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvk

MESETARGDFIIRDLKLISTKDpSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVEKnsHqfdiiGPIVVHCNNGIGRTGVYCALHALWQQI
. ||  .  ...| |.|   |     |.| |||.. ||. | | | .. |... || |  | ...  .     || |.||  ||||.| .| . ..  .|
liseerksyytvrllelenlkt.qetreilhfhyttwpdfgvpespaaflkflfkvresGslssd..v.....GpavihcsaGiGrsGtfclvdtclvli

TQE
 ..
ekk

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 209-319 7e-32 105.6 In-house 171-279 (288) alignment
Range on Protein: 209-319
Range on HMM: 171-279/288.0
EVKPMMVKQFHFTGWPDHGAPEPgfEFPVLDLIMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQY
. . . ..|.....||||| ||   . |.|.|. .        |||..|||||||||.| ||..| .|.... .  .|.....|..|.||. |||.. ||
kkteleitqyqylaWpdhgvPes..kapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqY

IFIHDTLAEYI
.||...|.. |
efiyevllsli

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 214-318 1.1e-31 105.3 In-house 186-291 (319) alignment
Range on Protein: 214-318
Range on HMM: 186-291/319.0
MVKQFHFTGWPDHGAPEPGFefPVLDLIMK--STACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFI
 ..|||| ||||.| |. .   ... |. |         .  ..||||||||||.|..||.| ...|....  .|..||.  .|.|||.|||.  || ||
kitqfhflGwpdvGvpdyps..dlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfi

HDTLAE-Y
. .| | .
ysalleeh

0043147 (Phosphotyrosine protein) phosphatases II 412-603 1.2e-31 105.1 In-house 1-138 (172) alignment
Range on Protein: 412-603
Range on HMM: 1-138/172.0
GEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEkewdkdvfpsylpavhdtahfgdyevtmesetargdfiirdlkliS
|.||||||||||.|.      ||||| ||..|. |.|||....... ||.| ..                                              
gdegsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.............................................l

TKDPSVIRQIRHFHFLHWPEHGQPwSGQTVLQLVSKVEEWESEVEKnshqfdiiGPIVVHCNNGIGRTGVYCALHALWQQITQEKLVSVYQT
.  . . |.. ....| || || | . . .|.... ..|.  . ..        ||..|||  |.||||. .|.. ...... |. |. ...
ydpellerlgiqylylpwpDhgvp.llellleflefidellalspg........gpvlVHCsaGvgRtgtlvaaylmllglsleeavalvre

0041856 (Phosphotyrosine protein) phosphatases II 392-611 1.6e-31 104.7 In-house 5-150 (182) alignment
Range on Protein: 392-611
Range on HMM: 5-150/182.0
RRVPRICVIDSSRvrlyprpgeeGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVfpsylpavhdtahfgdyev
.|.. |  .| ||          ..|||||....|  .   |||||.||.||. |..||........||.| .|  | ...                   
nrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpell...................

tmesetargdfiirdlklistkdpsvIRQIRHFHFLHWPEHGQPWsGQTVLQLVSKVEEweseveknshqfdIIGPIVVHCNNGIGRTGVYCALHALWQQ
                           |.. ....| || || |   ...|... .|.|               ||..|||. |.||||...|.  ....
..........................erlgiqylylpwpDhgvpd.ldelldfieevle.............eggpvlVHCsaGvgRtgtlvaaylmkkl

itqeKlVSVYQTAWLQGHQR
    . ||....  |   .|
....g.vsleeavklvrsrR

subfamily_PTPRN_pd Subfamily PTPRN 35-175 1.8e-31 103.9 In-house 42-182 (297) alignment
Range on Protein: 35-175
Range on HMM: 42-182/297.0
KNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYV-DTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHK
...  |   .....|  ||| ..|..|||||| |. . ....|.||||  . |.   . ||||||||||.|..|||.|.||| . |||..|.. |.| ..
eaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkq

CAMYWPTKNrkTENHGPLTITFVQEETFA-YYSIRTFEIKPNK
|. ||| .   .| ..   . .| |  ..  | .|.| .|  .
ckrywpdeG..sevyhiyevhlvsehiwcddylvrsfylknlq

0051082 (Phosphotyrosine protein) phosphatases II 77-314 3.2e-31 103.3 In-house 3-148 (151) alignment
Range on Protein: 77-314
Range on HMM: 3-148/151.0
SHYINANYVDTYnamnaYIATQGPLAktisDFWRMIWEQNCRVIVMITNIIEKGrhKCAMYWPTKNrktenhgpltitfvqeetfayysirtfeikpnkd
|.|||..||. .     .....||||    ||.....|.....||....  | |  .|. |.|  .                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

gthytqymhgtmfdssastnmlldesldplddevkpMMVKQFHFTGWPDHGAPEPGFEFPVLDLIMKStacvvPGTGPLVVHCSAGVGRSGAFIVIDSMI
                                    . |.......|||.| |.   ..  .  .. .     .. ||..||||||.||.|...... |.
....................................ievlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylml

KRihdngdLDIFNFLAHIRNQRNHLVQEECQYIFIHDT
 .      ....  |...| .| ..|| . |..|..  
lg......vsleealeeyrlkrpgvvqpnqqflfqlfa

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 214-318 4.4e-31 103.4 In-house 150-255 (284) alignment
Range on Protein: 214-318
Range on HMM: 150-255/284.0
MVKQFHFTGWPDHGAPEPGFefPVLDLIMK--STACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFI
 ..|||| ||||.| |. .   ... |. |         .  ..||||||||||.|..||.| ...|....  .|..||.  .|.|||.|||. .|| ||
kirqfhflgwpdvgvpdyps..dlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfi

HDTLAE-Y
. .| | .
ysalleeh

0046846 (Phosphotyrosine protein) phosphatases II 406-599 5.2e-31 103.1 In-house 2-145 (176) alignment
Range on Protein: 406-599
Range on HMM: 2-145/176.0
RLYPRPGEEGSDYINASYIDGFtrreAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHDTAHfgdyevtmesetargdfiir
||...  ....|||||..|.|     ..||||.|| .|..|...|....... .|.|..|.| ..  .| | | ...  .                    
rlrllgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi....................

dlklistkdpsvirqirHFHFLHWPEHGQPWSgQTVLQLVSKVEEWESEvekNshqfdiiGPIVVHCNNGIGRTGVYCALHALWQ--QITQEKLVS
                 ....|.||.|| | . . .|.|.  ..|. .|   .       ||..|||  ||||||...|.  |.   ... |. ..
.................qylhlpwpDhgvpdl.elllellefirealke...g.......gpvlVHCsaGigRtgtlvaayllelekglsveeala

PTPc_DSPc_SM00012 215-317 6.2e-31 102.1 In-house 2-105 (105) alignment
Range on Protein: 215-317
Range on HMM: 2-105/105.0
VKQFHFTGWPDHGAPEPGfeFPVLDLIMKSTACVVPG--TGPLVVHCSAGVGRSGAFIVIDSMIKRIHDN-GDLDIFNFLAHIRNQRNHLVQEECQYIFI
||..|.|||||||.||..   ..|.|. .   .      ..|.||||||||||.| |...| ........ . .|||... ..|.||...||.| ||.|.
vkhyhytgwpdhgvPees..dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfl

HDTLAE
.. |.|
yralle

subfamily_ptpA1_pd Subfamily ptpA1 18-172 1.1e-30 101.7 In-house 16-165 (418) alignment
Range on Protein: 18-172
Range on HMM: 16-165/418.0
HADCDYKFFMEFEGVHEKNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAmNAYIATQGPLAKTISDFWRMIWEQNC
|  | .|   ||  . |        . .|  |  |||..|..  .|.|| |   .. . | ||||||.|     . .|.||||| .||.|||||.||. |
hikcihkikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrc

RVIVMITNIIEKGRHKCAMYWPTKNRkTENhgpLTITFVQEETFAYYSIRTFEIK
|.|||..   |. | ||  ||| .    |.   ..|    .| |  ||.   |. 
riivmlsresencrikcdrywpeqig.geq...fsiygngnevfgtysvelvevi

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 3-182 1.5e-30 101.4 In-house 8-180 (297) alignment
Range on Protein: 3-182
Range on HMM: 8-180/297.0
EPIPYEAFRSHVKH-LHADCdykFFMEFEGVHEKNkRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAmnAYIATQGPL
.|||   | . |..  |.|    |  ||  . | |   .  ...|  |  |.|..|.. || ||| |  ...| .| |.|| .| ...    .|.|| | 
rpiplsdfatlvqknrhtdv...fseeflclpean.iqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPm

AKTISDFWRMIWEQNCRVIVMITNIIEKGRhKCAMYWPTKNRKTenHGPLTITFVQEETFAYYSIRTFEIKPNK-DGTHYTQ
  |. |||.|.....  .|||...  |. . ||| ||. |  .|   | ....    .    .. |..|.. .|   ..  .
katvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt..fGdvsvvllsvsereGfikrelevtkgkakarrvvk

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 9-179 1.2e-29 98.0 In-house 6-171 (439) alignment
Range on Protein: 9-179
Range on HMM: 6-171/439.0
AFRSHVKHLHADCDYKFFMEFEGVHEKNKRLTWVQS--QKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAKTIS
 |. ||..|. . .  |  .|| .   .   . . |   .  .| |||. .|.|.||.||.|  .     ||||||||.. |   . |||||||  .|  
efqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettd

DFWRMIWEQNCRVIVMITNIIEKGRhkcamYWPTKNRKteNHGPLTITFVQEETFAYYSIRTFEIKPNKDGTH
||||...|...  |||.||..|  .     |||...     .| ...   ..  .  | || | .  ..| |.
dfwrlviekktvtivmltnlvesyk.....ywpsdaev..cygdiavrvdrnielpnyvirgfkvfnerdtte

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 39-163 1.4e-29 97.9 In-house 23-147 (297) alignment
Range on Protein: 39-163
Range on HMM: 23-147/297.0
LTWVQSQKPENQMKNRFANVVAYDHSRVVLSltENDQSSHYINANYVDTYN--AMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAM
 ..  ....    |||. ...|.| .|| |        . ||||.||   .  |   || .|||| .|. |||....||. |||||.... | ||.||| 
esfssakrnsslrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcap

YWPTKNRKTENHGPLTITFVQEETFAY
|||  . .  . | . . |. . .  .
ywpsvvqerlkagdvvveflsstsdef

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 213-364 2.3e-29 96.9 In-house 172-318 (515) alignment
Range on Protein: 213-364
Range on HMM: 172-318/515.0
MMVKQFHFTGWPDHGAPEPgfEFPVLDLIMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIH
  | |||||.|||.|.|.      .| || .  |     | ||..|||||||| | .| |||.. ....   .|.|||.  ||..| .||| . || ||.
rtvtqfhfteWPdkGvpkh..tssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiy

DTLAEYIA-CNFVIslPIKALKDHVRMMRmpISIQPPVKSKLDLEYEVLYCSC
... |..   | .|  |.  . ||.. .    | .   .||.  |.. | . |
gavledllwrntli..pvihftdhlqdlh..ssgdgrgrskmtkefqtlkslc

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 214-315 4.1e-29 96.4 In-house 137-236 (239) alignment
Range on Protein: 214-315
Range on HMM: 137-236/239.0
MVKQFHFTGWPDHGAPEpgFEFPVLDLIMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHD
 | |.||| |||.| |.  .   || |  | |   .||. | |.||||||||.|||.|||.|... . .  .||||..  ||..| |.||   ||.||| 
yvyqyhftvwpdkgvpq..yatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihl

TL
..
av

subfamily_CG42327_pd Subfamily CG42327 47-173 4.6e-29 96.1 In-house 26-155 (319) alignment
Range on Protein: 47-173
Range on HMM: 26-155/319.0
PENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYN-AMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNR--
.  . |.|..|||   ..||||    .|....|..|.||  |. | | |||.| .| .. |||||..|||. |||| .|.. |.| ..|| |.|||.   
vtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketld

KTENHGPLTITFVQEETFAYYSIRTFEIKP
 |. .| . .|. . |.   | | |. .| 
ntslyGdilvtlkgrevkdryaistlllkr

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 214-314 4.8e-29 96.2 In-house 138-236 (239) alignment
Range on Protein: 214-314
Range on HMM: 138-236/239.0
MVKQFHFTGWPDHGAPEpgFEFPVLDLIMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHD
 | |.||| |||.| |.  .   || |  | |   .||. | |.||||||||.|||.|||.|... . .  .||||..  ||..| |.||   ||.||| 
yvyqyhftvwpdkgvpq..yatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihl

T
.
a

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 394-602 1.3e-28 94.8 In-house 14-211 (239) alignment
Range on Protein: 394-602
Range on HMM: 14-211/239.0
VPRICVIDSSRVRLYPRPGEEGSDYINASYIDGFT-RREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPavHDTAHFGDYEVT
   |   | ||| |     .  ||||||||.  .    .|.||||  .. .. |.|||.|||    ||||    |  |     | |    |... .  ||
yanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp..dstskycnlrvt

MESETARGDFIIRDLkLISTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVeewesevEKNShqFDIIGPIVVHCNNGIGRTGVYCALHALWQQI
.       |.||| . ..|    .  | . ..||  ||..| |    .|| |  |.        |.|  .    | |.||. |.|||| .  . |. .| 
lrktevfadyiirtf.vmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrki.......tkds..lpgarpwvihcsagvgrtgaflvidamlrqa

TQEKLVSVYQ
 ..| | ...
kkqktvdifn

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 394-602 1.3e-28 94.8 In-house 13-210 (239) alignment
Range on Protein: 394-602
Range on HMM: 13-210/239.0
VPRICVIDSSRVRLYPRPGEEGSDYINASYIDGFT-RREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPavHDTAHFGDYEVT
   |   | ||| |     .  ||||||||.  .    .|.||||  .. .. |.|||.|||    ||||    |  |     | |    |... .  ||
yanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp..dstskycnlrvt

MESETARGDFIIRDLkLISTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVeewesevEKNShqFDIIGPIVVHCNNGIGRTGVYCALHALWQQI
.       |.||| . ..|    .  | . ..||  ||..| |    .|| |  |.        |.|  .    | |.||. |.|||| .  . |. .| 
lrktevfadyiirtf.vmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrki.......tkds..lpgarpwvihcsagvgrtgaflvidamlrqa

TQEKLVSVYQ
 ..| | ...
kkqktvdifn

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 214-359 1.4e-28 94.7 In-house 174-314 (315) alignment
Range on Protein: 214-359
Range on HMM: 174-314/315.0
MVKQFHFTGWPDHGAPEPGFefPVLDLIMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHD
 | ||.||.|||.|...      .| || .  |   . . .|.|||||||||.| .| ||.....|...  .|.|||.  .|..| .||| | .| ||.|
tvtqfqftewPdkGvdkqts..sllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiyd

TLAEYIACNFVIsLPIKALKDHVRMMRmpISIQPPVKSKLDLEYEV
.. |..    .. ...  . ||.. ..   | .   .||.  |.| 
avledllwrntl.ilvihftdhlqdlh..tsvdgsgrskmtkefet

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 22-182 2.4e-28 93.9 In-house 5-159 (267) alignment
Range on Protein: 22-182
Range on HMM: 5-159/267.0
DYKFFMEFEGVHEKNK-RLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDqsshYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVI
. ..  ||| ...  . . |  ||   .|| .||. ... ||..||.|. .|..    |||| ||..|.  ||.|.||.|| .||.||. .| .|.. ||
eceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvi

VMITNIiekGRHKCAMYWPTKNRKTENHGPLTITFVQEETFAYYSIRTFEIKPNKDGTHYTQ
|..|..   .  .  ..|| |  .....  ||. .  |.    | | |.|.| ... .|   
vlltkv...ftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvt

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 396-602 1.4e-27 91.1 In-house 53-206 (392) alignment
Range on Protein: 396-602
Range on HMM: 53-206/392.0
RICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDkdvfpsylpavhdtahfgdyevtmes
 |  .||.||.|        |||.|||||..|   .|.||.| |  ..  |.|||..|||  .|.|.   || |                          
nilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd..........................

etargdfiirdlklistkDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVeewESEVEKNSHqfdiigPIVVHCNNGIGRTGVYCALHALWQQITQE
                       | .  |||  ||... |    ..|... .|   ...  . .|      |...||. |.|||||  .. ..  .  . 
..................kgddartvaqfhftewPdkdvpkhtssllkfikev...kadfGqyth......pliihcsagvgrtgvvisidsvvahakkt

KLVSVYQ
..| |..
rmvdvfn

subfamily_ptpA1_pd Subfamily ptpA1 396-586 2.7e-27 90.5 In-house 55-250 (418) alignment
Range on Protein: 396-586
Range on HMM: 55-250/418.0
RICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRrEAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHD----------TAH
 |  .. .||.|     .|||||||| ||||    . ||.|| ||  |  |.|||.|.. || ||||  | |  .     | |                 
nilpvnhtrvqlkkiqdkegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnev

FGDYEVTMES--ETARGDFIIRDLKLISTKDpsvIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVEKNShqfDIIGPIVVHCNNGIGRTGVYC
|| | | .    .    . | |...|    .    |.| ....  ||.|  |   | . ||.  . . . ..  .|   |   ||.|||. |.|||| .|
fgtysvelveviqdpereiitrnirltfege...trditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipss...drnvpiivhcsagvgrtgtfc

ALH
.  
tav

0051082 (Phosphotyrosine protein) phosphatases II 415-602 4.5e-27 89.9 In-house 2-129 (151) alignment
Range on Protein: 415-602
Range on HMM: 2-129/151.0
GSDYINASYIDGFtrreaFIATQHPLQsttmDYWRMIWQENCRSIVMLLSEKEWDkdVFPSYLPAVHdtahfgdyevtmesetargdfiirdlklistkd
 |||||.||..|.     ......||.    |............||.| ||.|..   .|.|||.                                   
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

psviRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEwesevekN-ShqfdiiGPIVVHCNNGIGRTGVYCALHALWQQITQEKLVSVYQ
    ....|...| ||..| | | ..||........       . .      ||..|||. |.||||. .||  . .... |. .. |.
....ievlhipildwpdpglplsfdavleflellld.......kkn......gpvlvHCsaGkgRTGtlvalylmllgvsleealeeyr

0049260 (Phosphotyrosine protein) phosphatases II 423-602 5.1e-27 89.8 In-house 1-126 (152) alignment
Range on Protein: 423-602
Range on HMM: 1-126/152.0
YIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLpavhdtahfgdyevtmesetargdfiirdlklistkdpsvirqir
.|||. .  .|||||.|.  |. |.|||... ... |||| .. | .|. .. |                                              
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

HFHFLHWPEHGQPWSGQTVLQLVSKVEEWeseVEK--NshqfdiigPIVVHCNNGIGRTGVYCALHALWQQITQEKLVSVYQ
....| || || | . | .|.|.  .|..    ..  .        |..|||  |.||||...|.  ...... |. |. ..
qylhlpwpDhgvpdlsqlllflllfiekl...aldkgg........pvlVHCsaGvgRtgtlvaaylmllgvsleeavalvr

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 213-333 8.7e-27 89.1 In-house 178-301 (325) alignment
Range on Protein: 213-333
Range on HMM: 178-301/325.0
MMVKQFHFTGWPDHGAPE-PGFEFPVLDLIMKSTACVVP---GTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQY
. ||||.. .|.| | .. |    ..|.|. .   .|     ...|..|||||||||.|.|| . |..... ..  .|||.|. ..|..|  .|.   ||
rsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqy

IFIHDTLAEYI-ACNfvISLPIKALK
|.|...|.|.. . |    .|. ...
iliyealveaymsgn..tdvpvssfe

subfamily_PTPN12_pd Subfamily PTPN12 214-321 9.1e-27 88.7 In-house 171-279 (290) alignment
Range on Protein: 214-321
Range on HMM: 171-279/290.0
MVKQFHFTGWPDHGAPEPgfEFPVLDLIMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRI---HDNGDLDIFNFLAHIRNQRNHLVQEECQYIF
.|.|||.| ||||| |.   . ..|.|| .          |||||||||||| |. |.|| . . .   . . .||.|. ....|.||. ||| . || .
kvyqfhYtaWPDhgvPss..aksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyel

IHDTLAEYIAC
.. ..||..  
vykavaelvqk

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 50-181 1.1e-26 88.1 In-house 57-184 (290) alignment
Range on Protein: 50-181
Range on HMM: 57-184/290.0
QMKNRFANVVAYDHSRVVLSlteNDQSSHYINANYVDTYNAMnaYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNRKTENHG
  |||. .||  | .||.|.   . .   |. ||||.  .||  .| |||.|..|. |.|||. ...  .|||. ..||.|. ||. |.| |. ..   |
fkknrykdvvcndktrvilk...dGydGdyvhanyvkGlkam..filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfG

PLTITFVQEETF-AYYSIRTFEIKPNKDGTHYT
 .|..  .|..  |    .|. ..  ..| .. 
eitvlcseeddkdaniikktlsvrdkdsGkehk

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 401-600 1.2e-26 88.1 In-house 69-251 (290) alignment
Range on Protein: 401-600
Range on HMM: 69-251/290.0
DSSRVRLypRPGEEGsDYINASYIDGFtrREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHD-TAHFGDYEVTMESETAR
| .|| |  . | .| ||. | |..|   .  || || .|..|..|.|||. ||.   ||||    |  |     | |  .  .  ||.. |.   |. .
dktrvil..kdGydG.dyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddk

GDFIIRDLKLISTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEeweseveKNShqfdiiGPIVVHCNNGIGRTGVYCALHALWQQITQEKLVS
 . ||. .  .  ||     ...|..   ||..  . |  ..|...  .        | |      ||.||||  |||||| . |. .  | ... | . 
daniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilr.......kas......GpvvvhcsaGiGrtGtfvaievglqilldGkeld

V
.
l

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 208-320 1.7e-26 88.0 In-house 165-277 (281) alignment
Range on Protein: 208-320
Range on HMM: 165-277/281.0
DEVKPMMVKQFHFTGWPDHGAPEPGFEFpvLDLIMKSTACVVPGT-GPLVVHCSAGVGRSGAFIVIDSMIKRIHDN-GDLDIFNFLAHIRNQRNHLVQEE
.. ..  |.|...| |||||.|.   |.  |.   . . .  . |  |||.||||||||.|..| .| ..|.....  .||. . .|..|..|| .||  
esgetreveqlaytaWPdhGvPattkel..lefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtv

CQYIFIHDTLAEYIA
 || |.. .. ... 
vqyefvykavldald

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 48-159 2.2e-26 87.1 In-house 51-160 (310) alignment
Range on Protein: 48-159
Range on HMM: 51-160/310.0
ENQMKNRFANVVAYDHSRVVLSLTEnDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNrKTEN
..  |||...||  | ||| | .    .   || |||| |    ...| .|||| .|| ||||||... .  |... .. |.|| ||  |||.    || 
kymhknrysdvvcldtsrvklkidk.sryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslg.vtet

HGPLTITFVQEE
.| . .| . | 
ygcirvtnlses

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 248-319 6.3e-26 86.0 In-house 188-259 (267) alignment
Range on Protein: 248-319
Range on HMM: 188-259/267.0
VVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHDTLAEYI
.  |  ||||.||.||||||.|.||||...|.  .| .|||.|| .||.||  ||.   .||.||..|||| 
lengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeya

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 213-321 1.2e-25 85.3 In-house 177-286 (297) alignment
Range on Protein: 213-321
Range on HMM: 177-286/297.0
MMVKQFHFTGWPDHGAPEPGFEFPVLDLIMKSTACVVP-GTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFI
 .|||..|. |||.  ..      .|.||            |||.|||.||||| | .. |||.. ..... ..|||... ..|..| .||| . || |.
rvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfv

HDTLAEYIAC
. .. |.. .
yvavlealls

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 210-322 4.7e-25 83.1 In-house 170-281 (287) alignment
Range on Protein: 210-322
Range on HMM: 170-281/287.0
VKPMMVKQFHFTGWPDHG-APEPGFEFPVLDLIMKSTacVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQY
 .. .|||...| |...|  .||   . |..  .|.     .| ...|||||..||||. |. ..  |.. . .| .|.|. | . | |. . ||   ||
gdkqqvkqyqitnWdstgkvtepqtillvieemyktq..rkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqy

IFIHDTLAEYIACN
.|| | . ||. . 
kfindivleyldsf

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 45-142 5.1e-25 82.7 In-house 33-131 (281) alignment
Range on Protein: 45-142
Range on HMM: 33-131/281.0
QKPENQMKNRFANVVAYDHSRVVLSL-TENDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKN
..| |. |||..|. . | ||| | .   | .|. || |||. .      || ||||  .| .|||||||..|   |||. ...|  | ||| |.| . 
nqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprna

0044763 (Phosphotyrosine protein) phosphatases II 400-591 5.7e-25 83.4 In-house 2-136 (178) alignment
Range on Protein: 400-591
Range on HMM: 2-136/178.0
IDSSRVRLYPRPGEEGSDYINASYIDGFtrreaFIATQHPLqsttMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHDtahfgdyevtmesetar
.| .|| |....|.|.|||||||.|...     ......|      |............||.| .|.|. .   . | |  ..                 
ldrtrvllsnleglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag.................

gdfiirdlklistkdpsvirqiRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESevEKNshqfdiiGPIVVHCNNGIGRTGVYCALHALWQQ
                       .......| || | . . .|..|  .||. .  ||.       ||..|||. |.||.|. .|.  ....
......................iqylhipipDhgvpdllehflefvefieeald..ekg.......gpvlVHCsaGvgRsgtlvaaylmkkl

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 214-322 1e-24 82.1 In-house 176-282 (315) alignment
Range on Protein: 214-322
Range on HMM: 176-282/315.0
MVKQFHFTGWPDHGAPEpgFEFPVLDLIMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHD
 | |.|.| ||| | |.  .  |...|| .         |..||||||||||.|.|| .|....... .  .|..||.  .|..| ..||   || ||.|
evvqlhytswpdmgvpk..ytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiyd

TLAEYIACN
.| | . | 
alletfvcg

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 213-343 2.1e-24 80.7 In-house 89-217 (440) alignment
Range on Protein: 213-343
Range on HMM: 89-217/440.0
MMVKQFHFTGWPDHGAPEpgFEFPVLDLIMKSTA-CVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFI
  .||.|. ||||.| |.  |  ||| .|          | |||.||||||.||.|  |..||...  . . ..|||.|.  .||.| ..||   || |.
rtlkqyhyqgwpdkgvpk..fagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

HDTLAEYIACNFVISLPiKALKDHVRMMRMPI
|... | . |  .. |    . ..|  ...| 
heavlegllcgdtlile.dditerveqiqwpn

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 394-593 2.3e-24 80.5 In-house 43-228 (281) alignment
Range on Protein: 394-593
Range on HMM: 43-228/281.0
VPRICVIDSSRVRLYP-RPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPA-VHDTAHFGDYEV
   | ..| |||.|    | .. .||| | ||     .  .| || | . |  |.||||||||  .||||    | ...    |.|   |   .|  . |
ylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsv

TMESETARGDFIIRDLKLISTKDpsvIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEwesevekNSHqfdiigPIVVHCNNGIGRTGVYCALHALWQQ
. |  |    ..   |.|    .    | | |. .  ||.   | | . .|... |.          |       | |.||  |.||.|   |.    | 
syedstvnkslvttrlnlsyege...trlithwlwkewpdwqvpessevmlkilrkira.......rst......ppvihcsagvgrsgtlmaveialqs

IT
| 
ih

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 415-612 2.5e-24 80.7 In-house 56-239 (267) alignment
Range on Protein: 415-612
Range on HMM: 56-239/267.0
GSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEkeWDKDVFPSYLPAVHDTAHFGDYEVTMESETARGDFIIRDLKLIStKD
  .||||||..|. ...|||.|| ||. |  |.. .| ....  ||.|        ..   . | . .. .. |  |    |    |. |  |.|   |.
eeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkv..ftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkf.kn

PSViRQIRHFHFLHWPEHGQ--PWSgQTVLQLVSKveeweSEVEKNSHqfdiigPIVVHCNNGIGRTGVYCALHALWQQITQEKLVSVYQTAWLQGHQRP
 |  ...  ... .|    .  |.  . .. ...|      ..|. ..      |.||.|..|.||.| .  ...  ... .|  . ...      .||.
esa.hnvtlyyykkwnintnnkpyl.kplfgilak.....nqlengnr......PlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqri





subfamily_PTPN13_pd Subfamily PTPN13 213-315 4.7e-24 80.1 In-house 166-265 (273) alignment
Range on Protein: 213-315
Range on HMM: 166-265/273.0
MMVKQFHFTGWPDHGAPEPGFEfpVLDLIMKSTAcVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIH
  | ...|. ||||| |    |  .| ....    .   .||.|||||||.||||..|.|| ..  |. . ..|. . . ..|.||. .|| . ||||..
revahlnfvkwPdhgvPssaae..llqfvaevrr.lqtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvy

DTL
 ..
kai

subfamily_CG42327_pd Subfamily CG42327 400-548 9.9e-24 78.6 In-house 40-190 (319) alignment
Range on Protein: 400-548
Range on HMM: 40-190/319.0
IDSSRVRLYPRPGEEGSDYINASYIDGFTRR-EAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPA---VHDTAHFGDYEVTMES
.  .|| |   . .. . |..|||. |.      .||.| .|.... |.||..|. . | || | .  |   .| . |||.     .|  .||. ||.  
lPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkg

ETARGDFIIRDLkLISTKDPSVIRQIRHFHFlHWPEHGQPWSGQTVLQLVSKV
  ..  ..|  | |.   | .  |.. |. . .|.| . | . .... .. .|
revkdryaistl.llkrvdkeesrelthywy.kwleaevPaeeaaliamllev

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 24-149 1.8e-23 78.0 In-house 17-139 (307) alignment
Range on Protein: 24-149
Range on HMM: 17-139/307.0
KFFMEFEGVHEKNKRLTWVQSQKpENQMKNRFANVVAYDHSRVVLSLteNDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMI
..  ||. . .|.     |.. .  |. |||. .| . |..|.|. .  .  .| || |||. .    . .|..|||| .|. .|| |. ...   ..|.
alvdefrvlakktpegvtveafs.antdknryqdvkcqdkgrivvkf..dglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesviml

TNIIEKGRHKCAMYWPTKNRKTENHG
 ..|| .. ||  ||| .. ..  .|
ckvielakikceqywpleegqklvfg

subfamily_PTPN9_pd Subfamily PTPN9 214-319 2.7e-23 77.4 In-house 174-290 (297) alignment
Range on Protein: 214-319
Range on HMM: 174-290/297.0
MVKQFHFTGWPDHGAPEPGFEF-PVLDLIMKSTACVVP----------GTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLV
 |  | |..|||.| |. . ..  ||. . .  |..|              |.|||||||.||.|.|| .|  ..|... | .|... . ..|.|| . .
kvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsi

QEECQYIFIHDTLAEYI
| . || | . .. || 
qtpeqyefcylavleya

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 49-320 3.8e-23 76.4 In-house 48-345 (349) alignment
Range on Protein: 49-320
Range on HMM: 48-345/349.0
NQMKNRFANVVAYDHSRVVLSL------------TEND--QSSHYINANYVD--TYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRH
   |||. ... |.||||.|              .| |  .  .||||||.    ... . ||||| ||  |. ||...|  .. .... ...  |.. .
lfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsle

KCAMYWPTKNRKtENHGPLTITFVQEETFAYYSIRTFEIKPNKDGTHY-TQYmhGTMFDSSASTNMLLdesldpldDEVKPMMVKQFHFTGWPDHGAPEP
|| .||   . . . .  |  .. .       | | .. | ...  .   .       |    ...||        .. || .. |. .  |.| .    
kcdiywqelsys.nitvklqnsslyianvqGnslrvstvkdtdndndnnkkn..Cdlpddddddaill........avekPyellqlqvknwldlsllln

GFE--------FPVLDLIMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIK----RIHDNGDLD--------IFNFLAHIRNQRNHLVQEECQYIFI
             ..|  .         . .|.|||||| ||.| .. .|...       ..   ..        |.  . ..| ||  .||.  |.|.|
PisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiai

HDTLAEYIA
...| .|.|
yealLkyfa

subfamily_egg_pd Subfamily egg 33-155 4.5e-23 76.4 In-house 24-146 (307) alignment
Range on Protein: 33-155
Range on HMM: 24-146/307.0
HEKNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKgrH
.|  .. .  .. . .|. | |   |   | ||| | | .   .  .| ||.|.    .| .| .| ||  |  |||||....... |||.|   |   .
eesvdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..e

KCAMYWPTKNRKTENH--GPLTITF
.|  |||  . ..     | | |. 
rceyywpkaesdslvtvpGslrien

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 419-600 5e-23 76.3 In-house 78-249 (301) alignment
Range on Protein: 419-600
Range on HMM: 78-249/301.0
INASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAV-HDTAHFGDYEVTMESET--ARGDFIIRDLKLISTKDP
| | .|.   . . ||||| ||..|. |.| |. | .   ||||  . |  ...  .|||   ... . | ........    . . . | |..  . . 
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

SVIRQIRHFHFLHWPEHGQPWSGQTVLQLVskveewesEVEKNSHQfdiigPIVVHCNNGIGRTGVYCALHALWQQITQEKLVSV
   | . |. . .|...| | |   . .|.        |. |.|..     ||||||..||||.  . . . | ...  .. . .
fatrtvthyqysewtdrgvPkshaelfdlm........elvkksek.....PivvhcsaGiGrsvafigteylareveadptiel

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 394-597 7.5e-23 75.8 In-house 39-260 (297) alignment
Range on Protein: 394-597
Range on HMM: 39-260/297.0
VPRICVIDSSRVRLypRPGEEGSDYINASYIDgFTRRE---AFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVH-DTAHFGDY
   |   |..||.|  . .  ..||||| |.  |   |    .| .| ||..|  |.|....... | |||.   .|  .|    | | |  .  . ||.
yrdilatddtrvkl..lrviterdyinadyvv.fpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdv

EVTMESETARG--DFIIRDLKLISTkdpSVIRQIRHFHFLHWPEHGQPWSGQTVLQ--------------LVSKVEEWES----EVEKNSHQFDIIGPIV
 |   |.|.      |. .|.||     |  |..||  || ||.|| |   . . .              ... || . .    ..|    .     ...
vveflsstsdefdrviltelqliyr...sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraemprnayll

VHCNNGIGRTGVYCALHALWQQITQEKL
|||  |.||.||    ... ... ....
vhcsaGvGrsGvvvlsdvilaklrkkri

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 211-320 1.4e-22 74.9 In-house 176-284 (290) alignment
Range on Protein: 211-320
Range on HMM: 176-284/290.0
KPMMVKQFHFTGWPDHG-APEPGFEFPVLDLIMKSTacVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYI
.. .|.|...| |...|  ..|     |.  ..|      .| ...|||||..||||. |....  |.. . .|  |.|. | . | |.  .|| . || 
akqsvtqyqitnwdstgkvtnpqtillvieemyktq..rkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyq

FIHDTLAEYIA
.|.. . .|. 
gifqivltyld

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 431-586 1.9e-22 74.4 In-house 5-156 (199) alignment
Range on Protein: 431-586
Range on HMM: 5-156/199.0
EAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVH-DTAHFGDYEVTMESETARGDFIIRDLKLIS-TKDPSVIRQIRHFHFLH
  .|||||||. |  |.|.|.|.     |||.  ..   .  .| | |...  |...|   || .. |.. |. |  | | . |  |   |.| |. |  
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPEHGQPWSGQTVLQLVSkveewESEVEKNSHQfDIIGPIVVHCNNGIGRTGVYCALH
| |.  |     |  .|.       || |.  | .   |..||| .| | |||. || 
wkekttpnvalfvgfvva.....srevskkyeq.ekdapvivhcsdgqgftgvfvald

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 432-586 1.9e-22 74.5 In-house 5-155 (198) alignment
Range on Protein: 432-586
Range on HMM: 5-155/198.0
AFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVH-DTAHFGDYEVTMESETARGDFIIRDLKLIS-TKDPSVIRQIRHFHFLHW
 .|||||||. |  |.|.|.|.     |||.  ..   .  .| | |...  |...|   || .. |.. |. |  | | . |  |   |.| |. |  |
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PEHGQPWSGQTVLQLVSkveewESEVEKNSHQfDIIGPIVVHCNNGIGRTGVYCALH
 |.  |     |  .|.       || |.  | .   |..||| .| | |||. || 
kekttpnvalfvgfvva.....srevskkyeq.ekdapvivhcsdgqgftgvfvald

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 215-320 5.5e-22 73.0 In-house 154-265 (270) alignment
Range on Protein: 215-320
Range on HMM: 154-265/270.0
VKQFHFTGWPDHGAPEPGF----EFPVLDLIMKSTACVV--PGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQY
.  |... |||||.|.          .| .. .  .       ..||.|||||||||.| .|..| ... .. .. .|. . ....|..|  |||   ||
lvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqy

IFIHDTLAEYIA
 |.. ...||. 
eflykavveyae

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 45-145 7.8e-22 72.4 In-house 44-141 (305) alignment
Range on Protein: 45-145
Range on HMM: 44-141/305.0
QKPENQMKNRFANVVAYDHSRVVLsltENDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNRK
.. ... |||. .|   |. || |   |.    .|| |||| |    . .| || || || .||| | ....   | |. |..||| .||. |...|...
keaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkd

T
.
v

subfamily_PTPN14_pd Subfamily PTPN14 215-319 9.1e-22 72.4 In-house 185-296 (300) alignment
Range on Protein: 215-319
Range on HMM: 185-296/300.0
VKQFHFTGWPDHGAPEPGFEFP----VLD-LIMKSTACV--VPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQ
|  . .| ||||| ||   .|      .. .  |..  |       |..|||||||||.|  |. | .|. .. | ..|| . ||..|.|| .|||  .|
vwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaq

YIFIHDTLAEYI
| |....| .|.
YkfvYkvlikyl

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 209-320 1.7e-21 71.2 In-house 170-280 (439) alignment
Range on Protein: 209-320
Range on HMM: 170-280/439.0
EVKPMMVKQFHFTGWPDHGAPEPGfeFPVLDLIM-KSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQ
  |   | |||.. |||.  |       |||..    .|     .||.||||||||||.|. | .|  ..... .  .||   .  .|.||...||. ||
tekertvlqfhyiawpdknvpaqa..shvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcq

YIFIHDTLAEYIA
|.||.... | | 
yvfiynavlediv

0048076 (Phosphotyrosine protein) phosphatases II 212-317 4.9e-21 70.4 In-house 44-141 (145) alignment
Range on Protein: 212-317
Range on HMM: 44-141/145.0
PMMVKQFHFTGWPDHGAPEP-GFEFPVLDLIMKSTACvvpGtGPLVVHCSAGVGRSGAFIVIDSMIKrihdnGDLDIFNFLAHIRNQRNHLVQEECQYIF
  .. |.....|||||.|.   .   .|..| .  .    | || .|||||||||.|...... |..      ...... |...|.|| . |. . |..|
erlgiqylylpwpDhgvpdllellleflefieealke...g.gpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgqlrf

IHDTLAE
... . |
lyefele

0048179 (Phosphotyrosine protein) phosphatases II 208-313 5.9e-21 70.1 In-house 42-139 (144) alignment
Range on Protein: 208-313
Range on HMM: 42-139/144.0
DEVKPMMVKQFHFTGWPDHGAPEP-GFEFPVLDLIMKSTAcvvpGTGPLVVHCSAGVGRSGAFIVIDSMIkrihdN-GdLDIFNFLAHIRNQRNHLVQEE
 |    .. |.....|||||.|.   .   .|..| .  .      || .|||||||||.|...... |.       | |.... ||..|..| . |. .
pefleregiqylhlpwpDhgvpdllellleflefieeale....eggpvlVHCsaGvgRtgtlvaaylmk.....klg.lsleealalvrsrrpgavpnp

CQYIFIHD
 |..|...
gqlrfLle

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 99-311 6.6e-21 69.0 In-house 98-280 (302) alignment
Range on Protein: 99-311
Range on HMM: 98-280/302.0
GPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNRKtenhgpltitfvqEETFAYYSIRTFEIKPNKDgtHYTQYMHGTMFDSSASTNML
 |  .|.  .| .| . |  ..| .....|.. .||| |. .| ..             | .|  |...| ..| . .  ..|   . ...      .  
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvgg.............elkfgrytvktvsvktdle..eftdkksfklytveiknekk

LDEsldplddevKPMMVKQFHFTGWPDHGAPEPGfeFPVLDLIMkstACVVPGTgPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQR
 ..         ... |. ..|..|||||||.     . ||..     |    .  ..|||||||||.|... |   |.    .   |. . .  .|. |
kkk.........vkktvdilafsawpdhGapkea..ytaldilk...fcesykk.nvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcr

NHLVQEECQYIFI
   ||.| | |..
yGavqdeqqliyl

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 397-595 8e-21 69.1 In-house 57-249 (305) alignment
Range on Protein: 397-595
Range on HMM: 57-249/305.0
ICVIDSSRVRLyprPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAV-HDTAHFG--DYEVTM
.  .|  ||.|    |    .|| | |.   |  . || || ||. |  |.| | .|..  .| ||   .|        |...  .|. .|   .  ...
vgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisv

ESETA-------RGDFIIRDLKLISTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEeweseVEKnshqfdiiGPIVVHCNNGIGRTGVYCALH
  |..         .  ... .|.     .  |.. |.|.  ||. | | . ...|.|. |       . |        |||||||  ||||||    | 
kfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekar.....psk........gpivvhcsagigrtgsvvmle

ALWQQITQE
 . .|. . 
yildqllag

subfamily_egg_pd Subfamily egg 393-585 9.7e-21 68.7 In-house 45-221 (307) alignment
Range on Protein: 393-585
Range on HMM: 45-221/307.0
RVPRICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWdkDVFPSYLPA-VHDTAHF--GDY
| .|.   |||||.|  | |    |.| | ...|    . || .| ||. |  |.|||..||... |||| | ||   .  . | |    |.. .  | .
rskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGsl

EVTMESETARGD--FIIRDLKLISTKdpsvirqiR-HFHFLHWpehgqpwsgQTVLQLVSKVeEWESEVEKNSHQfdIIGPIVVHCNNGIGRTGVYCAL
...      . |  | .  |||. ..        .   .  ||         |  .. .|.|  .  .| .   .  .  |.||.. .|. ....  |.
rienlkvdskadplfrvtklklvGgd........deerflehw.........qgdvnnssdv.ysplrvlrklrn..lskpvvvqdilGvskaatlvai

subfamily_PTPN3_pd Subfamily PTPN3 214-316 1.9e-20 67.9 In-house 172-272 (280) alignment
Range on Protein: 214-316
Range on HMM: 172-272/280.0
MVKQFHFTGWPDHGAPEPGFEFpvLDLIMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHD
.. |. .. ||||| |.   .|  |... .  ..    . |.|||||||.||.| .|...  .  |  . .. . . . ..|.||  ||| . || |. .
kilqlqylaWpdhgvPddsadf..lefvervrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCe

TLA
.. 
ail

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 397-595 2.3e-20 67.4 In-house 61-253 (310) alignment
Range on Protein: 397-595
Range on HMM: 61-253/310.0
ICVIDSSRVRLYPRPGeEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHDTAHFGDYEVTMESE
. . |.|||.|         ||| | |.     |..|| .| ||| | .|.||||.|| . ||..|    |  .    .| |..  |  .|   ||  ||
vvcldtsrvklkidks.ryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlse

TArGDFIIRDLKLISTK-------DPSVIRQIRhFHFLHWPEhgqpWSGQTVLQlvskveEWESEVEKNSHQFDIIGPIVVHCNNGIGRTGVYCALHALW
..  .| | .| .           .|. ....|   ...||.    |  . | .      |    | .        || ||||  |..|..| .||.  .
ss.eefeicnlavtfvpdnvpvdeqpanlkelr.vslikwpn....wpdrgvpd......ekchtvpqrllaqvrhgpcvvhcsagkdrlyvvvalklki

QQITQE
... . 
dkldrg

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 399-588 2.8e-20 67.5 In-house 52-232 (307) alignment
Range on Protein: 399-588
Range on HMM: 52-232/307.0
VIDSSRVRLYpRPGeEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHD-TAHFGDYEVTMESET
..| .|. .   .|   |||| | |.   ..   ||..| ||..|  ..| |. ||.  |..||    |  |     | |...  .  ||.   |.  . 
cqdkgrivvk.fdg.lasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvan

ARGDFIIRDLKLISTKDP-----SVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEwesevEKNshqfdiigPIVVHCNNGIGRTGVYCALHAL
   . .  | .||   .      .  | |.|. .  ||..| |    | . |.. |.      ..|        |.||||  |.||.|   |.  .
lgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry.....dtn........pvvvhcsaGvGrsGtivaislv

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 49-142 3.2e-20 67.0 In-house 55-146 (305) alignment
Range on Protein: 49-142
Range on HMM: 55-146/305.0
NQMKNRFANVVAYDHSRVVLSlteNDQSSHYINANYVDTYNA-MNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKN
.. |||...| . |.| | |.   . . |.|| ||||       . .|..|||| .|| .|| |. ...   |||. . .| |. ||| |||. .
aitknryqdvpcqdqsavkld...kpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaq

PTPc_DSPc_SM00012 520-611 4.6e-20 67.1 In-house 1-86 (105) alignment
Range on Protein: 520-611
Range on HMM: 1-86/105.0
QIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVEKnshqfdiIGPIVVHCNNGIGRTGVYCALHALWQQITQE-KLVSVYQTAWLQGHQR
...|.|.. ||.|| | ... .|.|. .|...... |.        .|.|||| .|.||||...||  |.||...| | |...|. .   .||
tvkhyhytgwpdhgvPeesdsilellravkknknkses.......skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqR

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 214-322 8.5e-20 65.7 In-house 187-290 (305) alignment
Range on Protein: 214-322
Range on HMM: 187-290/305.0
MVKQFHFTGWPDHGAPEpgFEFPVLDLIMKSTacvvPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLD-IFNFLAHIRNQRNHLVQEECQYIFIH
 |...|.  ||| | |    .  .|.|. |.     |  ||.|||||||.||.|. .... .....     ..     | .||.|||  .| . ||.|.|
kvthyhwidwpdrgvpa..adlailellekar....pskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvh

DTLAEYIACN
. . .|.  .
qvilnyfrkk

subfamily_PTPRN_pd Subfamily PTPRN 214-319 9.3e-20 65.5 In-house 188-292 (297) alignment
Range on Protein: 214-319
Range on HMM: 188-292/297.0
MVKQFHFTGWPDHGAPEPgfEFPVLDLIMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHD-NGDLDIFNFLAHIRNQRNHLVQEECQYIFIH
 | ||||  ||..|.|      ..|..  |   .    . |.|||||.|.||.|..|.|| ...|.     ..||   | |.|.||..||. . |. |. 
tvtqfhflswpeegvPas..aksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefal

DTLAEYI
 ..|| .
tavaeev

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 49-185 3.2e-19 64.0 In-house 35-170 (285) alignment
Range on Protein: 49-185
Range on HMM: 35-170/285.0
NQMKNRFANVVAYDHSRVVLSLTENDqsshYINANYVDTY-NAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNRKTEN
|   ||.|.| . . .||||   . |    || |...    .  ..||.||||| .|.||||.||....   ..|.  ..| |  |||.|.| |  .  .
npdlnryadvrcieetrvvlknhdrd....yihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvk

HGPLTI--TFVQEETFAYYSIRTFEIKPNKDGTHYTQYMH
 |   |  | ..||. |   . .. .   .| .    || 
fgkyeitlteckeeaiagtilnaltvintedasseplymn

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 213-322 6.8e-19 62.7 In-house 168-280 (287) alignment
Range on Protein: 213-322
Range on HMM: 168-280/287.0
MMVKQFHFTGWPDHGAPEP--GFEFPVLDL-IMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYI
 .|||...  |||....    |.   |||       |    ..||||||...|.|||| .. .  ...|  | | .|. . ....|..|. |||   |. 
rvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlr

FIHDTLAEYIACN
.. ..|. |   |
llyealvtyyktn

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 425-608 7.4e-19 62.4 In-house 230-414 (440) alignment
Range on Protein: 425-608
Range on HMM: 230-414/440.0
DGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLlsEKEWDKdVFPSYLPAVHDTAHFGDYEVTMESETARGDFIIRDLKLISTKDpsvIRQIRHF
.|.....|||||| ||.|| .|.||.. . .  .|.||  ..  ||     | |    .  || . |            .| |.|   ..   . .|| |
egyskknafiatqmpldstvldfwrlvhdyristiiml..nqlndk.tcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkykee...vheirqf

HFLHWPEHGQPWS-------GQTVLQLVSKVEEWESEVEKNSHQFDIIGPIVVHCNNGIGRTGVYCALHALWQQITQEKLVSVYQTAWLQG
    ||   |           ..||||.  ..  | .   .  .     ||.|||  ||  .||.|..    .|. ..  . |.|   |  
evqtwptwiqsdgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllr

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 214-319 7.9e-19 62.8 In-house 177-277 (307) alignment
Range on Protein: 214-319
Range on HMM: 177-277/307.0
MVKQFHFTGWPDHGAPEpgFEFPVLDLImkstACVVPGTGPLVVHCSAGVGRSGAFIVIDSMI-KRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIH
 .... .. |||.|.|.   ..  ..|.      |   | |.||||||||||||. . |  .  | |      |. ...  .|.||.. .|.| ||...|
tiqhlqwenwpdrgvpq..inltainll....eavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylh

DTLAEYI
  | || 
rvlleyf

subfamily_PTPN23_pd Subfamily PTPN23 213-315 2.5e-18 60.9 In-house 171-276 (288) alignment
Range on Protein: 213-315
Range on HMM: 171-276/288.0
MMVKQFHFTGWPDHGAPE-PGFEFPVLDLIMK-STACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIH-DNGDLDIFNFLAHIRNQRNHLVQEECQYI
 .|.  ..| ||..|.|. |.  . .|| . .  .|   .   ||||||||||||.|.| .. . .. .. .|| ||| . . ..|.|| . |||. |. 
ksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlk

FIHDTL
|  .  
fsyeav

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 401-596 2.1e-17 57.7 In-house 68-252 (305) alignment
Range on Protein: 401-596
Range on HMM: 68-252/305.0
DSSRVRLYpRPGeeGSDYINASYIDG-FTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHDTAHFGDYEVTMES----
| | |.|  .|    |||| | |.   .     ||..| ||. |  ..| |. |..   ||||    |  |     | || .   .     . .|     
dqsavkld.kps..psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgs

ETARGDFIIRDLKLISTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEweSEVeknshqfdiigPIVVHCNNGIGRTGVYCALHALWQQITQE
     |  |.   |  |   .    .||... .||. | |    | |.|.| .    |.|           ||||||  ||||||   |.  . ..|...
kpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairg..skv...........pivvhcsagigrtgtivaieyilekiaen

K
|
k

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 396-585 2.2e-17 58.0 In-house 51-224 (288) alignment
Range on Protein: 396-585
Range on HMM: 51-224/288.0
RICVIDSSRVRLYprpgEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVH-DTAHFGDYEVTME
..   | .||.|     ..   ||.|  .     .. .| .| ||..|   .|.|. ... . ||||    |  |.    |.| .  ..|..| .   . 
nlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvk

SETARGDFIIRdLKLISTKDPSVIRQ-IRHFHFLHWPEHGQPWSGQTVLQLVSKVeeweseveKNSHQfdiigPIVVHCNNGIGRTGVYCAL
 . |  | ... . |.  . .   .. ... |.|.|...| | . .. |.|.  .        |. ..     |||||...|.||||     
kkradidklvk.vsllriskegeekvivkilhlleWdddgvPenylsplrllevl........kslqk.....PivvhssaGvGrtgtlili

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 212-319 2.4e-17 57.5 In-house 187-289 (305) alignment
Range on Protein: 212-319
Range on HMM: 187-289/305.0
PMMVKQFHFTGWPDHGAPEpgFEFPVLDLImkstACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLD-IFNFLAHIRNQRNHLVQEECQYIF
 | |.....| ||| | |     .  |.|.    ...     |.|||||||.||.|. . |. ....| .| .   . ...  .|.|| . .|.. ||.|
kmsvrhlqwtewpdrgvpp..ckltslell....sairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylf

IHDTLAEYI
||  . .|.
ihrvmlnyf

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 255-318 1.2e-16 54.8 In-house 1-64 (69) alignment
Range on Protein: 255-318
Range on HMM: 1-64/69.0
LVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHDTLAEY
.|||||.| ||.|.|| |   . ||  .  .|||| . ..|  |  .| .| .||||||.|.| 
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvea

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 3-99 1.8e-16 54.1 In-house 3-95 (95) alignment
Range on Protein: 3-99
Range on HMM: 3-95/95.0
EPIPYEAFRSHVKHLHADCDYKFFMEFEGVHEKNKRLTWVQSqKPENQMKNRFANVVAYDHSRVVLSlTEndQSSHYINANYVDTYNAMNAYIATQG
 ||    | |||  .|.. | .|  ||  .         | |    |  |||| |.. || .||||. |   . | |||| .|| |   |.|||.||
kpihvsvfhshvlemhsnsdqefdnefksismtsgapytvgs.seanipknrflnifpydatrvvlt.tk..rdsdyinacfvdgyarkncyiaaqg

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 207-325 1.8e-16 54.9 In-house 161-276 (285) alignment
Range on Protein: 207-325
Range on HMM: 161-276/285.0
DDEVKPMMVKQFHFTGWPDHGAPEPGfeFPVLDLiMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEEC
|   .|. ... .   |||. |||     |...|  |    | |   |..|||||||||. .|. ||    || .| ...... .  .|  | . ||   
dasseplymnhvqvpwwpdqlapeda..rpmiel.ykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshm

QYIFIHDTLAEYIACNFVI
|..|..  | ||.  . |.
qflflyvvlmeyfigegvv

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 397-585 1.8e-16 55.0 In-house 44-223 (285) alignment
Range on Protein: 397-585
Range on HMM: 44-223/285.0
ICVIDSSRVRLYprpgEEGSDYINASYIDGFTR-REAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPA-VHDTAHFGDYEVTME
. .|. .|| |     .   ||| ||..    . . ..|.|| ||  |  |.|.||.||.   ..|| .  |   .    | |  . .  .|| ||.|. 
vrcieetrvvlk....nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlt

--SETARGDFIIRDLKLISTKDPSV-IRQIRHFHFLHWPEHGQPWSGQTVLQLVSkveeWESEVEKNSHqfdiigPIVVHCNNGIGRTGVYCAL
   | |    |.  | .| |.| |     . | .   ||..  |   . ...|      |  .|. . .      ||.|||. |.|||  .  .
eckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielyk....wvkkvnpkek......picvhcsagvgrtatfvgi

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 45-184 3.7e-16 53.5 In-house 92-224 (244) alignment
Range on Protein: 45-184
Range on HMM: 92-224/244.0
QKPENQMKNRFANVVAYDHSRVVLSltENDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRhkcamYWPTKNRK
 .|.|  ||| .  . .| .|| ||  .   .  |||| .|        || || ||| |  |||.|. |.   |.|..  . |.       |||  .  
fnpnnswknregaglpfdfnrvpls..kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede.....ywpdsepl

TENHGPLTITFVQEETFAYYSIRTFEIKPNKDGTHYTQYM
      .|.|. . . |       .||. . . .| .  |
ewyeeditvtltdrdefknikasnleiesdmneshqaltm

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 391-586 4.6e-16 53.4 In-house 46-230 (312) alignment
Range on Protein: 391-586
Range on HMM: 46-230/312.0
LRRVPRICVIDSSRVRLyprPGEEgSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHDTAHFGDYE
| | | | . |  |  |    |.|   || | ..   |. | |..|| ||..|.  .|..     . ||..| .  |   .    |.  .    .. |. 
lnrypniqcwdrgrftl...agde.nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhr

VTMESETA------RGDFII-RDLKLIsTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVeewesevEKNSHqfdiigPIVVHCNNGIGRTGVYC
|  |. |         | |  | ||..  |      .. |. .  ||.|| | | .| |.|.| |        |. .      |.. ||  |.||||  .
vyteycteieiggkskdkithrvlkvv.vkatgqesklnhyqwaswpdhgmpdscdtalrllsav.......kkdkk......pviahcsagvgrtgtla

ALH
 . 
lie

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 256-318 9.6e-16 51.9 In-house 1-63 (69) alignment
Range on Protein: 256-318
Range on HMM: 1-63/69.0
VVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHDTLAEY
|||||.| ||.|.|| |   . ||  .  .|||| . ..|  |  .| .| .|.||||.|.| 
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvea

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 52-166 1.1e-15 52.2 In-house 53-164 (301) alignment
Range on Protein: 52-166
Range on HMM: 53-164/301.0
KNRFANVvAYDHSRVVLSLTenDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNRKTENHGPL
|.|. .|   . |  |  ..  |     | ||...|    . .||||||| .|  ||| |.   .   |||... .||  .||. | |.| ... . |  
khryptv.PckPstaveviv..dGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrf

TITFVQEETFAYYSI
.|. ...|.    .|
kikiknkelilnkki

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 48-124 1.2e-15 51.9 In-house 46-115 (303) alignment
Range on Protein: 48-124
Range on HMM: 46-115/303.0
ENQMKNRFANVVAYDHSRVVLSltendqSSHYINANYVDTyNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMIT
.|  ||||..|.  |||.| ||       | || |.|..  .. .  | || ||..| .|||.|| ||. ...... 
knmdknrfvdvicldhskvkls......dssyihasylel.dsskkailtqlplshtaadfwqmiieqkvkcvllll

0048076 (Phosphotyrosine protein) phosphatases II 486-602 4.3e-15 51.1 In-house 13-119 (145) alignment
Range on Protein: 486-602
Range on HMM: 13-119/145.0
FGDYEVTMESETARGDFIIRD--LkliSTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEveknshqfDiiGPIVVHCNNGIGRTGVYC
.|.. .... |. .   | .   |   ..  . . |.. ....| || || | . ...|...  .||. .|        .  ||..|||. |.||||...
lgslptaldlellkdlgittvlnl...tselellerlgiqylylpwpDhgvpdllellleflefieealke........g..gpvlVHCsaGvgRtgtlv

ALHALWQ-QITQEKLVSVYQ
|.. ... ... |. .  ..
aaylmlllgvsleealelvr

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 86-177 6.4e-15 49.4 In-house 230-317 (440) alignment
Range on Protein: 86-177
Range on HMM: 230-317/440.0
DTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKgrhKCAMYWPTKNRkTENHGPLTITFVQEETFAYYSIRTFEIKPNKDG
. |   ||.|||| ||  |. ||||.. . .   |.|. .. .|    |..||| . | .   ||.|.     | .    .||.|.| ... 
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntr.svtfgpftvghkgsenmnrvkvrtlelkykeev

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 210-318 7.3e-15 49.4 In-house 180-282 (290) alignment
Range on Protein: 210-318
Range on HMM: 180-282/290.0
VKPMMVKQFHFTGWPDHGAPEPGFEfpvldlIMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYI
 |  ..| ..   |||.  .   .       ...    .   .||.|||||||.||.|.|. |.  .. . |  .||. .    .|| |   || . ||.
Gkehklkhlkikswpdksvalstla......llrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqyl

FIHDTLAEY
 . . | ..
alveilldl

subfamily_eak_pd Subfamily eak 36-179 1.3e-14 48.4 In-house 39-179 (332) alignment
Range on Protein: 36-179
Range on HMM: 39-179/332.0
NKRLTWVQSQKPENQMKNrFANVVAYDHSRVVLSLTENDQsSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCA
.. |.  .... |.  .|   ..| ||.  | |. .  ..   ||||  ..  .  . || |  .  . .  ||.|. ||.   ||.. . .|..  |  
qrllsisetarleavnrn.vvkivpydrylvrltssqlnr.lGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksd

MYWPTKNRKTENHGPLTITFVQEETFAYYSIRTFEIKPNKDgTH
 |.| | |.  ..| | ..  .    . .  | .|..   . ||
kyfpdktreelkfGildverkefvkrniletrllelskGne.th

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 397-586 3.2e-14 47.2 In-house 56-232 (303) alignment
Range on Protein: 397-586
Range on HMM: 56-232/303.0
ICVIDSSRVRLyprpgeEGSDYINASYIDGFTRREAfIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHDTAHFGDYEVTMeSE
. ..| |.|.|        | || |||..  ... | | || ||. |. |.|.|| ... . ...||.. |.||    | .|   |  .| .  . .  |
vicldhskvkl......sdssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersirv.ge

TARGDFI-IRDLKLISTKDPSVIRQIRHFHFLHWPEHGQPWSGQTvlQLVSKVEEWESEVEKNSHQfdiiGPIVVHCNNGIGRTGVYCALH
  | ..     ||..|  . .    .   |.  ||    |  |    ..| .. . .| . | |.      | |     | ||.| .. . 
fkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgsp..kfvkqiwqlqsvlrkysds....tptvymslsgcgragtfalfe

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 399-595 4.5e-14 47.3 In-house 29-221 (290) alignment
Range on Protein: 399-595
Range on HMM: 29-221/290.0
VIDSSRVRLYPRPGEEGSDYINASYIDgFTRREAFIATQHPL-------QSTTMDYWRMIWQENCRSIVMLLSEKEWDKD--VF--PSYLPAVHD-TAHF
..  .|| |        .||| |...  .    ..|.|| |.       .||  ..| |. ||. ...|||   .| ...   |    | |   .    |
LveatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkf

GDYEVTMESETARGDFIIRDLKLisTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESeveknshqfdiigPIVVHCNNGIGRTGVYCALH
.. .|   |  .  |...| | .  . |  .  .. |  .  | .   . . .|.|.|..||.  ..             |..||| .|| |  .  |. 
kgltvkCkskekeddvetRelvv..kfddeeeftvtHsllkgWnklnvqedtktllsliqkvkaskt.............pvivHcvdGiSrsAalaaii

ALWQQITQE
  .| | . 
lgyQkiaet

subfamily_CG42327_pd Subfamily CG42327 252-320 5.1e-14 46.7 In-house 247-316 (319) alignment
Range on Protein: 252-320
Range on HMM: 247-316/319.0
TGPLVVHCSAGVGRSGAFIVIDSMIKRIHDN-GDLDIFNFLAHIRNQRNHLVQEECQYIFIHDTLAEYIA
 |||||||| ||||.|  |  |  |... ..   .|| . . ..|..| . |..  || ||. .| || .
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak

subfamily_hpo-7_pd Subfamily hpo-7 93-320 5.5e-14 46.7 In-house 39-228 (263) alignment
Range on Protein: 93-320
Range on HMM: 39-228/263.0
AYIAtqgpLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNRKTENHGPLTITFVQEETfaYYSIRTFEIKP---NKDGTHYTQYMhgtmf
 |.     | .||  |...|  ..  |.||...  |.|. ||  |.|..  .      ....  .        ..| |.     .|  ||  .       
lysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhy.....

dssastnmlldesldplddevkpmmvkqfHFTGWPDHGAPEPGFEfpVLDLImKstacVVPGTGPLVVHCSAGVGRSGAFIVIDSMIK----RI--HDNG
                              ..||... .||   |  .| .. |    |. .  .||||||.|.||| || |.... .     .   . .
.............................sykgWiekndpelare..ilnil.k....varnskslvvhcstGiGrsaafsvaElvyqkmirsldttstv

DLDIFNFLAHIRNQRNHLVQEECQYIFIHDTLAEYIA
.||  ..| ..|..|.  ...  |  |   .. ... 
eldylsLleelrssrkraihtPmqLafsilmvLdfvl

0048179 (Phosphotyrosine protein) phosphatases II 515-599 1.5e-13 46.2 In-house 43-118 (144) alignment
Range on Protein: 515-599
Range on HMM: 43-118/144.0
PSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWeseveknsHQFDiiGPIVVHCNNGIGRTGVYCALHAL-WQQITQEKLVS
....|.. ....| || || | . . .|...  .||.        .. .  ||..|||. |.||||...|.. .  .... |. . 
efleregiqylhlpwpDhgvpdllellleflefieea........leeg..gpvlVHCsaGvgRtgtlvaaylmkklglsleeala

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 210-310 2.7e-13 44.3 In-house 178-272 (301) alignment
Range on Protein: 210-310
Range on HMM: 178-272/301.0
VKPMMVKQFHFTGWPDHGAPEPGFE-FPVLDLIMKSTAcvvpgtgPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQY
...  |  . .. |.|.| |.   | | ...|. ||         |.|||||||.||| |||  . . .... .  ... . |.|.|..| . || . | 
fatrtvthyqysewtdrgvPkshaelfdlmelvkksek.......PivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsql

IF
 .
yw

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 53-138 1.9e-12 41.5 In-house 47-128 (312) alignment
Range on Protein: 53-138
Range on HMM: 47-128/312.0
NRFANVVAYDHSRVVLSLTENdqssHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYW
||. |.  .|  |  |.  ||     || ||.|      . ...||||| .|.. ||..     .  |.... ..| | .||| | 
nrypniqcwdrgrftlagden....fyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyi

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 48-125 2.8e-12 40.8 In-house 36-118 (347) alignment
Range on Protein: 48-125
Range on HMM: 36-118/347.0
ENQMKNRFANVVAYDHSRVVLSlTE------NDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITN
 .  |||  .|   | .|||||  |       |..  |||| ..   || . || || || .|. |||.|.   .   .| | .
kslsknrskdvklidatrvvls.peksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtife

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 49-134 2.8e-12 40.8 In-house 34-118 (332) alignment
Range on Protein: 49-134
Range on HMM: 34-118/332.0
NQMKNRFANVVAYDHSRVVLslTENDQSSHYINANYVDTYNAMNAYIATQGPLAK-TISDFWRMIWEQNCRVIVMITNIIEKGRHKC
|   ||   . ..||||| |  . .|    . ||..|| |.  .||| .| |.   |   ||||. |..  .|... .| || ..|.
nmdmnriphlycfdhsrvel..apqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 216-320 2.9e-12 40.9 In-house 179-277 (312) alignment
Range on Protein: 216-320
Range on HMM: 179-277/312.0
KQFHFTGWPDHGAPEpgfefpVLDLIMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHDTL
... .. ||||| |.        |  ..  ..|     |.. ||||||||.|....|.|||  .      .. . .  .|..|   |.   ||..   ..
nhyqwaswpdhgmpd......scdtalrllsavkkdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcv

AEYIA
 |.. 
lefly

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 440-593 3.5e-12 41.0 In-house 36-176 (255) alignment
Range on Protein: 440-593
Range on HMM: 36-176/255.0
LQSTTM-DYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHDT-AHFGDYEVTMESetARGDFIIRDLKLISTKD-PSVIRQIRHFHFLHWPEHGQPW
|.| |.  ....| | .   .|||   .| ...   ||.|  .|    . | .||     .  | ..| |...||       ....|...  |.|.  | 
lysltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPe

SGQTVLQLVSKVeeweseveKNSHqfdiigPIVVHCNNGIGRTGVYCALHALWQQIT
  . .|...  |        ..|.      ..||||..||||.  .     ..|.. 
lareilnilkvv........rdsk......svvvhCstGiGrsaafvlaelvyqkmi

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 92-174 3.8e-12 40.8 In-house 5-87 (199) alignment
Range on Protein: 92-174
Range on HMM: 5-87/199.0
NAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNRKTENHGPLTITFVQEETFAYYSIRTFEIKPN
  ||||| || .|..|||.|.||     |||. .   .     ..|||| .  | ..| |..|     | . |.| .. .  |
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnn

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 92-174 3.9e-12 40.7 In-house 4-86 (198) alignment
Range on Protein: 92-174
Range on HMM: 4-86/198.0
NAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNRKTENHGPLTITFVQEETFAYYSIRTFEIKPN
  ||||| || .|..|||.|.||     |||. .   .     ..|||| .  | ..| |..|     | . |.| .. .  |
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnn

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 411-470 7e-12 39.5 In-house 117-176 (244) alignment
Range on Protein: 411-470
Range on HMM: 117-176/244.0
PGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDK
 |  |  |||||..  . |   .| |||||  |.||.|.|. .     .|.| | .| |.
kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 241-314 8e-12 39.6 In-house 217-290 (297) alignment
Range on Protein: 241-314
Range on HMM: 217-290/297.0
IMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHDT
 ..|     |   .|.|||||||||||  .  | .....  .   |.  .| ..|.||  |||   |. ...| 
qleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellyda

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 211-314 1.2e-11 39.2 In-house 114-216 (255) alignment
Range on Protein: 211-314
Range on HMM: 114-216/255.0
KPMMVKQFHFTGWPDHGAPEPGFEfpVLDlIMKstacVVPGTGPLVVHCSAGVGRSGAFIVIDSMIK----RI--HDNGDLDIFNFLAHIRNQRNHLVQE
|   || ....||... |||   |  .|  |.|    ||  . ..|||||.|.||| ||...... .     .   . ..||  ..| ..|..|.  ...
kthtvkhysykGWieknaPelare..iln.ilk....vvrdsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraiht

ECQYIFIHDT
  |  |   .
Plqlafsilm

subfamily_eak_pd Subfamily eak 397-590 1.3e-11 38.4 In-house 60-261 (332) alignment
Range on Protein: 397-590
Range on HMM: 60-261/332.0
ICVIDSSRVRLYPRPgEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVH-DTAHFGDYEVTMES
|   |   ||| .    .   ||||| ..     . .| |  . ..  . .|.|. ...  .||.|| . | . . .  |.|    .  .|| ..|.  .
ivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverke

ETARGDFIIRDLKLISTKDpsvIRQIRHFHFLHWPEHGQPWSGQ-----------TVLQL-VSKVEEWESEVEKNSHQFDIIGPIVvHCNNGIGRTGVYC
   |. .  | |.|    .     .. |...  | |   |   .            ||.| | | .  .| . |  |      ||.  . .|  |.||. 
fvkrniletrllelskGne...thrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfapii.qsarGsaraGvfv

ALHALWQ
 .  | .
vidllir

subfamily_hpo-7_pd Subfamily hpo-7 443-593 4.1e-11 37.3 In-house 46-182 (263) alignment
Range on Protein: 443-593
Range on HMM: 46-182/263.0
TTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHDTA-HFGDYEVTMESETArgDFIIRDLKLISTKD-PSVIRQIRHFHFLHWPEHGQPWSGQT
|   ....| | .   .|||   .| ...   ||.|  .|    . . .|.        | ... |.|.|| .    .....|. .  |.|. .|   . 
tidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpelare

VLQLVskveewesEVEKNSHqfdiigPIVVHCNNGIGRTGVYCALHALWQQIT
.|...        .| .||.      ..||||..||||.  .     ..|.. 
ilnil........kvarnsk......slvvhcstGiGrsaafsvaElvyqkmi

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 61-183 4.3e-11 37.2 In-house 5-114 (130) alignment
Range on Protein: 61-183
Range on HMM: 5-114/130.0
YDHSRVVlsltendqSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRhkcamYWPTKNRKTENHGPLTITFVQEET
.. ||.           .||||..|   .  . |. || |||.|  |||.|. |.   |.|..  . |.       |||  .        ...|  . . 
fevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede.....ywpdsePlewyeediivtltdrde

FAYYSIRTFEIKPNKDGTHYTQY
| .     .||. .   .| .  
fknikasnleiesdlneshqalt

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 386-463 6.7e-11 36.2 In-house 32-107 (332) alignment
Range on Protein: 386-463
Range on HMM: 32-107/332.0
LSGVPLRRVPRICVIDSSRVRLYPRPGEEgsDYINASYIDGFTRREAFIATQHPLQSTT-MDYWRMIWQENCrSIVMLL
|  . . |.|.. ..| ||| | |. |..  |. |||..||.... |.| .| |..  |   .|||. . .  |.....
lnnmdmnriphlycfdhsrvelapqdgkd..dfynaswvdgyskksayifaqapfndhteyvfwrmvserkp.smilvf

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 398-604 7.8e-11 35.9 In-house 61-257 (302) alignment
Range on Protein: 398-604
Range on HMM: 61-257/302.0
CVIDSSRVRLyprpGEEGSDYINASYIDGFTRREAFIATQHPLQSTT---MDYWRMIWQENCRSIVMLLSEKEWDKdVFPSYLP-AVHDTAHFGDYEVTM
 ..|| .|.|    ..|  .|.||| ..    ..  | .| | ....    ..|||..||.. |.|.|. |.| .|  .  ..|    |  ..|.  |  
pildsnlvkl....eaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNn

-----ESETArGDFIIRDLklISTKDPSVIRQIRHFHFlhWPEHGQPWSGQTVLQLVSKVeeWESEVEKNSHqfdiigpIVVHCNNGIGRTGVYCALHAL
      .|..   ..|  |        ||. .. ....  |...  | .  .. . . ||  ...... ...       .|.  .||.|| |.  .| . 
rkVekaeeek.tryviEvl..Pegcsnsvlanvyvltn..Wkqkkvpvkyaeliktaakv..fakkikaden.......tvivSknGaGRagafltlava

WQQITQEKLVSVYQTA
 ......| . . ...
veklqkgkepnikeiv

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 436-595 1.2e-10 35.3 In-house 96-251 (302) alignment
Range on Protein: 436-595
Range on HMM: 96-251/302.0
TQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFP-SYLPAVHDTAHFGDYEVTM-------ESETARGDFIIRDLKLISTKD-PSVIRQIRHFHF
   | .||.  .| .| | |   .| | | .| ..  .   |   | .. .|| | |.        |  | . .| .  ...  .|    | . .  ..|
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf

LHWPEHGQPWSGQTVLQLVSKVEEWESEVeknshqfdiigpiVVHCNNGIGRTGVYCALHALWQQITQE
  ||.|| |   .| |...   | .  .|             .||| .|.||||   |.    |  ...
sawpdhGapkeaytaldilkfcesykknv.............lvhcsaGvGrtGtlvaikyGiqlcskk

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 207-318 1.9e-10 34.9 In-house 161-268 (281) alignment
Range on Protein: 207-318
Range on HMM: 161-268/281.0
DDEVKPMMVKQFHFTGWPDHGAPEPGfEfPVLDLIMKSTACvvpgTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDL-DIFNFLAHIRN-QRNHLVQE
  | .  .. .. .  |||   ||   |  .| .. |  |     . | |.||||||||||... ..  .. ||    | || . ..|.|   |   || 
syegetrlithwlwkewpdwqvpess.e.vmlkilrkirar....stppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqt

ECQYIFIHDTLAEY
  ||..|   | ..
lqqymliwkvlldf

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 248-320 2.7e-10 34.1 In-house 214-286 (302) alignment
Range on Protein: 248-320
Range on HMM: 214-286/302.0
VVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHDTLAEYIA
 .... ..|.    |.|| |||..    ....... .  | . .. ||.|| . |.  .||.... .|. || 
kikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyik

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 414-476 3.9e-10 34.0 In-house 81-149 (350) alignment
Range on Protein: 414-476
Range on HMM: 81-149/350.0
EGSDYINASYIDGF----TRREAF--IATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSY
...|||||.|.            |  |||| ||.||  |....| . . . |..| |. | . . .  |
stnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrY

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 48-179 5.9e-10 32.2 In-house 25-120 (169) alignment
Range on Protein: 48-179
Range on HMM: 25-120/169.0
ENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINAnyvdtynamnayiatqgplaktisdfwRMIWEQNCRVIVMITNIIEKgrhkcAMYWPTKNRKtEN
 |. ||| |  .|  | || |    .| .| ||||                           ||||| |  |||.. .  .|       .|| |.   . 
cnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddk.....nnfwpekedy.ql

HgPLTItFVQEETFAYYsIRTFEIKPNKDGTH
| |  | . .  | . | .||  ..||  | .
h.pavi.lGewytdsly.vrtdkvhpntsgve

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 47-178 7.1e-10 32.1 In-house 25-120 (169) alignment
Range on Protein: 47-178
Range on HMM: 25-120/169.0
PENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINAnyvdtynamnayiatqgplaktisdfwRMIWEQNCRVIVMITNIIEKgrhkcAMYWPTKNRKtE
  |. ||| |  .|  | || |    .| .| ||||                           ||||| |  |||.. .  .|       .|| |.   .
tcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddk.....nnfwpekedy.q

NHgPLTItFVQEETFAYYsIRTFEIKPNKDGT
 | |  | . .  | . | .||  ...| .| 
lh.pavi.lgewytdsly.vrtdkvhantsgv

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 48-173 7.6e-10 33.4 In-house 18-152 (290) alignment
Range on Protein: 48-173
Range on HMM: 18-152/290.0
ENQMKNRFANVVAyDHSRVVLSLTENDQSSHYINANYVDTYNAMnAYIATQGPLAKT-------ISDFWRMIWEQNCRVIVMITNIIEKGRH----KCAM
...|..| .. ..  ..||||    .  .. || ||.|   | . . |.|| |..|.       | .|| |. . . . .||. .  || ..     || 
khemdqRlevpLv.eatrvvLkgygkrfnddyiHAnrvtcpngl.rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCak

YWPTKNRKTENHGPLTITFVQEETFAYYSIRTFEIKP
| |..  .  . . ||.   . |.     .|. ..| 
YvpesvgeelkfkgltvkCkskekeddvetRelvvkf

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 209-315 1.8e-09 31.6 In-house 186-286 (310) alignment
Range on Protein: 209-315
Range on HMM: 186-286/310.0
EVKPMMVKQFHFTGWPDHGAPEPGFEFPVLDLImkstACVVpgTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQY
..| . |.  ..  ||| | |.         |.    | |    || |||||||..| .. . ..  |....    .|. .  ......|   .| | ||
nlkelrvslikwpnwpdrgvpdekchtvpqrll....aqvr..hgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqy

IFIHDTL
..|.   
liidrvr

subfamily_eak_pd Subfamily eak 243-320 2e-09 31.3 In-house 228-306 (332) alignment
Range on Protein: 243-320
Range on HMM: 228-306/332.0
KSTACVVPGTGPlVVHCSAGVGRSGAFIVIDSMIKRIHDN--GDLDIFNFLAHIRNQRNHLVQEECQYIFIHDTLAEYIA
|      |   | .. .. |  |.|.|.||| .|. | ..      . ...  ....|.| |  . |. ||.. . .|. 
kkyihtppsfap.iiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyll

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 512-592 3.6e-09 30.8 In-house 211-289 (350) alignment
Range on Protein: 512-592
Range on HMM: 211-289/350.0
TKDPSVirqIRHFHFLHWPEHGQPWSGQTVLQLVS-KVEEWESEVEKNSHQFDIIGPIVVHCNNGIGRTGVYCALHALWQQI
. || |   . ....  |.. .     . .|| .  | .  .. . ..  . .   ||.|||  |.||||....|  | ...
asdPyv...vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdf

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 415-474 5.8e-09 30.3 In-house 12-70 (130) alignment
Range on Protein: 415-474
Range on HMM: 12-70/130.0
GSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDkDVFP
| .|||||..    |   .. |||||  |.||.|.|. .     .|.| | .| | . .|
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed.eywp

subfamily_ptpA1_pd Subfamily ptpA1 215-279 5.9e-09 30.1 In-house 188-256 (418) alignment
Range on Protein: 215-279
Range on HMM: 188-256/418.0
VKQFHFTGWPDHGAPEPGFEFP-VLDLIMKSTACVVPGT---GPLVVHCSAGVGRSGAFIVIDSMIKRI
. |... |||||  |.    |  .|  | .    ..| .    |..|||||||||.|.|     |.|..
itqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkl

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 215-330 1.1e-08 29.1 In-house 173-290 (303) alignment
Range on Protein: 215-330
Range on HMM: 173-290/303.0
VKQFHFTGWPDHGAPEPGFEFPVLDL-IMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDN-GDLDIFNFLAHIRNQRNHLVQEECQYIFIH
..  |.  ||    |  |    | ..  ..|       . | |    .|.||.|.| ....    .|..   ||. . |  .|| | | ||. .|. ...
lhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvy

DTLAEYIACNFVISLPIK
  |||..  | .. | | 
tllaehvldngicklaip

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 45-87 2e-08 28.0 In-house 43-85 (440) alignment
Range on Protein: 45-87
Range on HMM: 43-85/440.0
QKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDT
  |.|..|||. |..|||||||.|   .   .|.|||| |.. 
slpnnkvknryrnilaydhsrvmleevkgvpdsdyinasying

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 399-463 1.5e-07 25.3 In-house 48-117 (347) alignment
Range on Protein: 399-463
Range on HMM: 48-117/347.0
VIDSSRVRLYPRPG-----EEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLL
.||..|| | |        ..   |||||.|     .. .| ||.|| .|  |.|.|.   .   .| ..
lidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 416-467 2.2e-07 24.6 In-house 90-143 (349) alignment
Range on Protein: 416-467
Range on HMM: 90-143/349.0
SDYINASYID--GFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKE
 ||||| |.    ..  . .|||| || ||  |....|  .. . .. | ..||
ddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddke

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 96-172 3.9e-07 24.4 In-house 39-106 (255) alignment
Range on Protein: 96-172
Range on HMM: 39-106/255.0
AtqgplakTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNRKTENHGPLTITFVQeeTFAYYSIRTFEIK
        |.  |...|  ..  |.||...  |.|. ||  |.|..  .      ...|  .  . |   .|| || 
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleit

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 28-88 4e-07 23.9 In-house 18-77 (244) alignment
Range on Protein: 28-88
Range on HMM: 18-77/244.0
EFEGVHEKNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENdQSSHYINANYVDTY
|| |. .. . .  ...    |  |||. |.. .|..||.|| ... ..| ||||||..  
efvglsdhtreflqtnavlsanatknryinilpfdetrvilssskk.egsdyinanyiqgs

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 214-313 6.5e-07 23.8 In-house 159-253 (290) alignment
Range on Protein: 214-313
Range on HMM: 159-253/290.0
MVKQFHFTGWPDHGAPEPGFEfpVLDLIMKstacVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIH-DNGDLDIFNFLAHIRNQRNHLVQEECQYIFIH
 |.   . || .  ..|      .|.||.|    |   . | .|||  |. || |.  |.     |   .|.. . . |  .|.||....... .. |. 
tvtHsllkgWnklnvqedtkt..llsliqk....vkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvd

D
 
a

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 511-591 1.1e-06 22.3 In-house 213-293 (349) alignment
Range on Protein: 511-591
Range on HMM: 213-293/349.0
STKDPSVIRQIRhfhFLHWPEHGQPWSGQTVLQLV-SKVEEWESEVEKNSHQFDIIGPIVVHCNNGIGRTGVYCALHALWQ--Q
....| .. |..   .  |.. .     ...|| .  | .  ..   ..  . |   ...|||  | |||||.. |  | .  .
avekPyellqlq...vknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsile

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 48-142 1.2e-06 22.2 In-house 50-142 (302) alignment
Range on Protein: 48-142
Range on HMM: 50-142/302.0
ENQMKNRFANVVAYDHSRVVLSltenDQSSHYINANYVDTYNAMNAYIATQGPLAKTI---SDFWRMIWEQNCRVIVMITNIIEKGRhKCAMYWPTKN
.|  ||.  .| ..|. .| |.     .  .|.||  |.  .  .  | .| |  ..     .||||......  .|..    |  .     ..|.| 
knlkknqsedvpildsnlvkle....aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkks

ERO1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) 45-120 1.6e-06 14.6 Pfam-A 71-145 (357) alignment
Range on Protein: 45-120
Range on HMM: 71-145/357.0
QKPENQMKNRFAN------VVAYDHSRVvlsLTENDQSSHyINANYVDTYNAMNAYIATQGPLAKTIsdfWRMIWEQNCRVI
.| |...|... .      |  .|  .     .| |....  .|.||| ..  ... . .|. |. .   ||.|.|.||  .
akdekelkesleevreskkvekldeldd...ycevddees.ekavyVdLlknperfTgYkGksaarv...WraiYeeNCfkk

0038934 (Phosphotyrosine protein) phosphatases II 523-586 1.6e-06 23.4 In-house 81-136 (194) alignment
Range on Protein: 523-586
Range on HMM: 81-136/194.0
HFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVEKNshqfdiigPIVVHCNNGIGRTGVYCALH
... | .|..| . | ...|. .. |.|. .| ...         ..|||  |.||||. .| .
eylklpfpddgtvPsleillrfldlvdeflnedpgg........vvaVHCkaGlgRtGtlvaaY

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 388-437 3.5e-06 21.1 In-house 48-94 (95) alignment
Range on Protein: 388-437
Range on HMM: 48-94/95.0
GVPLRRVPRICVIDSSRVRLYPRpgeEGSDYINASYIDGFTRREAFIATQ
 .|  |.  |   |..|| |  .     |||||| ..||..|....||.|
nipknrflnifpydatrvvlttk...rdsdyinacfvdgyarkncyiaaq

PTEN_1 208-270 3.9e-06 21.8 In-house 88-148 (196) alignment
Range on Protein: 208-270
Range on HMM: 88-148/196.0
DEVKPMMVKQFHFtGWPDHGAPEPGFEFPVLDLIMKSTACVVPgTGPLVVHCSAGVGRSGAFI
.| . . |.. || ...|||||   . | ... .. .     .  .  .||| ||.||||  .
eeffksgveylhf.pieDhgapslselfdicksfiewllsdpn.gnvVlVHCkaGlgRsGtvv