Gene PTPRN in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRN
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP082_AA protein Get Run
NvecP082_AA_166-446 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRN_pd Subfamily PTPRN 154-449 1.1e-179 590.5 In-house 1-296 (297) alignment 
Range on Protein: 154-449
Range on HMM: 1-296/297.0
SEEPVVPNMDISTGHVVLSYMEDHLSNKNRLNKEWEALCNYEAEPSVADLGKQDKNVRKNRYSDVLPYDHNRVSLRETANATGSDYINASFITDHDPRNP
||||||.|.|||||||||||.||||.||.||.|||||||.||||||.....|..|||.|||...||||||.||.|.|.|.|. |||||||.|.|||||.|
seepvvsnldistGhvvlsyledhlknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprap

AYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTRLSDLGLPQCHRYWPEDGHETYHIYEVHLVSEHIWCDDYLVRSFYLKNLQTSETRTVTQFHFLSWPDL
||||||||||.||.||||||||||||||||||||.. |. ||.||||..|.|.|||||||||||||||||||||||||||||||||||||||||||||. 
ayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpee

NVPTTPKPLLEFRRKVNKCFRGRSCPIVVHCSGGVGRTGCYILIDLVLNKMMRGAKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAEEVNAIL
.||...|.||||||||||..||||||||||||.|.||||.|||||||||....|.||||||||.||||||||..||||.|||||||||||||||||
gvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeevnail
subfamily_PTPRD_pd Subfamily PTPRD 177-447 1.4e-98 326.0 In-house 18-283 (564) alignment 
Range on Protein: 177-447
Range on HMM: 18-283/564.0
HLSNKNRLNKEWEALCNYEAEPSvaDLGKQDKNVRKNRYSDVLPYDHNRVSLRETANATGSDYINASFITDHDpRNPAYIATQGPLAHTVSDFWQMVWEQ
. ... ....|.. . . . ..   .  ... | .||||.....|||.|| |... .  ||||||||||  .. .. ||||||||||.|..|||.|||||
kansdlkfeeeykkieegqqftw..eaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPlaetiedFWRmvweq

GVVVIVNLTRLSDLGLPQCHRYWPEDGHETYHIYEVHLVSEHIwCDDYLVRSFYLKNLQTSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNKCFRGR
 . .|| ||.|.. |  .||.||||.|.|||  ..| |..|.    || .|.| ||. ..||.|.|.|||| |||| .||.....||...|||... .  
nsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeee.ladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepd

SCPIVVHCSGGVGRTGCYILIDLVLNKMMRgAKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAEEVNA
. ||||||| ||||||..| || .|...    | .||  .|..|| ||..||.|. |. |  .|..| ...
agPivVhCSaGVGRTGtfividamlerike.ektvDiyqyvkalrkqRnamVqteeQYiFiheailealac
0050432 (Phosphotyrosine protein) phosphatases II 146-448 2.3e-95 314.7 In-house 7-302 (308) alignment 
Range on Protein: 146-448
Range on HMM: 7-302/308.0
AKPPKYTWSEEPVVPNMDISTGHVVLSYMEDhLSNKNRLNKEWEALCNYEAePSVADLGKQDKNVRKNRYSDVLPYDHNRVSLretanATGSDYINASFI
| ...... ........   . . .| ..|. . .. .|..|.|.|...   .   . ... .|. ||||.|.|||||.|| |       ||||||||..
allelllfrdtsilvsslklsvldllkllek.aldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyv

TDHD-PRNPAYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTRLSDLGLPQCHRYWPED---GHETYHIYEVHLVSEHIwCDDYLVRSFYLKNLQTSETRT
. ..  .. ..||||||| .|| |||.|||||.| ||| ||.| . | ..|..|||..   | ..|. . |.|.||.. .||| || ..|.||...|.||
dgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.lddytvrtleltnlgdgesrt

VTQFHFLSWPDLNVPTTPKPLLEFRRKVNKCFrgRSCPIVVHCSGGVGRTGCYILIDLVLNKMMRGaKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAV
||.||...||| .||. |..||.| ..|.|..  ...||||||| ||||||..|..||.|. . .. ...|.  .| .|| |||.|| |. |..|   |.
vthfhytnWpdhgvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqleke.ggvdvfeavkklReqRpgmvqtpeqylflyral

AEEVNAI
.| .. .
leylklk
0051299 (Phosphotyrosine protein) phosphatases II 161-443 2.9e-94 311.0 In-house 2-284 (288) alignment 
Range on Protein: 161-443
Range on HMM: 2-284/288.0
NMDISTGHVVLSYMEDHLSNKNRLNKEWEALCNYEAEPSvADLGKQDKNVRKNRYSDVLPYDHNRVSLRETANATGSDYINASFItDHDPRNPAYIATQG
...||. ...  ... .......| .|.|.|... . ..    ..  .|. ||||||.|||||.|| |. . .  ||||||||.| |  ... ..|||||
dteisveellklvlkllangltglleefeellsllpdlt.lsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyi.dgynlkrkfIatqg

PLAHTVSDFWQMVWEQGVVVIVNLTRLSDLGLPQCHRYWPEDGHETYHIYEVHLVSEHIwCDDYLVRSFYLKNL----QTSETRTVTQFHFLSWPDLNVP
|| .||.|||.|||||.| ||| ||.| .||  .|..|||..|..||. . |.|.||.. .||| || ....||    ...|.||||.||...||| .||
PlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvp

TTPKPLLEFRRKVNKCFRGRSCPIVVHCSGGVGRTGCYILIDLVLNKMMRGaKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAE
..|..||.| |.|.|... ...|.||||| ||||||..|..||.|. . .. ...|.  .|..|| |||.|| |  |..|   |..|
dspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqleke.ggvdvleavkrlreqRpgmvqtpeqyrfvyealle
0040438 (Phosphotyrosine protein) phosphatases II 169-444 1.4e-89 295.8 In-house 5-275 (317) alignment 
Range on Protein: 169-444
Range on HMM: 5-275/317.0
VVLSYMEDHLSNKNRLNKEWEALCNYEAEpsVADLGKQDKNVRKNRYSDVLPYDHNRVSLRETANATGSDYINASFItDHDPRNPAYIATQGPLAHTVSD
..| ..  ..|....| .|.| |...  .    . ..  .|  ||||.|.|||||.|| |  . .  .|||||||.. |   .....||||||| .|| |
lllalldllksdftalleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyv.dgpnlkrkfIatqgPlpntved

FWQMVWEQGVVVIVNLTRLSDLGLPQCHRYWPEDGHETYHIYEVHLVSEHIwCDDYLVRSFYLKNLQTSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRK
||.||||||| |||.||.| .|| ..|..|||...  ||. . |.|.||.  .... .| . ...|..||.||||.||...||| .|| .|..||.| ..
FwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldflea

VNKCFRGRSCPIVVHCSGGVGRTGCYILIDLVLNKMMRGAkEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAEE
|.........|..||||.||||||..|...|.|. . ..  ..|.  .|..|| |||..| | .|..|  .|..| 
vrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.gvdveeavkelreqRpgavqtpeqyrflydalley
0039614 (Phosphotyrosine protein) phosphatases II 151-447 1.8e-89 295.4 In-house 1-291 (297) alignment 
Range on Protein: 151-447
Range on HMM: 1-291/297.0
YTWSEEPVVPNMDISTGHVVLSYMEDHLSNKNRLNKEWEALCNYEAEpsvADLGKQDKNVRKNRYSDVLPYDHNRVSLRETANA-TGSDYINASFITDHD
|.. .........|..... | .. .....|..| .|.| |...  .      ..  .|. ||||.|.|||||.|| |    .   .|||||||... .|
ylplrdallesipiplsvldlllllekansktllllefeellslkpd...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgyd

PRNPAYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTRLSDLGLpQCHRYWPEDGHeTYHIYEVHLVSEHIwCDDYLVRSFYLKNlqTSETRTVTQFHFLS
 .....||||||| .|| |||.||||||| |||.||.| .||  .|..||||.|  ||. . |.|....  .|.| || . ..|  ..|.||||.|....
lltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkveh.ldgytvrtlevtn..ngesrtvthfqytg

WPDLNVPTTPKPLLEFRRKVNKCFRG--RSCPIVVHCSGGVGRTGCYILIDLVLNKMMRGaKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAEEVNA
||| .|| ... |||| ..|.....   ...|..||||.||||||..|...|.|. . .. ...|.  .|..|| |||..| |  |..|   |..| .. 
wpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqleke.ggvdvleavkelreqRpgavqtpsqyrflydallellkr
0047943 (Phosphotyrosine protein) phosphatases II 173-443 3.5e-88 290.9 In-house 3-270 (273) alignment 
Range on Protein: 173-443
Range on HMM: 3-270/273.0
YMEDHLSNKNRLNKEWEALCNYEAePSVADLGKQDKNVRKNRYSDVLPYDHNRVSLretaNATGSDYINASFItDHDPRNPAYIATQGPLAHTVSDFWQM
.. ..|.....| .|.|.|...   .     ..  .|  ||||.|.|||||.|| |    .  ||||||||.. |  ......||||||| .|| |||.|
lllekllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyv.dgynlkrkfiatqgPlpntvedfwrm

VWEQGVVVIVNLTRLSDLGLPQCHRYWPEDG---HETYHIYEVHLVSEHIwCDDYLVRSFYLKNLQTSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKV
||||.| ||| ||.| .|| ..|..|||..|   ..||. . |.|.||.. .||| || ..|.||.|.|.||||.||...||| .||.....|||| ..|
vweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet.kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielv

NKCFRG--RSCPIVVHCSGGVGRTGCYILIDLVLNKMMRGaKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAE
.|...   .. |.|||||.||||||..|..||.|. . .. ...|.  .| .||.|||.|| |  |..|   |..|
rkalealpsngpvvVHCsaGvgRtgtfialdllldqleke.ggvdvleavkllrsqRpgmvqtpeqyrflyealle
0046845 (Phosphotyrosine protein) phosphatases II 184-447 5.8e-88 290.2 In-house 2-276 (284) alignment 
Range on Protein: 184-447
Range on HMM: 2-276/284.0
LNKEWEALCNYEAEPS-VADLGKQDKNVRKNRYSDVLPYDHNRVSLRETANA-TGSDYINASFITDHD----PRNPAYIATQGPLAHTVSDFWQMVWEQG
| .|.|.|...   ..   . ..  .|. ||||.|.|||||.|| |. . .   .|||||||... .|     .....||||||| .|| |||.|||||.
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

VVVIVNLTRLSDLGLPQCHRYWPEDG-HETYHIYEVHLVSEHIwCDDYLVRSFYLKNLQ-TSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNKCFR-
| ||| ||.| . |  .|..|||..|   ||. . |.|.||.. .||| || ..|.||. |.|.||||.||..|||| .||..|..|||| |.|..... 
vrvIVmltelvengrekcaqYwplegevltygdftvtllseev.kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

-GRSCPIVVHCSGGVGRTGCYILIDLVLNKMMRGAK--EIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAEEVNA
 ....|||||||.||||||..|..||.|. . ..    ..|.  .| .||.|||.|| | .|..|   |..| .. 
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
0043336 (Phosphotyrosine protein) phosphatases II 164-442 1.4e-86 285.7 In-house 2-274 (278) alignment 
Range on Protein: 164-442
Range on HMM: 2-274/278.0
ISTGHVVLSYMEDHLSNKNRLNKEWEALCNYEAepSVADLGKQDKNVRKNRYSDVLPYDHNRVSLRETANATGSDYINASFItDHDPRNPAYIATQGPLA
||. . .  ..| .|..| .| .|.| |...       . ..  .|. ||||.|.|||||.|| |  . .  .|||||||.. |  ......||||||| 
isvkdllkallelllnlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyv.dgynvprkfiatqgPlp

HTVSDFWQMVWEQGVVVIVNLTRLSDLGLPQCHRYWPeDGHETYHIYEVHLVSEHIwCDDYLVRSFYLKNLQTSETRTVTQFHFLSWPDLNVPTTPKPLL
.|| |||.||||.|| .||.||.| .|| ..|..||| .|..||. . |.|..|.  .||| || . ..||...|.||||..|.|.||| .||.....||
etvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeeh.lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslslll

EFRRKVNKCFRGRSCPIVVHCSGGVGRTGCYILIDLVLNKMMRGAkEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVA
.| ..|..... .. |..||||.||||||..|...|.|. ....  ..|.  .|..|| |||..| |  |..|   |..
dflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeg.gvdleeavkelreqRpgavqtpsqyrflyeall
0036941 (Phosphotyrosine protein) phosphatases II 175-445 4.6e-86 284.1 In-house 6-277 (297) alignment 
Range on Protein: 175-445
Range on HMM: 6-277/297.0
EDHLSNKNRLNKEWEALCNYEAEPSvADLGKQDKNVRKNRYSDVLPYDHNRVSLretaNATGSDYINASFItDHDPRNPAYIATQGPLAHTVSDFWQMVW
 ..|.....| ||.| |... . .|  . ..  .|. ||||.|.|||||.|| |    .  ||||||||.. |   .. ..||||||| .|| |||.|||
lekllflalllkefeellpllllgs.lsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyv.dgydlkrkfIatqgPlpntvedFWrmvw

EQGVVVIVNLTRLSDLGLPQCHRYWPED--GHETYHIYEVHLVSEHIW-CDDYLVRSFYLKNLQTSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNK
||.| |||.||.| .|| ..|..|||..  .  ||. . |.|.|.... .||| .| . .......|.||||.||...||| .||..|..||.| ..|.|
eqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrk

CFRG--RSCPIVVHCSGGVGRTGCYILIDLVLNKMMR--GAKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAEEV
. .   .. |..||||.||||.|..|..||.|. . .    ...||  .| .||.|||..| |  |..|   |..| .
vlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
0045450 (Phosphotyrosine protein) phosphatases II 162-443 1.4e-85 283.0 In-house 7-302 (307) alignment 
Range on Protein: 162-443
Range on HMM: 7-302/307.0
MDISTGHVVLSYMEDHLSNKNRLNKEWEALCNYEAE-PSVADLGKQDKNVRKNRYSDVLPYDHNRVSLRETANA-TGSDYINASFITDHDP-------RN
. |.. . .| .....|.....| ||.| |.... . .   . ..  .|  ||||.|.|||||.|| |  . .   .|||||||.......       ..
lfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlk

PAYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTRLSDLGLPQCHRYWPEDGHE-TYHIYEVHLVSEHIwCDDYLVRSFYLKNL-QTSETRTVTQFHFLSW
 ..||||||| .|| |||.|.||||| |||.||.| .|| ..|..|||..|.| ||. . |.|.||.. .|.| || . ...| .|.|.||||.||...|
rkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgw

PDLNVPTTPKPLLEFRRKVNKCFRG--RSCPIVVHCSGGVGRTGCYILIDLVLNKMMRGAKE--IDIAATVEHLRDQRPHMVKTKAQFEFALTAVAE
|| .||.....||.| ..|.|...   ...|..||||.||||||..|...|.|  . .. .   .|.  .|..||.|||..| .  |..|   |..|
pdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
DSPc_SM00195 185-445 4.7e-84 277.2 In-house 3-262 (263) alignment 
Range on Protein: 185-445
Range on HMM: 3-262/263.0
NKEWEALCNYEAEPsVADLGKQDKNVRKNRYSDVLPYDHNRVSLRETANATGSDYINASFITDHdPRNPAYIATQGPLAHTVSDFWQMVWEQGVVVIVNL
..| | | ... .    . ....||..||||...|||||.|| | .. . .|||||||..|. .  .. .|||||||| .||.|||.||||..| .|| |
keefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivml

TRLSDLGLPQCHRYWPED--GHETYHIYEVHLVSEHIWCDDYLVRSFYLKNLQTSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNKCFRGRSCPIVV
|. .. |  .|.|||||.  | ||.. ..|.||....  |.. .| . |.. ...|||.|||... .||| .|| ..|..||. |.|.|. .  | ||||
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSGGVGRTGCYILIDLVLNKMMRGAKeIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAEEV
||| ||||||....||..|.|. .. | .|| ..|..||.|||.||.|..|. |. .|..| .
hCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 185-445 4.7e-84 277.2 In-house 3-262 (263) alignment 
Range on Protein: 185-445
Range on HMM: 3-262/263.0
NKEWEALCNYEAEPsVADLGKQDKNVRKNRYSDVLPYDHNRVSLRETANATGSDYINASFITDHdPRNPAYIATQGPLAHTVSDFWQMVWEQGVVVIVNL
..| | | ... .    . ....||..||||...|||||.|| | .. . .|||||||..|. .  .. .|||||||| .||.|||.||||..| .|| |
keefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivml

TRLSDLGLPQCHRYWPED--GHETYHIYEVHLVSEHIWCDDYLVRSFYLKNLQTSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNKCFRGRSCPIVV
|. .. |  .|.|||||.  | ||.. ..|.||....  |.. .| . |.. ...|||.|||... .||| .|| ..|..||. |.|.|. .  | ||||
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSGGVGRTGCYILIDLVLNKMMRGAKeIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAEEV
||| ||||||....||..|.|. .. | .|| ..|..||.|||.||.|..|. |. .|..| .
hCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 181-447 1.6e-83 275.4 In-house 19-282 (318) alignment 
Range on Protein: 181-447
Range on HMM: 19-282/318.0
KNRLNKEWEALCNYEAEPSVADLgKQDKNVRKNRYSDVLPYDHNRVSLRETANATGSDYINASFItDHDPRNPAYIATQGPLAHTVSDFWQMVWEQGVVV
.  |..|.|.|   |....  .   .. | .|||| ..|.||| || |..... .|||||||..| |   |. ||||.|.||..|..|||.|||||.  |
elllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyi.dGyrrkkayiaaqaPlpetieDfWrmvWeqnsav

IVNLTRLSDLGLPQCHRYWPEDGHETYHIYEVHLVSeHIWCDDYLVRSFYLKNLQTSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNKCF-RGRSCP
|| ||.... |  ..|||||..| ..|    |.| . .. ..||..|.| ... ...|.|.| |.|. |||| .||. .  ||.. |.|.|   .    |
ivmltqeeergkakvhryWPskgsrsygklvvelke.evelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagp

IVVHCSGGVGRTGCYILIDLVLNKMMRgAKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAEEVNA
||||||.|||||| .| .| .|...    . .|.  ||..||.||. ||.|. |.||  ... | ...
ivvhCsaGvGrtGvfiavdillerika.ealvDvfqtvkqlreqrnlmvqtedqyefiydvllealas
0045098 (Phosphotyrosine protein) phosphatases II 204-445 1.4e-80 265.9 In-house 28-272 (278) alignment 
Range on Protein: 204-445
Range on HMM: 28-272/278.0
GKQDKNVRKNRYSDVLPYDHNRVSlretanatgsDYINASFITDHdprNPAYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTRLSDLGLPQCHRYWPEDG
.   .|. ||||.|.|||||.||           ||||||.|. .   ....||||||| .||.|||.|.||.|. |||.||.| .||   |..||||.|
alylgnldknRykdilpydhsrVk..........dYINAsyidgy...pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpegg

HETYHIYEVHLVSEHIWcDDYLVRSFYLKNL----QTSETRTVTQFHFLSWPDLNVPTTP--KPLLEFRRKVNKCFR-------------GRSCPIVVHC
..||. ..|.|.||... ||| .| ... ||    .. |.|.||..|.|.||| .||..|  |..||. . .... .             ....|..|||
sltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHC

SGGVGRTGCYILIDLVLNKMmrgAKEIDIAATVEHLRDQRPH-MVKTKAQFEFALTAVAEEV
| ||||||......|.|  .    . .|.  .|..|| |||. .| .. |..|   ...| .
saGvgRtGtlvaaylmlell...eggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 180-446 7.6e-80 263.3 In-house 25-291 (298) alignment 
Range on Protein: 180-446
Range on HMM: 25-291/298.0
NKNRLNKEWEALCNYEA--EPSVADLGKQDKNVRKNRYSDVLPYDHNRVSLRETANATGSDYINASFITDHDPRNpAYIATQGPLAHTVSDFWQMVWEQG
.  ....|.. | . .   |    . .....| .||||.|....|. || |... .   ||||||||.  .. || |.||||.|| .||.|||.||.|. 
kltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn.afiatqaPltetvedFWrmvteed

VVVIVNLTRLSDLGLPQCHRYWPEDGHETYHIYEVHLVSEHIWCdDYLVRSFYLKNLQTSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNKcFRGRS
. .|| || | .|.  ..|.|||..|.|||   .|.| |..    |. || . ... .....|.| |.|| ||||  ||.. . .|...|||..  . ..
igtiVmltnleeldktkyhkywPdegketygeitvsllskeefa.dlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra.sqqqa

C--PIVVHCSGGVGRTGCYILIDLVLNKMmRGAKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAEEVN
   |..|.|| ||||.| .| || ||... .  . .|.  .|. || .||..|.|..|. |  .|| | ..
gnkpvivqCsaGvgRsGtfiaidsvlerv.kkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald
subfamily_PTPN12_pd Subfamily PTPN12 200-451 7.9e-79 259.5 In-house 31-283 (290) alignment 
Range on Protein: 200-451
Range on HMM: 31-283/290.0
VADLGKQDKNVRKNRYSDVLPYDHNRVSLRETANATGSDYINASFITDHDpRNPAYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTRLSDLGLPQCHRYW
 .. |....||.|||| |.||||..|| |... .  |||||||.||   .  . .|||.||||..|..|||.|.||. | ..| . |. .||  .|.|||
steagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgve.gkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYW

PEDGHET--YHIYEVHLVSEHIWCDDYLVRSFYLKNLqtSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNKCFRGRSCPIVVHCSGGVGRTGCYILI
|| |.|.  .  .|| | .|.   ||.|.|.. ...   .|.|.|.|||. .||| .||...|.|||. ..|..  .  . |.||||| ||||||  | |
peegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiai

DLVLNKMMRGAK--EIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAEEVNAILQA
|.| . . ..    |.|.   | .|| ||. .|.|| |.|.   |||| |.. |..
dyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkelei
0042113 (Phosphotyrosine protein) phosphatases II 206-442 1.5e-78 258.9 In-house 6-240 (245) alignment 
Range on Protein: 206-442
Range on HMM: 6-240/245.0
QDKNVRKNRYSDVLPYDHNRVSLRETANATGSDYINASFItDHDPRNPAYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTRLSDLGLPQCHRYWPEDGHE
  .|. ||||||.|||||.|| | .. .  .|||||||.. | . ..| .|||||||..|| |||.|.||.|. .||.||.. .|| ..|..|||.... 
lpenkdknrysdilpydhtrvklspdggdldsdyinasyv.dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesl

TYHIYEVHLVSEHIwCDDYLVRSFYLKNLQTSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNKCFR-GRSCPIVVHCSGGVGRTGCYILIDLVLNKM
||. . |.|.||.. .||| || . ..||...|.|.|...|.|.||| .||.... ||.| . |.|. . ... |..||||.||||||..|...|.|. .
tygdftvtllseeh.lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleql

MRGaKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVA
 .  .....  .|..||.|||..| |  |..|   |..
eke.lgvsleeavkelrsqRpgavqtpsqyrflyeall
Y_phosphatase Protein-tyrosine phosphatase 209-443 2e-78 258.4 Pfam-A 1-235 (235) alignment 
Range on Protein: 209-443
Range on HMM: 1-235/235.0
NVRKNRYSDVLPYDHNRVSLreTANATGSDYINASFITDHDpRNPAYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTRLSDLGLPQCHRYWP--EDGHET
| .||||.|.||||..|| |  . . . ||||||.... .. .. ..||||||| .|..|||.|||.. | ||| ||.| . |  .|..|||  |.. .|
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YHIYEVHLV-SEHIWCDDYLVRSFYLKNLQTS-ETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNKCFRGRSCPIVVHCSGGVGRTGCYILIDLVLNKM
|. ..|.|. .|. ....| .| . ||. ... |.|.|.|.|. .||| .||..||.||.. |||.|  . .| |.||||| ||||||.....|..|...
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

MRGAKeIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAE
 .. . .|.  .|..|| |||.||.. .|..|   |..|
eaeee.vdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 209-443 2e-78 258.4 In-house 1-235 (235) alignment 
Range on Protein: 209-443
Range on HMM: 1-235/235.0
NVRKNRYSDVLPYDHNRVSLreTANATGSDYINASFITDHDpRNPAYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTRLSDLGLPQCHRYWP--EDGHET
| .||||.|.||||..|| |  . . . ||||||.... .. .. ..||||||| .|..|||.|||.. | ||| ||.| . |  .|..|||  |.. .|
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YHIYEVHLV-SEHIWCDDYLVRSFYLKNLQTS-ETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNKCFRGRSCPIVVHCSGGVGRTGCYILIDLVLNKM
|. ..|.|. .|. ....| .| . ||. ... |.|.|.|.|. .||| .||..||.||.. |||.|  . .| |.||||| ||||||.....|..|...
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

MRGAKeIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAE
 .. . .|.  .|..|| |||.||.. .|..|   |..|
eaeee.vdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_PTPRA_pd Subfamily PTPRA 183-443 3.9e-78 257.6 In-house 33-293 (330) alignment 
Range on Protein: 183-443
Range on HMM: 33-293/330.0
RLNKEWEALCNYEAEpSVADLGKQDKNVRKNRYSDVLPYDHNRVSLRETANATGSDYINASFITDHDPRNpAYIATQGPLAHTVSDFWQMVWEQGVVVIV
.. .|..||   . . .. .| ....| .|||. ..||||..|| | .      |||||||||  .  ..  .||.|||...|| |||.|.|||    ||
lfreefnalPagpiq.atlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekd.kfiaaqGPkeetvedfwrmiweqksativ

NLTRLSDLGLPQCHRYWPEDGHETYHIYEVHlVSEHIWCDDYLVRSFYLKN----LQTSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNKCFRGRSC
 || | .    .|..|||..|  ||    |. | ..  . || || | ...     .  ..| |.|||| ||||. ||..|. .|.. .||.|. .  . 
mltelkerkeekcaqywPdeGlvtyGnirve.vedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag

PIVVHCSGGVGRTGCYILIDLVLNkMMRGAKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAE
||||||| |||||| .| .| ||. ...  . .|.  .|..|| |||.||.|. |.||   .. |
pivvhcsaGvGrtGtfivldavle.rvkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlle
0040439 (Phosphotyrosine protein) phosphatases II 206-443 1.4e-77 255.9 In-house 8-244 (249) alignment 
Range on Protein: 206-443
Range on HMM: 8-244/249.0
QDKNVRKNRYSDVLPYDHNRVSLRETANATGSDYINASFItDHDPRNPAYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTRLSDLGLPQCHRYWPEDGHE
  .|. ||||.|.|||||.|| |  . .  .|||||||.| |   .....||||||| .||.|||.|.||.|. |||.||.|  ||  .|..|||..|. 
lpenkdknrypdilpydhsrvklsilpglflsdyinAsyi.dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsl

TYHIYEVHLVSEHIwCDDYLVRSFYLKNLQTSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNKCFRG--RSCPIVVHCSGGVGRTGCYILIDLVLNK
.|. . |.|.|... .||| || ..|.||...|.|||.......||| .|| ....||.| ..|.|...   ...|..||||.||||||..|...|.|. 
eygdftvtllsvev.kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleq

MMRGaKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAE
. .  ...|.  .|..||.|||..| .  |..| . |..|
leke.lgvdleeavkllrsqRpgavqnpeqyrflyealle
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 179-448 1.7e-77 255.3 In-house 11-279 (281) alignment 
Range on Protein: 179-448
Range on HMM: 11-279/281.0
SNK-NRLNKEWEALCNYEAEpSVADLGKQDKNVRKNRYSDVLPYDHNRVSLRETANATGSDYINASFITDHDPrNPAYIATQGPLAHTVSDFWQMVWEQG
.|. . . .|.|.| . . . ..|   |.|.|| |||||..  ||. || . .. ... .|||||.|.   .  . .|||||||. ... .|||||||| 
qndnaGfieeyeklaaigvd.ntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykg.ekeyiatqgPvPaslvafWqmvweqk

VVVIVNLTRLSDLGLPQCHRYWPEDGHET-YHIYEVHLVSEHiWCDDYLVRSFYLkNLQTSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNKCFRGR
| .|| .||  . |  .||||||.| .|. |  . |. ..|.     |. | | | . ...|||.|.|.....|||  ||.|.| |||||..|.|. . .
vsaivmvtreieagklkChrYWPddnselkygdvtvkstaee.ekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekk

S-CPIVVHCSGGVGRTGCYILIDLVLNKMMRGAKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAEEVNAI
. .|.|.||| ||||||.|| .| ..... . ..|.|. |.|..|| .|  ||.| .|.||   || . ..  
tkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldke
subfamily_PTPRB_pd Subfamily PTPRB 174-442 2.2e-77 255.0 In-house 17-282 (293) alignment 
Range on Protein: 174-442
Range on HMM: 17-282/293.0
MEDHLSNKNRLNKEWEALCNYEAEPSVaDLGKQDKNVRKNRYSDVLPYDHNRVSLRETANATGSDYINASFITDHDPRNpAYIATQGPLAHTVSDFWQMV
.. .  .. |...|.| | . . . .| .  .. .|  ||||...|||||.|| | .... .|||||||..| ..  ..  .||||||| .|| |||.||
kkmkadsdlrfseeyeelkavgkdqav.kaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynspr.efiatqGPlpetvddfWrmv

WEQGVVVIVNLTRLSDLGLPQCHRYWPED-GHETYHIYEVHLVSEHIwCDDYLVRSFYLKNlqTSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNKC
||. . .|| ||.| . |  .|..|||.|    .|   .|.||.|.   .|. .|.. ...  ..|.|.|.|.||.|||| .|| ..|.||.| |.|.. 
wekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeee.ledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvrea

F--RGRSCPIVVHCSGGVGRTGCYILIDLVLNKMMRgAKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVA
     .. ||||||| |||||| .| .| .|... .    .||...| .|| .| ..|.|..|. |  ..| 
iektaskrPivvhCsaGvGRtGtfialdrllqaiee.edyvdifgivaelReeRnllvqtekqYifihqcvl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 178-442 7.7e-77 253.2 In-house 17-276 (288) alignment 
Range on Protein: 178-442
Range on HMM: 17-276/288.0
LSNKNRLNKEWEALCNYEAEPSVaDLGKQDKNVRKNRYSDVLPYDHNRVSLRETANATGSDYINASFITDHDpRNPAYIATQGPLAHTVSDFWQMVWEQG
 .|.. ...|...| . | . || . |.. .| .|||| ..||||..|| |..  . .|.||||||.| ... .. .|||||||||.|| |||..|.|. 
arnrtgfseeynsLaalektksv.tagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgek.kkkkyiatqgPladtvndfWelvyenk

VVVIVNLTRLSDLGLPQCHRYWPEDGH-ETYHIYEVHLVSEHiWCDDYLVRSFYLKnlQTSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNKCFRGR
.  || || | . |  .|..|||.... . |   .| ||...   .|...|.. |.  .. . ...||...|.||| .||   .||||..|.|.      
tstivmltelveggktkCeeYWPdadkpknyGsvtvtlvesk.eledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad

SCPIVVHCSGGVGRTGCYILIDLVLNKMMRgAKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVA
. ||.|||| |||||| .| .| ..... .  . ||.|.||..|| ||. .|.|. |.||   ...
tgpiivhCsaGvGrtgtFialdalidavee.edyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 173-447 8e-76 250.1 In-house 14-285 (319) alignment 
Range on Protein: 173-447
Range on HMM: 14-285/319.0
YMEDHLSNKNRLNKEWEALCNyeAEPSVADLGKQDKNVRKNRYSDVLPYDHNRVSLRETANATGSDYINASFITDHDPRNpAYIATQGPLAHTVSDFWQM
... . . .. |.||.. | .  |..   |  ....| .||||...|.||. || | |  .  ||||||||||  .. |. ..||||.||..|..|||.|
lkalastgetllekefkllke..avndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqere.kfiatqaPlentiedfWrm

VWEQGVVVIVNLTRLSDLGLPQCHRYWPEDGHETYHIYEVHLVSEHiWCDDYLVRSFYLKNLQTS-ETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNK
|||... ..| ||.|.. .  ....||||  .|.|  . | | .|.   .|| .| . |.....  |||.|..|....||| .||.. . ||.. ....|
vWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeee.eledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirk

CFRG-RSCPIVVHCSGGVGRTGCYILIDLVLNKMMRGAkEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAEEVNA
  ..  | ||||||| |||||| .| .| .|... . .  .|.  || .|| ||. ||....|..|   |. | |.|
srektqsgPivvhCsaGvGRtGtfivldamlervkeeg.vlDvfstvsrlRtqRnimvqrpeqYkfiyealleavea
subfamily_PTPN6_pd Subfamily PTPN6 175-445 2.1e-75 248.6 In-house 19-297 (306) alignment 
Range on Protein: 175-445
Range on HMM: 19-297/306.0
EDHLSNKNRLNKEWEALCNYEAEPSV-ADLGKQDKNVRKNRYSDVLPYDHNRVSLReTANATGSDYINASFIT-DHDPRNPAYIATQGPLAHTVSDFWQM
|..  .|. ...|.|.| . ||.  .  . |.. .| .||||  .||.||.||.|.   . .|||||||..|. .    . .|||||| | .||||||.|
eeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrm

VWEQGVVVIVNLTRLSDLGLPQCHRYWPEDGHETY-HIYEVHLVSEhIWCDDYLVRSFYLK-NLQTSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVN
||..   ||| .|.  . |  .| ||||.  ...    ..|. |||    .|| .|.. .. . . .|.|.| |.|| |||| .||. |. .|.| ..||
vwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvse.ksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvn

KCFRGRS----CPIVVHCSGGVGRTGCYILIDLVLNKMMRGA--KEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAEEV
.  .  .     ||||||| |.|||| .|.||..|.....     .|||  .|. .|.||  .|.|..|. |  .|... .
rkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi
0037934 (Phosphotyrosine protein) phosphatases II 208-442 1e-73 243.2 In-house 9-239 (243) alignment 
Range on Protein: 208-442
Range on HMM: 9-239/243.0
KNVRKNRYSDVLPYDHNRVSLretanaTGSDYINASFITDHdPRnpaYIATQGPLAHTVSD----FWQMVWEQGVVVIVNLTRLSDLGLPQCHRYWPeDG
 |. ||||||.|||||.|| |       |||||||..|.   ||   .||||||| .|| |    ||.|.||.|. |||.||.| .||  .|..||| ..
enlsknrysdilpydhsrvkl......egsdyinanliyvt.pr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.ge

HeTYHIYEVHLVSEHIwCDDYLVRSFYLKNLQ-TSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNKC--------FRGRSCPIVVHCSGGVGRTGCY
. ||. ..|.|.||.  .||| || ..|.||. . .||.|...|.|.||| .||..|..||.| ..|...         . .. |..||||.||||||..
v.tygdftvtllseeh.lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtl

ILIDLVLNKMmrgakEIDIAATVEHLRDQRPH-MVKTKAQFEFALTAVA
|...|.| ..     ..|.  .|..||.|||. .| |  |..|   |..
iaaylmllll.....gvdleeavkllreqRpgkavqtpsqyrflyeall
subfamily_PTPN3_pd Subfamily PTPN3 201-442 1.8e-72 238.6 In-house 33-272 (280) alignment 
Range on Protein: 201-442
Range on HMM: 33-272/280.0
ADLGKQDKNVRKNRYSDVLPYDHNRVSLRETANatgsDYINASFITDHDPR---NPAYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTRLSDLGLPQCHR
 .  .. .|. |||| |.||||. ||.|.|. .    |||||...    |       |||||||||.|..||||||||| . .|| || | . |  .||.
isaarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChq

YWPEDGHE-TYHIYEVHLVSEhIWCDDYLVRSFYLKNLQTSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNKCFRGRSCPIVVHCSGGVGRTGCYIL
|||| ..| .|  ..|.. .|      |..| ..||. .|.| |...|. .|.||| .||. .. .||| ..|.|. .|.. |.|||||.|.|||| .||
yWPetedeleygefsvkceke.detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlil

IDLVLNkMMRGAKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVA
... |  ..  |... . . | ..||||  .|.|..|..|   |. 
letala.lieaaepvypldivrtmrdqramlvqtasqykfvCeail
subfamily_PTPRG_pd Subfamily PTPRG 177-446 4.1e-72 238.2 In-house 14-288 (563) alignment 
Range on Protein: 177-446
Range on HMM: 14-288/563.0
HLSNKNRLNKEWEALCNYEAEP-SVADLGKQDKNVRKNRYSDVLPYDHNRVSLRETANATGS-DYINASFITDHDpRNPAYIATQGPLAHTVSDFWQMVW
| ... ....|.||| .  ..    |.  .. .| |||||.....||. ||.|.....  .. |||||..|  .  .. |.|||||||..|. |||.|.|
hadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyq.kskafiatqgplkdtfddFWrmiW

EQGVVVIVNLTRLSDLGLPQCHRYWPEDGHETYHIYEVHLVSEHIWCDdYLVRSFYLKNLQT------SETRTVTQFHFLSWPDLNVPTTPKPLLEFRRK
|| | .|| .| | . |  .|..|||.|. |||   .| |..|.. .  | ||.. .|||.        . ..|.|.|. .||| .||. . | | | .|
eqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlal.ytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkk

VNKCFRGRSCPIVVHCSGGVGRTGCYILIDLVLNKmMRGAKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAEEVN
 ..  .    ||||||| |||||| || .| .|.. ..  . ...  .. |.| ||...|.|. |. |   |. | ..
ssaankaeaGPivvHcsaGvgrtGtyivldtllkq.iqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaia
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 203-447 7.3e-72 236.6 In-house 3-244 (250) alignment 
Range on Protein: 203-447
Range on HMM: 3-244/250.0
LGKQDKNVRKNRYSDVLPYDHNRVSLRETANATGSDYINASFITDHDPRnPAYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTRLSDLGLPqCHRYWPED
..|. .|  ||||.|....|. || | ..     ||||||||.  .| |  |.||||||| .|. |||.||.|. . .|| || |.. .   .|.||| .
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve

GHETYHIYEVHLVSEHIWCdDYLVRSFYLKNLQTSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNKCFRG-RSCPIVVHCSGGVGRTGCYILIDLVL
. |.|    |.| |....  || .| . | . . .. |.| |.||..|||  || . .  ||...||..  .   . |..|.|| ||||.|..| || ||
kaekyGdvtvsllskeefa.dytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavl

NKMMRgAKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAEEVNA
... .  | .|.   .. || .|||.|....|. |  ... . ...
erlkk.ekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 163-444 2e-71 235.9 In-house 15-290 (319) alignment 
Range on Protein: 163-444
Range on HMM: 15-290/319.0
DISTGHVVLSYMEDHLSNKNRLNKEWEALCNYEAEPSVADLGKQDKNVRKNRYSDVLPYDHNRVSLRETANATGSDYINASFITDHDPRNpAYIATQGPL
|. . .  ||  .|   ....|. |. ..|.  .. .  .    |.|  |||. ..|..|.|.| |. .    .||||||||.| .  ..  |||.||||
dfpayyqqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkd.kyiaaqGPl

AHTVSDFWQMVWEQGVVVIVNLTrlsdlgLPQCHRYWPEDGHETYHIYEVHLVSEHiWCDDYLVRSFYLKN-LQTSETRTVTQFHFLSWPDLNVPTTPKP
  |. |||.|.||. .  || ||        .| .||| .. ...  ..|.. | .  ...| ||.. | .  .  . | .|||||| |||  ||  | .
dntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsve.etaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsd

LLEFRRKVNKCFR--GRSCPIVVHCSGGVGRTGCYILIDLVLNkMMRGAKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAEE
|. . .||..  .      .|||||| |||||| || .| .|. .|.  | .|.  .|. ||.||...|.  .|. |  .|. ||
lmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlld.rmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysallee
subfamily_Ptp69D_pd Subfamily Ptp69D 172-444 2.3e-71 235.4 In-house 12-285 (307) alignment 
Range on Protein: 172-444
Range on HMM: 12-285/307.0
SYMEDHLSNKNRLNKEWEALCNYeAEPSVADLGKQDKNVRKNRYSDVLPYDHNRVSLRETANATGSDYINASFITDHDPRNpAYIATQGPLAHTVSDFWQ
..   .   .  | ||.| | .    .  .  .... |  |||| |. ..|..|| |...     |||||||||  .. ..  .|| |.|.  |. |||.
alksrkrdtdfglakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekk.kfiaaqdPveatigDfWR

MVWEQGVVVIVNLTRLSDLGLPQCHRYWPEDGHETYHIYEVHLVSEHIwCDDYLVRSFYLKNLQ-----TSETRTVTQFHFLSWPDLNVPTTPKPLLEFR
|..|| | .|| |. |..    .|..|||..    |    |.||||.  ..||  |.... . .       ..| |.|.|...|.| .|| ... ||.. 
miaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseek.hsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllkli

RKVNKCFRGRSCPIVVHCSGGVGRTGCYILIDLVLNKMmRGAKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAEE
..|..  .    ||||||| ||||.| .. .|..|... .  ...|| .|| .|| ||. .|.  .|..|   |... 
eqvrelyklnrsPivvhCsaGvgrsgifvaldsllqql.kaedkvdifetvkdLrsqRnllvqsleqYvflyralldy
subfamily_PTPRK_pd Subfamily PTPRK 192-443 9.8e-71 233.1 In-house 26-275 (314) alignment 
Range on Protein: 192-443
Range on HMM: 26-275/314.0
CNYEAEPSVADLGKQDKNVRKNRYSDVLPYDHNRVSLRETANATGSDYINASFItDHDPRNPAYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTRLSDLG
 .||. .   |  |.|.| .|||. |.|.||. || |  . . . ||||||..| |   |  |.|.||||| .|| |||..|....   || || | . |
eeyeslfegwdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaali.dsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevg

LPQCHRYWPEDGHEtYHIYEVHLVSEHIWCdDYLVRSFYLKN--LQTSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNKCFRGRSCPIVVHCSGGVG
  .| .|||||..  |   .|.||. .. . ...|| | ...   . .|.|.| ||.||.||| .||.  . ||.. |.|.|    .  .|||||| | |
rvkClkyWPedtev.ygdikvelvetella.elvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaG

RTGCYILIDLVLNkMMRGAKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAE
|||..| || ||. |..  . .|.  .|  ||.... ||.|. |. |   .. |
rtGtfiaidivld.mieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_PTPN9_pd Subfamily PTPN9 181-443 2.3e-69 228.7 In-house 15-288 (297) alignment 
Range on Protein: 181-443
Range on HMM: 15-288/297.0
KNRLNKEWEALCNYEAEpSVADLGKQDKNVRKNRYSDVLPYDHNRVSLRETANATGSDYINASFITDHDpRNPAYIATQGPLAHTVSDFWQMVWEQGVVV
|. | ||.... | ..|   ..  |.  |..||||.||| ||. || | .. . . ||||||.|.  .  .. |.||||||| .||||||.||||| |.|
krGlskeyaeirnepve.GtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGyk.qkkafiatqGplkktvsdfWrmvWeqevlv

IVNLTRLSDLGLPQCHRYWP--EDGHETYHIYEVHLVSEHIwCDDYLVRSFYLKNLQTSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNK-------
||  ||. . |  .| .|||  |.  . .  ..|. |. .   .|| ||.. .|| .|.|.|.|| | ||||||  || . . ||....|| .       
ivmttrvvergrlkcgqyWpleeessaefgdlsvsnvevee.eedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavk

------CFRGRSCPIVVHCSGGVGRTGCYILIDLVLNKMmRGAKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAE
       .. .  ||||||| |.|||| .| .|. |... .    .|.  ||..|| || ....|  |.||   || |
elgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrl.eevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 187-444 1.6e-68 226.3 In-house 3-254 (284) alignment 
Range on Protein: 187-444
Range on HMM: 3-254/284.0
EWEALCNYEAEPSVADLGKQDKNVRKNRYSDVLPYDHNRVSLRETANATGSDYINASFITDHDPRNpAYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTr
|. ..|.  .. .       |.|  |||. ..|..|.|.| |. .    .|||||||||| .  ..  ||||||||  |. |||.|.||. .  || || 
efrracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkd.kyiatqGPldntladfWrmiweyncstivllt.

lsdlgLPQCHRYWPEDGHETYHIYEVHLVSEHiWCDDYLVRSFYLKN-LQTSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNKCFR--GRSCPIVVH
       .| .||| .. .... ..|.. | .  ...| ||.. | .  .  . |...||||| |||  ||  | .|. . .||..  .      .||||
.....kdkcsqywplkivikeerfkvkvdsve.eseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvh

CSGGVGRTGCYILIDLVLNkMMRGAKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAEE
|| |||||| || .| .|. .|.  | .|.  .|. ||.||...|.  .|. |  .|. ||
csagvgrtgvyivldvlld.rmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysallee
subfamily_PTPN23_pd Subfamily PTPN23 174-450 7e-68 223.5 In-house 7-285 (288) alignment 
Range on Protein: 174-450
Range on HMM: 7-285/288.0
MEDHLSNKNRLNKEWEALCNYEAE-PSVADLGKQDKNVRKNRYSDVLPYDHNRVSLRetanATGSDYINASFITDHDPRNPAYIATQGPLAHTVSDFWQM
 .  |..|  |.|... | .....      .    ... |||. |.|||||||| ||     .  |||||||. |  |  | .||||.||. |..|||.|
qrkmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlm

VWEQGVVVIVNLTRLSDLGLPQCHRYWPEDGHETYHIYEVHLV-SEHIWCDDYLVRSFYLKNLQTSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNK
|.|| . ||| |.  ..|| |...||||||  || .  ....  ...   . .  | . |. |.......|.  .. |||.| || .|. ||.|  .|..
vyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldeves

CFR----GRSCPIVVHCSGGVGRTGCYILIDLVLNKMMRGAKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAEEVNAILQ
...        |.||||| |||||| . |.  ..... .|   .||   |..|| || .||..|.|..|.. || |... .|.
ayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvld
subfamily_PTPN13_pd Subfamily PTPN13 182-443 8.3e-68 223.6 In-house 11-267 (273) alignment 
Range on Protein: 182-443
Range on HMM: 11-267/273.0
NRLNKEWEALCNYEAEPSvADLGKQDKNVRKNRYSDVLPYDHNRVSLRETANatgsdYINASFITD-HDPRNPAYIATQGPLAHTVSDFWQMVWEQGVVV
.  ..|.. | .  .  . .. ||...| .|||| .|||||. || | . ..     |||||.|    .  .  |||.|||| .||.||||||||| . |
qqPaeefkelrelkpldt.cevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaev

IVNLTRLSDLGLPQCHRYWPEDGHETYHIYE---VHLVsEHIWCDDYLVRSFYLKNLQTSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNKCFRgRS
|. .|   . |  .|||||||  ...  ...   |.|. .    |.. ||.. .|.....|.| |....| .||| .||.....||.| ..|..  .  .
iamvtlekekgkvkchrywPesknkklkvsnrlevell.kvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.da

CPIVVHCSGGVGRTGCYILIDLVLNKMMRGaKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAE
 ||||||| |.||.| .| || ||. . |  ||.|.  .|..||.||  .|.|| |. |   |. |
gPivvhcsaGiGrsGtlitidvvlglierd.kefdvkeivrklreqrqgvvqtkdqyifvykaile
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 171-447 3.3e-67 221.8 In-house 11-285 (305) alignment 
Range on Protein: 171-447
Range on HMM: 11-285/305.0
LSYMEDHLSNKNRLNKEWEALCNYeaePSVADLGKQDKNVRKNRYSDVLPYDHNRVSLRETANATGSDYINASFITDHDPRNpAYIATQGPLAHTVSDFW
   .|..  ... |......|..    ..  |.||...|..|||.... ..|..|. |.|. .   |||||||..  .. .. .||..|||| .||.|||
ayikearvysdkgleaqykslyee...eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkk.kyivaqgPlkntvadfW

QMVWEQGVVVIVNLTRLSDLGLPQCHRYWPEDGHE--TYHIYEVHLVSEHIwCDDYLVRSFYLKN-LQTSETRTVTQFHFLSWPDLNVPTTPKPLLEFRR
....|  |..|| ||.| . |  .|..||||   |   .  ..|.| ||.    ||. | . . .  . .|.|||.|... .|||  ||...  ||.. .
rliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksekt.asdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslik

KVNKCFR-GRSCPIVVHCSGGVGRTGCYILIDLVLNKMMRgAKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAEEVNA
.|.|  . ..  |..|||| |||||| .| .|. |... .  ...|..  . .|| .|. ||.|..|. |   |..|....
rvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkk.EevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitc
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 208-445 4.9e-63 207.8 In-house 27-268 (274) alignment 
Range on Protein: 208-445
Range on HMM: 27-268/274.0
KNVRKNRYSDVLPYDHNRVSL-RETANATGSDYINASFITDHDPRNPAYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTRLSDLGLPQCHRYWPEDGH--
.. .|||| ..|| .. ||.| .|....  |.|||| .|   | .. ||.||||||..||.|||.|.... | ||| ||.|..    .|..|.|.. .  
gsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedye

--ETYHIYEVHlVSEHIWCDDYLVRSFYLKNLQTseTRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNKCFR---GRSCPIVVHCSGGVGRTGCYILIDL
  |.|   |.. |.. . ..|| ||...||.|.   .|.|. . . .||| ..|  ...||.. ..|..  .    .  |.||||| |.|||||.| |..
iserygdveik.vekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisi

VLNKmMRGAKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAEEV
 ... .|  . .|.  .| .|| .|  ||.|. |.|.   |... .
avrq.lreeivvdvlkivcnlrldrGGmvqtseqyelihralclyl
subfamily_PTPN1_pd Subfamily PTPN1 190-449 6.3e-63 207.2 In-house 10-275 (290) alignment 
Range on Protein: 190-449
Range on HMM: 10-275/290.0
AL---CNYEAEPSVADLGKQDKNVRKNRYSDVLPYDHNRVSLRETANatgsDYINASFItDHDPRNPAYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTR
..   .. ||.   .   |...|  .||| || |||| |. |... |    ||||||.. . .  .  || |||||..||. ||||||||    .| | .
eiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslv.eleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnk

LSDLGLPQCHRYWPEDGHET-YH----IYEVHLVSEHIwCDDYLVRSFYLKNLQTSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNK--CFRGRSCP
. . .  .|..|||.. .|         ..|.|.||..  . | || . |.||.| |||....||...|||. || .|  .|.|  || .  ..     |
vvekeqikcaqywPqgeeekellledtklkvkliseer.ksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGp

IVVHCSGGVGRTGCYILIDLVLNKMMRGAK--EIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAEEVNAIL
 |.||| |.||.| ..|.| .| .. .  .   .||  .. .|| .|  ...|. |..|. .|. | .. | 
avihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvik
subfamily_PTPN14_pd Subfamily PTPN14 181-442 4.2e-62 204.8 In-house 22-293 (300) alignment 
Range on Protein: 181-442
Range on HMM: 22-293/300.0
KNRLNKEWEALCNYEAePSVADLGKQDKNVRKNRYSDVLPYDHNRVSLRETANAtGSDYINASFITDH-DPRNPAYIATQGPLAHTVSDFWQMVWEQGVV
. .. .|.| . . ..  .. . .| ..|..|||. |||||..||| |  | ..  ..||||| |      ..  ||..|||| .|| ||||||||||| 
egkvfteyeripkkre.dallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvq

VIVNLTRLSDLGLPQCHRYWPEDGHETYHI-YEVHLVSEHIW--CDDYLVRSFYLKNLQTSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVN------
.|| ||.  . |  ....|.|.....  .. .. . |...     | .  ... || | ..| |||  . .  ||| .||  .|. |.. ..|.      
livmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrkt

-KCF--RGRSCPIVVHCSGGVGRTGCYILIDLVLNKMmRGAKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVA
 .    . .. |..|||| ||||||  || ||... .    .||||  ....|| || ..|.| ||..|  ... 
nseveskeskPPvlvhCsaGvGrtGvlilsdlliatl.ehneeidikkvlarLreqrmllvqtlaqYkfvYkvli
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 189-445 6.7e-62 204.3 In-house 31-284 (297) alignment 
Range on Protein: 189-445
Range on HMM: 31-284/297.0
EALCNYEAEPSVADLGKQDKNVRKNRYSDVLPYDHNRVSLRETANATGSDYINASFITDHDPrnpAYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTRLS
| ||  ||.   .   ..  |  |.||...|||| .|| |. . .   |||.||||.         .|.|| |   || |||.||... | .|| |. ..
eflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvstivmlnddn

DLGLpQCHRYWPEDGHETYHIYEVHLVSEHiWCDDYLVRSFYLKNLQTSETRTVTQFHFLSWPDLNVPT--TPKPLLEFRRKVNKCFRGRSC-PIVVHCS
.    .| |||...|  |.    | | | .  .  .. |.. ... ..  .| | |..|..||| .|.   . . ||..   |.| | ...  |..|||.
erdk.kcaryWsdkgvttfGdvsvvllsvs.ereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhcl

GGVGRTGCYILIDLVLNKMMRgAKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAEEV
 |||||| .. || |. .. |  ||.||  .|..||..||..|.|| |..|   || | .
aGvGrtgvlltidsvvaeakr.ekevdifglvkklrqerpylvqtkeqykfvyvavleal
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 175-443 7e-61 200.9 In-house 17-277 (315) alignment 
Range on Protein: 175-443
Range on HMM: 17-277/315.0
EDHLSNKNRLNKEWEALCNYEAEPsvADLGKQDKNVRKNRYSDVLPYDHNRVSLRETANATGSDYINASFITDHDpRNPAYIATQGPLAHTVSDFWQMVW
. . | || .....|..   .  |   |  |. .|..|||| ....||. || |  . |  .|||.||.||  .. ..  |||.|||.. .| |||..|.
qkkastkngfkqdyesipggqlhp..ldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGyn.kkrryiaaqgpnvasvkdfwrlvf

EQGVVVIVNLTRLSDLGLPQCHRYWPEDgHETYHIYEVHLVSEHIWcDDYLVRSFylKNLQTSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNKCFR
|. .  || || | .    .. .|||.. . .|  . | ..|| .  ..| ||..       .. |.| |.|. |||| .||    ||... |.|..   
eedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevn.teytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhht

GRSCPIVVHCSGGVGRTGCYILIDLVLNKMmRGAKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAE
   ..|||||| |||||| .| .| ||...    . ||.   .. .|..| .||.. .|..|   |. |
nsvgaivvhcsaGvGrtGtfitldavldqa.eaenaidvynfitgvrqnrikmvqvaeqyqfiydalle
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 205-445 3.8e-60 198.4 In-house 39-276 (515) alignment 
Range on Protein: 205-445
Range on HMM: 39-276/515.0
KQDKNVRKNRYSDVLPYDHNRVSLRETANATGSDYINASFITDHDPrNPAYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTRLSDLGLPQCHRYWPEDG-
... | .|||| ..|||| .|| |    ..  |||.|||.|   |  . ||||.|||.  .|.|||..|... |  |. .|.|..    .| .|||.   
qeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdn.dkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpg

-HETYHIYEVHLVSEHIwCDDYLVRSfyLKNLQTSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNKCFRGRSCPIVVHCSGGVGRTGCYILIDLVLN
    .  ..|.||| .  | . . |   |. |. ...||||||||  |||  ||   . || . ..|       . |...||| |||||| .| || |. 
dsvkfGsikvelvslea.ctggikrk..ltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvva

KMMRgAKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAEEV
..   .. .|.  .|. .|..||..|.|. |. |   || |..
hakt.trmvdvfnfvtnirqkrpylvqtqeqyafiygavledl
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 175-446 5.3e-60 197.7 In-house 13-284 (290) alignment 
Range on Protein: 175-446
Range on HMM: 13-284/290.0
EDHLSNKNRLNKEWEALCNYEAEPSVAdLGKQDKNVRKNRYSDVLPYDHNRVSLRETANAT--GSDYINASFITDHDPrNPAYIATQGPLAHTVSDFWQM
..|  .... ......| . | | .|   |   .| ..||......|| ||. ||. ..      .||||..| ..   . .|||||||. .|. |||..
nghakgnegfrnqfkmldsgesehtvt.vgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgyke.kkqyiatqgpvsntlvdFWkl

VWEQGVVVIVNLTRLSDLGLPQCHRYWPEDGHETYHIYEVHLVSEHIWCdDYLVRSFYLKNLQT-SETRTVTQFHFLSWPDLN-VPTTPKPLLEFRRKVN
.|.. | .|| ||   . |  .|. |||. . ..|  ....|..|..   .|  | . .|| ..  ....|||... .|..   |. .   || ... ..
iwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetln.eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyk

KCFRGRSCPIVVHCSGGVGRTGCYILIDLVLNKMMRgAKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAEEVN
. ..    .||||||..|||.. .. ..  .||.      ||. . ....| |.| .|.|. |...  . | . ..
tqrkrgntsivvHCSdtvgrsavfcaaattinkckt.egvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 197-446 1.8e-59 196.1 In-house 32-278 (315) alignment 
Range on Protein: 197-446
Range on HMM: 32-278/315.0
EPSVADLGKQDKNVRKNRYSDVLPYDHNRVSLRETANATGSDYINASFITDHDPrNPAYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTRLSDLGLPQCH
...    .... | .|||| ..||.|..|| |    .   |||||||.|   |  . ||||.||||  .|.|||.||... |  || .| ...    .| 
diyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdd.dkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcr

RYWPE--DGHETYHIYEVHLVSEHiWCDDYLVRSFYLKNlqTSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNKCFRGRSCPIVVHCSGGVGRTGCY
.|||.       .  ..|.|.| .  . |  .| . ...  . |.||||||.|  |||  |.     ||.. ..|    . .  ...|||| ||||||  
qywPdrkadsvefGsikvellsle.adtdgvarklvtrk..seesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvv

ILIDLVLNKMMRGaKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAEEVN
| || |.... |. . .|.  .|. ||..||..|.|. .. |   || |.. 
isidevvaqikrt.rsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 205-443 4.1e-59 194.6 In-house 3-238 (239) alignment 
Range on Protein: 205-443
Range on HMM: 3-238/239.0
KQDKNVRKNRYSDVLPYDHNRVSLRETANATGSDYINASFITDHDPRNPAYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTRLSDLGLPQCHRYWPeDGH
|.  |  ||||.... |||.|| | . .|   |||||||.. |.|    ||||||| .. .  |||.|.|..  .||| || | .    .||.||| |  
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.dst

ETYHIYEVHLVSEHIWCdDYLVRSFYLKNLQTSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNKCFRGRSCPIVVHCSGGVGRTGCYILIDLVLNKM
  |    | |    ... ||..|.| . ..  .| | | |.||  |||  ||     .| .|||. |     . | |.||| ||||||....|| .| . 
skycnlrvtlrktevfa.dyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

mRGAKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAE
 .  | .||   |. .|..|||||.|  |. |   || |
.kkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 205-442 4.8e-59 194.4 In-house 4-238 (239) alignment 
Range on Protein: 205-442
Range on HMM: 4-238/239.0
KQDKNVRKNRYSDVLPYDHNRVSLRETANATGSDYINASFITDHDPRNPAYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTRLSDLGLPQCHRYWPeDGH
|.  |  ||||.... |||.|| | . .|   |||||||.. |.|    ||||||| .. .  |||.|.|..  .||| || | .    .||.||| |  
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.dst

ETYHIYEVHLVSEHIWCdDYLVRSFYLKNLQTSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNKCFRGRSCPIVVHCSGGVGRTGCYILIDLVLNKM
  |    | |    ... ||..|.| . ..  .| | | |.||  |||  ||     .| .|||. |     . | |.||| ||||||....|| .| . 
skycnlrvtlrktevfa.dyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

mRGAKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVA
 .  | .||   |. .|..|||||.|  |. |   || 
.kkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 201-445 5.6e-59 194.9 In-house 40-288 (325) alignment 
Range on Protein: 201-445
Range on HMM: 40-288/325.0
ADLGKQDKNVRKNRYSDVLPYDHNRVSLRETANATGSDYINASFITDHDpRNPAYIATQGPLAHTVSDFWQMV--WEQGVVVIVNLTrlsDLGLPQCHRY
     . .|. |||. .|...|..|| |    ... |||||||.. |.  .   ..|.| ||..|. |.|..|  |.  |||..|     |||  .|  |
kkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddk.kkdvflaaqaPltatindlWrlvldWrcsvvvvlnel...dlgkdrcavy

WPED--GHETYHIYEVHLVSEHIWcDDYLVRSFYLKNLQTSETRTVTQFHFLSWPDLNVPTTPKPLLEFR---RKVNKCFRG---RSCPIVVHCSGGVGR
||..     |.   ||.|..      ||. | . .|. .  |||.| ||.. ||.|. |.  |  |. .     .|... .     | ||.|||| ||||
wpkemgksktfGglevklrtieei.sdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGr

TGCYILIDLVLNKMMRGAkEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAEEV
|| .| .  .|.|..  . ..||   |..|| .|| ||.|  |. .  .|..| .
tGvfislysalakviees.rvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 178-442 1.2e-58 193.2 In-house 6-274 (287) alignment 
Range on Protein: 178-442
Range on HMM: 6-274/287.0
LSNKNRLNKEWEALCNY-EAEPSVADLGKQDKNVRKNRYSDVLPYDHNRVSLRETANaTGSDYINASFITDHDpRNPAYIATQGPLAHTVSDFWQMVWEQ
.  |. ..|| .||..  |. . .    ..  .|.||||.||||.|..|| | ....  ||||||| ... .  .. |.||.|||.| || |||..|.|.
rrvkddvdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsaege.lGsdyinanyvasyt.ddeafiaaqgPiaatvrdfwravlet

GVVVIVNLTRLSDLGLPQCHRYWPEDgHETYHI--YEVHLVSEHIWCDDYLVRSFYLKNLQTSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNKC--
 . ... .||  . .  .|..||||  .    .  | | |..  |   .| ||.. | .|.| |.| | |...|||||  .. |   |. |  .|..   
rsasvitmtreveearlkcykywPer.evPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhie

-FR--GRSCPIVVHCSGGVGRTGCYiLIDLVLNKMMRGAKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVA
  |      |.|||.. |.||.| . |  ||| ...    ..|.||.| .|| .|  .|..  |. .   |..
lardasevGPlvvhddvGiGrsGil.latlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 208-439 4.7e-57 187.9 In-house 2-233 (237) alignment 
Range on Protein: 208-439
Range on HMM: 2-233/237.0
KNVRKNRYSDVLPYDHNRVSLRETANAtgSDYINASFITDHDPRNPAYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTRLSDLGLPQCHRYWPE-DGHET
.|  ||||...  |||.|| |. . ..  ||||||... . |     |||.||||  .  |||||||..   ||| || | .    .||.|||. |  ..
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YHIYEVHLVSEHIWCdDYLVRSFYL-KNLQTSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVN-KCFR-GRSCPIVVHCSGGVGRTGCYILIDLVLNK
| .. | |  .  .. || |||. | |.|.  | | . |..| ||||  ||     || ||...  .     .|.| ..||| |||||| ...|| .| .
ygvltvslkkkeefs.dytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrq

mMRGAKEIDIAATVEHLRDQRPHMVKTKAQFEFALT
  .  | .||   |  . ..||....|| |. |   
.akekkvvdiynyvysieedrpyiiqtkdqyvfihq
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 175-447 1.7e-56 186.3 In-house 13-280 (287) alignment 
Range on Protein: 175-447
Range on HMM: 13-280/287.0
EDHLSNKNRLNKEWEALCNYEAEPSVADLGKQDKNVRKNRYSDVLPYDHNRVSLRetanATGSDYINASFITDHDpRNPAYIATQGPLAHTVSDFWQMVW
..|  ...  .. .  | . . ..     .   .|  |||....|..| .|| |.     .  |||||.||  .   . |.|....|...|. .||....
kghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgyk.ekkafiiaesPmfntarnfWklid

EQGVVVIVNLTRLSDLGLPQCHRYWPEDGHETYHIYEVHLVSEHiWCDDYLVRSFYLKNLQ-TSETRTVTQFHFLSWPDLN-VPTTPKPLLEFRRKVNKC
.. | .|| |... .    .|..||||.   ..  |...|..|.   ..|..| . .|| . ......|.|... .|..   |..    || . ... . 
drnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellnee.vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktq

FRGRSCPIVVHCSGGVGRTGCYILIDLVLNKMMRGaKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAEEVNA
 .    .|||||| .|||.. .. ..  .||  .    ||.   ... | |.|..|.| .|..|   .| | ...
rkrgntsivvhCsdtvGrsamfcaaattinkckte.GviDvfqvlksqriqkpgsvqtveqykfindivleylds
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 199-447 7.2e-55 180.9 In-house 10-266 (270) alignment 
Range on Protein: 199-447
Range on HMM: 10-266/270.0
SVADLGKQDKNVRKNRYSDVLPYDHNRVSLRETANATGSDYINASFITDHDPRNPAYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTRLSDLGLPQCHRY
|  || .. .. . ||| |.||  . || | |  .   . |||| ..   | .. .|||..|||. |...||.|.||. |  || .| | . |  .| ||
sesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerY

WPEDGHE--TYHIYEVHLVSEH-IWCDDYLVRSFYLKnlQTSETRTVTQFHFLSWPDLNVPTTPK------PLLEFRRKVNKCFRG--RSCPIVVHCSGG
||.. .|  ...  ... ....    . |...   |.  ...|.| .. |.. .|||  ||...        ||.  |.| .  .   .. |..|||| |
Wpaepkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaG

VGRTGCYILIDLVLNkMMRGAKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAEEVNA
|||||. |..| ... ..   |..|..| .|.|| .|. .|..  |.||.  ||.| .. 
vgRtGtlialDiavr.lLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 185-445 1.6e-53 176.8 In-house 23-279 (439) alignment 
Range on Protein: 185-445
Range on HMM: 23-279/439.0
NKEWEALCNYEAE-PSVADLGKQDKNVRKNRYSDVLPYDHNRVSLRETANATGSDYINASFITDH-DPRnpAYIATQGPLAHTVSDFWQMVWEQGVVVIV
....| .   . .   .| |  |. .  |||| || ..|| || |.|.     | |||| .|  . |..   |||||||  .|. |||..|.|. .| ||
keifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddk..lyiatqgpkkettddfwrlviekktvtiv

NLTRLSDlglpqCHRYWPEDGHETYHIYEVHlVSEHIWCDDYLVRSFYLKN--LQTSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNKCFRGRS-CP
.|| | .      ..||| |..  |    |. |   |   .| .| | . |   .|   ||| |||...||| |||.    .|.| | .| .   .   |
mltnlve.....sykywpsdaevcygdiavr.vdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygp

IVVHCSGGVGRTGCYILIDLVLNKMmRGAKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAEEV
.||||| ||||||  | .|. |... .  ...||   |. ||.|| .||.. .|. |   || |..
vvvhcsagvGrtGtiialdialeql.klenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
subfamily_CG7180_pd Subfamily CG7180 204-444 9.6e-52 170.4 In-house 37-289 (296) alignment 
Range on Protein: 204-444
Range on HMM: 37-289/296.0
GKQDKNVRKNRYSDVLPYDHNRVSLRETANATGSDYINASFITDHdPRNPAYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTRLSDLGLpQCHRYWPEDG
| . .|  |||. .|.|||.||| |..      ||||||...  .  .. .|| |..|  .|| .||..|.....  .|.||.  |    ... |||...
glrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsf.lkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks

HETYHIYEVHLVSEHIWCDdYLVRSFYLKNL----------QTSETRTVTQFHFLSWPD-LNVPTTPKPLLEFRRKVNKcFRGRS------CPIVVHCSG
.| |   .|..|.|. . .    | | |.             . |||.|..|..  |.   .||   . |.|.||.|.. .|..        |.||..| 
keqygeifveiveekqyan.lkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrl.wrekvdedpeegPvvvvssd

GVGRTGCYILIDLVLNKMMRgAKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAEE
|..|.| |. ||  |... .  .|.|.   |  || .||..| .. .. .    . | 
GasRsGvylaidanlelvek.eeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 201-445 4.7e-51 168.4 In-house 37-236 (392) alignment 
Range on Protein: 201-445
Range on HMM: 37-236/392.0
ADLGKQDKNVRKNRYSDVLPYDHNRVSLRETANATGSDYINASFITDHDPrNPAYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTRLSDLGlpqchrywp
   .... |..|||| ..|||| .|| |    . . |||.|||.|   |  . ||||.||| | ...|||.||... |  |. .|.| .           
qtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdn.ekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.........

edghetyhiyevhlvsehiwcddylvrsfylknlQTSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNKCFRGRSCPIVVHCSGGVGRTGCYILIDLV
                                  .  ..|||.||||  ||| .||     ||.| ..|.  |   . |...||| ||||||  | || |
..................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsv

LNKMmRGAKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAEEV
. .  . .. .|.   |  .| .||.||.|| |. |   || |..
vaha.kktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledl
0041856 (Phosphotyrosine protein) phosphatases II 209-443 2e-50 166.2 In-house 1-169 (182) alignment 
Range on Protein: 209-443
Range on HMM: 1-169/182.0
NVRKNRYSDVLPYDHNRvslretanatGSDYINASFITDHDPRNPaYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTrlsdlglpqCHRYWPedghetyh
|. ||||||.|||||.|          ..|||||...    | .  .||||||| .|| ||..|..|.|. .|||||         ...|||        
nldknrysdilpydhsr..........dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywp........

iyevhlvsehiwcddylvrsfylknlqTSETRTVTQFHFLSWPDLNVPTtPKPLLEFRRKVNKcfrgRSCPIVVHCSGGVGRTGCYILIDLVLNKmmrga
                           . ..|...|...|.||| .||. .  ||.| ..|..    ...|..||||.||||||......|.. .     
...........................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....

kEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAE
 ....  .|...| .||.|| |  |. |   |. |
.gvsleeavklvrsrRpgmvitpnqyfflqlalle
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 189-444 4.9e-49 161.7 In-house 13-265 (283) alignment 
Range on Protein: 189-444
Range on HMM: 13-265/283.0
EALCNYEAEPSVADLGKQDKNVRKNRYSDVLPYDHNRVSLRETANatgsDYINASFIT--DHDPRNPAYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTR
| | .    .  ||.   |.| ||||. ...|.| .|| |.  ..    |||||.||.  ... ..  ||..|.|| .|| |||.||... .. || ||.
evlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltk

LSDLGLPQCHRYWPEDGHETYHIYEVHLVSEhIWCDDYLVRSFYLKNL-QTSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNKCFRGRSCPIVVHCS
| .    .| .|||..| | |  . | |  |    . . .. . |..   . .|  .. . .  | . .  .    |. | . . .  . .  |||||||
lqedlrikCsqyWPkrGsedyGeftvtlrke.ttsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCs

GGVGRTGCYILIDLVLNKMmRGAKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAEE
 |.|||. .| .   .... .    .|. |.|. .| ||. .|.|. |. .  ..| |.
tgiGrtavfiaasasvkda.ltesvvdvfavvkimreqrmmavqtldqyklvhelvleq
0051429 (Phosphotyrosine protein) phosphatases II 237-447 3.1e-47 156.8 In-house 4-227 (272) alignment 
Range on Protein: 237-447
Range on HMM: 4-227/272.0
SDYINASFITDHdPR---NPAYIATQGPLAHTVSDFWQMvWEQGVVVIVNLTRLSDLGLPQCHRYWP------------EDGHETYHIYEVHLVSEHiWC
|.||||...     |     ......||| .|. |||.. .|.|. .||.|.... .|  .|.||||            ..   .|. . | |.||. ..
sgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllsee.ll

DDYLVRSFYLKNL-QTSETRTVTQFHFLSWPDLNVPTTPkpLLEFRRKVNKcfrgrSCPIVVHCSGGVGRTGCYILIDLVLnKMMRGAKEID--------
.||..| ..|..| ...|.|.|...|...||| .||. .  |||. . ...     . |..||||.|..|||......|.|   .     .|        
ldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnly

IAATVEHLRDQRPHMVKTKAQFEFALTAVAEEVNA
....||.||.|||..| | .|..| . |..| ...
leeaveelraqrpgavqteeqylflyeallellrs
0049772 (Phosphotyrosine protein) phosphatases II 207-445 4.7e-43 143.5 In-house 44-280 (314) alignment 
Range on Protein: 207-445
Range on HMM: 44-280/314.0
DKNVRKNRYSDVLPYDhNRVSLrETANATGSDYINASFITDHdprnPAYIATQGPLAHTVSDF----------WQMV--WEQGVVVIVN-----------
 .|  |||| |.||.| ||| |  . .  ||||||||..  .     ..||||||| .|| ||          |.||  ... | .||            
flnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladels

----------LTRLSDLGlpqchRYWPEDGHETYHiyevhlvsehiwC-----DDYlvrsfylknlqtseTRTVTQFHFLSWPDLNVPtTPKPLLEFRRK
          |..|. .|      ....   |...                  ...              .|.. ... . .|| ..| ... ..|| . 
rLdaAlgKtpllildgng.....neptaadlellk............eelydpelf..............erlgikylripvpDgsap.lledfdeflef

VNKCfrGRSCPIVVHCSGGVGRTGCYILIDLVLNKMmrgakEIDIAATVEHLRDQRP-----HMVKTKAQFEFALTAVAEEV
....   .  |..|||..|.||||......... ..      .... ..|..| .||     .....  |.|| | |. | .
ieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll.....gvsleealedvrlkRpinpnpgfieqleqyefilealleyl
0036282 (Phosphotyrosine protein) phosphatases II 236-436 1.2e-42 140.9 In-house 1-161 (174) alignment 
Range on Protein: 236-436
Range on HMM: 1-161/174.0
GSDYINASFITDHDPRNpAYIATQGPLAhtvsdFWQMVWEQGVVVIVNLTRLSDLGLPQCHRYWPEdghetyhiyevhlvsehiwcddylvrsfylknLQ
||||||||..  .   .  .||.|||||     ||.|..|.|. ..|.|...  |||  |..||||                                |.
gsdyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lr

TSETRTVTQFHFLSWPDLNVPTTPKpLLEFRRKVNKCFRG-RSCPIVVHCSGGVGRTGCYILIDLVLNKMMrgAKEIDIAATVEHLRDQRPHMVKTKAQF
....|.. |...| ||| .||.... |||| . |....   ...|..||||.||||||. ....|.|  ..   . .|. ..|  || |||.|| |  |.
edlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqrpgmvqtpsQy

EF
.|
rf
subfamily_ptpA1_pd Subfamily ptpA1 175-413 4.8e-42 139.2 In-house 14-265 (418) alignment 
Range on Protein: 175-413
Range on HMM: 14-265/418.0
EDHLSNKNRLNKEWEaLCNYEAEPSVADLGKQDKNVRKNRYSDVLPYDHNRVSLRETANATGSDYINASFITDHDPRNpaYIATQGPLAHTVSDFWQMVW
..|.    ....|.  | .    || .  | . .|  ||||...|| .| || |..  .  ||||||| .|    |..  .|.|||||  |..|||.|||
knhikcihkikeefr.lleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkq..fictqgplpntiadfwrmvw

EQGVVVIVNLTRLSDLGLPQCHRYWPED-----------GHETYHIYEVHLVsEHIWCDDYLVRSFYLKNLQTSETRTVTQFHFLSWPDLNVPTTPKPLL
|. . .|| |.| |.    .| |||||.           | | .  | | || | |   .  . .  ..     ||| .||...  ||| |.|   .|. 
enrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelv.eviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfr

EFRRK----VNKC--FRGRSCPIVVHCSGGVGRTGCYILIDLVLNKMMRGAKEIDI
.. .      |.      |  ||.|||| |||||| .    ....|. .  |..| 
qllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkldhyfkqlda
0043147 (Phosphotyrosine protein) phosphatases II 236-437 5.1e-42 138.8 In-house 4-153 (172) alignment 
Range on Protein: 236-437
Range on HMM: 4-153/172.0
GSDYINASFItDHDPRNPAYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTRLsdlglpqchrywpedghetyhiyevhlvsehiwcddylvrsfylKNLQ
||||||||.. |     . .||||||| .|..|||.|..|.|. .|||||.|                                             .. 
gsdyinasyl.dlyyipdrfiatqgplrntladfwrmlkelgithivnltel............................................lydp

TSETRTVTQFHFLSWPDLNVPtTPKPLLEFRRKVNK-CFRGRSCPIVVHCSGGVGRTGCYILIDLVLnkmmrgaKEIDIAATVEHLRDQRPHMVKTKAQF
. ..|.. |...|.||| .|| ... |||| . ... . . ...|..||||.||||||. ....|.|       . ...  .|...|..||..| .. | 
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.......lglsleeavalvrekRpgavqnpsqy

EFA
 | 
rfl
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 179-439 1e-40 134.3 In-house 12-287 (301) alignment 
Range on Protein: 179-439
Range on HMM: 12-287/301.0
SNKNRLNKEWEALCNYEAEPsvADLGKQDKNVRKNRYSDVLPYDHNRVSLRETAN--ATGSDYINASFITDHDPRNpAYIATQGPLAHTVSDFWQMVWEQ
 ..|........| ..| ..  ...| ...| . ||. .. .||.||. |... |   .  .|||||.| .   .. ..||.|||. .|. |||...|..
khsnkfeeqykelkegedks..ctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekk.kfiaaqgpmkktlvdfWrliwqe

GVVVIVNLTRLSDLGLPQCHRYWPEDGHETYHIYEVH-LVSEHIWCDDYLVRSFYLKNLQTS---------------ETRTVTQFHFLSWPDLNVPTTPK
 .| || .| | .    .|..|||.  .|... .... .....    |...|.. .|  ..|               ....|.|..  .||.  |   |.
kpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvrepr

PLLEF-RRKVNKCFRGRSCPIVVHCSGGVGRTGCYILIDLVLNKMMRgAKEIDIAATVEHLRDQRPHMVKTKAQFEFALT
  |.     . .  .    |.||||| .|.|.| |. ... |    .    .|.   .. .| ..| .|.|  |. .   
tvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQcka.egVVdvfqvtkavrrskpgaVtTLeqytsiyd
0046846 (Phosphotyrosine protein) phosphatases II 234-439 1e-40 134.7 In-house 9-167 (176) alignment 
Range on Protein: 234-439
Range on HMM: 9-167/176.0
ATGSDYINASFITDHdprnpAYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTRLSDLGLPQCHRYWPEdgHETYHIyevhlvsehiwcddylvrsfylkn
  ..|||||..|  .     ..||||||| .|. ||..|..|.|. ..|||| . .||  .|..||||   |...|                        
dldldyinanlilgs.....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi........................

lqtsetrtvtQFHFLSWPDLNVPTTpKPLLEFRRKVNKCFRGRsCPIVVHCSGGVGRTGCYILIDLVLNKmmrgaKEIDIAATVEHLRDQRP-HMVKTKA
          |...| ||| .||.  . |||. . .... .    |..||||.|.||||......|.  .     | ...  .....|.||| ..| | .
..........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllele.....kglsveealalvreqRplgavqtpe

QFEFALT
| .|   
Qyrflye
0049260 (Phosphotyrosine protein) phosphatases II 252-437 3.3e-40 132.6 In-house 8-142 (152) alignment 
Range on Protein: 252-437
Range on HMM: 8-142/152.0
NPAYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTRLSDLGLPQCHRYWpedghetyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtQFHFLSWP
. ..||||||. .|..|||.|..|.|. .||.||.|..|| ..|..|.                                            |...| ||
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................qylhlpwp

DLNVPTTPKPLLEFRRKVNKCFRGRSCPIVVHCSGGVGRTGCYILIDLVLnkmmrgaKEIDIAATVEHLRDQRPHMVKTKAQFEFA
| .||. .  ||.. . ..|. . ...|..||||.||||||......|.|       . ...  .|...| .||..| .. | .| 
DhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnpgqlrfl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 183-435 2.2e-39 130.3 In-house 17-267 (307) alignment 
Range on Protein: 183-435
Range on HMM: 17-267/307.0
RLNKEWEALCNYEAEPSVADlgKQDKNVRKNRYSDVLPYDHNRVSLRetANATGSDYINASFITD-HDPRnpAYIATQGPLAHTVSDFWQMVWEQGVVVI
.|  |.. |.... |   ..    . |  ||||.||   |..|. ..   .   |||| | ..    .|.   .|..||||  |. .|| |. .. |  .
alvdefrvlakktpegvtve..afsantdknryqdvkcqdkgrivvk..fdglasdyihanylgiaikpk..kficaqgplentqysfwamaiqekvesv

VNLTRLSDLGLPQCHRYWPE-DGHETYHIY------EVHLVSEHIWCDDYLVRSFYLKNLQTSETRTVTQFHFLSWPDLNVPTTPKPLLEFRrkvnKCFR
. | .. .|.  .|..|||  .| .  .           | ....  |. |.    ||   ....||.... .  |||  || .    ...     .  |
imlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainll....eavr

GRSCPIVVHCSGGVGRTGCYILIDLVLNKMMRGAKEIDIAATVEHLRDQRPHMVKTKAQFE
.   |.||||| ||||.|  . | || .||..|    |.   || ||.||.. ..|.||. 
ydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqyl
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 207-435 4.5e-38 125.5 In-house 52-273 (290) alignment 
Range on Protein: 207-435
Range on HMM: 52-273/290.0
DKNV--RKNRYSDVLPYDHNRVSLRETANatgSDYINASFITDhdpRNPAYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTRLSDLGLPQCHRYWPEDGH
|||   .|||| ||   |  || |..  .    ||. | ..      .. .| |||.|. || |.|.|| ...| .|| |  | . | ..|..|.||   
dkntefkknrykdvvcndktrvilkdGyd...GdyvhanyvkG...lkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeG

ETYHIYEVHL--VSEHIWCDDYLVRSFYLKNLQTSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVnkcfRGRSCPIVVHCSGGVGRTGCYILIDLVLN
|.  . |. .    |.   ..   . . ... ..     .  ..  ||||  |. .   ||   | .    |  | |.||||| |.|||| .. |.  |.
evltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlril....rkasGpvvvhcsaGiGrtGtfvaievglq

KMMRGaKEIDIAATVEHLRDQRPHMVKTKAQFE
 .. | ||.|.. .|  ||. |   |.   |. 
illdG.keldlldlvralrnsrlnsvqvdiqyl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 194-372 7.3e-38 125.1 In-house 18-196 (297) alignment 
Range on Protein: 194-372
Range on HMM: 18-196/297.0
YEAEPSVADLGKQDKNVRKNRYSDVLPYDHNRVSLRETanATGSDYINASFITDHD-PRNPAYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTRLSDLGL
 ||..      |..  .||||| |.| .| .|| |. .   |..||||| ...  | . .  || .||||  || |||..|.||.| ||| ...| . | 
deargesfssakrnsslrknryrdilatddtrvkllrv..iterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGr

PQCHRYWPEDGHETYHIYEVhlVSEHI--WCDDYL-VRSFYLKNLQTSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNKC
 .|  |||.   |  .  .|  | |..    |..  |    |. .  ||.| |.   ||||||  ||.  . |  |. .|  |
dkcapywpsvvqerlkagdv..vveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcsc
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 181-450 4.7e-37 122.4 In-house 5-264 (267) alignment 
Range on Protein: 181-450
Range on HMM: 5-264/267.0
KNRLNKEWEALCNYEAEPSVADLGKQDKNVRKNRYSDVLPYDHNRVSLRETANAtgsdYINASFITDHDPRNpAYIATQGPLAHTVSDFWQMVWEQGVVV
.  ..||.| . .   . |        ||  .||. |.||||..|| ||.. .     |||||..  .  .| |.|.||.||  |..||.... .|.| |
eceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktkn.afivtqdplkntitdfltvihdqkvpv

IVNLTRLSDLGLPQchrYWPED-G-HETYHIYEVHLVSEHiWCDDYLVRSFYLKNLQtSETRTVTQFHFLSWpdlNVPTTP----KPLLEFRRKvnKCFR
|| ||.     ...   .||   |  . |.   |    |.   .|| . .. ||  .   .. || ...  |   |. |      |||.    |  . . 
ivlltkvftdnirl...fwPPkmgqakkyqdltvehslek.eendyqiitlelkfkn.esahnvtlyyykkw...nintnnkpylkplfgilak..nqle

GRSCPIVVHCSGGVGRTGCYILIDLVLNKMMRgAKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAEEVNAILQ
  . |.||.|| ||||.| .. ||  |... .     ||   . ..|.||. .|.|| .. .    .||  .  |.
ngnrPlvvacsdGvGrsGtflvidsqlerakt.egvsdifdflrkirsqriglvdtkeryiyihellaeyaegrlk
0044763 (Phosphotyrosine protein) phosphatases II 220-436 8e-37 121.9 In-house 1-162 (178) alignment 
Range on Protein: 220-436
Range on HMM: 1-162/178.0
PYDHNRVSLRETANATGSDYINASFITDHdprnpAYIATQGPlahtvSDFWQMVWEQGVVVIVNLTRLSDLGLPQCHRYWPEDGHetyhiyevhlvsehi
|.|..||.| .  .  .|||||||.|...      |.....|     .|......|.|. .|||||    || ..|..||||. .               
pldrtrvllsnleglersdyinaseilpg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...............

wcddylvrsfylknlqtsetrtvTQFHFLSWPDLNVPTTPKPLLEFRRKVNKCFRGRSCPIVVHCSGGVGRTGCYILIDLVLNKmmrgakEIDIAATVEH
                        |.... .|| .||. .. .||| . ....   . .|..|||| ||||.|. ....|..         ... . .|.
.......................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl......glsleeaiel

LRDQRPhMVKTKAQFEF
.| .|| .| .  | ..
vrerRp.ivpnpgqlrq
0051082 (Phosphotyrosine protein) phosphatases II 237-440 9.8e-36 118.0 In-house 3-148 (151) alignment 
Range on Protein: 237-440
Range on HMM: 3-148/151.0
SDYINASFITDHdprnpaYIATQGPLAhtvsDFWQMVWEQGVVVIVNLTRLSDLGlpQCHRYWPEDGhetyhiyevhlvsehiwcddylvrsfylknlqt
|||||.|..|..      .....||||    ||.....|.|. .||||. .   |   |..|.|| |                                 
sdyinfsyvtgg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

setRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNKcfrGRSCPIVVHCSGGVGRTGCYILIDLVLNKmmrgakeIDIAATVEHLRDQRPHMVKTKAQFEF
   ..|.....|.||| ..|.... .||| .....    .. |..||||.|.||||. ....|.| .       .......|..| .||..| .. || |
...ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrpgvvqpnqqflf

ALTA
 | |
qlfa
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 205-434 2.8e-34 113.1 In-house 33-258 (281) alignment 
Range on Protein: 205-434
Range on HMM: 33-258/281.0
KQDKNVRKNRYSDVLPYDHNRVSLRE-TANATGSDYINASFITDHDpRNPAYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTRLSDLGLPQCHRYWPEDG
.|  | .||||...   |  || |.    |   .||| | .|      .  || ||||   | .|||.|.|..    || | .. .    .|  |.| . 
nqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspf.lkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprna

HETYHIYEVHLVSEHIWCDDYLVRSfYLKNLQTSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVnkcfRGRSCPIVVHCSGGVGRTGCYILIDLVLNK
|   .. .. .  |    .  || .  |.     ||| .|.. .  ||| .|| . . .|.  ||.    | || | |.||| ||||.|  . ... |. 
hcclqfdklsvsyedstvnkslvtt.rlnlsyegetrlithwlwkewpdwqvpessevmlkilrki....rarstppvihcsagvgrsgtlmaveialqs

MMRGAKEIDIAATVEHLRD-QRPHMVKTKAQF
.       ||   | |||   |   |.|  |.
ihshftlpdikqivshlrvtgraasvqtlqqy
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 206-437 1.5e-33 110.8 In-house 52-281 (305) alignment 
Range on Protein: 206-437
Range on HMM: 52-281/305.0
QDKNVRKNRYSDVLPYDHNRVSLRETAnatGSDYINASFITDHDPRNPAYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTRLSDLGLPQCHRYWPEDGHE
 | .. ||||.||   |.. | | . .    |||| | ..      .  .|..|||| .|. .|| || .. |  || | .  .||  .| .|||    |
adiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqge

TYHIYEvHLVSEHIWCDDYLVRSFY----LKNLQT--SETRTVTQFHFLSWPDLNVPTTPKPLLEFRrkvnKCFRGRSCPIVVHCSGGVGRTGCYILIDL
  ..    .| | .     . |       | ||    ... .| ....  |||  ||      ||.      . ||   ||||||| |.||||  . |. 
klelks.givvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslell....sairgskvpivvhcsagigrtgtivaiey

VLNKMMRGAKEIDIAATVEHLRDQRPHMVKTKAQFEFA
.|.|.    .   .   |  ||||| . ...  |. | 
ilekiaenkpcppmpelvkalrdqrafsiqndvqylfi
PTPc_DSPc_SM00012 341-443 8.8e-33 108.0 In-house 1-105 (105) alignment 
Range on Protein: 341-443
Range on HMM: 1-105/105.0
TVTQFHFLSWPDLNVPTTPKPLLEFRRKVNKCFRGRS--CPIVVHCSGGVGRTGCYILIDLVLNKMMRGAKEIDIAATVEHLRDQRPHMVKTKAQFEFAL
||...|...||| .||......||. |.|.|. . ..   |.||||| ||||||.....|..|...... ||.||  .|..||.|||.||.|..|. | .
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

TAVAE
.|..|
ralle
subfamily_CG42327_pd Subfamily CG42327 211-369 1.1e-31 104.7 In-house 30-190 (319) alignment 
Range on Protein: 211-369
Range on HMM: 30-190/319.0
RKNRYSDVLPYDHNRVSLRETANATGSDYINASFITDHDPRNPAYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTRLSDLGLPQCHRYWPE----DGHET
 |.|. .|.|  . || |.. ..   . |..||..  .|  .  |||.| .|  . ||||..||||   ||| || ||.||. .| .|.|     |....
dksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntsl

YHIYEVHLVSEHIwCDDYLVRSFYLKNLQTSETRTVTQFHFlSWPDLNVPTTPKPLLEFRRKV
|  . | |    .  | |.. .. ||... .|.| .| . .  |.. .||. ...|.    .|
yGdilvtlkgrev.kdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllev
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 206-441 7.5e-31 102.1 In-house 32-266 (285) alignment 
Range on Protein: 206-441
Range on HMM: 32-266/285.0
QDKNVRKNRYSDVLPYDHNRVSLRETanatGSDYINASFITDHDPRNPAYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTRLSDLGLPQCHRYWPEDGHE
 . |   |||.||   .  || |..       ||| ||..      . .||.|||||  |.||||.|.... .  .. |  | . |. .|  |.||   |
yeanpdlnryadvrcieetrvvlknh....drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge

T--YHIYEVHLVSE-HIWCDDYLVRSFYLKNL--QTSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNKCfRGRSCPIVVHCSGGVGRTGCYILIDLV
   .  ||. |           .. .. . |    .||   . . .   |||   |   .|..|. . |.|    .  ||.|||| |||||  .. ||  
vvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkv.npkekpicvhcsagvgrtatfvgidya

LNKMMRGaKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAV
  ..|    .|..   |  .|  | . |... || |    .
tirimen.pniemldivremramrfqavqshmqflflyvvl
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 207-445 8.7e-31 102.0 In-house 41-271 (288) alignment 
Range on Protein: 207-445
Range on HMM: 41-271/288.0
DKNVRKNRYSDVLPYDHNRVSLRetanATGSDYINASFITDHdPRNPAYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTRLSDLGLPQCHRYWPEDGHET
 .|  ..|| ..   |  || |          ||.|  .. . . .   | .| ||  |.  .|.|. |..|  || |..| ..|...   |.|    |.
ianptrdryenlprcditrvkls....ddpdfyiaanvvssa.kykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGek

YHIYEVHLVSEHIWC-DDYLVRSFYLKNLQTSETRT-VTQFHFLSWPDLNVPTTPKPLLEFRRKVnkcfRGRSCPIVVHCSGGVGRTGCYILIdLVLNKM
 .|  .  |  .     | ||.   |.. .. |..  | . |.| |.|  ||   .. | .   .    .    |||||.| ||||||  ||| |.  ..
arigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgtlili.liales

MRGAKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAEEV
.|    . |   ...||..| . ..|. |. ..   | ||.
lrlddflgirsllaklreerfkaiqtemqylyvhrcvleel
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 207-435 2.1e-30 100.3 In-house 50-280 (310) alignment 
Range on Protein: 207-435
Range on HMM: 50-280/310.0
DKNVRKNRYSDVLPYDHNRVSLRETaNATGSDYINASFITDHDPRNpAYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTRLSDLGLPQCHRYWPEDG-HE
 |.. |||||||.  |  || |.   ..   ||| | ..     |. ..| .|||| ||. |||.|....    |. | . .. | |.|  |||  |  |
kkymhknrysdvvcldtsrvklkid.ksryedyihanyvktnylrs.tficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvte

TYHIYEVHLVSEHI--WCDDYLVRSFYLKNLQTSETR------TVTQFHFLSWPDLNVPTTpKPLLEFRRKVNKCfrgRSCPIVVHCSGGVGRTGCYILI
||    |  .||    .    |  .|   |.   |         |.  ..  |||  ||   |     .| . .    |  | ||||| |..|... . .
tygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpde.kchtvpqrllaqv...rhgpcvvhcsagkdrlyvvval

DLVLNKMMRGAKeIDIAATVEHLRDQRPHMVKTKAQFE
.| ..|. || | .|.   . .|. .|   ..|. |. 
klkidkldrglk.vdaeevktellksraiciqtelqyl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 208-310 1.6e-27 91.2 In-house 46-161 (350) alignment 
Range on Protein: 208-310
Range on HMM: 46-161/350.0
KNVRKNRYSDVLPYDHNRVSLRE--------TANATGSDYINASFITDH---DPRNPAY--IATQGPLAHTVSDFWQMVWEQGVVVIVNLTRLSDLGLPQ
.   ||||...|||.|.|| |..             ..|||||...         || .  ||||.||  || ||.... . .| ||. || . .|.| .
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek

CHRYWPEDGHETYHIY
|.|||.| . . ... 
cyrYWqegsydditvk
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 240-434 3.7e-27 89.8 In-house 78-270 (301) alignment 
Range on Protein: 240-434
Range on HMM: 78-270/301.0
INASFITDHdPRNPAYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTRLSDLGLPQCHRYWPEDGHETYHI--YEVHLVS-EHIWCDDYLVRSFYLKNL-Q
| | .|  .  .   .|||||||  |  ||| |.    |  || |..  .    .|. | | . .|. .|  ....... |.|  ..   |.. ...  .
ihanwipts.GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstg

TSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNKCfrgrSCPIVVHCSGGVGRTGCYILIDLvLNKMMRGAKEIDIAATVEHLRDQRPHMVKTKAQF
  .||||| . . .|.| .|| .   | ..   | |       ||||||| |.||. ..|  .  | . .   ..|... ...|||..| . |.|. |.
kfatrtvthyqysewtdrgvPkshaelfdlmelvkks....ekPivvhcsaGiGrsvafigtey.lareveadptieltealkhlrehrwngvqtnsql
0048076 (Phosphotyrosine protein) phosphatases II 312-439 5.5e-25 83.1 In-house 36-137 (145) alignment 
Range on Protein: 312-439
Range on HMM: 36-137/145.0
VhlvsehiwcddylvrsfylKNLQTSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNKCFRGRsCPIVVHCSGGVGRTGCYILIDLVLNkmmrgaKEI
.                    . .. ..|...|...|.||| .||. .. |||| . .... .   .|..|||| ||||||......|.|       . .
l...................tselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll......lgv

DIAATVEHLRDQRPHMVKTKAQFEFALT
..  ..|..| |||..| .  |..| . 
sleealelvrsqrpgavpnpgqlrflye
0048179 (Phosphotyrosine protein) phosphatases II 324-437 3e-24 80.8 In-house 31-137 (144) alignment 
Range on Protein: 324-437
Range on HMM: 31-137/144.0
YLVRSFYLKNLQTSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNKCFRgRSCPIVVHCSGGVGRTGCYILIDLVLnkmmrgAKEIDIAATVEHLRDQ
..| ..  .  .....|...|...|.||| .||. .. |||| . .... . ...|..||||.||||||......|..       . ...  .....| .
ttvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylmk......klglsleealalvrsr

RPHMVKTKAQFEFA
||..| .  |..| 
rpgavpnpgqlrfL
subfamily_egg_pd Subfamily egg 204-442 1.4e-23 78.1 In-house 35-267 (307) alignment 
Range on Protein: 204-442
Range on HMM: 35-267/307.0
GKQDKNVRKNRYSDVLPYDHNRVSLRETANATGSDYINASFITDhDPRNPAYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTRLSDLglPQCHRYWPEDG
  .| |  | |   |   |  || |.        |.| |  .   .|    .| .| ||  || |||.||... |  || ||   .    .|. |||   
aasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkG.kpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkae

HETYHIYEVHLVSEHIWCD---DYLVRSFYLKNLQTSetRTVTQFHFLSWpDLN-VPTTPKPLlefrrKVNKCFRGRSCPIVVHCSGGVGRTGCYILIDL
 ..  .    |  | .  |   | | |   || . .   .         . |.| .     ||     .| .  |  | |.||..  || .... . |..
sdslvtvpGslrienlkvdskadplfrvtklklvGgd..deerflehwqg.dvnnssdvyspl.....rvlrklrnlskpvvvqdilGvskaatlvaiei

VLNKMMRGA-KEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVA
 | ...||      .  .|  || .|.  |..  .. |    |.
allsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 187-445 8e-23 75.5 In-house 27-279 (303) alignment 
Range on Protein: 187-445
Range on HMM: 27-279/303.0
EWEALCNYeAEPSVADlGKQDKNVRKNRYSDVLPYDHNRVSLretanaTGSDYINASFItDHDPRNPAyIATQGPLAHTVSDFWQMVWEQGVVVIVNLTR
|.| ...|   |||.   .  ||. |||. ||.  || .| |      . | || ||.. . | .. | | || ||.|| .|||||. || | ... |  
efekvvsy.lppsvsk.nqfvknmdknrfvdvicldhskvkl......sdssyihasyl.eldsskka.iltqlplshtaadfwqmiieqkvkcvllllt

LSDLGLPQCHRYWPEDghETYHIYEVHLVSEHIWCDDYLVRSFYLKNLQTSETRTV---TQFHFLSWPDLNVPTTPKP-LLEFRRKVNKCFRG--RSCPI
 |.      .  .|..  . .  .|   .    .    |.  . || |  |.          |. .||  ..|.   | ..    ...  .|    | | 
dseydklggdsvfprn..qdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstpt

VVHCSGGVGRTGCYILIDLVLNKMMRGAKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAEEV
|     |.||.| . |..     .      .|.   .| .|. | | |.  .|| .  | .|| |
vymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehv
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 257-442 1.9e-22 74.6 In-house 39-218 (255) alignment 
Range on Protein: 257-442
Range on HMM: 39-218/255.0
AtqgplahTVSDFWQMVWEQGVVVIVNLTRLSDLGLPQCHRYWPEDGHETYHIYEVHLVSEHiWCDDYLVRSFYL-KNLQ-TSETRTVTQFHFLSWPDLN
        ||  |.|..  ..  |.| |. . . |  .|..|.| .  |   . .| ... .    | ..|   .  .|    .|.||. ...  |.. |
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk.ssadvvlrtleitstlgekkkthtvkhysykGWiekn

VPTTPKPLLEFRRKVNKcfrgrSCPIVVHCSGGVGRTGCYILIDLVLNKMMRGA-----KEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVA
 |  .. .|.  . | .     | ..||||| |.||.  ..|..||  ||.|        |.|    .|.|| .|.  ..|  |. |..  | 
aPelareilnilkvvrd.....sksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvl
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 222-441 2.3e-21 71.2 In-house 31-255 (290) alignment 
Range on Protein: 222-441
Range on HMM: 31-255/290.0
DHNRVSLRETANATGSDYINASFITDhdPRNPAYIATQGPLAHT-------VSDFWQMVWEQGVVVIVNLTRLS----DLGLPQCHRYWPEDGHETYHIY
 ..|| |..  .   .||| |...|   | . . |.|| |....       . .|| |. .  |  .| |   .    ...| .| .| ||   |   . 
eatrvvLkgygkrfnddyiHAnrvtc..pnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfk

EVHLV-SEHIWCDDYLVRSFYLKnLQTSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNkCfrgRSCPIVVHCSGGVGRTGCYILIDLVLNKMMRGAK
 . .   . .  ||  .|   .|  .  |  |||   . .| .|||. ..| ||.  .||. .   .  |..|||  |. |  .   |.|   |..   .
gltvkCkskekeddvetRelvvk.fddeeeftvtHsllkgWnklnvqedtktllsliqkvk.a...sktpvivHcvdGiSrsAalaaiilgyQkiaetsg

EIDIAATVEHLRDQRPHMVKTKAQFEFALTAV
.. ... .. || || ... .. .. |.. ..
svkledvlkalrkqralaitsalelafvdagi
subfamily_hpo-7_pd Subfamily hpo-7 253-442 9.5e-21 68.9 In-house 38-224 (263) alignment 
Range on Protein: 253-442
Range on HMM: 38-224/263.0
PAYIAtqgpLAHTVSDFWQMVWEQGVVVIVNLTRLSDLGLPQCHRYWPEDGHETYHIYEVHLVSEHIWCdDYLVRSFYLKN-LQ-TSETRTVTQFHFLSW
  |.     |  |.  |.|..  ..  |.| |.   . |  .| .|.| .  |   . .| ... ..   | |...  | . |.   .|.||... .  |
nlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs.dvllktlellstlgeKkkthtvkhysykgW

PDLNVPTTPKPLLEfrrkVNKCFRGRsCPIVVHCSGGVGRTGCYILIDLVLNKMMRGA-----KEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVA
.. | |. ..  |.    . |  |.   ..||||| |.||.  . ...||  ||.|        |.|    .|.|| .|.  ..|  |. |..  | 
iekndpelareiln....ilkvarns.kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvL
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 323-444 5.2e-20 66.2 In-house 76-193 (440) alignment 
Range on Protein: 323-444
Range on HMM: 76-193/440.0
DYLVRSFylknLQTSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNKCF-RGRSCPIVVHCSGGVGRTGCYILIDLVLNKMMRgAKEIDIAATVEHLR
||.  |.    ..  |.||. |.|. .|||  ||    |.|.. . ||..  .  . |..|||| |.||||  | .| .| .  | . .||| . .. .|
dyinasy....ingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakr.sdqidifsfinsmr

DQRPHMVKTKAQFEFALTAVAEE
..||.||.|  |. |   || | 
nnrpqmvqtpeqyafvheavleg
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 179-444 1.1e-19 65.2 In-house 16-275 (312) alignment 
Range on Protein: 179-444
Range on HMM: 16-275/312.0
SNKNRLNKEWEALCNYEAEPSVADLGKQdKNvrKNRYSDVLPYDHNRVSLRETANAtgsdYINASFITDHDpRNPAYIATQGPLAHTVSDFWQMVWEQGV
|  ..| ||. |. |  ..  .. . |  |.   ||| ..  .|  | .|    |     || | |.     .   ...|||||  |.. |||..   | 
stpqqltkeykavgnivsdsectaflkf.kd..lnrypniqcwdrgrftlagdenf....yihanfvkict.kperfvctqgplentcthfwqlalslgs

VVIVNLTRLSDLGLPQCHRYWPE-------DGHETYHIYEVHLVSEHIWCDDYLVRSFYLKNLQTSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNK
. |. |. . . |  .| .|  .       . |  |  |   .       |    | . .    | .   . .. . ||||  .| .    | .   |.|
tsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkk

cfrgRSCPIVVHCSGGVGRTGCYILIDLVLNKmMRGAKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAEE
       |.. ||| ||||||  .||. ..   .|  .  ..  .   || .|   |.. .|. .|| .| | 
....dkkpviahcsagvgrtgtlaliesmiaa.lrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlef
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 254-436 2.2e-18 61.2 In-house 6-195 (199) alignment 
Range on Protein: 254-436
Range on HMM: 6-195/199.0
AYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTRLSDLGLPQCHRYWPEDGHETYHIYEVHLVSEHIW-CDDYLVRSFYLKNLQTS--ETRTVTQFHFLSW
 ||||| || .|..|||||||| |   || .         .   |||     | .   . .... |    || . .. | |  |.   || .... | ||
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PDLNVPTTPK--PLLEFRRKVNKCF-RGRSCPIVVHCSGGVGRTGCYILIDLVLNKMM-RGAKEIDIAATVEHLRDQRPHMVKTKAQFEF
 .   |       ..   |.| | . . . .|..|||| | | || .. .|. .       .  .|.      ||. |  .. .  ...|
kekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynf
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 254-436 2.2e-18 61.1 In-house 5-194 (198) alignment 
Range on Protein: 254-436
Range on HMM: 5-194/198.0
AYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTRLSDLGLPQCHRYWPEDGHETYHIYEVHLVSEHIW-CDDYLVRSFYLKNLQTS--ETRTVTQFHFLSW
 ||||| || .|..|||||||| |   || .         .   |||     | .   . .... |    || . .. | |  |.   || .... | ||
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PDLNVPTTPK--PLLEFRRKVNKCF-RGRSCPIVVHCSGGVGRTGCYILIDLVLNKMM-RGAKEIDIAATVEHLRDQRPHMVKTKAQFEF
 .   |       ..   |.| | . . . .|..|||| | | || .. .|. .       .  .|.      ||. |  .. .  ...|
kekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynf
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 337-437 3.1e-18 60.6 In-house 183-279 (305) alignment 
Range on Protein: 337-437
Range on HMM: 183-279/305.0
SETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVnkcfRGRSCPIVVHCSGGVGRTGCYILIDLVLNKMMRGAKEIDIAATVEHLRDQRPHMVKTKAQFEF
...| ||..|.  |||  ||..   .||.  |     |    ||||||| |.||||  .... .|.... | .  |    . ..|.||   ..| ||. |
ekarkvthyhwidwpdrgvpaadlailelleka....rpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylf

A
 
v
subfamily_eak_pd Subfamily eak 202-358 3.4e-18 60.1 In-house 45-197 (332) alignment 
Range on Protein: 202-358
Range on HMM: 45-197/332.0
DLGKQDKNVRKNrYSDVLPYDHNRVSLRETANAtGSDYINASFITDHDpRNPAYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTRLSDLGLPQCHRYWPE
  ... ..|..|   ...|||.. | |  .       ||||| .   .     || |  .    |  ||||| ||    || |    .|.| .  .|.|.
setarleavnrn.vvkivpydrylvrltssqln.rlGyinaslaefse.vGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpd

DGHE--TYHIYEVHLvSEHIWCDDYLVRSFYLKnlQTSETRTVTQFHFLSWPDLNVPTT
...|   . |..|.   |..  . . .| . |.  .  ||  |  ...  | ....|  
ktreelkfGildver.kefvkrniletrllels..kGnethrvlhykvfGwtettlpky
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 210-309 7.9e-18 58.9 In-house 49-163 (349) alignment 
Range on Protein: 210-309
Range on HMM: 49-163/349.0
VRKNRYSDVLPYDHNRVSLRETAN--------------ATGSDYINASFITDHD-PRNPAYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTRLSDLGLPQ
  ||||.|.|||.| || |... .              .   ||||| ..       .  ||||| ||  || ||....  .|| ... |.   .|.| .
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslek

CHRYWPEDGHETYHI
|..|| |  .. ...
cdiywqelsysnitv
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 193-302 4.1e-17 56.6 In-house 80-181 (244) alignment 
Range on Protein: 193-302
Range on HMM: 80-181/244.0
NYEAEPSVADLGKQDKNVRKNRYSDVLPYDHNRVSLRETanATGSDYINASFITDHdPRNPAYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTRLSDlgl
    .|||     . .|  ||| .  ||.| ||| | .   . |  ||||||.     |   || || ||| |  |||.|. |. | |.| |  . .   
iirpdpsvmkdafnpnnswknregaglpfdfnrvplskg..smgntyinasfvgcl.grtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsvee...

pqCHRYWPED
     |||. 
..edeywpds
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 205-307 2.5e-16 54.3 In-house 44-142 (305) alignment 
Range on Protein: 205-307
Range on HMM: 44-142/305.0
KQDKNVRKNRYSDVLPYDHNRVSLretANATGSDYINASFITDhdPRNP-AYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTRLSDLGLPQCHRYWPEDG
|. ..  |||| ||   |.||| |    ..   .|| | ...   | ||  .| || || .| .||| | ... |  |  |  | . |  .|. |.. . 
keaqeagknrykdvgcldnnrvkl...egpwpheyihanyvst..ptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskd

HETY
... 
kdvl
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 207-437 2.7e-16 53.9 In-house 49-277 (302) alignment 
Range on Protein: 207-437
Range on HMM: 49-277/302.0
DKNVRKNRYSDVLPYDHNRVSLRETANatgsDYINASFITDHDPRnPAYIATQGPLAHTV---SDFWQMVWEQGVVVIVNLTRLSDLGLpQCHRYWPEDg
 ||..||.  ||  .|.|.| | ....    .|.||| ..  . . .  | .| |   ..    .||.||... .| .| | .  .|     . ..|.  
kknlkknqsedvpildsnlvkleaepd....syvnaskvevPelt.rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkk.

HETYHIYEVHLVSEH-IWCDDYLVRSFYLKNL--QTSETRTVTQFHFLSWPDLNVPTTPKPLLEFRRKV-NKCFRGRScPIVVHCSGGVGRTGCYILIDL
 ..|. |.   |    .   .  .  ...  |    |..  ..  ..  |.. .||.    | .   || .|   . . ..|.    |.|| |  .   .
sgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikade.ntvivSknGaGRagafltlav

VLNKMMRGaKEIDIAATVEHLRDQRPHMVKTKAQFEFA
...|. .| ||  |. .|. .| |||..| .  |. . 
aveklqkg.kepnikeivksiRsqRpravdslkQyvsl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 375-445 3.6e-15 50.6 In-house 226-295 (297) alignment 
Range on Protein: 375-445
Range on HMM: 226-295/297.0
GRSCPIVVHCSGGVGRTGCYILIDLVLNKMMRGaKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAEEV
 |. ...|||| ||||.|  .| | .|.|. .. .  |.|| ...||.||. .|.|  |||.  .|| . .
prnayllvhcsaGvGrsGvvvlsdvilaklrkk.ripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_CG42327_pd Subfamily CG42327 374-440 9.3e-14 45.8 In-house 244-310 (319) alignment 
Range on Protein: 374-440
Range on HMM: 244-310/319.0
RGRSCPIVVHCSGGVGRTGCYILIDLVLNKMMRGAKEIDIAATVEHLRDQRPHMVKTKAQFEFALTA
| .  |.||||| ||||||  |  |. ....    . .||  .| ..| .| . |.|| |.||    
resqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 261-443 9.2e-13 42.3 In-house 99-286 (302) alignment 
Range on Protein: 261-443
Range on HMM: 99-286/302.0
PLAHTVSDFWQMVWEQGVVVIVNLTRLSDLGLPQCHRYWPEDGH--ETYHIYEVHLVSEHIWCDDYL------VRSFYLKNLQT--SETRTVTQFHFLSW
|   |.  .| .. .  | ..|.|. . . .  .|  |. ..     ..  | |. || .   ...       . .  .|| ..     .||  ..| .|
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PDLNVPTTPKPLLEFRRKvNKCFRgrsCPIVVHCSGGVGRTGCYILIDLVLNKMMrGAKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAE
||   |  ... |.  .   ....     ..|||| ||||||  . |   ..  .   |  |..  |  .|. |   |... |  . |  |. 
pdhGapkeaytaldilkf.cesyk...knvlvhcsaGvGrtGtlvaikyGiqlcs.kkkvtdllsivlpvrqcryGavqdeqqliylllcvtk
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 337-440 5.2e-12 40.1 In-house 212-339 (350) alignment 
Range on Protein: 337-440
Range on HMM: 212-339/350.0
SETRTVTQFHFLSWPDLNVPTTPKPLLEFRR----------KVNKCFRGRSCPIVVHCSGGVGRTGCYILIDLVLN-------------KMMRGAKEID-
|.   | |...  |.||..   |. .|.               .     || ||.|||| |||||| .. .| .|.             |. . ||  | 
sdPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDl

IAATVEHLRDQRPHMVKTKAQFEFALTA
|  .| .|| ||  ||... || |   |
isiivnelrkqrismvqnldqfifiYea
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 191-283 4.9e-11 36.7 In-house 21-115 (347) alignment 
Range on Protein: 191-283
Range on HMM: 21-115/347.0
LCNYeaEPSVADLGKQDKNVRKNRYSDVLPYDHNRVSLRE-TANAT----GSDYINASFITdHDPRNPAYIATQGPLAHTVSDFWQMVWEQGVVVIVN
|.||   ||     . .|.. |||  ||   |  || |    .. .       ||||| |   |  .  || || || .|| |||.||    |  .| 
lany..spskftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashik.fdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt
0038934 (Phosphotyrosine protein) phosphatases II 340-439 5.5e-11 37.9 In-house 77-171 (194) alignment 
Range on Protein: 340-439
Range on HMM: 77-171/194.0
RTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNKCFRG-RSCPIVVHCSGGVGRTGCYILIDLVLNKMMrgakeiDIAATVEHLRDQRPHMVKTKAQFEFAL
.   ... | .|| ... . . ||.| . |.. ..   .. ..||| .|.||||. .   |.    |      .  . ....|. ||... .  ..|  |
kagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgm......saeeAialfrekRpgaipnqdyleall

T
.
k
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 219-317 9.5e-11 36.1 In-house 3-85 (130) alignment 
Range on Protein: 219-317
Range on HMM: 3-85/130.0
LPYDHNRVSlretanatGSDYINASFITDHDpRNPAYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTRLSDlglpqCHRYWPEDghETYHIYEVHLVSE
|... .|.         | .||||||.   . |   |. || ||| |  |||.|. |. | |.| |  . .        |||.   | .. || ...  
lefevsrlq........gntyinasfvGllg.rtaeylltqhpladtsmdfwkmmleryvnvlvvlgsvee.....edeywpds..ePlewyeediivt
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 380-444 3.5e-10 34.1 In-house 1-64 (69) alignment 
Range on Protein: 380-444
Range on HMM: 1-64/69.0
IVVHCSGGVGRTGCYILIDLVLNKmMRGAKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAEE
.||||| | |||| .| | . . . ..  | .||   | ..|  || ||  . .. |   |..| 
mvvhcssgtgrtgtfiaimvemar.ikseklvdifnnvqymrkcrpmmvmneieyifihdalvea
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 177-260 4.4e-10 33.6 In-house 18-95 (95) alignment 
Range on Protein: 177-260
Range on HMM: 18-95/95.0
HLSNKNRLNKEWEALCNYEAEPSvaDLGKQDKNVRKNRYSDVLPYDHNRVSLREtanATGSDYINASFITDHdPRNPAYIATQG
|    . ...|. ..      |     |  . |. |||. ...|||  || |        |||||| |.  .  |. .|||.||
hsnsdqefdnefksismtsgapy..tvgsseanipknrflnifpydatrvvltt...krdsdyinacfvdgy.arkncyiaaqg
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 381-444 5.4e-10 33.5 In-house 1-63 (69) alignment 
Range on Protein: 381-444
Range on HMM: 1-63/69.0
VVHCSGGVGRTGCYILIDLVLNKmMRGAKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAEE
||||| | |||| .| | . . . ..  | .||   |...|  || ||  . .. |   |..| 
vvhcssGtGrtGtfiaimvemar.ikseklvdifnnvqymrkcrpmmvmneneymfihdalvea
subfamily_PTPDC1_pd Subfamily PTPDC1 316-436 1.1e-09 33.0 In-house 57-167 (182) alignment 
Range on Protein: 316-436
Range on HMM: 57-167/182.0
SEHIWCDDYLVRSFYLKNLQTSETRTVTqFHFLSWPDLNVPTTpKPLLEFRRKVNKCFRGRscPIVVHCSGGVGRTGCYILIDLVLNKMMRGAKeidiaa
 ||  |   | .| .  .|.    . .. .. ..|.| .|..  . .|.  . |. . .     . |||  | ||||  |   || .| . ..|      
gehasCGagleesGfsYdlealmeqgiy.vynfgwkDygvasl.eriLdivkvvafalqeg..kvavhChaGlGrtGvliacylvyakrltaek......

TVEHLRDQRPHMVKTKAQFEF
... .|..||. ..|. | |.
aiklvrskrpksiqtreqvel
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 175-249 1.6e-09 31.6 In-house 12-87 (440) alignment 
Range on Protein: 175-249
Range on HMM: 12-87/440.0
EDHLSNKNR---LNKEWEALCNYEAEPSvaDLGKQDKNVRKNRYSDVLPYDHNRVSLRETANATGSDYINASFITDHD
 |.. |. |    . ||  | .  ..||  |     .|  |||| ..| |||.|| | |      |||||||.|.  .
adyvqnnrrsrafedewsllpsglsqps..diaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingie
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 208-330 5.2e-09 29.3 In-house 26-112 (169) alignment 
Range on Protein: 208-330
Range on HMM: 26-112/169.0
KNVRKNRYSDVLPYDHNRVSLRETANATGSDYINAsfitdhdprnpayiatqgplahtvsdfwQMVWEQGVVVIVNLTRLSDlglpqCHRYWPEdgHETY
 |  ||| .  |   | || |.   .  |||||||                            .|.||    ||| |    |        .|||  .| |
cnetknrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlgdtdd.....knnfwpe..kedy

HIYEVHLVSEHiWCDDYLVRSFY
 ..   .. |  . |   ||.  
qlhpavilgew.ytdslyvrtdk
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 208-330 6.5e-09 28.8 In-house 25-111 (169) alignment 
Range on Protein: 208-330
Range on HMM: 25-111/169.0
KNVRKNRYSDVLPYDHNRVSLRETANATGSDYINAsfitdhdprnpayiatqgplahtvsdfwQMVWEQGVVVIVNLTRLSDlglpqCHRYWPEdgHETY
 |  ||| .  |   | || |.   .  |||||||                            .|.||    ||| |    |        .|||  .| |
cnetknrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlGdtdd.....knnfwpe..kedy

HIYEVHLVSEHiWCDDYLVRSFY
 ..   .. |  . |   ||.  
qlhpavilGew.ytdslyvrtdk
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 375-440 3.7e-08 27.1 In-house 263-339 (349) alignment 
Range on Protein: 375-440
Range on HMM: 263-339/349.0
GRSCPIVVHCSGGVGRTGCYILIDLVLN----------KMMRGAKEID-IAATVEHLRDQRPHMVKTKAQFEFALTA
 .. ...|||| | |||| .. .||.|.          |.   |.  | |  .| .|| ||  ||.  ||| . . |
dqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyea
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 253-302 2.2e-07 24.5 In-house 236-282 (440) alignment 
Range on Protein: 253-302
Range on HMM: 236-282/440.0
PAYIATQGPLAHTVSDFWQMVWEQGVVVIVNLTRLSDLglpQCHRYWPED
 |.|||| ||  || |||..| .  .  |. | .| |     |  ||| .
nafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvn
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 207-282 1.2e-06 22.3 In-house 32-105 (332) alignment 
Range on Protein: 207-282
Range on HMM: 32-105/332.0
DKNVRKNRYSDVLPYDHNRVSLREtaNATGSDYINASFItDHDPRNPAYIATQGPLA-HTVSDFWQMVWEQGVVVIV
 .|.  ||   .  .||.|| |    .    |. |||.. |   .. ||| .| |.  ||   ||.|| |.   .|.
lnnmdmnriphlycfdhsrvelap..qdgkddfynaswv.dgyskksayifaqapfndhteyvfwrmvserkpsmil
subfamily_DSP23_pd Subfamily DSP23 343-433 2.2e-06 22.4 In-house 52-134 (148) alignment 
Range on Protein: 343-433
Range on HMM: 52-134/148.0
TQFHFLSWPDLNvPTTPKPLLEFRRKVNKCfRGRSCPIVVHCSGGVGRTGCYILIDLVLNKMMRGAKeidiaaTVEHLRDQRPHMVKTKAQ
  .. |  .|   | ... . || | |..    ..  . |||  | ||||  .   || .. .  |.      ..  .| .||  |.|  |
ltlvrlriddyh.ppaleqvvefvrvveea.eekneavsvhcllgrgrtgtmlacylvkerklaaae......aiaevrrlrpgsvetveq
PTEN_1 333-427 4.4e-06 21.6 In-house 86-174 (196) alignment 
Range on Protein: 333-427
Range on HMM: 86-174/196.0
NLQTSETRTVTQFHFlSWPDLNVPTTpKPLLEFRRKVNKCFRGRSC--PIVVHCSGGVGRTGCYILIDLVLNKMmrgakeIDIAATVEHLRDQRPHM
.|.. . . |.. || ...| ..|.    |... ...  . . ...   ..||| .|.||.|. .   |.  .        .   ..|..|..||..
dleeffksgveylhf.pieDhgapsl.selfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk......ltadeAlelvrekRppg