Gene INPP5 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Sac
Subfamily INPP5F
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP083_AA protein Get Run
NvecP083_AA_239-565 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_INPP5F_pd Subfamily INPP5F 48-594 9.4e-207 680.2 In-house 3-527 (951) alignment 
Range on Protein: 48-594
Range on HMM: 3-527/951.0
VYGVIGKIQFFPGGDWKLLVITKRTLLGLFPG-----NHEVYRVDRVAYLPLSPGDVPELELDPCEKHQSG----GRGIKRDTEGQQKSFQQTWKSIKTA
||||||||...   ..||........|||.|      ..||....|||.|.|| .|..|||.. |......    |. |....||..|.....|..|...
vygvigkillvseeerkLvivsessilgllpvqkkeskkevvaiervakldlsekdskelekeectgliglielegkiivatiegkskvnnkkwdlidid

ATNIkenvksTSTTKEPKDRERDKLERRLVEELLKMFNDsDSFYYSPTGDITNTLQRQCGDHYDHSLPLWkrvDKRFFWNSHMLHDLINNEDPLASSWIL
....      .....| ...|..|||.||.||| |...| .|||||.. |.|||||... .. ..|.. |   |.|||||...|.||||..| |......
ssgy......lqlkeekeqneeeklekrlleelkkllsd.gsFYysldfDltntlqkrgleeksestddw...derFfWNkfllkdlinyrdkldkeflt

PVIQGYCSIVHCHNMfeeddmeeqsdiqigalpPEEFDLLLISRRSIFRAGTRYKRRGVDDDGEVANYVETEQIVRTEIHSVSFVQVRGSVPVFWSQPGY
|||||.... .....                  .....| |||||| .|||||.||||.||||.|||.||||.|...| ...||.|.||||||||.|.|.
pviqGfvetkeisie..................klkvsltlisrrSrkragtrfkrrGidddgnvAnfvEtElilsvekyvlsftqirGSvPvfweqsgk

KYRPPPRLDKDEMDTQAAFRHHFSHQLSLYGGVVVVNLVDQTGREKIISDVFMRHILAYNCPLLTYITFDFHEYCRGMKFENVSVLVDSIGDVIKDMRYC
||.|.......|..||.||..||..||. || ||.|||..|...||..|. .....|..... ...|.|||||...|.|||||| |...| . ||...|.
kykpkikitrseeetqpaFdehfkeqlkkygkvvivnllsqkssekklskaykeqllkleskdvflikfdfheetsgekfenvsklielikneikevgyf

WTDPKG-IICEQRSVFRVNCMDCLDRTNVVQAALARHLLEMQLRKLGKLMPDQTLP-ASIRAPFKEMWANNGDAISRQYAGTAALKGDFTRTGERKFTGL
..| |. .|.||..|||.||.||||||||||.|.....||.||.|||...|..... ....  .|..||.||||||||||||.|||||.||.||||..|.
sydvkekviseqkgvfRtnclDcldrtNvvqqaiskavlelqleklglfepessiddeellqklkklWadngdaisrqYagtnalkgdltrkgerklaGv

MKDGYNSANRYYLNRFKAAYRQTLIDMMLGNPPTEDLSALIDALRSDGQEEEqwtmeR
.||||.|..|||||.|| .|||. ||..||. |... . |||. .....||.     |
lkdgyksvsryylnnfkdkyrqkvidlllGklpkqevvelidpkkeekeeel.....r
subfamily_SAC1_pd Subfamily SAC1 152-567 6.9e-136 444.5 In-house 52-452 (458) alignment 
Range on Protein: 152-567
Range on HMM: 52-452/458.0
TKEPKDRERDKLERRLVEELLKMFNDSDSFYYSPTGDITNTLQRQ--CGDHYDHSLPLWKRVDKRFFWNSHMLHDLINneDPLASSWILPVIQGYCSIVH
... .. |..| | .   .||.   .|..||.| | |.||.|||.   . .  .. .|..|.|.|||||.|.|.|| .  .| ..|.|||||.|. .|..
knslslteeqkkeekeylkllelvlksetfYfsytydltnslqrlekvtsaalkerslleradeRffwnkhlledlrk..epelesfilPvikGfikike

ChnMfeeddmeeqsdiqigaLPPEEFDLLLISRRSIFRAGTRYKRRGVDDDGEVANYVETEQIVRTEIHSVSFVQVRGSVPVFWSQPGY-KYRPPPRLDk
.  .                |  .|... |||||||||||||| .|||| .|.|||.||||||| .|.. .||||||||.|..||| .  ||.| ..|  
l..s................lnakeikfilisRRsifRaGtRyfvRGvdkeGnvanfvEtEqiveaekaltsFvqvRGsiPllWsqkpnLkykPkvkls.

DEMDTQAAFRHHFSHQLSLYGGVVVVNLVDQTGREKIISDVFMRHILAYNCPLLTYITFDFHEYCRGMKFENVSVLVDSIGDVIKDMRYCWT-DPKGIIC
.. |...||..|...| .|||  |.||||||.|.|| . . . . . |.| . . |..||||. || |... ...|.|.. .  ... | .. . | |. 
esedsldafkkhldeqielygenvlvnLvdqkGsEkklgeayesvvralnkkkikyvafDFHkeCrkmrwdrlklLidqlekelsqegyflkseekkivk

EQRSVFRVNCMDCLDRTNVVQAALARHLLEMQLRKLGKLMPDQTLP--ASIRAPFKEMWANNGDAISRQYAGTAALKGDFTRTGERKFTGLMKDGYNSAN
||..|.| ||.||||||||||. |||. |. ||..|| |  ...|   |..   ||..||.|.||.| |||||.||| |||||| |...|...||.||. 
eqkgvvRtnCiDcLDRtnvvqsllarevLqkqleslgvlateskledsaeletsfknlwadnadavsvqYaGtgAlKtDftRtGkrtllGalrDgvnsvs

RYYLNRFKAAYRQTLIDMMLGN
||| | |.  .||  ||..||.
ryyknnfldgerqdsidLflgk
Sac_COG5329 48-587 7.5e-125 409.3 In-house 61-538 (1070) alignment 
Range on Protein: 48-587
Range on HMM: 61-538/1070.0
VYGVIGKIQFfpGGDWKLLVITKRTLLGLFPGNHEVYRVDRVAYLPLSPGDVPELELDPcekhqsggrgikrdtegqqksfqqtwksiktaatnikenvK
.|||.| |..   |.  | |||. .  .   .....|... |  ..|   . ...| ..                                         
iygvlGliel..egslflivitgkskvaqvipgetiykilavdfislnnnkwddeeies........................................d

---------StsttkepkdrerdklerRLVEELLKmFNDSDSFYYSPTGDITNTLQRQcGDHyDHSlPLWKRVDKRFFWNSHMLHDLINNEDP---LAS-
         .                   . || |     .|||.| . |||||||.. ...  .. . ... |..|.||| .| .|||. .    |.. 
easteklrse.................hpcselkk.LlsngsFYfStdfditntLqkr.lke.ele.lsvdtadeefmwnsflleelinyrsklsslekq

-----SWILPVIQGYCsivhchnmfeeddmeEQSDIQIGalpPEEFDLLLISRRSIFRAGTRYKRRGVDDDGEVANYVETEQIVRTEIHSVSFVQVRGSV
      .. .||.|..               |. .|...   ..   | ||||||. |||||. .||||||| |||.||||||| .. . .||.|||||.
lldnagFlttvIrGFa...............etvfikvk...kktiaLtlISRrSskragtRflarGvDddGnvanFVETEqIvyssqycfsFtQvRGSi

PVFWSQ-PGYKYRPPPRLDKDEMDTQAAFRHHFSHQLSLYGGVVVVNLVDQTGREKIISDVFMRHILAYNCPLLTYITFDFHEYCRGMKFENVSVLVDSI
|.||.|  .  . |. .  ..   ||.||  ||. . . ||.|..|||... ..|. .|  . .|. . . | .....||||  .. ..|..|. | . |
PiFWeqesnsligpkiqitrsseatqsafdkHFdklfekYGdvhivNLlktKssEieLseryekhlklsekpkihlteFdfhketsqdgfddvkkLlpli

GDVIKDMRYCW--TDPKGIICEQRSVFRVNCMDCLDRTNVVQAALARHLLEMQLRKLGKLMPDQTLpaSIRAPFKEMWANNGDAISRQYAGTAALKGDFT
 . .... |    .  . .| || .|||.||.||||||||.|  ... .| .|.|....    ..   ..   ..|.||.||||||..| || |||..||
eqdllefgyfsydvkegkliseQdGVfRtNClDCLDRTNviQqliskrvlleqfrsikvisaidde..dflqklneLWadnGDaisqiYTGtgalkssft

RTGERKFTGLMKDGYNSANRYYLNRFKAAYRQTLIDMMLGNPPTEDLSALIDALRSDGQEE
|.| | . | ..|  .|. |.|.|.|  . .|. ||..||  |... . |.|   .. ...
rkgkrsiagalsDatkSvsRmyinnfvDkekQdaidllLgklpdqeavelydpineyvnlr
Syja_N SacI homology domain 48-420 2.6e-94 307.0 Pfam-A 1-319 (319) alignment 
Range on Protein: 48-420
Range on HMM: 1-319/319.0
VYGVIGKIQFFPggDWKLLVITKRTLLGLFPGNHEVYRVDRVAYLPLSPGDVPELELDpcekhqsggrgikrdtegqqksfqqtwksiKtaatnikenvk
.||..| |...   .  |||||||.  . . |.|..|....|. .||.  .  . . .                              .           
aygilGlirlls..esyllvitkrekvakirgehpiykiksvefiplnseeeessaie..............................e...........

ststtkepkDRERDKLERRLVEELLKMFNDSDSFYYSPTGDITNTLQRQCGDHY------DHSLPLWKRVDKRFFWNSHMLHDLINNEdPLASSWILPVI
         ..|... | . . .||| .  |.|||.| . |.|..|||.. ..       ..||||.|.||.||.||...|..||. . . .|.|.||.|
.........ekeeeekeeekllkllkkllssgsfYfSydyDltrslqrksekeeeekeeeskslpllkevderFvWNrnllkplielk.ldlsrwllpli

QGYCSIVHCHNMfeeddmeeqsdiqigalPPEEFDLLLISRRSIFRAGTRYKRRGVDDDGEVANYVETEQIVR-T-E--IHSVSFVQVRGSVPVFWSQ-P
||.... ...                     ....|.||||||. ||||||.|||.||||.|||.|||||||. . |   . .||||.|||||.||.| .
qGfveqrsievk.................skkkveltLIsRrsvkraGtRylrRGidddGnvANfvEtEqivsekkeeskrvfSfvqiRGSvPlfWeqas

GYKYRPPPRLDKDEMDTQAAFRHHFSHQLSLYGGVVVVNLVDQTGREKIISDVFMRHILAY-----NCPLLTYITFDFHEYCRGMKFEN
.....|........ ..|.||..||..... || .|||||....|||| .|. . ..| ..     .   | ||.||||. |.|.||||
nlslkpkikitrsseasqkafkkHfkklikrYgkivvvnLlekkgrEkkLseayeelinklnkklkekkklkyiefDfhkeckgkkfen
Syja_N SacI homology domain 48-420 2.6e-94 307.0 In-house 1-319 (319) alignment 
Range on Protein: 48-420
Range on HMM: 1-319/319.0
VYGVIGKIQFFPggDWKLLVITKRTLLGLFPGNHEVYRVDRVAYLPLSPGDVPELELDpcekhqsggrgikrdtegqqksfqqtwksiKtaatnikenvk
.||..| |...   .  |||||||.  . . |.|..|....|. .||.  .  . . .                              .           
aygilGlirlls..esyllvitkrekvakirgehpiykiksvefiplnseeeessaie..............................e...........

ststtkepkDRERDKLERRLVEELLKMFNDSDSFYYSPTGDITNTLQRQCGDHY------DHSLPLWKRVDKRFFWNSHMLHDLINNEdPLASSWILPVI
         ..|... | . . .||| .  |.|||.| . |.|..|||.. ..       ..||||.|.||.||.||...|..||. . . .|.|.||.|
.........ekeeeekeeekllkllkkllssgsfYfSydyDltrslqrksekeeeekeeeskslpllkevderFvWNrnllkplielk.ldlsrwllpli

QGYCSIVHCHNMfeeddmeeqsdiqigalPPEEFDLLLISRRSIFRAGTRYKRRGVDDDGEVANYVETEQIVR-T-E--IHSVSFVQVRGSVPVFWSQ-P
||.... ...                     ....|.||||||. ||||||.|||.||||.|||.|||||||. . |   . .||||.|||||.||.| .
qGfveqrsievk.................skkkveltLIsRrsvkraGtRylrRGidddGnvANfvEtEqivsekkeeskrvfSfvqiRGSvPlfWeqas

GYKYRPPPRLDKDEMDTQAAFRHHFSHQLSLYGGVVVVNLVDQTGREKIISDVFMRHILAY-----NCPLLTYITFDFHEYCRGMKFEN
.....|........ ..|.||..||..... || .|||||....|||| .|. . ..| ..     .   | ||.||||. |.|.||||
nlslkpkikitrsseasqkafkkHfkklikrYgkivvvnLlekkgrEkkLseayeelinklnkklkekkklkyiefDfhkeckgkkfen
subfamily_Synaptojanin_pd Subfamily Synaptojanin 163-571 6.1e-77 250.7 In-house 59-439 (754) alignment 
Range on Protein: 163-571
Range on HMM: 59-439/754.0
LERRLVEeLLKMFNdSDSFYYSPTGDITNT--LQRQCGDHYDHSlplwkRVDKRFFWNShMLHDLINNEDPLASSWILPVIQGYCSIvhcHNMFeeddme
 | |..| | |... |..||.| . | ...  |....  .....       |.|||||  .||  ... .  ...|.|.|. |  .|   . ..      
dedriie.lkklla.sgtfyfsssadsasrldlslsaqrrkqee.....sednrffWnr.slhlhlqrfgvncddWllkvmcGsvei...rtvy......

eqsdiqIGAlppEEFDLLLISRRSIFRAGTRYKRRGVDDDGEVANYVETEQIVRTEIHSVSFVQVRGSVPVFWSQPGYKYR-PPPRLDKDEMDTQAAFRH
      .||   ..   .|||| |  |||||.. |||.|.|.|||.|||||..  . . .||||.|||||.||.||| .      .| ..   ..|||  
......aga...kqakaalisrlsceraGtrfnvrGvndeGnvanfveteqvillddkvtsfvqirGsvPlfWeqPGlqvGshkvklsrgfeasaaafdr

HFSHQLSLYGGVVVVNLVDQTGREKIISDVFMRHILAYNC-PLLTYITFDFHEYCRGMKFENVSVLVDSIGDV-IKDMRYCWTDPKGIICEQRSVFRVNC
|.... . || ||.|||. . . |...|. | .|  | .  . . ...||.|. ..| | |... |.. .    .... .  .  | .  ||  | ||||
hleqlkeryGevvivnllGskegeevlskafkkhlkasehakdvpfvkfdyhqkvkggkkeklekllkkqlklflesasfflskgkevekeqtGvlrvnC

MDCLDRTNVVQAALARHLLEMQLRKLGkLMPDQTLPASIRAPFKEMWANNGDAISRQYAGTAALKGDftrtgeRKfTGLMKDGYNSANRYYLNRFKAAYR
.||||||| ||..|. ..|| ||  |. |   . .   ..  ||..| .||| ||. |||| ||.|.       | .. .|||  | .|   | |  . .
lDCldrtnavqtvlglevlekqlealk.lsskesvvsrfeevfkslWsknGdeiskiyaGtgalegk......ak.vsklkdgarsvartiqnnfldssk

QTLIDMML-GNPPTE
|  ||..| ||  .|
qeaidllllgntyve
subfamily_FIG4_pd Subfamily FIG4 159-567 1.7e-58 189.3 In-house 121-540 (569) alignment 
Range on Protein: 159-567
Range on HMM: 121-540/569.0
ERDKLERRLVeELLKMFNDSDSFYYSPTGDITNTLQRQCG--DHYDHSLPL-----------WKRVDKRFFWNSHMLHDLINNEDPlaSSWILPVIQGYC
|.   | |.. .|.|  . .  ||.| . |.|.|||      |. ...                . ...| ||...|. | .. ..   .|.| .| |..
ekssdearyl.klfkdvdltknfyfsysydltrtlqtnlllsdsnrekekaedrvditieakkldanekfvWnnflleplkdtvkt..fdWlleiihGfv

SivhchnmfeeddmeeQSDIQIgalPPEEFDLLLISRRSIFRAGTRYKRRGVDDDGEVANYVETEQIVR-------TEIHSVSFVQVRGSVPVFWSQPGY
|               ||.|..     .. .. ||.|||   ||.|. .|||. .|.|||.|||||||.       .. .  ||||.|||||..|||   
s...............qskisv...lgksiyvtliarrsskfaGarflkrGvnnkGdvaneveteqivheasegsldsdryssfvqlrGsvPlyWsqdas

KYRPPPRLDKDEMDTQAA-FRHHFSHQLSLYGG-VVVVNLVD---QTGREKIISDVFMRHILAYNCPL-----LTYITFDFHEYCRGMKFENVSVLVDSI
|  . |..  |..|  |     ||.. .. ||. ....|||    .. ||.|..  | . |   |  |     |.||..|.. . .  . . ..|| .  
klvtkPpikidvvdPfasaaalhfddlfqryGspiiilnlvkkkekrkresilleefeaaieylneflPeekklkyiswdmaraskskeenvlevlekya

GDVIKDMRYCWTDPKGIIC-EQRSVFRVNCMDCLDRTNVVQAALARHLLEMQLRKLGKLM-PDQTLPASIRAPFKEMWANNGDAISRQYAGTAALKGDFT
 ...|   .    |.      |. . |.||.|||||||. | ....  | .|| .|| .  .. .. . .   ..|.. . || .. ||.|.   .   |
eksvkktGiflsapdlestkiqeGivrtnCvdcldrtnaaqfvigkvalgyqlkslGiidesklefdsdvvrlleelyedlGdtlalqygGsqlvntikt

RTGERKFTGLMKDGYNSANRYYLNRFKAAYRQTLIDMMLGN
 .  ....   .|  .. .||| | |. | .|. |...|| 
yrkiaqwssksrdiletlkryysnsfvdadkqdainlflGv
hSac2 Inositol phosphatase 626-694 3.9e-19 57.4 Pfam-A 45-112 (115) alignment 
Range on Protein: 626-694
Range on HMM: 45-112/115.0
SATQDQDVILLLTYHAYYVASYDDEAEQITQYERIAIEDVEKIEIAAWSLIFVRSlFSSPSKCSHVRTI
.........|||| .|.||..||.| |..||.|||..|...|||| ..|   ...  .| . ...... 
ktlteeervLLLTdkalyvckYDfetekvtqferidLesikkieiGtysestlse.dksenlglrinyr
hSac2 Inositol phosphatase 584-621 1.9e-06 16.5 Pfam-A 29-65 (115) alignment 
Range on Protein: 584-621
Range on HMM: 29-65/115.0
GQEEEQWTMEREDPEGeSATQDQDVILLLTYHAYYVAS
..  . |.. . |.   .........|||| .|.||..
eeliggWlLvsidhsn.ktlteeervLLLTdkalyvck