Gene SAC1 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Sac
Subfamily SAC1
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP084_AA protein Get Run
NvecP084_AA_190-497 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_SAC1_pd Subfamily SAC1 54-504 1.4e-210 690.7 In-house 2-457 (458) alignment 
Range on Protein: 54-504
Range on HMM: 2-457/458.0
ADSVDIFGIMGIIHLLAGPYLIVITKKKLVGYIQGSEVWKVLQTNVIPFPRATLHLTESQQYHNKLYLSMVQSVLQTESFYFSCTYDLTHTLQRLSR-TS
|..|.|.||.|||.||.|.||||||||. || |.|. ...| ....||. ...|.|||.|. ..| ||.....||..|.||||.|||||..||||.. ||
aevvkiagilGiikLlsgkylivitkkeevgringkviyrvadveiipvkknslslteeqkkeekeylkllelvlksetfYfsytydltnslqrlekvts

PEFLQMPLYERVDPRFVWNSHLLTPFAVQPELQRFILPVMHGFISITSCSIKQRSFDFILISRRSCFRAGVRYFMRGLDGEGNAANYVETEQIIQFNTGT
... ...|.||.| ||.||.|||. .. .|||..|||||..|||.|...|.......||||||||.||||.|||.||.| |||.||.||||||..... .
aalkerslleradeRffwnkhlledlrkepelesfilPvikGfikikelslnakeikfilisRRsifRaGtRyfvRGvdkeGnvanfvEtEqiveaekal

SSFVQIRGSIPLYWTQRPNLKYKPKPQVNSSADHSLGFQYHIDNEIAHYKELVLINLIDQKGPEKVLGDRFSTIIRNSPYKETSYEAFDFHKECSKMRWD
.||||.||||||.|.|.||||||||.....|.|.. .|. |.|..|..|.| ||.||.|||| || ||.......|....|...|.||||||||.|||||
tsFvqvRGsiPllWsqkpnLkykPkvklsesedsldafkkhldeqielygenvlvnLvdqkGsEkklgeayesvvralnkkkikyvafDFHkeCrkmrwd

RLNLLIDRLSPDQKKFGYFSMGKDKDIQSEQKGVFRTNCIDSLDRTNVVQSMLARNSLQLQLEEYGVLATGERIVDHNDFEYTFKNVWADNADACSVQYA
||.||||.|.......|||.. ..|.|..|||||.||||||.|||||||||.|||..|| |||..|||||.... |....|..|||.|||||||.|||||
rlklLidqlekelsqegyflkseekkivkeqkgvvRtnCiDcLDRtnvvqsllarevLqkqleslgvlateskledsaeletsfknlwadnadavsvqYa

GTGALKTDFTR--QEVLFGAMRDGVNSIVTCFIHIFFS--MQDSIDLFLGNYVVDA
|||||||||||  .. |.||.||||||....... | .  .|||||||||.|.|..
GtgAlKtDftRtGkrtllGalrDgvnsvsryyknnfldgerqdsidLflgkyrvet
Sac_COG5329 52-521 1.7e-122 401.6 In-house 53-538 (1070) alignment 
Range on Protein: 52-521
Range on HMM: 53-538/1070.0
PSADS-VDIFGIMGIIHLLAGPYLIVITKKKLV-GYIQGSEVWKVLQTNVIPFPRATLHLTES----QQYHNK---LYLSMVQSVLQTESFYFSCTYDLT
.|  |   |.|..|.| |    .|||||.|. | . |.| .. |.|.  .|.  .      |.    ......     .|  . .|.. ||||| ..|.|
rslssaheiygvlGlielegslflivitgkskvaqvipgetiykilavdfislnnnkwddeeiesdeasteklrsehpcselkkLlsngsFYfStdfdit

HTLQRLSRTSPEflqmPLYERVDPRFVWNSHLLTPFA----VQPELQ-------RFILPVMHGFISITSCSIKQRSFDFILISRRSCFRAGVRYFMRGLD
 |||. ... .|    . ... | .|.||| ||. .       ..|.       .|. .| .||..  . ..|...    ||||||  ||| |.. ||.|
ntLqkrlkeele....lsvdtadeefmwnsflleelinyrsklsslekqlldnagFlttvIrGFaetvfikvkkktiaLtlISRrSskragtRflarGvD

GEGNAANYVETEQIIQFNTGTSSFVQIRGSIPLYWTQRPNLKYKPKPQVNSSADH-SLGFQYHIDNEIAHYKELVLINLIDQKGPEKVLGDRFSTIIRNS
 .||.||.||||||.. .  . ||.|.|||||..|.|  |. ..|| |.. |.      |. |.|. .  |  ....||...|. |. |  |..  ...|
ddGnvanFVETEqIvyssqycfsFtQvRGSiPiFWeqesnsligpkiqitrsseatqsafdkHFdklfekYGdvhivNLlktKssEieLseryekhlkls

PYKETSYEAFDFHKECSKMRWDRLNLLIDRLSPDQKKFGYFS-MGKDKDIQSEQKGVFRTNCIDSLDRTNVVQSMLARNSLQLQLEEYGVLATGERIvdh
. .....  ||||||.|....|....|.. .  | . |||||  .|.. . |||.|||||||.|.||||||.|.....  |. |.. ..| ....     
ekpkihlteFdfhketsqdgfddvkkLlplieqdllefgyfsydvkegkliseQdGVfRtNClDCLDRTNviQqliskrvlleqfrsikvisaidde...

nDFEYTFKNVWADNADACSVQYAGTGALKTDFTRQ--EVLFGAMRDGVNSIVTCFIHIFF--SMQDSIDLFLGNYvvDANECVSKVCPLQTKRDWR
 ||   ....||||.|| | .| ||||||..|||.    ..||..| ..|.   .|  |.  . ||.|||.|| .  .  | |.. .| ..... |
.dflqklneLWadnGDaisqiYTGtgalkssftrkgkrsiagalsDatkSvsRmyinnfvDkekQdaidllLgkl..pdqeavelydpineyvnlr
subfamily_INPP5F_pd Subfamily INPP5F 53-503 9.3e-116 379.1 In-house 61-509 (951) alignment 
Range on Protein: 53-503
Range on HMM: 61-509/951.0
SADSVDIFGIMGIIHLLAGPYLIVITKKKLVgyiqGSEVWKVLQTNVIPFPRATLH--LTESQQYHnKLYLSMVQSVLQTESFYFSCTYDLTHTLQRLSr
  ..  ..|..|.|.| .  .. .|..|. |     .. |....... . .. . .    |... . |  |  ..  |. .|||.| ..|||.|||. . 
elekeectgliglielegkiivatiegkskv....nnkkwdlididssgylqlkeekeqneeekle.krlleelkkllsdgsFYysldfDltntlqkrg.

TSPEFLQMPLYervDPRFVWNSHLLTPFAVQPELQ--RFILPVMHGFISITSCSIKQRSFDFILISRRSCFRAGVRYFMRGLDGEGNAANYVETEQIIQF
....  ... .   | ||.||..|| ..    . .  .|..||. ||... ..||..  ..  |||||| .||| |.  || | .|| ||.||||.|...
leeksestddw...derFfWNkfllkdlinyrdkldkefltpviqGfvetkeisieklkvsltlisrrSrkragtrfkrrGidddgnvAnfvEtElilsv

NTGTSSFVQIRGSIPLYWTQRpNLKYKPKPQVNSSAD-HSLGFQYHIDNEIAHYKELVLINLIDQKGPEKVLGDRFSTIIRNSPYKETSYEAFDFHKECS
.. . ||.|||||.|..|.|. . |||||.... | .     |. |..... .|...| .||..||. || |...... ....  |.. .  ||||.|.|
ekyvlsftqirGSvPvfweqs.gkkykpkikitrseeetqpaFdehfkeqlkkygkvvivnllsqkssekklskaykeqllkleskdvflikfdfheets

KMRWDRLNLLIDRLSPDQKKFGYFSMGKDKDIQSEQKGVFRTNCIDSLDRTNVVQSMLARNSLQLQLEEYGVLATGERIVDhNDFEYTFKNVWADNADAC
..... .. ||. .  . |..||||. ... . |||||||||||.|.||||||||...... |.||||. |..   ..| | ...  ..|..|||| || 
gekfenvsklielikneikevgyfsydvkekviseqkgvfRtnclDcldrtNvvqqaiskavlelqleklglfepessidd.eellqklkklWadngdai

SVQYAGTGALKTDFTRQ--EVLFGAMRDGVNSIVTCFIHIFFSM--QDSIDLFLGNYVVD
| ||||| ||| |.||.  . |.|.. ||..|.   ..  | ..  |. ||| ||.   .
srqYagtnalkgdltrkgerklaGvlkdgyksvsryylnnfkdkyrqkvidlllGklpkq
Syja_N SacI homology domain 59-352 3.6e-96 313.0 Pfam-A 1-318 (319) alignment 
Range on Protein: 59-352
Range on HMM: 1-318/319.0
IFGIMGIIHLLAGPYLIVITKKKLVGYIQG-SEVWKVLQTNVIPFPRATLHLT------ESQQYHNKLYLSMVQSVLQTESFYFSCTYDLTHTLQRLSRT
..||.|.|.||.. ||.||||.. |..|.|  ...|. ....||..... . .      |... ... .|......|...||||| .||||..||| |..
aygilGlirllsesyllvitkrekvakirgehpiykiksvefiplnseeeessaieeekeeeekeeekllkllkkllssgsfYfSydyDltrslqrksek

SPE-----FLQMPLYERVDPRFVWNSHLLTPF-AVQPELQRFILPVMHGFISITSCSIK-QRSFDFILISRRSCFRAGVRYFMRGLDGEGNAANYVETEQ
. |       ..||...||.|||||..||.|.  ....|.|..||...||....|...| .......||||||. |||.||. ||.| .||.||.|||||
eeeekeeeskslpllkevderFvWNrnllkplielkldlsrwllpliqGfveqrsievkskkkveltLIsRrsvkraGtRylrRGidddGnvANfvEtEq

IIQF--N--TGTSSFVQIRGSIPLYWTQRPNLKYKPKPQVN-SSADHSLGFQYHIDNEIAHYKELVLINLIDQKGPEKVLGDRFSTIIRNS-----PYKE
|...  .    . ||||||||.||.|.| .||..|||.... || ...  |. |... | .|.. |..||...|| || |.... . |..        |.
ivsekkeeskrvfSfvqiRGSvPlfWeqasnlslkpkikitrsseasqkafkkHfkklikrYgkivvvnLlekkgrEkkLseayeelinklnkklkekkk

TSYEAFDFHKECSKMRWD
  |..|||||||......
lkyiefDfhkeckgkkfe
Syja_N SacI homology domain 59-352 3.6e-96 313.0 In-house 1-318 (319) alignment 
Range on Protein: 59-352
Range on HMM: 1-318/319.0
IFGIMGIIHLLAGPYLIVITKKKLVGYIQG-SEVWKVLQTNVIPFPRATLHLT------ESQQYHNKLYLSMVQSVLQTESFYFSCTYDLTHTLQRLSRT
..||.|.|.||.. ||.||||.. |..|.|  ...|. ....||..... . .      |... ... .|......|...||||| .||||..||| |..
aygilGlirllsesyllvitkrekvakirgehpiykiksvefiplnseeeessaieeekeeeekeeekllkllkkllssgsfYfSydyDltrslqrksek

SPE-----FLQMPLYERVDPRFVWNSHLLTPF-AVQPELQRFILPVMHGFISITSCSIK-QRSFDFILISRRSCFRAGVRYFMRGLDGEGNAANYVETEQ
. |       ..||...||.|||||..||.|.  ....|.|..||...||....|...| .......||||||. |||.||. ||.| .||.||.|||||
eeeekeeeskslpllkevderFvWNrnllkplielkldlsrwllpliqGfveqrsievkskkkveltLIsRrsvkraGtRylrRGidddGnvANfvEtEq

IIQF--N--TGTSSFVQIRGSIPLYWTQRPNLKYKPKPQVN-SSADHSLGFQYHIDNEIAHYKELVLINLIDQKGPEKVLGDRFSTIIRNS-----PYKE
|...  .    . ||||||||.||.|.| .||..|||.... || ...  |. |... | .|.. |..||...|| || |.... . |..        |.
ivsekkeeskrvfSfvqiRGSvPlfWeqasnlslkpkikitrsseasqkafkkHfkklikrYgkivvvnLlekkgrEkkLseayeelinklnkklkekkk

TSYEAFDFHKECSKMRWD
  |..|||||||......
lkyiefDfhkeckgkkfe
subfamily_Synaptojanin_pd Subfamily Synaptojanin 57-502 6.5e-82 267.1 In-house 4-438 (754) alignment 
Range on Protein: 57-502
Range on HMM: 4-438/754.0
VDIFGIMGIIHLLA----GPYLIVITKKKLVGYIQGSEVWKVLQTNVIPfpratlhLTESQ--QyhnkLYLSMVQSVLQTESFYFSCTYDLTHTLQrLSR
||..|..|...| |      .|...|  | || |...|..|. .|....       | ..   .     ... .. .|....|||| . | ...|. ||.
vdaygllGvlrlnagdetlsflvlvtgcksvGkisdaeifkitstelvs.......lrseasde....driielkkllasgtfyfsssadsasrld.lsl

TSPEFLQMplyERVDPRFVWNSHLLTPFA-VQPELQRFILPVMHGFISITSCSIKQRSFDFILISRRSCFRAGVRYFMRGLDGEGNAANYVETEQIIQFN
.. .  |    |  | ||.||  | . .   . . ....|.|| | ..|    . ..    .|||| || |||.|. .||.. |||.||.|||||.| ..
saqrrkqe...esednrffWnrslhlhlqrfgvncddWllkvmcGsveirtvyagakqakaalisrlsceraGtrfnvrGvndeGnvanfveteqvilld

TGTSSFVQIRGSIPLYWTQrPNLKY-KPKPQVNSSAD-HSLGFQYHIDNEIAHYKELVLINLIDQKGPEKVLGDRFSTIIRNSPY-KETSYEAFDFHKEC
   .||||||||.||.| | | |.  . | ... . .  .  |. |...  ..| | |..||. .|. |.|| . | .  ..| . |.. .  ||.|...
dkvtsfvqirGsvPlfWeq.PGlqvGshkvklsrgfeasaaafdrhleqlkeryGevvivnllGskegeevlskafkkhlkasehakdvpfvkfdyhqkv

SKMRWDRLNLLIDRLSPD-QKKFGYFSMgKDKDIQSEQKGVFRTNCIDSLDRTNVVQSMLARNSLQLQLEEYGvlaTGERIVDHNDFEYTFKNVWADNAD
   . . |. |...      .....|.. |.|....||.|| |.||.| ||||| ||..|. . |. |||  .    ...    . || .||..|  | |
kggkkeklekllkkqlklflesasffls.kgkevekeqtGvlrvnClDCldrtnavqtvlglevlekqlealk...lsskesvvsrfeevfkslWsknGd

ACSVQYAGTGALKTDFTrqevlFGAMRDGVNSIVTCFIHIFF--SMQDSIDLFL-GNYVV
 .|  |||||||...        . ..||  |..  .   |.  | |..|||.| ||  |
eiskiyaGtgalegkak.....vsklkdgarsvartiqnnfldsskqeaidllllgntyv
subfamily_FIG4_pd Subfamily FIG4 33-515 8.4e-82 266.3 In-house 48-554 (569) alignment 
Range on Protein: 33-515
Range on HMM: 48-554/569.0
EIDRVSQELSLTDNEgqipPSADSVDIFGIMGIIHLLAGPYLIVITKKKLVGYIQGSEVWKVLQTNVIPFPRATLHltESQQYHNKLYLSMVQSVLQTES
|| .. ..|. ....        .|  .||.|....| | |||..||.| |. | |  ..|. ....|. .. . .  .... ... || . ..|  |. 
eikellasleeanrd....glekkvsayGilGfvrflegyylilvtkrkkvaviGghaiykiedialikitedskk..sekssdearylklfkdvdltkn

FYFSCTYDLTHTLQRLSR-TSP-----------EFLQMPLYERVDPRFVWNSHLLTPFAVQPELQRFILPVMHGFISITSCSIKQRSFDFILISRRSCFR
|||| .||||.|||  .  ..            .        . . .||||..|| |.  . .  ...| ..|||.| .. |.  .| . .||.|||   
fyfsysydltrtlqtnlllsdsnrekekaedrvditieakkldanekfvWnnflleplkdtvktfdWlleiihGfvsqskisvlgksiyvtliarrsskf

AGVRYFMRGLDGEGNAANYVETEQII------QF-NTGTSSFVQIRGSIPLYWTQRP-NLKYKPKPQVNSSADHSLGFQYHIDNEIAHYK-ELVLINLID
|| |.. || . .|. ||.||||||.      .. .   |||||.|||.||||.|   .|. ||. ...    .      |.|. . .|   ....||. 
aGarflkrGvnnkGdvaneveteqivheasegsldsdryssfvqlrGsvPlyWsqdasklvtkPpikidvvdPfasaaalhfddlfqryGspiiilnlvk

QK---GPEKVLGDRFSTIIRN-----SPYKETSYEAFDFHKECSKMRWDRLNLLIDRLSPDQKKFGYFSMGKDKDIQSEQKGVFRTNCIDSLDRTNVVQS
.|     |..|   |.. |.       . |. .| ..|...   .   . |. | .  .   || |.|  ..| . .  |.|. ||||.|.|||||. | 
kkekrkresilleefeaaieylneflPeekklkyiswdmaraskskeenvlevlekyaeksvkktGiflsapdlestkiqeGivrtnCvdcldrtnaaqf

MLARNSLQLQLEEYGVLATGErIVDHNDFEYTFKNVWADNADACSVQYAGTGALKTD--FTRQEVLFGAMRDGVNSIVTCFIHIFFS--MQDSIDLFLGN
.... .|. ||.. |...  . .  . |    ..... |  |  ..||.|.   .|   ... . .    || ....   .   |     ||.|.|||| 
vigkvalgyqlkslGiidesk.lefdsdvvrlleelyedlGdtlalqygGsqlvntiktyrkiaqwssksrdiletlkryysnsfvdadkqdainlflGv

YVVdaNECVSKVCPLQ
|.   .| . ..  |.
ysp..reglpslWele
Oxidored_q3 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 522-579 4.9e-06 12.8 Pfam-A 15-70 (144) alignment 
Range on Protein: 522-579
Range on HMM: 15-70/144.0
YMMLPLILLFGFSMFIISVLIpsTDYGIQFLYILFWGAAVLFTLYVVMFFGTEYVDQP
...| ||..| .|..|...|    ..   .|.... || . . |.|.|..  .   ||
tslllliivfimsaliylllg..ssflglililvYvGailiLflfvimlsenketeqp
RdRP_5 Reovirus RNA-dependent RNA polymerase lambda 3 520-550 8.2e-06 9.7 Pfam-A 874-904 (1271) alignment 
Range on Protein: 520-550
Range on HMM: 874-904/1271.0
WRYMMLPLILLFGFSMFIISVLIPSTDYGIQ
. |. ||||||.| . || || .|. | |. 
fvylGlplillpGqtpfitsvympaGdqGlf