Gene LHPP-1 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HAD
Superfamily HAD
Family NagD
Subfamily LHPP
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP095_AA protein Get Run
NvecP095_AA_13-266 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_LHPP_pd Subfamily LHPP 16-244 3.2e-99 322.4 In-house 1-227 (227) alignment 
Range on Protein: 16-244
Range on HMM: 1-227/227.0
VLLDISGVLYNsgkeGGEVIPGSVEALERLKAAGFKVRLCTNETQCTREDLVKKLGRFGYKLSVSEMFAPAPAMRAVLQKRDLRPHFLIHAGGRPDFEGL
||||.||||.|    ....|||.||||.||..||.|||..||.|......||..| |.|......|.|....|.|..|..|.|||..|.... ..|||..
vllDlsGvlhn....edaaipgavealkrLrqagvkvrfvtNttkeskralverLirlgfdveeeeiftsleaarqllrerklrpyllveddveedfedi

NCDNPNCVVIGDAAESFTYESMNTAFRVLLE--NHTLFSMGYGKYY-RTDGqLVLDVGPFAKALEYACDTKAEIVGKPSALFFTTALEDMGVAVQDAIMI
..|.||.||||.|.|||.||..|.|||.|||  ...|.... |||| |.|| |.|..|.|.||||||...|||.|||||||||..|||..||....|.||
dtdkpnavviglapesfeyetlnqafrllleakkakliainkgkyykrkdG.lalgpGafvkaleyatgvkaevvGKPsalffekaleelgvdpeeavmi

GDDIQNDVGGAQAAGIRGVQVRTGKFRPEDEK
|||...||.||..||.|||.|.||||||||||
GDdvedDveGAlkaGlrgvlVktGkfrpedek
Chronophin_1 15-259 1.4e-32 104.2 In-house 3-254 (261) alignment 
Range on Protein: 15-259
Range on HMM: 3-254/261.0
GVLLDISGVLYNsgkeGGEVIPGSVEALERLKAAGFKVRLCTNETQCTREDLVKKLGRFGYK-LSVSEMFAPAPAMRAVLQKRDLRPHFL-IHA-GGRPD
 ||||. |||..    |.|..||  |..|.|| || .|   ||... |||.|...| |.| . ... |.|. | | .|.|.. ... . . . . | | .
lvLlDldGVlik....geeavpgAaeliealkqagkevlfvtNnsrrtreelaarlkrlGldavaaeeifssalaaaallrqqaakakvyvlGeeglrke

--FEGLNCDN-----PNCVVIGdAAESFTYESMNTAFRVLLENHTLFSMGYGKYYRTDGQLVLDVGPFAKALEYACDTKAEIVGKPSALFFTTALEDMGV
   .|| . .     .. ||.|   |....| ...| ... .  ...     ..  ..   .   |  | |.| | .... .||||... | .|||..|.
lreaGlrlvdepedrveaVvvG.ydeelsfeklaeaialirdgalfvatnrDptvPleeGiaPgtGslaaaveaAsgreplvvGKPepvmfeealekiga

AVQDAIMIGDDIQNDVGGAQAAGIRGVQVRTGKFRPEDEKHP--TVKPDGFVDNLAQ
  ....|.|| .. |.  .. ||.. . |.||  ..|. ..    ..||  |...|.
dpeetvmvGDRldTDilagaraglstllvltGvseleeaqaykkdlrPdavvesiad
Hydrolase_like HAD-hyrolase-like 187-260 9.3e-20 61.7 Pfam-A 2-75 (75) alignment 
Range on Protein: 187-260
Range on HMM: 2-75/75.0
VGKPSALFFTTALEDMGVAVQDAIMIGDDIQNDVGGAQAAGIRGVQVRTGKFRPEDEKHPTVKPDGFVDNLAQA
 |||.. ..  |||..|.  ....||||..  |. .|..|||| . |.|| .|.|| |..  ||| .||.|..|
lgKPnpgmydkalevlgappsevvmiGDslatDieaAnnaGirsilVltGvsreedlklakakpdyvvddleea
Hydrolase_6 Haloacid dehalogenase-like hydrolase 16-98 1.9e-18 57.7 Pfam-A 1-79 (101) alignment 
Range on Protein: 16-98
Range on HMM: 1-79/101.0
VLLDISGVLYNsgkeGGEVIPGSVEALERLKAAGFKVRLCTNETQCTREDLVKKLGRFGYKLSVSEMFAPAPAMRAVLQKRDL
.|.|. |||..    | ..|||..|||..|.||| .| |.||... ..|...||| ..|.... .... .| |....|.||. 
flfDvdGvLwr....gdkaipgaaealkalraagkpvvllTNnsskseeeyakkleklgvdvteeqvvtsataaaeylkkrka
subfamily_PGP_pd Subfamily PGP 119-260 4.7e-17 53.2 In-house 129-275 (279) alignment 
Range on Protein: 119-260
Range on HMM: 129-275/279.0
NPNCVVIGdAAESFTYESMNTAFRVLLENHTLFSMGYG-KYYRTDG-QLVLDVGPFAKALEYACDTKAEIVGKPSALFFTTALEDMGVAVQDAIMIGDDI
. ..||.|   | ..|  .  | ..| |.. ||  .   . ..    . . . |....|.| | . |. ..|||. | . . ||   .  . ..|||| .
dvgAVvvg.vdeklsyakllkAanyLrepevlflatneDallplkkevvipgaGslvaaieaasgrkplvlGKPnelllelllekeeidpertlmiGDrl

QNDVGGAQAAGIRGVQVRTGKFRPEDEKHPTV----KPDGFVDNLAQA
. |.  ... |.. . | .|  . || .. .      || ..|.||. 
ktDilfgkncGlqtLlvlsGvtkledveeikkeeklvPdyyldsladl
subfamily_PGP_pd Subfamily PGP 16-98 1.8e-13 41.4 In-house 2-81 (279) alignment 
Range on Protein: 16-98
Range on HMM: 2-81/279.0
VLLDISGVLYNSGKeggeVIPGSVEALERLKAAGFKVRLCTNETQCTREDLVKKLGRFGYK-LSVSEMFAPAPAMRAVLQKRDL
||.|. ||| .. .    .|||..|||..||..| || ..||.   .||.|.||. ..|.. .. .|.. .| |. . |...  
vlfDcDGVlWlget....aipgaaealnaLkklgKkvlfvtNnstksreellkkfkklgfekvkeeeilssaaaiadyLkqkkf
Chronophin_2 123-237 3.2e-11 34.0 In-house 129-244 (282) alignment 
Range on Protein: 123-237
Range on HMM: 129-244/282.0
VVIGdAAESFTYESMNTAFRVLLENHTLFSMGYGKYY--RTDGQLVLDVGPFAKALEYACDTKAEIVGKPSALFFTTALEDMGVAVQDAIMIGDDIQNDV
|..|   |..|.  .  |   | . . |.       .   .||. .   | .. ||| |   || ..||||  .|    ... |    ..|||| .. |.
vlvg.ydekltflklakacaylrdadclllatdrdpwhplsdgritpgsgsltaaletasgrkatvigkpsrfmfecissqfsvdparslmigdrletdi

GGAQAAGIRGVQVRTGK
   .  |.  |   || 
lfgsncglstvltltgv
Chronophin_2 15-88 2.1e-10 31.3 In-house 2-72 (282) alignment 
Range on Protein: 15-88
Range on HMM: 2-72/282.0
GVLLDISGVLYNsgkeGGEVIPGSVEALERLKAAGFKVRLCTNETQCTREDLVKKLGRFGYK-LSVSEMFAPAPA
.||.|  ||..|    | ....|..| ..||. || .| . ||... .||..|.|. |.|.  .   ..|. |  
nvlfdcdgviwn....gekavagapevvsrlaragknvlfvtnnstrarenyvlkfarlgfadvaaeqifssayc
HAD_2 Haloacid dehalogenase-like hydrolase 180-233 1.4e-08 26.5 Pfam-A 127-176 (176) alignment 
Range on Protein: 180-233
Range on HMM: 127-176/176.0
CDTKAeivGKPSALFFTTALEDMGVAVQDAIMIGDDIqNDVGGAQAAGIRGVQV
.|..|    ||.  ..  .||  ||. .....|.| . .|| .|.|||||.|.|
ddvga...pKpdpeayekvlerlgvkpeeilfidDsl.edveaAraaGirtvhv
CECR5_TIGR01456 206-265 5.7e-07 19.2 In-house 301-359 (370) alignment 
Range on Protein: 206-265
Range on HMM: 301-359/370.0
VQDAIMIGDDIQNDVGGAQAAGIRGVQVRTGKFRPEDEkHPTVKPDGFVDNLAQAVGLIV
..   |.||. . |. ||. ||.  . |.|| .  .|| .  .|..  ||.  .||  |.
fkklymvGDnPasDiiGarnaGlfsilvktgvydgade.lkegkarlvvdsvseavikiL
Hydrolase haloacid dehalogenase-like hydrolase 182-227 3.8e-06 18.7 Pfam-A 176-215 (215) alignment 
Range on Protein: 182-227
Range on HMM: 176-215/215.0
TkaeivGKPSALFFTTALEDMGVAVQDAIMIGDDIqNDVGGAQAAG
.     |||.   |  |.| ...  ....|.||.. ||. ...|||
v.....gkPepklfvaaieeLqidpgevamvGDgv.nDapalaaAg