Gene LHPP-2 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HAD
Superfamily HAD
Family NagD
Subfamily LHPP
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP096_AA protein Get Run
NvecP096_AA_6-258 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_LHPP_pd Subfamily LHPP 8-231 1.3e-106 346.6 In-house 1-226 (227) alignment 
Range on Protein: 8-231
Range on HMM: 1-226/227.0
VLVDLSGTIHIENSVIPRSIEALKKLRQTGLPLRFVTNTTKESKLSLLQRLTKIGFDIKADEIFSSLTAAVRLVRTRELRPLLLLQPDAKTDFAGISTDN
||.||||..|.|...||...||||.|||.|. .||||||||||| .|..||...|||....|||.||.||..|.|.|.|||.||...|...||..|.||.
vllDlsGvlhnedaaipgavealkrLrqagvkvrfvtNttkeskralverLirlgfdveeeeiftsleaarqllrerklrpyllveddveedfedidtdk

PNAVVVGLAPDCFNYETLNKAFRLLLD--GGQLIAIHKVQYYKRSDGLVLGPGPFVSALEYATDVQAEVVGKPQALFFKQVLTEIKCDPECAVMIGDDVR
|||||.||||..|.|||||.||||||.  . .||||.| .||||.|||.||||.||.||||||.|.|||||||.||||...|.|...|||.||||||||.
pnavviglapesfeyetlnqafrllleakkakliainkgkyykrkdGlalgpGafvkaleyatgvkaevvGKPsalffekaleelgvdpeeavmiGDdve

NDVEGAQAAGIKGILVKTGKYRHGDE
.|||||..||..|.||||||.|..||
dDveGAlkaGlrgvlVktGkfrpede
Chronophin_1 7-232 3e-39 126.0 In-house 3-237 (261) alignment 
Range on Protein: 7-232
Range on HMM: 3-237/261.0
GVLVDLSGTIHIENSVIPRSIEALKKLRQTGLPLRFVTNTTKESKLSLLQRLTKIGFD-IKADEIFSSLTAAVRLVRTRELRPL--LLLQPDAK--TDFA
 ||.|| | .  .....|   |....|.| |  . |||| ... . .| .||...|.| ..|.||||| .|| .|.|. ...    .| .   .   . |
lvLlDldGVlikgeeavpgAaeliealkqagkevlfvtNnsrrtreelaarlkrlGldavaaeeifssalaaaallrqqaakakvyvlGeeglrkelrea

GISTD-----NPNAVVVGLAPdCFNYETLNKAFRLLLDGGQLIAIHKVQYYKRSDGLVLGPGPFVSALEYATDVQAEVVGKPQALFFKQVLTEIKCDPEC
|. .      ...|||||  . ....| |..| .|. || ...|  . ..  ...| . | |  . |.| |.. .. |||||... |...| .|. ||| 
GlrlvdepedrveaVvvGyde.elsfeklaeaialirdgalfvatnrDptvPleeGiaPgtGslaaaveaAsgreplvvGKPepvmfeealekigadpee

AVMIGDDVRNDVEGAQAAGIKGILVKTGKYRHGDES
.||.|| .  |.. .. ||.. .|| ||  .. . .
tvmvGDRldTDilagaraglstllvltGvseleeaq
subfamily_PGP_pd Subfamily PGP 106-233 4.5e-20 63.1 In-house 128-256 (279) alignment 
Range on Protein: 106-233
Range on HMM: 128-256/279.0
DNPNAVVVGLApDCFNYETLNKAFRLLLDG-GQLIAIHKVQYYKRSD-GLVLGPGPFVSALEYATDVQAEVVGKPQALFFKQVLTEIKCDPECAVMIGDD
 . .|||||.  . ..|  | || . | .   ...|  . . .. ..   . |.|..|.|.| |.. .. |.|||. | .. .|.. . ||| ..|||| 
kdvgAVvvgvd.eklsyakllkAanyLrepevlflatneDallplkkevvipgaGslvaaieaasgrkplvlGKPnelllelllekeeidpertlmiGDr

VRNDVEGAQAAGIKGILVKTGKYRHGDESK
.. |.  ... |.. .|| .| ..  |  .
lktDilfgkncGlqtLlvlsGvtkledvee
Hydrolase_like HAD-hyrolase-like 175-248 2.6e-19 60.3 Pfam-A 2-75 (75) alignment 
Range on Protein: 175-248
Range on HMM: 2-75/75.0
VGKPQALFFKQVLTEIKCDPECAVMIGDDVRNDVEGAQAAGIKGILVKTGKYRHGDESKL-SQPAFgVCQDFLEA
 |||.. .... | . ...|. .|||||..  |.|.|..|||. |||.|| .|..| ..   .|.. |. |..||
lgKPnpgmydkalevlgappsevvmiGDslatDieaAnnaGirsilVltGvsreedlklakakpdy.vvddleea
Hydrolase_6 Haloacid dehalogenase-like hydrolase 8-85 7.9e-19 58.9 Pfam-A 1-78 (101) alignment 
Range on Protein: 8-85
Range on HMM: 1-78/101.0
VLVDLSGTIHIENSVIPRSIEALKKLRQTGLPLRFVTNTTKESKLSLLQRLTKIGFDIKADEIFSSLTAAVRLVRTRE
.|.|. |... ....|| . ||||.||..| |. ..|| ...|. .....|.|.|.|........| |||......|.
flfDvdGvLwrgdkaipgaaealkalraagkpvvllTNnsskseeeyakkleklgvdvteeqvvtsataaaeylkkrk
Chronophin_2 108-225 5.2e-14 43.2 In-house 126-244 (282) alignment 
Range on Protein: 108-225
Range on HMM: 126-244/282.0
PNAVVVGLApDCFNYETLNKAFRLLLDGGQ-LIAIHKVQYYKRSDGLV-LGPGPFVSALEYATDVQAEVVGKPQALFFKQVLTEIKCDPECAVMIGDDVR
 .||.||   . . .  | ||   | |    |.|  .  ..  ||| .  | | . .||| |.  .| |.|||   .|. .  ... ||  ..|||| ..
vravlvgyd.ekltflklakacaylrdadclllatdrdpwhplsdgritpgsgsltaaletasgrkatvigkpsrfmfecissqfsvdparslmigdrle

NDVEGAQAAGIKGILVKTGK
 |.   .  |.. .|  || 
tdilfgsncglstvltltgv
subfamily_PGP_pd Subfamily PGP 8-84 7.9e-14 42.6 In-house 2-79 (279) alignment 
Range on Protein: 8-84
Range on HMM: 2-79/279.0
VLVDLSGTIHIENSVIPRSIEALKKLRQTGLPLRFVTNTTKESKLSLLQRLTKIGFD-IKADEIFSSLTAAVRLVRTR
||.|  |.. .....||...|||..|...|  . ||||   .|.  ||....|.||. .| .||.||  |...  . .
vlfDcDGVlWlgetaipgaaealnaLkklgKkvlfvtNnstksreellkkfkklgfekvkeeeilssaaaiadyLkqk
HAD_2 Haloacid dehalogenase-like hydrolase 175-221 2.2e-10 32.4 Pfam-A 131-176 (176) alignment 
Range on Protein: 175-221
Range on HMM: 131-176/176.0
VGKPQALFFKQVLTEIKCDPECAVMIGDDVrNDVEGAQAAGIKGILV
. ||.  ....|| .. ..|| ...|.| . .|||.|.||||....|
apKpdpeayekvlerlgvkpeeilfidDsl.edveaAraaGirtvhv
Chronophin_2 7-83 5.9e-10 29.9 In-house 2-79 (282) alignment 
Range on Protein: 7-83
Range on HMM: 2-79/282.0
GVLVDLSGTIHIENSVIPRSIEALKKLRQTGLPLRFVTNTTKESKLSLLQRLTKIGF-DIKADEIFSSLTAAVRLVRT
.|| |  | |   . ... . | ...| ..|    |||| .. ..  . ......|| |..|..||||   . ...| 
nvlfdcdgviwngekavagapevvsrlaragknvlfvtnnstrarenyvlkfarlgfadvaaeqifssaycsaaylrd
Hydrolase haloacid dehalogenase-like hydrolase 21-215 2.7e-09 29.1 Pfam-A 127-215 (215) alignment 
Range on Protein: 21-215
Range on HMM: 127-215/215.0
SVIPRSIEALKKLRQTGLPLRFVTNTTKESKLSLLQRLTKigfdikadeifssltaavrlvrtrelrpllllqpdaktdfagistdnpnavvvglapdcf
 | |  .||...|.. |. .  .|.  .|   .  ...                                                              
pvkpeaaeavasLkeaGievvlltgdnpetaeaiakqagi............................................................

nyetlnkafrllldggqliaihkvqyykrsdglvlgpgpfvsaleyaTD--VQAEVVGKPQALFFKQVLTEIKCDPECAVMIGDDVrNDVEGAQAAG
                                               .|  | |||||||.   | ... | . ||. ..|.||.| ||.....|||
...............................................edslvfaevvgkPepklfvaaieeLqidpgevamvGDgv.nDapalaaAg
CECR5_TIGR01456 198-258 1.5e-08 24.5 In-house 305-364 (370) alignment 
Range on Protein: 198-258
Range on HMM: 305-364/370.0
VMIGDDVRNDVEGAQAAGIKGILVKTGKYRHGDESKLSQPAFgVCQDFLEAVELIIKHTKV
 |.||.   |. ||. ||.  |||||| |  .|| |  ..   | ..  |||. |.... |
ymvGDnPasDiiGarnaGlfsilvktgvydgadelkegkarl.vvdsvseavikiLekeav
subfamily_CUT_pd Subfamily CUT 7-92 4.6e-07 19.6 In-house 20-110 (391) alignment 
Range on Protein: 7-92
Range on HMM: 20-110/391.0
GVLVDLSGTIHIENSVIPRSIEALKKLRQT----GLPLRFVTNTTKESKLSLLQRLT-KIGFDIKADEIFSSLTAAVRLVRTRELRPLLLL
|...|. | .  .. |||.  ||||.| .      .|  |.||..  .. .  ..|  |......||... | .    |.   . | |   
givlDiDGvLlRgkkvipaakealklledkkgelkvPvvfltnggnftekekaeklsekLdvevdadqvllshsPlkllaekydkrllvvg
Subfamily.CECR5.protein 7-91 5.2e-07 19.4 In-house 22-111 (393) alignment 
Range on Protein: 7-91
Range on HMM: 22-111/393.0
GVLVDLSGTIHIENSVIPRSIEALKKLRQT----GLPLRFVTNTTKESKLSLLQRLT-KIGFDIKADEIFSSLTAAVRLVRTRELRPLLL
|...|. | .  .. |||.  ||||.| .      .|  |.||..  .. .  ..|  |......||... | .    |.   . | |  
givlDiDGvLlRgkkvipaakealklledkkgelkvPvvfltnggnftekekaeklsekLdvevdadqvllshsPlkllaekydkrllvv