Gene MINPP1-1 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP2
Subfamily MINPP1
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP132_AA protein Get Run
NvecP132_AA_25-441 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_MINPP1_pd Subfamily MINPP1 25-441 1.4e-147 483.9 In-house 5-419 (420) alignment
Range on Protein: 25-441
Range on HMM: 5-419/420.0
NFASKTRYYEPNLEEDIKKEREGGCSAVHMSLVARHGTRNPSKRDVKKIQRTTEAIDQLFSGHP--VKIGNLTIPSPSLFTENMDKDLIEIGREELYNMS
 ..|||.||. . ..|||||.| ||..|.....||||||.|||...||||.|.|.|..  . .    .| | .. |.. ......|.|.. |.|||....
flgsktpyysvkanydikkeaeegCklvklqiiaRHGtRypskskikkiqetlekiknyseqldgklsilnedlesnleyetelekslvaqgqeeleela

RRVKQRYPELFNVEMLKEKIRFVSTRTARSIQSAHAFALGLlgrplVPIAMVTDIDKDPITIETHDKDNDPVLRYFDVCPKYIHQVSKNKTSLYEHHEFK
.|...|.|.||.... .....|.||...|...||.||| ||     .. ..|.... .....|......|..||.|| |.||...|.||...|.|..||.
krlarrfpalfeevynpdsfsfastakkRtvksaqaFaeGL.....setgevlgdefnivlqeiseqesdklLrffdsCkkyknkvkknelnlkeeeefl

NSSAMRTVVEHVRDLF-NLQGSEIIHVKHVIGMYLACTFEVAVYNRSDSWCSVFRPSDLDVLEYFYDLKHYWKRGYGYKITYEISCVLLKNIINTIKTAV
.|.......|.... . . . . ... |..  |. .|..|.|....|..|||.|....| .|||. |||.|.|.||||.|.|.||| ||..|....|...
eskelqkaleeiakrlneekklleltekdiedmfeiCayelaikgisnvWcslfekdelleleYledLknyykegyGyeinysiscpLlndivkllksse

LSDNKNGPignFMFAHAETIQPLNALLGLFKDVMPLRADNYHRHKNRKYRASQISPFGANIAFTVYNC-SGLYQIQVLSNEKIVSLPCC-EGPR-CPLQR
 ...|...   ..||||||..|| .||||.|| ..|.|.|||...|||.|.|.|.|..||.||..|.| .. |...|| |||.|.|..| ||.. |.||.
eqkqksss...lrFaHaetllpllsllGlykDeekLtannyhklsnrkfrssvivpyaanlafvlydCskdqykvlvllnekvvkletcsegeifCelqd

FFDCFSEVYNMCDLKALCELDKK
|..........|||..|||..|.
fkeiykkivdncdleklCevskv

0048946 Phosphoglycerate mutase-like 38-441 4.1e-72 236.4 In-house 28-414 (447) alignment
Range on Protein: 38-441
Range on HMM: 28-414/447.0
EEDIKKEREGGCSAVHMSLVARHGTRNPSKRDVKKIQRTTEAIDQL----FSGHPVKIGNLT-IPSPSLFTENMDKDLIEIGREELYNMSRRVKQRYPEL
.  | .    ||  ... .. |||.| |.|   |... . . ...     ..|.   . . .  .... . .    .| . |||.||.. .| ..||. |
gygipepvpegcelkqvqvlfRHGaRtPtkkylkgleplldllknanvlelggdlsflndwkyqlkneplwpcglgqLTplGreqlyelGkrlrkrYlgl

FNvemLKEKIRFVSTRTARSIQSAHAFALGLLGRPlvpiamvTDIDKDPITIETHDKDNDPVLRYfdVCPKYIHQVSKNKTSLYEHheF-KnssamrTVV
..    ...| . |. . | .||| ||. ||..         ....  ||.| | ...||..|.    ||.. ... |. .. ...  . |       . 
lp...npseiyvrssdvdRtlqSaqaflaGlfppe.......pplgyqpipihtvpssndnlllp..sCpafkellkkelaeelke..llk......ell

EHVRDLFNlqgSEIIHVKHVIGMYLACTFEVAVYNRSDsWCSVFRPSDLDVLEYFYDLKHYWKRGYGYKITYEISCVLLKNIINTIKTAVLSDNkngpIG
| . .|..      . ...|  .| .. .| |....|. .||.| |..|.||||..||..|.. |||..... ....||..|.. .. |. .|.      
erlkkllg...glnltlsdvydlydlllyetaihglsp.lcslftpeelevleyladlefyyeygygdelarlaggpllneilarledaisgds....kl

NFMFAHAETIQPLNALLGLFKDVMPLRADNYHRhkNRKYRASQISPFGANIAFTVYNC------SGLYQIQVLSNEKIVSLPCCEGP---RCPLQRFFDC
.. ||| .||..| ..||||.| .|| |||.    ||..|.|.|.|...|..| .|.|      .| | ..|| |.. . ||.|..     |||..| ..
ylyfaHdttiaallsaLglfddelplpadnlpf..nrlfrsseivPyasnlvfElyecpsslpsdgeyyVrvlyngeplplpgCgsgpgglCplddFkel

FSEVYNmcDLKALCELDKK
 ... .  | . ||.|...
lkkflp..dweklCgltls

0049059 Phosphoglycerate mutase-like 26-436 1.3e-67 221.6 In-house 18-434 (435) alignment
Range on Protein: 26-436
Range on HMM: 18-434/435.0
FASKTRYYEPNLEEDIKKEREGGCSAVHMSLVARHGTRNPSKRDVKKIQRTTEAIDQLFSGHPvkiGNLTIPSPSLFTENMdKDLIEIGREELYNMSRRV
.. ...|..     .|  .   ||  ... ...|||.| | .   ||.. . | . .|.  .    |.|..     .. ..  .| . |||..|.. .| 
lgtlspyfsapgvfgisldvpegcelkqvqvlfRHGaRtPtsklikklealwekllslltypn...gplsflndwnyplga.geLTplGreqayelGkrl

KQRYPELfnveMLKEKIRFVSTRTARSIQSAHAFALGLLGRPLVPIAMVTDI-DKDPITIETHDKDNDPVlrYFDVCPKYIHQVSKNKTSlyehHEFKNS
 .||. |    . ...... |. . | .||| ||. ||..  .... .. .  ...|. ||| | ||| .   .| ||.. ........|    .||.. 
rkrYgfL....ynpdevyvrssdvdRtlqSaqaflaGlfppeilgsqllnplnvyqpvpietvdsdndtl..pydscpafdellkellas....deflel

SaMRTVVEHVRDLFNLQGseiIHVKHVIGMYLACTFEVAVYNRS----DSWCSVFRPSDLDVLEYFYDLKHYWKRGYGYKITYEISCVLLKNIINTIKTA
  .. . .  ..|..  |   . .. |  .|  | .........     ..||.| ...|.||||..|| .|.  |||..|.. ....||. |.. .. |
f.lerilkllqellpglg...ltpsdvldlydlckydtlllgyahglplpfcslfteeelevleyladlefyylygygdeiaklaggpllneilarleda

VLSDNKN--------------GPIGNFMFAHAETIQPLNALLGLFKDVMPLRADNYHRHK-NRKYRASQISPFGANIAFTVYNCSG--LYQIQVLSNEKI
. .|. |              ..   . ||| .||.|| ..||||.| .|| |||.  .. .|..|.|.|.|...|..| .|.|..   | ..|| |.| 
ingdstnlnltldsnpatfpldlklylyfaHdttiapllsaLglfddqlplpadntpfpeldrlfrtseivPyasnlvfElyecpdgneyyVrvlyngkv

VSLPCCEGP---RCPLQRFFDCFSEVYNMCDLKAlC
. ||.|..    .|||. | .. ... . .| .  |
lplpgcgsgpgglCplddFkelvkkflpgddfde.C

0047369 Phosphoglycerate mutase-like 26-437 1.5e-66 218.3 In-house 19-437 (438) alignment
Range on Protein: 26-437
Range on HMM: 19-437/438.0
FASKTRYYEPNLEEDIKKEREGGCSAVHMSLVARHGTRNPSKRDVKKIQRTTEAIDQLfsghpvkignLTIPSPSL-------FTENMdKDLIEIGREEL
.. ...|.. .    |  .   ||  ... ...|||.| |.|   ||.. . | ...            |.||..|       .. ..  .| . |||..
lgtlspyfsapgvglisldvpegcelkqvqvlfRHGaRtPtksklkkleplwellena..........ttypsgplsflndwlgpcga.gqLTplGreqa

YNMSRRVKQRYPELfnvemLKEKI-RFVSTRTARSIQSAHAFALGLLGRPLVPIAMvtDIDKDPITIETHDKDNDPVLR--YFDVCPKYIHQVSKNKTSl
|.. .|  .||. |       |.. .. |. . | .||| ||. ||..  . ..    .|  .||.|.|  ...|..|.  ..| ||.. . ......| 
yelGkrlrkrYglL.....npedvlyvrssdvdRtlqSAqaflaGlfppegtgela..pilwqpipihtipesddfllnllpsdscpafdellkeflas.

YEHHEFKnssaMRTVVEHVRDLFNLQGseiIHVKHVIGMYLACTFEVAVYNR----SDSWCSVFRPSDLDVLEYFYDLKHYWKRGYGYKITYEISCVLLK
 |  |..    .. . . ...|..  .   .... |. .|  |... ....       ..||.| |..|.||||..||..|...|||..... ....||.
deflell....lkdilkrlkkllpgln...ltpsdvldlydlcaydtlangyaglplspfcslftpeelevleyladlefyylygygnelaklaggplln

NIINTIKTAVLSDNKN--------------GPIGNFMFAHAETIQPLNALLGLFKDVMPLRADNYH-RHKNRKYRASQISPFGANIAFTVYNCS--GLYQ
.|.. .. |. ... |              ..   . ||| .||..| ..||||.|  ||. ...     ||..|.|.|.|...|..| .|.|.  | | 
eilarledaingkstnlnltldsngvtfPldlklylyfaHdttiaallsaLglfddtwplpglpldkialnrlfrsseivPyasnlvfElyecpsdgeyy

IQVLSNEKIVSLPCCEGP---RCPLQRFFDCFSEVYNMcDLKALCE
..|| |.| . ||.|..     |||..| .. ... .  | . ||.
VrvlyngkvlplpgcgsgpgglCplddFkelvkkllpg.dfeelCg

0049226 Phosphoglycerate mutase-like 53-436 2.4e-60 197.5 In-house 5-340 (342) alignment
Range on Protein: 53-436
Range on HMM: 5-340/342.0
HMSLVARHGTRNPskrdvkkiqrtteaidqlfsghpVKIGNLTIPsPSLFTENMDKDLIEIGREELYNMSRRVKQRYPELFNVEMLKEKIRFVSTRTARS
.. ...|||.| |                       .. |.|.   .  | .... .| . |||..|.. || ..||..|..  . .... . |. . | 
qvqvliRHGdRtP.......................lakgpldfl.newfwgcglgeLTplGreqayelGrrlrkrYlgllpstynpdevyvrssdvdRt

IQSAHAFALGLLGRPLVPIaMVTDIDKDPITIETHDKDNDPVLRY-FDVCPKYIHQVSKNKTSlyEHHEFKNSSamrtVVEHVRDLFNLQGSEIIHVKHV
.||| ||. ||..  | || .|...|  ||.|.| ...||..|.. .| ||.. ........|  |. .  ...      . ...|..| | ...  ..|
lqSaqaflaGlfppeltpi.lvplldwqpipiitepesndtllllpydscpnfdkllkellks..eevqlflee....ildllkklskllglnlstlsdv

IG-MYLACTFEVAVYNRSDSWCSVFRPSDLDVLeYFYDLKHYWKRGYGYKITYEISCVLLKNIINTIKTAVLsdNKNGPIGNFMFAHAETIQPLNALLGL
.  .|  ...|.|      .|||.| . .| .| |..||..|. .|||..|.. ....||..|.. .. |.   .....  .. ||| .||..| ..|||
adtlydlllyelahglplppwcslftleelkal.yaldllyyygigygeeiarlaggpllneilarleeaie..gpsdlklylyfahdttiaallsalgl

FKDVMPlradnyhrhknrkyrasqisPFGANIAFTVYNCSGLYQIQVLSNEKI------VSLPCCEGPrCPLQRFFDCFSEVYNMcDLKALC
|.| .|                    |...|..| .|.|.| | ..|| |...      . || |.|  |||..| .......   | . ||
fddqlP....................pyasnlvfElyecdgeyyVrvlynggvlslpvtlplpgcdgl.cpldefkelvkkflpg.dfeelC

0046349 Phosphoglycerate mutase-like 48-440 3.8e-60 197.1 In-house 4-394 (409) alignment
Range on Protein: 48-440
Range on HMM: 4-394/409.0
GCSAVHMSLVARHGTRNPSKR-----DVKKIQRTteaidqlfsghpvkignltipspslFTENMDKDLIEIGREELYNMSRRVKQRY--PELFNVE--ML
||  ... ...|||.| | |      ..  | .|                         . .  . .| . |||..|.. .| ..||  . |.. .  . 
gceLkqvqvlfRHGaRtPtkklsflpnwpginwt.........................ngpcgagqLTplGreqayelGkrlrkrYvdlgLlpsnslyn

KEKIRFVSTRTARSIQSAHAFALGLLGRPLVPI-----AMVTDIDKDPITIETHDKD-----NDPVLRYFDVCPKYIHQVSKNKTSLYEHHEFK------
...|...|. . | .||| ||. ||..   ..|      .. |.  .||.| | . .     .| .|.... ||.. . ...|..|| |  ||       
pdeiyvrssdvdRtlqSAqaflaGlfpplggeivpllrqdlldppfqpipidtvpiseddalddtllppdslcpaldkllkenlkslsevleflvdeall

---NSSAMRTVVEHVRDLFNLQ--GSEIIHVKHVIG-MYLACTFEVAVYNRSDSWCSVFRPSDLDVLEYFYDLKHYWKRGYGyKITYEISCVLLKNIINT
    .... .... . . .|..  | .......|.  .| ....| |      .||..| |..|.||.|..||  |. .|.| .... ....||. |.. 
dlelldetkdllkklaerlnselpglnltdpldvasllydtllyetahglplppwcdlftpeelkvlayladleyyylygsg.elaklaggpllneilar

IKTAVLSDNKN----GPIGNFMFAHAETIQPLNALLGLfkdvmplradnyhrhKNRKYRASQISPFGANIAFTVYNC--SGLYQIQVLSNEKIVSLPCCE
.. |. ..| .    ..   . ||| .||..| ..|||               ..|..| |.| |...|..| .|.|  .| | ..|| |.. . || | 
ledaisgknpvtfpldlklylyfaHdttiaallsaLgl...............fdrlfrssdippyasnlvfElyecpsdgeyyVrvlynggplplpgcg

GPrCPLQRFFDCFSEVYNMC---DLKALCELDK
 . |||..| ...... . |   | . ||.|..
eg.cplsefkellkkrlpgcgltdfdklCpled

0053031 Phosphoglycerate mutase-like 53-436 8.2e-56 182.8 In-house 5-340 (342) alignment
Range on Protein: 53-436
Range on HMM: 5-340/342.0
HMSLVARHGTRNPskrdvkkiqrtteaidqlfsghpVKIGNLTIPSPSLFtENMDKDLIEIGREELYNMSRRVKQRYPELFNVEMLKEKIRFVSTRTARS
.. ...|||.| |                       .  |.|.      .    . .| . |||..|.. || ..||..|..  . ...... |. . | 
qvivlvRHGaRtP.......................lskgpldplnewfy.pcgageLTplGreqayelGrrlrkrYlgllpstynpdevyvrssdvdRt

IQSAHAFALGLLGRPLVPIAmVTDIDKDPITIETHDKDNDPVLRY-FDVCPKYIHQVSKNKTSLyEHHEFKNssAMRTVVEHVRDLFNLQGSEIIHVkhV
.||| ||. ||..    ||  .....  ||.|.| ....|..|.. .| ||.. . ......|  |. |...   .. ... . . ..|  |   ..  |
lqSAqaflaGlfppegtpil.npllgwqpipihtepessdalllpnydpcpafdkllkealase.evkelle..rylellqklskglgltlsdlldl..v

IGMYLACTFEVAVYNRSDSWCSVFRPSDLDVLeYFYDLKHYWKRGYGYKITYEISCVLLKNIINTIKTAVLSdnKNGPIGNFMFAHAETIQPLNALLGLF
. .| .. .|.|. .   .||..| . .| .| |..||..|.. |.|..... ....||..|.. .. .. .  ....   . ||| .||..| ..||||
sdlydlllyelahglplppwctlftleelkal.yaldllyyyglgpgnelaklaggpllneilarleekisg..pldlklylyfahdttiaallsaLglf

KDVMPlradnyhrhknrkyrasqisPFGANIAFTVYNCSGLYQIQVLSNEK------IVSLPCCEGpRCPLQRFFDCFSEVYNMcDLKALC
.| .|                    |...|..| .|...| | ..|| |..       . || |.|  |||..| .......   | . ||
ddqlP....................pyasnlvfElyedpgeyyVrvlynggtlseplvlplpgcdg.lcplsefkelvkkllpg.dfeklC

0048439 Phosphoglycerate mutase-like 48-425 8.2e-48 156.6 In-house 6-388 (391) alignment
Range on Protein: 48-425
Range on HMM: 6-388/391.0
GCSAVHMSLVARHGTRNPSKRDVKKIQRTTEAidqlfsghpvkignltipsPSLFTENMDKDLIEIGREELYNMSRRVKQRY--PELFNVEM--LKEKIR
||  ... ...|||.| | .   .|.. ...                      .. . .. .| . |||.||.. ||  .||  . |..  .   .... 
gcelkqvqvlfRHGaRtPtssypnkldpllnk...................llpngpcglgeLTplGreqlyelGrrlrkrYvdlgllpskytlnpsevy

FVSTRTARSIQSAHAFALGLLGRplvpiamvtdiDKDPITIETHDKDNDPVLRYFDVCPKYIHQVSKNKTSLYEHHEF----------------------
. |. . | .||| ||. ||..             .... .    .. ||.|   ...    .... ... | .   |                      
vrssdvdRtlqSAqaflaGlfpp...........lgltvilvivvesedpllnplpintcplledlllldalsalprfylseilerlaevlnrvlglnlt

KnssamrtvvehvrdlfnlqgseiihvKHVIGMYLACTFEVAVYNRS----DSWCSVFRPSDLDVLEYFYDLK-------------------------HY
                           . |....  | .|.|..        ..|..|   |  ..||...|.                          |
a..........................edvlslfdlcaketaalgsllklssplcdlftlydtllyeyahglplpewltdellspellkqladlvnelyy

WKRGYGyKITYEISCVLLKNIINTIktavLSDNKNGPIGNFMFAHAETIQPLNALLGLFKDVMPLRADNyhrhknrkyrasqiSPFGANIAFTVYNC--S
.  |.| .|.. ....||..|.. .      .....|  .. ||| .||..| ..||||.|  ||.||.               |...|..| .|.|  .
yltgsg.eiaklaggpllneilddl....vangpsdpklylyfaHdttiaallsaLglfndtlplpadl..............ppyasnlvfElyecpsd

GLYQIQVLSNEK--------------------IVSLPCCEGP---RCPLQRFFDCFSE
| | ..|| |..                     . || |..     |||..| .. ..
geyyVrvlynggtldlprdltlldldefllrlvlplpgcgsgpgglCplddFvelvkk

His_Phos_2 Histidine phosphatase superfamily (branch 2) 54-397 9e-32 103.3 Pfam-A 5-344 (347) alignment
Range on Protein: 54-397
Range on HMM: 5-344/347.0
MSLVARHGTRNPSKRDVKKIQ----------RTTEAIDQLFSGHPVKignltipSPSLFTENMDKdLIEIGREELYNMSRRVKQRYPELFNVEMLKEKIR
. .| ||| | | .   |...          ...   .. |.|  .|          ...  ... |   ||...... ....||||.|.. .. .|.. 
vvvviRHGdRtPkqkfkksvtsekfisllklknvlekkghfpgtkrk.......eklqlilkwgg.lThsGrkqaeelGeqlrqrYpgllrdhltyedvk

FVSTRTARSIQSAHAFALGLLGRPL--VPIAMVTDIDKDPITIETHDK---DNDPV-LRYFDVCPKYIHQVSKNKTSLYEHHEFKNSSAMRTVVEHVRDL
. |.   | ..||.||| ||||              |  .. . | |.    .... ..  . ||..  ...|...   |. .. ..     . . . .|
irssserRvlaSAqafaaGllgpegelllsirkdllddsnaakdtmdevkkklkellregaescpafawppikvekrvvelvnklkkvmdenlakrlsal

fnLQGSEIIHVKHVIGMYLACTFEVAvYNRSDSWCSVFRP--SDLDVLEYFYDLKHYWKR-GYGYKITYEISCVLLKNIINTIKTAVLSDN-KNGPIGNF
  ..| . .  | .   . .. ||   ..    .....     |.  .... ||. ..|  |.| ..  .|   ||..... |. ..  .. ..     .
..ctgednllfkerweklfreffeee.kfdiskipelydtmkydalhnrqledleelyklygigdeeklkigllllnpllkkilsdleetqpsrhaklrl

MFAHAETIQPLNALLGLFKDVMPLradnyhrhknrkyrASQISPFGANIAFTVYNCSGL-YQIQV
 |.| ..| .| ..|||...  ..              ||.  |....| | .| .|.  . ...
yfthDshiytllnaLgleekiare..............aspelpyasqivfelyedsekkfyvrl

His_Phos_2 Histidine phosphatase superfamily (branch 2) 54-397 9e-32 103.3 In-house 5-344 (347) alignment
Range on Protein: 54-397
Range on HMM: 5-344/347.0
MSLVARHGTRNPSKRDVKKIQ----------RTTEAIDQLFSGHPVKignltipSPSLFTENMDKdLIEIGREELYNMSRRVKQRYPELFNVEMLKEKIR
. .| ||| | | .   |...          ...   .. |.|  .|          ...  ... |   ||...... ....||||.|.. .. .|.. 
vvvviRHGdRtPkqkfkksvtsekfisllklknvlekkghfpgtkrk.......eklqlilkwgg.lThsGrkqaeelGeqlrqrYpgllrdhltyedvk

FVSTRTARSIQSAHAFALGLLGRPL--VPIAMVTDIDKDPITIETHDK---DNDPV-LRYFDVCPKYIHQVSKNKTSLYEHHEFKNSSAMRTVVEHVRDL
. |.   | ..||.||| ||||              |  .. . | |.    .... ..  . ||..  ...|...   |. .. ..     . . . .|
irssserRvlaSAqafaaGllgpegelllsirkdllddsnaakdtmdevkkklkellregaescpafawppikvekrvvelvnklkkvmdenlakrlsal

fnLQGSEIIHVKHVIGMYLACTFEVAvYNRSDSWCSVFRP--SDLDVLEYFYDLKHYWKR-GYGYKITYEISCVLLKNIINTIKTAVLSDN-KNGPIGNF
  ..| . .  | .   . .. ||   ..    .....     |.  .... ||. ..|  |.| ..  .|   ||..... |. ..  .. ..     .
..ctgednllfkerweklfreffeee.kfdiskipelydtmkydalhnrqledleelyklygigdeeklkigllllnpllkkilsdleetqpsrhaklrl

MFAHAETIQPLNALLGLFKDVMPLradnyhrhknrkyrASQISPFGANIAFTVYNCSGL-YQIQV
 |.| ..| .| ..|||...  ..              ||.  |....| | .| .|.  . ...
yfthDshiytllnaLgleekiare..............aspelpyasqivfelyedsekkfyvrl

subfamily_ACP2_pd Subfamily ACP2 55-439 1e-24 79.8 In-house 13-359 (361) alignment
Range on Protein: 55-439
Range on HMM: 13-359/361.0
SLVARHGTRNPSKrDVKKIQrtteaidqlfsghpvkignltIPSPSlFTENMdKDLIEIGREELYNMSRRVKQRYP---ELFNVEMLKEKIRFVSTRTAR
... ||| |.|.. . .. .                     . ... .....   | | | .. |.. .  ..||    .... .. ...| . |. . |
qvlfRHGdRsPln.typndk.....................ykede.wpqgl.GqLTeeGmqqqyeLGkfLrkrYvedtkfldakynpkqiyvrSsdvnR

SIQSAHAFALGLLGRpLVPIAMVTDIDKDPITIETHDKDNDPVLRYFDVCPKYIHQVSKNKTSlyehHEFKNSSA---MrtvveHVRDLFNLQGSEIIHV
 ..|| ... ||..     ..  ....  |. . | ....|..|| .  ||.| . ... |.|     |.|.             .. | .  | .| . 
TlmSaqsvlaglfpp.etgvdypdeqeWqpvPvhtvseeedlllrakknCprydellqeakes....pevkklleenke.....lleklsestgedidle

KHVIgMYLACTFEVAVYN--RSDSWCS-VFrPSDLDVLE-YFYDLKHYWKRGYGYKITYEISCVLLKNIINTIKTAVLSDNKNGPIGNFMF-AHAETIQP
. .  .. .   | . .|    ..| .  .  ..|. |. ... .. . .  .  ..    . .||..... .|...  ..|.     |.. || .|. .
nfyq.lsdtlicerkyanelnlpewandel.fekleeladkvkeaefglnnektrelkklrgGpllnellenmkeklkceekkkklklflYSaHDttlaa

LNALLGLFkdvmplradnyhrhknrkyrASQISPFGANIAFTVYN-CSGLYQIQVLSNEKIVS------LPCCEG-PRCPLQRFFDCFSEvYNMCDLKAL
| ..||.|                      .. |. . |.. .|.  .| . ..|| ...  .      || |.|  .|||..|...... . . |.. |
lLeaLgif....................ekkappyasaiivElyeeddgkplvkvlyrnetskdppeltlpgCkgeedCplskfkkivkp.fipddvdel

CELD
|| .
Ceak