Gene PHO3 in Saccharomyces cerevisiae

Synonym: YBR092C, PHO3

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP2
Subfamily MINPP1
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP003_AA protein Get Run
ScerP003_AA_32-460 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_MINPP1_pd Subfamily MINPP1 36-443 6.2e-148 485.1 In-house 1-419 (420) alignment 
Range on Protein: 36-443
Range on HMM: 1-419/420.0
DIFPFLGGAGPYFSFPGDYGISRDLPEGCEMKQLQMLARHGERYPTYSKGATIMKTWYKLSNYTRQFNGSLSFLNDDYEffirddDDLEMETTFANSDNV
....|||...||.|....|.|.....|||....||..||||.|||. ||  .|..|..|..||..|..|.||.||.|.|      ..||.||....| ..
elvkflgsktpyysvkanydikkeaeegCklvklqiiaRHGtRypskskikkiqetlekiknyseqldgklsilnedle......snleyetelekslva

LNPYTGEMDAKRHAREFLAQYGyMFENQTSFPIFAASSERVHDTAQYFIDGL-------GDQFNISLQTVSEAMSagANTLSAGNACPGWDEDANDDILD
 .....|. |||.||.|.|... . .|..|| .. ....|....||.|..||       ||.|||.||..||..|  ...|.. . |. .........| 
qgqeeleelakrlarrfpalfe.evynpdsfsfastakkRtvksaqaFaeGLsetgevlgdefnivlqeiseqes..dklLrffdsCkkyknkvkkneln

KYDT----------TYLDDIAKRLNKENKGLNLTSKDANTLFAWCAYELNARGYSDV-CDIFTEDELVRYSYGQDLVSFYQDGPGYDMIRSVGANLFNAT
....          ..|..||||||.|.|.|.||.||....|..|||||...|.|.| |..|..|||....| .|| ..|..|.||....|....|.|..
lkeeeefleskelqkaleeiakrlneekklleltekdiedmfeiCayelaikgisnvWcslfekdelleleYledLknyykegyGyeinysiscpLlndi

LKLLKQSETQDLKVW-LSFTHDTDILNYLTTAGIIDDKNNLTA-EYVPFMGNTFHKSWYVPQGARVYTEKFQCSNDTY-VRYVINDAVVPIETCSTGPGF
.||||.||.|. |.. |.|.|....|..|...|...|...||| .|.... ..|..|..||..|........||.|.| |....|..||..||||.|..|
vkllksseeqkqkssslrFaHaetllpllsllGlykDeekLtannyhklsnrkfrssvivpyaanlafvlydCskdqykvlvllnekvvkletcsegeif

sCEINDFYDYAEKRVAGTDFLKVCNVSSV
 ||..||.....|.|...|. |.|.||.|
.CelqdfkeiykkivdncdleklCevskv
0048946 Phosphoglycerate mutase-like 34-460 9.8e-93 304.3 In-house 10-430 (447) alignment 
Range on Protein: 34-460
Range on HMM: 10-430/447.0
QEDIFPFLGGAGPYFSFPGdYGISRDLPEGCEMKQLQMLARHGERYPTYSKGATIMKTWYKLSNYTR-QFNGSLSFLNDDyEFFIRDDDDLEmettfaNS
. .|...||.  ||||.|| |||. ..||||| ||.|.| |||.|.||.. . ........| |..   ..|.||||||. . .....   .        
gfnillhlgtlspyfsvpg.ygipepvpegcelkqvqvlfRHGaRtPtkkylkgleplldllknanvlelggdlsflndw.kyqlkneplwp......cg

DNVLNPyTGEMDAKRHAREFLAQYGYMFENQTSFPIFAASSERVHDTAQYFIDGLGDQF---NISLQTVSEAMSAGANTLSAgnACPGWDEDANDDILdK
 . | | .|  ..  . . .   |.  . |.. . ... ...|....||.|. || ..    .. . .. ...| . |.|     || ..|. .. .  .
lgqLTp.lGreqlyelGkrlrkrYlgllpnpseiyvrssdvdRtlqSaqaflaGlfppepplgyqpipihtvpssndnlllp..sCpafkellkkela.e

YDTTYLDDIAKRLNKENKGLNLTSKDANTLFAWCAYELNARGYSDVCDIFTEDELVRYSYGQDLVSFYQDGPGYDMIRSVGANLFNATLKLLKQSETQDL
.  ..|.....||.| ..||||| .|...|. ...||....|.|. |..||..|| .. | .||. .|  |.|... | .|  |.|. |. |..   .| 
elkellkellerlkkllgglnltlsdvydlydlllyetaihglsplcslftpeelevleyladlefyyeygygdelarlaggpllneilarledaisgds

KVWLSFTHDTDILNYLTTAGIIDDKNNLTAEYVPFmGNTFHKSWYVPQGARVYTEKFQC------SNDTYVRYVINDAVVPIETCSTGPGFSCEINDFYD
|..|.|.|||.|.. |.. |. ||.  |.|...|| ...|. |..|| ......|...|      ....|||...|....|.. |..|||..|. .|| .
klylyfaHdttiaallsaLglfddelplpadnlpf.nrlfrsseivPyasnlvfElyecpsslpsdgeyyVrvlyngeplplpgCgsgpgglCplddFke

YAEKRVAgtDFLKVCNVsSVSNVTELTFYWDWNTTHY
. .|..   |. |.|.. . |. ..|....|......
llkkflp..dweklCgl.tlsvlallsvlidvllltl
0049059 Phosphoglycerate mutase-like 33-439 4.2e-86 282.5 In-house 10-435 (435) alignment 
Range on Protein: 33-439
Range on HMM: 10-435/435.0
TQEDIFPFLGGAGPYFSFPGDYGISRDLPEGCEMKQLQMLARHGERYPTYSKGATIMKTWYKLSNYTRQFNGSLSFLNDdYEFFIRddddlemettfans
.. .|. .||. .||||.|| .||| |.||||| ||.|.|.|||.|.||.. . .. ..| || .... .||.|||||| .....               
dgfnillllgtlspyfsapgvfgisldvpegcelkqvqvlfRHGaRtPtsklikklealwekllslltypngplsflnd.wnyplg..............

DNVLNPyTGEMDAKRHAREFLAQYGYMfENQTSFPIFAASSERVHDTAQYFIDGLGDQF----------NISLQTVSEAMSAGANTLsAGNACPGWDEDA
.. | | .|  .|..... . . || .  |.. . ... ...|. ..||.|. || ..           |. .... |..... .||   ..|| .||  
ageLTp.lGreqayelGkrlrkrYgfL.ynpdevyvrssdvdRtlqSaqaflaGlfppeilgsqllnplnvyqpvpietvdsdndtl.pydscpafdell

NDDIL-DKYDTTYLDDIAKRLNKENKGLNLTSKDANTLFAWCAYELNARGY-----SDVCDIFTEDELVRYSYGQDLVSFYQDGPGYDMIRSVGANLFNA
....  |.. ...|..|.|.|.. ..||.|| .| ..|...|.|.. ..||     .. |..|||.|| ...| .||. .|. |.|... . .|  |.|.
kellasdeflelflerilkllqellpglgltpsdvldlydlckydtlllgyahglplpfcslfteeelevleyladlefyylygygdeiaklaggpllne

TLKLLKQSETQ------------------DLKVWLSFTHDTDILNYLTTAGIIDDKNNLTAEYVPFM--GNTFHKSWYVPQGARVYTEKFQCSN--DTYV
 |. |..   .                  |||..|.|.|||.|.. |.. |. ||.  |.|...||.  ...|. |..|| ......|...|..  ..||
ilarledaingdstnlnltldsnpatfpldlklylyfaHdttiapllsaLglfddqlplpadntpfpeldrlfrtseivPyasnlvfElyecpdgneyyV

RYVINDAVVPIETCSTGPGFSCEINDFYDYAEKRVAGTDFLKvCN
|...|..|.|.. |..|||..|. .|| .. .|.. | || . |.
rvlyngkvlplpgcgsgpgglCplddFkelvkkflpgddfde.Cg
0047369 Phosphoglycerate mutase-like 33-440 6.6e-86 282.1 In-house 11-438 (438) alignment 
Range on Protein: 33-440
Range on HMM: 11-438/438.0
TQEDIFPFLGGAGPYFSFPGDYGISRDLPEGCEMKQLQMLARHGERYPTYSKGATIMKTWYKLSNYTRQFNGSLSFLNDdYEFFIrDDDDLemeTTfans
.. .|...||.  ||||.||   || |.||||| ||.|.|.|||.|.||.||. .....| .| |.|  ..|.|||||| . ... . ..|   |.    
vdfnillhlgtlspyfsapgvglisldvpegcelkqvqvlfRHGaRtPtksklkkleplwellenattypsgplsflnd.wlgpc.gagqL...Tp....

dnvlnpyTGEMDAKRHAREFLAQYGYMfeNQTSF-PIFAASSERVHDTAQYFIDGL-GDQF----------NISLQTVSEAMSAGANTLsAGNACPGWDE
       .|  .|. . . . . ||..  |.  .  ... ...|....||.|. || ....          .| ..|..|...   |.|   . || .||
.......lGreqayelGkrlrkrYglL..npedvlyvrssdvdRtlqSAqaflaGlfppegtgelapilwqpipihtipesddfllnll.psdscpafde

DANDDIL-DKYDTTYLDDIAKRLNKENKGLNLTSKDANTLFAWCAYELNARGY-----SDVCDIFTEDELVRYSYGQDLVSFYQDGPGYDMIRSVGANLF
  ....  |..  ..|.||.|||.| ..||||| .|...|. .|||.. |.||     |. |..||..||  ..| .||. .|  |.|... . .|  |.
llkeflasdeflelllkdilkrlkkllpglnltpsdvldlydlcaydtlangyaglplspfcslftpeelevleyladlefyylygygnelaklaggpll

NATLKLLKQSETQ------------------DLKVWLSFTHDTDILNYLTTAGIIDDKNNLTAEYV--PFMGNTFHKSWYVPQGARVYTEKFQCS--NDT
|..|. |..  .                   |||..|.|.|||.|...|.. |. ||.  |.  ..  ......|. |..|| ......|...|.  ...
neilarledaingkstnlnltldsngvtfPldlklylyfaHdttiaallsaLglfddtwplpglpldkialnrlfrsseivPyasnlvfElyecpsdgey

YVRYVINDAVVPIETCSTGPGFSCEINDFYDYAEKRVAGtDFLKVCNV
|||...|..|.|.. |..|||..|. .||... .|.. | || ..|..
yVrvlyngkvlplpgcgsgpgglCplddFkelvkkllpg.dfeelCgl
0046349 Phosphoglycerate mutase-like 60-455 1.7e-65 214.7 In-house 2-407 (409) alignment 
Range on Protein: 60-455
Range on HMM: 2-407/409.0
LPeGCEMKQLQMLARHGERYPTYSkgatimktwyklsnytrqfngsLSFLNDDYEFFIRddddlemetTFANSDNVLNPyTGEMDAKRHAREFLAQY--G
.| |||.||.|.|.|||.|.||..                      ||||... .. .          ..   .  | | .|  .| .. . . . |  .
vP.gceLkqvqvlfRHGaRtPtkk......................lsflpnwpginwt.........ngpcgagqLTp.lGreqayelGkrlrkrYvdl

YMFENQ-----TSFPIFAASSERVHDTAQYFIDGLGD--------------------QFNISLQTVSEAMSAGANTLSAGNACPGWDEDAN------DDI
 .. ..     . . ... ...|. ..||.|. || .                     ..|.....||. . ... |  . .|| .|.. .      ...
gLlpsnslynpdeiyvrssdvdRtlqSAqaflaGlfpplggeivpllrqdlldppfqpipidtvpiseddalddtllppdslcpaldkllkenlkslsev

LD-----------KYDT--TYLDDIAKRLNKENKGLNLT-SKDANT-LFAWCAYELNA-RGYSDVCDIFTEDELVRYSYGQDLVSFYQDGPGyDMIRSVG
|.           ..|.  ..|. .|.|||.|..|||||  .|.   |. ...||.   ..... ||.||..|| ...| .||  .|..|.| .. . .|
leflvdealldlelldetkdllkklaerlnselpglnltdpldvasllydtllyetahglplppwcdlftpeelkvlayladleyyylygsg.elaklag

ANLFNATLKLLKQSETQ--------DLKVWLSFTHDTDILNYLTTAGIiddknnltaeyvpfMGNTFHKSWYVPQGARVYTEKFQC--SNDTYVRYVIND
  |.|. |. |..  ..        |||..|.|.|||.|...|.. |.               ...|. |...| ......|...|  ....|||...|.
gpllneilarledaisgknpvtfpldlklylyfaHdttiaallsaLgl..............fdrlfrssdippyasnlvfElyecpsdgeyyVrvlyng

AVVPIETCSTGpgfsCEINDFYDYAEKRVAGT---DFLKVCNVSSVSNVTELTFYWDW
...|.  |..|    |. ..|... .||. |.   || |.|....  .. . ....|.
gplplpgcgeg....cplsefkellkkrlpgcgltdfdklCpledflrfvdkailsdl
0048439 Phosphoglycerate mutase-like 59-429 3.8e-64 210.4 In-house 2-390 (391) alignment 
Range on Protein: 59-429
Range on HMM: 2-390/391.0
DLPEGCEMKQLQMLARHGERYPTYSKGATIMKTWYKlsnytrqfngslsflnddyeffirddddlemetT--F-ANSDNVLNPYtGEMDAKRHAREFLAQ
|.|.||| ||.|.|.|||.|.||.| .  . ....|                                 .  .    .. | |. |  ..  . | . . 
dvpagcelkqvqvlfRHGaRtPtssypnkldpllnk.................................llpngpcglgeLTpl.GreqlyelGrrlrkr

Y--GYMFE-----NQTSFPIFAASSERVHDTAQYFIDGL--GDQFNISLQTVSEAMSAGANTLsAGNACPGWDEDANDDILDKYDTTYLDDIAKRLNKEN
|  . ..      |.. . ... ...|. ..||.|. ||  . .... |. |.| .. ..| | . | || .. ....|.|. .. .||..| .||....
YvdlgllpskytlnpsevyvrssdvdRtlqSAqaflaGlfpplgltvilvivvesedpllnpl.pintcplledlllldalsalprfylseilerlaevl

---KGLNLTSKDANTLFAWCAYELNARGY-----SDVCDIFTEDELVRYSYGQDLV-------------------------SFYQDGPGyDMIRSVGANL
   .||||| .|  .|| .||.|..|.|.     |..||.||  . . | | ..|                           .|. |.| .. . .|  |
nrvlglnltaedvlslfdlcaketaalgsllklssplcdlftlydtllyeyahglplpewltdellspellkqladlvnelyyyltgsg.eiaklaggpl

FNATLKLLKQSETQDLKVWLSFTHDTDILNYLTTAGIIDDKNNLTAEYvpfmgntfhkswyVPQGARVYTEKFQC--SNDTYVRYVINDA----------
.|..|. |...  .|.|..| |.|||.|.. |.. |. .|   |.| .             .| ......|...|  ....||| ..|..          
lneilddlvangpsdpklylyfaHdttiaallsaLglfndtlplpadl.............ppyasnlvfElyecpsdgeyyVrvlynggtldlprdltl

----------VVPIETCSTGPGFSCEINDFYDYAEKRV
          |.|.  |..|||..|...||... .||.
ldldefllrlvlplpgcgsgpgglCplddFvelvkkri
0053031 Phosphoglycerate mutase-like 65-438 1.9e-56 184.8 In-house 2-340 (342) alignment 
Range on Protein: 65-438
Range on HMM: 2-340/342.0
EMKQLQMLARHGERYPTYSKGATIMKTWYKlsnytrqfngslsflnddyeffirddddlemettfansD---NVLNpYTGEMDAKRHAREFLAQYGYMFE
|.||...|.|||.|.|...   .  ..|.                                       .   . |  ..|  .|. . | .   |.  . 
eLkqvivlvRHGaRtPlskgpldplnewfy......................................pcgageLT.plGreqayelGrrlrkrYlgllp

---NQTSFPIFAASSERVHDTAQYFIDGLGDQFN--IS--------LQTVSEAMSAGANTLSAGNACPGWDEDANDDILDKYDTTYLDDIAKRLNKENKG
   |.. . ... ...|. ..||.|. || .. .  |         .. ..|. | .|. |     || .|.  .... ...  ..|......|.| .||
stynpdevyvrssdvdRtlqSAqaflaGlfppegtpilnpllgwqpipihtepessdalllpnydpcpafdkllkealaseevkellerylellqklskg

LNLTSKD----ANTLFAWCAYELNA-RGYSDVCDIFTEDELVRYsYGQDLVSFYQDGPGYDMIRSVGANLFNATLKLLKQ--SETQDLKVWLSFTHDTDI
|.|| .|    ...|. ...|||   ..... |..|| .|| .. | .||  .|. |||..... .|  |.|. |. |..  |.. |||..| |.|||.|
lgltlsdlldlvsdlydlllyelahglplppwctlftleelkal.yaldllyyyglgpgnelaklaggpllneilarleekisgpldlklylyfahdtti

LNYLTTAGIIddknnltAEYVPfmgntfhkswyvPQGARVYTEKFQCSNDTYVRYVINDA------VVPIETCstgPGfSCEINDFYDYAEKRVAGtDFL
...|.. |.         .. |            | ......|........|||...|..      |.|.  |   .| .|....|... .|.. | || 
aallsaLglf.......ddqlP............pyasnlvfElyedpgeyyVrvlynggtlseplvlplpgc...dg.lcplsefkelvkkllpg.dfe

KVC
|.|
klC
0049226 Phosphoglycerate mutase-like 65-438 2.8e-55 180.9 In-house 2-340 (342) alignment 
Range on Protein: 65-438
Range on HMM: 2-340/342.0
EMKQLQMLARHGERYPTYSKGATIMKTWYklsnytrqfngslsflnddyeffirddddlemettFANSDNVLNpYTGEMDAKRHAREFLAQYGYMFENQ-
..||.|.|.|||.|.|...   .  . |.                                   . .... |  ..|  .|  ..| .   |.  . .  
kLkqvqvliRHGdRtPlakgpldflnewf...................................wgcglgeLT.plGreqayelGrrlrkrYlgllpsty

--TSFPIFAASSERVHDTAQYFIDGLGDQFNIS----------LQTVSEAMSAGANTLSAGNACPGWDEDANDDILDKYDTTYLDDIAKRLNKENK--GL
  . . ... ...|. ..||.|. || .. ...          .....|  | ... |   . || .|.  .. . ...   .|..|...|.|  |  ||
npdevyvrssdvdRtlqSaqaflaGlfppeltpilvplldwqpipiitepesndtllllpydscpnfdkllkellkseevqlfleeildllkklskllgl

NL-TSKDANT-LFAWCAYELNAR-GYSDVCDIFTEDELVRYsYGQDLVSFYQDGPGYDMIRSVGANLFNATLKLLKQSE--TQDLKVWLSFTHDTDILNY
|| |..|.   |. ...|||. . .... |..|| .||  . | .||  .|  |.|... | .|  |.|. |. |..    . |||..|.|.|||.|...
nlstlsdvadtlydlllyelahglplppwcslftleelkal.yaldllyyygigygeeiarlaggpllneilarleeaiegpsdlklylyfahdttiaal

LTTAGIIDdknnltaEYVPfmgntfhkswyvPQGARVYTEKFQCSNDTYVRYVINDAV------VPIETCstgPGFsCEINDFYDYAEKRVAGtDFLKVC
|.. |. |       ...|            | ......|...|....|||...|..|      .|.  |   .|. |....|... .|.. | || ..|
lsalglfd.......dqlP............pyasnlvfElyecdgeyyVrvlynggvlslpvtlplpgc...dgl.cpldefkelvkkflpg.dfeelC
His_Phos_2 Histidine phosphatase superfamily (branch 2) 65-399 5.9e-51 166.4 Pfam-A 1-347 (347) alignment 
Range on Protein: 65-399
Range on HMM: 1-347/347.0
EMKQLQMLARHGERYPTYSKGATIMKTWYKLSN-YTRQFNGSLSFLNDDYEffirddddleMETTFANSDNVLNPYtGEMDAKRHAREFLAQYGYMFENQ
|.|..... |||.|.|. ...... ... .    .. .... ..|...  .           . ..      |... |.. |. .....  .|. .. ..
eLkgvvvviRHGdRtPkqkfkksvtsekfisllklknvlekkghfpgtkrk..........eklqlilkwgglThs.GrkqaeelGeqlrqrYpgllrdh

---TSFPIFAASSERVHDTAQYFIDGLGDQF---------------NISLQTVSEAMSAGANTLSAGN-ACPGWDE------DANDDILDKYDTTYLDDI
     . |.. |..||...||.|. || ..                |.  .|..|. .. .. | .|. .|| ...      .  .. ..|..  . ...
ltyedvkirssserRvlaSAqafaaGllgpegelllsirkdllddsnaakdtmdevkkklkellregaescpafawppikvekrvvelvnklkkvmdenl

AKRLNKENKG-LNLTSKDANTLFAWCAYELNARGYSDVCDIFTE--DELVRYSYGQDLVSFYQD-GPGYDMIRSVGANLFNATLKLLKQSETQDL-----
||||..  .|  ||. |.  ... ....| . . .|........  ...  ... .||  .|.  |.|  . .  |  |.|. || ....  ..      
akrlsalctgednllfkerweklfreffeeekfdiskipelydtmkydalhnrqledleelyklygigdeeklkigllllnpllkkilsdleetqpsrha

KVWLSFTHDTDILNYLTTAGIIDDKNNLtaeyvpfmgntfhKSWYVPQGARVYTEKFQCSND-TYVRYVIN
|..| ||||..|.. |.. |. .. . .             .|...| ......| ...|.. .|||....
klrlyfthDshiytllnaLgleekiare.............aspelpyasqivfelyedsekkfyvrllfs
His_Phos_2 Histidine phosphatase superfamily (branch 2) 65-399 5.9e-51 166.4 In-house 1-347 (347) alignment 
Range on Protein: 65-399
Range on HMM: 1-347/347.0
EMKQLQMLARHGERYPTYSKGATIMKTWYKLSN-YTRQFNGSLSFLNDDYEffirddddleMETTFANSDNVLNPYtGEMDAKRHAREFLAQYGYMFENQ
|.|..... |||.|.|. ...... ... .    .. .... ..|...  .           . ..      |... |.. |. .....  .|. .. ..
eLkgvvvviRHGdRtPkqkfkksvtsekfisllklknvlekkghfpgtkrk..........eklqlilkwgglThs.GrkqaeelGeqlrqrYpgllrdh

---TSFPIFAASSERVHDTAQYFIDGLGDQF---------------NISLQTVSEAMSAGANTLSAGN-ACPGWDE------DANDDILDKYDTTYLDDI
     . |.. |..||...||.|. || ..                |.  .|..|. .. .. | .|. .|| ...      .  .. ..|..  . ...
ltyedvkirssserRvlaSAqafaaGllgpegelllsirkdllddsnaakdtmdevkkklkellregaescpafawppikvekrvvelvnklkkvmdenl

AKRLNKENKG-LNLTSKDANTLFAWCAYELNARGYSDVCDIFTE--DELVRYSYGQDLVSFYQD-GPGYDMIRSVGANLFNATLKLLKQSETQDL-----
||||..  .|  ||. |.  ... ....| . . .|........  ...  ... .||  .|.  |.|  . .  |  |.|. || ....  ..      
akrlsalctgednllfkerweklfreffeeekfdiskipelydtmkydalhnrqledleelyklygigdeeklkigllllnpllkkilsdleetqpsrha

KVWLSFTHDTDILNYLTTAGIIDDKNNLtaeyvpfmgntfhKSWYVPQGARVYTEKFQCSND-TYVRYVIN
|..| ||||..|.. |.. |. .. . .             .|...| ......| ...|.. .|||....
klrlyfthDshiytllnaLgleekiare.............aspelpyasqivfelyedsekkfyvrllfs