Gene DIA3 in Saccharomyces cerevisiae

Synonym: YDL024C, DIA3

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP2
Subfamily MINPP1
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP011_AA protein Get Run
ScerP011_AA_32-461 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_MINPP1_pd Subfamily MINPP1 38-444 4.7e-139 455.8 In-house 2-419 (420) alignment 
Range on Protein: 38-444
Range on HMM: 2-419/420.0
LFPFLGGSAPYFSFPANYGIPTDIPEGCRLTQVQMIGRHGERYPTRSEAKDIFEVWYKISNYTGKYEGSLSFLNNGYEffipdeSLLEMETTLQNSIDVL
|..|||...||.|..|||.| .. .|||.|...|.|.|||.|||..|..|.| | ..||.||.....|.||.||. .|      | ||.||.|..|... 
lvkflgsktpyysvkanydikkeaeegCklvklqiiaRHGtRypskskikkiqetlekiknyseqldgklsilnedle......snleyetelekslvaq

NPYTGEMNAKRHAREFLAKYGkLMENCTNFPIFTTNSKRIYDTAQYFAEAL-------GDGFNISLQTLSENSSsgANTLAAKSSCPNWNSNANNDILMS
.....|..|||.||.|.| ..  ..|...| ...|..||....||.|||.|       || |||.||..||..|  ...| . .||...........|..
gqeeleelakrlarrfpalfe.evynpdsfsfastakkRtvksaqaFaeGLsetgevlgdefnivlqeiseqes..dklLrffdsCkkyknkvkknelnl

YSR----------DYLENISDRLNDENKGLNLSRKDAAALFSWCAFELNAKGYSNI-CDIFSAAELIHYSYETDLTSFYQNGPGYKLIKSIGANLFNATV
...          ..||.|..|||.|.|.|.|..||.  .|..||.||..||.||. |..|. .||....| .||...|..|.||....||...|.|..|
keeeefleskelqkaleeiakrlneekklleltekdiedmfeiCayelaikgisnvWcslfekdelleleYledLknyykegyGyeinysiscpLlndiv

KLIRQSAHLDQKVW-LSFTHDTDILNYLTTAGLIDDTRNLTT-NHVPFRDHSYHRSWYIPQGARVYTEKFQCSNDSY-VRYVVNDAVVPIESCSSGPGFs
||...| . .||.. |.|.|....|..|...||..|...||. |...........|.. |..|........||.|.| |....|..||..| ||.|..| 
kllksseeqkqkssslrFaHaetllpllsllGlykDeekLtannyhklsnrkfrssvivpyaanlafvlydCskdqykvlvllnekvvkletcsegeif.

CEEGTFYEYAKDRLRGVSFYEDCDVSKV
||  .|.|..|........ . |.||||
CelqdfkeiykkivdncdleklCevskv
0048946 Phosphoglycerate mutase-like 34-461 2.6e-86 283.2 In-house 9-430 (447) alignment 
Range on Protein: 34-461
Range on HMM: 9-430/447.0
SQKSLFPFLGGSAPYFSFPaNYGIPTDIPEGCRLTQVQMIGRHGERYPTRSEAKDIFEVWYKISNYTGK-YEGSLSFLNNgYEFFIPDESLLEmettlqN
........||...||||.| .||||...||||.|.|||.. |||.|.|| .  |..  ..... |...  . |.|||||. .. .. .| | .       
dgfnillhlgtlspyfsvp.gygipepvpegcelkqvqvlfRHGaRtPtkkylkgleplldllknanvlelggdlsflnd.wkyqlkneplwp......c

SIDVLNPyTGEMNAKRHAREFLAKYGKLMENCTNFPIFTTNSKRIYDTAQYFAEALGDGF---NISLQTLSENSSSGANTLAAksSCPNWNSNANNDILm
  . | | .|   .  . . .  .|..|. | ... ...... | ...||.|. .| .     .. . .  .  ||. |.|.   |||....  .. .  
glgqLTp.lGreqlyelGkrlrkrYlgllpnpseiyvrssdvdRtlqSaqaflaGlfppepplgyqpipihtvpssndnlllp..sCpafkellkkela.

SYSRDYLENISDRLNDENKGLNLSRKDAAALFSWCAFELNAKGYSNICDIFSAAELIHYSYETDLTSFYQNGPGYKLIKSIGANLFNATVKLIRQSAHLD
.. ...|... .||.. ..||||. .|.  |. ....|... |.|. |..|.  ||  . |  ||  .| .|.|..| . .|  |.|. .. ... .  |
eelkellkellerlkkllgglnltlsdvydlydlllyetaihglsplcslftpeelevleyladlefyyeygygdelarlaggpllneilarledaisgd

QKVWLSFTHDTDILNYLTTAGLIDDTRNLTTNHVPFrDHSYHRSWYIPQGARVYTEKFQC------SNDSYVRYVVNDAVVPIESCSSGPGFSCEEGTFY
.|..|.|.|||.|.. |.. || ||.  |.....|| ..... |...| ......|...|      ... |||...|....|.. |.||||..|.  .| 
sklylyfaHdttiaallsaLglfddelplpadnlpf.nrlfrsseivPyasnlvfElyecpsslpsdgeyyVrvlyngeplplpgCgsgpgglCplddFk

EYAKDRLRgvSFYEDCDVSKvSKEKELTFYWDWNTTRY
|. |..|   .... |.... |  ..|....|.... .
ellkkflp..dweklCgltl.svlallsvlidvllltl
0047369 Phosphoglycerate mutase-like 33-440 1.1e-78 258.3 In-house 10-437 (438) alignment 
Range on Protein: 33-440
Range on HMM: 10-437/438.0
GSQKSLFPFLGGSAPYFSFPANYGIPTDIPEGCRLTQVQMIGRHGERYPTRSEAKDIFEVWYKISNYTGKYEGSLSFLNNgYEFFIPDESLLEmettlqn
 .. .....||. .||||.|    |..|.||||.|.|||.. |||.|.|| |  |..  .| .. |.|. . |.|||||. . .... . | .       
svdfnillhlgtlspyfsapgvglisldvpegcelkqvqvlfRHGaRtPtksklkkleplwellenattypsgplsflnd.wlgpcgagqLTp.......

sidvlnpyTGEMNAKRHAREFLAKYGKLmeNCTNF-PIFTTNSKRIYDTAQYFAEALGDGF-----------NISLQTLSENSSSGANTLaAKSSCPNWN
        .|   |. . . . ..|| |  |  ..  ...... | ...||.|.  | ..            .| ..| .|....  |.|   .|||...
........lGreqayelGkrlrkrYglL..npedvlyvrssdvdRtlqSAqaflaGlfppegtgelapilwqpipihtipesddfllnll.psdscpafd

SNANNDILMSYSRDY-LENISDRLNDENKGLNLSRKDAAALFSWCAFELNAKGY-----SNICDIFSAAELIHYSYETDLTSFYQNGPGYKLIKSIGANL
   .... ..   .  |..|..||.. ..||||. .|. .|. .||... |.||     |. |..|.  ||  ..|  ||  .| .|.|..| | .|  |
ellkeflasdeflelllkdilkrlkkllpglnltpsdvldlydlcaydtlangyaglplspfcslftpeelevleyladlefyylygygnelaklaggpl

FNATVKLIRQSAHL------------------DQKVWLSFTHDTDILNYLTTAGLIDDTRN---LTTNHVPfRDHSYHRSWYIPQGARVYTEKFQCS--N
.|.... ... .                    |.|..|.|.|||.|...|.. || |||     |...... ... .. |.. | ......|...|.  .
lneilarledaingkstnlnltldsngvtfPldlklylyfaHdttiaallsaLglfddtwplpglpldkia.lnrlfrsseivPyasnlvfElyecpsdg

DSYVRYVVNDAVVPIESCSSGPGFSCEEGTFYEYAKDRLRGvSFYEDCD
. |||...|..|.|.. |.||||..|.  .|.|. |..| | .|.| |.
eyyVrvlyngkvlplpgcgsgpgglCplddFkelvkkllpg.dfeelCg
0049059 Phosphoglycerate mutase-like 34-440 4.2e-78 256.2 In-house 10-435 (435) alignment 
Range on Protein: 34-440
Range on HMM: 10-435/435.0
SQKSLFPFLGGSAPYFSFPANYGIPTDIPEGCRLTQVQMIGRHGERYPTRSEAKDIFEVWYKISNYTGKYEGSLSFLNNgYEFFIPdesllemettlqns
.. ... .||. .||||.|  .||. |.||||.|.|||.. |||.|.|| .  |..  .| |. ... .. |.|||||. ......              
dgfnillllgtlspyfsapgvfgisldvpegcelkqvqvlfRHGaRtPtsklikklealwekllslltypngplsflnd.wnyplg..............

IDVLNPyTGEMNAKRHAREFLAKYGKLmENCTNFPIFTTNSKRIYDTAQYFAEALGDGF----------NISLQTLSENSSSGANTLaAKSSCPNWNSNA
 . | | .|   |..... . ..||.|  | ... ...... | ...||.|...| ..           |. ...  |  .|. .||   .|||...   
ageLTp.lGreqayelGkrlrkrYgfL.ynpdevyvrssdvdRtlqSaqaflaGlfppeilgsqllnplnvyqpvpietvdsdndtl.pydscpafdell

NNDILMSYSRDY-LENISDRLNDENKGLNLSRKDAAALFSWCAFELNAKGY-----SNICDIFSAAELIHYSYETDLTSFYQNGPGYKLIKSIGANLFNA
.... ..   .  ||.|...|.. ..||.|. .|  .|...|.... . ||     .. |..|.  ||  ..|  ||  .|..|.|... | .|  |.|.
kellasdeflelflerilkllqellpglgltpsdvldlydlckydtlllgyahglplpfcslfteeelevleyladlefyylygygdeiaklaggpllne

TVKLIRQSA------------------HLDQKVWLSFTHDTDILNYLTTAGLIDDTRNLTTNHVPFR--DHSYHRSWYIPQGARVYTEKFQCSN--DSYV
 .. ... .                  .||.|..|.|.|||.|.. |.. || ||.  |.....||.  |.... |.. | ......|...|..  . ||
ilarledaingdstnlnltldsnpatfpldlklylyfaHdttiapllsaLglfddqlplpadntpfpeldrlfrtseivPyasnlvfElyecpdgneyyV

RYVVNDAVVPIESCSSGPGFSCEEGTFYEYAKDRLRGVSFYEdCD
|...|..|.|.. |.||||..|.  .| |. |..| |  | | |.
rvlyngkvlplpgcgsgpgglCplddFkelvkkflpgddfde.Cg
0048439 Phosphoglycerate mutase-like 60-429 1.4e-62 205.3 In-house 2-389 (391) alignment 
Range on Protein: 60-429
Range on HMM: 2-389/391.0
DIPEGCRLTQVQMIGRHGERYPTRSEAKDIFEVWYKisnytgkyegslsflnngyeffipdesllemettlqN------SIDVLNPYtGEMNAKRHAREF
|.|.||.|.|||.. |||.|.|| |  . . ....|                                    .        . | |. |   .  . | .
dvpagcelkqvqvlfRHGaRtPtssypnkldpllnk....................................llpngpcglgeLTpl.GreqlyelGrrl

LAKY--GKLME-----NCTNFPIFTTNSKRIYDTAQYFAEAL--GDGFNISLQTLSENSSSGANTLaAKSSCPNWNSNANNDILMSYSRDYLENISDRLN
 ..|  ..|.      | ... ...... | ...||.|...|  . |... |.  .|. ....| | .  .||.... .. |.| .. | || .| .||.
rkrYvdlgllpskytlnpsevyvrssdvdRtlqSAqaflaGlfpplgltvilvivvesedpllnpl.pintcplledlllldalsalprfylseilerla

DEN---KGLNLSRKDAAALFSWCAFELNAKGY-----SNICDIFSAAELIHYSYETDLT-------------------------SFYQNGPGyKLIKSIG
...   .||||. .| ..||..||.|..|.|.     |..||.|.  . . | |  .|.                          .|..|.| .. | .|
evlnrvlglnltaedvlslfdlcaketaalgsllklssplcdlftlydtllyeyahglplpewltdellspellkqladlvnelyyyltgsg.eiaklag

ANLFNATVKLIRQSAHLDQKVWLSFTHDTDILNYLTTAGLIDDTRNLTTNHvpfrdhsyhrswyIPQGARVYTEKFQC--SNDSYVRYVVNDA-------
  |.|.... ....  .|.|..| |.|||.|.. |.. || .||  |.. .             .| ......|...|  ... ||| ..|..       
gpllneilddlvangpsdpklylyfaHdttiaallsaLglfndtlplpadl.............ppyasnlvfElyecpsdgeyyVrvlynggtldlprd

-------------VVPIESCSSGPGFSCEEGTFYEYAKDR
             |.|.  |.||||..|.  .|.|. |.|
ltlldldefllrlvlplpgcgsgpgglCplddFvelvkkr
0046349 Phosphoglycerate mutase-like 61-446 1.4e-61 201.8 In-house 2-397 (409) alignment 
Range on Protein: 61-446
Range on HMM: 2-397/409.0
IPeGCRLTQVQMIGRHGERYPTRSeakdifevwykisnytgkyegsLSFLNNGYEFFIPdesllemetTLQNSIDVLNPyTGEMNAKRHAREFLAKY--G
.| ||.|.|||.. |||.|.|| .                      ||||.|  .. ..         . .  .. | | .|   | .. . . ..|  .
vP.gceLkqvqvlfRHGaRtPtkk......................lsflpnwpginwt.........ngpcgagqLTp.lGreqayelGkrlrkrYvdl

KLMENC-----TNFPIFTTNSKRIYDTAQYFAEALGD--------------------GFNISLQTLSENSSSGANTLAAKSSCPNWNSNAN------NDI
.|. .      ... ...... | ...||.|...| .                    ...|.....||  . ... |. .|.||..... .      ...
gLlpsnslynpdeiyvrssdvdRtlqSAqaflaGlfpplggeivpllrqdlldppfqpipidtvpiseddalddtllppdslcpaldkllkenlkslsev

LM-------------SYSRDYLENISDRLNDENKGLNLS-RKDAAA-LFSWCAFELNA-KGYSNICDIFSAAELIHYSYETDLTSFYQNGPGyKLIKSIG
|              .   |.|. ...||| |..||||.  .|.|. |. ....|.   ..... ||.|.  || ...| .||  .|..|.| .| | .|
leflvdealldlelldetkdllkklaerlnselpglnltdpldvasllydtllyetahglplppwcdlftpeelkvlayladleyyylygsg.elaklag

ANLFNATVKLIRQSAH--------LDQKVWLSFTHDTDILNYLTTAGLiddtrnlttnhvpfRDHSYHRSWYIPQGARVYTEKFQC--SNDSYVRYVVND
  |.|. .. ... .         ||.|..|.|.|||.|...|.. ||               |.... |...| ......|...|  ... |||...|.
gpllneilarledaisgknpvtfpldlklylyfaHdttiaallsaLgl..............fdrlfrssdippyasnlvfElyecpsdgeyyVrvlyng

AVVPIESCSSGpgfsCEEGTFYEYAKDRLRGV---SFYEDCDVSKVSK
...|. .|..|    |.  .|.|. |.|| |.   .| . |....  .
gplplpgcgeg....cplsefkellkkrlpgcgltdfdklCpledflr
His_Phos_2 Histidine phosphatase superfamily (branch 2) 67-400 1.8e-56 184.5 Pfam-A 2-347 (347) alignment 
Range on Protein: 67-400
Range on HMM: 2-347/347.0
LTQVQMIGRHGERYPTRSEAKDIFEVWYKISN-YTGKYEGSLSFLNNGYEffipdeslleMETTLQNSIDVLNPYtGEMNAKRHAREFLAKYGKLMENC-
|..|... |||.|.|. . .|.. . . ..   ... .|. ..|...  .           . .|.   . |... |...|. .....  .|..|. .  
LkgvvvviRHGdRtPkqkfkksvtsekfisllklknvlekkghfpgtkrk..........eklqlilkwgglThs.GrkqaeelGeqlrqrYpgllrdhl

--TNFPIFTTNSKRIYDTAQYFAEALG--DG-------------FNISLQTLSENSSSGAN-TLAAKSSCPNWNS------NANNDILMSYSRDYLENIS
   .. |......|....||.||..|   .|              |.  .|..| ... .. ... ..|||....      .   . . ...... ||..
tyedvkirssserRvlaSAqafaaGllgpegelllsirkdllddsnaakdtmdevkkklkellregaescpafawppikvekrvvelvnklkkvmdenla

DRLNDENKG-LNLSRKDAAALFSWCAFELNAKGYSNICDIFSA--AELIHYSYETDLTSFYQN-GPGYKLIKSIGANLFNATVKLIRQSAHLDQ-----K
.||..  .|  ||. |.  .......|| . . .|.|.....    ...|... .||. .|.. |.| .. . ||  |.|. .| |..... .|     |
krlsalctgednllfkerweklfreffeeekfdiskipelydtmkydalhnrqledleelyklygigdeeklkigllllnpllkkilsdleetqpsrhak

VWLSFTHDTDILNYLTTAGLIDDTRNLttnhvpfrdhsyhRSWYIPQGARVYTEKFQCSND-SYVRYVVN
..| ||||..|.. |.. || ...  .             .|...| ......| ...|..  |||....
lrlyfthDshiytllnaLgleekiare.............aspelpyasqivfelyedsekkfyvrllfs
His_Phos_2 Histidine phosphatase superfamily (branch 2) 67-400 1.8e-56 184.5 In-house 2-347 (347) alignment 
Range on Protein: 67-400
Range on HMM: 2-347/347.0
LTQVQMIGRHGERYPTRSEAKDIFEVWYKISN-YTGKYEGSLSFLNNGYEffipdeslleMETTLQNSIDVLNPYtGEMNAKRHAREFLAKYGKLMENC-
|..|... |||.|.|. . .|.. . . ..   ... .|. ..|...  .           . .|.   . |... |...|. .....  .|..|. .  
LkgvvvviRHGdRtPkqkfkksvtsekfisllklknvlekkghfpgtkrk..........eklqlilkwgglThs.GrkqaeelGeqlrqrYpgllrdhl

--TNFPIFTTNSKRIYDTAQYFAEALG--DG-------------FNISLQTLSENSSSGAN-TLAAKSSCPNWNS------NANNDILMSYSRDYLENIS
   .. |......|....||.||..|   .|              |.  .|..| ... .. ... ..|||....      .   . . ...... ||..
tyedvkirssserRvlaSAqafaaGllgpegelllsirkdllddsnaakdtmdevkkklkellregaescpafawppikvekrvvelvnklkkvmdenla

DRLNDENKG-LNLSRKDAAALFSWCAFELNAKGYSNICDIFSA--AELIHYSYETDLTSFYQN-GPGYKLIKSIGANLFNATVKLIRQSAHLDQ-----K
.||..  .|  ||. |.  .......|| . . .|.|.....    ...|... .||. .|.. |.| .. . ||  |.|. .| |..... .|     |
krlsalctgednllfkerweklfreffeeekfdiskipelydtmkydalhnrqledleelyklygigdeeklkigllllnpllkkilsdleetqpsrhak

VWLSFTHDTDILNYLTTAGLIDDTRNLttnhvpfrdhsyhRSWYIPQGARVYTEKFQCSND-SYVRYVVN
..| ||||..|.. |.. || ...  .             .|...| ......| ...|..  |||....
lrlyfthDshiytllnaLgleekiare.............aspelpyasqivfelyedsekkfyvrllfs
0049226 Phosphoglycerate mutase-like 66-439 7.3e-55 179.5 In-house 2-340 (342) alignment 
Range on Protein: 66-439
Range on HMM: 2-340/342.0
RLTQVQMIGRHGERYPTRSEAKDIFEVWYkisnytgkyegslsflnngyeffipdesllemettLQNSIDVLNpYTGEMNAKRHAREFLAKYGKLMENC-
.|.|||.. |||.|.|. .  .| .  |.                                    ..... |  ..|   |  ..| .   |..|. .. 
kLkqvqvliRHGdRtPlakgpldflnewf...................................wgcglgeLT.plGreqayelGrrlrkrYlgllpsty

--TNFPIFTTNSKRIYDTAQYFAEALGDGFNIS----------LQTLSENSSSGANTLAAKSSCPNWNSNANNDILMSYSRDYLENISDRLNDENK--GL
  ... ...... | ...||.|. .| .. ...          ... .|..|.... |  ..||||...  .. . ...  ..||.| |.|..  |  ||
npdevyvrssdvdRtlqSaqaflaGlfppeltpilvplldwqpipiitepesndtllllpydscpnfdkllkellkseevqlfleeildllkklskllgl

NL-SRKDAAA-LFSWCAFELNAK-GYSNICDIFSAAELIHYsYETDLTSFYQNGPGYKLIKSIGANLFNATVKLIRQSA--HLDQKVWLSFTHDTDILNY
|| . .|.|  |. ....||. . .... |..|.  ||. . |. ||  .| .|.|... . .|  |.|. .. ...    ..|.|..|.|.|||.|...
nlstlsdvadtlydlllyelahglplppwcslftleelkal.yaldllyyygigygeeiarlaggpllneilarleeaiegpsdlklylyfahdttiaal

LTTAGLIDdtrnlttNHVPfrdhsyhrswyiPQGARVYTEKFQCSNDSYVRYVVNDAV------VPIESCssgPGFsCEEGTFYEYAKDRLRGvSFYEDC
|.. || |        ..|            | ......|...|... |||...|..|      .|.  |   .|. |.  .|.|. |..| | .|.| |
lsalglfd.......dqlP............pyasnlvfElyecdgeyyVrvlynggvlslpvtlplpgc...dgl.cpldefkelvkkflpg.dfeelC
0053031 Phosphoglycerate mutase-like 66-439 1.5e-54 178.6 In-house 2-340 (342) alignment 
Range on Protein: 66-439
Range on HMM: 2-340/342.0
RLTQVQMIGRHGERYPtrseakdifevwykisnytgKYEGSLSFLNNGYEffipdesllemettlQNSIDVLNpYTGEMNAKRHAREFLAKYGKLMENCT
.|.||... |||.|.|                    .. | |..||. .                . . . |  ..|   |. . | .   |..|. .. 
eLkqvivlvRHGaRtP....................lskgpldplnewfy...............pcgageLT.plGreqayelGrrlrkrYlgllpsty

N---FPIFTTNSKRIYDTAQYFAEAL--GDGFNIS--------LQTLSENSSSGANTLAAKSSCPNWNSNANNDILMSYSRDYLENISDRLNDENKGLNL
|   . ...... | ...||.|...|  ..|..|         ..  .|. ||.|. |  ...||....  .... ...  ..||.....|.  .|||.|
npdevyvrssdvdRtlqSAqaflaGlfppegtpilnpllgwqpipihtepessdalllpnydpcpafdkllkealaseevkellerylellqklskglgl

SRKD----AAALFSWCAFELNA-KGYSNICDIFSAAELIHYsYETDLTSFYQNGPGYKLIKSIGANLFNATVKLIRQS--AHLDQKVWLSFTHDTDILNY
. .|    .  |......||    .... |..|   ||... |. ||  .|..|||..|.| .|  |.|. .. ...    .||.|..| |.|||.|...
tlsdlldlvsdlydlllyelahglplppwctlftleelkal.yaldllyyyglgpgnelaklaggpllneilarleekisgpldlklylyfahdttiaal

LTTAGLIddtrnltTNHVPfrdhsyhrswyiPQGARVYTEKFQCSNDSYVRYVVNDA------VVPIESCssgPGfSCEEGTFYEYAKDRLRGvSFYEDC
|.. ||        ... |            | ......|....... |||...|..      |.|.  |   .| .|.  .|.|. |..| | .|.. |
lsaLglf.......ddqlP............pyasnlvfElyedpgeyyVrvlynggtlseplvlplpgc...dg.lcplsefkelvkkllpg.dfeklC