Gene PTP1 in Saccharomyces cerevisiae

Synonym: YDL230W, PTP1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily Fungi-PTP1
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP015_AA protein Get Run
ScerP015_AA_33-329 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 22-333 1.1e-131 433.8 In-house 6-348 (350) alignment
Range on Protein: 22-333
Range on HMM: 6-348/350.0
IQNQEDGRLREATNGTVNSRWSLGVSIE-PRND----------ARNRYVNIMPYERNRVHLK-----------TLSGNDYINASYVKVNVPGQSIEPGY-
.| ..  .|  . |.||.||.||....| |.||          |.|||.||.|||..||.||           .||.||||||.|.|.......|.|.. 
vqkrsklkliitknstvksrlsLesdsespsnDvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfk

YIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQYWPRGGVDD-TVRIASKWESPGGANDMTQFPSDLKIEFV------NVHKVKDYY
|||||.|...|.|.|......|   ...||...|..||.|.||||.||..|..|| ||..|||||...|.||......|.|.|..      .....||..
YiatqaPlpstvddfykvilln...kvkvilsltsdvelnlekcyrYWqegsydditvklaskwenimgindsslysadvkkeasdndnisddndlkdnn

TVTDIKLTPTDPLVgpvktVHHFYFDLWKDM---NKPEEVVPIME--------LCAHSHSLNSRGNPIIVHCSAGVGRTGTFIALDHLMHDTLDFKNITE
..|.|.|...||.|     |.......|||.   ..||......|        |.|.||. |.|..||.||||||||||||...||.|..|.....|.|.
sltaitlaasdPyv.....vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltk

RSRHSDRATEeyTRDLIEQIVLQLRSQRMKMVQTKDQFLFIYHAAKYLNSLSV
.||..|.|..  |||||..||..||.||..|||..|||.|||.|......|. 
esrkldvaak..trDlisiivnelrkqrismvqnldqfifiYeallfyfaLrk

DSPc_SM00195 40-326 9.1e-72 236.9 In-house 16-259 (263) alignment
Range on Protein: 40-326
Range on HMM: 16-259/263.0
SrwSLGVSIEPRNDARNRYVNIMPYERNRVHLKTL---SGNDYINASYVKVNvpgqsIEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVE
.  .   .....| ..||| ||.||...||.||.    .|.|||||.|.|..      ..  |||||||. .|...||.|....   .  .|||.|  .|
k..etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.....nkkkkyIatQgPlpstvedFWrmvwee...kvkiivmlteeee

YNREKCYQYWPRGGvddtvriaskwespggaNDMTQFPsDLKIEFVNVHKVKDYYTVTDIKLTPTDPlvGPVKTVHHFYFDLWKDMNKPEEV---VPIME
 ..|||..|||.                   .. ..|  ......|.|.|.|| .......|| ...     ..|... .  |.| . |..    . ...
ngkekcdrywpees.................ggketfg.kisvklvevekkkdeiilrtleltkegk..eetrkvtqyqyknWpdhgvpdstksvlellr

LCAHSHSLNsrGNPIIVHCSAGVGRTGTFIALDHLMHDTLDFKNitersrhsdrateeytrDLIEQIVLQLRSQRMKMVQTKDQFLFIYHAAK
 . .|.| .   .||.|||||||||||||...| ...   . |.                 . |..|| .||.||..||||..|.||||.|. 
avkksksts..sgpivVhCsaGvgRtgtfvtidiilskleeekk.................vdifeivkelRkqRpgmvqtleqYlfiyeail

PTPc_SM00194 40-326 9.1e-72 236.9 In-house 16-259 (263) alignment
Range on Protein: 40-326
Range on HMM: 16-259/263.0
SrwSLGVSIEPRNDARNRYVNIMPYERNRVHLKTL---SGNDYINASYVKVNvpgqsIEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVE
.  .   .....| ..||| ||.||...||.||.    .|.|||||.|.|..      ..  |||||||. .|...||.|....   .  .|||.|  .|
k..etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.....nkkkkyIatQgPlpstvedFWrmvwee...kvkiivmlteeee

YNREKCYQYWPRGGvddtvriaskwespggaNDMTQFPsDLKIEFVNVHKVKDYYTVTDIKLTPTDPlvGPVKTVHHFYFDLWKDMNKPEEV---VPIME
 ..|||..|||.                   .. ..|  ......|.|.|.|| .......|| ...     ..|... .  |.| . |..    . ...
ngkekcdrywpees.................ggketfg.kisvklvevekkkdeiilrtleltkegk..eetrkvtqyqyknWpdhgvpdstksvlellr

LCAHSHSLNsrGNPIIVHCSAGVGRTGTFIALDHLMHDTLDFKNitersrhsdrateeytrDLIEQIVLQLRSQRMKMVQTKDQFLFIYHAAK
 . .|.| .   .||.|||||||||||||...| ...   . |.                 . |..|| .||.||..||||..|.||||.|. 
avkksksts..sgpivVhCsaGvgRtgtfvtidiilskleeekk.................vdifeivkelRkqRpgmvqtleqYlfiyeail

0046845 (Phosphotyrosine protein) phosphatases II 37-328 6.3e-70 231.1 In-house 13-273 (284) alignment
Range on Protein: 37-328
Range on HMM: 13-273/284.0
TVNSRWSLGVSIEPRNDARNRYVNIMPYERNRVHLKTLSG----NDYINASYVKVNVPGQSIEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVT
||.  .|| |.. | |  .|||..|.||...||.||.|.|    .||||||||..   . .. .  .||||||. .|.. ||.|....   .  ||||.|
tvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq...nvrvIVmlt

PLVEYNREKCYQYWPRGgvDDTVRIaskwespggandmtqfpSDLKIEFVNVHKvKDYYTVTDIKLTPTdPLVGPVKTVHHFYFDLWKDMNKPEEVVPIM
.|||..||||.||||    ......                  |.......... ||.|||. ..||..  . |...||.||..  | |.. |... ...
elvengrekcaqYwple..gevlty.................gdftvtllseev.kddytvrtleltnl.gytgesrtvthfhytswpdhgvppspedll

ELCAHSHSLNSR---GNPIIVHCSAGVGRTGTFIALDHLMHDTLDFK---NITersrhsdrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHAAK
|..   ..|...   |.||.|||||||||||||||||.|..     .   ...                 ....| .||.||. |||| .|..|.|.|. 
eflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvd.................vleavkrlreqRpgmvqtleqyrfvyeall

YL
..
ey

0050432 (Phosphotyrosine protein) phosphatases II 45-328 1.1e-68 227.2 In-house 61-298 (308) alignment
Range on Protein: 45-328
Range on HMM: 61-298/308.0
GVSIEPRNDARNRYVNIMPYERNRVHLkTlSGNDYINASYVKVNVpgqSIEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQ
 |.  |.|  .|||..|.||...||.|   .|.||||||||.. .   |. |  .||||||. .|.. ||.|....   .  ||||.| |||..||||.|
svallpenkdkNrykdilpydhsRVkl.d.egsdYInAsyvdgys...sklprkfIatqgPlpntvedFwrmvweq...nvrvIvmLtklvengrekcaq

YWPRGGVDDTVRIaskwespggandmtqfpSDLKIEFVNVHKvKDYYTVTDIKLTPTDPLvgPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLNsR
|||    ......                  ........... .|.|||. ..||...    ...||.||..  |.|.. |... ...... . .. . .
Ywplelgggsley.................gkftvtllseev.lddytvrtleltnlgdg..esrtvthfhytnWpdhgvPpspeilldflelvrksl.p

GNPIIVHCSAGVGRTGTFIALDHLMHDTLDFKNITersrhsdrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHAAKYL
|.||.|||||||||||||||||.|..     ....                 ....| .||.||. ||||..|.||.|.|. ..
ggpivVHCsaGvGRtGtfialdllleqlekeggvd.................vfeavkklReqRpgmvqtpeqylflyralley

0051299 (Phosphotyrosine protein) phosphatases II 43-327 9.3e-67 220.8 In-house 40-284 (288) alignment
Range on Protein: 43-327
Range on HMM: 40-284/288.0
SLGVSIEPRNDARNRYVNIMPYERNRVHLKTLSG---NDYINASYVKVnvpgqSIEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNR
.| ... | |  .|||..|.||...||.|..|.|   .|||||||...        .  .||||||. .|.. ||.|....   .  ||||.|.|||..|
tlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidg.....ynlkrkfIatqgPlpntvedFWrmvweq...nvrvIvmltklvelgr

EKCYQYWPRggvDDTVRIaskwespggandmtqfpSDLKIEFVNVHKvKDYYTVTDIKLTPTDP--LVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAH
|||.||||    .... .                  |.......... .|.|||. ...|..|     | ..||.||..  | |.. |. . ...... .
ekcaqYwpl...ggslty.................gditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrl

SHSL-NSRGNPIIVHCSAGVGRTGTFIALDHLMHDTLDFKNITersrhsdrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHAAKY
 ..  .|.|.|..|||||||||||||||||.|..  .  . ..                 ....| .||.||. |||| .|..|.|.|. .
vrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvd.................vleavkrlreqRpgmvqtpeqyrfvyealle

0040438 (Phosphotyrosine protein) phosphatases II 42-328 2.8e-64 212.7 In-house 33-275 (317) alignment
Range on Protein: 42-328
Range on HMM: 33-275/317.0
WSLGVSIEPRNDARNRYVNIMPYERNRVHLKTLSG---NDYINASYVkvNVPGQSIEpgyYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYN
..  |.. | |  .|||..|.||...||.|. |.|   .||||||||  ..| .. .   .||||||. .|.. ||.|....   .  ||||.|.|.|..
dtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyv..dgpnlkrk...fIatqgPlpntvedFwrmvweq...gvtvivmLteleelg

REKCYQYWPRggvDDTVRIAskwespggandmtqfpsDLKIEFVNVHKvKDYYTVTDIKLTPTdpLVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHS
||||.||||    ..|. .                  |.......... ....|.. ......    ... ||.||..  | |.. |.   .. ...   
rekcaqYwpl...getltyg.................dftvtllseee.lagitlrtlevedl..gdsesrtvthfhytgWpdhgvppspdllldfleav

HSLNSR-GNPIIVHCSAGVGRTGTFIALDHLMHDTLDFKNITersrhsdrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHAAKYL
.. ... |.|..|||||||||||||||.. ...     ....                 .|..| .||.||...||| .|. |.| |. ..
realedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvd.................veeavkelreqRpgavqtpeqyrflydalley

0045450 (Phosphotyrosine protein) phosphatases II 38-328 4.7e-64 212.4 In-house 41-303 (307) alignment
Range on Protein: 38-328
Range on HMM: 41-303/307.0
VNSRWSLGVSIEPRNDARNRYVNIMPYERNRVHLKTLSG----NDYINASYVKVNVP---GQSIEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVM
|   ..  ..  | |  .|||..|.||...||.|..|.|    .||||||||.|...   .  . .  .||||||. .|.. ||.|....   .  ||||
vfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweq...gvtvivm

VTPLVEYNREKCYQYWPRGGVDDTVRiaskwespggandmtqfpsDLKIEFVNVHKvKDYYTVTDIKLTPTdPLVGPVKTVHHFYFDLWKDMNKP---EE
.|.|||..||||.||||  |   | .                   ........... .|.|||. ...|..    |.. ||.||..  | |.. |   ||
ltelvelgrekcaqywPdegeeltyg...................nftvtllseeh.ldgytvrtlevtdl.dgtgesrtvthfhytgwpdhgvppsfee

VVPIMELCAHSHSLNSRGNPIIVHCSAGVGRTGTFIALDHLMHDTLDFKN---ITersrhsdrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHA
.. ..|.. . .. ...|.|..|||||||||||||||.. ...   . .    ..                 ....| .||.||...||. .|. |.|.|
lldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvd.................lleavkllreqRpgavqnpeqyrflyea

AKYL
...|
llel

0039614 (Phosphotyrosine protein) phosphatases II 46-329 1.8e-62 206.9 In-house 50-289 (297) alignment
Range on Protein: 46-329
Range on HMM: 50-289/297.0
VSIEPRNDARNRYVNIMPYERNRVHLKTLSG----NDYINASYVkvnvPGQSIEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNReK
..  | |  .|||..|.||...||.||.. |    .||||||||    .| .. .  .||||||. .|.. ||.|....   .  ||||.|.|||..| |
iallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyv....dgydlltrkfIatqgPlpetvedFwrmvweq...gvtvivmLtklvelgr.k

CYQYWPRGgvddtvriaskwespggaNDmtqFPSDLKIEFVNVHKvKDYYTVTDIKLTPTDPLvgpvKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSL
|.||||                     .      |.......|.. .|.|||. ...|....     .||.|| .  | |.. |. .  ..|..   .. 
caqywpee..................gg...tygdftvtllkveh.ldgytvrtlevtnnges....rtvthfqytgwpdhgvppslellleflelvrea

NS---RGNPIIVHCSAGVGRTGTFIALDHL-----MHDTLDfknitersrhsdrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHAAKYLN
..   .|.|..|||||||||||||||.. .      . ..|                      ....| .||.||...||| .|. |.|.|...| 
laelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvd......................vleavkelreqRpgavqtpsqyrflydallell

0047943 (Phosphotyrosine protein) phosphatases II 45-327 1.4e-61 203.8 In-house 31-270 (273) alignment
Range on Protein: 45-327
Range on HMM: 31-270/273.0
GVSIEPRNDARNRYVNIMPYERNRVHLkTLSGNDYINASYVkvNVPGQSIEpgyYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQ
 |.. |.|  .||| .|.||...||.| . .|.||||||||  ... .. .   .||||||. .|.. ||.|....   .  ||||.|.||| .||||.|
svallpenkdknrykdilpydhsrvkl.gdggsdyinAsyv..dgynlkrk...fiatqgPlpntvedfwrmvweq...nvrviVmLtelvelgrekcaq

YWPRGgvddtvriaskwespggANDMTQFPSDLKIEFVNVHKvKDYYTVTDIKLTPTDplVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLNS-
|||                    .....   ........... ||.|||. ..||...   | ..||.||..  | |.. |. . ...|.. . .. .. 
Ywple.................ggelsltygkftvtllseet.kddytvrtleltnlg..tgesrtvthfhytgwpdhgvppslesllefielvrkalea

--RGNPIIVHCSAGVGRTGTFIALDHLMHDTLDFKNITersrhsdrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHAAKY
  ...|..|||||||||||||||||.|..     ....                 ....| .|||||. |||| .|..|.|.|. .
lpsngpvvVHCsaGvgRtgtfialdllldqlekeggvd.................vleavkllrsqRpgmvqtpeqyrflyealle

0036941 (Phosphotyrosine protein) phosphatases II 46-328 2.1e-61 203.2 In-house 33-276 (297) alignment
Range on Protein: 46-328
Range on HMM: 33-276/297.0
VSIEPRNDARNRYVNIMPYERNRVHLkTLSGNDYINASYVkvNVPGQSIEpgyYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQY
|.. |.|  .||| .|.||...||.| . .|.||||||||  ...... .   .||||||. .|.. ||.|....   .  ||||.|.|||..||||.||
vallpenleknRykdilpydhtRVkl.ddegsdYinAsyv..dgydlkrk...fIatqgPlpntvedFWrmvweq...nvtvIvmltelvelgrekcaqy

WPRGgVDDTVRIASkwespggandmtqfpsdLKIEFVNVHKV-KDYYTVTDIKLTPTdpLVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLNS-
||   .....                     .......|..| .|.||.. ...|.|    |...||.||..  | |.. || . ......   .. .. 
wple.egesltygd.................ftvtllsvevvllddytlrtlevtdt..gngesrtvthfhytgwpdhgvpespaslldfielvrkvlkl

--RGNPIIVHCSAGVGRTGTFIALDHL--------MHDTLDfknitersrhsdrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHAAKYL
  .|.|..|||||||||.|||||.| .        .. ..|                      | ..|..||.||. .||| .|..|.|.|  .|
lpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvd......................ileavkklReqRpgavqtleqyrflyeallel

0043336 (Phosphotyrosine protein) phosphatases II 46-327 3.2e-60 199.3 In-house 39-275 (278) alignment
Range on Protein: 46-327
Range on HMM: 39-275/278.0
VSIEPRNDARNRYVNIMPYERNRVHLKTLSG---NDYINASYVkvnvPGQSIEPGyYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKC
... | |  .|||..|.||...||.|. |.|   .||||||||    .| .. .. .||||||. .|.. ||.|....   .  .|||.|.|||..|.||
iallpenkdknrykdilpydhsrvklsllggdldsdYinAsyv....dgynvprk.fiatqgPlpetvedFwrmvwel...gvttivmLtelvelgrvkc

YQYWPrggvDDTVRIASkwespggandmtqfpsdLKIEFVNVHKvKDYYTVTDIKLTPtdPLVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLN
.||||    ......                   .......... .|.|||.....|.     |...||.|...  | |.. || . ......   .. .
aqYwp....ggsltygd.................ftvtllkeeh.lddytvrtlevtn..lgdgesrtvthyhylgwpdhgvpeslsllldflkavreal

S-RGNPIIVHCSAGVGRTGTFIALDHLM-----HDTLDfknitersrhsdrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHAAKY
. ...|..||||||||||||||||. |.     . ..|                      .|..| .||.||...||| .|. |.|.|...
edsngpvlVHCsaGvgRTGtfialyllleqlekeggvd......................leeavkelreqRpgavqtpsqyrflyealle

0045098 (Phosphotyrosine protein) phosphatases II 49-328 4.1e-60 198.9 In-house 30-271 (278) alignment
Range on Protein: 49-328
Range on HMM: 30-271/278.0
EPRNDARNRYVNIMPYERNRVHlktlsgnDYINASYVKVNvpgqsiePGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQYWPR
 . | ..|||..|.||...||.       |||||||...        |  .||||||. .|...||.|....   .  ||||.|.|||..||||.|||| 
ylgnldknRykdilpydhsrVk.......dYINAsyidgy.......pkkfIatqgPlpstvadfwrmlwel...gitvivmltelvelgrekcaqywpe

ggvDDTVRIaskwespggandmtqfpSDLKIEFVNVHKVkDYYTVTDIKLTPT--DPLVGPVKTVHHFYFDLWKDMNKPEEV--VPIMELCAHSHSLNS-
   ......                  |......... . |.||......| .   .  ..  .|.|...  | |.. |..    .. ||.   .. .. 
...ggslty.................gdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkl

-------------RGNPIIVHCSAGVGRTGTFIALDHLMHD---TLDfknitersrhsdrateeytrdlIEQIVLQLRSQRMK-MVQTKDQFLFIYHAAK
             .|.|..||||||||||||..|.. ...    ..|                      ....| .|||||.  .||...|. |.|... 
laslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvd......................lleavkelrsqRpglavqnleqyrflyefll

YL
.|
el

0042113 (Phosphotyrosine protein) phosphatases II 48-328 3e-58 192.5 In-house 5-242 (245) alignment
Range on Protein: 48-328
Range on HMM: 5-242/245.0
IEPRNDARNRYVNIMPYERNRVHLKTLSG---NDYINASYVkvnvPGQSIEPGyYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQ
. | |  .|||..|.||...||.|.  .|   .||||||||    .|  | |. .||||||...|.. ||.|....   .  .|||.|...|..|.||.|
llpenkdknrysdilpydhtrvklspdggdldsdyinasyv....dgyritpk.fiatqgPlpetvedfwrmlwel...gittivmLteeeelgrvkcaq

YWPRggvDDTVRIaskwespggandmtqfpSDLKIEFVNVHKvKDYYTVTDIKLTPTdpLVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLNS-
|||    ......                  |.......... .|.|||. ...|..    .....|.|...  | |.. |. .  . ...   ..  . 
ywpl...geslty.................gdftvtllseeh.lddytvrtlevtnl..gddesrevihyhylpwpdhgvpdllellldflefvrkalae

-RGNPIIVHCSAGVGRTGTFIALDHLM-----HDTLDfknitersrhsdrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHAAKYL
 ...|..|||||||||||||||.. ..     . ...                      .|..| .|||||...||| .|. |.|.|...|
dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvs......................leeavkelrsqRpgavqtpsqyrflyeallel

0037934 (Phosphotyrosine protein) phosphatases II 48-327 4.4e-58 192.0 In-house 6-240 (243) alignment
Range on Protein: 48-327
Range on HMM: 6-240/243.0
IEPRNDARNRYVNIMPYERNRVHLktlSGNDYINASYVKVNvPgqsiepgYYIATQGPTRKTWDQ----FWQMCYHNcplDNIVIVMVTPLVEYNREKCY
. | |  .||| .|.||...||.|   .|.|||||....|  |       ..||||||. .|...    ||.|....   .  ||||.|.|||..||||.
llpenlsknrysdilpydhsrvkl...egsdyinanliyvt.p.......rliatqgPlpetveddlasfwrmlwel...gitvivmltelvElgrekca

QYWPrggvddtvriaS-----KwespggandmtqfpsdLKIEFVNVHKvKDYYTVTDIKLTPtDPLVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHS
||||           .     .                .........  .|.|||. ..|..  .| .....|.|...  | |.. |... ...... . 
qywp...........gevtygd................ftvtllseeh.lddytvrtlllen.ldlddltrlvihyhylpwpdhgvPdspedlldfldev

HS---------LNSRGNPIIVHCSAGVGRTGTFIALDHLMHD-TLDfknitersrhsdrateeytrdlIEQIVLQLRSQRMK-MVQTKDQFLFIYHAAKY
..          ...|.|..||||||||||||.||.. ...  ..|                      .|..| .||.||.  .||| .|. |.|.|...
refieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvd......................leeavkllreqRpgkavqtpsqyrflyealle





subfamily_PTPRB_pd Subfamily PTPRB 38-324 8.5e-58 190.7 In-house 37-280 (293) alignment
Range on Protein: 38-324
Range on HMM: 37-280/293.0
VNSRWSLGVSIEPRNDARNRYVNIMPYERNRVHL---KTLSGNDYINASYVkvnvPGQSIePGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPL
|..  .  .. ...|.|.||| ||.||. .||.|   |. ||.|||||.|.    ||..  |  .||||||  .| |.||.|.. .      .|||.| |
vgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyi....pgyns.prefiatqGPlpetvddfWrmvwek...kssiivmltql

VEYNREKCYQYWPRGgvddtvriaskwespgganDMTQFPSDLKIEFVNVHKVKDyYTVTDIKLTPtdplVGPVKTVHHFYFDLWKDMNKPEEVVPIMEL
||  ..|| .|||.                    . ...  |.|...|. ....| ... ..|..         ..|... |  | | . ||.  .....
vekgkvkCeeYWPad...................eepvlyGdikvtlvaeeeled.wvirelkiek....ekeerkvrqyhftsWpdhgvPektktlldf

CAHSHSL---NSRGNPIIVHCSAGVGRTGTFIALDHLMHDTLDfknitersrhsdratEEYTrDlIEQIVLQLRSQRMKMVQTKDQFLFIYHA
. . ..    ... .||.|||||||||||||||||.|...  .               |.|  | |  || .||..|. .|||..|..||...
vrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaiee...............edyv.d.ifgivaelReeRnllvqtekqYifihqc

0040439 (Phosphotyrosine protein) phosphatases II 49-327 4.8e-57 188.7 In-house 8-244 (249) alignment
Range on Protein: 49-327
Range on HMM: 8-244/249.0
EPRNDARNRYVNIMPYERNRVHLKTLSG---NDYINASYVKVNVPGQSiepgyYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQY
 | |  .|||..|.||...||.|. |.|   .|||||||...   ..      .||||||. .|.. ||.|....   .  ||||.|.|||..||||.||
lpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr.....fiatqgPlpetvedfwrmlwel...gitvivmLtslvelgrekcaqy

WPRggvDDTVRIaskwespggandmtqfpSDLKIEFVNVHKvKDYYTVTDIKLTPTdpLVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLNS--
||    .... .                  |.......|.. ||.|||. ..||..    |.. ||.|...  | |.. |. . ......   .. ..  
wpl...ggsley.................gdftvtllsvev.kddytvrtleltnl..ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel

-RGNPIIVHCSAGVGRTGTFIALDHLMHDTLDFKNITersrhsdrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHAAKY
 .|.|..|||||||||||||||.. ...     ....                 .|..| .|||||...||. .|. |.| |...
pkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvd.................leeavkllrsqRpgavqnpeqyrflyealle

Y_phosphatase Protein-tyrosine phosphatase 52-324 4.5e-56 185.3 Pfam-A 1-232 (235) alignment
Range on Protein: 52-324
Range on HMM: 1-232/235.0
NDARNRYVNIMPYERNRVHLKTLSG-NDYINASYVkvnvPGQSiEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQYWPrgg
|  .||| .|.||...||.||  .| .|||||.||     | . |.  .||||||. .| ..||.|....   .  ||||.| |.| .|||| ||||   
nkkknRykdilpydktrvklkgsegpsdYInAnyv....kgyk.ekkkfIatQgPlkstiedFWrmvwqe...kvkvivmltsleekgrekcaqYwp...

vddtvriaskwespgGANDMTQFPSDLKIEFV-NVHKVKDYYTVTDIKLTPTDPLVgPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLN-SRGNPI
                ... ..   |.|.| . .... .. ||.....|. ..      ..|... .  |.| . ||.. ....|.   .. . .. .|.
...............eeeeesltygdikvelkekekedekeytlrklelkkkkees.ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpv

IVHCSAGVGRTGTFIALDHLMHDTLDfknitE-RsrhsdrateeytrDLIEQIVLQLRSQRMKMVQTKDQFLFIYHA
.|||||||||||||.||| |..   .     |                 . ||| .||.||..|||. .|. |.|.|
vVhCsaGvgRtgtfvaldilleqlea.....eee.............vdvlqivkelRkqRpgmvqsleqYiflyka

Y_phosphatase Protein-tyrosine phosphatase 52-324 4.5e-56 185.3 In-house 1-232 (235) alignment
Range on Protein: 52-324
Range on HMM: 1-232/235.0
NDARNRYVNIMPYERNRVHLKTLSG-NDYINASYVkvnvPGQSiEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQYWPrgg
|  .||| .|.||...||.||  .| .|||||.||     | . |.  .||||||. .| ..||.|....   .  ||||.| |.| .|||| ||||   
nkkknRykdilpydktrvklkgsegpsdYInAnyv....kgyk.ekkkfIatQgPlkstiedFWrmvwqe...kvkvivmltsleekgrekcaqYwp...

vddtvriaskwespgGANDMTQFPSDLKIEFV-NVHKVKDYYTVTDIKLTPTDPLVgPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLN-SRGNPI
                ... ..   |.|.| . .... .. ||.....|. ..      ..|... .  |.| . ||.. ....|.   .. . .. .|.
...............eeeeesltygdikvelkekekedekeytlrklelkkkkees.ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpv

IVHCSAGVGRTGTFIALDHLMHDTLDfknitE-RsrhsdrateeytrDLIEQIVLQLRSQRMKMVQTKDQFLFIYHA
.|||||||||||||.||| |..   .     |                 . ||| .||.||..|||. .|. |.|.|
vVhCsaGvgRtgtfvaldilleqlea.....eee.............vdvlqivkelRkqRpgmvqsleqYiflyka

subfamily_PTPRD_pd Subfamily PTPRD 43-325 7e-55 181.7 In-house 39-277 (564) alignment
Range on Protein: 43-325
Range on HMM: 39-277/564.0
SLGVSIEPRNDARNRYVNIMPYERNRVHLKTLSG---NDYINASYVKvnvpGQSiEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNR
.  .. .| | |.||| ||..|...|| |... |    ||||||...    |   ..  |||||||. .| . ||.|.. .   .  .|||.| |.| ..
tweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfid....gyr.krkayIAtqgPlaetiedFWRmvweq...nsstiVmltkleEkgk

EKCYQYWPRGGVDDTVRIASKWESPGGANDMTQfpSDLKI---EfvnvhkvkdyytvtdikltptdplVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCA
.|| .|||  |     ..  . |.    .|..    ..|.   .                           ...|..|.|  | | . ||.  ....|  
vkchkYWPekgtetygeltVtleeeeeladyei..rtfklkkkk........................ssesreVrqFhFtsWPdhgvpesatslLdlir

HSHSLNSRGN-PIIVHCSAGVGRTGTFIALDHLMhdtldfknitersrhsDRATEEYTRDlIEQIVLQLRSQRMKMVQTKDQFLFIYHAA
....||.... ||.||||||||||||||..| ..                .|..|| | | | |.| .||.||  ||||..|. ||..| 
kvralnepdagPivVhCSaGVGRTGtfividaml................erikeektvD.iyqyvkalrkqRnamVqteeQYiFiheai

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 51-325 5.9e-52 171.4 In-house 27-264 (274) alignment
Range on Protein: 51-325
Range on HMM: 27-264/274.0
RNDARNRYVNIMPYERNRVHLKTLSG----NDYINASYVKvnvpGQSIEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQYW
..  .||| .|.| |. || |.. |.     .|||| |.|    | . |   |.|||||  .| ..||.| |..   .  ||||.| | | |..|| .|.
gsqtknryktilPnensrvllesessededssyinanyik....GydeeskayvatqGPlpntvadfWrmiyqe...evqvivmltklkeaneqkCavyf

PrggvddtvriaskwespgGAN--DMTQFPSDLKIEFVNVHKVKDyYTVTDIKLTPTDPlvgpVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLNS-
|                   |.  ....   |..|..... . .| |.|. . |  .       ..|.|...  | |.. |... ....|... .. .. 
P..................daedyeiserygdveikvekivernd.ysvrklvlkyler....ersvkhywytdWPdhksPddantlldlvleveesree

---RGNPIIVHCSAGVGRTGTFIALDHLMHDTLDfknitersrhsdrateEYTRDLIeQIVLQLRSQRMKMVQTKDQFLFIYHAA
   .  |..||||||.|||| ||| .  ...  .                | . |.. .|| .|| .|  ||||..|. .|..| 
enaklapvvvhCsaGiGrtGcfiaisiavrqlre................eivvdvl.kivcnlrldrGGmvqtseqyelihral

subfamily_PTPN13_pd Subfamily PTPN13 51-327 5e-49 162.0 In-house 36-267 (273) alignment
Range on Protein: 51-327
Range on HMM: 36-267/273.0
RNDARNRYVNIMPYERNRVHLKTLSGndYINASYVKVNVpgqSIEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQYWPRgg
.| ..||| |..||.. ||.|.  .|  |||||..||.|     .   |||.|||  .| . |||| .     .  ||.|||  .| .. || .|||   
enkdknryrnvlPydetrvklgdegg..yinaslikvpv...gkdeyeyiacqGPlPetvkdfwqmvweq...kaeviamvtlekekgkvkchrywPe..

vddtvriaSkwespggANDMTQFPSDLKIEFVNVHKVKDyYTVTDIKLTptDPLVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLNSRGNPIIV
        |       .|. ..  . |..| ..| | .. ..| .....  |   | .. | |. |  | | . | . ...... |.  .|..   ||.|
........s.......knkklkvsnrlevellkvqkldg.fvvralavk..dsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivv

HCSAGVGRTGTFIALDHLmhdtldfKNITERSRhsdrateeytRDLIEQIVLQLRSQRMKMVQTKDQFLFIYHAAKY
|||||.||.||.|..| .        .. || .             ...|| .|| ||  .||||||..|.|.|. .
hcsaGiGrsGtlitidvv.......lglierdk..........efdvkeivrklreqrqgvvqtkdqyifvykaile

subfamily_PTPN6_pd Subfamily PTPN6 46-327 5.6e-49 161.8 In-house 48-295 (306) alignment
Range on Protein: 46-327
Range on HMM: 48-295/306.0
VSIEPRNDARNRYVNIMPYERNRVHL--KTLSGNDYINASYVKVNVPGQSiepGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCY
 .  |.|  .||| ||.|.. .|| |  . ..|.|||||.|.| .|.|..    .||||||  ..|  .||.| . .   .  ||||.|  || ..|||.
egakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsd...ksyiatqgclettvsdFWrmvwqe...nsrvivmttkevErgkekCa

QYWPRGGVDDT---VRIASKWESpggandmtqfpsdlkiefvnvhkVKDYYTVTDIKLTPTDPlVGPVKTVHHFYFDLWKDMNKPEEVVPIMELC----A
.|||    ...   ... .  |.                        ...|.. ..... ..   .  ..|... |  | | . |..   ....     .
rYWPdeeekeeyGkisvtnvsek.......................sladYilRelsvskkkk.kkeerevfqyhfksWPdhgvpkdpgavLdfledvnr

HSHSLN-SRGNPIIVHCSAGVGRTGTFIALDHLMhdtldfKNITERSRhsdrateEYTRDlIEQIVLQLRSQRMKMVQTKDQFLFIYHAAKY
....|. ..  ||.||||||.||||||| .| |.      |.|...         ..  | |...| ..|.||  .|||..|. |.|.| |.
kqeeleeaeagpivvhCsaGiGRtGtfiviDill......kliekkgl.......dadid.iqklvksvreqrsglvqteqqykfvykaikk

subfamily_PTPRG_pd Subfamily PTPRG 37-324 2.8e-46 152.9 In-house 32-282 (563) alignment
Range on Protein: 37-324
Range on HMM: 32-282/563.0
TVNSRWSLGVSIEPRNDARNRYVNIMPYERNRVHLKTLSG---N-DYINASYVKVNVPGQSiepgyYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVT
|...      | .| |  .|||.||..|.| ||.|. |.|   . |||||.|..    ..      .|||||| ..| | ||.| . .      .|||.|
tiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkska.....fiatqgplkdtfddFWrmiWeq...nvaiivmit

PLVEYNREKCYQYWPRGGVDDTVRIASKWESPGGANDMTQFpsdlkiefvnvhkvkdYYTVTDIKLTPTDPlVGPVKTVHHFYFDLWKDMNKPEEVVPIM
 ||| .|.|| .|||. .. .   .  . ..       |.                   .. ..||  ..     .|.| .. .  | |.. ||  .| .
nlvergrrkcdvYWPkdesetygalqvtlieeevlalytvr................tlviknlklkkkkq.cdteklvrqyhytkWPdhgvPehslpvL

ELCAHSHSLNSR-GNPIIVHCSAGVGRTGTFIALDHLMHDtLDFKNITErsrhsdrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHA
    .|   | .   ||.||||||||||||.|.|| |... .  .|. .                . ... ..|.||  .|||..|..|.. |
ifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkq.iqqenavn................vfgflkhiraqRnflvqteEqYiflhda

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 44-330 3e-46 153.0 In-house 48-292 (298) alignment
Range on Protein: 44-330
Range on HMM: 48-292/298.0
LGVSIEPRNDARNRYVNIMPYERNRVHLKTL---SGNDYINASYVKvNVPGQSiepgYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNRE
  |. .|.|  .||| .|....  || |..       ||||||... .  |..     .||||.|  .|  .||.|  ..   |  .|||.|.|.| .. 
kevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflh.aykgrn....afiatqaPltetvedFWrmvtee...digtiVmltnleeldkt

KCYQYWPRGGVD--DTVRIaskwespggandmtqfpsdlkiefvNVHKVKDYYTVTDIKLTPTDPLVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHS
|. .|||  | .  .....                         .... ...  ..  ||. ..  .   ..|... |  | |   ||.   ...| .. 
kyhkywPdegketygeitv.........................sllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkv

HSLNSRGN--PIIVHCSAGVGRTGTFIALDHLMhdtldfknitersrhsDRATEEYTRDlIEQIVLQLRSQRMKMVQTKDQFLFIYHAA-KYLNS
.  ...    |.||.|||||||.|||||.| ..                .|. .| . | . |.|  || .|...|||..|. |||.|  ..|.|
rasqqqagnkpvivqCsaGvgRsGtfiaidsvl................ervkkeqvvD.vfqvvkvlRkkrpgavqteeqYvfiyeavlealds

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 51-326 4.5e-46 152.0 In-house 19-261 (270) alignment
Range on Protein: 51-326
Range on HMM: 19-261/270.0
RNDARNRYVNIMPYERNRVHLKTLSGN---DYINASYVKvnvpGQSIEPGYYIATQGPTRKTWDQFWQMCYHNCPldnIVIVMVTPLVEYNREKCYQYWP
|. . ||| .|.|  . || |..|. .    |||| ||.    | . |. .|||..||.  |  .||.| ...       |||.|.|.| .|.|| .|||
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvr....GfdgekkkYiaamgPlpttlksfwrmiweekv...taivmttgleEkgrkkCerYWp

RggvddtvriaskweSPGGANDMtqfpSDLKIEFVNVHKVK-DYYTVTDIKLTpTDplvGPVKTVHHFYFDLWKDMNK---------PEEVVPIMELCAH
               .|.   ..    .| ||. ......| . | .| ..|. ..   |  . . ||..  | |            ..... ...   .
a..............epkekvkl....edgkikvlalseekeegyiltrlrle.ek...geerrlvHfwyntWpdhgvpreedsslstdqllkmlravrr

SHSLNSRGNPIIVHCSAGVGRTGTFIALDHLMHdTLDfkniteRSRHSDrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHAAK
|..  ....|..||||||||||||.||||. .. .|.      .... |          . .|. .|| .||..||. .|. |.|.|  
sekeldkaePllvHcsaGvgRtGtlialDiavr.lLe......etkkvd..........vlaiieelRkdRmalvqhpeqyeflykavv

subfamily_PTPN12_pd Subfamily PTPN12 42-326 1.1e-45 150.8 In-house 30-274 (290) alignment
Range on Protein: 42-326
Range on HMM: 30-274/290.0
WSLGVSIEPRNDARNRYVNIMPYERNRVHLKTLSGN---DYINASYVKVnvPGqsiEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYN
.|  .. ...| ..||| .|.||. .||.|.. ...   |||||...|   .    ..  |||.|||  || |.||.| ..    .  ..||.  .|| .
ysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikg..ve...gkleyiaaqgPLpktlddfWrmiwek...nveivvmaCrevelg

REKCYQYWPRGGvddtvriaskwespggaNDMTQFpSDLKIEFVNVHKVKDYYTVTDIKLTPTdplvGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHS
. || .|||  |                 .. ..| ......  . ..|.| ...  .|..      .  ..|. | .  | | . |. . ...|| .. 
kkkCerYWpeeg.................eeelef.gefevtleeekavdddflirtLkveaq....kesrkvyqfhYtaWPDhgvPssaksllelielv

HSLNS-RGNPIIVHCSAGVGRTGTFIALDHLMhDTLDFKNITERSRhsdrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHAAK
..|..   .|..|||||||||||| ||.|.   . |  ..|.|.               . ..||.|| ||  .||||.|. ..|.|  
relqesedaPlvvhCsaGvGrtGtiiaidyvr.ellkaekipeeld.............vfdlvlelrkqraalvqtkeqyelvykava

subfamily_PTPRA_pd Subfamily PTPRA 49-325 4.6e-45 148.9 In-house 55-291 (330) alignment
Range on Protein: 49-325
Range on HMM: 55-291/330.0
EPRNDARNRYVNIMPYERNRVHLKTLSGN---DYINASYVKvnvpGQSiEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQY
.  |  .||.|||.||. .||.| ...|.   ||||||...    |   |  ..||.||| ..| . ||.| .     .   |||.| | | ..|||.||
keenkeknrvvnilPydfsrvilsvkeGveesdyinasfid....Gyk.ekdkfiaaqGPkeetvedfwrmiweq...ksativmltelkerkeekcaqy

WPRGGVddtvriaskWESpGgandmtqfpsDLKIEFVNVHKVKDyYTVTDIKLT--PTDPLVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLNS
||  |.         .   |          ....|  ..  ..| ||| .. ..  |      ... |. |.|  | |.  | | . ...| .. ..|| 
wPdeGl.........vty.G..........nirvevedetvlvd.ytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnq

-RGNPIIVHCSAGVGRTGTFIALDHLMHDTldfknitersrHSDRATEEYtrdlieQIVLQLRSQRMKMVQTKDQFLFIYHAA
  ..||.||||||||||||||.|| ...             ...|  . .      ..| .|| || .||||. |. |||.. 
qsagpivvhcsaGvGrtGtfivldavlerv...........kaerkvdvf......efvkrlrlqrpqmvqtdeqyefiykvl

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 47-326 4.3e-44 145.7 In-house 36-273 (281) alignment
Range on Protein: 47-326
Range on HMM: 36-273/281.0
SIEPRNDARNRYVNIMPYERNRVHL---KTLSGNDYINASYVKvnvpGQSiEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCY
| .. |  .|||.||. |.  ||..   .. . .|||||..|.    | . ..  |||||||  .. ..|||| . .   .  .|||||  .| .. ||.
skadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvp....gyk.gekeyiatqgPvPaslvafWqmvweq...kvsaivmvtreieagklkCh

QYWPRGGVddtvriaskwespggandmTQFPSDLKIEFVNVHKVKDyYTVTDIKLTPTDplvGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLNS
.||| .                     .   .|....... .. .  |    .||. ..   |. ..|... .  | |   |..   ..|  .  ..|..
rYWPddns...................elkygdvtvkstaeeekat.yierkfkleres...getreveqlaytaWPdhGvPattkellefrkevlklte

RGN--PIIVHCSAGVGRTGTFIALDHLMHDTldfkniTERSRHSDrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHAAK
. .  |...|||||||||||.|||| |..        ... .. |          ....| .|| .|. ||||  |. |.|.| .
kktkaplvihCsaGvGrtGtyialDrlvkav......eaeleeld..........vkavvaelrkernlmvqtvvqyefvykavl

subfamily_PTPN1_pd Subfamily PTPN1 42-324 6.5e-44 144.8 In-house 22-266 (290) alignment
Range on Protein: 42-324
Range on HMM: 22-266/290.0
WSLGVSIEPRNDARNRYVNIMPYERNRVHLKTLSgNDYINASYVKVNVPGQSiepgyYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREK
..  .. .|.| ..||| .. ||.  |..|.  . ||||||| |...   .|     || ||||  .| | |||| ...   .   .||.  .|| .. |
fptreaklpenrnlnryrdvspydhsriklerad.ndyinaslveleeakrs.....yiltqGPlpntvdhfWqmvWeq...kskavvmlnkvvekeqik

CYQYWPRGGVddtvriaskwespggANDMTQFPSDLKIEFVNVhKVKDYYTVTDIKLTptDPLVGPVKTVHHFYFDLWKDMNKPEE---VVPIMELCAHS
|.||||.|                  . ..   . ||.....  ..|.||||  ..|.  .      ... ||..  | |.  ||     .  .  . .|
caqywPqgee...............ekellledtklkvklise.erksyytvrllele..nlktqetreilhfhyttwpdfgvpespaaflkflfkvres

HSLNSRGNPIIVHCSAGVGRTGTFIALDHLMHDtldfknITERsrhSDRAT-EeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHA
 ||.|   | ..|||||.||.|||. .| ..        | ..    | .. .      |.. .|.||..|. ..||.||. | | |
GslssdvGpavihcsaGiGrsGtfclvdtclvl......iekk...ddlssvd......ikkvllelrkyrlGliqtadqlrfsyla

subfamily_PTPN3_pd Subfamily PTPN3 46-324 1.1e-43 144.2 In-house 35-270 (280) alignment
Range on Protein: 46-324
Range on HMM: 35-270/280.0
VSIEPRNDARNRYVNIMPYERNRVHLKTLSGnDYINASYVKVNVPGQSIEPgYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQY
..  |.| ..||| .|.||.  ||.||  .  |||||.||....|....    ||||||| .||  .|||| ...   .  .|||.| |||  | ||.||
aarkpenlsknryrdilpydatrvklkeset.dyinanyvnmeipstglvn.ryiatqGPlaktatdfWqmvweq...ksslivmlttlverGrvkChqy

WPRggVDdtvriaskwespgganDMTQFPsDLKIEFVNVhKVKDYYTVTDIKLTPTDplVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLN-SR
||.   .                | ...  .....  .  . .  | . .. |. ..      ...... .  | | . |..   ..|.  . ..|  ..
WPe..te................deleyg.efsvkceke.detksyvlrelvlkdke..tkeerkilqlqylaWpdhgvPddsadflefvervrklrsgk

GNPIIVHCSAGVGRTGTFIALDHLMHdtldfknITERsrhsdrATEEYTRDlieqIVLQLRSQRMKMVQTKDQFLFIYHA
 .|..||||||.|||| .|.|.  ..       ..|.      | . |  |    || ..| ||. .|||..|. |. .|
eePvvvhCsaGigrtGvlilletala.......liea......aepvypld....ivrtmrdqramlvqtasqykfvCea

subfamily_Ptp69D_pd Subfamily Ptp69D 46-324 5.3e-42 139.0 In-house 42-281 (307) alignment
Range on Protein: 46-324
Range on HMM: 42-281/307.0
VSIEPRNDARNRYVNIMPYERNRVHLKTLSGN---DYINASYVKVNVpgqsiEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKC
|| .  |  .||| .|......|| ||.. |.   ||||||..|        |   .|| |.|   | . ||.|       .  .|||.. | |.||.||
vsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgyk.....ekkkfiaaqdPveatigDfWRmiaeq...evtlivmlsnlteknrkkc

YQYWPRGgvddtvriaskwespgganDMTQFPsDLKIEFVNVHKVKDyYTVTDIKLTPTD---PLVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSH
 .|||                     | .|.  |. ...|. .| .| |.  ..... ..   . |   . |  . .  |||.. ||    ...|  . .
akYWpie...................devqyg.dilvklvseekhsd.yiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvr

SLNSR-GNPIIVHCSAGVGRTGTFIALDHLMHdtldfkniteRSRHSDRATeeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHA
.|..    ||.|||||||||.|.|.||| |..          . .  |..        | ..| .|||||  .||  .|. |.|.|
elyklnrsPivvhCsaGvgrsgifvaldsllq..........qlkaedkvd.......ifetvkdLrsqRnllvqsleqYvflyra

subfamily_PTPN23_pd Subfamily PTPN23 45-324 7.3e-42 138.2 In-house 36-275 (288) alignment
Range on Protein: 45-324
Range on HMM: 36-275/288.0
GVSIEPRNDARNRYVNIMPYERNRVHLKtLSGNDYINASYVKVNVPGQsiePgYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQ
 ..|  ..  .||. .|.||..|||.|.  | .||||||.||  .||    |  .||||.| ..|   ||.| |..      ||||..   | ...|. .
siaiaklyseknrsrdilPyDhnRvklr.gskDDYinAsfvkdlspgc...P.dfiatqaPlqstlnDFWlmvyeq...kssviVmllskeelgkpkvdr

YWPRGgVDDTVRIASkwespggandmtqfpsdLKIEFVNVHKVkDYYTVTDIKLTPTDPlvGPVKTVHHFYFDLWKDMNK---PEEVVPIMELCAHSHSL
|||    ..||.                    |..   .|..  ...   ..||.  |.    ||.| |  .  | ..     ||... ...   .... 
YwPed.kgetvkfgd.................lsvtlksvret.ethvervlkletlda..davksvshlqltsWpelGvPasPetllqfldevesayea

NSR--GNPIIVHCSAGVGRTGTFIALDHLMHDTlDFKNITErsrhsdrateeytrdLIEQIVLQLRSQRMKMVQTKDQFLFIYHA
. |    |..|||||||||||.|  .   .... . .|.                  | |.| .|| ||  |||.|.|. | |.|
vqrksktPlvvhCsaGvgRtgvfalvyaavrel.ekgngll...............diiqvvsrlreqRrfmvqekeqlkfsyea

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 43-325 3.7e-41 136.2 In-house 39-279 (319) alignment
Range on Protein: 43-325
Range on HMM: 39-279/319.0
SLGVSIEPRNDARNRYVNIMPYERNRVHLKTLSG---NDYINASYVKVNVpgqsiEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNR
..  . ...|  .||| ||..|.| || |..| |    ||||||..         |   .||||.|  .| . ||.| ...   .  ..||.| |||  .
tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyq.....erekfiatqaPlentiedfWrmvWee...essivvmltklveklk

EKCYQYWPRGgvddtvriasKWESPGgandmtqfpsDLKIEFVNVHKVKDyYTVTDIKLTPTDPLVGPvKTVHHFYFDLWKDMNKPEEVVPIMELCAHSH
 |. .|||.           ..|. |           | ..  . .. .| | . ..|| .    |   ..| ||..  | | . ||.   ...|  . .
vklkkywpee..........nfeeyG..........rlivtleeeeeled.yiirklklnkkssevet.RevkhfqyteWpdhdvPekatslldllkrir

SLNSR--GNPIIVHCSAGVGRTGTFIALDHLMhdtldfknitersrhsDRATEEYTRDLIeQIVLQLRSQRMKMVQTKDQFLFIYHAA
   ..    ||.||||||||||||||.||  .                .|  || . |.  ..| .|| ||  |||...|. |||.| 
ksrektqsgPivvhCsaGvGRtGtfivldaml................ervkeegvlDvf.stvsrlRtqRnimvqrpeqYkfiyeal

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 39-324 1.5e-40 133.9 In-house 33-278 (290) alignment
Range on Protein: 39-324
Range on HMM: 33-278/290.0
NSRWSLGVSIEPRNDARNRYVNIMPYERNRVHLKTLSGN-----DYINASYVKvnvpgQSIEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTP
.|  .  | . . |  .||. ||..|. ||. |. .||.     .||||.|.|     .  |   |||||||. .|  .||.. ...   .  .|||.| 
esehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyik.....gykekkqyiatqgpvsntlvdFWkliwqe...kvtiivmltn

LVEYNREKCYQYWPRGGVDDTVRIASKWespggandmtqfpsdlkiefvNVHKVKDYYTVTDIKLTPTDPLvGPVKTVHHFYFDLWKDMNKPEEVVPIME
 .| ...||.||||  ....   .  |                      .  .. ..|. . .... ..   |. ..|... .  |..  | ..   |. 
iieegkvkCqqYWpdsdtkaygefsikl.....................lneetlneyierklevknknsa.gakqsvtqyqitnwdstgkvtnpqtill

LCAHSHS--LNSRGNPIIVHCSAGVGRTGTFIALDHlmhdTLdfknitersrhsDRATEEYTRDLIeQIVLQLRSQRMKMVQTKDQFLFIYHA
. ..       .  ..|.||||..|||...|.|..     |.            ...  |   |.. |.. ..|.|....|||..|. .|.. 
vieemyktqrkrgntsivvHCSdtvgrsavfcaaat....ti............nkcktegvidvf.qvlksqRiqkpgsvqtvqqyqgifqi

0041856 (Phosphotyrosine protein) phosphatases II 52-327 2.1e-40 133.6 In-house 1-169 (182) alignment
Range on Protein: 52-327
Range on HMM: 1-169/182.0
NDARNRYVNIMPYERNRvhlktlsGNDYINASYVKVNVPGQSiepgyYIATQGPTRKTWDQFWQMCYHNcpldNI-VIVMVTplveynrekCYQYWPrgg
|  .|||..|.||...|       ..|||||...  . |..      .||||||. .|. .|..| ...    .| .||..|         ...|||   
nldknrysdilpydhsr.......dldyInanlylgslpatr.....fiatqgpllstvadflrmlkel....gittivnlt.........eelywp...

vddtvriaskwespggandmtQ-FpsdlkiefvnvhkvkdyytvtdikltptdplvgpVKTVHHFYFDLWKDMNKPEevvpIMELCAHSHSLNSRGNPII
                     . .                                   ........  | |.. |.    . ||..  .  ...|.|..
.....................ell..................................erlgiqylylpwpDhgvpd....ldelldfieevleeggpvl

VHCSAGVGRTGTFIALDHLMHDTLDfknitersrhsdrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHAAKY
||||||||||||..|.. ...  ..                      .|..| ..||.|..||.| .|. |.. |. .
VHCsaGvgRtgtlvaaylmkklgvs......................leeavklvrsrRpgmvitpnqyfflqlalle

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 50-324 3.8e-40 133.1 In-house 59-286 (319) alignment
Range on Protein: 50-324
Range on HMM: 59-286/319.0
PRNDARNRYVNIMPYERNRVHLKTLSG---NDYINASYVKvnvpG-QsiEPGYYIATQGPTRKTWDQFWQMCYH-NCpldnIVIVMVTplveynREKCYQ
..|  .||..||.....|.| |. | |    ||||||.|.    | |   .  |||.|||   | . ||.| .  ||      ||..|      ..|| |
dqnkdknriinilafdknvvklerliGeefsdyinasfvt....Gyq..rkdkyiaaqGPldntladfWrmiweync....stivllt......kdkcsq

YWPRGGVDDTVRIASKWESPGGANDmtqfpsdlkiefvnvhkvkdyYTVTDIKLTPtDPLVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAH---SHSL
|||  .|    |   | .|   ...                     |.| ||.|.  |     .. .. |.|  | |. .|.  ...| |  .    .| 
ywplkivikeerfkvkvdsveetae.....................yvvrdielse.dgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltsk

NSRGNPIIVHCSAGVGRTGTFIALDHLMhdtldfknitersrhsDRATEEYTRDlIEQIVLQLRSQRMKMVQTKDQFLFIYHA
.   ..|.|||||||||||..|.|| |.                ||  ||   | . ..| .|| || ..||   |. ||| |
enhranivvhcsaGvGrtGvyivldvll................drmkeekqvd.vynfvrdlrqqrntlvqdlvqykfiysa

0051429 (Phosphotyrosine protein) phosphatases II 74-327 9.6e-40 132.3 In-house 1-223 (272) alignment
Range on Protein: 74-327
Range on HMM: 1-223/272.0
LSGNDYINASYVKVNvpGQSIEPGYYIATQGPTRKTWDQFWQMCYHNCPldniVIVMVTPLVEYNREKCYQYWprggvddtVRIASKWESPGGANDMTQF
|. ..||||..|. .  |. . ||......||.. |...||... ...     .||......|..|.||..||          |   . .  .  ..| .
lplsgyiNardvggy..grvvkpgrlyrsggplpltaadfwrlkelgik....tivdLrseeErgrlkcdryw........pgirylhlpilddsaptil

PSDLKIEFVNVHkVKDYYTVTDIKLTPTDPLVGPvKTVHHFYFDLWKDMNKP-EEVVPIMELCAHshslnsrGNPIIVHCSAGVGRTGTFIALDHLMhDT
  .| . .. .. ....|... . || . .   .  .|.|...  | |.. | |... ..||...       |.|..||||||..||||..||..|.   
ygalrvtllsee.llldyilrellltlllsagea.revmhlhytdwpdhgvpqeallellellld.......ggpvlvHCsaGkdRTGtvvalllll.lg

LDFKNITERSRHSDRAteeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHAAKY
..   | .  . .. .        .|..| .||.||...||| .|.||.|.|.. 
vsletivddYlltnly........leeaveelraqrpgavqteeqylflyealle

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 50-324 1.8e-39 131.0 In-house 23-250 (284) alignment
Range on Protein: 50-324
Range on HMM: 23-250/284.0
PRNDARNRYVNIMPYERNRVHLKTLSG---NDYINASYVKvnvpG-QsiEPGYYIATQGPTRKTWDQFWQMCYH-NCpldnIVIVMVTplveynREKCYQ
..|  .||...|.....|.| |. | |    ||||||...    | |   .  |||||||   | . ||.| .  ||      ||..|      ..|| |
dqnkdknrighilafdknvvklerliGeefsdyinasfit....Gyq..rkdkyiatqGPldntladfWrmiweync....stivllt......kdkcsq

YWPRGGVDDTVRIASKWESPGGANDmtqfpsdlkiefvnvhkvkdyYTVTDIKLTPTDpLVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAH---SHSL
|||  .|    |   | .|   ...                     |.| ||.|.        ..... |.|  | |. .|.  ...| |  .    .| 
ywplkivikeerfkvkvdsveesee.....................yvvrdielsedg.kekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltsk

NSRGNPIIVHCSAGVGRTGTFIALDHLMhdtldfknitersrhsDRATEEYTRDlIEQIVLQLRSQRMKMVQTKDQFLFIYHA
.   ..|.|||||||||||..|.|| |.                ||  ||   | . ..| .|| || ..||   |. ||| |
enhranivvhcsagvgrtgvyivldvll................drmkeekqvd.vynfvrdlrqqrntlvqdlvqykfiysa

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 44-325 1.5e-38 127.7 In-house 38-279 (305) alignment
Range on Protein: 44-325
Range on HMM: 38-279/305.0
LGVSIEPRNDARNRYVNIMPYERNRVHLKTLSGND---YINASYVKvnvpGQSiEPGYYIATQGPTRKTWDQFWQMCYHNCPldnIVIVMVTPLVEYNRE
. |  .  | |.||...|.... .|..|.. . .|   |||||||.    | . .   ||..||| ..| ..||.. ..  .    .|||.| ||| ...
idvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvd....gyk.rkkkyivaqgPlkntvadfWrliveekv...stivmltklveggkd

KCYQYWPrggvddtvriaskwESpggANDMTQFpSDLKIEFVNVHKVKDYyTVTDIKLTPTDPlVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSH-
||.||||              ||    .. ..|  ....|  . ....|| .  ..|..  |      .|| .. .  | |   |..   ...|  . . 
kCrqYWp..............es...ktekkef.gefsvelksektasdy.ieRklkisiede.dkesrtvlqyqltdWPdhGvpqfatsllslikrvqk

-SLNSRGNPIIVHCSAGVGRTGTFIALDHLMhdtldfknitersrhsDRATEEYTRDLIeQIVLQLRSQRMKMVQTKDQFLFIYHAA
   ...| |..|||||||||||.|||.|  .                .|. .| . |.  ... ||||.|||||||.||. |.. | 
dqkkdkgvpllVhCsagvgRtGvfiavdial................erlkkEevvdvf.evlkqlRskrmkmvqtldqYvflhdal

subfamily_PTPRK_pd Subfamily PTPRK 14-325 2.3e-38 126.8 In-house 8-273 (314) alignment
Range on Protein: 14-325
Range on HMM: 8-273/314.0
DLLGKFKFIQNQEDGRLREATNGTVNSrWSlgVSIEPRNDARNRYVNIMPYERNRVHLKTLSGN---DYINASYVkvnvpGQSIEPGYYIATQGPTRKTW
||| . . ..  |   ..|  .  ..  |   .. .  | ..||. .|..|.| || |.|. |.   |||||...          |  .|.|||| ..| 
dllqsiallkraegygfkeeyeslfeg.wd..aakkdenreknrsgdilaydrsrvflitidgdpssdyinaali.....dsykrpaafivtqgPlqetv

DQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQYWPrggvddtvriaskwespgganDMTQFPSDLKIEFVNVHKVKDYYTVTdIKLTPTDPLVGPVKT
  ||.. |..   .   |||.| |||  | ||..|||                     . |.   |.|.|.|...  ... . .  ... .   .  ...
kdfWrlvyde...ncasivmltelvevgrvkClkyWP.....................edtevygdikvelvetellaelvvri.frveklargqeeire

VHHFYFDLWKDMNKPEEVVPIMELCAHSHSLNSRG-NPIIVHCSAGVGRTGTFIALDHLMhDTLDFKNITErsrhsdrateeytrdlIEQIVLQLRSQRM
|..| |  | | . | .   ...| .. .. .  .  .|.|||||| ||||||||.| .. | .. ... .                . ..| .|||...
vrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivl.dmieregvvd................vfnavktlrsrkv

KMVQTKDQFLFIYHAA
 ||.|..|. ||| ..
nmveteeqykfiydvi

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 47-329 1.1e-37 124.6 In-house 4-243 (250) alignment
Range on Protein: 47-329
Range on HMM: 4-243/250.0
SIEPRNDARNRYVNIMPYERNRVHLKTLS---GNDYINASYVKVNVpgqsiEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREkCY
. .|.|  .||| .|....  || |.. .     ||||||....       |   .||||||  .|  .||.| ...   .  .|||.| |.| ... . 
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyd.....erkafiatqgPlqatiedfWrmvlee...ksgtivmLtnLkesekt.yh

QYWPrggVDDTvriaSKWespGgandmtqfpsDLKIEFVNVHKVKDyYTVTDIKLTPTDPlvGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLNS
||||   |. .     |.   |          |....  . ..  | ||.. .||. .       ..| .. |  | |   ||.   ..||  . .. . 
qywP...veka....eky...G..........dvtvsllskeefad.ytkrklklskakk..aderivrqlhfvvWPdkgvPevatavLellkkvqasqq

R--GNPIIVHCSAGVGRTGTFIALDHLMhdtldfknitersrhsDRATEEYTRDlIEQIVLQLRSQRMKMVQTKDQFLFIYHAA-KYLN
.   .|.||.|||||||.|.|||.| ..                .|. .| . | . ... .|| .|...|....|. |.|... |.|.
qagnaPvivqCsaGvgrsGafiaidavl................erlkkekvvd.vfkvikvlrkdrphavesleqyvfvyeiilkald

subfamily_PTPN14_pd Subfamily PTPN14 47-327 7.2e-37 122.0 In-house 44-295 (300) alignment
Range on Protein: 47-327
Range on HMM: 44-295/300.0
SIEPRNDARNRYVNIMPYERNRVHLKTLSG--NDYINASYVKVNVPGQSIEpgyYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQ
.  | |  .||. ...||| |||.|..     ..||||| .|| | |.. .   ||..||| ..|  .|||| . .   .  .|||.|   |  .||...
aklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkers...yivaqgPleltvqdfWqmvWeq...gvqlivmlteeeedgkeksfk

YWPRGGVDDTvRIaskwespgganDMTQFpsDLKIEFVNvhKVKdYYTVtdIKLTPTDPLVGPVKTVHHFYFDLWKDMNKPEEVVPIME-------LCAH
|.|. .     ..           .  .|   .  .|..  . .  ..   ..|.    . .  .||.|. .  | | . ||.| . ..       .. .
yfPkleskkk.tv...........efgkf..kvttkfse..dsd.svit..tglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrk

SHSLN---SRGNPIIVHCSAGVGRTGTFIALDhLMHDTLDFKNITErsrhsdrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHAA-KY
..| .   ..  |..|||||||||||  |  | |.  ||.  .  .                |.... .|| ||| .|||  |. |.|..  ||
tnseveskeskPPvlvhCsaGvGrtGvlilsd.lliatlehneeid................ikkvlarLreqrmllvqtlaqYkfvYkvliky

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 50-325 1.2e-36 121.0 In-house 31-262 (283) alignment
Range on Protein: 50-325
Range on HMM: 31-262/283.0
PRNDARNRYVNIMPYERNRVHLKTLSGnDYINASYVKVNVPGQsiEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQYWPRG
 .|.  ||. .|.|....||.||..|  |||||... |.   .  .   ||..|.| ..|   ||.| ...   .   |||.|.| | .|.|| ||||. 
denkrknrnqeivpadqwrvelksesr.dyinavfipvsksyk..qdkkyiiaqsPldrtvvdfWkmvfde...kitaivmltklqedlrikCsqyWPkr

GVDDTVRIASKWESPGGANDMTQFPSDLKIEfvnvhkvkdyytvtdikltptdP-----LVgpvktVHHFYFDLWKDMNKPEEVVPIMEL-CAHSHSLNS
|  |    .   .   . | ...    |. .                            |.     . |. .. | ....   .  .. .    |   .|
GsedyGeftvtlrkettsnsfiikelllrvn......................ssakstll.....lahyqvidWleygeqaiinslvkfnkvislqtes

RGNPIIVHCSAGVGRTGTFIALDHLMHDTLdfknitersrhsdratEEYTRDlIEQIVLQLRSQRMKMVQTKDQFLFIYHAA
.  ||.||||.|.|||..|||.   ..| |                 |   | . ..|  .| ||| .|||.||. ......
kkgPivvhCstgiGrtavfiaasasvkdal................tesvvd.vfavvkimreqrmmavqtldqyklvhelv

0036282 (Phosphotyrosine protein) phosphatases II 76-324 2.9e-36 120.1 In-house 1-165 (174) alignment
Range on Protein: 76-324
Range on HMM: 1-165/174.0
GNDYINASYVKVNVPGQsiepgYYIATQGPTRktwdqFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQYWPRggvddtvriaskwespggandmtqfps
|.||||||......        ..||.|||..     ||.|....   .  ..||.....| ...||..|||.                           
gsdyinaspldlsyitp.....rliagqgpla.....fwemlkel...gittvvmlleekelglykcinywpe...........................

dlkiefvnvhkvkdyytvtdikltptdPLVGPVKTVHHFYFDLWKDMNKPEEVVpIMELCAHSHSLNSR--GNPIIVHCSAGVGRTGTFIALDHLMHDTL
                               ..........  | |.. |.  . . |..   ..  |.  |.|..||||||||||||..|.. ...  |
...........................lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll

-DFKNItersrhsdrateeytrdliEQIVLQLRSQRMKMVQTKDQFLFIYHA
 .. ..                    ..| .||.||..|||| .|. |.|  
eslvda...................ldlvrelRlqrpgmvqtpsQyrflyyf

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 49-325 1.6e-34 114.4 In-house 47-280 (297) alignment
Range on Protein: 49-325
Range on HMM: 47-280/297.0
EPR-NDARNRYVNIMPYERNRVHLKTLSGN---DYINASYVKVNVPgqsiepgYYIATQGPTRKTWDQFWQMCYHNCPldnIVIVMVTPLVEYNReKCYQ
| . |  ..|| ||.||...||.|. .  .   ||.|||.||.|          .|.|| | . | . ||.| ... .    .|||.. . | .. || .
ekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh.......rlittqmPmkatvadfWamvldeqv...stivmlnddnerdk.kcar

YWPRGGVDDtvriaskwespggandmtqFpSDLKIEFVNVHKVKDYYTvTDIKLTPTDPLVGpvKTVHHFYFDLWKDMNKPE-----EVVPIMELCAHSH
||.  ||                     |  |. ..   |.. . .    ....|  .. .   . |. . |  | | . ..      .. ...   ...
yWsdkgvtt...................f.GdvsvvllsvsereGfik.relevtkgkakar..rvvkqyqfveWPdkaverkdsassllklisevrkdf

SLNSRGnPIIVHCSAGVGRTGTFIALDHLMHDTLDFKNItersrhsDrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHAA
| |. | |..|||.||||||| ....|  . .  . |..       |          | ..| .|| .|...||||.|. |.| | 
sqnaeg.PllvhclaGvGrtgvlltidsvvaeakrekev.......d..........ifglvkklrqerpylvqtkeqykfvyvav

PTPc_DSPc_SM00012 210-326 3.6e-34 112.5 In-house 1-104 (105) alignment
Range on Protein: 210-326
Range on HMM: 1-104/105.0
TVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLNSR---GNPIIVHCSAGVGRTGTFIALDHLMHDTLDFKnitersrhsdrateeyTRDLIEQIVLQLRS
||.|...  |.|...|||. .|.||... .. ..    ..|..|||||||||||||.||| |...  . .                ... |.||| .||.
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket................kevdifqivkelrk

QRMKMVQTKDQFLFIYHAAK
||..||||..|.||.|.| .
qRpgmvqteeqylflyrall

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 44-324 4.2e-34 113.1 In-house 40-283 (325) alignment
Range on Protein: 44-324
Range on HMM: 40-283/325.0
LGVSIEPRNDARNRYVNIMPYERNRVHLKTLSG---NDYINASYVKvnvpgQSIEPGYYIATQGPTRKTWDQFWQMC-YHNCPldnivIVMVTPLVEYNR
  |.  | | |.||. |.......|| |.|.      |||||||..     . ..   ..|.| |  .| . .|..    .|.     .|.|.  .. . 
kkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylr.....ddkkkdvflaaqaPltatindlWrlvldWrcs.....vvvvlneldlgk

EKCYQYWPRggvddtvRIaskwespGganDMTQFpSDLKIEFVNVHKVKDYY-TVTDIKltptDPLVGPVKTVHHFYFDLWKDM---NKPEEVVPIMELC
..| .|||.       ..       |   .  .|   |..... . .. ||   | |.|    ..  |  ..|. | .  |.||   ..|  ...|..| 
drcavywpk.......em.......g...ksktf.Gglevklrtieeisdyvhrvldvk....qvkkGetrsvkqfqlqswddmGvqkrpatlisilqlv

AHSHSL---NSRG-NPIIVHCSAGVGRTGTFIALDHLMHdtldfKNITErSRHsDrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHA
 . .     |...  ||.|||||||||||.||.|  ..      | |.| ||  |          | . | .|| .| .||.| ||. .||.|
kavservtantkastpilvhcsaGvGrtGvfislysala.....kviee.srv.d..........ifgfvkklrkdrpsmvetvdqyiliyea

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 46-325 5.4e-34 112.2 In-house 37-272 (515) alignment
Range on Protein: 46-325
Range on HMM: 37-272/515.0
VSIEPRNDARNRYVNIMPYERNRVHLKTLS---GNDYINASYVKvnvpgqSIEP-GYYIATQGPTRKTWDQFWQMCYHNCPldnIVIVMVTPLVEYNREK
|. |  |  .||| ||.||...|| |. .     .||.||||..      |..    |||.||| . . | ||.. ... .     |.||| | | .. |
vaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyip......sfdndkayiasqgPnkasvddfWrlvlqenv...ttiamvtklkegdkik

CYQYWPrggvddtvriaskwESPGganDMTQFPsDLKIEFVNVHKVKDYyTVTDIKLTPTDPlvgpVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSL
| .|||              . ||   |  .|   .|.| | ..   .  .   ....  |     ..||  | |  | |   |..   .. |     . 
cgkyWP..............dkpg...dsvkfG.sikvelvsleactgg.ikrkltvlkgdd....srtvtqfhfteWPdkGvpkhtssllklikevkad

-NSRGNPIIVHCSAGVGRTGTFIALDHLMHDTldfknitERSRHSDrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHAA
 .    |.|.|||||||||| .|..|  . .        . .|  |          . ..| ..| .|...|||..|. ||| | 
hgqythpliihcsaGvGrtGvvisidsvvaha.......kttrmvd..........vfnfvtnirqkrpylvqtqeqyafiygav

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 46-325 9.5e-34 111.6 In-house 38-273 (315) alignment
Range on Protein: 46-325
Range on HMM: 38-273/315.0
VSIEPRNDARNRYVNIMPYERNRVHL---KTLSGNDYINASYVKvnvpgqSIEP-GYYIATQGPTRKTWDQFWQMCYHNCPldnIVIVMVTPLVEYNREK
|. |. |  .||| ||.|....|| |        .|||||||.|      |..    |||.||| . . | ||.| ... .     ||||| . | .. |
varetinfkknryknilPldsarvkleviddsPdsdyinasyik......svdddkayiasqgPlkasvddfwrmvlqekv...ttivmvtkkqegdkik

CYQYWPRggvddtvRiasKwespggaNDMTQFPSdLKIEFVNVHKVKDYYTvtdIKLTPTDplVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSL
| ||||        |   |        | ..| | .|.| ....   |  .    ||.  .      .||  | |  | |   ....  ...|     . 
crqywPd.......r...k.......adsvefGs.ikvellsleadtdgva...rklvtrk..seesrtvtqfqftewPdkGvdkqtssllklikevkad

-NSRGNPIIVHCSAGVGRTGTFIALDHLMHDtldfknItERSRHSDrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHAA
 ...  ...||||||||||| .|..|. . .      | .|.|  |          . ..| .||..|...|||.... ||| | 
ngkkefsllvhcsaGvGrtGvvisidevvaq......i.krtrsvd..........vfnfvknlrakrpylvqteeeyafiydav

subfamily_PTPN9_pd Subfamily PTPN9 48-324 1.7e-33 111.0 In-house 38-285 (297) alignment
Range on Protein: 48-324
Range on HMM: 38-285/297.0
IEPRNDARNRYVNIMPYERNRVHLKTLSGN---DYINASYVKvnvpGQSiEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQ
  . |  .||| ... |.. ||.|......   |||||..|     |   ..  .|||||| .|| . ||.| . .   . .||||.| .||  | || |
klranleknrytdvlcydetrvvlakvdedeasdyinanfvd....Gyk.qkkafiatqGplkktvsdfWrmvWeq...evlvivmttrvvergrlkcgq

YWPRGgvddtvriaskwespggANDMTQFpSDLKIEFVNVHKVKDYyTVTDIKLTPTDplVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCA--------
||| .                  .....| .||... |.|.. .|| .|. .... ..   .  ..| || |  | |   |..   ....          
yWple.................eessaef.gdlsvsnveveeeedy.kvrvleiknvk..teesrkvthfqflsWPdyGvPssaaslldvlekvrekqal

------HSHSLNSRGNPIIVHCSAGVGRTGTFIALDHLMhdtldfkniterSRHSDRATEEytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHA
      ...  . .| ||.||||||.|||||||.||  .            ||  . .| .     . . | .||.||  ..|| .|. | | |
avkelgdewkghpsgPPivvhcsaGiGrtGtfitldicl............srleevgtvd.....vvetvkllrtqrafsiqtpeqyefcyla

0046846 (Phosphotyrosine protein) phosphatases II 76-328 1.5e-32 108.2 In-house 11-172 (176) alignment
Range on Protein: 76-328
Range on HMM: 11-172/176.0
GNDYINASYVKVNvpgqsiepgYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQYWPR----GGvddtvriaskwespggandmt
. |||||...  .         ..||||||...|  .|..| ...   .  ..|..| .||..| ||..|||.    |                      
dldyinanlilgs.........rpiatqgplprtladflemlkel...gitavvnlteevelgrlkcpnywpeleklgi.....................

qfpsdlkiefvnvhkvkdyytvtdikltptdplvgpvktvhHFYFDLWKDMNKPEEvVPIMELCAHSHSLNSRGNPIIVHCSAGVGRTGTFIALDHLmhd
                                         ....  | |.. |.    ..||..  ..  ..|.|..||||||.|||||..|.. |   
.........................................qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaayll...

tldfknitersrhsdrateE--YTRDLiEQIVLQLRSQRM-KMVQTKDQFLFIYHAAKYL
                   |  .  .. |... ..|.||. ..||| .|  |.|.....|
...................elekglsv.eealalvreqRplgavqtpeQyrflyefelll

0043147 (Phosphotyrosine protein) phosphatases II 76-328 1.8e-31 104.6 In-house 4-160 (172) alignment
Range on Protein: 76-328
Range on HMM: 4-160/172.0
GNDYINASYVKVNVpgqsiEPGYYIATQGPTRKTWDQFWQMCYHNCPLDnivIVMVTPLveynrekcyqywprggvddtvriaskwespggandmtqfps
|.|||||||.....      |  .||||||.| |...||.|....       ||..|.|                                         
gsdyinasyldlyy.....ipdrfiatqgplrntladfwrmlkelgith...ivnltel.........................................

dlkiefvnvhkvkdyytvtdikltpTDPLVGPVKTVHHFYFDLWKDMNKPeEVVPIMELCAHSHS--LNSRGNPIIVHCSAGVGRTGTFIALDHLMhdtL
                         . .  . .... ....  | |.. |     ..|..   ..  ..|.|.|..||||||||||||..|.. ..   |
.........................lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml...l

DFknitersrhsdrateeytrdLIEQIVLQLRSQRMKMVQTKDQFLFIYHAAKYL
..                     .|..| ..|..|...||...|  |.|. .|.|
gl....................sleeavalvrekRpgavqnpsqyrflyyfekll

0049772 (Phosphotyrosine protein) phosphatases II 34-327 3.7e-31 104.4 In-house 28-278 (314) alignment
Range on Protein: 34-327
Range on HMM: 28-278/314.0
TNGTVNSRWSLGVSIEPRNDARNRYVNIMPYErNRVHLKTL--SGNDYINASYVKVNvpgqsiepGYYIATQGPTRKTWDQF----------WQMCYHNc
....| ..... |.  ..|  .||| .|.|.. |||.|..|  || ||||||||.            .||||||.  |.. |          |.|  .. 
rslsvlpeltilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf........lkfIatqgpleitvvdfreepvlyyngwrmvlrg.

PLDNIVIVM---------------------VTPLVEYNrekcyqywprggvddtvriaskwespggandmtQFPSDLKIEFVNvhkvkdyytvtdiklTP
 |. ..|||                      ..| ...                                  .|.   .|. .               . 
dlnvrdivmsrdevladelsrLdaAlgKtpllildgng.................................neptaadlellk...............ee

TDPLVGPVKTVHHFYFDLWKDmNKPEEVVPIMELCAHSHSLnSRGNPIIVHCSAGVGRTGTFIALDHLMHDTlDfknitersrhsdrateeytrDLIEQI
...   . ... ...   . | . .     . |.... ... ..|.|..|||.||.||||||.... ||.   .                      .|..
lydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkll.g....................vsleea

VLQLRSQRM-----KMVQTKDQFLFIYHAAKY
. ..|..|.      .... .|..||..| ..
ledvrlkRpinpnpgfieqleqyefilealle

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 48-324 2.8e-29 96.7 In-house 41-231 (392) alignment
Range on Protein: 48-324
Range on HMM: 41-231/392.0
IEPRNDARNRYVNIMPYERNRVHL---KTLSGNDYINASYVKvnvpGQSIEpGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNrekcyq
 .. |  .||| ||.||...||.|      . .||.||||..    .   |   |||.|||   . |.||.| ...   .   |.||| | | .      
qkeinlkknryknilpydsarvkleviddipdsdylnasyip....sfdne.kayiasqgpnaaslddfwrmvfqe...nvttiamvtklkegd......

ywprggvddtvriaskwespggandmtqfpsdlkiefvnvhkvkdyytvtdikltptdpLVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSH-SLNS
                                                               ..||  |.|  | | . |. .  ....    .    .
...........................................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGq

RGNPIIVHCSAGVGRTGTFIALDHLMHDTldfknitERSRHSDrateeytrdLIeQIVLQLRSQRMKMVQTKDQFLFIYHA
   |.|.||||||||||  |..| ..  .       ...|  |         .. ..| ..| .|  |||||.|. ||| |
ythpliihcsagvgrtgvvisidsvvaha.......kktrmvd.........vf.nfvtnirrkrpymvqtkeqyafiyga

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 51-323 5e-29 96.0 In-house 47-281 (305) alignment
Range on Protein: 51-323
Range on HMM: 47-281/305.0
RNDARNRYVNIMPYERNRVHLKTLSGNDYINASYVKVnvPGqsiEPGYYIATQGPTRKTWDQFWQMCYHNCpLDniVIVMVTPLVEYNREKCYQYWPRGG
..  .||| ..   ..|||.|..    .|| | ||    |    .|  .| || |  ||  .|| ||. .  ..   | |.  |.|   .||..|..   
qeagknrykdvgcldnnrvklegpwpheyihanyvst..pt...npkrfictqaplektcadfwymclqdk.ve..aifmlcnllekgakkcleyfaskd

vDDTVRIASKwespgGANDMTQFPSDLKIEFVNVHKVKdyytVTDIKLTPTDPLVGPVKTvHHFYFDLWKDMNKPEEVVPIMELCAHSHSlnSRGnPIIV
 .|.. .  |     |   . .| |  ...|..  | |    ||. .|.   |     |.  |...  | |   |   . |.|| ... .  |.| ||.|
.kdvlefeek.....gqkisvkfessvtlkfrkdakak....vtetvlviegpgekarkv.thyhwidwpdrgvpaadlailellekarp..skg.pivv

HCSAGVGRTGTFIALDHLMHDTLDFKNITErsrhsdraTeeytrdliEQIVLQLRSQRMKMVQTKDQFLFIYH
|||||.||||. . |...... |  . | .        |        ..|. ..| || . .|| .|.||.. 
hcsagigrtgsvvmleyildqllagqiied........t........dkilqkireqrnnsiqtdaqylfvhq

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 38-150 6.9e-29 95.8 In-house 33-140 (288) alignment
Range on Protein: 38-150
Range on HMM: 33-140/288.0
VNSRWSLGVSIEPRNDARNRYVNIMPYERNRVHLKT---LSGNDYINASYVKVNVPGQsiepgYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPL
...  |  .. ...|. .||| ||.||. .||.||     .|.|||||||....   .      |||||||  .| ..||.. | |   .   |||.| |
lektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkk.....kyiatqgPladtvndfWelvyen...ktstivmltel

VEYNREKCYQYWPRGG
|| ...|| .||| ..
veggktkCeeYWPdad

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 51-323 8.3e-29 95.5 In-house 40-271 (307) alignment
Range on Protein: 51-323
Range on HMM: 40-271/307.0
RNDARNRYVNIMPYERNRVHLKTLS-GNDYINASYVkvnvpGQSIEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQYWPRG
 |  .||| ..   ...|. .|.     ||| | |.     | .|.|  .|..|||  .|  .|| |.  .   .   ..|.  ..|  . || ||||  
antdknryqdvkcqdkgrivvkfdglasdyihanyl.....giaikpkkficaqgplentqysfwamaiqe...kvesvimlckvielakikceqywple

GVDDTVrIASKwespGgaNdmTQFPSDLKIEfvNVHKVKDYYTVTDIKLTPTdplvGPVKTVHHFYFDLWKDMNKPEEVVPIMELCahsHSLNSRGNPII
  .  |  ...    .  |  |   ..| ..  ..   .|.  ||..|.  .    .  .|..|. .. | |   |.  .  ..|    .. .   ||..
egqklv.fgea....p..n..tisvanlgak..klapdedlinvttlkvdwa....qksrtiqhlqwenwpdrgvpqinltainll...eavrydtnpvv

VHCSAGVGRTGTFIALDHLMHDTLDFKNITErsrhsdrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYH
|||||||||.|| .|.  ..   .. .|  .                ....| .|||||   .||. |.|... 
vhcsaGvGrsGtivaislvqdkmiaGinckd................mkklveelrsqrhyaiqteaqylylhr

0049260 (Phosphotyrosine protein) phosphatases II 97-328 1.3e-28 95.0 In-house 9-149 (152) alignment
Range on Protein: 97-328
Range on HMM: 9-149/152.0
GYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQYWprggvddtvriaskwespggandmtqfpsdlkiefvnvhkvkdyytvtdi
 ..||||||.. |...||.| ...   .  .|||.| |.| ...||.||.                                                  
fefiatqgpgpntladfwrmlkel...gittivmltellelgklkceqyi..................................................

kltptdplvgpvktvhHFYFDLWKDMNKPEEVVPIMELCAHSHS-LNSRGNPIIVHCSAGVGRTGTFIALDHLMhdtldfKNitersrhsdrateeytrD
                ....  | |.. |.    ...|.   .  . ..|.|..||||||||||||..|.. ..      ..                  
................qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lg.................v

LIEQIVLQLRSQRMKMVQTKDQFLFIYHAAKYL
 .|..| ..|..|...|....|  |.|  .|.|
sleeavalvrekRpgavpnpgqlrflyefekll

0044763 (Phosphotyrosine protein) phosphatases II 63-331 2.2e-27 91.2 In-house 1-173 (178) alignment
Range on Protein: 63-331
Range on HMM: 1-173/178.0
PYERNRVHLKTLSG---NDYINASYVKvnvpgqsiePGYYIATQGPtRKTWDQFWQMCYHncpldniVIVMVTPLVEYNREKCYQYWPRGGVddtvrias
|..|.||.| .|.|    ||||||..          ||.|.....|  . .......  .       .||..|. .|....||..|||..          
pldrtrvllsnleglersdyinaseil.........pglylgslpp.addlellkelgit.......hivnlteelelgflkcdpywpeeag........

kwespggandmtqfpsdlkiefvnvhkvkdyytvtdikltptdplvgpvktVHHFYFdLWKDMNKPEEVVPIMELCAHSHSLN-SRGNPIIVHCSAGVGR
                                                   ......  . |.. |.    ..|...  ...  ..|.|..|||||||||
...................................................iqylhi.pipDhgvpdllehflefvefieealdekggpvlVHCsaGvgR

TGTFIALDHLMHDTLDFKNitersrhsdrateeytrdlieqIVLQLRSQRMkMVQTKDQFLFIYHAAKYLNSL
.||..|.. ...  |.. .                      .. ..|..|. .|.. .|  ..|  ...|.. 
sgtlvaaylmkklglslee......................aielvrerRp.ivpnpgqlrqLyefelrllke

subfamily_ptpA1_pd Subfamily ptpA1 50-274 4.3e-27 89.9 In-house 45-257 (418) alignment
Range on Protein: 50-274
Range on HMM: 45-257/418.0
PRNDARNRYVNIMPYERNRVHLKTL---SGNDYINASYVKVNVPGQsiepgyYIATQGPTRKTWDQFWQMCYHNCPldnIVIVMVTPLVEYNREKCYQYW
 .| ..||| ||.| .. ||.|| .    |.||||| |.    | |      .|.||||  .|  .||.| . |      .|||..   |  | || .||
khntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkq......fictqgplpntiadfwrmvwenrc...riivmlsresencrikcdryw

PRGGVDDTVRIAskwespGGANDMTqfpSDLKIEFVNVHKVKDYYTVT-DIKLTptdpLVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCaHSH------
|     . . |       |  |..        .|.|.| .  .   .| .|.||    . |  . . .. .. | | | |.   |. .|  ||       
peqiggeqfsiy......gngnevf...gtysvelveviqdpereiitrnirlt....fegetrditqyqyegwpdhnipdhtqpfrqll.hsitnrqnq

--SLNSRGNPIIVHCSAGVGRTGTFIALDHLMhDTLD
    . |  |||||||||||||||| .   .|   ||
iipssdrnvpiivhcsagvgrtgtfctavimm.kkld

0051082 (Phosphotyrosine protein) phosphatases II 77-324 8.8e-27 89.0 In-house 3-148 (151) alignment
Range on Protein: 77-324
Range on HMM: 3-148/151.0
NDYINASYVKvnvpgqsiepGYYIATQGPTRktwdQFWQMCYHncpLDNIVIVMVTPLVEYNreKCYQYWPRGGvddtvriaskwespggandmtqfpsd
.||||.|||           |......||.     .|... ..   |.  .||......|..  .|..|.|. |                          
sdyinfsyvt..........gglyrsggpla....dflellke...lgiktivnlrseeerg..ycpeylpelg..........................

lkiefvnvhkvkdyytvtdikltptdplvgpvKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSlnSRGNPIIVHCSAGVGRTGTFIALDHLMHDtldfk
                                 .|.|.... |.| . |.    ..|.  .  .   ...|..||||||.|||||..||. ....     
................................ievlhipildwpdpglplsfdavleflellld..kkngpvlvHCsaGkgRTGtlvalylmllg.....

nitersrhsdrateeytrDLIEQIVLQLRSQRMKMVQTKDQFLFIYHA
                    .|... ..|..|. .||...||||...|
..................vsleealeeyrlkrpgvvqpnqqflfqlfa

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 52-323 2.7e-26 87.2 In-house 35-264 (285) alignment
Range on Protein: 52-323
Range on HMM: 35-264/285.0
NDARNRYVNIMPYERNRVHLKTLsGNDYINASYVKVNVPGQSiepgYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQYWPRGgV
|   ||| ..   |  || ||     ||| ||....    ||     ||.||||  .|  .||.| |..       ..|.  |.|   |||  |.|   .
npdlnryadvrcieetrvvlknh.drdyihaswmrmpgkdqs....tyittqgplpetlsdfwhmiyqe...kiayvlmlctlfeggvekcalyypek.l

DDTVRIaSKWEspggandMTQfpSDLKIEFVNvHKVKDYYTVTDIKLTPTDPLVgpvktVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLNSRGNPIIVH
 . |..  |.|       .|   .. | | .    . .  ||.. . . ..||      . |     | |   ||.  |..||    . .| . .|| ||
gevvkf.gkye.......itl..teckeeaia.gtilnaltvintedasseply.....mnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvh

CSAGVGRTGTFIALDHLMHDTLDFKNItersrhsdratEeytrdLIeQIVLQLRSQRMKMVQTKDQFLFIYH
|||||||| ||. .|.     ..  ||           |     .. .|| ..|. |.. ||.. ||||.| 
csagvgrtatfvgidyatirimenpni...........e.....ml.divremramrfqavqshmqflflyv

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 46-151 1.4e-25 85.0 In-house 40-140 (318) alignment
Range on Protein: 46-151
Range on HMM: 40-140/318.0
VSIEPRNDARNRYVNIMPYERNRVHLKTLS---GNDYINASYVKvnvpGQSiEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKC
 |.|| | |.|||.||..|.. ||.|..|.   | |||||.|.     |   .   |||.|.|  .| . ||.| .     .  ||||.| ..|  ..|.
kslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyid....Gyr.rkkayiaaqaPlpetieDfWrmvWeq...nsavivmltqeeergkakv

YQYWPRGGV
 .|||  | 
hryWPskgs

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 45-323 5e-25 83.0 In-house 26-253 (267) alignment
Range on Protein: 45-323
Range on HMM: 26-253/267.0
GVSIEPRNDARNRYVNIMPYERNRVHLKTlSGNDYINASYVKVNVPGQsiepgYYIATQGPTRKTWDQFWQMCY-HNCPldniVIVMVTPLVEynrEKCY
  ||   |..|||. . .||. .|| |.| . ..|||||||.    ..      .|.||.| ..|  .|...   ...|    |||..|.  .   ..  
sqsiaeknqernrlddnlpyddtrvilrt.keeeyinasyvegyktkn.....afivtqdplkntitdfltvihdqkvp....vivlltkvft...dnir

QYWPRggvddTVRIASKWEspggandmtqfpsDLKIEFVNVHKVKDYYTVTdIKLTPTDPlvgPVKTVHHFYFDLWK-DMNKPEEVVPIMELCAHShSLN
..||       .  | |..             || .|.   .. .||  .| ..|   .      . |  .|.  |. . |.   . |.. . |.   |.
lfwPP.....kmgqakkyq.............dltvehslekeendyqiit.lelkfkne...sahnvtlyyykkwnintnnkpylkplfgilakn.qle

SRGNPIIVHCSAGVGRTGTFIALDHLMhdtldfknitersrhsDRATEEYTRDlIEQIVLQLRSQRMKMVQTKDQFLFIYH
  ..|..|.||.||||.|||. .|  .                .|| .| . | | . ....||||. .|.||.....|..
ngnrPlvvacsdGvGrsGtflvidsql................eraktegvsd.ifdflrkirsqriglvdtkeryiyihe

subfamily_CG7180_pd Subfamily CG7180 51-323 8.6e-25 82.0 In-house 41-284 (296) alignment
Range on Protein: 51-323
Range on HMM: 41-284/296.0
RNDARNRYVNIMPYERNRVHLKTLSGN---DYINASYVKvnvpgQSIEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNReKCYQYWP
 |  .||.|...||. ||| |..| |.   |||||.||        . .  || |..|...| |.||.. | .   .   .|..|   .... .. .|||
enreknrdvkvvPyDynRvvLekldGeeksdYinavyvd.....sflkkkeyivteapkketvdefWrlvyde...eisavvvLtktfdfak.mypsywp

RGGVDDTVRIASKWespggaNDMTQFpSDLKIEFVNVHKVkdyytVTDIKlTPTDPLVGPVKTVHHFYFDLWKD-MNKPEEVVPIMELCAHSHSLNSRG-
  .  .   |  .         . |. ..|||  . . |      .  .    . . . ....|..| .  |.   . |     ..||    ...  .  
nkskeqygeifvei......veekqy.anlkirtfkltkk.....ivalt.eqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvd

-----NPIIVHCSAGVGRTGTFIALDHlmhdtldfkNItersrhsDRATEEYTRDLIeQIVLQLRSQRMKMVQTKDQFLFIYH
     .|..|..| |..|.| ..|.|          |.       . . .|   |.  . | .|| .| ..|...... .|| 
edpeegPvvvvssdGasRsGvylaida.........nl.......elvekeeevdvF.eavktlrrsRpqLvenveeYkyiYd

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 176-325 1.1e-24 82.1 In-house 145-276 (318) alignment
Range on Protein: 176-325
Range on HMM: 145-276/318.0
DLKIEFVNVHKVkDYYTVTDIKLTPTDplVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLN--SRGNPIIVHCSAGVGRTGTFIALDHLMhdtl
.|..|  .  .. ..|..  .|.| |.  .  ...|. . .  | | . ||... ...|  .... .  |  .||.|||||||||||.|||.| |.    
klvvelkeevel.sdyvlrefkvtrte..eeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdill....

dfknitersrhsDRATEEYTRDLIeQIVLQLRSQRMKMVQTKDQFLFIYHAA
            .|. .| . |.  |.| |||.||  ||||.||. |||.. 
............erikaealvDvf.qtvkqlreqrnlmvqtedqyefiydvl

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 46-149 2.8e-24 80.5 In-house 25-125 (297) alignment
Range on Protein: 46-149
Range on HMM: 25-125/297.0
VSIEPRNDA--RNRYVNIMPYERNRVHLK-TLSGNDYINASYVKVnvPGQSiEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKC
 |   || .  .||| .|. .. .||.|. . ...||||| ||    | .  .. .|| .|||...| |.||.. ...   |  |||||. | |  |.||
fssakrnsslrknryrdilatddtrvkllrviterdyinadyvvf..pdee.adlkyilaqGplsatvddfwtlvaeq...dvrvivmvaklqedGrdkc

YQYWPRG
. |||. 
apywpsv

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 51-148 2.1e-23 77.8 In-house 2-93 (237) alignment
Range on Protein: 51-148
Range on HMM: 2-93/237.0
RNDARNRYVNIMPYERNRVHLKTL-SGNDYINASYVKvnvpGQSIEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQYWPR
.| ..||| ||. |. .|| ||   || |||||.|.|    |    |  |||.|||   . |.|||| . .      ||||.| |.| |..||..||| 
enkiknrygnivaydhsrvvlkgagsgsdyinatylk....gfdgtpkkyiaaqgplesscddfwqmvwqe...kcsvivmltgliegnelkchkywps

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 207-324 8.3e-23 75.8 In-house 173-274 (288) alignment
Range on Protein: 207-324
Range on HMM: 173-274/288.0
PVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLNSRG-NPIIVHCSAGVGRTGTFIALDHLMHDTLDfknitersrhsdrateEYTRDLIeQIVLQLR
   ..... .  | |.. ||   |..||    .  |.   .|||||||||||||||||||| |..                    | . |..  .| .||
teleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidavee................edyiDva.gtvaklR

SQRMKMVQTKDQFLFIYHA
 ||. .|||. |. |||..
kqRallvqtlkqYefiyev

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 52-323 1e-22 75.2 In-house 55-283 (305) alignment
Range on Protein: 52-323
Range on HMM: 55-283/305.0
NDARNRYVNIMPYERNRVHLKTLSGNDYINASYVKVNVpgqsIEPGYYIATQGPTRKTWDQFWQMCYHNCpLDNivIVMVTPLVEYNREKCYQYWPRG-G
. ..||| ..   ... |.|.  |  ||| | || . .    |    .|..|||  .| |.|| |  .|  ...  |||.   ||  . || ||||   |
aitknryqdvpcqdqsavkldkpspsdyihanyvgcpm....ipekrficaqgpldqtidefwwmviqnk.veq..ivmlcktvelgklkcaqywpaaqg

VDDTVRIASKWESPGGANDMTQFPsDLKIEFVNVHkvkdyYTvTDIKLtptdplvgpvkTVHHFYFDLWKDMNKPEEVVPIMELCAhshSLNSRGNPIIV
   ...     |   |.. | . . ...|  .|.      |.  | |.           .| |. .  | |   |   .  .|| .   ..     ||.|
eklelksgivvenvsgskpmerda.eiqitllnlt.....ys.gdqkm...........svrhlqwtewpdrgvppckltslells...airgskvpivv

HCSAGVGRTGTFIALDHLMHdtldfkNITERSRHSDrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYH
|||||.||||| .|.....       .|.|  .             . ..|  || ||   .|.  |.|||. 
hcsagigrtgtivaieyile......kiaenkpcpp..........mpelvkalrdqrafsiqndvqylfihr

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 44-149 1.5e-22 75.0 In-house 39-135 (287) alignment
Range on Protein: 44-149
Range on HMM: 39-135/287.0
LGVSIEPRNDARNRYVNIMPYERNRVHLKTlSGNDYINASYVKvnvpGQSiEPGYYIATQGPTRKTWDQFWQMCYHNCPldnIVIVMVTPLVEYNREKCY
. ..| ..|  .||. .|.... .|| ||    .|||||....    | . |   .|....|  .|  .||..  .. .    .|||.. . | ..|.||
vthniasqnkdknRltqilvpdnyrvllkg.ehpdyinavfid....gyk.ekkafiiaesPmfntarnfWkliddrnv...taivmlcqekendeevcy

QYWPRG
|||| .
qyWpee

0048076 (Phosphotyrosine protein) phosphatases II 194-328 4.8e-21 70.4 In-house 34-142 (145) alignment
Range on Protein: 194-328
Range on HMM: 34-142/145.0
TDIkltpTDPLVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLNSRGNPIIVHCSAGVGRTGTFIALDHLMHdtldfknitersrhsdrateeYT
 ..    |. | ...... ....  | |.. |.    ..|...  ... ..|.|..||||||||||||..|.. ...                     . 
lnl....tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....................lg

RDlIEQIVLQLRSQRMKMVQTKDQFLFIYHAAKYL
 . .|... ..||||...|.. .|. |.| . ..|
vs.leealelvrsqrpgavpnpgqlrflyefelel

0048179 (Phosphotyrosine protein) phosphatases II 187-327 6.8e-21 69.9 In-house 25-143 (144) alignment
Range on Protein: 187-327
Range on HMM: 25-143/144.0
VKDYYTVTDIKLTPTDPLVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLNSRGNPIIVHCSAGVGRTGTFIALDHLMhdtldfknitersrhsd
 |..   | | ||.. .   . ........  | |.. |.    . |...  ... ..|.|..||||||||||||..|.. ..                 
lkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk.................

rateEYTRDlIEQIVLQLRSQRMKMVQTKDQFLFIYHAAKY
    ..  . .|... ..||.|. .|.. .|. |..   |.
....klgls.leealalvrsrrpgavpnpgqlrfLleyekl

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 52-326 1.5e-20 68.4 In-house 43-268 (288) alignment
Range on Protein: 52-326
Range on HMM: 43-268/288.0
NDARNRYVNIMPYERNRVHLKtlsgnDYiNASYVKVNVPGQSIEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQYWPRGgV
| .|.|| |.   .  ||.|.     |     |...||   .  .   | .| | . | ...|.|  ..   |   |||.. |.|  .||  .|.|   .
nptrdryenlprcditrvkls.....dd.pdfyiaanvvssakykrrlicaqaPlngtieelWkmlles...dveyivmlcellekGkeksaeyfPsk.l

DDTVRIASKwespggandmtqfPSDLKIEFVNVHKVKDYYTVTDIKLTPTDPlvgpvkTVHHFYFDLWKDMNKPEEVVPIMELCAHShslNSRGNPIIVH
 ...||                 .. | . ....|.    ..   | . .         | . ..  |.|   ||. .. . |.      .|  .||.||
Gekarigrl.............ctvvkkkradidklvkvsllriskegeekv......ivkilhlleWdddgvPenylsplrllevl...kslqkPivvh

CSAGVGRTGTFIaLDhLMhdtldfknITERSRHSDRATeeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHAAK
.|||||||||.| |  |.        . |  | .|  .       |.... .|| .|.| .||. |.|...   .
ssaGvGrtgtli.li.li........aleslrlddflg.......irsllaklreerfkaiqtemqylyvhrcvl

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 52-148 1.5e-19 65.1 In-house 8-100 (239) alignment
Range on Protein: 52-148
Range on HMM: 8-100/239.0
NDARNRYVNIMPYERNRVHLKTLSG---NDYINASYVKVNvPGqsiEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQYWPR
| |.||| ||. |...|| |. ||    .|||||||..    |    |  ||||||    .  .||.| ...      ||||.| |.|  ..||.|||| 
nkaknryanivtydhsrvvleklsndphsdyinasylrdy.dg...spkayiatqgcveissgdfwrmmwqe...rrcvivmltglieghkkkchqywpd





subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 52-148 1.6e-19 65.0 In-house 7-99 (239) alignment
Range on Protein: 52-148
Range on HMM: 7-99/239.0
NDARNRYVNIMPYERNRVHLKTLSG---NDYINASYVKVNvPGqsiEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQYWPR
| |.||| ||. |...|| |. ||    .|||||||..    |    |  ||||||    .  .||.| ...      ||||.| |.|  ..||.|||| 
nkaknryanivtydhsrvvleklsndphsdyinasylrdy.dg...spkayiatqgcveissgdfwrmmwqe...rrcvivmltglieghkkkchqywpd





subfamily_PTPRN_pd Subfamily PTPRN 48-151 3.5e-19 63.6 In-house 52-151 (297) alignment
Range on Protein: 48-151
Range on HMM: 52-151/297.0
IEPRNDARNRYVNIMPYERNRVHLKTL---SGNDYINASYVKVNVPGQSIepgyYIATQGPTRKTWDQFWQMCYHNCpldNIVIVMVTPLVEYNREKCYQ
 ...|  .||. ...||. .||.||.    . .|||||| .  . | ...    |||||||  .|  .|||| ...     .|||..|.| | . ..|..
kaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapa....yiatqgplastvadfwqmvweqG...vvvivnltrleeegvkqckr

YWPRGGV
|||  | 
ywpdeGs

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 51-148 1.8e-18 61.3 In-house 37-128 (287) alignment
Range on Protein: 51-148
Range on HMM: 37-128/287.0
RNDARNRYVNIMPYERNRVHLK--TLSGNDYINASYVkvnvPGQSIEpGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQYWPR
 .  .||| ...|.. .|| |   .  | ||||| ||    ..   .   .||.|||   |  .||.. ...      .....|  ||  | |||.||| 
aavkknryadvlPiddtrvllsaegelGsdyinanyv....asytdd.eafiaaqgPiaatvrdfwravlet...rsasvitmtreveearlkcykywPe





subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 51-322 2.3e-18 60.8 In-house 51-283 (310) alignment
Range on Protein: 51-322
Range on HMM: 51-283/310.0
RNDARNRYVNIMPYERNRVHLKTL--SGNDYINASYVKVNVPGQSiepgyYIATQGPTRKTWDQFWQMCYHNCpldNIVIVMVTPLVEYNREKCYQYWPR
..  .||| ...  .  ||.||      .||| | ||| |   ..     .| .||| ..|  .||.| . .       |...   .|  | ||  ||| 
kymhknrysdvvcldtsrvklkidksryedyihanyvktnylrst.....ficsqgplqhtiidfwrmifqer...aesilllckvgeegrpkcvgywps

GGVDDTVRIASkwespggANDMTQFPSDLKIEFVNVHKVKDYYTVTDiklTPTDplvGPVKTVHHFYFDLWKDMNKPEEVVPIMelcAHSHSLNSRGNPI
 || .|              ....   ...|  . |  | |   | .    |..        |    .  | |.  |.| .  .         . |  | 
lgvtetygcir.......vtnlsesseefeicnlavtfvpdnvpvde...qpan...lkelrvslikwpnwpdrgvpdekchtv...pqrllaqvrhgpc

IVHCSAGVGRTGTFIaldhlmhdTLDFKniTERSRHSDRATeeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIY
.||||||..|... .        .|..|   ..... ..         .|... .|. .|.. .||. |.|.| 
vvhcsagkdrlyvvv........alklk..idkldrglkvd.......aeevktellksraiciqtelqyliid

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 94-320 2.9e-18 60.6 In-house 87-272 (301) alignment
Range on Protein: 94-320
Range on HMM: 87-272/301.0
IEPGYYIATQGPTRKTWDQFWQMCYHNcPLDNivIVMVTPLVEYNREKCYQYWPRGGVddtvriaskwespggaN--DMTQFpsDLKIEFVNVhKVKDYY
 .|  .|||||| ..| . || |. .   ...  |||..  ||.. ||| .| |                    .  |. .|  ..||.  ..  ...  
GhphrfiatqgPlkntsedfwamlvqy.dvek..ivmlgqkvekleekceeylpvkis................ekldigrf..kikiknkel.ilnkki

TVTDIKLTPTDPLVgPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHshsLNSRGNPIIVHCSAGVGRTGTFIALDHLMHDTLdfknitersrhSDRATEe
.   .... .   . . .|| |. .  | | . |.  . ...|      .    .||.||||||.||. .||. . | .. .           .|.  | 
skrtlevedstgkf.atrtvthyqysewtdrgvPkshaelfdlmel...vkksekPivvhcsaGiGrsvafigteylareve...........adptie.

ytrdlIEQIVLQLRSQRMKMVQTKDQFLF
     . . . .|| .| . |||. |. .
.....ltealkhlrehrwngvqtnsqlyw

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 44-148 4.1e-18 60.4 In-house 41-140 (315) alignment
Range on Protein: 44-148
Range on HMM: 41-140/315.0
LGVSIEPRNDARNRYVNIMPYERNRVHL---KTLSGNDYINASYVkvnvPGQSiEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNRE
| |. .  |  .|||.||..|.. ||.|   .. .. ||.||...    .| .  .  |||.|||   . . ||.. ...   |   |||.| ||| ...
ldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfi....dGyn.kkrryiaaqgpnvasvkdfwrlvfee...digkivmltnlvegekr

KCYQYWPR
|. .||| 
kaekywpd

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 207-324 1.1e-17 58.9 In-house 173-274 (315) alignment
Range on Protein: 207-324
Range on HMM: 173-274/315.0
PVKTVHHFYFDLWKDMNKPEEVVPIMELCA--HSHSLNSRgNPIIVHCSAGVGRTGTFIALDHLMhdtldfknitersrhsDRATEEYTRDLIeQIVLQL
 ...|  . .  | ||. |.  .|.|.|    . |  ||   .|.||||||||||||||.|| ..                |.|  |   |.  ... ..
nirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavl................dqaeaenaidvy.nfitgv

RSQRMKMVQTKDQFLFIYHA
|..|.||||. .|. ||| |
rqnrikmvqvaeqyqfiyda

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 55-269 1.8e-17 58.0 In-house 46-233 (312) alignment
Range on Protein: 55-269
Range on HMM: 46-233/312.0
RNRYVNIMPYERNRVHLKTlSGNDYINASYVKVnvpgqSIEPGYYIATQGPTRKTWDQFWQMCYHncpLDNIVIVMVTPLVEYNREKCYQYwprggVDDT
 ||| ||  ..| |  |     | || | .||.        |  ...||||  .|  .|||..     | .  |.... .||   ||| .|     . | 
lnrypniqcwdrgrftlag.denfyihanfvki.....ctkperfvctqgplentcthfwqlals...lgstsiillcgfvedgsekcaky.....isdi

VRIASKWEspggANDMTQFPSDLKIEfvnvHKVKDYYTVTDIKLTPTdpLVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAhshSLNSRGNPIIVHCSA
| .    .        |.. ....|      | ||  |   .|.       |    . |. .  | |   |. .   . | .   ...   .|.| ||||
vgfvdled....hrvyteycteieig....gkskdkithrvlkvvvk..atgqesklnhyqwaswpdhgmpdscdtalrlls...avkkdkkpviahcsa

GVGRTGTFIALDHLM
|||||||.. .. ..
gvgrtgtlaliesmi

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 45-152 3.1e-17 57.2 In-house 33-137 (301) alignment
Range on Protein: 45-152
Range on HMM: 33-137/301.0
GVSIEPRNDARNRYVNIMPYERNRVHLKTLSG-----NDYINASYVKvnvpgQSIEPGYYIATQGPTRKTWDQFWQMCYHNCPldnIVIVMVTPLVEYNR
 |... .| | ||. || .|. ||. ||. .      ..||||||..        |   .||.||| .||  .||.. ... |   . ||||| | |  .
tvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyid.....gysekkkfiaaqgpmkktlvdfWrliwqekp...vsivmvtnlkegtk

EKCYQYWPRGGVD
.||.||||..  .
skceqywpnseae

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 233-325 1.6e-16 54.6 In-house 253-340 (349) alignment
Range on Protein: 233-325
Range on HMM: 253-340/349.0
ELCAHSHSLNSRGNPIIVHCSAGVGRTGTFIALDHLMHdtlDFKNITERSRHSDraTEEYTRDLIEQIVLQLRSQRMKMVQTKDQFLFIYHAA
.| |. .  ... ....|||||| ||||... || |.     ..  .. |   .   .  ..|||  || .|| ||. |||   || .||.| 
dlfarlyldtdqlstllvhcsaGcGrtGvlvtldllls...ileplqnesnkik..lqallkDlisiivnelrkqrismvqnlaqfiaiyeal

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 49-149 4e-16 53.5 In-house 34-130 (281) alignment
Range on Protein: 49-149
Range on HMM: 34-130/281.0
EPRNDARNRYVNIMPYERNRVHLKT----LSGNDYINASYVKVNVpgqsIEPGyYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQ
.| |. .|||.||   .  ||.||         ||| | |..  .    .. | || |||| ..|  .||.| ...   .   |||.  ..| ||||| .
qpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspf....lkrg.yiltqgpkketradfwrmiwqe...nttaivmlcqfletnrekcae

YWPRG
|.|| 
yfprn

subfamily_egg_pd Subfamily egg 43-325 6.7e-16 52.8 In-house 31-266 (307) alignment
Range on Protein: 43-325
Range on HMM: 31-266/307.0
SLGV--SIEPRNDARNRYVNIMpyERNRVHLKTLSG---NDYINASYVKvnvpGQSIEpGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEY
||    | . .. ||.. |.    .  ||.|.   |   .|.| | .||    |. .    .| .| | . | |.||.| . .   .   |||.|  .| 
slttaasdnnlekarskrvhck..dssrvklelrrGqylddfihanrvk....Gkpll.nefilaqaplkntvddfwrmvfqe...evqyivmltsrkes

nrEKCYQYWPRGGVDDTVRIaskwespggandmtqfPSDLKIEFVNVHKVKD-YYTVTDIKLtptdplVGPVktVHHFYFDLW-KDMNKPEEVVPIMELC
  |.|  |||.   |  | .                |  |.|| ..|..  |  ..|| .||      ||.       . . |  |.|.  .|   ... 
..erceyywpkaesdslvtv................pGslrienlkvdskadplfrvtklkl......vGgd..deerflehwqgdvnnssdvysplrvl

AHshsLNSRGNPIIVHCSAGVGRTGTFIALDHLMHDTLdfknitersrhsdRAteEYTRDLIEQIVLQLRSQRMKMVQTKDQFLFIYHAA
 .   |    .|..|..  || ...|..|..  . . |             |     |. |. . |  || .|   |..  ..||.|   
rk...lrnlskpvvvqdilGvskaatlvaieiallsll.............rG..pitkslvlravvflrlrrrlsvesvllylfvyrlv

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 207-324 1.9e-15 51.3 In-house 172-274 (439) alignment
Range on Protein: 207-324
Range on HMM: 172-274/439.0
PVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLNS--RGNPIIVHCSAGVGRTGTFIALDHLMHdTLDFKNitersrHSDrateeytrdlIEQIVLQL
  .|| .|..  | | | | .   ....     | |      |..|||||||||||| ||||  .   |  .|      . |          |. ||  |
kertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdiale.qlklen......kvd..........ikgivkvl

RSQRMKMVQTKDQFLFIYHA
| || .|||.  |..||| |
rkqrkqmvqalcqyvfiyna

subfamily_PTPRN_pd Subfamily PTPRN 207-324 2.1e-15 51.2 In-house 185-287 (297) alignment
Range on Protein: 207-324
Range on HMM: 185-287/297.0
PVKTVHHFYFDLWKDMNKPEEVVPIMELCAH-SHSLNSRGNPIIVHCSAGVGRTGTFIALDHLMHdtldfkNITERSRHSDrateeytrdlIEQIVLQLR
  .||  |.|  |.... | .  ...|.      |   |  ||.||||.|.||||..|..| ...      ...   .. |          |   .  ||
etrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvln......rllkGvkeid..........iaatlehlr

SQRMKMVQTKDQFLFIYHA
 || ..|.||||| |.. |
dqrpglvktkdqfefalta

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 176-329 2e-14 48.3 In-house 142-279 (287) alignment
Range on Protein: 176-329
Range on HMM: 142-279/287.0
DLKIEFVNVHkVKDYYTVTDIKLTPTDpLVGPVKTVHHFYFDLWKDMNK-PEEVVPIMELCAHSHSLNSRGN-PIIVHCSAGVGRTGTFIALDHlmhdTL
. .||..| . |.. |.. ..... ..   |. ..|. . .  |..  | .|    .. .    ..   ||| .|.||||..|||...|.| .     |.
eyniellnee.vnagyierklevknkn.kagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaat....ti

dfknitersrhsDRATEEYTRDLIeQIVLQLRSQRMKMVQTKDQFLFIYHAA-KYLN
            ... .| . |.. |.. . | |....||| .|. ||...  .||.
............nkckteGviDvf.qvlksqriqkpgsvqtveqykfindivleyld

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 53-148 8.8e-13 42.5 In-house 55-142 (290) alignment
Range on Protein: 53-148
Range on HMM: 55-142/290.0
D--ARNRYVNIMPYERNRVHLKTLSGNDYINASYVKvnvpGqsIEPgYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQYWPR
    .||| ...  .. || ||     ||. | |||    |  ...  .| |||....|  ..|.|  ..   .  .|||.  |.|  . || ||.| 
tefkknrykdvvcndktrvilkdGydGdyvhanyvk....G..lka.mfiltqGalkdtvidiwrmvlqe...kvaaivmlceliedGkakceqyype

subfamily_CG42327_pd Subfamily CG42327 50-239 3e-12 40.8 In-house 26-191 (319) alignment
Range on Protein: 50-239
Range on HMM: 26-191/319.0
PRNDARNRYVNIMPYERNRVHLKTLSGN---DYINASYVKvnvpGQSIEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQYW
.  . ..|..|..|    || |.  . .    |..||||.    |.   | .|||.| .  ..  .||.. . .      ||| .| | |   ..| .|.
vtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvr....Gyddapnsyiaaqvsledsssdfwrtvweq...qsrvivqltdlselGikvcaeyl

PrggvddtvriaskwesPGGANDMTQFPSDLKIEFvNVHKVKDYYTVTDIKLTPTDPLVgpVKTVHHFYFdLWKDMNKPEEVVPIMELCAHSH
|                .  . | |.   |... .    .||| | .. . |   |      . . |...  | . . | |  ... .  . .
P................tketldntslyGdilvtl.kgrevkdryaistlllkrvdkee..srelthywy.kwleaevPaeeaaliamllevr

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 52-149 3.6e-12 40.5 In-house 48-135 (439) alignment
Range on Protein: 52-149
Range on HMM: 48-135/439.0
NDARNRYVNIMPYERNRVHLKTLSG---NDYINASYVKvnvpGqSIEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNRekcyqYWPR
....||| .. ...  || |. . |     |||| |.|    |   ..  |||||||...| |.||.. ...     . |||.| |||  .     ||| 
dqtknrykdvgafdhtrvtlqeipgvphshyinanyik....G.yyddklyiatqgpkkettddfwrlviek...ktvtivmltnlvesyk.....ywps

G
 
d

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 98-267 5e-12 40.4 In-house 5-156 (198) alignment
Range on Protein: 98-267
Range on HMM: 5-156/198.0
YYIATQGPTRKTWDQFWQMCYHNCpldNIVIVMVTPLvEYNREKCY-QYWPRggvddTVRIASKWESpggandMTqfpsdlkIEfVNVHKVKDYYTVTDI
 ||||| | |.|  .|||| .         ||||    . |.|  |  |||      |   ..|. |      ..       .  ...  .|  ||.| .
ryiatqhplretladfwqmvwetg...sghivmvndd.qknkeadypfywpt.....tesgtgkygs......ls.......vt.tktittkpdytital

KLTPTDPLVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAhSHSL-----NSRGNPIIVHCSAGVGRTGTFIALDH
 ||         . . |. |  ||.   |.  . .  . | |  .     . .  |.||||| | | || |.||| 
iltnnttappstreishyqftswkekttpnvalfvgfvva.srevskkyeqekdapvivhcsdgqgftgvfvaldi

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 98-267 6.8e-12 40.0 In-house 6-157 (199) alignment
Range on Protein: 98-267
Range on HMM: 6-157/199.0
YYIATQGPTRKTWDQFWQMCYHNCpldNIVIVMVTPLvEYNREKCY-QYWPRggvddTVRIASKWESpggandMTqfpsdlkIEfVNVHKVKDYYTVTDI
 ||||| | |.|  .|||| .         ||||    . |.|  |  |||      |   ..|. |      ..       .  ...  .|  ||.| .
ryiatqhplretmadfwqmvwetg...sghivmvndd.qknkeadypfywpt.....tesgtgkygs......ls.......vt.tktittkpdytital

KLTPTDPLVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAhSHSL-----NSRGNPIIVHCSAGVGRTGTFIALDH
 ||         . . |. |  ||.   |.  . .  . | |  .     . .  |.||||| | | || |.||| 
iltnnttappstreishyqftswkekttpnvalfvgfvva.srevskkyeqekdapvivhcsdgqgftgvfvaldi

subfamily_CG42327_pd Subfamily CG42327 243-326 1.3e-11 38.7 In-house 245-312 (319) alignment
Range on Protein: 243-326
Range on HMM: 245-312/319.0
SRGNPIIVHCSAGVGRTGTFIALDHLMHDtLdfknitERSRHS-DrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHAAK
..  |..|||| ||||||. || |  ..  |      | |..| |          | |.| ..| .| . |.||.|. |||. . 
esqGPlvvhcsdGvGrtGlviasdiairs.l......eeskrsvd..........iPqlvssvrrdrasavltkeqyefiykvls

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 104-268 2.8e-11 37.4 In-house 98-244 (302) alignment
Range on Protein: 104-268
Range on HMM: 98-244/302.0
GPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQYWPRgGVDDTVRIASKwespggANDMTQFPSDLKiEFVNvhkvKDYYTVTDIKLTPTDP
 | ..| ...| .  .    .  ..| .. .|| . .|| .|.    |.....          .    .   ||. || .    |  ...  .... .  
vpkkstlekhwalieqy...nvaivvqlcsfvedeekkcaeyysd.kvggelkfgry......tvktvsvktdle.eftd....kksfklytveiknekk

LVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLNsrgNPIIVHCSAGVGRTGTFIALDHL
     |||. ..|  | |   |.|  . ...  .  |     . ..||||||||||||..|. . 
kkkvkktvdilafsawpdhGapkeaytaldilkfcesyk...knvlvhcsaGvGrtGtlvaikyG

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 53-162 1e-10 35.5 In-house 49-170 (349) alignment
Range on Protein: 53-162
Range on HMM: 49-170/349.0
DARNRYVNIMPYERNRVHLKTL-----------------SGNDYINASYVKVnvPGQSIEPgYYIATQGPTRKTWDQFWQMCYHNCpldNIVIVMVTPLV
 |.||| .|.|||  || ||                     .||||| |.|.  .  |.|   ||||| |   | | |...   |      ... ..   
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkl..trisvek.kyiatqaPlPstvddfykvillng...vklvlsLnddk

EYNREKCYQYWPRGGVDD-TVRIASKWE
| . |||..||  .  .. ||..   ..
elslekcdiywqelsysnitvklqnssl

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 191-323 1.3e-10 35.9 In-house 116-233 (237) alignment
Range on Protein: 191-323
Range on HMM: 116-233/237.0
YTVTDIKLTPTDPLVgPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHS--HS-LNSRGNPIIVHCSAGVGRTGTFIALDHLMHDTLDFKNItersrhsDr
|||  . |.    |   |. .| . |  | |   |..   .. .  .   .|   |.  | |.|||||||||| |. .| ..... . | .       | 
ytvrslllskrltlk.evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvv.......d.

ateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYH
         | . |  .  .|  ..|||||..||..
.........iynyvysieedrpyiiqtkdqyvfihq

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 210-324 1.8e-10 35.4 In-house 138-236 (239) alignment
Range on Protein: 210-324
Range on HMM: 138-236/239.0
TVHHFYFDLWKDMNKPEEVVPIMELCAHS--HSLNsRGNPIIVHCSAGVGRTGTFIALDHLMHDtldfknitersrhsdrATEEYTRDLIEqIVLQLRSQ
 |....| .| |   |.    .. |  .    ||     | ..||||||||||.|. .| ....                | .. | |...  |  .| .
yvyqyhftvwpdkgvpqyatavlglrrkitkdslp.garpwvihcsagvgrtgaflvidamlrq................akkqktvdifn.yvkaired

RMKMVQTKDQFLFIYHA
| .|||| .|..||. |
rphmvqtseqyvfihla

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 210-324 1.8e-10 35.4 In-house 137-235 (239) alignment
Range on Protein: 210-324
Range on HMM: 137-235/239.0
TVHHFYFDLWKDMNKPEEVVPIMELCAHS--HSLNsRGNPIIVHCSAGVGRTGTFIALDHLMHDtldfknitersrhsdrATEEYTRDLIEqIVLQLRSQ
 |....| .| |   |.    .. |  .    ||     | ..||||||||||.|. .| ....                | .. | |...  |  .| .
yvyqyhftvwpdkgvpqyatavlglrrkitkdslp.garpwvihcsagvgrtgaflvidamlrq................akkqktvdifn.yvkaired

RMKMVQTKDQFLFIYHA
| .|||| .|..||. |
rphmvqtseqyvfihla

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 206-278 5.9e-10 33.3 In-house 180-249 (290) alignment
Range on Protein: 206-278
Range on HMM: 180-249/290.0
GPVKTVHHFYFDLWKDMNKPEEVVPIMELcahSHSLNSRGNPIIVHCSAGVGRTGTFIALDHLMHDTLDFKNI
|  . ..|.    | |   .   . .. .    ..|     |..||||||.||||||.|..  .   || |..
Gkehklkhlkikswpdksvalstlallrt...lrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkel

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 243-325 2.3e-09 31.6 In-house 226-291 (297) alignment
Range on Protein: 243-325
Range on HMM: 226-291/297.0
SRGNPIIVHCSAGVGRTGTFIALDHLMhdtldfkNITERSRHSDRATeeytrdlieqIVLQLRSQRMKMVQTKDQFLFIYHAA
 |  ...|||||||||.|  .  | ..       ... . |  | |.          |. .||.|| ..||| .|| ..|.|.
prnayllvhcsaGvGrsGvvvlsdvil.......aklrkkripdvaa..........ilsilreqrarlvqtleqfellydav

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 209-325 2.7e-09 30.9 In-house 89-190 (440) alignment
Range on Protein: 209-325
Range on HMM: 89-190/440.0
KTVHHFYFDLWKDMNKPEEVVPIMELCAHS-HSLNSRGN-PIIVHCSAGVGRTGTFIALDHLMHDTldfknitersRHSDRAteeytrDlIEQIVLQLRS
.|....... | |   |. . |....     .| .  || |..||||||.||||  ||.| .....          ..||.       | |  ..  .|.
rtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilrea..........krsdqi......d.ifsfinsmrn

QRMKMVQTKDQFLFIYHAA
.| .|||| .|. |...| 
nrpqmvqtpeqyafvheav

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 206-323 6.1e-09 29.9 In-house 164-263 (281) alignment
Range on Protein: 206-323
Range on HMM: 164-263/281.0
GPVKTVHHFYFDLWKDMNKPEEVVPIMELCahsHSLNSRGNPIIVHCSAGVGRTGTFIALDhlmhdtldfknITERSRHSDrateeYTRDLIEQIVLQLR
|  . . |. .  | | . ||    ....    . . .|  | ..||||||||.||..|..           |. .| ||      .|   |.||| .||
getrlithwlwkewpdwqvpessevmlkil...rkirarstppvihcsagvgrsgtlmave...........ialqsihsh.....ftlpdikqivshlr

S-QRMKMVQTKDQFLFIYH
   |   ||| .|...|..
vtgraasvqtlqqymliwk

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 181-328 8.1e-09 29.3 In-house 152-284 (302) alignment
Range on Protein: 181-328
Range on HMM: 152-284/302.0
FVNVHKVKDYYTVT---DIKLTPTDPLVGPVKTVHHFyfDLWKDMNKPEEVVPIMELCAHSHSLNSRGN-PIIVHCSAGVGRTGTFIALDHLMHdTLdfk
|||. ||.     .    | . | .    .. .| ..  . ||. . |...  ...  |. . ... .. ....    |.|| |.|..|   .. .|   
fvNnrkVekaeeektryviEvlPegcsnsvlanvyvl..tnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavave.kl...

niTERS--RhsdrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHAAKYL
  .. .  .             |..|| ..|||| ..|.. .|. ..| |. ..
..qkgkepn.............ikeivksiRsqRpravdslkQyvslyiallly

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 47-130 1.1e-08 29.0 In-house 91-168 (244) alignment
Range on Protein: 47-130
Range on HMM: 91-168/244.0
SIEPRNDARNRYVNIMPYERNRVHLK-TLSGNDYINASYVKvnVPGQSIEpgyYIATQGPTRKTWDQFWQMCYHNCplDNIVIVM
...| |  .||    .|.. ||| |     || |||||.|     |.. |   || || |   |  .||.|        |...|.
afnpnnswknregaglpfdfnrvplskgsmgntyinasfvg..clgrtae...yiltqhpladtsmdfwkmmlerh..vnvlvvl

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 51-87 7.2e-08 26.5 In-house 47-83 (95) alignment
Range on Protein: 51-87
Range on HMM: 47-83/95.0
RNDARNRYVNIMPYERNRVHLKTLSGNDYINASYVKV
 |  .||..||.||.  || | |    ||||| .|  
anipknrflnifpydatrvvlttkrdsdyinacfvdg

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 209-315 7.7e-08 26.7 In-house 116-207 (255) alignment
Range on Protein: 209-315
Range on HMM: 116-207/255.0
KTVHHFYFDLWKDMNKPEEVVPIMELCAHSHslNSrgNPIIVHCSAGVGRTGTFIaldhlmhdtlD----FKNITERSRHSDRATEEYtRDLIEqivlQL
.||.|. .  | . | ||.   |...    .  .|   ...||||.|.||. .|.               ....    . .. .  .| . |.|    .|
htvkhysykGWieknaPelareilnilkvvr..ds..ksvvvhCstGiGrsaafv..........laelvyqkmirsldttetveldy.lslle....el

RSQRMKMVQTK
||.| . ..| 
rskrkraihtP

0038934 (Phosphotyrosine protein) phosphatases II 224-265 9.5e-08 27.4 In-house 95-135 (194) alignment
Range on Protein: 224-265
Range on HMM: 95-135/194.0
KPEEVVPIMELCAHSHsLNSRGNPIIVHCSAGVGRTGTFIAL
  | .  ...|. . .  .. |. . ||| ||.|||||..| 
sleillrfldlvdefl.nedpggvvaVHCkaGlgRtGtlvaa

PTEN_1 232-264 1.6e-07 26.3 In-house 117-149 (196) alignment
Range on Protein: 232-264
Range on HMM: 117-149/196.0
MELCAHSHSLNSRGNPIIVHCSAGVGRTGTFIA
 . .... .....|| ..||| ||.||.|| .|
cksfiewllsdpngnvVlVHCkaGlgRsGtvva

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 244-325 1.8e-07 25.3 In-house 209-273 (287) alignment
Range on Protein: 244-325
Range on HMM: 209-273/287.0
RGNPIIVHCSAGVGRTGTFIALDHLMHDTLDFKNItersrhsDRAteeytrdlieQIVLQLRSQRMKMVQTKDQFLFIYHAA
   |..||...|.||.|...|.  |..  .|  ..       | |          ..|..|| .|  .||.  |. ..| | 
evGPlvvhddvGiGrsGillatlvlvsrledlGrv.......dva..........avvirlreyraalvqavvqlrllyeal

subfamily_eak_pd Subfamily eak 53-152 2.1e-07 24.7 In-house 51-145 (332) alignment
Range on Protein: 53-152
Range on HMM: 51-145/332.0
D--ARNrYVNIMPYERNRVHLKTLS--GNDYINASYVKVNVPGQSiepgyYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQYWPR
.   ||  |.|.||.|. |.| .     . ||||| .. .  |.      || |  .  .    |||| . .       ||..   || . ||  .|.| 
eavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrk.....yiltGiasedkvfafwqmvleq...kspaivqlledvelkleksdkyfpd

GGVD
 . .
ktre

subfamily_hpo-7_pd Subfamily hpo-7 208-271 7.2e-07 23.4 In-house 121-180 (263) alignment
Range on Protein: 208-271
Range on HMM: 121-180/263.0
VKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHslNSrgNPIIVHCSAGVGRTGTFIALDHLMHD
..||.|. . .| . | ||.   |...       ||   ...||||.|.||.  |   . .   
thtvkhysykgWiekndpelareilnilkvar..ns..kslvvhcstGiGrsaafsvaElvyqk

0048567 (Phosphotyrosine protein) phosphatases II 212-267 1e-06 23.2 In-house 31-99 (157) alignment
Range on Protein: 212-267
Range on HMM: 31-99/157.0
HH-------FYFDLWKDMNkPEEVVPIMELCAHSHSLNS----RGNPIIVHCSAGV---GRTGTFIALDH
..       .|.|.. |   | ..  ..... . ... .    .|..|.|||.||    |||.|.|..  
lyFsiddglvyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYl

PTPc_motif_SM00404 239-271 2e-06 22.8 In-house 74-106 (140) alignment
Range on Protein: 239-271
Range on HMM: 74-106/140.0
HSLNSRGNPIIVHCSAGVGRTGTFIALDHLMHD
.. ...|  ..||| ||| |..|.|.   .. .
enaekkggkvlVHCqaGvSRSatliiaYlmryr

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 210-266 2.3e-06 22.0 In-house 159-212 (290) alignment
Range on Protein: 210-266
Range on HMM: 159-212/290.0
TVHHFYFDLWKDMNKPEEVVPIMELCahsHSLNSRGNPIIVHCSAGVGRTGTFIALD
|| |  .  |...| .|.   ...|    . .. .. |.||||  |. |  .. |..
tvtHsllkgWnklnvqedtktllsli...qkvkasktpvivHcvdGiSrsAalaaii

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 244-265 2.7e-06 21.3 In-house 225-246 (301) alignment
Range on Protein: 244-265
Range on HMM: 225-246/301.0
RGNPIIVHCSAGVGRTGTFIAL
 | |..||||..|.|.|.....
gggpvvVHCSdtVsrsGvYcsv

DSPc Dual specificity phosphatase, catalytic domain 239-270 2.9e-06 22.2 Pfam-A 67-97 (133) alignment
Range on Protein: 239-270
Range on HMM: 67-97/133.0
HSLNSRGNPIIVHCSAGVGRTGTFIAlDHLMH
... ..|. ..||| ||. |..|.|.  .|| 
ekaeqkgkkvlVHCqaGisRSatlii.aYlmk

DSPc Dual specificity phosphatase, catalytic domain 239-270 2.9e-06 22.2 In-house 67-97 (133) alignment
Range on Protein: 239-270
Range on HMM: 67-97/133.0
HSLNSRGNPIIVHCSAGVGRTGTFIAlDHLMH
... ..|. ..||| ||. |..|.|.  .|| 
ekaeqkgkkvlVHCqaGisRSatlii.aYlmk

subfamily_PTPDC1_pd Subfamily PTPDC1 243-299 5.4e-06 21.0 In-house 113-167 (182) alignment
Range on Protein: 243-299
Range on HMM: 113-167/182.0
SRGnPIIVHCSAGVGRTGTFIALDHLMHDTLDFKNITERSRhSDRATEEYTRDLIEQ
..|  . ||| || ||||  ||   . .. |. ..  .  | | |.   .||. .| 
qeg.kvavhChaGlGrtGvliacylvyakrltaekaiklvr.skrpksiqtreqvel

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 52-120 6.8e-06 19.9 In-house 47-106 (303) alignment
Range on Protein: 52-120
Range on HMM: 47-106/303.0
NDARNRYVNIMPYERNRVHLktlSGNDYINASYVKVNVPGQSiepgyyIATQGPTRKTWDQFWQMCYHN
|  .||.|...  .  .|.|   |   || |||....   ..      | || |  .|  .||||  ..
nmdknrfvdvicldhskvkl...sdssyihasyleldsskka......iltqlplshtaadfwqmiieq

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 249-265 8e-06 20.2 In-house 2-18 (69) alignment
Range on Protein: 249-265
Range on HMM: 2-18/69.0
IVHCSAGVGRTGTFIAL
.||||.| ||||||||.
vvhcssgtgrtgtfiai

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 49-86 8.2e-06 19.4 In-house 44-84 (440) alignment
Range on Protein: 49-86
Range on HMM: 44-84/440.0
EPRNDARNRYVNIMPYERNRVHLK---TLSGNDYINASYVK
 | |  .||| ||. |...|| |.    .  .|||||||..
lpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyin