Gene PHO13 in Saccharomyces cerevisiae

Synonym: YDL236W, PHO13

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HAD
Superfamily HAD
Family NagD
Subfamily PGP
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP016_AA protein Get Run
ScerP016_AA_23-305 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PGP_pd Subfamily PGP 26-306 2.6e-98 319.8 In-house 1-277 (279) alignment 
Range on Protein: 26-306
Range on HMM: 1-277/279.0
TFLFDCDGVLWLGSQALPYTLEILNLLKQLGKQLIFVTNNSTKSRLAYTKKFASFGID-VKEEQIFTSGYASAVYIRDflklQPGKDKVWVFGESGIGEE
|.|||||||||||..|.|.. |.|| ||.|||...||||||||||  ..|||...|.. ||||.|..|..| | |...    .  ..||.|.||.|. ||
tvlfDcDGVlWlgetaipgaaealnaLkklgKkvlfvtNnstksreellkkfkklgfekvkeeeilssaaaiadyLkq....kkfekkvyvlgeeglkee

LKLMGYESLGGADSRLDTPFDaaKSPFLVNGLDKDVSCVIAGLDTKVNYHRLAVTLQYLQKDSVHFVGTNVDSTFPQKG-YTFPGAGSMIESLAFSSNRR
|| .|.|.||. ...|....|  .. .    |||||..|. |.|.|..|..|. . .||....|.|..|| |...|.|  ...|||||.....  .|.|.
Lkeagiellgtgpeklkdeld..edfveelkldkdvgAVvvgvdeklsyakllkAanyLrepevlflatneDallplkkevvipgaGslvaaieaasgrk

PSYCGKPNQNMLNSIISAFNLDRSKCCMVGDRLNTDMKFGVEGGLgGTLLVLSGIETEERALKISHD-YPRPKFYIDKLGDIYT
| ..||||...|.........|.....|.||||.||..|| . ||  |||||||....|.. .|...  . |..|.|.|.|...
plvlGKPnelllelllekeeidpertlmiGDrlktDilfgkncGl.qtLlvlsGvtkledveeikkeeklvPdyyldsladlle
Chronophin_1 25-305 6.3e-67 216.7 In-house 2-256 (261) alignment 
Range on Protein: 25-305
Range on HMM: 2-256/261.0
DTFLFDCDGVLWLGSQALPYTLEILNLLKQLGKQLIFVTNNSTKSRLAYTKKFASFGID-VKEEQIFTSGYASAVYIRDflklQPGKDKVWVFGESGIGE
...|.|.||||. | .|.|.  |... ||| ||...||||||.. |  ...... .|.| |..|.||.| .|.|...|.    |. | ||.| ||.|. .
qlvLlDldGVlikgeeavpgAaeliealkqagkevlfvtNnsrrtreelaarlkrlGldavaaeeifssalaaaallrq....qaakakvyvlGeeglrk

ELKLMGYESLGGADSrldtpfdaakspflvngldkDVSCVIAGLDTKVNYHRLAVTLQYLQKDsVHFVGTNVDSTFPQKGYTFPGAGSMIESLAFSSNRR
||.  |.   ....                     .|. |. | | ......||   .....    || || | |.|..    ||.||..  .   |.|.
elreaGlrlvdeped....................rveaVvvGydeelsfeklaeaialirdg.alfvatnrDptvPleeGiaPgtGslaaaveaAsgre

PSYCGKPNQNMLNSIISAFNLDRSKCCMVGDRLNTDMKFGVEGGLGgTLLVLSGIETEERALKISHDYpRPKFYIDKLGDIY
| . |||.  | ... . ...| ..  ||||||.||...| . ||  |||||.|. ..| | .. .|. ||....... |. 
plvvGKPepvmfeealekigadpeetvmvGDRldTDilagaragls.tllvltGvseleeaqaykkdl.rPdavvesiadll
Chronophin_2 26-301 2.9e-59 191.7 In-house 2-273 (282) alignment 
Range on Protein: 26-301
Range on HMM: 2-273/282.0
TFLFDCDGVLWLGSQALPYTLEILNLLKQLGKQLIFVTNNSTKSRLAYTKKFASFGI-DVKEEQIFTSGYASAVYIRDFLKLQpgkDKVWVFGESGIGEE
. |||||||.| | .|.. . |....|...||. .|||||||..|  |..||| .|. ||..||||.| | || |.||  ...    ||.|.|  |. .|
nvlfdcdgviwngekavagapevvsrlaragknvlfvtnnstrarenyvlkfarlgfadvaaeqifssaycsaaylrdvadvr...gkvfviggeglrke

LKLMGYESLGGADSRLDTPFDAAKSPflvngldkDVSCVIAGLDTKVNYHRLAVTLQYLQKDSVHFVGTNVDSTFPQ-KGYTFPGAGSMIESLAFSSNRR
|.  | . .. || .  . .|.|..|        ||  |. | | |. . .|| .  ||.     .. |. |   |  .|   ||.||.  .|  .|.|.
lreagvpvvedadeqeasiydcaldp........dvravlvgydekltflklakacaylrdadclllatdrdpwhplsdgritpgsgsltaaletasgrk

PSYCGKPNQNMLNSIISAFNLDRSKCCMVGDRLNTDMKFGVEGGLGgTLLVLSGIETEERALKISH------DYPRPKFYIDKL
    ||| . |.. | | |..| ... |.||||.||. || . ||  |.| |.|. . | | . |.          |..... .
atvigkpsrfmfecissqfsvdparslmigdrletdilfgsncgls.tvltltgvssleeaqeysdsqlaeqrdlvpdyvvesi
Hydrolase_6 Haloacid dehalogenase-like hydrolase 27-131 1.8e-29 93.1 Pfam-A 1-101 (101) alignment 
Range on Protein: 27-131
Range on HMM: 1-101/101.0
FLFDCDGVLWLGSQALPYTLEILNLLKQLGKQLIFVTNNSTKSRLAYTKKFASFGIDVKEEQIFTSGYASAVYIRDflklQPGKDKVWVFGESGIGEELK
||||.||||| |..|.|   |.|. |.. ||.....||||.||. .| ||. ..|.||.|||..||..| | |...    .....||.|.|| |. ||||
flfDvdGvLwrgdkaipgaaealkalraagkpvvllTNnsskseeeyakkleklgvdvteeqvvtsataaaeylkk....rkadkkvlvigeeglreelk

LMGYE
 .|..
eaGfk
subfamily_LHPP_pd Subfamily LHPP 27-272 4.2e-26 83.3 In-house 1-215 (227) alignment 
Range on Protein: 27-272
Range on HMM: 1-215/227.0
FLFDCDGVLWLGSQALPYTLEILNLLKQLGKQLIFVTNNSTKSRLAYTKKFASFGIDVKEEQIFTSGYASAVYIRDFLKlqpgkdKVWVFGESGIGEELK
.| |  |||. ...|.| . |.|. |.| |... ||||.. .|. | ...   .|.||.||.||||. | . ..|.         . ... |..  |...
vllDlsGvlhnedaaipgavealkrLrqagvkvrfvtNttkeskralverLirlgfdveeeeiftsleaarqllrerkl......rpyllveddveedfe

LMGYESLggadsrldtpfdaakspflvngldkdvSCVIAGL-DTKVNYHRLAVTLQYLQK-DSVHFVGTNVDSTFP-QKGyTFPGAGSMIESLAFSSNRR
 . ...                             .|. || . ...|..|  . . | . .  . .  | .  .  ..|    |.|. ...| .. . .
didtdkp...........................navviglapesfeyetlnqafrllleakkakliainkgkyykrkdG.lalgpGafvkaleyatgvk

PSYCGKPNQNMLNSIISAFNLDRSKCCMVGDRLNTDMKFGVEGGLGGTL
  . |||.... .. ......| ... |.|| .. |..  .. || | |
aevvGKPsalffekaleelgvdpeeavmiGDdvedDveGAlkaGlrgvl
Hydrolase haloacid dehalogenase-like hydrolase 24-264 8.8e-19 60.0 Pfam-A 1-212 (215) alignment 
Range on Protein: 24-264
Range on HMM: 1-212/215.0
YDTFLFDCDGVLWLGSQAL--PYTLEILNLLKQL--------GKQLIFVTNN-STK-SrLAYTKKFASFGIDVKEEQIftsgyasavyirdflklqpgkd
..|..||..|.|. |....  . . ..|.|...|        ||...... . ||. . | .  .|.  |.  | . |                      
iktvvfDktGTLtegepsvallgnkaalalaaaletgsehpigkavvaaakanstrgg.ltgfatfigrgvsgkvdgi......................

kvwVFgesGIGEELK---------------------------LmgyeslggadsrldtpfdaakspflvngldkDVSCVIAGLDTKVNYHRLAVTLQYLQ
   |    |  | ..                                                           ..  .    ..   .  .| ....|.
...vl...gnpewmtalglrviapdlvaaegqskgrtvvvvav...............................qaralgviafadpvkpeaaeavasLk

KDSV-HFVGTNVDSTFPQKGYTFPGA-GSMIESLAFssnrrpsycGKPNQNMLNSIISAFNLDRSKCCMVGDRLnTDMKFGV
.  .  .. |.  .   ..  ...|  .|..   ..         |||.. ... .| ....|.....||||.. .|.... 
eaGievvlltgdnpetaeaiakqagiedslvfaevv.........gkPepklfvaaieeLqidpgevamvGDgv.nDapala
Hydrolase_like HAD-hyrolase-like 226-303 4.4e-15 46.7 Pfam-A 1-74 (75) alignment 
Range on Protein: 226-303
Range on HMM: 1-74/75.0
YCGKPNQNMLNSIISAFNLDRSKCCMVGDRLNTDMKFGVEGGLgGTLLVLSGIETEERALKISHdypRPKFYIDKLGD
..||||  |. ..   .... |...|.||.|.||.... . |.  ..|||.|. .||.. .  .   .|....| | .
vlgKPnpgmydkalevlgappsevvmiGDslatDieaAnnaGi.rsilVltGvsreedlklaka...kpdyvvddlee
CECR5_TIGR01456 26-92 9.7e-07 18.5 In-house 40-111 (370) alignment 
Range on Protein: 26-92
Range on HMM: 40-111/370.0
TFLFDCDGVLWLGSQALPYTLEILNLLKQLG----KQLIFVTNNSTKSRLAYTKKFAS-FGIDVKEEQIFTS
.|..| |||| .|.. .. ... | .| .        ....||    |  | ......  |..|. .|.  |
gfaldiDGvllrGkkpiagaskalrrLvddqGalkiPvllltngGglseraraeelsalLgvevsplqviqs
Subfamily.CECR5.protein 24-92 1e-06 18.4 In-house 20-93 (393) alignment 
Range on Protein: 24-92
Range on HMM: 20-93/393.0
YDTFLFDCDGVLWLGSQALPYTLEILNLLKQLGK----QLIFVTNNSTKSRLAYTKKFA-SFGIDVKEEQIFTS
  ....| ||||  | . .| . | |.||..         .|.||..  .  . ..| .   ...|. .|.. |
kfgivlDiDGvLlRgkkvipaakealklledkkgelkvPvvfltnggnftekekaeklsekLdvevdadqvlls
subfamily_CUT_pd Subfamily CUT 26-92 1.5e-06 18.0 In-house 20-91 (391) alignment 
Range on Protein: 26-92
Range on HMM: 20-91/391.0
TFLFDCDGVLWLGSQALPYTLEILNLLKQLGK----QLIFVTNNSTKSRLAYTKKFA-SFGIDVKEEQIFTS
....| ||||  | . .| . | |.||..         .|.||..  .  . ..| .   ...|. .|.. |
givlDiDGvLlRgkkvipaakealklledkkgelkvPvvfltnggnftekekaeklsekLdvevdadqvlls