Gene CDC14 in Saccharomyces cerevisiae

Synonym: OAF3, YFR028C, CDC14

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily CDC14
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP027_AA protein Get Run
ScerP027_AA_7-156 phosphatase_domain Get Run
ScerP027_AA_175-340 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_CDC14_pd Subfamily CDC14 8-342 9.1e-139 456.9 In-house 1-327 (328) alignment 
Range on Protein: 8-342
Range on HMM: 1-327/328.0
DNTIEFLRGRVYLGAYDYTPEDTDELVFFTVEDAIFYNSFHLDFGPMNIGHLYRFAVIFHEILNDPENANKAVVFYSSASTRQRANAACMLCCYMILVQA
||..|.|..|.|.......|..|.||..|.|.|...|..|. ||||.|...|||..| ....|...|.|.|..|.|.||....|||||.....|......
dnalelledrlyfatlrkkPkstselhyfsvddelkyenfyadfGPlnlavlyrycvklnkkLkseekaskkivlytsadskkranaalligayaviylk

WTPHQVLQPLAQVD-PPFMPFRDAGYSNADFEITIQDVVYGVWRAKEKGLIDLHSFNLESYEKYEHVEFGDFNVLTPD-FIAFASPqedHPKGYlATKSS
.|.......|.... |||.|||||.|..|....|..||..||..|..||..||..|.||.|||||.||.||||...|| |.|.|.|   |.| . .....
ktaeeayraleaaetppfvpfrdasygsasykltlldvlkgvekalqkgfldledfdleeYekyervenGDfnwivPdkflalagP...hnksk.ledgy

HLNQPfKSVLNFFANNNVQLVVRLNSHLYNKKHFEDIGIQHLDLIFEDGTCPDLSIVKNFVGAAETIikrGGKIAVHCKAGLGRTGCLIGAHLIYTYGFT
.|..| ...|..|..|||. |||||..||..|.|.|.|..| ||.|.||..|. .|||.|. .||..    |.|||||||||||||.||...|...|.||
plhaP.eklleyfrknnvttvvrLnkklYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka...eGaiavhCkaGLGrtGtLiacylmkhyrft

ANECIGFLRFIRPGMVVGPQQHWLYLHQNDFreWKYT
|.|.|..||..|||.|.||||..|. .|...  |...
aaeaiawlricrPGsvigpqqkfleekqaal..wleg
DSPn Dual specificity protein phosphatase, N-terminal half 11-151 1.5e-52 168.1 Pfam-A 1-141 (141) alignment 
Range on Protein: 11-151
Range on HMM: 1-141/141.0
IEFLRGRVYLGAYDYTPEDTDELVFFTVEDAIFYNSFHLDFGPMNIGHLYRFAVIFHEILNDPENANKAVVFYSSASTRQRANAACMLCCYMILVQAWTP
||....|.|. ... .|..|.....|...... |..|. ||||.|....|||.|  ...|...|...|..|.|.| ....|||||.....|...|. ..|
ieliedrLyfvslkkkpkktenthyfsiDeelvYepfyadFGPlnlaqiyrfcvklnkkLkeaelkkkkivlytsldekkranaalLigaYavivlklsp

HQVLQPLAQVDPPFMPFRDAGYSNADFEITIQDVVYGVWRA
...|.||..|.|...||||| |.....|.||.|...|...|
eealkplesvepsllpFrDAsygestyeltildclkglekA
0048567 (Phosphotyrosine protein) phosphatases II 7-159 7.2e-52 169.7 In-house 4-156 (157) alignment 
Range on Protein: 7-159
Range on HMM: 4-156/157.0
LDNTIEFLRGRVYLGAYDYTPEDTDELVFFTVEDAIFYNSFHLDFGPMNIGHLYRFAVIFHEILNDPENANKAVVFYSSASTRQRANAACMLCCYMILVQ
. ..||.. .| |. .. . |... ....|...| ..|..|. ||||.|...||||.......|...|.|.||......|. ..|...|....||.||..
ngdlieiipdrlyfallprlpkslynalyFsiddglvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhl

AWTPHQVLQPLAQVDPPFMPFRDAGYSNADFEITIQDVVYGVWRAKEKGLIDL
 .||.....||..|.|...|||||.|.......|..||.||...|.| |..||
gftpeeaiaplrivrpgsvpfrdasyllslynltlldvlyGllkAlelgfldl
0038934 (Phosphotyrosine protein) phosphatases II 167-329 2.6e-41 136.8 In-house 6-168 (194) alignment 
Range on Protein: 167-329
Range on HMM: 6-168/194.0
YEKYEHVEfgdfNVLTPDFIAFASPQEDHPKGYLAtksSHLNQPFKSVLNFFANN--NVQLVVRLN--SHLYNKKHFEDIGIQHLDLIFED-GTCPDLSI
..|||.|.    .. |..||||..| ...   |.    ...  .........  .  .. ||..|.  ...|....||. ||..|.|.|.| ||.|.|.|
wlkyervg....diitgrfiafkvPlsgsldkyie...elyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPslei

VKNFVGAAETIIKR--GGKIAVHCKAGLGRTGCLIGAHLIYTYGFTANECIGFLRFIRPGMVVGPQQHWL
...|. ........  ||..||||||||||||.|..|.|||..|..|.|.|...|..|||..  ...   
llrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdylea
0043147 (Phosphotyrosine protein) phosphatases II 166-336 2.6e-38 126.8 In-house 3-159 (172) alignment 
Range on Protein: 166-336
Range on HMM: 3-159/172.0
SYEKYEHVEFGDFNVLTPDFIAFASPqedhpkgylatksshLNQPFKSVLNFFANNNVQLVVRLNSHLYNKKHFEDIGIQHLDLIFEDGTCPDLSIVKNF
....|..... |... ...|||.  |               |. .. ...... .......|.|...||.....|. |||.| | ..|...|.|... .|
egsdyinasyldlyyipdrfiatqgp...............lrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvpllelllef

VGAAET--IIKRGGKIAVHCKAGLGRTGCLIGAHLIYtYGFTANECIGFLRFIRPGMVVGPQQHWLYLHQNDF
.   ..  ....||...|||.||.||||.|. |.|.. .|... |.. ..|  |||.|  |.|... .. ...
lefidellalspggpvlVHCsaGvgRtgtlvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfekl
0040438 (Phosphotyrosine protein) phosphatases II 135-342 1.5e-35 118.4 In-house 3-281 (317) alignment 
Range on Protein: 135-342
Range on HMM: 3-281/317.0
ADFEITIQDVVYGVWRAKEKGLIDLHSFNLESYEKYEHVEFGDFNVL-----------------------------------TPDFIAFASPQedhpkgy
 |.. ...|.... ..| ... .|| |..|..|. .|..| .|.|                                     .. |||. .|.       
ldlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPl.......

latksshlNQPFKSVLNFFANNNVQLVVRLNSHLYN------------------------KKHFEDIGIQHLDLIF-------------------EDGTC
        .. . . .... ...|...|.|..  ..                        .. .|. ||... | .                    |...
........pntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgv

P-DLSIVKNFVGAAETIIKR-GGKIAVHCKAGLGRTGCLIGAHLI-----YTYGFTANECIGFLRFIRPGMVVGPQQ-HWLYLHQNDFREWKYT
| ..... .|. |... ... ||...|||.||.||||..|.| |.     ...|... |.. .||  |||.|  |.| ..||   ...  .|.|
ppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrklt
0049772 (Phosphotyrosine protein) phosphatases II 122-332 2.7e-35 118.0 In-house 64-274 (314) alignment 
Range on Protein: 122-332
Range on HMM: 64-274/314.0
PPFMPFRDAGYSNADFEITIQDVVYGVWRaKEKGLIDLHSFNLESYEKYEHVEFGDFNVLTPDF---------------------IAFASPQEdhpkgyl
.|..|... .| ||..  .... ..  .  .| ...|......  |.....|. ||.|| ..                       .  ....        
lpglpvsgsdyinasyvdgflkfIatqgp.leitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng.......

atksshlNQPFKSVLNFFAnnnvqlvvrlnSHLYNKKHFEDIGIQHLDLIFEDGTCPDLSIVKNFVGAAETIiKRGGKIAVHCKAGLGRTGC-LIGAHLI
       |.|  . | ..            . ||....||. ||..|.. ..||..|.|.... |. . |.  ..||...|||||| ||||. .. | |.
.......neptaadlellk...........eelydpelferlgikylripvpDgsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylm

YTYGFTANECIGFLRFIRP-----GMVVGPQQHWLYLH
. .|....|.. ..| .||     |..  ..| . .|.
kllgvsleealedvrlkRpinpnpgfieqleqyefile
0041856 (Phosphotyrosine protein) phosphatases II 162-331 3.4e-34 113.4 In-house 2-164 (182) alignment 
Range on Protein: 162-331
Range on HMM: 2-164/182.0
FNLESYEKYEHVEFG-DFNVLTPDFIAFASPQEDhpkgYLATKSSHLNqPFKSVLNFFANNNVQLVVRLNSHLYNKKHFEDIGIQHLDLIFEDGTCPDLS
.... |... ..... |..  .. ..... |. .    ..||.  .|.  . . |... .......|.|...||. ...|. |||.|.| ..|...|||.
ldknrysdilpydhsrdldyInanlylgslpatr....fiatqgplls.tvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpdld

IVKNFVGAAETiikRGGKIAVHCKAGLGRTGCLIGAHLIYTYGFTANECIGFLRFIRPGMVVGPQQHWLYL
.. .|. ...    .||...|||.||.||||.|..| |....|... |.. ..|  |||||. |.|.... 
elldfieevle...eggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflq
0048567 (Phosphotyrosine protein) phosphatases II 222-334 6.2e-34 111.5 In-house 16-135 (157) alignment 
Range on Protein: 222-334
Range on HMM: 16-135/157.0
NVQLVVRLNSHLYNKKHF-EDIGIQHLDLIFEDGtCPDLSIVKNFVGAAETIIK----RGGKIAVHCKAGL---GRTGCLIGAHLIYTYGFTANECIGFL
.. |..||...||| ..|  | |....|..|..| ...|.|. .|.  .. ..|    .|..|||||||||   |||..|||..||. .|||..|.|..|
yfallprlpkslynalyFsiddglvyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiapl

RFIRPGMVVGPQQHWLYLHQN
|..|||.|.......|....|
rivrpgsvpfrdasyllslyn
0044763 (Phosphotyrosine protein) phosphatases II 160-337 8.6e-33 108.8 In-house 5-171 (178) alignment 
Range on Protein: 160-337
Range on HMM: 5-171/178.0
HSFNLESYEKYEHVEFGDFNVLTPDFIAFASPQedhpkgylatksshlnqpfKSVLNFFANNNVQLVVRLNSHLY------NKKHFEDIGIQHLDLIFED
. ..|...| .| ... ...  .|.... . |.                    . |... .......|.|.. |.      .....|. |||.| . ..|
trvllsnleglersdyinaseilpglylgslpp...................addlellkelgithivnlteelelgflkcdpywpeeagiqylhipipD

GTCPD-LSIVKNFVGAAETII-KRGGKIAVHCKAGLGRTGCLIGAHLIYTYGFTANECIGFLRFIRPGMVVGPQQHWLYLHQNDFR
...|| |... .|| . |... ..||...|||.||.||.|.|. | |....|....|.| ..|  ||..    |...||. .  ..
hgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRpivpnpgqlrqLyefelrll
0039614 (Phosphotyrosine protein) phosphatases II 124-338 1.5e-32 108.7 In-house 1-290 (297) alignment 
Range on Protein: 124-338
Range on HMM: 1-290/297.0
FMPFRDAGYSNADFEITIQDVVYGVWRAKEKGLIDLHSFNL----ESYEKYEHVEFGDFNVL-------------------------------------T
..|.||| ... .. ....|.......|..|.|..|. ..|    ..|. ....| .|.|                                       |
ylplrdallesipiplsvldlllllekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydllt

PDFIAFASPQEDhpkgylatksshlnqPFKSVLNFFANNNVQLVVRLNSHLYNKKHF----------------EDIGIQHLDLIF---------------
..|||.  |...                ... .... ...|. .|.|..  ......                . ....||| ..               
rkfIatqgPlpe...............tvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtv

--------EDGTCP-DLSIVKNFVGAAETIIK---RGGKIAVHCKAGLGRTGCLIGAHLI-----YTYGFTANECIGFLRFIRPGMVVGPQQ-HWLYLHQ
         |...| .|... .|. .......   .||...|||.||.||||..|.| |.     ...|... |.. .||  |||.|  |.| ..||   
thfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydal

NDFRE
 ... 
lellk
0045450 (Phosphotyrosine protein) phosphatases II 121-332 1.7e-32 108.8 In-house 2-297 (307) alignment 
Range on Protein: 121-332
Range on HMM: 2-297/307.0
DPPFMPFRDAGYSNADFEITIQDVVYGVWRAKEkGLIDLHSFNLESYEKYEHVEFGDFNV----------------------------------------
|.|...|.|| ..   . ....| ..|.... |  |.... | | .|. ....| .|.|                                         
dlplslfidalkllllvllllldfltgllkefe.kllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvplllll

----LTPDFIAFASPQEDhpkgylatksshlnqPFKSVLNFFANNNVQLVVRLNSHLYNKKH--------------------------------------
    |.  |||. .|...                ... .... ...|...|.|..  ....                                       
dgydlkrkfIatqgPlpe...............tvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlev

----FEDIGIQHLDLIF---EDGTCP-DLSIVKNFVGAAETIIK---RGGKIAVHCKAGLGRTGCLIGAHLIYTYG--------FTANECIGFLRFIRPG
    ... ....  ...    |...| ..... .|. .......   .||...|||.||.||||..|.| |.....        ... |.. .||  |||
tdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpg

MVVGPQQhWLYLH
.|  |.| . .|.
avqnpeq.yrfly
0036282 (Phosphotyrosine protein) phosphatases II 169-327 1.3e-31 105.0 In-house 3-159 (174) alignment 
Range on Protein: 169-327
Range on HMM: 3-159/174.0
KYEHVEFGDFNVLTPDFIAFASPQEdhpkgylatksshlnqpfksVLNFFANNNVQLVVRLNSHLYNK------------KHFEDIGIQHLDLIFEDGTC
.|... . |... || .||.. | .                     . .. ..... ||.|..  ...            ...|. |||.|.| ..|...
dyinaspldlsyitprliagqgpla....................fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgv

PDLSIVKNFVGAAETIIKR--GGKIAVHCKAGLGRTGCLIGAHLIYTYGF-TANECIGFLRFIR---PGMVVGPQQH
|||||. .|| ..|.....  ||...|||.||.||||.|..| |...... .. . . ..| .|   ||||  |.| 
pdlsillefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQy
0049260 (Phosphotyrosine protein) phosphatases II 207-331 1.5e-31 104.6 In-house 18-143 (152) alignment 
Range on Protein: 207-331
Range on HMM: 18-143/152.0
LNQPFKSVLNFFANNNVQLVVRLNSHLYNKKHFEDIGIQHLDLIFEDGTCPDLSIVKNFVGAAETI--IKRGGKIAVHCKAGLGRTGCLIGAHLIYtYGF
............ ..... .|.|...|...| ... .||.| | ..|...||||..  |.  .  .  ...||...|||.||.||||.|. | |.. .|.
gpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.lgv

TANECIGFLRFIRPGMVVGPQQHWLYL
.. |.. ..|  |||.|  |.| .. .
sleeavalvrekRpgavpnpgqlrfly
0043336 (Phosphotyrosine protein) phosphatases II 132-328 2.8e-31 104.4 In-house 2-266 (278) alignment 
Range on Protein: 132-328
Range on HMM: 2-266/278.0
YSNADFEITIQDVVYGVWRAKEKGLIDLHSFNLESYEKYEHVEFGDFNVL-----------------------------------TPDFIAFASPQEDhp
.|  |.. ............ ...  .|.||.|..|. ....| .|.|                                     ...|||.  |...  
isvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe..

kgylatksshlnqPFKSVLNFFANNNVQLVVRLNSHL--------------------------------------------YNKKHFEDIGIQHLDLIfE
              ..   ... ...|. .|.|..                                              .... ..  ....|.   .
.............tvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp.d

DGTCPDLSIVKNFVGAAETIIK-RGGKIAVHCKAGLGRTGCLIGAHLI-----YTYGFTANECIGFLRFIRPGMVVGPQQhW
.|....||.. .|. |. .... ..|...|||.||.||||..|.. |.     ...|... |.. .||  |||.|  |.| .
hgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsq.y
0045098 (Phosphotyrosine protein) phosphatases II 182-340 4.1e-31 103.8 In-house 63-275 (278) alignment 
Range on Protein: 182-340
Range on HMM: 63-275/278.0
TPDFIAFASPQEdhpkgylatksshlnQPFKSVLNFFANNNVQLVVRLNSHLYNK---------------------------------------------
.. |||.. | .               . . . .... ..... .|.|.. ....                                             
pkkfIatqgPlp...............stvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltve

-KHFEDIGIQHLDL-IFEDGTCPDLSIVKNFVGAAETIIK-----------------RGGKIAVHCKAGLGRTGCLIGAHLIYTY---GFTANECIGFLR
 ...|  |..||..  ..|...|.|.|.| |  . | | .                 .||...|||.||.||||.|..|.|....   |... |.. .||
redlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelr

FIRPG-MV-VGPQQHWLYLHQNDFREWK
  ||| .|    |...||  . ......
sqRpglavqnleqyrflyefllelllrg
0050432 (Phosphotyrosine protein) phosphatases II 116-329 5.7e-31 103.4 In-house 3-290 (308) alignment 
Range on Protein: 116-329
Range on HMM: 3-290/308.0
PLAQVDPPFMPFRDAGYSNADFEITIQDVVYGVWRAKEKGLID------LHSFNLESYEKYEHVEFGDFN------------------------------
..... .....|||..... .......|... ...|...||..      |. ..|..|. ....| .|.|                              
lildallelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgy

--VLTPDFIAFASPQedhpkgylatksshlNQPFKSVLNFFANNNVQLVVRLNSHLYNKK-----HFEDI---GIQHLDLIF------------------
   |.  |||. .|                .. ...    . ..||...|.|..  .|..      . .    |... . ..                  
ssklprkfIatqgPl...............pntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtle

---------------------EDGTCPDLSIVKNFVGAAETIIkRGGKIAVHCKAGLGRTGCLIGAHLI-----YTYGFTANECIGFLRFIRPGMVVGPQ
                     ..|..|...|. .|. .... . .||.|.|||.||.||||..| . |.     ...|... |.. .||  ||||| .|.
ltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpe

QHWL
|...
qylf
0046846 (Phosphotyrosine protein) phosphatases II 175-328 7.5e-31 102.6 In-house 9-163 (176) alignment 
Range on Protein: 175-328
Range on HMM: 9-163/176.0
FGDFNVLTPDFIAFAspqedhpkgYLATKSSHLNQPFKSVLNFFANNNVQLVVRLNSH--------LYNKKHFEDIGIQHLDLIFEDGTCPDLSIVKNFV
..|.. .....|. .         . ...   |.. . . | .. ......||.|...         .  . .|. |||.| | ..|...|||... ...
dldldyinanlilgs.........rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllell

GAAETIIKRGGKIAVHCKAGLGRTGCLIGAHLIYT-YGFTANECIGFLRFIRP-GMVVGPQQHW
 . .. .|.||...|||.||.||||.|. | |... .|....|.. ..| .|| |.|  |.| .
efirealkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyr
0042113 (Phosphotyrosine protein) phosphatases II 163-327 8.6e-29 96.1 In-house 32-232 (245) alignment 
Range on Protein: 163-327
Range on HMM: 32-232/245.0
NLESYEKYEHVEFGDFNVLTPDFIAFASPQEDhpkgylatksshlnqPFKSVLNFFANNNVQLVVRLNSHLYN---------------------------
. .    | .  . |.   || |||.. |...                ..  .... ..... .|.|..  ..                           
ggdldsdyinasyvdgyritpkfiatqgPlpe...............tvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllse

----------------KKHFEDIGIQHLDLIFEDGTCPD-LSIVKNFVGAAETIIK--RGGKIAVHCKAGLGRTGCLIGAHLI-----YTYGFTANECIG
                .....  .|... | ..|...|| |... .|. .......  ..|...|||.||.||||..|.| |.     ...|... |.. 
ehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavk

FLRFIRPGMVVGPQQH
.||  |||.|  |.| 
elrsqRpgavqtpsqy
DSPc Dual specificity phosphatase, catalytic domain 199-334 2.6e-28 93.6 Pfam-A 2-132 (133) alignment 
Range on Protein: 199-334
Range on HMM: 2-132/133.0
YLATKSSHLnQPFKSVLNFFANNNVQLVVRLNsHLYNKKHFEDIGIQhLDLIFEDGTCPDLSIVKNFVGAAetiIKRGGKIAVHCKAGLGRTGCLIGAHL
||..||..  ..... |.. ...||.  |. | ....|...|...|. ..   |. ....|. ...|. .|   ...|.|..|||.||. |...|| |.|
ylgskstas.lalleklgitlvinvtkevpnn.naikkseieylrip.vedetetkiskeleeavefieka...eqkgkkvlVHCqaGisRSatliiaYl

IYTYGFTANECIGFLRFIRPGMVVG-PQQHWLYLHQN
..|.....||.. |..  |. ..    ....|. ...
mktknlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 199-334 2.6e-28 93.6 In-house 2-132 (133) alignment 
Range on Protein: 199-334
Range on HMM: 2-132/133.0
YLATKSSHLnQPFKSVLNFFANNNVQLVVRLNsHLYNKKHFEDIGIQhLDLIFEDGTCPDLSIVKNFVGAAetiIKRGGKIAVHCKAGLGRTGCLIGAHL
||..||..  ..... |.. ...||.  |. | ....|...|...|. ..   |. ....|. ...|. .|   ...|.|..|||.||. |...|| |.|
ylgskstas.lalleklgitlvinvtkevpnn.naikkseieylrip.vedetetkiskeleeavefieka...eqkgkkvlVHCqaGisRSatliiaYl

IYTYGFTANECIGFLRFIRPGMVVG-PQQHWLYLHQN
..|.....||.. |..  |. ..    ....|. ...
mktknlslneAyefvkerrskispnagflrqLleyer
0051082 (Phosphotyrosine protein) phosphatases II 175-332 5.2e-28 92.9 In-house 5-147 (151) alignment 
Range on Protein: 175-332
Range on HMM: 5-147/151.0
FGDFNVLTPDFIAFASPQEdhpkgylatksshlnqpfkSVLNFFANNNVQLVVRLNSHL---YNKKHFEDIGIQHLDLIFEDGTCPDL----SIVKNFVG
. .|. .|. ..... | .                    .|......... .| |.|     |... ... ||..|.. ..| . |.|     .|..|. 
yinfsyvtgglyrsggpla...................dflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavlefle

AAETiiKRGGKIAVHCKAGLGRTGCLIGAHLIYtYGFTANECIGFLRFIRPGMVVGPQQHWLYLH
...   |..|...|||.||.||||.|... |.. .|....|.. ..| .|||.|  .||....|.
llld..kkngpvlvHCsaGkgRTGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlf
0040439 (Phosphotyrosine protein) phosphatases II 169-331 6.7e-28 93.4 In-house 40-238 (249) alignment 
Range on Protein: 169-331
Range on HMM: 40-238/249.0
KYEHVEFGDFNVLTPDFIAFASPQEDhpkgylatksshlnqPFKSVLNFFANNNVQLVVRLNSHL-----------------------------------
 | .  . |.   ...|||.  | ..                ... .... ..... .|.|.|                                     
dyinAsyidgyyikrrfiatqgPlpe...............tvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddy

----------YNKKHFEDIGIQHLDLIfEDGTCPDLSIVKNFVGAAETIIK---RGGKIAVHCKAGLGRTGCLIGAHLI-----YTYGFTANECIGFLRF
          |......  .||..|.  ..|..|..... .|. |......   .||...|||.||.||||..|.| |.     ...|... |.. .|| 
tvrtleltnlydgesrtvlhiqytdwp.dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrs

IRPGMVVGPQQhWLYL
 |||.|  |.| . .|
qRpgavqnpeq.yrfl
0048179 (Phosphotyrosine protein) phosphatases II 212-330 2.5e-27 90.7 In-house 19-138 (144) alignment 
Range on Protein: 212-330
Range on HMM: 19-138/144.0
KSVLNFFANNNVQLVVRLNSHlYNKKHFEDIGIQHLDLIFEDGTCPDL-SIVKNFVGAAETIIKRGGKIAVHCKAGLGRTGCLIGAHLIYTYGFTANECI
 . | ....... .|..|... | . ..|. |||.| | ..|  .||| ... .|. . |.....||...|||.||.||||.|. |.|....|....|..
aldlellkklgittvinltee.yepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmkklglsleeal

GFLRFIRPGMVVGPQQ-HWLY
 ..| .|||.|  |.| ..|.
alvrsrrpgavpnpgqlrfLl
0037934 (Phosphotyrosine protein) phosphatases II 177-329 1.4e-26 89.0 In-house 38-234 (243) alignment 
Range on Protein: 177-329
Range on HMM: 38-234/243.0
DFNVLTPDFIAFASPQEDhpkgylatkssHLNQPFKSVLNFFANNNVQLVVRLNSHL------------------------------------------Y
..   || .||.  | ..            ...   | .... ..... .| |..                                            .
nliyvtprliatqgPlpe...........tveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenl

NKKHFEDIGIQHLDLIFEDGTCPD-LSIVKNFVGAAETIIKR---------GGKIAVHCKAGLGRTGCLIGAHLIYTY-GFTANECIGFLRFIRPG-MVV
. ....  .|... | . |...||  ... .|. .. ..|..         ||...|||.||.||||.|| | |.... |... |.. .||  ||| .| 
dlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavq

GPQQ-HWL
 |.| ..|
tpsqyrfl
0048076 (Phosphotyrosine protein) phosphatases II 210-331 2.9e-26 87.3 In-house 17-137 (145) alignment 
Range on Protein: 210-331
Range on HMM: 17-137/145.0
PFKSVLNFFANNNVQLVVRLnshLYNKKHFEDIGIQHLDLIFEDGTCPDL-SIVKNFVGAAETIIKRGGKIAVHCKAGLGRTGCLIGAHLIYTYGFTANE
|  . | ....... .|..|    .... .|. |||.| | ..| ..||| ... .|. . |...|.||...|||.||.||||.|..|.|....|... |
ptaldlellkdlgittvlnl...tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmlllgvslee

CIGFLRFIRPGMVVGPQ-QHWLYL
.. ..|  |||.|  |. ...||.
alelvrsqrpgavpnpgqlrflye
PTEN_1 212-329 4.9e-26 86.8 In-house 54-184 (196) alignment 
Range on Protein: 212-329
Range on HMM: 54-184/196.0
K---SVLNFFANNNVQLVVRLNSHL------YNKKHFEDIGIQHLDLIFEDGTCPDLSIVKNFVGAAETIIKR---GGKIAVHCKAGLGRTGCLIGAHLI
|   . |. .  ... |||.|..        |....|.. |...|.. .|| . |.|| .  ..  ..  ...   |....|||||||||.|... | |.
kdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLm

YTYGFTANECIGFLRFIR-PGMVVGPQQHWL
|....||.| . ..|  | ||..  |.| .|
ykgkltadeAlelvrekRppgapnspsqerl
PTPc_motif_SM00404 191-332 2e-25 84.3 In-house 2-137 (140) alignment 
Range on Protein: 191-332
Range on HMM: 2-137/140.0
PQEDHPKGYLATKSSHLNQPFKSVLNFFANNNVQLVVRLNshlYNKKHFEDIGIQhLDLIFEDGTCPDLSIVKNFVGAAetiIKRGGKIAVHCKAGLGRT
|.. .|. ||..||.. |..... |.. .  ||. .|.|.   .....|. . |. ||   .| ....|. |..|. .|   .|.|||. |||.||. |.
psrilphlylgskskaqnpallkklgithvinvteevslt...kensgfqilqip.lddnekdklskyldkvldfiena...ekkggkvlVHCqaGvSRS

GCLIGAHLIYTYGFTANECIGFLRFIRPGMVVG-PQQHWLYLH
..|| |.|.........|.. |..  || .       ..|. .
atliiaYlmryrqlslaeayefvkerRpiispnlnfvrqLiey
0047943 (Phosphotyrosine protein) phosphatases II 194-328 1e-23 79.6 In-house 74-262 (273) alignment 
Range on Protein: 194-328
Range on HMM: 74-262/273.0
DHPKGYLATKSSHLNqPFKSVLNFFANNNVQLVVRLNSHLYN----------------KKHFEDIGIQHLDL----------------------------
.... ..||.    |  ... .... ..||...|.|..  ..                .. .... . .|.                             
nlkrkfiatqgPlpn.tvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfh

---IFEDGTCPDLSIVKNFVGAAETIIK---RGGKIAVHCKAGLGRTGCLIGAHLI-----YTYGFTANECIGFLRFIRPGMVVGPQQHW
   . ..|..|.|... .|. .......   ..|...|||.||.||||..| ..|.     ...|... |.. .||  |||||  |.|  
ytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyr
0046845 (Phosphotyrosine protein) phosphatases II 214-328 1.7e-19 65.8 In-house 93-264 (284) alignment 
Range on Protein: 214-328
Range on HMM: 93-264/284.0
VLNFFANNNVQLVVRLNSHL-----------------------------------------------YNKKHFEDIGIQHLDLIfEDGTCPDLSIVKNFV
  .   ..||...| |..                                                 |...... . .....   ..|..|..... .|.
FwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswp.dhgvppspedllefl

GAAETIIKR---GGKIAVHCKAGLGRTGCLIGAHLIYTY--------GFTANECIGFLRFIRPGMVVGPQQHW
 ........   ||.|.|||.||.||||..| ..|....        |... |.. .||  |||||  ..|  
rlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyr
0051299 (Phosphotyrosine protein) phosphatases II 217-328 8.1e-18 60.3 In-house 111-276 (288) alignment 
Range on Protein: 217-328
Range on HMM: 111-276/288.0
FFANNNVQLVVRLNSHL--------------------------YNKKHFEDIGIQHLDLIF----------------------EDGTCPDLSIVKNFVGA
   ..||...|.|..                             . ....|. . .| .                        ..|. .... . .|. .
mvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrl

AETII-KRGGKIAVHCKAGLGRTGCLIGAHLI-----YTYGFTANECIGFLRFIRPGMVVGPQQHW
. . . ..|| ..|||.||.||||..| . |.     ...|... | . .||  |||||  |.| .
vrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyr
subfamily_PRL_pd Subfamily PRL 214-330 1.4e-17 58.1 In-house 26-143 (151) alignment 
Range on Protein: 214-330
Range on HMM: 26-143/151.0
VLNFFANNNVQLVVRLNSHLYNKKHFEDIGIQHLDLIFEDGTCPDLSIVKNFVGAAETIIKRG--GKIAVHCKAGLGRTGCLIGAHLIYtYGFTANECIG
  . . ...|. |||     |.....|. ||. ||| |.||. |  ..|....   ..  |.     .|||| |||||.  |.   ||   |.. .. . 
fieelkkeevktvvrvceptydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalalie.aGmkyedave

FLRFIRPGMVVGPQQHWLY
|.|  | | .   | ..| 
firekrrgainskqlkfle
subfamily_PTPDC1_pd Subfamily PTPDC1 182-323 1.9e-17 58.3 In-house 19-161 (182) alignment 
Range on Protein: 182-323
Range on HMM: 19-161/182.0
TPDFIAFASPQEDHPKGYLATKSsHLNQPFKSVLNFFANN---NVQLVVRLNSHLYNKKHFEDIGIQHLDLIFEDGTCPDLSIVKNFVGAAETIIKRGgK
| | .|.|.|.... . |   .    ..  |.|.|.  .    .    .. .   |..... . || .  . ..|   . |  . . |  ..  ...| |
tedilalarpsqeaideyklldk.fkesgikavinLqekgehasCGagleesGfsYdlealmeqgiyvynfgwkDygvasleriLdivkvvafalqeg.k

IAVHCKAGLGRTGCLIGAHLIYTYGFTANECIGFLRFIRPGMVVG
.|||| ||||||| || ..|.|.  .||.. | ..|  ||  .  
vavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqt
0051429 (Phosphotyrosine protein) phosphatases II 217-330 1e-16 56.9 In-house 40-217 (272) alignment 
Range on Protein: 217-330
Range on HMM: 40-217/272.0
FFANNNVQLVVRLNSHL---YNKKHFEDIGIQHLDLIFEDGTCPDL----------------------------------------------------SI
.......  .| | |     ..| ...  ||..| | ..| . |.                                                     . 
rlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqea

VKNFVGAAETiikrGGKIAVHCKAGLGRTGCLIGAHLIYtYGFT--------------ANECIGFLRFIRPGMVVGPQQHWLY
..... .  .    ||.. |||.|| .|||... . |.. .|..              . |..  || .|||.|  ..| .  
llellellld....ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylfl
0036941 (Phosphotyrosine protein) phosphatases II 218-328 1.2e-16 56.3 In-house 95-268 (297) alignment 
Range on Protein: 218-328
Range on HMM: 95-268/297.0
FA---NNNVQLVVRLNSHLYNKK---------------HFEDIGIQHLDLIF--------------------------------EDGTCPD-LSIVKNFV
.    ..||. .| |..   . .                ..|. .. |.                                    |  .|.  ... .|.
WrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfi

GAAETIIK---RGGKIAVHCKAGLGRTGCLIGAHLI--------YTYGFTANECIGFLRFIRPGMVVGPQQH-W
 ......|   .||.. |||.||.||.|..|.| |.        ...|..  |.. .||  |||.|  ..|  .
elvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrf
subfamily_PTPMT1_pd Subfamily PTPMT1 210-330 1.6e-13 45.5 In-house 33-160 (171) alignment 
Range on Protein: 210-330
Range on HMM: 33-160/171.0
PFKSVLN-FFANNNVQLVVRLNSHLY------NKKHFEDIGIQHLDLIFEDGT-CPDLSIVKNFVGAAETIIKRGGKIAVHCKAGLGRTGCLIGAHLIYT
||.|  .  . ..||. || ||.         ......  |...| |   | |  |||  ... |   | ....| .. |||||| ||.. |....|...
PfrslikeLiekenvkavvslneeyelkalansteewkklgveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkk

YGFTANECIGFLRFIRPGMVVGPQQhWLY
. .. .| . .|. .|. . .  .| |  
eklspeeAlkalkkkRkiirlakkq.wka
subfamily_DSP23_pd Subfamily DSP23 216-328 2.6e-11 38.4 In-house 25-136 (148) alignment 
Range on Protein: 216-328
Range on HMM: 25-136/148.0
NFFANNNVQLVVRLNSHLYNKKHfEDIGIQHLDLIFEDGTCPDLSIVKNFVGAAETIIKRGGKIAVHCKAGLGRTGCLIGAHLIYTYGFTANECIGFLRF
...... |. .| |  .   . .    ..    |  .| . | |  |..||   |   ...  ..|||  | |||| ..  .|.   ...| | |  .| 
rylldlgvrylvslteegrphve.atpnltlvrlriddyhppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrr

IRPGMVVGPQQHW
 ||| |   .|  
lrpgsvetveqek
subfamily_DSP11_pd Subfamily DSP11 185-314 4e-11 37.1 In-house 20-154 (178) alignment 
Range on Protein: 185-314
Range on HMM: 20-154/178.0
FIAFASPQEDHPKGYLATKSSHLNQPFKSVLNFfANNNVQLVVRLN--SHLYNKKHFEDIGIQHLDLIFEDGTCPDLSIVKNFVGAAETIIK----RGGK
||||  | ... .  ....     . . . |.  .|... ||. |      |.||...| |...| |     . |.  .||.|  | .  ..     .  
fiafktPlkesfdkkveeekrftpkdLleklqe.knkklGLvidltntdryykkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkl

IAVHCKAGLGRTGCLIGAHLIYTYGFTANECIGFLR
|.|||  |. ||| ||  .|| . |. ... |  . 
igvhCthGvnrtGyliCrylidvegyepedaieafe
subfamily_PTEN_pd Subfamily PTEN 214-307 5.7e-11 37.7 In-house 53-145 (184) alignment 
Range on Protein: 214-307
Range on HMM: 53-145/184.0
VLNFFANNNVQLVVRLNSHLYNKKHFEDiGIQHLDliFEDGTCPDLSIVKNFVGAAETIIKRGGK--IAVHCKAGLGRTGCLIGAHLIYTYGFTAN
.|.   ......      . |..|.|..  .....  |.| . | |......|  .|. ...  |  ..|||||| |||| || |.|...  .. .
flekkhkdhykiynlrserkydskkfdg.rvavyp..fdDhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllksllleka
subfamily_RNGTT_pd Subfamily RNGTT 211-318 9.9e-11 35.7 In-house 44-155 (189) alignment 
Range on Protein: 211-318
Range on HMM: 44-155/189.0
FKSVLNFFaNNNVQLVVRLN--SHLYNKKHFEDIGIQHLDLIFE-DGTCPDLSIVKNFVGAAETIIKR--GGKIAVHCKAGLGRTGCLIGAHLIYTYGFT
 .| |.   .... ||. |   |  |.|...|. ||..  |  .  | .|.   ||.|    |. .|.     |.|||. |  ||| || ..|. .  . 
llsylktl.kvklglvidltntsryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedws

ANECIGFLRFIRP
... .   .  ||
veaavalFakaRp
subfamily_DSP1_pd Subfamily DSP1 215-318 9.9e-09 29.5 In-house 36-137 (163) alignment 
Range on Protein: 215-318
Range on HMM: 36-137/163.0
LNFFANNNVQLVVRLNSHlyNKKHFEDiGIQHLDLIFEDGTCPDLSIV-KNFVGAAETIIKRGGKIAVHCKAGLGRTGCLIGAHLIYTYGFTANECIGFL
|.. .....  .. . ..   ...|||   ..  |  || .  |.| | .. .   ....| .||. .||.||. |  .|. |.|. |  .. .|   | 
leiLkslgitailnvske..ldnvfed.lfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlclaylmktkrvsleeafdfv

RFIRP
.  |.
kqrRs
subfamily_VSP_pd Subfamily VSP 205-314 9e-08 26.3 In-house 55-167 (212) alignment 
Range on Protein: 205-314
Range on HMM: 55-167/212.0
SHLNQPFKSVLNFFAN--NNVQLVVRLNS-HLYNKKHFEDigiQHLDLIFEDGTCPDLSIVKNFVGAAETIIKRGGK--IAVHCKAGLGRTGCLIGAHLI
|   .| . |  |. .  ..   || | |   |..|.|..   .   .  .|   | |. . .|   ..  ...  |  .|.||| | |||| .. |.|.
slyrnpisevarfldtkhrdhykvvnlcseraydekyfnn...rvkriliddhnvpkleellvftkevkewlekdlknvlaihckGGkgrtGtivcalll

YTYGF-TANECIGFLR
..  | ||.|.. .. 
aseifetakesldyfg
PTPc_DSPc_SM00012 267-321 1.7e-07 26.7 In-house 34-90 (105) alignment 
Range on Protein: 267-321
Range on HMM: 34-90/105.0
GAAETiikrGGKIAVHCKAGLGRTGCLIGAHLIYTYGFT------ANECIGFLRFIRPGMV
 ..|.    .. . |||.|| ||||... . ...    .        ...  ||  |||||
nkses....skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmv
subfamily_DSP3_pd Subfamily DSP3 235-315 5.1e-07 23.5 In-house 54-136 (162) alignment 
Range on Protein: 235-315
Range on HMM: 54-136/162.0
NKKHFEDIGIQHLDLIFEDGTCPDLSivKNFVGAA----ETIIKRGGKIAVHCKAGLGRTGCLIGAHLIYTYGFTANECIGFLRF
......|..|..| |  .|    |||  | |  ||    |.. .. ||. |||..|. |   |. |.|. .  .|..| |   | 
gaefykdleikylGlevdDvpefdls..kyFetaakfidealsqkegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrk
subfamily_STYX_pd Subfamily STYX 261-312 1.7e-06 21.2 In-house 84-132 (166) alignment 
Range on Protein: 261-312
Range on HMM: 84-132/166.0
IVKNFVgaaETIIKRGGKIAVHCKAGLGRTGCLIGAHLIYTYGFTANECIGF
 ||.|.   .. ...|||. || .||. |. .|. |... |||.   |.  .
tvkefi...ddslqkggkvlvhgnagisrsaalviayimetyglkyreafay
subfamily_DSP12_pd Subfamily DSP12 270-318 4.3e-06 21.2 In-house 76-124 (155) alignment 
Range on Protein: 270-318
Range on HMM: 76-124/155.0
ETIIKRGGKIAVHCKAGLGRTGCLIGAHLIYTYGFTANECIGFLRFIRP
|  ....|.. |||.||. |   .. |.|......  .. . ... ..|
eealeeegavlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkp
CDKN3 Cyclin-dependent kinase inhibitor 3 (CDKN3) 241-300 4.5e-06 17.9 Pfam-A 98-156 (168) alignment 
Range on Protein: 241-300
Range on HMM: 98-156/168.0
DIGIQHLDLIFEDGTCPDLSIVKNFVGAAETIIKRGGKIAVHCKAGLGRTgCLIGAHLIY
..||        ||  ||.. . . .    | .|   |  .||  ||||. ||. | |. 
qygivthhhpiadggtpdiascleimeelatclknyrktlihcygglgrs.clvaaclll
CDKN3 Cyclin-dependent kinase inhibitor 3 (CDKN3) 241-300 4.5e-06 17.9 In-house 98-156 (168) alignment 
Range on Protein: 241-300
Range on HMM: 98-156/168.0
DIGIQHLDLIFEDGTCPDLSIVKNFVGAAETIIKRGGKIAVHCKAGLGRTgCLIGAHLIY
..||        ||  ||.. . . .    | .|   |  .||  ||||. ||. | |. 
qygivthhhpiadggtpdiascleimeelatclknyrktlihcygglgrs.clvaaclll
subfamily_DSP19_pd Subfamily DSP19 237-319 7e-06 20.5 In-house 54-132 (152) alignment 
Range on Protein: 237-319
Range on HMM: 54-132/152.0
KHFEDIGIQHLDLIfEDGTCPDLSIVKNFVGAAEtiiKRGGKIAVHCKAGLGRTGCLIGAHLIYTYGFTANECIGFLRFIRPG
|.|.   |. |||  |   .  |. . .|.  |    .  | . |||.||  |.  .. |.|. .   . .|..  .| .|| 
kdftylsieilDlp.etdllsylkealdFieear...skdgavlvHCnAGvSRsasvviaylmkkeelsleealelvrearpc
DSPc_SM00195 272-326 8.8e-06 20.6 In-house 194-250 (263) alignment 
Range on Protein: 272-326
Range on HMM: 194-250/263.0
IikrGGKIAVHCKAGLGRTGCLIGAHLIYT-----YGFTANECIGFLRFIRPGMVVGPQQ
.    | | |||.||.||||... ...|.        .   |..  ||  |||||   .|
s...sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleq
PTPc_SM00194 272-326 8.8e-06 20.6 In-house 194-250 (263) alignment 
Range on Protein: 272-326
Range on HMM: 194-250/263.0
IikrGGKIAVHCKAGLGRTGCLIGAHLIYT-----YGFTANECIGFLRFIRPGMVVGPQQ
.    | | |||.||.||||... ...|.        .   |..  ||  |||||   .|
s...sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleq