Gene PHO12 in Saccharomyces cerevisiae

Synonym: PHO10, YHR215W, PHO12

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP2
Subfamily MINPP1
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP032_AA protein Get Run
ScerP032_AA_31-459 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_MINPP1_pd Subfamily MINPP1 36-443 5.3e-155 508.4 In-house 1-419 (420) alignment 
Range on Protein: 36-443
Range on HMM: 1-419/420.0
EIFPFLGGSGPYYSFPGDYGISRDLPESCEMKQVQMVGRHGERYPTVSKAKSIMTTWYKLSNYTGQFSGALSFLNDDYEffirdtKNLEMETTLANSVNV
|...|||...||||....|.|.....|.|.....|...|||.|||..||.|.|..|..|..||..|..|.||.||.|.|      .|||.||.|..|...
elvkflgsktpyysvkanydikkeaeegCklvklqiiaRHGtRypskskikkiqetlekiknyseqldgklsilnedle......snleyetelekslva

LNPYTGEMNAKRHARDFLAQYGyMVENQTSFAVFTSNSNRCHDTAQYFIDGL-------GDKFNISLQTISEAESagANTLSAHHSCPAWDDDVNDDILK
 .....|..|||.||.|.|... .|.|..||........|....||.|..||       ||.|||.||.|||.||  ...|....||......|....|.
qgqeeleelakrlarrfpalfe.evynpdsfsfastakkRtvksaqaFaeGLsetgevlgdefnivlqeiseqes..dklLrffdsCkkyknkvkkneln

KYDT----------KYLSGIAKRLNKENKGLNLTSSDANTFFAWCAYEINARGYSDI-CNIFTKDELVRFSYGQDLETYYQTGPGYDVVRSVGANLFNAS
....          |.|. ||||||.|.|.|.||..|....|..||||....|.|.. |..|.||||....| .||..||..|.||....|....|.|. 
lkeeeefleskelqkaleeiakrlneekklleltekdiedmfeiCayelaikgisnvWcslfekdelleleYledLknyykegyGyeinysiscpLlndi

VKLLKESEVQDQKVW-LSFTHDTDILNYLTTIGIIDDQNNLTA-EHVPFMENTFHRSWYVPQGARVYTEKFQCSNDTY-VRYVINDAVVPIETCSTGPGF
|||||.|| |.||.. |.|.|....|..|...|...|...||| .........|..|..||..|........||.|.| |....|..||..||||.|..|
vkllksseeqkqkssslrFaHaetllpllsllGlykDeekLtannyhklsnrkfrssvivpyaanlafvlydCskdqykvlvllnekvvkletcsegeif

sCEINDFYGYAEKRVAGTDFLKVCNVSSV
 ||..||. ...|.|...|. |.|.||.|
.CelqdfkeiykkivdncdleklCevskv
0048946 Phosphoglycerate mutase-like 33-459 3.2e-92 302.7 In-house 9-429 (447) alignment 
Range on Protein: 33-459
Range on HMM: 9-429/447.0
TQTEIFPFLGGSGPYYSFPGdYGISRDLPESCEMKQVQMVGRHGERYPTVSKAKSIMTTWYKLSNYTGQ-FSGALSFLNDDyEFFIRDTKNLEmettlaN
....|...||.. ||.|.|| |||. ..||.|| ||||.. |||.|.|| .  |... ....| |...  ..| ||||||. . ....    .       
dgfnillhlgtlspyfsvpg.ygipepvpegcelkqvqvlfRHGaRtPtkkylkgleplldllknanvlelggdlsflndw.kyqlkneplwp......c

SVNVLNpYTGEMNAKRHARDFLAQYGYMVENQTSFAVFTSNSNRCHDTAQYFIDGLGDKF---NISLQTISEAESAGANTLSAhhSCPAWDDDVNDDILk
  . |  ..|   .  . . .   |.    |.. . |..|...|....||.|. || ..    .. . .| ...| . |.|    ||||....... .  
glgqLT.plGreqlyelGkrlrkrYlgllpnpseiyvrssdvdRtlqSaqaflaGlfppepplgyqpipihtvpssndnlllp..sCpafkellkkela.

KYDTKYLSGIAKRLNKENKGLNLTSSDANTFFAWCAYEINARGYSDICNIFTKDELVRFSYGQDLETYYQTGPGYDVVRSVGANLFNASVKLLKESEVQD
..  ..|. ...||.| ..||||| ||..... ...|| ...|.|. |..||..|| .. | .||| || .|.|... | .|  |.|. .. |..  ..|
eelkellkellerlkkllgglnltlsdvydlydlllyetaihglsplcslftpeelevleyladlefyyeygygdelarlaggpllneilarledaisgd

QKVWLSFTHDTDILNYLTTIGIIDDQNNLTAEHVPFmENTFHRSWYVPQGARVYTEKFQC------SNDTYVRYVINDAVVPIETCSTGPGFSCEINDFY
.|..|.|.|||.|.. |...|. ||.  |.|...|| ...|. |..|| ......|...|      ....|||...|....|.. |..|||..|. .|| 
sklylyfaHdttiaallsaLglfddelplpadnlpf.nrlfrsseivPyasnlvfElyecpsslpsdgeyyVrvlyngeplplpgCgsgpgglCplddFk

GYAEKRVAgtDFLKVCNVsSVSNSTELTFFWDWNTKH
 . .|..   |. |.|.. . |. ..|....|... .
ellkkflp..dweklCgl.tlsvlallsvlidvlllt
0049059 Phosphoglycerate mutase-like 33-439 1.5e-85 280.7 In-house 10-435 (435) alignment 
Range on Protein: 33-439
Range on HMM: 10-435/435.0
TQTEIFPFLGGSGPYYSFPGDYGISRDLPESCEMKQVQMVGRHGERYPTVSKAKSIMTTWYKLSNYTGQFSGALSFLNDdYEFFIRdtknlemettlans
....|. .||. .||.|.|| .||| |.||.|| ||||.. |||.|.|| .  |.. ..| || ...  ..| |||||| .....               
dgfnillllgtlspyfsapgvfgisldvpegcelkqvqvlfRHGaRtPtsklikklealwekllslltypngplsflnd.wnyplg..............

VNVLNPyTGEMNAKRHARDFLAQYGYMvENQTSFAVFTSNSNRCHDTAQYFIDGLGDKF----------NISLQTISEAESAGANTLsAHHSCPAWDDDV
 . | | .|   |..... . . || .  |.. . |..|...|. ..||.|. || .            |. .... |. ... .||  . ||||.|. .
ageLTp.lGreqayelGkrlrkrYgfL.ynpdevyvrssdvdRtlqSaqaflaGlfppeilgsqllnplnvyqpvpietvdsdndtl.pydscpafdell

NDDIL-KKYDTKYLSGIAKRLNKENKGLNLTSSDANTFFAWCAYEINARGY-----SDICNIFTKDELVRFSYGQDLETYYQTGPGYDVVRSVGANLFNA
....  ... . .|. |.|.|.. ..||.|| || ......|.|.. ..||     .. |..||..|| ...| .|||.||. |.|... . .|  |.|.
kellasdeflelflerilkllqellpglgltpsdvldlydlckydtlllgyahglplpfcslfteeelevleyladlefyylygygdeiaklaggpllne

SVKLLKESEVQ------------------DQKVWLSFTHDTDILNYLTTIGIIDDQNNLTAEHVPFM--ENTFHRSWYVPQGARVYTEKFQCSN--DTYV
 .. |..  ..                  |.|..|.|.|||.|.. |...|. |||  |.|...||.  ...|. |..|| ......|...|..  ..||
ilarledaingdstnlnltldsnpatfpldlklylyfaHdttiapllsaLglfddqlplpadntpfpeldrlfrtseivPyasnlvfElyecpdgneyyV

RYVINDAVVPIETCSTGPGFSCEINDFYGYAEKRVAGTDFLKvCN
|...|..|.|.. |..|||..|. .||  . .|.. | || . |.
rvlyngkvlplpgcgsgpgglCplddFkelvkkflpgddfde.Cg
0047369 Phosphoglycerate mutase-like 32-440 2.9e-84 276.6 In-house 10-438 (438) alignment 
Range on Protein: 32-440
Range on HMM: 10-438/438.0
GTQTEIFPFLGGSGPYYSFPGDYGISRDLPESCEMKQVQMVGRHGERYPTVSKAKSIMTTWYKLSNYTGQFSGALSFLNDdYEFFIRDtknlEMETTlan
 ... |...||.  ||.|.||   || |.||.|| ||||.. |||.|.|| || | .. .| .| |.|. .|| |||||| . ...      .. |.   
svdfnillhlgtlspyfsapgvglisldvpegcelkqvqvlfRHGaRtPtksklkkleplwellenattypsgplsflnd.wlgpcga....gqLTp...

svnvlnpyTGEMNAKRHARDFLAQYGYMveNQTSF-AVFTSNSNRCHDTAQYFIDGLG-DKF----------NISLQTISEAESAGANTLsAHHSCPAWD
        .|   |. . . . . ||..  |.  .  |..|...|....||.|. ||  . .          .| ..||.|. .   |.|  . ||||.|
........lGreqayelGkrlrkrYglL..npedvlyvrssdvdRtlqSAqaflaGlfppegtgelapilwqpipihtipesddfllnll.psdscpafd

DDVNDDIL-KKYDTKYLSGIAKRLNKENKGLNLTSSDANTFFAWCAYEINARGY-----SDICNIFTKDELVRFSYGQDLETYYQTGPGYDVVRSVGANL
. .....  ...  ..|. |.|||.| ..||||| ||..... .|||.. |.||     |. |..||..||  ..| .|||.|| .|.|... . .|  |
ellkeflasdeflelllkdilkrlkkllpglnltpsdvldlydlcaydtlangyaglplspfcslftpeelevleyladlefyylygygnelaklaggpl

FNASVKLLKESEVQ------------------DQKVWLSFTHDTDILNYLTTIGIIDDQNNLTAEH--VPFMENTFHRSWYVPQGARVYTEKFQCS--ND
.|. .. |..  .                   |.|..|.|.|||.|...|...|. ||.  |.      ......|. |..|| ......|...|.  ..
lneilarledaingkstnlnltldsngvtfPldlklylyfaHdttiaallsaLglfddtwplpglpldkialnrlfrsseivPyasnlvfElyecpsdge

TYVRYVINDAVVPIETCSTGPGFSCEINDFYGYAEKRVAGtDFLKVCNV
.|||...|..|.|.. |..|||..|. .||. . .|.. | || ..|..
yyVrvlyngkvlplpgcgsgpgglCplddFkelvkkllpg.dfeelCgl
0046349 Phosphoglycerate mutase-like 60-455 3e-67 220.5 In-house 2-407 (409) alignment 
Range on Protein: 60-455
Range on HMM: 2-407/409.0
LPeSCEMKQVQMVGRHGERYPTVSkaksimttwyklsnytgqfsgaLSFLNDDYEFFIRdtknlemetTLANSVNVLNpYTGEMNAKRHARDFLAQY--G
.| .||.||||.. |||.|.||..                      ||||... .. .          .       |  ..|   | .. . . . |  .
vP.gceLkqvqvlfRHGaRtPtkk......................lsflpnwpginwt.........ngpcgagqLT.plGreqayelGkrlrkrYvdl

YMVENQ-----TSFAVFTSNSNRCHDTAQYFIDGLG-D-------------------KFNISLQTISEAESAGANTLSAHHSCPAWDDDVN------DDI
 .. ..     . . |..|...|. ..||.|. ||  .                   ...|....|||... ... |  ...|||.|....      ...
gLlpsnslynpdeiyvrssdvdRtlqSAqaflaGlfpplggeivpllrqdlldppfqpipidtvpiseddalddtllppdslcpaldkllkenlkslsev

LK-----------KYDT--KYLSGIAKRLNKENKGLNLT-SSDANT-FFAWCAYEINA-RGYSDICNIFTKDELVRFSYGQDLETYYQTGPGyDVVRSVG
|.           ..|.   .|. .|.|||.|..|||||  .|.   .. ...||.   ..... |..||..|| ...| .||| ||..|.| .. . .|
leflvdealldlelldetkdllkklaerlnselpglnltdpldvasllydtllyetahglplppwcdlftpeelkvlayladleyyylygsg.elaklag

ANLFNASVKLLKESEVQ--------DQKVWLSFTHDTDILNYLTTIGIiddqnnltaehvpfMENTFHRSWYVPQGARVYTEKFQC--SNDTYVRYVIND
  |.|. .. |..  ..        |.|..|.|.|||.|...|...|.               ...|. |...| ......|...|  ....|||...|.
gpllneilarledaisgknpvtfpldlklylyfaHdttiaallsaLgl..............fdrlfrssdippyasnlvfElyecpsdgeyyVrvlyng

AVVPIETCSTGpgfsCEINDFYGYAEKRVAGT---DFLKVCNVSSVSNSTELTFFWDW
...|.  |..|    |. ..|. . .||. |.   || |.|....  .  . ....|.
gplplpgcgeg....cplsefkellkkrlpgcgltdfdklCpledflrfvdkailsdl
0048439 Phosphoglycerate mutase-like 59-429 9.3e-66 215.7 In-house 2-390 (391) alignment 
Range on Protein: 59-429
Range on HMM: 2-390/391.0
DLPESCEMKQVQMVGRHGERYPTVSKAKSIMTTWYKlsnytgqfsgalsflnddyeffirdtknlemettlansV--------NVLNPYtGEMNAKRHAR
|.|..|| ||||.. |||.|.||.|  . .  ...|                                      .        . | |. |   .  . |
dvpagcelkqvqvlfRHGaRtPtssypnkldpllnk......................................llpngpcglgeLTpl.GreqlyelGr

DFLAQY--GYMVE-----NQTSFAVFTSNSNRCHDTAQYFIDGL--GDKFNISLQTISEAESAGANTLsAHHSCPAWDDDVNDDILKKYDTKYLSGIAKR
 . . |  . ..      |.. . |..|...|. ..||.|. ||  . .... |. ..| |. ..| | ....||...|. ..|.|. ..  ||| | .|
rlrkrYvdlgllpskytlnpsevyvrssdvdRtlqSAqaflaGlfpplgltvilvivvesedpllnpl.pintcplledlllldalsalprfylseiler

LNKEN---KGLNLTSSDANTFFAWCAYEINARGY-----SDICNIFTKDELVRFSYGQDLE-------------------------TYYQTGPGyDVVRS
|....   .||||| .|  ..| .||.|..|.|.     |..|..||  . . . | ..|.                          ||.||.| .. . 
laevlnrvlglnltaedvlslfdlcaketaalgsllklssplcdlftlydtllyeyahglplpewltdellspellkqladlvnelyyyltgsg.eiakl

VGANLFNASVKLLKESEVQDQKVWLSFTHDTDILNYLTTIGIIDDQNNLTAEHvpfmentfhrswyVPQGARVYTEKFQC--SNDTYVRYVINDA-----
.|  |.|. .. |. .  .|.|..| |.|||.|.. |...|. .|.  |.| .             .| ......|...|  ....||| ..|..     
aggpllneilddlvangpsdpklylyfaHdttiaallsaLglfndtlplpadl.............ppyasnlvfElyecpsdgeyyVrvlynggtldlp

---------------VVPIETCSTGPGFSCEINDFYGYAEKRV
               |.|.  |..|||..|...||. . .||.
rdltlldldefllrlvlplpgcgsgpgglCplddFvelvkkri
0053031 Phosphoglycerate mutase-like 65-438 1.2e-58 192.1 In-house 2-340 (342) alignment 
Range on Protein: 65-438
Range on HMM: 2-340/342.0
EMKQVQMVGRHGERYPTVSKAKSIMTTWYKlsnytgqfsgalsflnddyeffirdtknlemettlansvnvlnP-------YTGEMNAKRHARDFLAQYG
|.|||... |||.|.|...  ..   .|.                                            |       ..|   |. . | .   |.
eLkqvivlvRHGaRtPlskgpldplnewfy...........................................pcgageLTplGreqayelGrrlrkrYl

YMVE---NQTSFAVFTSNSNRCHDTAQYFIDGL--GDKFNIS--------LQTISEAESAGANTLSAHHSCPAWDDDVNDDILKKYDTKYLSGIAKRLNK
  .    |.. . |..|...|. ..||.|. ||  .....|         .. ..|.|| .|. |  ...|||.|. .....  ..  ..|. ....|.|
gllpstynpdevyvrssdvdRtlqSAqaflaGlfppegtpilnpllgwqpipihtepessdalllpnydpcpafdkllkealaseevkellerylellqk

ENKGLNLTSSD----ANTFFAWCAYEINA-RGYSDICNIFTKDELVRFsYGQDLETYYQTGPGYDVVRSVGANLFNASVKLLKESE--VQDQKVWLSFTH
 .|||.|| ||    ..... ...||.   ..... |..|| .|| .. | .||  ||..|||... . .|  |.|. .. |.|      |.|..| |.|
lskglgltlsdlldlvsdlydlllyelahglplppwctlftleelkal.yaldllyyyglgpgnelaklaggpllneilarleekisgpldlklylyfah

DTDILNYLTTIGIIddqnnltAEHVPfmentfhrswyvPQGARVYTEKFQCSNDTYVRYVINDA------VVPIETCstgPGfSCEINDFYGYAEKRVAG
||.|...|...|.         .. |            | ......|........|||...|..      |.|.  |   .| .|....|. . .|.. |
dttiaallsaLglf.......ddqlP............pyasnlvfElyedpgeyyVrvlynggtlseplvlplpgc...dg.lcplsefkelvkkllpg

tDFLKVC
 || |.|
.dfeklC
0049226 Phosphoglycerate mutase-like 65-438 6.2e-57 186.3 In-house 2-340 (342) alignment 
Range on Protein: 65-438
Range on HMM: 2-340/342.0
EMKQVQMVGRHGERYPTVSKAKSIMTTWYklsnytgqfsgalsflnddyeffirdtknlemettlansvnvlNP-------YTGEMNAKRHARDFLAQYG
..||||.. |||.|.|...  ..    |.                                            .       ..|   |  ..| .   |.
kLkqvqvliRHGdRtPlakgpldflnewf...........................................wgcglgeLTplGreqayelGrrlrkrYl

YMVENQ---TSFAVFTSNSNRCHDTAQYFIDGLGDKFNIS----------LQTISEAESAGANTLSAHHSCPAWDDDVNDDILKKYDTKYLSGIAKRLNK
  . .    . . |..|...|. ..||.|. || .  ...          ...|.| || ... |  . |||..|. ... .  ..  ..|. |...|.|
gllpstynpdevyvrssdvdRtlqSaqaflaGlfppeltpilvplldwqpipiitepesndtllllpydscpnfdkllkellkseevqlfleeildllkk

ENK--GLNL-TSSDANT-FFAWCAYEINAR-GYSDICNIFTKDELVRFsYGQDLETYYQTGPGYDVVRSVGANLFNASVKLLKESE--VQDQKVWLSFTH
  |  |||| |.||.   .. ...||.. . .... |..|| .||  . | .||  || .|.|... | .|  |.|. .. |.|      |.|..|.|.|
lskllglnlstlsdvadtlydlllyelahglplppwcslftleelkal.yaldllyyygigygeeiarlaggpllneilarleeaiegpsdlklylyfah

DTDILNYLTTIGIIDdqnnltaEHVPfmentfhrswyvPQGARVYTEKFQCSNDTYVRYVINDAV------VPIETCstgPGFsCEINDFYGYAEKRVAG
||.|...|...|. |       ...|            | ......|...|....|||...|..|      .|.  |   .|. |....|. . .|.. |
dttiaallsalglfd.......dqlP............pyasnlvfElyecdgeyyVrvlynggvlslpvtlplpgc...dgl.cpldefkelvkkflpg

tDFLKVC
 || ..|
.dfeelC
His_Phos_2 Histidine phosphatase superfamily (branch 2) 65-399 5.6e-53 173.0 Pfam-A 1-347 (347) alignment 
Range on Protein: 65-399
Range on HMM: 1-347/347.0
EMKQVQMVGRHGERYPTVSKAKSIMTTWYKLSN-YTGQFSGALSFLNDDYEffirdtknleMETTLANSVNVLNPYtGEMNAKRHARDFLAQYGYMVENQ
|.|.|..| |||.|.|. ...||.  .. .    ..... . ..|...  .           . .|      |... |...|. ... .  .|. .. ..
eLkgvvvviRHGdRtPkqkfkksvtsekfisllklknvlekkghfpgtkrk..........eklqlilkwgglThs.GrkqaeelGeqlrqrYpgllrdh

---TSFAVFTSNSNRCHDTAQYFIDGLGDKF---------------NISLQTISEAESAGANTLSAHH-SCPAWDD------DVNDDILKKYDTKYLSGI
     . ...|...|....||.|. || ..                |.  .|..|.... .. | . . ||||...      .  .. ..|.. ..   .
ltyedvkirssserRvlaSAqafaaGllgpegelllsirkdllddsnaakdtmdevkkklkellregaescpafawppikvekrvvelvnklkkvmdenl

AKRLNKENKG-LNLTSSDANTFFAWCAYEINARGYSDICNIFTK--DELVRFSYGQDLETYYQT-GPGYDVVRSVGANLFNASVKLLKESEVQDQ-----
||||..  .|  ||.  .  . . ....| . . .|.|......  ...  ... .|||..|.  |.|  . .  |  |.|. .| .... ...|     
akrlsalctgednllfkerweklfreffeeekfdiskipelydtmkydalhnrqledleelyklygigdeeklkigllllnpllkkilsdleetqpsrha

KVWLSFTHDTDILNYLTTIGIIDDQNNLtaehvpfmentfhRSWYVPQGARVYTEKFQCSND-TYVRYVIN
|..| ||||..|.. |...|. .... .             .|...| ......| ...|.. .|||....
klrlyfthDshiytllnaLgleekiare.............aspelpyasqivfelyedsekkfyvrllfs
His_Phos_2 Histidine phosphatase superfamily (branch 2) 65-399 5.6e-53 173.0 In-house 1-347 (347) alignment 
Range on Protein: 65-399
Range on HMM: 1-347/347.0
EMKQVQMVGRHGERYPTVSKAKSIMTTWYKLSN-YTGQFSGALSFLNDDYEffirdtknleMETTLANSVNVLNPYtGEMNAKRHARDFLAQYGYMVENQ
|.|.|..| |||.|.|. ...||.  .. .    ..... . ..|...  .           . .|      |... |...|. ... .  .|. .. ..
eLkgvvvviRHGdRtPkqkfkksvtsekfisllklknvlekkghfpgtkrk..........eklqlilkwgglThs.GrkqaeelGeqlrqrYpgllrdh

---TSFAVFTSNSNRCHDTAQYFIDGLGDKF---------------NISLQTISEAESAGANTLSAHH-SCPAWDD------DVNDDILKKYDTKYLSGI
     . ...|...|....||.|. || ..                |.  .|..|.... .. | . . ||||...      .  .. ..|.. ..   .
ltyedvkirssserRvlaSAqafaaGllgpegelllsirkdllddsnaakdtmdevkkklkellregaescpafawppikvekrvvelvnklkkvmdenl

AKRLNKENKG-LNLTSSDANTFFAWCAYEINARGYSDICNIFTK--DELVRFSYGQDLETYYQT-GPGYDVVRSVGANLFNASVKLLKESEVQDQ-----
||||..  .|  ||.  .  . . ....| . . .|.|......  ...  ... .|||..|.  |.|  . .  |  |.|. .| .... ...|     
akrlsalctgednllfkerweklfreffeeekfdiskipelydtmkydalhnrqledleelyklygigdeeklkigllllnpllkkilsdleetqpsrha

KVWLSFTHDTDILNYLTTIGIIDDQNNLtaehvpfmentfhRSWYVPQGARVYTEKFQCSND-TYVRYVIN
|..| ||||..|.. |...|. .... .             .|...| ......| ...|.. .|||....
klrlyfthDshiytllnaLgleekiare.............aspelpyasqivfelyedsekkfyvrllfs