Gene SAC1 in Saccharomyces cerevisiae

Synonym: RSD1, YKL212W, SAC1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Sac
Subfamily SAC1
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP042_AA protein Get Run
ScerP042_AA_181-502 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Sac_COG5329 2-620 6.8e-222 730.6 In-house 10-635 (1070) alignment 
Range on Protein: 2-620
Range on HMM: 10-635/1070.0
TGPIVYVQNADGIFFKLAegKGTNDAVIHLANQDQGVRVLGAEEFPVQGEVVKIASLMGFIKLKLNRYAIIANTVEET-GRFNGHVFYRVLQHSIVSTKF
|. |..|.|.....|. .  . .|......|.. ..|. | .|.|... .. .|....|.|.|. ... |........ ....|. .|..|.....|.. 
tRsiaivsnkyalvfrrl..svknselsvcaaelvavselkkegfrslssaheiygvlGlielegslflivitgkskvaqvipgetiykilavdfislnn

NSRIDSEE----AEYIK------LLEL--HLKNSTFYFSYTYDLTNSLQRNEKVGPAASWKTADERFFWNHYLTEDLRNFAHQDPRIDS-------FIQP
|.. |.|.    |.. |      ..||  .|.|..||||...|.||.||...| ....|..||||.|.||..|.|.| |..........       |...
nkwddeeiesdeasteklrsehpcselkkLlsngsFYfStdfditntLqkrlkeelelsvdtadeefmwnsflleelinyrsklsslekqlldnagFltt

VIYGYAKTVDAVLNATPIVLGLITRRSIFRAGTRYFRRGVDKDGNVGNFNETEQILLAEnpesekIHVFSFLQTRGSVPIYWAE-INNLKYKPNLVLG--
||.|.|.||.. .... |.| ||.|||. |||||...||||.||||.||.|||||. ..       ..|||.|.|||.||.|.. .|.| .... ...  
vIrGFaetvfikvkkktiaLtlISRrSskragtRflarGvDddGnvanFVETEqIvyss......qycfsFtQvRGSiPiFWeqesnsligpkiqitrss

ENSLDATKKHFDQQKELYGDNYLVNLVNQKGHELPVKEGYESVVHALNDPKIHYVYFDFHHECRKMQWHRVKLLIDHLEKLgLSNEDFFHKvidsNGNTV
|.. .|..||||.. | |||...|||...|..| ...|.||........||||...||||.|........||.|....|.  |.....|..    .... 
eatqsafdkHFdklfekYGdvhivNLlktKssEieLseryekhlklsekpkihlteFdfhketsqdgfddvkkLlplieqd.llefgyfsy....dvkeg

EIVNEQHSVVRTNCMDCLDRTNVVQSVLAQWVLQKEFESADVVATGSTWednaPLLTSYQNLWADNADAVSVAYSGTGALKTDFTRTGKRTRLGAFNDFL
....||..|.||||.||||||||.|......||...|.|..|.......    ..|.....|||||.||.| .|.||||||..|||.|||.. ||..|..
kliseQdGVfRtNClDCLDRTNviQqliskrvlleqfrsikvisaidde....dflqklneLWadnGDaisqiYTGtgalkssftrkgkrsiagalsDat

NSASRYYQNNWTDGPRQDSYDLFLGGFRPHTASIKSPF-PDRRPVYIQLIPMIICAALTVLGATIFFPKDRFTSSKNLLYFAGASIVLALSTKFMFKNGI
.|.||.|.||..|. .||..||.|| .....|.....   ........ ......|| .|. .|..| .....||..||... ...  ..|. ... .|.
kSvsRmyinnfvDkekQdaidllLgklpdqeavelydpineyvnlrlrkseseftaaknvsiftltfnsngessstkllklllkvlekkisklvvgvvgl

QFVNWPKLVDVGFLVVHQTHDKEQQFKGLKYAQSPKFSKPDPL
|...|..|.....|  ......|....  ||....|..| .  
qkqiwlelillssltksefkeeeeenlvrkyenklkkkkleqs
subfamily_SAC1_pd Subfamily SAC1 49-509 9.9e-217 711.0 In-house 1-457 (458) alignment 
Range on Protein: 49-509
Range on HMM: 1-457/458.0
QGEVVKIASLMGFIKLKLNRYAIIANTVEETGRFNGHVFYRVLQHSIVSTKFNSRIDSE-----EAEYIKLLELHLKNSTFYFSYTYDLTNSLQRNEKVG
..||||||...|.|||....|.|.....||.||.||.|.||| ...|...|.||....|     |.||.|||||.||..||||||||||||||||.|||.
aaevvkiagilGiikLlsgkylivitkkeevgringkviyrvadveiipvkknslslteeqkkeekeylkllelvlksetfYfsytydltnslqrlekvt

PAA-----SWKTADERFFWNHYLTEDLRNfahqDPRIDSFIQPVIYGYAKTVDAVLNATPIVLGLITRRSIFRAGTRYFRRGVDKDGNVGNFNETEQILL
.||     ....||||||||..|.||||.    .|...|||.|||.|..|.....|||..|.. ||.||||||||||||.|||||.|||.||.|||||..
saalkerslleradeRffwnkhlledlrk....epelesfilPvikGfikikelslnakeikfilisRRsifRaGtRyfvRGvdkeGnvanfvEtEqive

AEnpesekIHVFSFLQTRGSVPIYWAEINNLKYKP--NLVLGENSLDATKKHFDQQKELYGDNYLVNLVNQKGHELPVKEGYESVVHALNDPKIHYVYFD
||      ....||.|.|||.|..|....||||||  .|. .|.||||.|||.|.|.||||.|.|||||.|||.|....| |||||.|||..||.||.||
ae......kaltsFvqvRGsiPllWsqkpnLkykPkvklsesedsldafkkhldeqielygenvlvnLvdqkGsEkklgeayesvvralnkkkikyvafD

FHHECRKMQWHRVKLLIDHLEKlGLSNEDFFHKvidSNGNTveIVNEQHSVVRTNCMDCLDRTNVVQSVLAQWVLQKEFESADVVATGSTWEDNAPLLTS
||.|||||.|.|.|||||.|||  ||.|..|.|   |. ..  ||.||..||||||.|||||||||||.||..||||..||..|.||.|..||.|.|.||
FHkeCrkmrwdrlklLidqlek.elsqegyflk...seekk..ivkeqkgvvRtnCiDcLDRtnvvqsllarevLqkqleslgvlateskledsaelets

YQNLWADNADAVSVAYSGTGALKTDFTRTGKRTRLGAFNDFLNSASRYYQNNWTDGPRQDSYDLFLGGFRPHT
..||||||||||||.|.||||||||||||||||.|||..|..||.||||.||..||.||||.|||||..|..|
fknlwadnadavsvqYaGtgAlKtDftRtGkrtllGalrDgvnsvsryyknnfldgerqdsidLflgkyrvet
subfamily_INPP5F_pd Subfamily INPP5F 95-505 1.8e-109 358.3 In-house 109-506 (951) alignment 
Range on Protein: 95-505
Range on HMM: 109-506/951.0
IVSTKFNSRIDSEEAEYIKLLELHLKNSTFYFSYTYDLTNSLQRNEKVGPAASWKTADERFFWNHYLTEDLRNFAHQDPRIdsFIQPVIYGYAKTVDAVL
  ..| .   . .|   .. |.  |.. .||.|...||||.||....   . | .. |||||||..| .|| |  ... .   |. ||| |...|   . 
lkeekeqneeeklekrlleelkkllsdgsFYysldfDltntlqkrgleeksestddwderFfWNkfllkdlinyrdkldke..fltpviqGfvetkeisi

NATPIVLGLITRRSIFRAGTRYFRRGVDKDGNVGNFNETEQILLAENpesekiHVFSFLQTRGSVPIYWAEInNLKYKPNLVLGENSLD---ATKKHFDQ
.   ..| || ||| .|||||. |||.|.|||| || |||.|| .|.      .|.||.| |||||..| .  . ||||.. .  .. .   | ..||..
eklkvsltlisrrSrkragtrfkrrGidddgnvAnfvEtElilsvek......yvlsftqirGSvPvfweqs.gkkykpkikitrseeetqpaFdehfke

QKELYGDNYLVNLVNQKGHELPVKEGYESVVHALNDPKIHYVYFDFHHECRKMQWHRVKLLIDHLEKLGlsnEDFFHKVIDSNGntvEIVNEQHSVVRTN
| . ||    |||..||..|  . . |.  ...|..... .. ||||.|....... |. ||. ...      ..     |...   ... ||..|.|||
qlkkygkvvivnllsqkssekklskaykeqllkleskdvflikfdfheetsgekfenvsklieliknei...kevgyfsydvke...kviseqkgvfRtn

CMDCLDRTNVVQSVLAQWVLQKEFESADVVATGSTWEDnAPLLTSYQNLWADNADAVSVAYSGTGALKTDFTRTGKRTRLGAFNDFLNSASRYYQNNWTD
|.||||||||||. ... ||.   |  ...   |. .| . ||. ...||||| ||.|  | || ||| |.||.|.|   |. .|  .|.||||.||  |
clDcldrtNvvqqaiskavlelqleklglfepessidd.eellqklkklWadngdaisrqYagtnalkgdltrkgerklaGvlkdgyksvsryylnnfkd

GPRQDSYDLFLGGF
  ||.  || ||  
kyrqkvidlllGkl
Syja_N SacI homology domain 57-347 2e-88 287.6 Pfam-A 3-318 (319) alignment 
Range on Protein: 57-347
Range on HMM: 3-318/319.0
SLMGFIKLKLNRYAIIANTVEETGRFNG-HVFYRVLQHSIVSTKFNSRI-----------DSEEAEYIKLLELHLKNSTFYFSYTYDLTNSLQRNEKVGP
 ..|.|.|. . | ....  |......| |  |.. . ...... ...            ..||....|||.  |....|||||.||||.||||...   
gilGlirllsesyllvitkrekvakirgehpiykiksvefiplnseeeessaieeekeeeekeeekllkllkkllssgsfYfSydyDltrslqrksekee

---------AASWKTADERFFWNHYLTEDLRNFAhqdPRIDSFIQPVIYGYAKTVDAVLN-ATPIVLGLITRRSIFRAGTRYFRRGVDKDGNVGNFNETE
         .. .| .||||.||..|...| ..    .  .... |.|.|....    ..  . . | ||.|||. ||||||.|||.|.|||| ||.|||
eekeeeskslpllkevderFvWNrnllkplielk...ldlsrwllpliqGfveqrsievkskkkveltLIsRrsvkraGtRylrRGidddGnvANfvEtE

QILLAENpeSEKIHVFSFLQTRGSVPIYWAEINNLKYKPNLVLG---ENSLDATKKHFDQQKELYGDNYLVNLVNQKGHELPVKEGYESVVHAL-----N
||. ...  .|. .||||.|.|||||..| . .||..||. ..    |.| .|.||||..... ||. ..|||...||.| ...| ||. ...|     .
qivsekk..eeskrvfSfvqiRGSvPlfWeqasnlslkpkikitrsseasqkafkkHfkklikrYgkivvvnLlekkgrEkkLseayeelinklnkklke

DPKIHYVYFDFHHECRKMQWH
. |..|..||||.||......
kkklkyiefDfhkeckgkkfe
Syja_N SacI homology domain 57-347 2e-88 287.6 In-house 3-318 (319) alignment 
Range on Protein: 57-347
Range on HMM: 3-318/319.0
SLMGFIKLKLNRYAIIANTVEETGRFNG-HVFYRVLQHSIVSTKFNSRI-----------DSEEAEYIKLLELHLKNSTFYFSYTYDLTNSLQRNEKVGP
 ..|.|.|. . | ....  |......| |  |.. . ...... ...            ..||....|||.  |....|||||.||||.||||...   
gilGlirllsesyllvitkrekvakirgehpiykiksvefiplnseeeessaieeekeeeekeeekllkllkkllssgsfYfSydyDltrslqrksekee

---------AASWKTADERFFWNHYLTEDLRNFAhqdPRIDSFIQPVIYGYAKTVDAVLN-ATPIVLGLITRRSIFRAGTRYFRRGVDKDGNVGNFNETE
         .. .| .||||.||..|...| ..    .  .... |.|.|....    ..  . . | ||.|||. ||||||.|||.|.|||| ||.|||
eekeeeskslpllkevderFvWNrnllkplielk...ldlsrwllpliqGfveqrsievkskkkveltLIsRrsvkraGtRylrRGidddGnvANfvEtE

QILLAENpeSEKIHVFSFLQTRGSVPIYWAEINNLKYKPNLVLG---ENSLDATKKHFDQQKELYGDNYLVNLVNQKGHELPVKEGYESVVHAL-----N
||. ...  .|. .||||.|.|||||..| . .||..||. ..    |.| .|.||||..... ||. ..|||...||.| ...| ||. ...|     .
qivsekk..eeskrvfSfvqiRGSvPlfWeqasnlslkpkikitrsseasqkafkkHfkklikrYgkivvvnLlekkgrEkkLseayeelinklnkklke

DPKIHYVYFDFHHECRKMQWH
. |..|..||||.||......
kkklkyiefDfhkeckgkkfe
subfamily_FIG4_pd Subfamily FIG4 56-510 3.5e-74 241.2 In-house 71-546 (569) alignment 
Range on Protein: 56-510
Range on HMM: 71-546/569.0
ASLMGFIKLKLNRYAIIANTVEETGRFNGHVFYRVLQHSIVSTKFNSR---IDSEEAEYIKLLELHLKNSTFYFSYTYDLTNSLQRNEK----------V
  ..||...    | |.    .. .   ||. |.. . .... . .|      |.|| | ||..    ...|||||.||||..|| |            .
yGilGfvrflegyylilvtkrkkvaviGghaiykiedialikitedskksekssdearylklfkdvdltknfyfsysydltrtlqtnlllsdsnrekeka

GPA------ASWKTADERFFWNHYLTEDLRNFAHQdpriDSFIQPVIYGYAKTVDAVLNATPIVLGLITRRSIFRAGTRYFRRGVDKDGNVGNFNETEQI
 ..      |.  .|.|.| ||..| | |..  ..     .... .|.|. . ..  . . .| . ||.|||   ||.|...|||...|.| |  |||||
edrvditieakkldanekfvWnnflleplkdtvkt....fdWlleiihGfvsqskisvlgksiyvtliarrsskfaGarflkrGvnnkGdvaneveteqi

L-LAENPESEKIHVFSFLQTRGSVPIYWA-EINNLKYKPNLVLGE--NSLDATKKHFDQQKELYGDNYL-VNLVNQ---KGHELPVKEGYESVVHALND-
.  | . .... .. ||.|.|||||.||  ....|. ||.. . .    ..|.  |||.  . ||   . .||| .   . .|  ..| .|. .. ||. 
vheasegsldsdryssfvqlrGsvPlyWsqdasklvtkPpikidvvdPfasaaalhfddlfqryGspiiilnlvkkkekrkresilleefeaaieylnef

----PKIHYVYFDFHHECRKMQWHRVKLLiDHLEKLGLSNEDFFHKVIDSNGNTveivnEQHSVVRTNCMDCLDRTNVVQSVLAQWVLQKEFESADVVAT
     |..|. .|...  .. . . .. | ... .  . .. .|..  |..  .      |. .|||||.|||||||. | |...  |.  ..|  ... 
lPeekklkyiswdmaraskskeenvlevl.ekyaeksvkktGiflsapdlestk.....iqeGivrtnCvdcldrtnaaqfvigkvalgyqlkslGiide

gSTWEDNAPLLTSYQNLWADNADAVSVAYSGTGALKTDFTRTGKRTRLGAFNDFLNSASRYYQNNWTDGPRQDSYDLFLGGFRPHTA
 |. | .. . .  ..|. |  | ... |.|.   .|  | .  ..     .| |.. .||| | ..|  .||. .|||| ..|...
.sklefdsdvvrlleelyedlGdtlalqygGsqlvntiktyrkiaqwssksrdiletlkryysnsfvdadkqdainlflGvyspreg
subfamily_Synaptojanin_pd Subfamily Synaptojanin 58-505 2.2e-72 235.6 In-house 9-437 (754) alignment 
Range on Protein: 58-505
Range on HMM: 9-437/754.0
LMGFIKLKL----NRYAIIANTVEETGRFNGHVFYRVLQHSIVSTKFNSRIDseeaEYIKLLELHLKNSTFYFSYTYDLTNSLQRNEKVGPAASWKTADE
|.| ..|.      .. ..   ... |. ..   ... . ..|| . ... .    ..|  |.  |.  ||||| . | ...|. . .   . . .. |.
llGvlrlnagdetlsflvlvtgcksvGkisdaeifkitstelvslrseasde....driielkkllasgtfyfsssadsasrldlslsaqrrkqeesedn

RFFWNHYLTEDLRNFAHQdprIDSFIQPVIYGYAKTVDAVLNATPIVLGLITRRSIFRAGTRYFRRGVDKDGNVGNFNETEQILLAENpesekiHVFSFL
|||||. |   |..|. .    |... .|. |  .       |  .   ||.| |  |||||.  |||...||| || ||||..|...      .| ||.
rffWnrslhlhlqrfgvn...cddWllkvmcGsveirtvyagakqakaalisrlsceraGtrfnvrGvndeGnvanfveteqvilldd......kvtsfv

QTRGSVPIYWAE--INNLKYKPNLVLG-ENSLDATKKHFDQQKELYGDNYLVNLVNQKGHELPVKEGYESVV-HALNDPKIHYVYFDFHHECRKMQWHRV
|.|||||..|    ..  . | .|  | | |  | ..|..|.|| ||.  .|||. .|. |  ... ...   .   ......| ||.|....  . . .
qirGsvPlfWeqPGlqvGshkvklsrgfeasaaafdrhleqlkeryGevvivnllGskegeevlskafkkhlkasehakdvpfvkfdyhqkvkggkkekl

KLLIDHLEKLGLSNEDFFHKvidsNGNtvEIVNEQHSVVRTNCMDCLDRTNVVQSVLAQWVLQKEFESADvvaTGSTWEDNAPLLTSYQNLWADNADAVS
. |...  || |....||..    .|.  |...||. |.|.||.||||||| ||.||.. ||.| .|  .    .|  .    .  ....||  | | .|
ekllkkqlklflesasffls....kgk..evekeqtGvlrvnClDCldrtnavqtvlglevlekqlealk...lsskesvvsrfeevfkslWsknGdeis

VAYSGTGALKTDftrtgkrTRLGAFNDFLNSASRYYQNNWTDGPRQDSYDLFLGG--F
  | |||||...       .. . ..|   | .|  |||. |. .|.. ||.| |  .
kiyaGtgalegk.......akvsklkdgarsvartiqnnfldsskqeaidllllgnty