Gene MSG5 in Saccharomyces cerevisiae

Synonym: YNL053W, MSG5

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily MSG5
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP056_AA protein Get Run
ScerP056_AA_231-377 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_MSG5_pd Subfamily MSG5 211-377 2.4e-96 313.5 In-house 2-164 (165) alignment
Range on Protein: 211-377
Range on HMM: 2-164/165.0
EDSDLNIDMVHAEIYQ-RTVYLDGPLLVLPPNLYLYSEPKLEDILSFDLVINVAKEIPNLEFLIPPemahkIKYYHIEWTHTSKIVKDLSRLTRIIHTAH
| ....|..|||||.. |.|||||||||||..|||||||||...|||||||||||||..||.|.|.     .|||||||.|.|||||||||||||||.|.
espnedielvhaeildvrrvyldgpllvlpeklylysepklkellsfdlvinvakeindlellvpa.....vkyyhiewehdskivkdlsrltriihaat

SQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAKDISPNMGLIFQLMEWGTMLSKNS
|..||||||||||.||||||||||||.||.|||.|||.|||.||.||||..|||||||||...|||.|
skrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmewevalskks

DSPc Dual specificity phosphatase, catalytic domain 242-371 1.3e-39 130.1 Pfam-A 1-132 (133) alignment
Range on Protein: 242-371
Range on HMM: 1-132/133.0
LYLYSEPKLE----DILSFDLVINVAKEIPNLeFLIPPEMAHKIKYYhIEWTHTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRY
|||.|... .    ..|...|||||.||.||  ..| ..  .....  .| ....||.|.|......|..|...|||.|||||.|.||||.||.||.|..
lylgskstaslalleklgitlvinvtkevpnn.naikkseieylrip.vedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmkt

YGLSLNDAYNKLKGVAKDISPNMGLIFQLMEWGT
..||||.||. .|  .. ||||.|...||.|. .
knlslneAyefvkerrskispnagflrqLleyer

DSPc Dual specificity phosphatase, catalytic domain 242-371 1.3e-39 130.1 In-house 1-132 (133) alignment
Range on Protein: 242-371
Range on HMM: 1-132/133.0
LYLYSEPKLE----DILSFDLVINVAKEIPNLeFLIPPEMAHKIKYYhIEWTHTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRY
|||.|... .    ..|...|||||.||.||  ..| ..  .....  .| ....||.|.|......|..|...|||.|||||.|.||||.||.||.|..
lylgskstaslalleklgitlvinvtkevpnn.naikkseieylrip.vedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmkt

YGLSLNDAYNKLKGVAKDISPNMGLIFQLMEWGT
..||||.||. .|  .. ||||.|...||.|. .
knlslneAyefvkerrskispnagflrqLleyer

PTPc_motif_SM00404 240-371 2.7e-37 122.8 In-house 7-139 (140) alignment
Range on Protein: 240-371
Range on HMM: 7-139/140.0
PNLYLYSEPKLE-----DILSFDLVINVAKEIPNLeflippEMAHKIKYYHIE--WTHTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVA
|.|||.|..| .     . |....||||..|...       .   .... .|.   ....|..|.|......|..|...|.|.|||||.||||||.||.|
phlylgskskaqnpallkklgithvinvteevslt......kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliia

YIMRYYGLSLNDAYNKLKGVAKDISPNMGLIFQLMEWGT
|.|||..|||..||. .|  .. ||||.....||.|. .
YlmryrqlslaeayefvkerRpiispnlnfvrqLieyek

0044763 (Phosphotyrosine protein) phosphatases II 230-377 1.1e-29 98.8 In-house 18-174 (178) alignment
Range on Protein: 230-377
Range on HMM: 18-174/178.0
YLDGPLLVLPPNLYLYSEPKLEDIL-----SFDLVINVAKEIPNLEFLIPPEMAHK--IKYYHIEW--THTSKIVKDLSRLTRIIHTAH-SQGKKILVHC
.   ..    |.||| | |  .|.       .....|...|...  .  .|.   .  |.|.|| .   ..  . . . .....|..|. ..|...||||
sdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHC

QCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAKdISPNMGLIFQLMEWGTMLSKNS
..||.||..|..||.|...||||..|.. .. .   |.||.| . ||.|.  .| |.|
saGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllkes

subfamily_DSP10_pd Subfamily DSP10 252-376 1.1e-25 84.3 In-house 31-156 (159) alignment
Range on Protein: 252-376
Range on HMM: 31-156/159.0
D-----ILSFDLVINVAKEIPNLEflippEMaHKIKYYHIE--WTHTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLND
|      |. . |.||....||       |  ...|| .|.   |.. .. .        |. |...|...||||| |.||||....||.|.. .|||||
dldaldrlnitavlnvttsvPnef.....ee.ealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvviaYlmkhlnlslnd

AYNKLKGVAKDISPNMGLIFQLMEWGTMLSKN
||.  |     ||||.. . ||.|.   |.|.
aykfvkekrpiisPnLnfmGqLlefekelnks

0048179 (Phosphotyrosine protein) phosphatases II 239-372 3.6e-25 83.8 In-house 8-143 (144) alignment
Range on Protein: 239-372
Range on HMM: 8-143/144.0
PPNLYLYSEPKLEDILS-----FDLVINVAKEIPNLEFLIPpemahKIKYYHIEWT--HTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIV
 |.||| | | ..|.       ...|||.. | .. ..  .      |.|.|. |   ..  . ..| .. ..|..|...|...||||..||.|...|..
lpglylgslptaldlellkklgittvinlteeyepeflere.....giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlva

AYIMRYYGLSLNDAYNKLKGVAKDISPNMGLIFQLMEWGTM
||.|...||||..|.. ..     . ||.| . .|.|....
aylmkklglsleealalvrsrrpgavpnpgqlrfLleyekl

0048076 (Phosphotyrosine protein) phosphatases II 240-372 1.1e-24 82.1 In-house 9-141 (145) alignment
Range on Protein: 240-372
Range on HMM: 9-141/145.0
PNLYLYSEPKLEDILS-----FDLVINVAKEIPNLEflippemAHKIKYYHIEW--THTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVA
|.||| | |  .|.       . .|.|.. |...||       .. |.|... |   ..  . ..| .. ..|..|...|...||||. ||.|...|..|
pglylgslptaldlellkdlgittvlnltselelle.......rlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaa

YIMRYYGLSLNDAYNKLKGVAKDISPNMGLIFQLMEWGTM
|.|...|.|| .|.....     . ||.| . .|.|. ..
ylmlllgvsleealelvrsqrpgavpnpgqlrflyefele

subfamily_DSP12_pd Subfamily DSP12 274-375 3.5e-24 80.0 In-house 45-145 (155) alignment
Range on Protein: 274-375
Range on HMM: 45-145/155.0
PPEMAHkIKYYHIEWTHTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAKDISPNMGLIFQLMEWGTML
 .   .  |. .|  . .  |.. | . .. |. | ......||||| |||||.....||.|....|||..|....| . ..|.|| | . ||  .  | 
kkgkvs.tkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkpeiepNegFleQLklfekmg

SK
 |
ck

0049772 (Phosphotyrosine protein) phosphatases II 274-373 5.2e-24 80.9 In-house 173-273 (314) alignment
Range on Protein: 274-373
Range on HMM: 173-273/314.0
PPEMAHK-IKYYHIEWTH-TSKIVKDLSRLTRIIHTAhSQGKKILVHCQCGVSRSAS-LIVAYIMRYYGLSLNDAYNKLKGVAKdISPNMGLIFQLMEWG
|.   .  |||..| ..  .  . .|. .. ..|..| ..|...||||. |..|... ...||.|...|.||..|.. ..     |.||.|.| ||... 
pelferlgikylripvpDgsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqye

TML
 .|
fil

0041856 (Phosphotyrosine protein) phosphatases II 234-376 1.7e-23 78.6 In-house 18-175 (182) alignment
Range on Protein: 234-376
Range on HMM: 18-175/182.0
PLLVLPPNLYLYSEPKLEDIL-------------------SFDLVINVAkeipnlEFLIPPE--MAHKIKYYHIEWTHTSKIVkdLSRLTRIIHTAHSQG
.|    .|||| | |  . |.                    . ...|..      |.| .||  . . |.|... |   .     |. | ..|......|
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt......eelywpellerlgiqylylpwpDhgvpd..ldelldfieevleeg

KKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAK--DISPNMGLIFQLMEWGTMLSKN
...|||| .||.|...|..||.|...|.|| .|.. ..       |.||.. . ||...  .| |.
gpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkk

subfamily_DSP14_pd Subfamily DSP14 258-377 1.8e-23 77.2 In-house 34-148 (157) alignment
Range on Protein: 258-377
Range on HMM: 34-148/157.0
LVINVAKEIPNLEFlippEMAHKIKYyHIEWTHTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAKDIS
|.|||. |.|| ..    .  ...|   .| ....|..| . . .  |.... .| |.||||  |||||||| .||.|.|  |||..||. .| .   |.
liinvtvelpntkl....kdiervkv.pveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylmkyeklsLreayklvksaRpiir

PNMGLIFQLMEWGTMLSKNS
||.|   ||... . | ..|
PNvGFwkqlidyEkklkgks

subfamily_DSP6_pd Subfamily DSP6 254-375 2.3e-23 76.4 In-house 38-156 (158) alignment
Range on Protein: 254-375
Range on HMM: 38-156/158.0
LSFDLVINVAKEIPNLeFlippEMAHKIKYYHIEW--THTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKG
|.   |.||....||  |    | ....||..|     .. .. | .    . |  |.|. .|.||||  |.|||  ...||.|... |||||||. .| 
lkikyvlnvtsnlpnk.f....eesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtlaylmkklalslndaydlvkk

VAKDISPNMGLIFQLMEWGTMLSK
   .||||. .. ||...  .|. 
rksnisPnfnfmgqlldferslrl

subfamily_DSP1_pd Subfamily DSP1 234-374 3.4e-22 73.3 In-house 17-157 (163) alignment
Range on Protein: 234-374
Range on HMM: 17-157/163.0
PLLVLPPNLYLYSEPKLED--I---LSFDLVINVAKEIPNLeFliPPemAHKIKYYHIEWTHTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSAS
|   . . ||| || .  .  |   |    ..||.||..|  |  .    .. |  ..| ...  | . ...    |....... |.|.||| |.|||..
PvekildfLylGsetvasnleiLkslgitailnvskeldnv.f..ed..lfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsst

LIVAYIMRYYGLSLNDAYNKLKGVAKDISPNMGLIFQLMEWGTMLS
|..||.|.   .||..|..  | . . ||||.| . ||... . | 
lclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkll

subfamily_Slingshot_pd Subfamily Slingshot 257-374 2.1e-21 70.1 In-house 46-158 (169) alignment
Range on Protein: 257-374
Range on HMM: 46-158/169.0
DLVINVAKEIPNleFlippeMAHKIKYYHIEW--THTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAK
. ..||.||| |  |      ..|..|..|    .......|   .  . |..|...| |.||||. ||||||| ..|| |. |||||..|.. .|   .
eyilnvtkeidn..f.....fpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviayamkeyglsleealeyvkerrs

DISPNMGLIFQLMEWGTMLS
 | || |.. || |.  .|.
vikPnkgflkqleeyeGile

0046846 (Phosphotyrosine protein) phosphatases II 228-374 5.9e-21 70.5 In-house 5-173 (176) alignment
Range on Protein: 228-374
Range on HMM: 5-173/176.0
TVYLDGPLLVLPPNLYLYSEP---------KLEDIL------SFDLVINVAKEIP----NLEFLIPPEMAHKIKYYHIEWT--HTSKIvKDLSRLTRIIH
  .||..|  ...||.| | |          |.| |       ...|.|. .|.     ..  . | .....|.|.|. |   ..  . ..| .| ..|.
llgldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefir

TAHSQGKKILVHCQCGVSRSASLIVAYIMRY-YGLSLNDAYNKLKGVAK-DISPNMGLIFQLMEWGTMLS
.| ..|...||||. |..|.. |..||.... .|||...|. ... .    . .... . .|.|.  .| 
ealkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefellll

subfamily_DSP19_pd Subfamily DSP19 259-371 6.8e-21 69.2 In-house 41-148 (152) alignment
Range on Protein: 259-371
Range on HMM: 41-148/152.0
VINVAKEIPNLeFlippemAHKI--KYYHIEWTHTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAKDI
..||| ..||. |      ....  .  .|  .   .... |.. .  |. |.|.   .||||. |||||||...||.|.   |||..|..... . . |
ilnvatgvpnv.f......pkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylmkkeelsleealelvrearpci

SPNMGLIFQLMEWGT
.|| | | || |. .
kPneGFikqLkeyea

subfamily_DSP8_pd Subfamily DSP8 255-375 1.6e-20 67.3 In-house 40-156 (159) alignment
Range on Protein: 255-375
Range on HMM: 40-156/159.0
SFDLVINVAKEIPNLEFLIPPEmAHKIkyyHIEWTHTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAK
  . |.|. .. |.||.|   .  ...    .. ... |..  . . .  |  |.|. ...|||.  | ||||....||||..  .||..||. .|   .
gisyvlnasnscpkleelkesk.flrv...PvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaiayimktlemsldeayrfvkekrp

DISPNMGLIFQLMEWGTMLSK
 ||||.  . ||.|.   | .
tispnlnflgqLleyekelkl

0045098 (Phosphotyrosine protein) phosphatases II 253-370 4.2e-20 67.7 In-house 128-268 (278) alignment
Range on Protein: 253-370
Range on HMM: 128-268/278.0
ILSFDLVINVAKEIPNLEFLIPPEMAHKIKYYHI-EW----THTSKIVKDLSRLTRIIHTAHS--------------QGKKILVHCQCGVSRSASLIVAY
.  .| .. .  .. || .  .  . ......|.  |    .... |.| . .|.. |. |..              .|...||||. ||.|.. |..||
eevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaay

IMRYY---GLSLNDAYNKLKGVAKD-ISPNMGLIFQLMEWG
.|...   |..| .|...|.      . .|.. . .|.|. 
lmlelleggvdlleavkelrsqRpglavqnleqyrflyefl

subfamily_STYXL1_pd Subfamily STYXL1 234-375 6.4e-19 61.7 In-house 11-155 (157) alignment
Range on Protein: 234-375
Range on HMM: 11-155/157.0
PLLVLPPNLYLYS-----EPKLEDILSFDLVINVAKEIPNLEFLIpPEmAHKIKYYHIEWTHTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSAS
|  ||| .|||       .|...  |    ..||...  .|   . .. . |.   ..| .  ..... |... . |.. . .|. .||  . |.||||.
PvevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagv.ad.vakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaa

LIVAYIMRYYGLSLNDAYNKLKGVAKDISPNMGLIFQLMEWGTMLSK
.|.||.| .. ..|..||..||   ... || ... || ||  .|..
viiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekqllg

0043147 (Phosphotyrosine protein) phosphatases II 257-373 1.2e-18 62.9 In-house 46-160 (172) alignment
Range on Protein: 257-373
Range on HMM: 46-160/172.0
DLVINVAKEipnlEFLIPPEMAHKIKYYHIEWT-HTSKIVKDLSRLTRIIHT--AHSQGKKILVHCQCGVSRSASLIVAYIMRyYGLSLNDAYNKLKGVA
....|. ..    . . .... . |.|... |  |.  . . | .. ..|..  | |.|...||||  ||.|.. |..||.|. .|||| .|.. ..   
thivnltel....lydpellerlgiqylylpwpDhgvpllellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.lglsleeavalvrekR

KDISPNMGLIFQLMEWGTML
  ...| . . .|...  .|
pgavqnpsqyrflyyfekll

subfamily_DSP15_pd Subfamily DSP15 280-375 5e-18 59.6 In-house 46-141 (151) alignment
Range on Protein: 280-375
Range on HMM: 46-141/151.0
KIKYYHIEWTHTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAKDISPNMGLIFQLMEWGTMLSK
. |..... |   |. | ..   ..||.. ......||||  |||||. |.|||.|    |. .|| . .|       ||.|   ||.|. .. .|
eYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyektklk

0037934 (Phosphotyrosine protein) phosphatases II 226-369 8.6e-18 60.2 In-house 30-237 (243) alignment
Range on Protein: 226-369
Range on HMM: 30-237/243.0
QRTVYLDGPLLVLPPNLYLYSEPKLEDILS-------------FDLVINVAKEI----PN-------------------------------LEFL---IP
. . |... |   .|.|.. . |  | . .             .. .... ...     .                               |.     ..
egsdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldld

PEMAHKIKYYHIEWTH------TSKIVKDLSRLTRIIHT-----AHSQGKKILVHCQCGVSRSASLIVAYIMRYY-GLSLNDAYNKLKGVAKD-ISPNMG
..  . |.|... | .      .. ... |. .. .|.      | ..|...||||  ||.|.. ||.||.| .. |..| .|...|.      . .. .
dltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtps

LIFQLMEW
 . .|.|.
qyrflyea

subfamily_STYX_pd Subfamily STYX 272-372 6.3e-17 55.2 In-house 54-156 (166) alignment
Range on Protein: 272-372
Range on HMM: 54-156/166.0
LIPPEMAHKIKYYHIE--WTHTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAKDISPNMGLIFQLMEW
|| |.. ....|  ..   . . .|.. | .   .| .. ..| |.||| ..|.||||.|..||||  |||   .|.  ..     |.|| |.. ||.|.
likpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkey

GTM
 ..
eai

0049260 (Phosphotyrosine protein) phosphatases II 258-373 8.6e-17 56.7 In-house 36-149 (152) alignment
Range on Protein: 258-373
Range on HMM: 36-149/152.0
LVINVAKEIPNLEFLIPPEMahkiKYYHIEW--THTSKIVKDLSRLTRIIHT-AHSQGKKILVHCQCGVSRSASLIVAYIMRyYGLSLNDAYNKLKGVAK
 .... .. .. ..  .  .    .|.|. |   .. ..   |  | ..|.  |...|...||||  ||.|.. |..||.|. .|.|| .|.. ..   .
tivmltellelgklkceqyi....qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.lgvsleeavalvrekRp

DISPNMGLIFQLMEWGTML
 . || | ...|.|. ..|
gavpnpgqlrflyefekll

subfamily_DSP3_pd Subfamily DSP3 280-375 1.1e-16 54.9 In-house 62-159 (162) alignment
Range on Protein: 280-375
Range on HMM: 62-159/162.0
KIKYYHIEWT--HTSKIVKDLSRLTRIIHTAHSQ-GKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGvAKDISPNMGLIFQLMEWGTMLSK
.|||. .| .   .... |  .. .. |..| ||   |.||||. |||||| |..||.| .  ..|..| .. .   ..| ||.| . ||.|  . |..
eikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrk.kReilPneGFlkqLaeldeelkr

0045450 (Phosphotyrosine protein) phosphatases II 277-369 2.4e-16 55.8 In-house 174-299 (307) alignment
Range on Protein: 277-369
Range on HMM: 174-299/307.0
MAHKIKYYHIEWT-------------------HTSKIVKDLSRLTRIIHTAHS------QGKKILVHCQCGVSRSASLIVAYIMRYYG--------LSLN
  ........| |                      .. .... | ..|. ...      .|...||||  ||.|....|.||.| ...        ..| 
hldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdll

DAYNKLKGVAKDISPNMGLIFQLMEW
.|...|.     . .| . . .|.|.
eavkllreqRpgavqnpeqyrflyea

0039614 (Phosphotyrosine protein) phosphatases II 277-369 3.4e-16 55.0 In-house 184-284 (297) alignment
Range on Protein: 277-369
Range on HMM: 184-284/297.0
MAHKIKYYHIEWTHTSKIVKDLSRLTRIIHTAHS---QGKKILVHCQCGVSRSASLIVAYIM-----RYYGLSLNDAYNKLKGVAKDISPNMGLIFQLME
. . . |... . ..  ....| .. .....|..   .|...||||  ||.|....|.||.|     ...|... .|...|.     . .... . .|..
tvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflyd

W
.
a

subfamily_MKPLT_pd Subfamily MKPLT 285-372 3.8e-16 53.1 In-house 72-159 (164) alignment
Range on Protein: 285-372
Range on HMM: 72-159/164.0
HIEWTHTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAKDISPNMGLIFQLMEWGTM
..| . .... . | |..  .  |   | ..||||. |.|||.|  ||..... |  |..||. ||     ..|| |.. || ..  .
kvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfeel

subfamily_MKPLV_pd Subfamily MKPLV 285-372 3.8e-16 53.1 In-house 72-159 (164) alignment
Range on Protein: 285-372
Range on HMM: 72-159/164.0
HIEWTHTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAKDISPNMGLIFQLMEWGTM
..| . .... . | |..  .  |   | ..||||. |.|||.|  ||..... |  |..||. ||     ..|| |.. || ..  .
kvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfeel

0040439 (Phosphotyrosine protein) phosphatases II 273-369 6.4e-16 54.2 In-house 135-241 (249) alignment
Range on Protein: 273-369
Range on HMM: 135-241/249.0
IPPEMAHKIKYYHIEWThTSKIVKDLSRLTRIIHTAHS------QGKKILVHCQCGVSRSASLIVAYIM-----RYYGLSLNDAYNKLKGVAKDISPNMG
  .|  .   .... |    .. .... | ..|. ...      .|...||||  ||.|.. .|.||.|     ...|..| .|...|.     . .| .
ydgesrtvlhiqytdwp.dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpe

LIFQLMEW
 . .|.|.
qyrflyea

0042113 (Phosphotyrosine protein) phosphatases II 238-369 1.2e-15 53.1 In-house 50-238 (245) alignment
Range on Protein: 238-369
Range on HMM: 50-238/245.0
LPPNLYLYSEPKLEDIL---------SFDLVINVAKEIPN---------------------------------------LEFLIPPEMAHKIKYYHIEWT
 .|.... . |  |..              .... .| ..                                       .. |  .|  . | |... | 
itpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwp

HTSKI--VKDLSRLTRIIHTAHS--QGKKILVHCQCGVSRSASLIVAYIM-----RYYGLSLNDAYNKLKGVAKDISPNMGLIFQLMEW
. .    ...| .. .....| .  .....||||  ||.|.. .|.||.|     ...|.|| .|. .|.     . .. . . .|.|.
dhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyea

subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 280-369 1.4e-15 51.1 In-house 52-143 (148) alignment
Range on Protein: 280-369
Range on HMM: 52-143/148.0
KIKYYHIEWTH--TSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAKDISPNMGLIFQLMEW
 |.|.|..        . .    ..  .. |...|...|||.| |||||. | .......   ||..|..  |   . . ||.| . || |.
gieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfkrvslkealalvkskrryvdpnlgfLkqLael

0036282 (Phosphotyrosine protein) phosphatases II 257-374 2e-15 52.4 In-house 38-170 (174) alignment
Range on Protein: 257-374
Range on HMM: 38-170/174.0
DLVINVAKEIPNLEFLI--------PPEMAHKIKYYHIEWT--HTSKIVKdLSRLTRIIHTAHSQ--GKKILVHCQCGVSRSASLIVAYIMRYYGL-SLN
  |... .|...  ...          .  . |.|... |   ..  . . | .. .....|.|.  |...||||  ||.|.. |..||.| ...| || 
ttvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrglleslv

DAYNKLKGVA---KDISPNMGLIFQLMEWGTMLS
||.. .. .      . .... . .| ... .||
daldlvrelRlqrpgmvqtpsQyrflyyfeklls

subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 278-371 4.8e-15 49.2 In-house 53-150 (154) alignment
Range on Protein: 278-371
Range on HMM: 53-150/154.0
AHKIKYYHIEWTH--TSKIVKDLSRLTRIIHTAH--SQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAKDISPNMGLIFQLMEWGT
.  |.| ..|       .|.. |..    |. |    .  |.|||.. ||||||.|...|.|    .||  |.  ||     |.|| |.. ||  .. 
gfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaallisylmdklkislslalellkdsryiikPnqGflkqleifek

PTEN_1 215-361 1.5e-14 49.2 In-house 20-179 (196) alignment
Range on Protein: 215-361
Range on HMM: 20-179/196.0
LNIDMVHAEIYQRTVYLDGPLLV-LPPNLYLYSEPKLEDIL------SFDLVINVAKEIPNLEFLIPPE--MAHKIKYYHIEWT--HTSKIVKDLSRLTR
|.. ... .|   ..  . |||  ....||. |.. ... |      .. ||.|.. | .. ..  ..|  ......|.|....  ... . . .  . .
ldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicks

IIHTAH--SQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAKDISPNMG
.|. .   ..|...||||. |..||. .. || |....|. ..|   ..     ..||..
fiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnsp

subfamily_LRR-DSP_pd Subfamily LRR-DSP 279-375 3e-14 46.8 In-house 162-260 (263) alignment
Range on Protein: 279-375
Range on HMM: 162-260/263.0
HKIKYYHI---EWTHTSKIVKDLSRLTRIIHTAHSQGKkILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAKDISPNMGLIFQLMEWGTMLSK
.  ||. |   | .   .| . . ..   |.    .|  .||||. |||||..|...|.|..  | ...|..  .     | ||.|.. ||. .   |..
klfkylsiddiedvdeadisqhfeetnafieeGrkkGG.vlvhcraGvsrsstlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklfc





0038934 (Phosphotyrosine protein) phosphatases II 275-369 3.4e-14 48.4 In-house 72-172 (194) alignment
Range on Protein: 275-369
Range on HMM: 72-172/194.0
PEMAHK--IKYYHIEWTH--TSKIVKDLSRLTRIIHT--AHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAKDISPNMGLIFQLME
||  .|  |.|... .    |.   . | |  .....  . ..|....|||  |..|.. |..||.. ..|.|...|.. .. . ... || . . .|..
peefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallk

W
.
r

0040438 (Phosphotyrosine protein) phosphatases II 277-369 1.8e-13 45.9 In-house 152-271 (317) alignment
Range on Protein: 277-369
Range on HMM: 152-271/317.0
MAHKIKYYHIEWTHT------------------SKIVKDLSRLTRIIHTAHSQ----GKKILVHCQCGVSRSASLIVAYIM-----RYYGLSLNDAYNKL
  . |.....| ...                   .. .... | .... ....    |...||||  ||.|....|.||.|     ...|... .|...|
elagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkel

KGVAKDISPNMGLIFQLMEW
.     . .. . . .|...
reqRpgavqtpeqyrflyda

0051082 (Phosphotyrosine protein) phosphatases II 255-368 2.4e-13 45.5 In-house 33-148 (151) alignment
Range on Protein: 255-368
Range on HMM: 33-148/151.0
SFDLVINVAKEIPNLeFLIP--PEMAHKIKYYHIEWTHTSKIVKDLSRLTRIIHTAHSQ-GKKILVHCQCGVSRSASLIVAYIMRyYGLSLNDAYNKLKG
 .. ..|. .| ..  ..    ||. .......|. ... ..   .  . .... . .. ....||||  |..|.. |...|.|  .|.||..|.. .. 
giktivnlrseeerg.ycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylml.lgvsleealeeyrl

VAK-DISPNMGLIFQLME
     . ||.. .|||..
krpgvvqpnqqflfqlfa

0043336 (Phosphotyrosine protein) phosphatases II 273-366 1.9e-12 42.7 In-house 168-269 (278) alignment
Range on Protein: 273-366
Range on HMM: 168-269/278.0
IPPEMAHKIKYYHIEWTHTSKIVkDLSRLTRIIHTAHS----QGKKILVHCQCGVSRSASLIVAYIM-----RYYGLSLNDAYNKLKGVAKDISPNMGLI
  .|  .   |... | . .    .|| | ........    .....||||  ||.|.. .|..|..     ...|..| .|...|.     . ..   .
gdgesrtvthyhylgwpdhgvpe.slsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqy

FQL
 .|
rfl

0036941 (Phosphotyrosine protein) phosphatases II 279-366 5.1e-12 41.2 In-house 168-269 (297) alignment
Range on Protein: 279-366
Range on HMM: 168-269/297.0
HKIKYYHIEWTHTSKIVKDLSRLTRIIHTAHS------QGKKILVHCQCGVSRSASLIVAYIM--------RYYGLSLNDAYNKLKGVAKDISPNMGLIF
......|.      ..  . . | ..|. ...      .|...||||  ||.||...|.|..|        ...|... .|..||.     . .. .   
rtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyr

QL
.|
fl

0051429 (Phosphotyrosine protein) phosphatases II 277-369 3.1e-11 39.0 In-house 67-220 (272) alignment
Range on Protein: 277-369
Range on HMM: 67-220/272.0
MaHKIKYYHIEWTHTSKIVK----------------------------------------------------DLsrLTRIIHTAHSqGKKILVHCQCGVS
  . |.|.|. .  .|                                                        .   | ....  .. |...||||  |..
w.pgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.ggpvlvHCsaGkd

RSASLIVAYIMRyYGLS--------------LNDAYNKLKGVAKDISPNMGLIFQLMEW
|.. .......  .|.|              | .|...|. .   . .. . . .|.|.
RTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyea

subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 298-369 3.4e-11 36.4 In-house 66-137 (145) alignment
Range on Protein: 298-369
Range on HMM: 66-137/145.0
LSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAKDISPNMGLIFQLMEW
.  .| .|   . .|  ..|||  ||||| .. ||..|.| ...| .|  ...       ||. .. .|.. 
fdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkycnmtlseaarqvrsnrllaypnvtflknllnl

subfamily_PTPMT1_pd Subfamily PTPMT1 292-356 5.3e-11 37.2 In-house 87-151 (171) alignment
Range on Protein: 292-356
Range on HMM: 87-151/171.0
SKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAKDI
.  ...|..  ..|.  .|.||.. |||. | .|||.|. .|.|  . ||...| . ||   | |
apdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkii

0047943 (Phosphotyrosine protein) phosphatases II 283-350 2.2e-10 36.0 In-house 173-248 (273) alignment
Range on Protein: 283-350
Range on HMM: 173-248/273.0
YYHIEWTHTSKIVKDLSRLTRIIHTAHS---QGKKILVHCQCGVSRSASLIVAYIM-----RYYGLSLNDAYNKLK
|...   ..   ...| .. .....|..   ......|||  ||.|....|.....     ...|... .|...|.
ytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllr

0048567 (Phosphotyrosine protein) phosphatases II 277-355 3.8e-10 34.3 In-house 26-120 (157) alignment
Range on Protein: 277-355
Range on HMM: 26-120/157.0
MAHKIKYYHIEW--THTSKIVK----DLS-------RLTRIIHTAHSQGKKILVHCQCGV---SRSASLIVAYIMRYYGLSLNDAYNKLKGVAKD
  .. .|..|.    . . . .    .|.       .| ....    .||.| |||  |    .|.| || .|.. ..|.. ..|.. |. |  .
slynalyFsiddglvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpg

0046845 (Phosphotyrosine protein) phosphatases II 279-349 1.4e-09 33.2 In-house 165-249 (284) alignment
Range on Protein: 279-349
Range on HMM: 165-249/284.0
HKIKYYHI-EWTHT-----SKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYY--------GLSLNDAYNKL
......|. .| .      .... .. || | .......|..|.|||  ||.|.. .|..... ..        |... .|...|
rtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrl

0050432 (Phosphotyrosine protein) phosphatases II 283-349 3e-09 32.1 In-house 201-274 (308) alignment
Range on Protein: 283-349
Range on HMM: 201-274/308.0
YYHI-EWThTSKI---VKDLSRLTRIIHTAHsQGKKILVHCQCGVSRSASLIVAYIM-----RYYGLSLNDAYNKL
 .|   |    ..   ...| .. ..... . .|..|.|||  ||.|.. .|.....     . .|... .|..||
hfhytnWp.dhgvPpspeilldflelvrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkkl

0051299 (Phosphotyrosine protein) phosphatases II 279-349 3.8e-09 31.9 In-house 182-261 (288) alignment
Range on Protein: 279-349
Range on HMM: 182-261/288.0
HKIKYYHIEWTHTSKIVKDLSRLTRIIHTAHSQ----GKKILVHCQCGVSRSASLIVAYIM-----RYYGLSLNDAYNKL
.... .|        .  ... | .... ....    |. ..|||  ||.|.. .|.....     . .|... .|...|
rtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrl

subfamily_Dicty-DSP-Subfam1_pd Subfamily Dicty-DSP-Subfam1 287-347 6e-08 25.5 In-house 42-101 (128) alignment
Range on Protein: 287-347
Range on HMM: 42-101/128.0
EWTHtSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYN
.|..  |. . .     |. . .     . |||.||. |.  .. .|.|.| | .|..| .
dwsa.dklpyrirdyrnillserelplvlyvhcecgcdrtgevlasyvmkykgydlkkale

subfamily_Dicty-DSP19-1_pd Subfamily Dicty-DSP19-1 287-347 6e-08 25.5 In-house 41-100 (128) alignment
Range on Protein: 287-347
Range on HMM: 41-100/128.0
EWTHtSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYN
.|..  |. . .     |. . .     . |||.||. |.  .. .|.|.| | .|..| .
dwsa.dklpyrirdyrnillserelplvlyvhcecgcdrtgevlasyvmkykgydlkkale

PTPc_DSPc_SM00012 282-335 8.5e-08 27.7 In-house 4-62 (105) alignment
Range on Protein: 282-335
Range on HMM: 4-62/105.0
KYYHIEWTHTsKI---VKDLSRLTRIIHTAHSQ---GKKILVHCQCGVSRSASLIVAYIM
.|.. .|... ..   .... .| | ... ...   .| ..|||. ||.|.. .....|.
hyhytgwpdh.gvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldil

subfamily_CDC14_pd Subfamily CDC14 289-345 3e-07 24.6 In-house 246-296 (328) alignment
Range on Protein: 289-345
Range on HMM: 246-296/328.0
THTSKIVKdlsRLTRIIHTAhsqGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDA
| ...|||   ....|. .|     .| |||. |. |  .|| .|.|. |... ..|
tPsdaivk...kfleiaeka...eGaiavhCkaGLGrtGtLiacylmkhyrftaaea

DSPc_SM00195 276-335 2.1e-06 22.7 In-house 155-218 (263) alignment
Range on Protein: 276-335
Range on HMM: 155-218/263.0
EMAHKIKYYHIEWTHTSKIVKDLSRLTRIIHTAHSQGK----KILVHCQCGVSRSASLIVAYIM
| ..|.. |...    ... .. . ........... .     |.|||. ||.|....... |.
eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidii

PTPc_SM00194 276-335 2.1e-06 22.7 In-house 155-218 (263) alignment
Range on Protein: 276-335
Range on HMM: 155-218/263.0
EMAHKIKYYHIEWTHTSKIVKDLSRLTRIIHTAHSQGK----KILVHCQCGVSRSASLIVAYIM
| ..|.. |...    ... .. . ........... .     |.|||. ||.|....... |.
eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidii

subfamily_PTPDC1_pd Subfamily PTPDC1 277-347 2.2e-06 22.2 In-house 79-149 (182) alignment
Range on Protein: 277-347
Range on HMM: 79-149/182.0
MAHKIKYYHIEWT-HTSKIVKDLSRLTRIIHTAHSQGkKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYN
|...| .| . |. . .. .. .  . .... | ..| |. |||  |  |   || .|..    |. ..| .
meqgiyvynfgwkDygvasleriLdivkvvafalqeg.kvavhChaGlGrtGvliacylvyakrltaekaik

subfamily_Laforin_pd Subfamily Laforin 291-344 3.9e-06 19.8 In-house 89-142 (183) alignment
Range on Protein: 291-344
Range on HMM: 89-142/183.0
TSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLND
|   |. | .   ..|.   .|... |||..|| ||..... ...   | ||. 
tesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslak

Y_phosphatase Protein-tyrosine phosphatase 282-335 5.2e-06 21.4 Pfam-A 137-193 (235) alignment
Range on Protein: 282-335
Range on HMM: 137-193/235.0
KYYHIEWThTSKIVKDLSRLTRIIHTAHSQG----KKILVHCQCGVSRSASLIVAYIM
 . . .|.  ... .. . |...|.  ...     ....|||  ||.|....... |.
qlhytnWp.dhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldil

Y_phosphatase Protein-tyrosine phosphatase 282-335 5.2e-06 21.4 In-house 137-193 (235) alignment
Range on Protein: 282-335
Range on HMM: 137-193/235.0
KYYHIEWThTSKIVKDLSRLTRIIHTAHSQG----KKILVHCQCGVSRSASLIVAYIM
 . . .|.  ... .. . |...|.  ...     ....|||  ||.|....... |.
qlhytnWp.dhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldil