Gene OCA2 in Saccharomyces cerevisiae

Synonym: YNL056W, OCA2

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family OCA
Subfamily OCA
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP057_AA protein Get Run
ScerP057_AA_2-161 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Y_phosphatase2 Tyrosine phosphatase family 3-163 2e-63 205.1 Pfam-A 1-159 (165) alignment 
Range on Protein: 3-163
Range on HMM: 1-159/165.0
YIPPLNFSPVVStdvSLYRSGYPMPLNYSFIKHqLHLKTIIYIGDKDRPLEEYQsFLESEKIKYYHIFMDSSRD---EGIQERMNQVLHLVLDVRNYPIL
..||||||.|.|   .||||.||.. |.||.|. |.|||||.. ..... .|.| |||.||||.|||...|...   | ........|.|.|...|||.|
lvpplnFsaves...elyrssyprasnfsflks.LkLktiislspeeesqdelq.fleeekiklyhiaiesnkeelveiksdllkkalklllnkenypvl

VHSNKGKHRVGVVVGIIRkLLQGWSTAGICQEYGLFSGGMKDGVDLEFITMFETNLKIPRNV-IP
.|...||||.|.|.|..|  ||.||.| |..|| .||| .|. || |||..|...|......  .
lhckrGkhrtglvigclR.klqkWslasilnEyrrFsgskkrivdeefienfdselevekknkkl
subfamily_OCA_pd Subfamily OCA 3-152 1.3e-30 96.7 In-house 144-282 (282) alignment 
Range on Protein: 3-152
Range on HMM: 144-282/282.0
YIPPLNFSPVVSTDV-----SLYRSGYPMPLNYSFIKHQLHLKTIIYIGDKDRPLEEYQSFLESEKIKYYHIFMdssrdegiqermnQVLHLVLDVRNYP
 .||.||| | ....     .|.|...|...|..|. ..|.|||........ . |....||.|..||.... .             .||. .||..||.
lvpprnfslveeykdkpvisgllrlllpeeenlpfLidrlglktaliLdaeeveretiadflasseiklvslrn.............evlkdlldndnya

ILVHSnkgKHRVGVVVGIIRKlLQGWSTAGICQEYGLFSGGMKDGV-DLEFITMFE
....    ... ..|....|| .. .... |..|| .|.. ... . . ..|..|.
velsc...qaktdtvlkvLrk.dkkygstsiyleyigFtledqeslksillielfd
0051082 (Phosphotyrosine protein) phosphatases II 4-150 2e-27 91.1 In-house 3-146 (151) alignment 
Range on Protein: 4-150
Range on HMM: 3-146/151.0
IPPLNFSPVVSTdvsLYRSGYPMPLNYSFIkHQLHLKTIIYIGDKDRPLeEYQSFLESEKIKYYHIFMDSSRDEGI---QERMNQVLHLVLDVRNYPILV
 ...||| | .    |||||.|.. .. .. ..|..|||... ... .   . ..|... |...|| ...  | |.   .. ....|.|.|| .|.|.||
sdyinfsyvtgg...lyrsggpladflell.kelgiktivnlrseeerg.ycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlv

HSNKGKHRVGVVVGIIRKLlQGWSTAGICQEYGLFSGGMKDGVDLEFITM
| . ||.| |..|.....| .|.| . . .|| |. .|.    .  .. .
HCsaGkgRTGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfql
0051429 (Phosphotyrosine protein) phosphatases II 19-143 1e-17 60.1 In-house 24-197 (272) alignment 
Range on Protein: 19-143
Range on HMM: 24-197/272.0
LYRSGYP---MPLNYSFIkHQLHLKTIIYIGDKDR----PLEEYQsflesEKIKYYHIFMDSSRDEGIQ-------------------------------
|||||.|    . .. .. ..|..|||. . . .     . . |      . |.|.|. . .. .. |                                
lyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdryw.....pgirylhlpilddsaptilygalrvtllseellldyilrellltlllsag

--------------------ERMNQVLHLVLDvrNYPILVHSNKGKHRVGVVVGIIRKLlQGWSTAGICQEYGLFSGGMKDGV
                    | . ..|.|.||  ..|.||| . ||.| |.|| ... | .|.|   |...| |.. .. . |
earevmhlhytdwpdhgvpqeallellellld..ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeav
0048076 (Phosphotyrosine protein) phosphatases II 18-139 1.3e-14 49.6 In-house 10-125 (145) alignment 
Range on Protein: 18-139
Range on HMM: 10-125/145.0
SLYRSGYPMPLNYSFIKHqLHLKTIIYIgdkdrplEEYQSFLESEKIKYYHIFMDSSRDEGIQERMNQVLHLVLDV--RNYPILVHSNKGKHRVGVVVGI
.||....|..|.. ..|. |...|.. .         ....|| . |.|... ..      . | . ..|... ..  ...|.||| . |..| |..|..
glylgslptaldlellkd.lgittvlnl.......tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaa

IRKLLQGWSTAGICQEYGLFSGGM
   ||.|.|   . ...     |.
ylmlllgvsleealelvrsqrpga
0048179 (Phosphotyrosine protein) phosphatases II 18-139 1.7e-14 49.3 In-house 10-127 (144) alignment 
Range on Protein: 18-139
Range on HMM: 10-127/144.0
SLYRSGYPMPLNYSFIKHqLHLKTIIYIGDKdrpleEYQSFLESEKIKYYHIFMDSSRDEGIQERMNQVLHLVLDV--RNYPILVHSNKGKHRVGVVVGI
.||....|..|.. ..|. |...|.| . ..      .. ||| | |.|.|. ..      . | ....|... ..  ...|.||| . |..| |..| .
glylgslptaldlellkk.lgittvinltee.....yepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaa

IRKLLQGWSTAGICQEYGLFSGGM
 . ...|.|   . ...     |.
ylmkklglsleealalvrsrrpga
0044763 (Phosphotyrosine protein) phosphatases II 3-161 2.1e-14 49.0 In-house 17-176 (178) alignment 
Range on Protein: 3-161
Range on HMM: 17-176/178.0
YIPPLNFSPVVSTdvsLYRSGYPMPLNYSFIkHQLHLKTIIYIGDKDRP--LEEYQSFLESEKIKYYHIFMDSSRDEGIQERMNQVLHLVL---DVRNYP
.....|.| ..     ||....|.. .. .. ..|....|. . . ...  |.... ..|.. |.|.|| .. . .  . | . ......    | .. |
rsdyinaseilpg...lylgslppaddlell.kelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggp

ILVHSNKGKHRVGVVVGIIRKLLQGWSTAGICQEYGLFSGGMKDGVDLEFITMFETNLKIPRNV
.||| . |..| |..| .   . .|.|   . ...     ..    .|... .||  |.  ...
vlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRpivpnpgqlrqLyefelrllkesdl
0049772 (Phosphotyrosine protein) phosphatases II 18-132 4e-12 42.0 In-house 152-250 (314) alignment 
Range on Protein: 18-132
Range on HMM: 152-250/314.0
SLYRsGYPMPLNYSFIKhqlhlktiiyigdkdrplEEY--QSFLESEKIKYYHIFMDSsRDEGIQERMNQVLHLVLDV-RNYPILVHSNKGKHRVG--VV
. .  ..| . .. ..|                  ||.  ....| . |||..| ..   .. . | ....|...... ...|.||| . ||.| |  ||
dgng.neptaadlellk..................eelydpelferlgikylripvpD.gsaplledfdeflefieeadkggpvlvHCkaGkgRtgtfvv

VGIIRKLLqGWSTAGICQEY
.... ||| |.| . . ...
aaylmkll.gvsleealedv
0042113 (Phosphotyrosine protein) phosphatases II 5-138 5.8e-12 41.0 In-house 38-224 (245) alignment 
Range on Protein: 5-138
Range on HMM: 38-224/245.0
PPLNFSPV---VSTDVsLYRSGYPMPLNYS----FIKhQLHLKTIIYIGDKDRP----LEEY-----------------------------------QSF
.. |.|.|     |.  ......|.| ..     ... .|...||. . . .       ..|                                   ...
dyinasyvdgyritpk.fiatqgPlpetvedfwrmlw.elgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgdd

LESEKIKYYHIFMDSSR----DEGIQERMNQVLHLVLDVRNYPILVHSNKGKHRVGVVVGIIRK-----LLQGWSTAGICQEYGLFSGG
 . | | |... ..       .| ... .. |.. . . .|.|.|||.. |..| |..... .       ..|.|   . .|.  . .|
esrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpg
0036282 (Phosphotyrosine protein) phosphatases II 12-131 2.2e-11 39.2 In-house 13-141 (174) alignment 
Range on Protein: 12-131
Range on HMM: 13-141/174.0
VVSTDvSLYRSGYPMPlnYSFIKHQLHLKTIIYIGDKDRPL--------EEYQSFLESEKIKYYHIFMDSSRDEGIQErMNQVLHLVLDV----RNYPIL
.. |.  |.....|..  .    ..|...|..   .   .          |....|| . |.|... ..      ... . ... .| ..    .. |.|
syitp.rliagqgpla..fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvl

VHSNKGKHRVGVVVGIIRKLLQGW-STAGICQE
|| . |..| |..|.. . | ... |.  ... 
VHCsaGvgRtGtlvaaylmlrglleslvdaldl
0041856 (Phosphotyrosine protein) phosphatases II 18-135 1.4e-10 36.6 In-house 25-149 (182) alignment 
Range on Protein: 18-135
Range on HMM: 25-149/182.0
SLYRSGYPM--------------PLNYSFIKHQlHLKTIIYIGdkdrPLEEYQSFLESEKIKYYHIFMDSSRDEGiQERMNQVLHLVLDvRNYPILVHSN
.||....|               . .. ..|.. . .||. .     .   . ..|| . |.|......        . ... .. ||. .. |.||| .
nlylgslpatrfiatqgpllstvadflrmlkel.gittivnlt....eelywpellerlgiqylylpwpDhgvpd.ldelldfieevle.eggpvlVHCs

KGKHRVGVVVGIIRKLLQGWSTAGICQEYGLF
 |..| |..|..   . .|.|   . ...   
aGvgRtgtlvaaylmkklgvsleeavklvrsr
0040438 (Phosphotyrosine protein) phosphatases II 35-136 7.3e-10 34.1 In-house 107-255 (317) alignment 
Range on Protein: 35-136
Range on HMM: 107-255/317.0
HQLHLKTIIYIGDKDRPLE--------------------EYQSFLESEKIKYYHIFMDSS----------------RDEGIQERMNQVLHLVLDVR----
.......|. . . . .                      ...|. | . |..... .  .                 | |. . ....|...  ||    
weqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale

--NYPILVHSNKGKHRVGVVVGIIRK-----LLQGWSTAGICQEYGLFS
  . |.|||.. |..| |..... .        .|..   . .|.  . 
dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqR
0037934 (Phosphotyrosine protein) phosphatases II 6-133 9.4e-10 33.9 In-house 36-217 (243) alignment 
Range on Protein: 6-133
Range on HMM: 36-217/243.0
PLNFSPVVStdvSLYRSGYPMPL--------NYSFIKHQlHLKTIIYIGDKD----RPLEEY----------------------------------QSFL
..|...|.     |.....|.|         .. ..... . ..|. . . .       ..|                                   . |
nanliyvtp...rliatqgPlpetveddlasfwrmlwel.gitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddl

ESEKIKYYHIFMDS----SRDEGIQERMNQVLHLVLD-------VRNYPILVHSNKGKHRVGVVVGIIRKLLQ-GWSTAGICQEYG
. . |.|... .      .  | ... ...|   . .        .. |.|||   |..| |... .   ||. |..   . ... 
trlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllr
0040439 (Phosphotyrosine protein) phosphatases II 35-134 7.4e-09 31.1 In-house 75-223 (249) alignment 
Range on Protein: 35-134
Range on HMM: 75-223/249.0
HQLHLKTIIYIGDKDRP-------------------------------------LEEYQSfLESEKIKYYHIFMDSSRDEGIQERMNQVLHLVLDV----
..|. ..|. . . ...                                     || . .  ..|.....|| . .  | |. . ....| ..  |    
welgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkal

----RNYPILVHSNKGKHRVGVVVGIIRK-----LLQGWSTAGICQEYGL
    .. |.|||.. |..| |.....          .|..   . ...  
eelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrs
0043336 (Phosphotyrosine protein) phosphatases II 21-139 1.5e-08 29.9 In-house 92-259 (278) alignment 
Range on Protein: 21-139
Range on HMM: 92-259/278.0
RSGYPMPLN----YSFIKhQLHLKTIIYIGDKDRPL------------------------------------EEYQsFLESEKIKYYHIFMDSSRDEGIQ
....|.| .    . ... .|. .||. . . .                                       |      ..|. . .|.   .  | |. 
atqgPlpetvedFwrmvw.elgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtn.lgdgesrtvthyhylgwpdhgvp

ERMNQVLHLVLDV------RNYPILVHSNKGKHRVGVVVGIIRK-----LLQGWSTAGICQEYGLFSGGM
| ....|... .|      .| |.|||.. |..| |..... .        .|..   . .|.  . .|.
eslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpga
0045450 (Phosphotyrosine protein) phosphatases II 16-130 6.7e-08 28.1 In-house 95-277 (307) alignment 
Range on Protein: 16-130
Range on HMM: 95-277/307.0
DVSLYRSGYPMPLNY---------------SFIKHQlHLKTIIYIGDKDRPLE---------------------EYQSFLESEKIKYYHIFMDSS-----
.. |...||  ....                ....| . ..|. . . .                         .. |. . ........ .  .     
pllllldgydlkrkfIatqgPlpetvedFwrmlweq.gvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtge

------------RDEGIQERMNQVLHLVLDV--------RNYPILVHSNKGKHRVGVVVGIIRKLLQG--------WSTAGICQ
             | |. . ....|...  |        .. |.|||.. |. | |.....   | |.        ..   . .
srtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavk
0039614 (Phosphotyrosine protein) phosphatases II 36-137 2.3e-07 26.0 In-house 123-269 (297) alignment 
Range on Protein: 36-137
Range on HMM: 123-269/297.0
QLHLKTIIYIGDKDRPLE------------------EYQSFLESEKIKYYHI--------------FMDSSRDEGIQERMNQVLHLVLDV--------RN
... ..|. . . .                      .. .. . . ......                 .  | |. . ....|...  |        ..
eqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkg

YPILVHSNKGKHRVGVVVGIIRK-----LLQGWSTAGICQEYGLFSG
 |.|||.. |..| |..... .        .|..   . .|.    .
gpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRp
Y_phosphatase3 Tyrosine phosphatase family 64-133 2.6e-07 25.8 Pfam-A 99-161 (164) alignment 
Range on Protein: 64-133
Range on HMM: 99-161/164.0
IKYYHIFMDSSrdegiQERMNQVLHLVLDVRNyPILVHSNKGKHRVGVVVGIIRKLLqGWSTAGICQEYG
 ..|. .....     ......||..... .. |.|.|   || | |||. .. .|| | . . | ..| 
aeayreilede.....kkayrkvlealaeeeg.pvlfHCtaGKDRTGvvaalllsll.gvdeetiaaDYl
0045098 (Phosphotyrosine protein) phosphatases II 23-135 1.8e-06 23.1 In-house 33-249 (278) alignment 
Range on Protein: 23-135
Range on HMM: 33-249/278.0
GYP-----------------------------------------MPLNYSFIKHQlHLKTIIYIGDKDRP------------------------------
...                                         .  .. ..... . ..|. . .                                  
nldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwel.gitvivmltelvelgrekcaqywpeggsltygdftvtllseevl

------------LEEYQSFLESEKIKYYHI-FMDSSRDEGIQ--ERMNQVLHLVLD----------------VRNYPILVHSNKGKHRVGVVVGIIRKLL
            |  ... ||| .....|. ...            . ..|  ...                 .. |.||| . |..| |..|..   | 
ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmle

Q---GWSTAGICQEYGLF
.   |..   . .|.   
lleggvdlleavkelrsq
0046845 (Phosphotyrosine protein) phosphatases II 60-128 3.3e-06 22.2 In-house 161-245 (284) alignment 
Range on Protein: 60-128
Range on HMM: 161-245/284.0
ESEKIKYYHIFMDSSRDEGIQERMNQVLHLVLDVRNY--------PILVHSNKGKHRVGVVVGIIRKLLQ--------GWSTAGI
..| .. .|. . |  | |. . ....|... .||..        ||.||.  |. | |... .   | |        |..  ..
tgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvlea
0036941 (Phosphotyrosine protein) phosphatases II 60-119 3.7e-06 21.9 In-house 164-231 (297) alignment 
Range on Protein: 60-119
Range on HMM: 164-231/297.0
ESEKIKYYHIFMDSSRDEGIQERMNQVLHLVLDVRN--------YPILVHSNKGKHRVGVVVGIIRKL
..|. . .|. . .  | |. | ....|...  ||.         |.|||.. |..| |.....   |
ngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlml
DUF2608 Protein of unknown function (DUF2608) 28-70 4.2e-06 13.8 Pfam-A 167-209 (253) alignment 
Range on Protein: 28-70
Range on HMM: 167-209/253.0
LNYSFIKHQLHLKTIIYIGDKDRPLEEYQSFLESEKIKYYHIF
| | ..| . . |.||.. |. . ||  ...... .|... |.
LkylLaktnkspkkIifvddskenlesmeeackkaninflGih
0051299 (Phosphotyrosine protein) phosphatases II 59-119 6.6e-06 21.3 In-house 177-243 (288) alignment 
Range on Protein: 59-119
Range on HMM: 177-243/288.0
LESEKIKYYHIFMDSSRDEGIQERMNQVLHLVLDVRNY------PILVHSNKGKHRVGVVVGIIRKL
 ..|.....|. . .  | |. . ....|... .||..      |..||.. |. | |... .   |
gdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdlll