Gene OCA1 in Saccharomyces cerevisiae

Synonym: YNL099C, OCA1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family OCA
Subfamily OCA
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP058_AA protein Get Run
ScerP058_AA_44-204 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Y_phosphatase2 Tyrosine phosphatase family 67-234 1e-62 202.8 Pfam-A 1-163 (165) alignment 
Range on Protein: 67-234
Range on HMM: 1-163/165.0
IVPPLNFCPVERYLYRSGQPSPVNFPFLLNLKLKTIIWLSNE-EPQDTLLeFCDTHRINLQFAAINPDAGEddnpWDGLTEHSIINVLQTIVTQENYPLL
.||||||..||..||||..|...||.|| .|||||||.||.| |.||.|  |.....|.|...||. ...|    .  ...... ..|......||||.|
lvpplnFsaveselyrssyprasnfsflksLkLktiislspeeesqdelq.fleeekiklyhiaiesnkee....lveiksdllkkalklllnkenypvl

VCCGMGRHRTGTVIGCLRRIMGWNLASVSEEYRRFTGSrGGRILVELLIEAFDTNLVKIDKNKAPSWLL
..| .|.||||.||||||....|.|||...|||||.||   ||. | .||.||..|.. .|||....| 
lhckrGkhrtglvigclRklqkWslasilnEyrrFsgs.kkrivdeefienfdselevekknkklkvlk
subfamily_OCA_pd Subfamily OCA 46-218 2.3e-36 115.6 In-house 123-282 (282) alignment 
Range on Protein: 46-218
Range on HMM: 123-282/282.0
INEETESGREKVLVSHAPQERIVPPLNFCPVER--------YLYRSGQPSPVNFPFL-LNLKLKTIIWLSNEE-PQDTLLEFCDTHRINLQFAAInpdag
.. ...... ............|||.||. ||.         |.|...|.. |.|||  .|.|||...|..|| ...|. .|.....|.|.  .      
vmfllpidkifgthffprlyslvpprnfslveeykdkpvisgllrlllpeeenlpfLidrlglktaliLdaeeveretiadflasseiklvslrn.....

eddnpwdgltehsiiNVLQTIVTQENYPLLVCCgmgRHRTGTVIGCLRRIMGWNLASVSEEYRRFTGSRGGRILVELLIEAFD
               .||.......||.....|   ...|.||...||... ....|  .||..||.    ..  .|||| ||
...............evlkdlldndnyavelsc...qaktdtvlkvLrkdkkygstsiyleyigFtledqeslksillielfd
0051082 (Phosphotyrosine protein) phosphatases II 67-202 3.5e-28 93.5 In-house 2-133 (151) alignment 
Range on Protein: 67-202
Range on HMM: 2-133/151.0
IVPPLNFCPVERYLYRSGQPSPVNFPFLLNLKLKTIIWLSNEEPQDTLLEFCDTHRINLQFAAINPDAGEDdnpwDGLTEHSIINVLQTIVTQENYPLLV
.....||  |. .|||||.|.. ....| .|..|||. | .||. ... |..  . |..    |  .   .      |. ......|. .  ..|.|.||
lsdyinfsyvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpg....lplsfdavleflellldkkngpvlv

CCGMGRHRTGTVIGCLRRIMGWNLASVSEEYRRFTG
 | .|..||||...... ..|..|... ||||.. .
HCsaGkgRTGtlvalylmllgvsleealeeyrlkrp
0051429 (Phosphotyrosine protein) phosphatases II 71-201 2.8e-22 75.1 In-house 15-190 (272) alignment 
Range on Protein: 71-201
Range on HMM: 15-190/272.0
LNFCPVERYLYRSGQP---SPVNFPFLLNLKLKTIIWLSNEEPQDTLLEFCDTHRINLQFAAINPDAGEDDN----------------------------
..   ....|||||.|   .. .|..| .|..|||. | .|| .. |  ..  . |.. .  |..|. .. .                            
ygrvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlll

----------------PWDGLTEHSIINVLQTIVTqeNYPLLVCCGMGRHRTGTVIGCLRRIMGWNLASVSEEYRRFT
                | .|  .......|. . .  ..|.|| |  |..|||||. .|. ..|..|  . ..|....
sagearevmhlhytdwpdhgvpqeallellellld..ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltn
0042113 (Phosphotyrosine protein) phosphatases II 57-200 1.8e-19 65.6 In-house 26-221 (245) alignment 
Range on Protein: 57-200
Range on HMM: 26-221/245.0
VLVSHAPQERIVPPLNFCPV-----ERYLYRSGQPSPVNFP----FLLNLKLKTIIWLSNEEPQDTL---------------------------------
| .|. . .  ... |...|      . ......|.| ...    .| .|...||..|..||. .                                   
vklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvr

---LE--FCDTHRINLQFAAINPDagEDDNPWDGLTEHSIINVLQTIVT-QENYPLLVCCGMGRHRTGTVIGCLR------RIMGWNLASVSEEYRRF
   ..   .| .| ....  .. .  ... |..  .  .... .....   .|.|.|| | .|..||||.|....      . .|..| .. .|.|..
tlevtnlgddesrevihyhylpwp..dhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsq
0044763 (Phosphotyrosine protein) phosphatases II 58-199 1.3e-17 59.5 In-house 8-149 (178) alignment 
Range on Protein: 58-199
Range on HMM: 8-149/178.0
LVSHAPQERIVPPLNFCPVERYLYRSGQPSPVNFPFLLNLKLKTIIWLSNEEP---QDTLLEFCDTHRINLQFAAINpDAGEDDnpwDGLTEHSIINVLQ
|.|. ...  ....|.. .  .||....|.. ....| .|....|. |..| .   .... .... . |. ..  |  | |. |        . ... ..
llsnleglersdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipip.Dhgvpd...llehflefvefie

TIVTQENYPLLVCCGMGRHRTGTVIGC-LRRIMGWNLASVSEEYRR
... ... | ||.| .|..|.||.. . | . .|..| .. |..|.
ealdekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvre
0048076 (Phosphotyrosine protein) phosphatases II 70-200 5.2e-17 57.3 In-house 1-121 (145) alignment 
Range on Protein: 70-200
Range on HMM: 1-121/145.0
PLNFCPVERYLYRSGQPSPVNFPFLLNLKLKTIIWLSNEEPQDTllefcdTHRINLQFAAInPDAGEDDNPWDgltEHSIINVLQTIVtQENYPLLVCCG
| ... .  .||....|.......| .|...|.. |..|..  .       . |....  . || |. | . .     .... ..... .|..| ||.| 
pywpseilpglylgslptaldlellkdlgittvlnltselelle......rlgiqylylpw.pDhgvpdllel...lleflefieeal.keggpvlVHCs

MGRHRTGTVIGC-LRRIMGWNLASVSEEYRRF
.|..||||.... | . .|..| .. |..|. 
aGvgRtgtlvaaylmlllgvsleealelvrsq
0048179 (Phosphotyrosine protein) phosphatases II 72-200 5.6e-17 57.3 In-house 3-123 (144) alignment 
Range on Protein: 72-200
Range on HMM: 3-123/144.0
NFCPVERYLYRSGQPSPVNFPFLLNLKLKTIIWLSNEEPQDTLLEFcdthriNLQFAAIN-PDAGEDDNPwdgLTEHSIINVLQTIVTqENYPLLVCCGM
|.. .  .||....|.......| .|...|.| |..| ... |  .      ..|.  .. || |  | .       .... .....  |..| ||.| .
npseilpglylgslptaldlellkklgittvinlteeyepeflere......giqylhlpwpDhgvpdll...ellleflefieeale.eggpvlVHCsa

GRHRTGTVIGC-LRRIMGWNLASVSEEYRRF
|..||||.. . | . .|..| .. ...|. 
GvgRtgtlvaaylmkklglsleealalvrsr
0049772 (Phosphotyrosine protein) phosphatases II 45-202 2.8e-13 45.7 In-house 74-255 (314) alignment 
Range on Protein: 45-202
Range on HMM: 74-255/314.0
YINEETESGREKVLVSHAPQERIVPPL-----------------------------------------------NFCPVERYlyrsGQPSPVNFPFLLnl
|||    .|  | ... .| |  |  .                                               .  . ...    ..|.. ....|   
yinasyvdgflkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng....neptaadlellk..

klktiiwlsneePQDTLLEFCDTHRINLQFAAInpdageDDNPWDglTEHSIINVLQTIVT-QENYPLLVCCGMGRHRTG--TVIGCLRRIMGWNLASVS
            .  .  |..  . |..    .      .|. ..  ..  .  .|. | . ....|.||.| .|..|||   |...| . .|..|. . 
............eelydpelferlgikylripv......pDgsap..lledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleeal

EEYRRFTG
|..|.   
edvrlkRp
0036282 (Phosphotyrosine protein) phosphatases II 69-204 4.2e-13 44.8 In-house 8-146 (174) alignment 
Range on Protein: 69-204
Range on HMM: 8-146/174.0
PPLNFCPVERYLYRSGQPSPvNFPFLLNLKLKTIIWLSNEEPQD---------TLLEFCDTHRINLQFAAINpdageDDNPWDGLTEHSIINVLQTIVTQ
.||..  . ..|.... | . ....| .|...|.. | .|.. .         .| |..  . |....  .      |... |  . ..... ..... .
spldlsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwp.....Dhgvpdlsillefvkfveealse

-ENYPLLVCCGMGRHRTGTVIGCLRRIMGWNlASVSEEYRRFTGSR
 .. |.|| | .|..||||...... ..|.   |. . .. .   |
dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelR
0041856 (Phosphotyrosine protein) phosphatases II 70-199 4.6e-13 44.6 In-house 16-148 (182) alignment 
Range on Protein: 70-199
Range on HMM: 16-148/182.0
PLNFCPVERYLYRSGQPS--------------PVNFPFLLNLKLKTIIWLSneepqD--TLLEFCdtHRINLQFAAIN-PDAGEDDnpwdgltEHSIINV
..... .  .||....|.              . ....| .|. .||. |.     .     |..  .| ..|.  .. || |  |        ..... 
srdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.....eelywpell..erlgiqylylpwpDhgvpd.......ldelldf

LQTIVTqENYPLLVCCGMGRHRTGTVIGC-LRRIMGWNLASVSEEYRR
....   |. | || | .|..||||.... | . .|..| .. ...|.
ieevle.eggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrs
0037934 (Phosphotyrosine protein) phosphatases II 66-199 2.5e-11 39.1 In-house 32-218 (243) alignment 
Range on Protein: 66-199
Range on HMM: 32-218/243.0
RIVPPLNFCPVERYLYRSGQPSPV--------NFPFLLNLKLKTIIWLSNEE--------------------------------------------PQDT
    ..|...| ..|.....| |         .. .| .|. ..|. | ...                                            ..| 
sdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddl

LLEFCDTHRINLQfaainpDAGEDDNPWDGLTEHSIINVLQTI-----VTQENYPLLVCCGMGRHRTGTVIGCLRRIM--GWNLASVSEEYRR
 .. .  |...        | |  |.| | |  .....  .       .  .. |.|| | .|..||||.| ..  ..  |..| .. ...|.
trlvihyhylpwp......dhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllre
0043336 (Phosphotyrosine protein) phosphatases II 76-200 1.4e-10 36.6 In-house 62-255 (278) alignment 
Range on Protein: 76-200
Range on HMM: 62-255/278.0
V------------------------ERYLYRSGQPSPVN----FPFLLNLKLKTIIWLSNEEPQDT----------------------------------
|                         |  .... |.| .    . .. .|. .||. | ...  .                                   
vklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrt

---LLEFCDTHRINLQFAAINPDagEDDNPWDGLTEHSIINVLQTIVTQENYPLLVCCGMGRHRTGTVIGCLR------RIMGWNLASVSEEYRRF
       ..  |. ...  ..    ... | .  .  ..........  .| |.|| |  | .||||.|....      .. |..| .. .|.|..
levtnlgdgesrtvthyhylgwp..dhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreq
0039614 (Phosphotyrosine protein) phosphatases II 70-199 1.7e-09 33.0 In-house 67-266 (297) alignment 
Range on Protein: 70-199
Range on HMM: 67-266/297.0
PLNFCPV--------------------------ERYLYRSGQPSPVN----FPFLLNLKLKTIIWLSNEEPQD-------------------TLLEFCDT
|.... |                           |  .... |.| .    . .. ... ..|. | .... .                   |||..   
pydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehl

HRIN-----------------LQFAAINpdagEDDNPWDGLTEHSIINVLQTIVTQ--ENYPLLVCCGMGRHRTGTVIGCLR------RIMGWNLASVSE
. ..                 .|.  .     ... | .  .  .... ..... .  .. | || | .| .||||.|....      .  |... .. .
dgytvrtlevtnngesrtvthfqytgwp....dhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavk

EYRR
|.|.
elre
0040439 (Phosphotyrosine protein) phosphatases II 68-199 1.8e-09 33.0 In-house 20-223 (249) alignment 
Range on Protein: 68-199
Range on HMM: 20-223/249.0
VPPLNFCPVERYLYRSGQPS----------------------------PVNFPFLLNLKLKTIIWLSNEEPQDTLLE-----------------------
..|.... |    .... .|                            . .. .| .|. ..|. |..... .                           
ilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsve

---------------FCDTHRINLQFAAINPDagEDDNPWDGLTEHSIINVLQTIVTQ--ENYPLLVCCGMGRHRTGTVIGCLR------RIMGWNLASV
                ....|  |..  ..    ... | .  .  ..|. .......  .. |.|| | .| .||||.|...       .  |..| ..
vkddytvrtleltnlydgesrtvlhiqytdwp..dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleea

SEEYRR
 ...|.
vkllrs
0045098 (Phosphotyrosine protein) phosphatases II 63-199 1.9e-09 32.8 In-house 12-248 (278) alignment 
Range on Protein: 63-199
Range on HMM: 12-248/278.0
PQERIVPPLNFCPVERYLYRSGQP-----------------------------------------SPVNFPFLLNLKLKTIIWLSNEEPQD---------
  |..... ... .. .||.....                                            .. .| .|. ..|. | .... .         
efefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp

------------------------------TLL----EFCDTHRINLQFAAINPDAGEDDNP--WDGLTEHSIINVLQT----------IVTQENYPLLV
                              | |    | . .. ..       || |  ..|  .  |     |.  .           .. ... | ||
eggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlV

CCGMGRHRTGTVIGCLRRIM----GWNLASVSEEYRR
 | .| .||||....   .     |..| .. .|.|.
HCsaGvgRtGtlvaaylmlelleggvdlleavkelrs
0040438 (Phosphotyrosine protein) phosphatases II 92-200 2.4e-09 32.4 In-house 104-254 (317) alignment 
Range on Protein: 92-200
Range on HMM: 104-254/317.0
PFLLNLKLKTIIWLSNEEPQD---------------------TLL-EF----------------CDTHRINLQFAAIN-PdagEDDNPWDGLTEHSIINV
 .. ......|. | ..|. .                     ||| |.                ....|.. .|  .. |   ... | .  .  .... 
rmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWp...dhgvppspdllldflea

LQTIVTQENYPLLVCCGMGRHRTGTVIGCLR------RIMGWNLASVSEEYRRF
...   ... |.|| | .| .||||.|....      . .|... .. .|.|..
vrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreq
0045450 (Phosphotyrosine protein) phosphatases II 72-199 4.1e-08 28.8 In-house 90-281 (307) alignment 
Range on Protein: 72-199
Range on HMM: 90-281/307.0
NFCPVERYLYRSGQPSPVNF---------------PFLLNLKLKTIIWLSNEEPQDTL-------------------------------------L---E
..  | ..|...|  .. .|                .| ... ..|. |..... .                                       .   .
syvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdld

FCDTHRINLQFAAINPDagEDDNPWDGLTEHSIINVLQTIVTQ--ENYPLLVCCGMGRHRTGTVIGCLRRIMG---------WNLASVSEEYRR
... .|.  .|  ..    ... | .  .  ..|. ..... .  .. | || | .|  ||||.|...  . .         ..| .. ...|.
gtgesrtvthfhytgwp..dhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllre
0046846 (Phosphotyrosine protein) phosphatases II 68-199 8.8e-08 27.6 In-house 7-149 (176) alignment 
Range on Protein: 68-199
Range on HMM: 7-149/176.0
VPPLNFCPVERYLYRSGQP----------SPVNFPFLLNLKLKTIIWLSNEEPQD-----TLLEFcdTHRINLQFAAINPDAGedDNPWDgLTEHSIINV
...|..  .  .|. .. |           . .. .|..|. .... | .|   .     .. .    .. ..|.  .. . .  . | .    ..... 
gldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgiqylhlpwpDh..gvpdl.elllellef

LQTIVTQEnYPLLVCCGMGRHRTGTVIGCLRRIM--GWNLASVSEEYRR
... ...   | || | .|. ||||.. ..  .   |...  . ...|.
irealkeg.gpvlVHCsaGigRtgtlvaayllelekglsveealalvre
0049260 (Phosphotyrosine protein) phosphatases II 79-198 1.5e-07 26.8 In-house 14-126 (152) alignment 
Range on Protein: 79-198
Range on HMM: 14-126/152.0
YLYRSGQPSPVNFPFLLNLKLKTIIWLSNEEPQDTLLEFCDTHRINLQFaainPDAGeddNPWDGLTEHSIINVLQTIVTQENYPLLVCCGMGRHRTGTV
...  ... . .. .| .|. .||..| .... . | .    . ..|..    || |    | .      .. ... .  ... | || |  |  ||||.
tqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpw....pDhg...vpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtl

IGCLRRIMGWNLASVSEEYR
. ..  ..|..|  . . .|
vaaylmllgvsleeavalvr
0043147 (Phosphotyrosine protein) phosphatases II 84-199 2.7e-07 26.0 In-house 30-138 (172) alignment 
Range on Protein: 84-199
Range on HMM: 30-138/172.0
GQPSPVNFPFLLNLKLKTIIWLSNEEPQDTLLEFCDTHRINLQFAainpdageDDNPWDGLTEHSIINVLQT-IVTQENYPLLVCCGMGRHRTGTVIGCL
. . . .. .| .|. ..|. | ...   .|||  . . . | .         | .. .     .... ... .. ... | || | .|  ||||.. ..
rntladfwrmlkelgithivnltellydpellerlgiqylylpwp........DhgvpllellleflefidellalspggpvlVHCsaGvgRtgtlvaay

RRIMGWNLASVSEEYRR
  ..|..|  . ...|.
lmllglsleeavalvre
Y_phosphatase3 Tyrosine phosphatase family 147-198 1.1e-06 23.8 Pfam-A 111-161 (164) alignment 
Range on Protein: 147-198
Range on HMM: 111-161/164.0
HSIINVLQTIVTQENyPLLVCCGMGRHRTGTVIGCLRRIMGWNLASVSEEYR
... .||... ..|. |.|. | .|. ||| |.  | ...| . . . ..| 
kayrkvlealaeeeg.pvlfHCtaGKDRTGvvaalllsllgvdeetiaaDYl