Gene TEP1 in Saccharomyces cerevisiae

Synonym: YNL128W, TEP1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily PTEN
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP061_AA protein Get Run
ScerP061_AA_20-254 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTEN_pd Subfamily PTEN 23-256 3.9e-67 220.8 In-house 2-183 (184) alignment 
Range on Protein: 23-256
Range on HMM: 2-183/184.0
MKKILSLPMKKTKNDiGLRLDISYILVNLIVCSYPVnTYPKLLYRNSLDDLILFLTVYHgKGNFRIFNFRGEKedsdykdndligiaaKFESKDFeiqel
..||.| ..|..|.| ||.||.|||. |.|...||. .... ||||||.|.. ||. .| |....|.|.|.|.               |..||.|     
lrkivskkkkrfked.gldLDlsyiteniiamgyPa.eklealyRnsledvvkflekkh.kdhykiynlrser...............kydskkf.....

rstlinDGKIPISPIDletrtlveeetnnvicerigwlDHFPPPFELLEEIVDGIENYLSVSKNRVAVLHCRMGKGRSGMITVAYLMKYLQCPLG-EARL
      ||.....|.|                      ||.|||.|||||||. ||..|...|..|.|.||..||||.|...||||.|.|...   ||. 
......dgrvavypfd......................DhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeeale

IFMQARFKYGmtNGVTIPSQLRYLRYHEFFITHEK
.|..||.|..  .|||||||.||..|.|.....||
lfaeaRtknk..kgvtiPsqrRYveYyeklleeek
0036282 (Phosphotyrosine protein) phosphatases II 42-251 1e-27 92.3 In-house 10-168 (174) alignment 
Range on Protein: 42-251
Range on HMM: 10-168/174.0
LDISYILVNLIVCSYPVNtYPKLLYRNSLDDLILFLTVYHgKGNFRIFNFRGEkedsdykdndligiaakfeskdfeiqelrstlindgkipispidlet
||.|||. .||....| . . ..|..... ... .|. .. .|.....|.  |                                               
ldlsyitprliagqgpla.fwemlkelgittvvmlleeke.lglykcinywpe...............................................

rTLVEEETNNVICERIGWLDHFPPPFELLEEIVDGIENYLSVSKNRVAVLHCRMGKGRSGMITVAYLMKYLQC-PLGEARLIFMQARFKygMTNGVTIPS
 .   .| ...   ...| || .|... |.|.|. .|..|| ..... . ||..|.||.|.. .||||..... .| .|  .. ..|..    ..|..||
.lredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlq..rpgmvqtps

QLRYLRYHEFF
|.|.|.|.| .
Qyrflyyfekl
0041856 (Phosphotyrosine protein) phosphatases II 41-254 5.3e-25 83.5 In-house 16-172 (182) alignment 
Range on Protein: 41-254
Range on HMM: 16-172/182.0
RLDISYILVNLIVCSYPVNTYPkLLYRNSLDDLILFLTVYHGKGNFRIFNFRGEKEDSDYKdndligiaakfeskdfeiqelrstlindgkipispidle
 .|..||. ||...|.| ...  . ... |...  ||. ... |   | | ..|  . ..                                        
srdldyInanlylgslpatrfi.atqgpllstvadflrmlkelgittivnlteelywpell.......................................

trtlveeETNNVICERIGWLDHFPPPFELLEEIVDGIENylsvsKNRVAVLHCRMGKGRSGMITVAYLMKYLQCPLGEARLIFMQARFKygmtnGVTIPS
       | ...   ...| || .|... | .... ...     .... . ||..|.||.|.. .|||||.|...| ||   . ..|..     .|..|.
.......erlgiqylylpwpDhgvpdldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpg.....mvitpn

QLRYLRYHEFFITH
|...|.. .... .
qyfflqlallelll
0037934 (Phosphotyrosine protein) phosphatases II 28-251 2.5e-24 81.6 In-house 6-240 (243) alignment 
Range on Protein: 28-251
Range on HMM: 6-240/243.0
SLPMKKTKN-----------------DIGLRLDISYILVNLIVCSYPVNTypkllyrNSLDDLILFLTVYHGKGNFRIFNFRGEKEDSDYKDNDLIGiaA
.||. ..||                 .  . .. .|.. .||....| .        .  |||  |.   .  |   | ... ..| . .|   .     
llpenlsknrysdilpydhsrvklegsdyinanliyvtprliatqgPlpe.......tveddlasfwrmlwelgitvivmltelvElgrekcaqywp..g

KFESKDFEIQELRSTLINDgkIPISPIDLETRTLVEEETNNVICERIGWLDHFPPP-FELLEEIVDGIENYLSV-------SKNRVAVLHCRMGKGRSGM
... .||... | ..  .|  . .  . ||   | ... ...   ...| || .|. .| | ...| . ....        ..... ..||..|.||.|.
evtygdftvtllseehldd..ytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGt

ITVAYLMKYL-QCPLGEARLIFMQARFKygmtNGVTIPSQLRYLRYHEFF
. .||||..| ...| ||   . . |.      .|..|||.|.|.... .
liaaylmllllgvdleeavkllreqRpg....kavqtpsqyrflyealle
0044763 (Phosphotyrosine protein) phosphatases II 39-252 1.2e-23 79.1 In-house 18-170 (178) alignment 
Range on Protein: 39-252
Range on HMM: 18-170/178.0
GLRLDISYILVNLIVCSYPVNTYPKLLYRNSLDDLILFLTVYHGKGnFRIFNFR----Gekedsdykdndligiaakfeskdfeiqelrstlindgkipi
.  ...|.|| .|...|.|   ...||... .. .. . . ...   .  .       |                                         
sdyinaseilpglylgslppaddlellkelgithivnlteelelgf.lkcdpywpeeag.........................................

spidletrtlveeetnnVICERIGWLDHFPPP-FELLEEIVDGIENYLSVSKNRVAVlHCRMGKGRSGMITVAYLMKYLQCPLGEARLIFMQARfkygmT
                 .   .|.. || .|. .| ..|.|. ||..|. ....|.| ||..|.||||.. .|||||.|...| ||   . ..|      
.................iqylhipipDhgvpdllehflefvefieealdekggpvlV.HCsaGvgRsgtlvaaylmkklglsleeaielvrerR.....p

nGVTIPSQLRYLRYHEFFI
 .|. |.|||.|.. | ..
.ivpnpgqlrqLyefelrl
0043147 (Phosphotyrosine protein) phosphatases II 42-251 2.4e-22 74.9 In-house 13-159 (172) alignment 
Range on Protein: 42-251
Range on HMM: 13-159/172.0
LDISYILVNLIVCSYPvntypkllYRNSLDDLILFLTVYHGKGnfrIFNFRGEkedsdykdndligiaakfeskdfeiqelrstlindgkipispidleT
||..||  ..|.. .|        .|| |.| . .|  .. .    |.|  ..                                              .
ldlyyipdrfiatqgp........lrntladfwrmlkelgith...ivnltel..............................................l

RTLVEEETNNVICERIGWLDHFPPPFELLEEIVDGIENYLSVSKNRVAVLHCRMGKGRSGMITVAYLMKyLQCPLGEARLIFMQARfkygmTNGVTIPSQ
 .   .| ...   ...| || .|..|||.|... |...| .|.. . . ||..|.||.|.. .||||. |...| ||   . ..|      ..|..|||
ydpellerlgiqylylpwpDhgvpllellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.lglsleeavalvrekR.....pgavqnpsq

LRYLRYHEFF
.|.|.|.| .
yrflyyfekl
0049772 (Phosphotyrosine protein) phosphatases II 148-251 7.8e-22 73.8 In-house 177-276 (314) alignment 
Range on Protein: 148-251
Range on HMM: 177-276/314.0
ETNNVICERIGWLDHFPPPFELLEEIVDGIENYlsvSKNRVAVLHCRMGKGRSG-MITVAYLMKYLQCPLGEARLIFMQARFkyGMTNGVTIPSQLRYLR
| ...   || . |. .|..| ..|... ||..   .|... . ||..||||.| ....|||||.|...| ||   ....|.     | ..|.....|. 
erlgikylripvpDgsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp..inpnpgfieqleqyef

YHEFF
..|. 
ileal
0046846 (Phosphotyrosine protein) phosphatases II 39-250 3.7e-21 71.1 In-house 7-170 (176) alignment 
Range on Protein: 39-250
Range on HMM: 7-170/176.0
GLRLDISYILVNLIVCSYPVNTYPKLlyrnsLDDLILFLTVYHGKGNFRIFNFRGEKEDSDYKDNDLIGIAAKFESkdfeiqelrstlindgkipispid
||.||..||. |||..|.|. |.  |      ..|  ||  ..  |   ..|.  |.| . .|  ..  .  |..                         
gldldldyinanlilgsrpiatqgpl.....prtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi........................

letrtlveeetnnvICERIGWLDHFPPPFELLEEIVDGIENYLSvsKNRVAVLHCRMGKGRSGMITVAYLMKY-LQCPLGEARLIFMQARFKygmtNGVT
                 ...| || .|..|||.|... |...|.  .... . ||..|.||.|.. .|||...  . .. ||   . . |..    . |.
..............qylhlpwpDhgvpdlelllellefirealk..eggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRpl....gavq

IPSQLRYLRYHEF
 |.|.|.|.. | 
tpeQyrflyefel
PTEN_1 144-250 2.9e-20 67.9 In-house 87-190 (196) alignment 
Range on Protein: 144-250
Range on HMM: 87-190/196.0
LVEEETNNVICERIGWLDHFPPPFELLEEIVDGIENYLSVSK-NRVAVLHCRMGKGRSGMITVAYLMKYLQCPLGEARLIFMQARFKYGMTngvtIPSQL
| |.. ..|.  .... || .|... | .|.. ....|.  . ..|.. ||. |.||||..  ||||.. .    ||  .. ..| . .      .||| 
leeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapn....spsqe

RYLRYHEF
|.|.| . 
rlleyfae
0048179 (Phosphotyrosine protein) phosphatases II 61-249 4.3e-19 64.1 In-house 8-141 (144) alignment 
Range on Protein: 61-249
Range on HMM: 8-141/144.0
YPKlLYRNSLDDLILFLTVYHgKGNFRIFNFRGEKEDSDYKDNdligiaakfeskdfeiqelrstlindgkipispidletrtlveeetnNVICERIGWL
.|. ||..|| ... . .  .  |   ..|.. | |  .....                                               ..   ...| 
lpg.lylgslptaldlellkk.lgittvinlteeyepeflere...............................................giqylhlpwp

DHFPPPF-ELLEEIVDGIENYLSvsKNRVAVLHCRMGKGRSGMITVAYLMKYLQCPLGEARLIFMQARFkygmtNGVTIPSQLRYLRYHE
|| .|.. |||.|... ||..|.  .... . ||..|.||.|.. .|||||.|...| ||   . ..|.     ..|. |.|||.|.. |
Dhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmkklglsleealalvrsrrp.....gavpnpgqlrfLleye
0039614 (Phosphotyrosine protein) phosphatases II 21-250 7.2e-18 60.5 In-house 45-286 (297) alignment 
Range on Protein: 21-250
Range on HMM: 45-286/297.0
NLMKKILSLPMKKTKN-----------------DIGLRLDISYI-----------LVNLIVCSYPVNTYP----KLLYRNSLDDLI--------------
.  ..|  ||  |.||                   |  || .||             . |....| .  .    ......    ..              
kpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaq

--------------LFLTVYHgKGNFRIFNFRGekedsdykdndligiaakfeskdfeiqelrsTLiNDgkipispidletrtlveEETNNVICERIGWL
               .|.|.| .... .....                                |  |.                 |.        .|| 
ywpeeggtygdftvtllkveh.ldgytvrtlev...............................tn.ng.................esrtvthfqytgwp

DHFPPP-FELLEEIVDGIENYLSVS-KNRVAVLHCRMGKGRSGMITVAYLM-----KYLQCPLGEARLIFMQARfkygmTNGVTIPSQLRYLRYHEF
|| .|| .||| |... ....|. . |... . || .|.||.|.. .||||     |. .  . ||   . ..|      ..|..|||.|.|.. ..
dhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqR.....pgavqtpsqyrflydall
0048076 (Phosphotyrosine protein) phosphatases II 147-250 7.9e-18 60.0 In-house 43-140 (145) alignment 
Range on Protein: 147-250
Range on HMM: 43-140/145.0
EETNNVICERIGWLDHFPPPF-ELLEEIVDGIENYLSvsKNRVAVLHCRMGKGRSGMITVAYLMKYLQCPLGEARLIFMQARFKygmtnGVTIPSQLRYL
.| ...   ...| || .|.. |||.|... ||..|.  .... . ||..|.||.|.. .||||..|...| ||   . ..|..     .|. |.|||.|
lerlgiqylylpwpDhgvpdllellleflefieealk..eggpvlVHCsaGvgRtgtlvaaylmlllgvsleealelvrsqrpg.....avpnpgqlrfl

RYHEF
.. | 
yefel
0038934 (Phosphotyrosine protein) phosphatases II 150-233 2.4e-17 58.7 In-house 78-157 (194) alignment 
Range on Protein: 150-233
Range on HMM: 78-157/194.0
NNVICERIGWLDH-FPPPFELLEEIVDGIENYLSVSKNRVAVLHCRMGKGRSGMITVAYLMKYLQCPLGEARLIFMQARfkygmT
...   .. . |. ..|..|.| ...| .. .|. ... | . || .|.||.|.. .|||...|.... ||  .| ..|      
agieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekR.....p
0042113 (Phosphotyrosine protein) phosphatases II 146-250 5e-17 57.6 In-house 135-240 (245) alignment 
Range on Protein: 146-250
Range on HMM: 135-240/245.0
EEETNNVICERIGWLDHFPPP-FELLEEIVDGIENYLSVSKNRVAVLHCRMGKGRSGMITVAYLM-----KYLQCPLGEARLIFMQARfkygmTNGVTIP
 |. ...   ...| || .|.  |||..... ....|. ..| . . ||..|.||.|.. .||||     |.|  .| ||   . . |      . |..|
desrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqR.....pgavqtp

SQLRYLRYHEF
||.|.|.. ..
sqyrflyeall
0049260 (Phosphotyrosine protein) phosphatases II 153-249 6.3e-17 57.1 In-house 56-146 (152) alignment 
Range on Protein: 153-249
Range on HMM: 56-146/152.0
ICERIGWLDHFPPPFELLEEIVDGIENYLSVSKNRVAVLHCRMGKGRSGMITVAYLMKyLQCPLGEARLIFMQARfkygmTNGVTIPSQLRYLRYHE
   .. | || .|... | ...  . . |  .|. . . ||. |.||.|.. .||||. |...| ||   . ..|      ..|. |.|||.| . |
qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.lgvsleeavalvrekR.....pgavpnpgqlrflyefe
subfamily_Tensin_pd Subfamily Tensin 155-253 1.1e-16 53.9 In-house 73-172 (189) alignment 
Range on Protein: 155-253
Range on HMM: 73-172/189.0
ERIGWLDHFPPPFELLEEIVDGIENYLSVSKNRVAVLHCRMGKGRSGMITVAYlMKYLQCPLGEARLI--FMQARFKYGMTNGVTIPSQLRYLRYHEFFI
  .|| |.  |..| |  |.  ....|.   ..|.|.||. |||| |..  || ||| .   ..   .  |   ||    ..|.| ||| ||..| . ..
ldfGWPdllaPsleklcsicksldsWlkadpqnvvvvhckGgkgrigvvvsay.mkyskisasadaaldrfamkrflddklsgetqPsqrryveyfsglL

T
.
s
0051082 (Phosphotyrosine protein) phosphatases II 42-249 8.4e-16 53.4 In-house 6-148 (151) alignment 
Range on Protein: 42-249
Range on HMM: 6-148/151.0
LDISYILVNLIVCSYPVNTYPKLLYRNSLDDLILFLTVYHGKGNFRIFNFRGekedsdykdndligiaakfeskdfeiqelrstlindgkipispidlet
...||.  .|.....| . . .||... ..  . . . .. . . ....  |                                                
infsyvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelg................................................

rtlveeetnnVICERIGWLDHFPPPFELLEEIVDGIENYLSVSKNRVAVLHCRMGKGRSGMITVAYLMKyLQCPLGEARLIFMQARFkygmtnGVTIPSQ
          .   .| .||. .|...|. ..|  . ..|   || . . ||..||||.|.. ..|||. |...| ||   ... |.      ||..|.|
..........ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylml.lgvsleealeeyrlkrp......gvvqpnq

LRYLRYHE
 ... ...
qflfqlfa
0045450 (Phosphotyrosine protein) phosphatases II 64-251 3.4e-15 52.0 In-house 160-302 (307) alignment 
Range on Protein: 64-251
Range on HMM: 160-302/307.0
LLYRNsldDLILFLTVYHgKGNFRIFNFRGEKEDS-DykdndligiaakfeskdfeiqelrstlindgkipispidletrtlveEETNNVICERIGWLDH
| |.|   . . .| ..| .... ..... .  |  .                                               |.    .   .|| ||
ltygn...ftvtllseeh.ldgytvrtlevtdldgtg...............................................esrtvthfhytgwpdh

FPPP-FELLEEIVDGIENYLSVS-KNRVAVLHCRMGKGRSGMITVAYLMKYLQ--------CPLGEARLIFMQARfkygmTNGVTIPSQLRYLRYHEFF
  || || | .... ....|. . |. . . ||..|.||.|.. .||||...         ..| ||   . . |      ..|. |.|.|.|.. ...
gvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqR.....pgavqnpeqyrflyealle
0036941 (Phosphotyrosine protein) phosphatases II 152-253 3.7e-15 51.4 In-house 171-277 (297) alignment 
Range on Protein: 152-253
Range on HMM: 171-277/297.0
VICERIGWLDHFPPP-FELLEEIVDGIENYLSVS-KNRVAVLHCRMGKGRSGMITVAYLM--------KYLQCPLGEARLIFMQARFKygmtnGVTIPSQ
 ..  .|| || .|. .. | .... ....|. . .. . . ||..|.||||.. .|.||        |. .... || . ... |.       |. ..|
thfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpg.....avqtleq

LRYLRYHEFFIT
.|.|.. ...  
yrflyeallell
0040438 (Phosphotyrosine protein) phosphatases II 151-254 1.6e-14 49.4 In-house 174-277 (317) alignment 
Range on Protein: 151-254
Range on HMM: 174-277/317.0
NVICERIGWLDHFPPP-FELLEEIVDGIENYLSvSKNRVAVLHCRMGKGRSGMITVAYLM-----KYLQCPLGEARLIFMQARfkygmTNGVTIPSQLRY
. .   .|| || .|| ..|| .... ....|. ... . . || .|.||.|.. .||||     |. .. . ||   . ..|      ..|. |.|.|.
vthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqR.....pgavqtpeqyrf

LRYHEFFITH
| . ....  
lydalleylk
0045098 (Phosphotyrosine protein) phosphatases II 151-250 2e-14 49.1 In-house 155-269 (278) alignment 
Range on Protein: 151-250
Range on HMM: 155-269/278.0
NVIC-ERIGWLDHFPPPFE---LLEEIVDGIENYLS------------VSKNRVAVLHCRMGKGRSGMITVAYLMKYL---QCPLGEARLIFMQARfkyg
.|     ..| || .|...    . |... |...|.             ... . . ||..|.||.|.. .||||..|   .. | ||   . . |    
gvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqR....

mTN-GVTIPSQLRYLRYHEF
  .  |....|.|.| . . 
.pglavqnleqyrflyefll
0043336 (Phosphotyrosine protein) phosphatases II 39-249 2.6e-14 48.8 In-house 68-273 (278) alignment 
Range on Protein: 39-249
Range on HMM: 68-273/278.0
GLRLDISYI----------LVNLIVCSYPVNTYPKLLyRNSLDD----------------------------------LILFLTVYHgKGNFRIFNFRGE
| .|| .||            . |....| .  ..   .. . .                                   . .| ..| .... ..... .
ggdldsdYinAsyvdgynvprkfiatqgPlpetvedF.wrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeeh.lddytvrtlevt

KEDSDykdndligiaakfeskdfeiqelrstlindgkipispidletrtlveEETNNVICERIGWLDHFPP-PFELLEEIVDGIENYLSvSKNRVAVLHC
.  ..                                               |.   ..   .|| ||  | ...|| ...  . ..|. ..| . . ||
nlgdg...............................................esrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHC

RMGKGRSGMITVAYLM-----KYLQCPLGEARLIFMQARfkygmTNGVTIPSQLRYLRYHE
. |.||.|.. ..||.     |..  .| ||   . . |      . |. |||.|.|.. .
saGvgRTGtfialyllleqlekeggvdleeavkelreqR.....pgavqtpsqyrflyeal
0040439 (Phosphotyrosine protein) phosphatases II 156-250 7.3e-14 47.4 In-house 147-243 (249) alignment 
Range on Protein: 156-250
Range on HMM: 147-243/249.0
RIGWLDHFPP-PFELLEEIVDGIENYLSVS-KNRVAVLHCRMGKGRSGMITVAYLM-----KYLQCPLGEARLIFMQARfkygmTNGVTIPSQLRYLRYH
 ..| ||  |  || | .... ....|.   |. . . || .|.||.|.. .||||     |.|. .| ||   . ..|      ..|. |.|.|.| . 
ytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqR.....pgavqnpeqyrflyea

EF
..
ll
0047943 (Phosphotyrosine protein) phosphatases II 156-247 6.4e-12 41.0 In-house 173-266 (273) alignment 
Range on Protein: 156-247
Range on HMM: 173-266/273.0
RIGWLDHFPP-PFELLEEIVDGIENYLSVS-KNRVAVLHCRMGKGRSGMITVAYLM-----KYLQCPLGEARLIFMQARFKygmtnGVTIPSQLRYLRY
  || ||  |  .| | |... ....|. . .| . | ||. |.||.|.. ...|.     |. .  . ||   . . |.      .|. |.|.|.| .
ytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpg.....mvqtpeqyrflye
0046845 (Phosphotyrosine protein) phosphatases II 145-248 9.7e-12 40.3 In-house 161-269 (284) alignment 
Range on Protein: 145-248
Range on HMM: 161-269/284.0
VEEETNNVICERIGWLDHFPPP-FELLEEIVDGIENYLSV-SKNRVAVLHCRMGKGRSGMITVAYLMKYL--------QCPLGEARLIFMQARfkygmTN
 .|.    .   ..| ||  || .| | |... ....|.  ... . | ||. |.||.|.. ...|....         ... ||   . . |      .
tgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqR.....pg

GVTIPSQLRYLRYH
 |. ..|.|.. . 
mvqtleqyrfvyea
PTPc_motif_SM00404 167-228 2.8e-11 38.5 In-house 63-122 (140) alignment 
Range on Protein: 167-228
Range on HMM: 63-122/140.0
FELLEEIVDGIENYlsVSKNRVAVLHCRMGKGRSGMITVAYLMKYLQCPLGEARLIFMQARF
.. |....| |||    .|..  . ||..|  ||.....||||.| |. | ||  .. . | 
skyldkvldfiena..ekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeayefvkerRp
subfamily_VSP_pd Subfamily VSP 154-251 2.9e-11 37.7 In-house 96-197 (212) alignment 
Range on Protein: 154-251
Range on HMM: 96-197/212.0
CERIGWLDHFPPPFELLEEIVDGIENYLSVSKNRVAVLHCRMGKGRSGMITVAYLMKYLQCPLGEARLIFMQAR-FKYG---MTNGVTIPSQLRYLRYHE
 .||   ||  | .| |  .   ....|.  ...| ..||. ||||.| |  |.|..  ..   .  | ..  |  ...   . .||  ||| ||. | |
vkriliddhnvpkleellvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgyle

FF
  
qv
DSPc Dual specificity phosphatase, catalytic domain 169-229 9e-11 36.8 Pfam-A 58-116 (133) alignment 
Range on Protein: 169-229
Range on HMM: 58-116/133.0
LLEEIVDGIENYlsVSKNRVAVLHCRMGKGRSGMITVAYLMKYLQCPLGEARLIFMQARFK
 |||.|. ||.    .|..  . ||..|  ||.....|||||. ...| ||  .. . | |
eleeavefieka..eqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerrsk
DSPc Dual specificity phosphatase, catalytic domain 169-229 9e-11 36.8 In-house 58-116 (133) alignment 
Range on Protein: 169-229
Range on HMM: 58-116/133.0
LLEEIVDGIENYlsVSKNRVAVLHCRMGKGRSGMITVAYLMKYLQCPLGEARLIFMQARFK
 |||.|. ||.    .|..  . ||..|  ||.....|||||. ...| ||  .. . | |
eleeavefieka..eqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerrsk
0051429 (Phosphotyrosine protein) phosphatases II 144-235 1.3e-10 36.9 In-house 115-212 (272) alignment 
Range on Protein: 144-235
Range on HMM: 115-212/272.0
LVEEETNNVICERIGWLDHFPPPfELLEEIVDGIENylsvskNRVAVLHCRMGKGRSGMITVAYLMKyLQCP--------------LGEARLIFMQARFK
  .|     .   ..|.||  |. | | |... . .      ..  . ||. ||.|.|.. ...|.  |. .              | ||.   ...| .
sagearevmhlhytdwpdhgvpq.eallellellld......ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpg

YGMTNG
.. | .
avqtee
0051299 (Phosphotyrosine protein) phosphatases II 155-245 4.9e-10 34.8 In-house 188-278 (288) alignment 
Range on Protein: 155-245
Range on HMM: 188-278/288.0
ERIGWLDHFPPP-FELLEEIVDGIENYLSvSKNRVAVLHCRMGKGRSGMITVAYLM-----KYLQCPLGEARLIFMQARFKygmtnGVTIPSQLRYL
  ..| ||  |. .||| ...  . ..|. |.. . | ||. |.||.|.. ...|.     |   . . ||   . . |.       |. |.|.|..
hytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpg.....mvqtpeqyrfv
subfamily_Auxilin_pd Subfamily Auxilin 142-248 2.5e-09 30.1 In-house 59-160 (166) alignment 
Range on Protein: 142-248
Range on HMM: 59-160/166.0
RTLVEEETNNVICErIGWLDHFPPPFELLEEIVDGIENYLSVSKNRVAVLHCRMGKGRSGMITVAYLMK--YLQCPlGEARLIFMQARFKYGmtngvTIP
||  ... .. . | .||  .  |. | | |.   . ..|   ...| |.||  |.  |... .|.|.    |. |  .|  .|.  |   |       |
rtyrtaklssrvve.agwparraPnLeslvevcrnlyswlkkdpknvvvvhckDGraasavlvsallvfcrllsep.esavrlfsvkrlpig.....lsp

SQLRYLRYH
|. ||| | 
sekryleyl
subfamily_PTPMT1_pd Subfamily PTPMT1 151-227 6e-09 30.6 In-house 73-148 (171) alignment 
Range on Protein: 151-227
Range on HMM: 73-148/171.0
NVICERIGWLDHF-PPPFELLEEIVDGIENYLSvSKNRVAVlHCRMGKGRSGMITVAYLMKYLQCPLGEARLIFMQAR
.|   ..   |..  | .| ||. |. ||.. | ...|| | ||. |.|||. .  .||||  .. . ||  .  . |
gveqlqlatvDfteapdleklekgvefiekvas.kgkrvYv.HCkaGrgRsatlvacylmkkeklspeeAlkalkkkR
subfamily_DSP12_pd Subfamily DSP12 169-231 1.7e-08 29.0 In-house 67-127 (155) alignment 
Range on Protein: 169-231
Range on HMM: 67-127/155.0
LLEEIVDGIENYLsvSKNRVAVLHCRMGKGRSGMITVAYLMKYLQCPLGEARLIFMQARFKYG
 |.|.|| ||. |  ....  . || .|  ||  | .|||||. ...| .|  .  ... .  
hldeavdFieeal..eeegavlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkpeie
subfamily_Auxilin_pd Subfamily Auxilin 42-102 2.8e-08 26.6 In-house 9-67 (166) alignment 
Range on Protein: 42-102
Range on HMM: 9-67/166.0
LDISYILVNLIVCSYPVNTYpKLLYRNSLDDLILFLTVYHgKGNFRIFNFRGEKEDSDYKD
||||||   .|| |.|..   .  |.|..||. .||   | .... ..|. .......  .
lDisyitsriivmsfPaegv.estyknniddvrsfLesrh.pekylvynlsqrtyrtakls
0050432 (Phosphotyrosine protein) phosphatases II 157-228 3e-08 28.8 In-house 205-279 (308) alignment 
Range on Protein: 157-228
Range on HMM: 205-279/308.0
IGWLDHFPPP-FELLEEIVDGIENYLsvsKNRVAVLHCRMGKGRSGMITVAYLM-----KYLQCPLGEARLIFMQARF
..| ||  || .| | .... ....|   .. . | ||. | ||.| . ...|.     |   . . ||   . . | 
tnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRp
subfamily_DSP14_pd Subfamily DSP14 170-226 8.7e-08 26.3 In-house 69-123 (157) alignment 
Range on Protein: 170-226
Range on HMM: 69-123/157.0
LEEIVDGIENYlsVSKNRVAVLHCRMGKGRSGMITVAYLMKYLQCPLGEARLIFMQA
..|..| ||.     |.  ...|| .|  ||  ...|||||| .  | ||  .  .|
fdevadkieev..kkkggktlvhCvaGvSRSAslclaylmkyeklsLreayklvksa
subfamily_PTPDC1_pd Subfamily PTPDC1 149-253 2.8e-07 25.2 In-house 80-176 (182) alignment 
Range on Protein: 149-253
Range on HMM: 80-176/182.0
TNNVICERIGWLDHFPPPFELLEEIVDGIENylSVSKNRVAVlHCRMGKGRSGMITVAYLMKYLQCPLGEArLIFMQARfkygMTNGVTIPSQLRYLRYH
 ....   .|| |.  .. | . .||  ..   ......||| ||  |.|| |..  .||.   .    .| . .....     .. .   .|.. .. .
eqgiyvynfgwkDygvasleriLdivkvvaf..alqegkvav.hChaGlGrtGvliacylvyakrltaeka.iklvrsk....rpksiqtreqvelvkef

EFFIT
. |..
alfli
subfamily_RNGTT_pd Subfamily RNGTT 167-228 3.7e-07 24.0 In-house 94-155 (189) alignment 
Range on Protein: 167-228
Range on HMM: 94-155/189.0
FELLEEIVDGIENYLSVSKNRVAVLHCRMGKGRSGMITVAYLMKYLQCPLGEARLIFMQARF
 |  .|.   .|.. . . ..|  .||  |  |.| . |.||..  .. . .|  .| .|| 
aeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRp
subfamily_DSP1_pd Subfamily DSP1 170-227 4.3e-07 24.2 In-house 81-136 (163) alignment 
Range on Protein: 170-227
Range on HMM: 81-136/163.0
LEEIVDGIENYLSvSKNRVAVlHCRMGKGRSGMITVAYLMKYLQCPLGEARLIFMQAR
.||... |..  . .. .| . ||..|  ||  . .|||||  .. | ||     | |
feeviefidevkk.knGkvli.hCqaGisRsstlclaylmktkrvsleeafdfvkqrR
subfamily_DSP23_pd Subfamily DSP23 147-219 8.8e-07 23.7 In-house 47-117 (148) alignment 
Range on Protein: 147-219
Range on HMM: 47-117/148.0
EETNNVICERIGWLDHFPPPFELLEEIVDGIENylSVSKNRVAVLHCRMGKGRSGMITVAYLMKYLQCPLGEA
| | |.   |..  |. ||  | ..|.|  .|.  . .||    .|| .|.||.| .   ||.|  .   .||
eatpnltlvrlriddyhppaleqvvefvrvvee..aeekneavsvhcllgrgrtgtmlacylvkerklaaaea
subfamily_DSP8_pd Subfamily DSP8 182-219 1.4e-06 21.9 In-house 89-126 (159) alignment 
Range on Protein: 182-219
Range on HMM: 89-126/159.0
SVSKNRVAVLHCRMGKGRSGMITVAYLMKYLQCPLGEA
 .|.|   ..|.  |. ||  . .||.||.|.  | ||
aksengrvlvhvlaGisrsatvaiayimktlemsldea
subfamily_DSP6_pd Subfamily DSP6 183-219 1.4e-06 21.9 In-house 90-126 (158) alignment 
Range on Protein: 183-219
Range on HMM: 90-126/158.0
VSKNRVAVLHCRMGKGRSGMITVAYLMKYLQCPLGEA
 ||.   ..||  |  ||  .|.|||||.|.. | .|
rskkskvlvhClaGisrsvtvtlaylmkklalslnda
subfamily_DSP10_pd Subfamily DSP10 184-220 1.8e-06 21.9 In-house 90-126 (159) alignment 
Range on Protein: 184-220
Range on HMM: 90-126/159.0
SKNRVAVLHCRMGKGRSGMITVAYLMKYLQCPLGEAR
.|..  ..||. |  ||  ...|||||.|.  | .| 
kkgsrvLvhCqaGisrsatvviaYlmkhlnlslnday
subfamily_DSP19_pd Subfamily DSP19 169-219 3.8e-06 21.3 In-house 74-122 (152) alignment 
Range on Protein: 169-219
Range on HMM: 74-122/152.0
LLEEIVDGIENYLSVSkNRVAVlHCRMGKGRSGMITVAYLMKYLQCPLGEA
 |.|..| ||. .|   ..| | ||. |  ||  . .|||||  .  | ||
ylkealdFieearskd.gavlv.HCnAGvSRsasvviaylmkkeelsleea
subfamily_DSP3_pd Subfamily DSP3 172-219 4.3e-06 20.5 In-house 84-130 (162) alignment 
Range on Protein: 172-219
Range on HMM: 84-130/162.0
EIVDGIENYLSVSKNRVAVlHCRMGKGRSGMITVAYLMKYLQCPLGEA
. .. |.. || .. .| | ||..|  ||  . .|||| . .  | ||
taakfidealsqkegkvlv.hcvvGvsRsatlvlayLmirrkmtlvea
subfamily_MKPLT_pd Subfamily MKPLT 189-220 6e-06 19.9 In-house 102-133 (164) alignment 
Range on Protein: 189-220
Range on HMM: 102-133/164.0
AVLHCRMGKGRSGMITVAYLMKYLQCPLGEAR
 ..|| .|| ||  .|||.|.|. .  |.|| 
vlvhcvqGksrsssvtvafLikskgwtlkeay
subfamily_MKPLV_pd Subfamily MKPLV 189-220 6e-06 19.9 In-house 102-133 (164) alignment 
Range on Protein: 189-220
Range on HMM: 102-133/164.0
AVLHCRMGKGRSGMITVAYLMKYLQCPLGEAR
 ..|| .|| ||  .|||.|.|. .  |.|| 
vlvhcvqGksrsssvtvafLikskgwtlkeay
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 171-230 7e-06 19.5 In-house 76-135 (154) alignment 
Range on Protein: 171-230
Range on HMM: 76-135/154.0
EEIVDGIENYL-SVSKNRVaVLHCRMGKGRSGMITVAYLMKYLQCPLGEARLIFMQARFKY
.   . |.. . .| .|.| ..|.  |  ||  . ..|||. |. .| .|  .  ..|.. 
dkafefiddaiggvennkv.lvhsdkGvsrsaallisylmdklkislslalellkdsryii