Gene PTP2 in Saccharomyces cerevisiae

Synonym: YOR208W, PTP2

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily Fungi-PTP2
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP070_AA protein Get Run
ScerP070_AA_366-739 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 359-743 1.3e-191 630.4 In-house 1-349 (349) alignment
Range on Protein: 359-743
Range on HMM: 1-349/349.0
SSLKSNIQKNQKLKLIIPKNNTSSSPSPLSSDDTimSPINDYELTEGIQSFTKNRYSNILPYEHSRVKLPHSPKPPAVSEASTTETKtdksypmcpvdak
||.||..||..||||||.|...|.|...|.|||.  |.|.|..|.||...|.||||..|||||||||||..|.|...|..|||.|..             
ssdkskvqkrsklkliitkysksksmlslesddd..seiddvilseGvelfaknrykdilPyehsrvklkkslksskvikastsesd.............

nhSCKPNDYINANYLKLTQINPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSYSNHTIKLQNTWENICNINGCVLRVF
  |.|..|||||||||||.|....||||||||||||.|||.|||.||.||...|||.|.||.|.|.||||..|||||.|.||||....|.|..|..|||.
..sgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqelsysnitvklqnsslyianvqGnslrvs

QVKKTAPQNDNISQDCDLPHNGDLTSITMAVSEPFIVYQLQYKNWLDScgvdmndiiklhkvknSLLFNPQSFITSLEkdvCKPDLIDDNNSELHLDTAN
.||.|...|||....||||...|...|..||..|....|||.|||||.                |||.||.|....||   .|.|||||....|.|||..
tvkdtdndndnnkknCdlpddddddaillavekPyellqlqvknwldl................slllnPisilqale...vkndliddlfarlyldtdq

SSPLLVHCSAGCGRTGVFVTLDFLLSILSPTTNHSNKIDVWNMTQDLIFIIVNELRKQRISMVQNLTQYIACYEALLNYFALQKQ
.|.||||||||||||||.||||.|||||.|..|.||||.......|||.|||||||||||||||||.|.||.|||||.||||.|.
lstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyfalkkd

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 360-744 4.3e-179 589.6 In-house 1-350 (350) alignment
Range on Protein: 360-744
Range on HMM: 1-350/350.0
SLKSNIQKNQKLKLIIPKNNTSSSPSPLSSDDTimSPINDYELTEGIQSFTKNRYSNILPYEHSRVKLPHSPKPPavseasttetktdksypmcpvDAKN
|.||..||..||||||.||.|..|...|.||..  ||.||..|.||...|.||||.||||||||||||..|.|..                     |||.
sdkskvqkrsklkliitknstvksrlsLesdse..spsnDvilseGvelfaknrYknilPYehsrvkLkkslkss.....................dakk

HSCKPNDYINANYLKLT----QINPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSYSNHTIKLQNTWENICNINGCVL
||...||||||||||||    .|||||||||||||||||.|||.|||.|||||||.||.||.||||.|...||...||...|.||...||||..||...|
hslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqegsydditvklaskwenimgindssl

RVFQVKKTAPQNDNISQDCDLPHNGDLTSITMAVSEPFIVYQLQYKNWLDScgvdmndiiklhkvknSLLFNPQSFITSLEkdvCKPDLIDDNNSELHLD
....|||.|..|||||.|.||..|..||.||.|.|.|..|||||.|||.|.                |||.||.|....||   .|.|||||...|.|||
ysadvkkeasdndnisddndlkdnnsltaitlaasdPyvvyqlqvknWkDl................slllnPesilqale...vkndliddlfaeshld

TANSSPLLVHCSAGCGRTGVFVTLDFLLS---ILSPTTNHSNKIDVWNMTQDLIFIIVNELRKQRISMVQNLTQYIACYEALLNYFALQKQI
.|.|||.|||||||.||||..||||.|||   ||...|..|.|.||...|.|||.|||||||||||||||||.|.|..|||||.||||.|.|
narsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfyfaLrkdi

DSPc_SM00195 353-738 1.9e-78 258.8 In-house 2-262 (263) alignment
Range on Protein: 353-738
Range on HMM: 2-262/263.0
LQRQYKSSLKSNIQKnQKLKLIIPKNNtssspsplssddtimspindyeltegiqsfTKNRYSNILPYEHSRVKLPHSPKPpavseasttetktdksypm
|.........|. .| .. . ...||.                              .||||.|||||.|.||||....|.                   
lkeefekleestspk.etteaekkknk..............................sknRyknilpydhtrVklkkeekk...................

cpvdaknhscKPNDYINANYLKLTqiNPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNL--SYSNHT-IKLQNTWENICN
          ...|||||||.|..  |.. ||||||.|||||..|||.... .|||.|..|....| . .|.| ||..   ...... |...........
..........egsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkk

iNGCVLRVFQVKKTAPqndnisqdcdlphngdltsitmavSEPFIVYQLQYKNWLDScGVD---MNDIIKLHKVKNSLLFNpqsfitslekdvckpdlid
 . ..||.....|...                        .|.. |.|.||||| |. ||.   .. .  |..||.|   .                   
.deiilrtleltkegk........................eetrkvtqyqyknWpdh.gvpdstksvlellravkksksts...................

dnnselhldtanSSPLLVHCSAGCGRTGVFVTLDFLLSILSPTTNhsnkidvwnmtqDLIFIIVNELRKQRISMVQNLTQYIACYEALLNYF
            |.|..||||||.||||.|||.|..|| |. ...            . || ||.||||||..|||.|.||...|||.|.|.
............sgpivVhCsaGvgRtgtfvtidiilskleeekk............vdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 353-738 1.9e-78 258.8 In-house 2-262 (263) alignment
Range on Protein: 353-738
Range on HMM: 2-262/263.0
LQRQYKSSLKSNIQKnQKLKLIIPKNNtssspsplssddtimspindyeltegiqsfTKNRYSNILPYEHSRVKLPHSPKPpavseasttetktdksypm
|.........|. .| .. . ...||.                              .||||.|||||.|.||||....|.                   
lkeefekleestspk.etteaekkknk..............................sknRyknilpydhtrVklkkeekk...................

cpvdaknhscKPNDYINANYLKLTqiNPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNL--SYSNHT-IKLQNTWENICN
          ...|||||||.|..  |.. ||||||.|||||..|||.... .|||.|..|....| . .|.| ||..   ...... |...........
..........egsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkk

iNGCVLRVFQVKKTAPqndnisqdcdlphngdltsitmavSEPFIVYQLQYKNWLDScGVD---MNDIIKLHKVKNSLLFNpqsfitslekdvckpdlid
 . ..||.....|...                        .|.. |.|.||||| |. ||.   .. .  |..||.|   .                   
.deiilrtleltkegk........................eetrkvtqyqyknWpdh.gvpdstksvlellravkksksts...................

dnnselhldtanSSPLLVHCSAGCGRTGVFVTLDFLLSILSPTTNhsnkidvwnmtqDLIFIIVNELRKQRISMVQNLTQYIACYEALLNYF
            |.|..||||||.||||.|||.|..|| |. ...            . || ||.||||||..|||.|.||...|||.|.|.
............sgpivVhCsaGvgRtgtfvtidiilskleeekk............vdifeivkelRkqRpgmvqtleqYlfiyeaileyi

Y_phosphatase Protein-tyrosine phosphatase 409-736 2.5e-73 241.8 Pfam-A 2-235 (235) alignment
Range on Protein: 409-736
Range on HMM: 2-235/235.0
FTKNRYSNILPYEHSRVKLphspkppavseasttetktdksypmcpvdakNHSCKPNDYINANYLKLTQiNpDFKYIATQAPLPSTMDDFWKVITLNKVK
..||||..||||...||||                               ..|..|.|||||||.|... . ..|.||||.||.||..|||.... .|||
kkknRykdilpydktrvkl...............................kgsegpsdYInAnyvkgyk.e.kkkfIatQgPlkstiedFWrmvwqekvk

VIISLNSDDELNLRKWDIYWN---NLSYSNHTIKLQNTwENICNIN-GCVLRVFQVKKTAPQNdnisqdcdlphngdltsitmavsEPFIVYQLQYKNWL
||. |.|..| . .|.. ||.   . |.....||.... |...... ...||....||.. ..                       |...|.||.|.|| 
vivmltsleekgrekcaqYwpeeeeesltygdikvelk.ekekedekeytlrklelkkkkees.......................ekrevkqlhytnWp

DSCgvdmndiikLHKVKNSLLfnpqSFITSLEKDVckpdliddnnselhldTANSSPLLVHCSAGCGRTGVFVTLDFLLSILSPtT-NhsnkIDVWNmtq
|..         . . ..|||    ..|...||.                 .|.|.|..||||||.||||.||.||.||. |.  . .    .||..   
dhg.........vpespksll....dlirkveksk................eaksgpvvVhCsaGvgRtgtfvaldilleqlea.eee....vdvlq...

dlifiIVNELRKQRISMVQNLTQYIACYEALLN
     ||.||||||..|||.|.|||..|.|.|.
.....ivkelRkqRpgmvqsleqYiflykaile

Y_phosphatase Protein-tyrosine phosphatase 409-736 2.5e-73 241.8 In-house 2-235 (235) alignment
Range on Protein: 409-736
Range on HMM: 2-235/235.0
FTKNRYSNILPYEHSRVKLphspkppavseasttetktdksypmcpvdakNHSCKPNDYINANYLKLTQiNpDFKYIATQAPLPSTMDDFWKVITLNKVK
..||||..||||...||||                               ..|..|.|||||||.|... . ..|.||||.||.||..|||.... .|||
kkknRykdilpydktrvkl...............................kgsegpsdYInAnyvkgyk.e.kkkfIatQgPlkstiedFWrmvwqekvk

VIISLNSDDELNLRKWDIYWN---NLSYSNHTIKLQNTwENICNIN-GCVLRVFQVKKTAPQNdnisqdcdlphngdltsitmavsEPFIVYQLQYKNWL
||. |.|..| . .|.. ||.   . |.....||.... |...... ...||....||.. ..                       |...|.||.|.|| 
vivmltsleekgrekcaqYwpeeeeesltygdikvelk.ekekedekeytlrklelkkkkees.......................ekrevkqlhytnWp

DSCgvdmndiikLHKVKNSLLfnpqSFITSLEKDVckpdliddnnselhldTANSSPLLVHCSAGCGRTGVFVTLDFLLSILSPtT-NhsnkIDVWNmtq
|..         . . ..|||    ..|...||.                 .|.|.|..||||||.||||.||.||.||. |.  . .    .||..   
dhg.........vpespksll....dlirkveksk................eaksgpvvVhCsaGvgRtgtfvaldilleqlea.eee....vdvlq...

dlifiIVNELRKQRISMVQNLTQYIACYEALLN
     ||.||||||..|||.|.|||..|.|.|.
.....ivkelRkqRpgmvqsleqYiflykaile

0050432 (Phosphotyrosine protein) phosphatases II 395-742 1.4e-57 190.7 In-house 55-303 (308) alignment
Range on Protein: 395-742
Range on HMM: 55-303/308.0
SPINDYELTEGIQSFTKNRYSNILPYEHSRVKLphS-PkppavseasttetktdksypmcpvdaknhsckpNDYINANYLKLTQINPDFKYIATQAPLPS
 |...|. ..  . ..||||..||||.||||||  . .                                 .|||||.| .. . . . |.||||.|||.
kplleysvallpenkdkNrykdilpydhsRVkl..deg.................................sdYInAsyvdgyssklprkfIatqgPlpn

TMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYW------NNLSYSNHTIKLQNTWEnicnINGCVLRVFQVKKTApqndnisqdcdlphngdltsitm
|..|||. .  ..|.||. |.. .| .  |.. ||      . | | . |..| .. .     .....|.......                        
tvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev....lddytvrtleltnlg.......................

aVSEPFIVYQLQYKNWLDSCGVD-MNDIIKLHKVKNSLLfnpQSfitslekdvckpdliddnnselhldtansSPLLVHCSAGCGRTGVFVTLDFLLSIL
  .| ..|....|.|| | .  . ....... .  .. |   ..                             .| .||||||.||||.|..|| ||. |
.dgesrtvthfhytnWpdhgvPpspeilldflelvrksl...pg.............................gpivVHCsaGvGRtGtfialdllleql

SPTTNHSnkidvwnmtqdlIFIIVNELRKQRISMVQNLTQYIACYEALLNYFALQK
  . . .            .| .|. ||.||  |||.. ||. .|.||| |. | .
ekeggvd............vfeavkklReqRpgmvqtpeqylflyralleylklkl

0036941 (Phosphotyrosine protein) phosphatases II 397-743 3.5e-57 189.3 In-house 28-282 (297) alignment
Range on Protein: 397-743
Range on HMM: 28-282/297.0
INDYELTEGIQSFTKNRYSNILPYEHSRVKLPHSPkppavseasttetktdksypmcpvdaknhsckpNDYINANYLklTQINPDFKYIATQAPLPSTMD
. ... ..  .  .||||..||||.|.||||....                                 .|||||.|.  .  . ..|.||||.|||.|..
lgslsvallpenleknRykdilpydhtRVklddeg.................................sdYinAsyv..dgydlkrkfIatqgPlpntve

DFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNL-----SYSNHTIKLQNTWENicNINGCVLRVFQVKKTapQNdnisqdcdlphngdltsitmavSE
|||. .  ..|.||..|....||.  |.. || .       | . |..|... .   . ....||...|..|  .|                      .|
dFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevv..llddytlrtlevtdt..gn......................ge

PFIVYQLQYKNWLDSCGVD-MNDIIKLHKVKNSLLfnPQSfitslekdvckpdliddnnselhldtANSSPLLVHCSAGCGRTGVFVTLDFLLSILS---
...|....|..| | .  . ....... .  .. |  ...                           ...| |||||||.||.|.|...| .|. |    
srtvthfhytgwpdhgvpespaslldfielvrkvl..kll..........................psggpvlVHCsaGvgRsgtfiaadlmlqqledkl

PTTNHSnkidvwnmtqdlIFIIVNELRKQRISMVQNLTQYIACYEALLNYFALQKQ
 . . .            |. .|..||.||  .||.| ||. .|||||...  ...
keggvd............ileavkklReqRpgavqtleqyrflyeallellkkklt

0051299 (Phosphotyrosine protein) phosphatases II 396-738 4.8e-56 185.7 In-house 37-286 (288) alignment
Range on Protein: 396-738
Range on HMM: 37-286/288.0
PINDYELTEGIQSFTKNRYSNILPYEHSRVKLPhspkppavseasttetktdksypmcpvdaKNHSCKPNDYINANYLKLTQINPDfkYIATQAPLPSTM
| ...  .   . ..|||||.||||.||||||                                ... ..|||||.|... ...    .||||.|||.|.
pdltlsaallpenleknRysdilpydhsRVkLs.............................vldgvegsdYinAsyidgynlkrk..fIatqgPlpntv

DDFWKVITLNKVKVIISLNSDDELNLRKWDIYWN---NLSYSNHTIKLQNTWEnicnINGCVLRVFQVKKTAPQNdnisqdcdlphngdltsitmAVSEP
.|||. .  ..|.||..|.. .||. .|.. ||.    | | . |..| .. .     .....|...|...   .                      .|.
edFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseev....lddytvrtlevtnldlld....................gdges

FIVYQLQYKNWLDSCGVD-MNDIIKLHKVKNsllfnpqsfitslekdvckpD--LiddnnselhldtANSSPLLVHCSAGCGRTGVFVTLDFLLSILSPT
..|....|.|| | .  | ....... .  .                    .               ....| .||||||.||||.|..|| ||. |  .
rtvthfhytnwpdhgvpdspellldflrlvr....................kala............sgggpvvVHCsaGvgRtgtfialdllleqleke

TNHSnkidvwnmtqdlIFIIVNELRKQRISMVQNLTQYIACYEALLNYF
   .            .. .|. ||.||  |||.. ||. .||||| |.
ggvd............vleavkrlreqRpgmvqtpeqyrfvyealleyl

0040438 (Phosphotyrosine protein) phosphatases II 396-739 5.6e-56 185.5 In-house 31-277 (317) alignment
Range on Protein: 396-739
Range on HMM: 31-277/317.0
PINDYELTEGIQSFTKNRYSNILPYEHSRVKLPHspkppavseasttetktdksypmcpvdakNHSCKPNDYINANYLKLTQINPDfkYIATQAPLPSTM
....|. .|  ..  ||||..||||.|||||| .                               .  ..|||||.| .  ....   .||||.|||.|.
kldtysvaelpenkdknrypdilpydhsRVkLsp.............................lggdldsdYInAsyvdgpnlkrk..fIatqgPlpntv

DDFWKVITLNKVKVIISLNSDDELNLRKWDIYWN---NLSYSNHTIKLQNTWEnicnINGCVLRVFQVKKTAPqndnisqdcdlphngdltsitmavSEP
.|||. .  ..|.||..|.. .||. .|.. ||.    | | . |..|... |     .|..||...|...                          ||.
edFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseee....lagitlrtlevedlgd........................ses

FIVYQLQYKNWLDSCGV-DMNDIIKLHKVKNSLLfnpqsfitslekdvckpdliddnnselhldTANSSPLLVHCSAGCGRTGVFVTLDFLLSILSPTTN
..|....|..| | .   ........ .  .. |                                ...|.|||||||.||||.|.... .|. |  . .
rtvthfhytgWpdhgvppspdllldfleavreal..............................edpggpvlVHCsaGvgRtGtfiaaylmleqlekegg

HSnkidvwnmtqdlIFIIVNELRKQRISMVQNLTQYIACYEALLNYFA
 .            .. .|.|||.||  .||.. ||. .|.|||.|. 
vd............veeavkelreqRpgavqtpeqyrflydalleylk

0045450 (Phosphotyrosine protein) phosphatases II 397-738 2.7e-54 180.3 In-house 44-304 (307) alignment
Range on Protein: 397-738
Range on HMM: 44-304/307.0
INDYELTEGIQSFTKNRYSNILPYEHSRVKLPHSPkppavseasttetktdksypmcpvdaknHSCKPNDYINANYLKL------TQINPDFKYIATQAP
...|. ..  .. .||||..||||.|.|||| . .                            .| ...|||||.| ..         . . |.||||.|
lgeysiallpenkdknrykdilpydhtRVklssld............................gsledsdYiNAsyvrvpllllldgydlkrkfIatqgP

LPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNL----SYSNHTIKLQNTWEnicnINGCVLRVFQVKKTAPQNdnisqdcdlphngdltsit
||.|..|||. .  ..|.||..|....||. .|.. || .      | | |..| .. .     .|...|.. |. . . .                   
lpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh....ldgytvrtlevtdldgtg...................

mavsEPFIVYQLQYKNWLDSCGV-DMNDIIKLHKVKNSLLFNpqsfitslekdvckpdliddnnselhldTANSSPLLVHCSAGCGRTGVFVTLDFLLSI
    |...|....|..| | .   ........ .  .. | .                            . ...| |||||||.||||.|.... .|. 
....esrtvthfhytgwpdhgvppsfeelldfieevrkalee............................lpkggpvlVHCsaGvgRtGtfiaaylmlrq

LS--------PttnhsnkidvwnmtqdlIFIIVNELRKQRISMVQNLTQYIACYEALLNYF
|         .                 .. .|..||.||  .|||. ||. .||||| ..
lekegtlldvd.................lleavkllreqRpgavqnpeqyrflyeallell

0043336 (Phosphotyrosine protein) phosphatases II 398-738 6.7e-54 178.6 In-house 35-277 (278) alignment
Range on Protein: 398-738
Range on HMM: 35-277/278.0
NDYELTEGIQSFTKNRYSNILPYEHSRVKLPHspkppavseasttetktdksypmcpvdakNHSCKPNDYINANYLKLTQINPDfkYIATQAPLPSTMDD
..|. .. .....||||..||||.|||||| .                               .. ..|||||.|... .....  .||||.|||.|..|
dtysiallpenkdknrykdilpydhsrvklsl.............................lggdldsdYinAsyvdgynvprk..fiatqgPlpetved

FWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSYSNHTIKLQNTWENIcnINGCVLRVFQVKKTAPQndnisqdcdlphngdltsitmavsEPFIVYQ
||. .  ..|..|..|....||.  |.. ||.. |.  ....  .. |.    .....|.. |...                           |...|..
FwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeeh..lddytvrtlevtnlgdg........................esrtvth

LQYKNWLDSCGV-DMNDIIKLHKVKNSLLfnpqsfitslekdvckpdliddnnselhldTANSSPLLVHCSAGCGRTGVFVTLDFLLSILSPTTNHSnki
..|..| | .   ........ |. .. |                                ...|.|||||||.||||.|..|. ||. |  . . .   
yhylgwpdhgvpeslsllldflkavreal..............................edsngpvlVHCsaGvgRTGtfialyllleqlekeggvd...

dvwnmtqdlIFIIVNELRKQRISMVQNLTQYIACYEALLNYF
         .. .|.|||.|| ..||.. ||. .||||| |.
.........leeavkelreqRpgavqtpsqyrflyealleyl

0046845 (Phosphotyrosine protein) phosphatases II 397-743 2.5e-53 176.6 In-house 17-279 (284) alignment
Range on Protein: 397-743
Range on HMM: 17-279/284.0
INDYELTEGIQSFTKNRYSNILPYEHSRVKLPHSPkppavseasttetktdksypmcpvdaknHSCKPNDYINANYLKLTQI---NPDFKYIATQAPLPS
. ... .   . ..||||..||||.|||||| . .                            .... .|||||.|..  ..   .   |.||||.|||.
llslsvallpenlsknRykdilpydhsRVklksld............................gdledsdYinAsyvdgydldltyikkkfIatqgPlpn

TMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLS----YSNHTIKLQNTWEnicnINGCVLRVFQVKKTAPqndnisqdcdlphngdltsitmaV
|..|||...  ..|.||..|.. .| .  |.. ||.. .    | . |..| ....     .....|....... .                        
tvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseev....kddytvrtleltnlgy.......................t

SEPFIVYQLQYKNWLDSCGV-DMNDIIKLHKVKNSLLFNpqsfitslekdvckpdliddnnselhldTANSSPLLVHCSAGCGRTGVFVTLDFLLSILSP
.|...|....|..| | .   ...|.... .  ..|| |                            . ...| .||||||.||||.|..|| ||. |  
gesrtvthfhytswpdhgvppspedlleflrlvrellen............................lpgggpivVHCsaGvgRtGtfialdllleqlek

TT---NHSnkidvwnmtqdlIFIIVNELRKQRISMVQNLTQYIACYEALLNYFALQKQ
.    . .            .. .|. ||.||  |||.| ||. .|||||.|. | ..
eglllgvd............vleavkrlreqRpgmvqtleqyrfvyealleylklklt

0039614 (Phosphotyrosine protein) phosphatases II 391-739 3.8e-53 176.2 In-house 39-290 (297) alignment
Range on Protein: 391-739
Range on HMM: 39-290/297.0
DTIMSPINDYELTEGIQSFTKNRYSNILPYEHSRVKLPHSPkppavseasttetktdksypmcpvdaknHSCKPNDYINANYLKLTQINPDfKYIATQAP
 ...| . ||. .. ... .||||..||||.|||||| . .                            ..  ..|||||.|..   .... |.||||.|
eellslkpdysiallpenkdknrykdilpydhsrvklkped............................gvdldsdYinAsyvdgydlltr.kfIatqgP

LPSTMDDFWKVITLNKVKVIISLNSDDELNLrKWDIYWNNLSYSNHTIKLQNTWENIcnINGCVLRVFQVKKtapqNDnisqdcdlphngdltsitmavs
||.|..|||. .  ..|.||..|.. .||.  |.. || . .   ....  .. .     .|...|.. |..    |.                      
lpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeeggtygdftvtllkveh..ldgytvrtlevtn....ng......................

EPFIVYQLQYKNWLDSCGV-DMNDIIKLHKVKNSLLFNpqsfitslekdvckpdliddnnselhldTANSSPLLVHCSAGCGRTGVFVTLDFLLSILSPT
|...|...|| .| | .   ........ .  .. | .                            . .. | |||||||.||||.|.... .|. |  .
esrtvthfqytgwpdhgvppslellleflelvrealae............................lpkggpvlVHCsaGvgRtGtfiaaylmleqleke

TNHSnkidvwnmtqdlIFIIVNELRKQRISMVQNLTQYIACYEALLNYFA
 . .            .. .|.|||.||  .||.. ||. .|.||| .. 
ggvd............vleavkelreqRpgavqtpsqyrflydallellk

0047943 (Phosphotyrosine protein) phosphatases II 396-738 1.9e-51 170.5 In-house 26-272 (273) alignment
Range on Protein: 396-738
Range on HMM: 26-272/273.0
PINDYELTEGIQSFTKNRYSNILPYEHSRVKLphspkppavseaS----TtetktdksypmcpvdaknhsckpndYINANYLKLTQINPDfkYIATQAPL
|. .|. .. .. ..||||..||||.||||||            .                              ||||.|... ....   .||||.||
plltysvallpenkdknrykdilpydhsrvkl............gdggsd.........................yinAsyvdgynlkrk..fiatqgPl

PSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWN------NLSYSNHTIKLQNTWEnicnINGCVLRVFQVKKTApqndnisqdcdlphngdltsi
|.|..|||. .  ..|.||..|....||. .|.. ||        | | . |..| .. .     .....|.......                      
pntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet....kddytvrtleltnlg.....................

tmaVSEPFIVYQLQYKNWLDSCGV-DMNDIIKLHKVKNSLLFnpqsfitslekdvckpdliddnnselhlDTANSSPLLVHCSAGCGRTGVFVTLDFLLS
    .|...|....|..| | .   ........ .. .. |                              . ...| .||||||.||||.|..|| ||.
...tgesrtvthfhytgwpdhgvppslesllefielvrkale............................alpsngpvvVHCsaGvgRtgtfialdllld

ILSPTTNHSnkidvwnmtqdlIFIIVNELRKQRISMVQNLTQYIACYEALLNYF
 |  . . .            .. .|. ||.||  |||.. ||. .|||||.|.
qlekeggvd............vleavkllrsqRpgmvqtpeqyrflyealleyl

0045098 (Phosphotyrosine protein) phosphatases II 392-738 8.9e-50 165.0 In-house 17-272 (278) alignment
Range on Protein: 392-738
Range on HMM: 17-272/278.0
TIMSPINDYELTEGIQSFTKNRYSNILPYEHSRVKlphspkppavseasttetktdksypmcpvdaknhsckpnDYINANYLKLTqinpDFKYIATQAPL
 .........    . .. ||||..||||.|||||                                       |||||.|..      ..|.||||.||
lllgipseitpalylgnldknRykdilpydhsrVk.......................................dYINAsyidgy....pkkfIatqgPl

PSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNN---LSYSNHTIKLQNTWENicniNGCVLRVFQVKKTA----Pqndnisqdcdlphngdlts
|||..|||. .  ....||..|..  ||.  |.. || .   | | . |..|... ..    .  .||.. |  .                         
pstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevl....ddytlrtllvtnltvered...................

itmavSEPFIVYQLQYKNWLDSCGVDMN---DIIKLHKVKNSLLFNPQSFITSLEkdvckpdliddnnselhLDTANSSPLLVHCSAGCGRTGVFVTLDF
      |.. |..|.|..| | .  ...    ...| .  .. | . .|...|                   |   .. | |||||||.||||..| .. 
.....lesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssl.................llldsggpvlVHCsaGvgRtGtlvaayl

LLSILspttnH---SnkidvwnmtqdlIFIIVNELRKQRIS-MVQNLTQYIACYEALLNYF
.|. |     .   .            .. .|.|||.||   .|||| ||. .||.|| ..
mlell.....eggvd............lleavkelrsqRpglavqnleqyrflyefllell

0040439 (Phosphotyrosine protein) phosphatases II 399-738 1.9e-49 163.9 In-house 2-246 (249) alignment
Range on Protein: 399-738
Range on HMM: 2-246/249.0
DYELTEGIQSFTKNRYSNILPYEHSRVKLPHspkppavseasttetktdksypmcpvdakNHSCKPNDYINANYLKLTQINPDfkYIATQAPLPSTMDDF
.|. ..   .  ||||..||||.|||||| .                               .. ..|||||.|.....|...  .||||.|||.|..||
eysvallpenkdknrypdilpydhsrvklsi.............................lpglflsdyinAsyidgyyikrr..fiatqgPlpetvedf

WKVITLNKVKVIISLNSDDELNLRKWDIYWNN---LSYSNHTIKLQNTWEnicnINGCVLRVFQVKKTApqndnisqdcdlphngdltsitmaVSEPFIV
|. .  ....||..|.|..||.  |.. ||..   | | . |..| .. .     .....|.......                          .|.. |
wrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvev....kddytvrtleltnly........................dgesrtv

YQLQYKNWLDSCGV-DMNDIIKLHKVKNsllfnpqsfitslekdvckpdliddnnseL----HldtANSSPLLVHCSAGCGRTGVFVTLDFLLSILSPTT
...|| .| |     ...|.... .  .                                       ...|.|||||||.||||.|.... .|. |  . 
lhiqytdwpdhgvppsfedlldfieavr.............................kaleel...pkggpvlVHCsaGvgRtGtfiaaylmleqlekel

NHSnkidvwnmtqdlIFIIVNELRKQRISMVQNLTQYIACYEALLNYF
. .            .. .|..||.||  .|||. ||. .||||| ..
gvd............leeavkllrsqRpgavqnpeqyrflyeallell

0042113 (Phosphotyrosine protein) phosphatases II 403-738 5.9e-49 162.0 In-house 4-243 (245) alignment
Range on Protein: 403-738
Range on HMM: 4-243/245.0
TEGIQSFTKNRYSNILPYEHSRVKLPHSPKPPAVSeasttetktdksypmcpvdaknhsckpndYINANYLKLTQINPDfkYIATQAPLPSTMDDFWKVI
.. . . .|||||.||||.|.||||.. .  . ..                             ||||.| .. .|.|   .||||.|||.| .|||. .
allpenkdknrysdilpydhtrvklspdggdldsd.............................yinasyvdgyritpk..fiatqgPlpetvedfwrml

TLNKVKVIISLNSDDELNLRKWDIYWNNlSYSNHTIKLQNTWENICNINGCVLRVFQVKKTAPqndnisqdcdlphngdltsitmavSEPFIVYQLQYKN
  .....|..|....||.  |.. ||.. . |  . ... |. .. . .....|...|...                          .|.. |....| .
welgittivmLteeeelgrvkcaqywpl.gesltygdftvtllseehlddytvrtlevtnlgd........................desrevihyhylp

WLDSCGVD-MNDIIKLHKVKNsllfnpqsfitslekdvckpdliddnnS---ElhldtANSSPLLVHCSAGCGRTGVFVTLDFLLSILSPTTNHSnkidv
| | .  | .........  .                           .   |      .. |.|||||||.||||.|.... .|. |  . . |     
wpdhgvpdllellldflefvr...........................kalae.....dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvs.....

wnmtqdlIFIIVNELRKQRISMVQNLTQYIACYEALLNYF
       .. .| |||.||  .||.. ||. .|||||...
.......leeavkelrsqRpgavqtpsqyrflyeallell

0037934 (Phosphotyrosine protein) phosphatases II 406-738 5.4e-48 159.0 In-house 8-242 (243) alignment
Range on Protein: 406-738
Range on HMM: 8-242/243.0
IQSFTKNRYSNILPYEHSRVKLphspkppavseasttetktdksypmcpvdaknhscKPNDYINANYLKLTqinPdfKYIATQAPLPSTMDD----FWKV
... .|||||.||||.||||||                                   ...||||||. . |   |  ..||||.|||.| .|    ||. 
penlsknrysdilpydhsrvkl...................................egsdyinanliyvt...p..rliatqgPlpetveddlasfwrm

ITLNKVKVIISLNSDDELNLRKWDIYWNnLSYSNHTIKLQNTWENICniNGCVLRVFQVKktapqndnisqdcdlphngdltsitM--AVSEPFIVYQLQ
.  ....||..|....||.  |.. ||.  ..  .... ... |. .  .....|.....                         .  .  ... |....
lwelgitvivmltelvElgrekcaqywp.gevtygdftvtllseehl..ddytvrtllle.........................nldlddltrlvihyh

YKNWLDSCGVD-MNDIIKLHKVKNSLLFNPQSFItslekdvckpdliddnnselhlDTANSSPLLVHCSAGCGRTGVFVTLDFLLSILspttnH-Snkid
| .| | .  | ..|......  .. . .  |..                         ...|.|||||||.||||...... .|. |     . .    
ylpwpdhgvPdspedlldfldevrefieellsll......................aldsggpvlVHCsaGvgRtGtliaaylmllll.....gvd....

vwnmtqdlIFIIVNELRKQRIS-MVQNLTQYIACYEALLNYF
        .. .|..||.||   .||.. ||. .||||| ..
........leeavkllreqRpgkavqtpsqyrflyeallell

subfamily_PTPRD_pd Subfamily PTPRD 464-741 1.4e-39 131.2 In-house 75-284 (564) alignment
Range on Protein: 464-741
Range on HMM: 75-284/564.0
PNDYINANYLKLTQinPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSySNHTIKLQNTWENICNINGCVLRVFQVKKT
  |||||....  .   . .|||||.||..|..|||. .. .....|. |..  | .  | . || . . . .  .|. | |.  ...  ..| |..||.
gsDYINAsfidgyr..krkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfklkkk

ApqndnisqdcdlphngdltsitmaVSEPFIVYQLQYKNWLDSCGVDM-NDIIKL-HKVKNSLLfnpqsfitslekdvckpdliddnnselhldtANSSP
                          ||   | | .. .| |..  .  .....| .||...                                  .. |
k........................ssesreVrqFhFtsWPdhgvpesatslLdlirkvralne...............................pdagP

LLVHCSAGCGRTGVFVTLDFLLSILspttNHSNKIDVWNMtqdlifiiVNELRKQRISMVQNLTQYIACYEALLNYFALQ
..|||||| ||||.|...| .|  .    ......|....        |..|||||  |||. .||| ..||.|.. | .
ivVhCSaGVGRTGtfividamleri....keektvDiyqy........vkalrkqRnamVqteeQYiFiheailealacg

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 406-738 3.2e-37 123.1 In-house 26-268 (274) alignment
Range on Protein: 406-738
Range on HMM: 26-268/274.0
IQSFTKNRYSNILPYEHSRVKL-PHSPKppavseasttetktdksypmcpvdaknhsCKPNDYINANYLKLTQINPDfKYIATQAPLPSTMDDFWKVITL
  | ||||| .||| |.||| | ..|..                              .  .||||||.|  . .    |.||| |||.|..|||..|  
fgsqtknryktilPnensrvllesesse.............................dedssyinanyikGydeesk.ayvatqGPlpntvadfWrmiyq

NKVKVIISLNSDDELNLRKWDIYWNNLS-Y--SNHTIKLQNTWENICNINGCVLRVFQVKKTAPQNDnisqdcdlphngdltsitmavsepfiVYQLQYK
..|.||. |    | | .|   |. .   |  |.. .... . |.| . |.  .| . .|..  ...                          |.   | 
eevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerers..........................vkhywyt

NWLDSCGVD-MNDIIKLHK-VknsllfnpqsfitslekdvckpdliddnNSELHLDTANSSPLLVHCSAGCGRTGVFVTLDFLLSILSPttnhsnkidvw
.| |    | .| ...| . |                            ... . ..|. .| .|||||| ||||.|.. .  .  |             
dWPdhksPddantlldlvlev............................eesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlre...........

NMTQDlIFIIVNELRKQRISMVQNLTQYIACYEALLNYF
... | .. || .|| .|  |||.  ||   ..||  | 
eivvd.vlkivcnlrldrGGmvqtseqyelihralclyl

0041856 (Phosphotyrosine protein) phosphatases II 408-741 9.1e-32 105.5 In-house 1-174 (182) alignment
Range on Protein: 408-741
Range on HMM: 1-174/182.0
SFTKNRYSNILPYEHSRvklphspkppavseasttetktdksypmcpvdaknhsckPNDYINANYLKLTQINPDfkYIATQAPLPSTMDDFWKVITLNKV
...|||||.||||.|||                                       ..||||||..   . . .  .||||.||.||. ||.. .  ...
nldknrysdilpydhsr.......................................dldyInanlylgslpatr..fiatqgpllstvadflrmlkelgi

KVIISLNsddelnlrkWDIYWNNLSysnhtiklqntwenicningcvlrvfqvkktapqndnisqdcdlphngdltsitmavsePFIVYQLQYKNWLDSC
..|..|.          . || .|                                                            .  ..|..| .| | .
ttivnlt.........eelywpell...........................................................erlgiqylylpwpDhg

GVDMNDIIKLHKVKNSllfnpqsfitslekdvckpdliddnnselhldtaNSSPLLVHCSAGCGRTGVFVTLDFLLSIlspttnhsnKIDvwnmtqdlIF
  |....... .  ..                                  .. | |||||||.||||..| ......          ...        ..
vpdldelldfieevle..................................eggpvlVHCsaGvgRtgtlvaaylmkkl.........gvs........le

IIVNELRKQRISMVQNLTQYIACYEALLNYFALQ
 .|...|..|  ||... ||. .. ||| .. |.
eavklvrsrRpgmvitpnqyfflqlallellllk

0051429 (Phosphotyrosine protein) phosphatases II 465-739 1e-29 99.5 In-house 4-226 (272) alignment
Range on Protein: 465-739
Range on HMM: 4-226/272.0
NDYINANYLKLTqinpdFK------YIATQAPLPSTMDDFWKViTLNKVKVIISLNSDDELNLRKWDIYWN-----------NLSYSNHTIKLQNTWENI
..||||....       ..      ......||| | .|||.    ...|.|..| |..|..  |.| ||            .  ..   ..|  |.  .
sgyiNardvggy.....grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllse

CNINGCVLRVFQVKKTAPqndnisqdcdlphngdltsitmaVSEPFIVYQLQYKNWLDSCGVD--MNDIIKLHkvknsllfnpqsfitslekdvckpdli
 . . ..||....... .                        .|.. |..|.| .|.| .  .  . ....|                            
ellldyilrellltllls.......................agearevmhlhytdwpdhgvpqeallellell...........................

ddnnselhLDtanSSPLLVHCSAGCGRTGVFVTLDFLLsilsPTTNHSNKIDVWNMTQDLIFIIVNELRKQRISMVQNLTQYIACYEALLNYFA
        ||   . |.|||||||..|||..| |. ||       ...  .| . .|   .. .|.|||.||  .||. .||. .|||||... 
........ld...ggpvlvHCsaGkdRTGtvvalllll....lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellr

0036282 (Phosphotyrosine protein) phosphatases II 465-732 1.6e-29 98.2 In-house 2-164 (174) alignment
Range on Protein: 465-732
Range on HMM: 2-164/174.0
NDYINANYLKLTQINPdfKYIATQAPLPstmddFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNlsysnhtiklqntwenicningcvlrvfqvkkta
.|||||..|.|. |.|  ..||.|.||.     ||. .  ........|..  ||.| |.  ||.                                   
sdyinaspldlsyitp..rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..................................

pqndnisqdcdlphngdltsitMAVSEPFIVYQLQYKNWLDSCGVDMNDIIKLHKVKNSLLfnpqsfitslekdvckpdliddnnselhldtA--NSSPL
                      .  ..   ..|..| .| | .  |.. .... |  .. |                               .  .. |.
......................lredlerlgiqylylpwpDhgvpdlsillefvkfveeal...............................sedpggpv

LVHCSAGCGRTGVFVTLDFLLSILSPTTNHSnkidvwnmtqdliFIIVNELRKQRISMVQNLTQYIACYE
|||||||.||||..| .. .|  | ... .              . .| |||.||  |||.  ||. .|.
lVHCsaGvgRtGtlvaaylmlrglleslvda.............ldlvrelRlqrpgmvqtpsQyrflyy

subfamily_Ptp69D_pd Subfamily Ptp69D 464-739 5.2e-29 96.3 In-house 75-287 (307) alignment
Range on Protein: 464-739
Range on HMM: 75-287/307.0
PNDYINANYLKltQINPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWN-NLSYSNHTIKLQNTWENICniNGCVLRVFQVKK
  |||||...|    .  .|.|| |.|. .|..|||..|.  .|..|. |   .| | .| . ||  .       |  .   |. .  .  . | ..| |
dsdYinasfik..gykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekh..sdyiiReldvsk

TAPQNDNIsqdcdlphngdltsitmavSEPFIVYQLQYKNWLDSCGVD-MNDIIKLHKVK-NSLLFNpqsfitslekdvckpdliddnnselhldtanSS
.  .  ..                    .   | | .|..| ||   .  . ..|| .   .   .|                                |
kkeesgev...................edsrkvvqyhytgWkDskvPevargllklieqvrelykln...............................rs

PLLVHCSAGCGRTGVFVTLDFLLSilspTTNHSNKIDVWNMtqdlifiiVNELRKQRISMVQNLTQYIACYEALLNYFA
|..|||||| ||.|.||.|| ||      ..  .|.|....        | .||.||  .||.| ||. .| |||.|  
PivvhCsaGvgrsgifvaldsllq....qlkaedkvdifet........vkdLrsqRnllvqsleqYvflyralldyss

0049772 (Phosphotyrosine protein) phosphatases II 409-741 7.2e-27 90.3 In-house 47-283 (314) alignment
Range on Protein: 409-741
Range on HMM: 47-283/314.0
FTKNRYSNILPYEhSRVKLPHSPKppavseasttetktdksypmcpvdaknhscKPNDYINANYLKLTqinpdFKYIATQAPLPSTMDDF----------
 .|||| .|||.. .||.||  |                               .  |||||.|..        |.||||.||. |..||          
rdknryldilpad.nrvilpglpv..............................sgsdyinasyvdgf.....lkfIatqgpleitvvdfreepvlyyng

WKVI--TLNKVKVIIS---------------------LNSDDELNlrkwdiywnnlsysnhtiklqntwenI----------Cningcvlrvfqvkktap
|...    ..| .|                       |.. |...                                     .                 
wrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng..........................neptaadlellk.................

qndnisqdcdlphngdlT-------SitmavsePFIVYQLQYKNWLDSCGVDMNDIIKLHKVKNSLlfNpqsfitslekdvckpdliddnnselhldtaN
                 .               .  .... . .. | .  . .|. .. .. ...  .                              .
.................eelydpelf.......erlgikylripvpDgsaplledfdeflefieea..d..............................k

SSPLLVHCSAGCGRTGVFVTLDFLLSILSpttnhsnkidvwnMTQDLIfiiVNELRKQRI-----SMVQNLTQYIACYEALLNYFALQ
 .|.||||.||.||||.||....|.. |              .. . .   ....|..|      .....| ||. ..||||.|.  .
ggpvlvHCkaGkgRtgtfvvaaylmkllg.............vsleea...ledvrlkRpinpnpgfieqleqyefilealleylkfl

subfamily_PTPN14_pd Subfamily PTPN14 461-738 1.7e-26 87.9 In-house 72-296 (300) alignment
Range on Protein: 461-738
Range on HMM: 72-296/300.0
SCKPNDYINANYLKLTQINPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSYSNHTIKLQNtwenicningcvlrvFQV
  . ..||||  .| .    . .||..|.||. |. |||...  ..|..|. | .. |    |   |. .|. ...|.. ..               |.|
kenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgk...............fkv

KKtapqndNISQDCDLPHNGDLTSITMAVSEPFIVYQLQYKNWLDS-CGVDMNDIIklhkvknsllfnpqsfiTSLEKdVckPDLIDDNNSELHLdTANS
 .      . |.| |      |.   .  .|   |. |||..| |  .  |... .                   ||. |    .    ||| .  . ..
tt......kfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgfl.................syLee.v..qsvrrktnseves.kesk

SPLLVHCSAGCGRTGVFVTLDFLLSilspTTNHSNKIDVWNMtqdlifiiVNELRKQRISMVQNLTQYIACYEALLNYF
 |.||||||| ||||| .. |.|..    | .| ..||. ..        .. ||.|| ..||.|.||   |..|..|.
PPvlvhCsaGvGrtGvlilsdllia....tlehneeidikkv........larLreqrmllvqtlaqYkfvYkvlikyl

subfamily_PTPRG_pd Subfamily PTPRG 465-739 5.2e-26 86.0 In-house 76-288 (563) alignment
Range on Protein: 465-739
Range on HMM: 76-288/563.0
NDYINANYLKltQINPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNN---LSYSNHTIKLQNTWENICningCVLRVFQVK
 |||||||..    .   ..|||| ||..|.||||..|  ..|..|. .    | . || |.|| .   . | . ...|...   ..       | ...|
lDYinAnyid..GyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlal....ytvrtlvik

KTAPQNDNIsqdcdlphngdltsitmaVSEPFIVYQLQYKNWLDsCGVDMNDIIKLHKVKNSllfnpqsfitslekdvckpdliddnnseLHLDTANSSP
..  .. .                     .   |.| .| .| | .||    . .|  || |                                 |.  |
nlklkkkkq..................cdteklvrqyhytkWPd.hgvPehslpvLifvkks............................saankaeaGP

LLVHCSAGCGRTGVFVTLDFLLSILspttNHSNKIDVWNmtqdlifiIVNELRKQRISMVQNLTQYIACYEALLNYFA
..|||||| ||||... || ||  .    .. |...|..        ..  .| ||  .||.  |||  ..|||.  |
ivvHcsaGvgrtGtyivldtllkqi....qqenavnvfg........flkhiraqRnflvqteEqYiflhdalleaia

0043147 (Phosphotyrosine protein) phosphatases II 464-732 3.6e-25 84.1 In-house 4-155 (172) alignment
Range on Protein: 464-732
Range on HMM: 4-155/172.0
PNDYINANYLKLTQINPDfkYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDdelnlrkwdiywnnlsysnhtiklqntwenicningcvlrvfqvkkt
..|||||.||.|. | ..  .||||.||..|..|||. .  .....|..|..                                                
gsdyinasyldlyyipdr..fiatqgplrntladfwrmlkelgithivnltel...............................................

apqndnisqdcdlphngdltsITMAVSEPFIVYQLQYKNWLDSCGVDMNDIIKLHKVKNSLLF--NpqsfitslekdvckpdliddnnselhldtanSSP
                      . .  .   ..|..| .| | .  ... .... .  ..||   .                               . |
.....................lydpellerlgiqylylpwpDhgvpllellleflefidellalsp...............................ggp

LLVHCSAGCGRTGVFVTLDFLLsilspttnhsNKIdvwnmtqdLIFIIVNELRKQRISMVQNLTQYIACYE
 |||||||.||||..| .. .|           ..         .. .|...|..|  .|||  ||. .|.
vlVHCsaGvgRtgtlvaaylml..........lgl........sleeavalvrekRpgavqnpsqyrflyy

PTPc_DSPc_SM00012 595-735 3.9e-24 80.2 In-house 2-104 (105) alignment
Range on Protein: 595-735
Range on HMM: 2-104/105.0
VYQLQYKNWLDSCGVD-MNDIIKL-HKVKNSLLFNPQsfitslekdvckpdliddnnselhldtanSSPLLVHCSAGCGRTGVFVTLDFLLSILSPTTnh
|....|..| | .  . ...|..| ..||..   . .                             |.|..||||||.||||.||.|| ||. |. .|  
vkhyhytgwpdhgvPeesdsilellravkknknkses.............................skpvvVhCsaGvgRtgtfvaldillqqleket..

snkidvwnmTQDLIFIIVNELRKQRISMVQNLTQYIACYEALL
         ... || ||.|||||| .|||...||. .|.|||
.........kevdifqivkelrkqRpgmvqteeqylflyrall

0046846 (Phosphotyrosine protein) phosphatases II 464-737 2.8e-22 74.8 In-house 11-172 (176) alignment
Range on Protein: 464-737
Range on HMM: 11-172/176.0
PNDYINANYLKLTqinpdfKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNlsYSNHTIklqntwenicningcvlrvfqvkkt
. ||||||..         ..||||.|||.|. ||.. .  ........|... ||.  |.. ||.   . .. |                         
dldyinanlilgs......rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi.........................

apqndnisqdcdlphngdltsitmavsepfivyQLQYKNWLDSCGVDMNDIIKLHKVKNSLLfnpqsfitslekdvckpdliddnnselhldtANSSPLL
                                 | .. .| | .  |......| .  .. |                                .  | |
.................................qylhlpwpDhgvpdlelllellefireal...............................keggpvl

VHCSAGCGRTGVFVTLDFLLSilspttnhSNKIDVwnmtqdliFIIVNELRKQRI-SMVQNLTQYIACYEALLNY
||||||.||||..| .. | .        .. ..|        . .. ..|.||   .||.  ||  .||..| .
VHCsaGigRtgtlvaayllel........ekglsv........eealalvreqRplgavqtpeQyrflyefelll

0049260 (Phosphotyrosine protein) phosphatases II 479-732 9.7e-22 72.7 In-house 6-144 (152) alignment
Range on Protein: 479-732
Range on HMM: 6-144/152.0
NPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWnnlsysnhtiklqntwenicningcvlrvfqvkktapqndnisqdcdlph
.. |..||||.|.| |..|||. .  .....|..|....||.  |.. |.                                                  
ampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..................................................

ngdltsitmavsepfivyQLQYKNWLDSCGVDMNDIIKLHKVKNSL-LFNPQSfitslekdvckpdliddnnselhldtanssPLLVHCSAGCGRTGVFV
                  | .. .| |..  |. ....         . ...                               | |||||||.||||..|
..................qylhlpwpDhgvpdlsqlllflllfieklaldkgg..............................pvlVHCsaGvgRtgtlv

TLDFLLsilspttnhsnkidvwnmTQDLIFIIVNELRKQRISMVQNLTQYIACYE
 .. .|                   .  .. .|. .|..|  .|.|  |.. .||
aaylml..................lgvsleeavalvrekRpgavpnpgqlrflye

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 411-736 2.8e-21 70.6 In-house 36-264 (283) alignment
Range on Protein: 411-736
Range on HMM: 36-264/283.0
KNRYSNILPYEHSRVKLPHSPKppavseasttetktdksypmcpvdaknhsckpnDYINANYLKLTQ-INPDFKYIATQAPLPSTMDDFWKVITLNKVKV
|||. .|.|..  ||.|   ..                                 ||||| .. ...  . | |||..|.||  |. ||||..  .|.  
knrnqeivpadqwrvelksesr.................................dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekita

IISLNSDDELNLRKWDIYWNN---LSYSNHTIKLQNTWENicniNGCVLRVFQVKKTapqndnisqdcdlphngdltsitmavsepfivyqlqyknwlds
|. |    | .  |   || .     | . |. |.. . .    |  . . . ...                                            
ivmltklqedlrikCsqyWPkrGsedyGeftvtlrketts....nsfiikelllrvn...........................................

CGVDMNDIIKLHKVKNSLLFNPQSFITSLekdvCKPDLIDDNNSElhldtANSSPLLVHCSAGCGRTGVFVTLdfLLSILSPTTnhSNKIDvwnmtqdlI
.    . ..  ..| . | ...|. | ||     | ...  .  |      . .|..||||.| |||.||...    |.    |  .  .|        .
ssakstlllahyqvidWleygeqaiinsl....vkfnkvislqte.....skkgPivvhCstgiGrtavfiaa..sasvkdalt..esvvd........v

FIIVNELRKQRISMVQNLTQYIACYEALLN
| .|. .|.||. .||.| ||   .|. |.
favvkimreqrmmavqtldqyklvhelvle

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 409-572 3.4e-21 70.6 In-house 42-174 (281) alignment
Range on Protein: 409-572
Range on HMM: 42-174/281.0
FTKNRYSNILPYEHSRVKLPHSPKPPavseasttetktdksypmcpvdaknhsckPNDYINANYLKltQINPDFKYIATQAPLPSTMDDFWKVITLNKVK
 .|||||||  |...|||. .. .                                .||||||...   .. . .|||||.|.|.....||...  .||.
vlknrYsnivaYDatrvkvtpneenk.............................ntDYinanfvp..gykgekeyiatqgPvPaslvafWqmvweqkvs

VIISLNSDDELNLRKWDIYWNNLS----YSNHTIKLQNTweniCNINGCVLRVFQVKKTAPQNDNISQ
.|. .  . | .  |   || . .    |.. |.| ...     . .  . |.|.....  .. ...|
aivmvtreieagklkChrYWPddnselkygdvtvkstae....eekatyierkfkleresgetreveq

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 229-293 3.7e-20 66.6 In-house 284-349 (349) alignment
Range on Protein: 229-293
Range on HMM: 284-349/349.0
TLNLRIN--IPPPNDSNKIFLQSLKKDLIHYSPNSLQKfFQFNMPADLAPNDTILPNWLKFCSVKEN
||.|...  .|..|.||||.||.|.||||....|.|.| ....|...||....|....||....|..
tldlllsileplqnesnkiklqallkDlisiivnelrk.qrismvqnlaqfiaiyealLkyfalkkd

0051082 (Phosphotyrosine protein) phosphatases II 466-734 9.7e-20 66.1 In-house 4-149 (151) alignment
Range on Protein: 466-734
Range on HMM: 4-149/151.0
DYINANYLKLTqinpdfkYIATQAPLPstmdDFWKVITLNKVKVIISLNSDDELNlrKWDIYWNNLSysnhtiklqntwenicningcvlrvfqvkktap
||||..|.          ......||.    ||.. .  ...|.|..|.|..| .  ..  |...|.                                 
dyinfsyvtgg.......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

qndnisqdcdlphngdltsitmavsepFIVYQLQYKNWLDSCgvdmndiiklhkvknsllfnpqsfitslekdvcKPDLIDDNNSELHLDTAN-SSPLLV
                           . |..... .| |                                    |...|  .. |.|  .. . |.||
...........................ievlhipildwpdpg.................................lplsfdavleflellldkkngpvlv

HCSAGCGRTGVFVTLDFLLsiLSpttnhsnkidvWNMTQdlifiIVNELRKQRISMVQNLTQYIACYEAL
|||||.||||..| |. .|  |            ... .     ...|.|..|  .||  .|.. .. ||
HCsaGkgRTGtlvalylml..lg...........vslee.....aleeyrlkrpgvvqpnqqflfqlfal

subfamily_PTPN12_pd Subfamily PTPN12 655-744 1.3e-19 65.1 In-house 203-283 (290) alignment
Range on Protein: 655-744
Range on HMM: 203-283/290.0
DTANSSPLLVHCSAGCGRTGVFVTLDFLLSILSPtTNHSNKIDVWNmtqdlifiIVNELRKQRISMVQNLTQYIACYEALLNYFALQKQI
 .....||.||||||.||||. ...|.  ..|    . ....||..        .| |||||| ..||   ||   |.|.....  . .|
qesedaPlvvhCsaGvGrtGtiiaidyvrellka.ekipeeldvfd........lvlelrkqraalvqtkeqyelvykavaelvqkelei

subfamily_PTPN23_pd Subfamily PTPN23 410-563 3.8e-19 63.6 In-house 45-165 (288) alignment
Range on Protein: 410-563
Range on HMM: 45-165/288.0
TKNRYSNILPYEHSRVKLPhspkppavseasttetktdksypmcpvdaknhsCKPNDYINANYLK-LTQINPDFkyIATQAPLPSTMDDFWKVITLNKVK
.|||. .||||.|.||||                                   . .||||| ..| |.   |||  |||||||.||. |||...  .|..
eknrsrdilPyDhnRvklr.................................gskDDYinAsfvkdlspgcPdf..iatqaPlqstlnDFWlmvyeqkss

VIISLNSDDELNLRKWDIYWNN-LSYSNHTIKLQNTWENICNINGCVLRVFQVKKT
||. | | .||.  | | || .    ...  .|. | ..  . . .| ||....  
viVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletl

subfamily_PTPRB_pd Subfamily PTPRB 654-743 1.3e-17 58.8 In-house 213-290 (293) alignment
Range on Protein: 654-743
Range on HMM: 213-290/293.0
LDTANSSPLLVHCSAGCGRTGVFVTLDFLLSILSPttnhSNKIDvwnmtqdlIFIIVNELRKQRISMVQNLTQYIACYEALLNYFALQKQ
 .||...|..|||||| ||||.|..|| ||. ..     .. .|        || || |||..| ..||. .|||  ....|...  ...
ektaskrPivvhCsaGvGRtGtfialdrllqaiee....edyvd........ifgivaelReeRnllvqtekqYifihqcvldllrkkee

subfamily_PTPN12_pd Subfamily PTPN12 461-563 1.5e-17 58.4 In-house 64-166 (290) alignment
Range on Protein: 461-563
Range on HMM: 64-166/290.0
SCKPNDYINANYLKLTQinPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSYSNH---TIKLQNTWENICNiNGCVLRV
. . .||||||..| ..   . .|||.|.||| |.||||..|   .|.... .    ||.  | . || .   ..    ....... |. .. .. ..| 
eeegsdYinanfikgve..gkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavd.ddflirt

FQVKKT
..|.. 
Lkveaq

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 655-736 1.6e-17 58.5 In-house 208-277 (288) alignment
Range on Protein: 655-736
Range on HMM: 208-277/288.0
DTANSSPLLVHCSAGCGRTGVFVTLDFLLSILSPttnhSNKIDVWNmtqdlifiIVNELRKQRISMVQNLTQYIACYEALLN
..|.. |..|||||| ||||.|..|| |.  .      ...||| .        .|..||||| ..||.|.||. .||.||.
nqadtgpiivhCsaGvGrtgtFialdalidavee....edyiDvag........tvaklRkqRallvqtlkqYefiyevlls

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 463-568 2.1e-17 58.2 In-house 72-174 (318) alignment
Range on Protein: 463-568
Range on HMM: 72-174/318.0
KPNDYINANYLKLTqiNPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSySNHTIKLQNTWENICNINGCVLRVFQVKK
.  |||||||.     . . .|||.||||| |..|||...   . .||. |    |   .| . || .   |..  ||. . ..  ...  ||| |.|..
egsDyinanyidGy..rrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskg.srsygklvvelkeevelsdyvlrefkvtr

TAPQND
|  .. 
teeees

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 464-738 3.5e-17 56.9 In-house 72-236 (392) alignment
Range on Protein: 464-738
Range on HMM: 72-236/392.0
PNDYINANYLKltQINPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNlrkwdiywnnlsysnhtiklqntwenicningcvlrvfqvkkt
 .||.|| |..   .. .  |||.|.| ....||||...  ..|  |. ..  .| .                                           
dsdylnasyip..sfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...........................................

apqndnisqdcdlphngdltsitmavsepfivyqlqyknwldscgvdmndiiklhKVKNSLLFNPQSFITSLEKDVCKPD-LIDDNNSELHLDTANSS-P
                                                       | ..        |    .||| |    .     |.. |  . . |
.......................................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythp

LLVHCSAGCGRTGVFVTLDFLLSilspTTNHSNKIDVWNmtqdlifiIVNELRKQRISMVQNLTQYIACYEALLNYF
|..||||| ||||| ...| ...     ....  .||.|        .| ..|..|  |||   ||   | |.|. .
liihcsagvgrtgvvisidsvva....hakktrmvdvfn........fvtnirrkrpymvqtkeqyafiygavledl

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 657-740 5.7e-17 56.7 In-house 214-285 (319) alignment
Range on Protein: 657-740
Range on HMM: 214-285/319.0
ANSSPLLVHCSAGCGRTGVFVTLDFLLSILSpttnHSNKIDVwnmtqdliFIIVNELRKQRISMVQNLTQYIACYEALLNYFAL
 .| |. |||||| |||| |..||  |  ..    . . .||        |..|..|| ||  |||.  ||. .|||||..   
tqsgPivvhCsaGvGRtGtfivldamlervk....eegvlDv........fstvsrlRtqRnimvqrpeqYkfiyealleavea

subfamily_PTPN13_pd Subfamily PTPN13 654-737 6.2e-17 56.8 In-house 198-268 (273) alignment
Range on Protein: 654-737
Range on HMM: 198-268/273.0
LDTaNSSPLLVHCSAGCGRTGVFVTLDFLLSILSPTTnhsnKIDVWNmtqdlifiIVNELRKQRISMVQNLTQYIACYEALLNY
|.| ...|..|||||| ||.|...|.| .| ...  .    ..|| .        ||..||.|| ..||   ||| .|.|.|. 
lqt.dagPivvhcsaGiGrsGtlitidvvlglierdk....efdvke........ivrklreqrqgvvqtkdqyifvykailev

0044763 (Phosphotyrosine protein) phosphatases II 462-738 6.5e-17 57.2 In-house 10-171 (178) alignment
Range on Protein: 462-738
Range on HMM: 10-171/178.0
CKPNDYINANYLKLTQINPDfKYIATQAPlpstmDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSYsnhtiklqntwenicningcvlrvfqvk
... ..  . |. ...| |.  |.... |      |... .  .....|..|....||.  | | ||                                 
snleglersdyinaseilpg.lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag............................

ktapqndnisqdcdlphngdltsitmavsepfivYQLQYKNWLDSCGVD-MNDIIKLHKVKNSLLfnpqsfitslekdvckpdliddnnselhldTANSS
                                  .| .. .. |..  | .  . ....  ...|                                . .
..................................iqylhipipDhgvpdllehflefvefieeal..............................dekgg

PLLVHCSAGCGRTGVFVTLDFLLSIlspttnhsnKIDVWNmtqdlifiIVNELRKQRIsMVQNLTQYIACYEALLNYF
| ||||||| ||.|..| .. ...          .... .        .....|..|  .|.|  |.  .||  | ..
pvlVHCsaGvgRsgtlvaaylmkkl.........glslee........aielvrerRp.ivpnpgqlrqLyefelrll

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 650-737 9.1e-17 56.3 In-house 215-290 (319) alignment
Range on Protein: 650-737
Range on HMM: 215-290/319.0
SELHLDTANSSPLLVHCSAGCGRTGVFVTLDFLLSILspttNHSNKIDVWNMtqdlifiiVNELRKQRISMVQNLTQYIACYEALLNY
. |.    .  ...||||||.|||||...|| ||. .    .. ...||.|.        |..||.||  .||.|.||  .| |||. 
rhltskenhranivvhcsaGvGrtGvyivldvlldrm....keekqvdvynf........vrdlrqqrntlvqdlvqykfiysallee

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 656-741 1.2e-16 55.7 In-house 210-283 (318) alignment
Range on Protein: 656-741
Range on HMM: 210-283/318.0
TANSSPLLVHCSAGCGRTGVFVTLDFLLSILspttNHSNKIDVWNMtqdlifiiVNELRKQRISMVQNLTQYIACYEALLNYFALQ
... .|..|||||| ||||||...| ||  .    .. . .||...        |..||.||  |||   ||. .|..||.. |  
ksgagpivvhCsaGvGrtGvfiavdilleri....kaealvDvfqt........vkqlreqrnlmvqtedqyefiydvllealasg

subfamily_PTPRA_pd Subfamily PTPRA 657-739 1.5e-16 55.2 In-house 226-296 (330) alignment
Range on Protein: 657-739
Range on HMM: 226-296/330.0
ANSSPLLVHCSAGCGRTGVFVTLDFLLSILspttNHSNKIDVWNmtqdlifiIVNELRKQRISMVQNLTQYIACYEALLNYFA
 ...|. |||||| |||| |..|| .|  .    .  .|.||..        .|..||.||  ||| . ||  .|..||.|. 
qsagpivvhcsaGvGrtGtfivldavlerv....kaerkvdvfe........fvkrlrlqrpqmvqtdeqyefiykvlleyyl

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 650-737 2e-16 55.4 In-house 179-254 (284) alignment
Range on Protein: 650-737
Range on HMM: 179-254/284.0
SELHLDTANSSPLLVHCSAGCGRTGVFVTLDFLLSILspttNHSNKIDVWNMtqdlifiiVNELRKQRISMVQNLTQYIACYEALLNY
. |.    . ....||||||.|||||...|| ||. .    .. ...||.|.        |..||.|| ..||.|.||  .| |||. 
rhltskenhranivvhcsagvgrtgvyivldvlldrm....keekqvdvynf........vrdlrqqrntlvqdlvqykfiysallee

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 655-740 3.2e-16 54.1 In-house 193-266 (270) alignment
Range on Protein: 655-740
Range on HMM: 193-266/270.0
DTANSSPLLVHCSAGCGRTGVFVTLDFLLSILSpttnHSNKIDVWNmtqdlifiIVNELRKQRISMVQNLTQYIACYEALLNYFAL
......||||||||| ||||....||. . .|.    ...|.|| .        |..||||.|. .||   ||   |.|...|   
eldkaePllvHcsaGvgRtGtlialDiavrlLe....etkkvdvla........iieelRkdRmalvqhpeqyeflykavveyaer

subfamily_PTPN9_pd Subfamily PTPN9 658-742 5.1e-16 53.5 In-house 222-294 (297) alignment
Range on Protein: 658-742
Range on HMM: 222-294/297.0
NSSPLLVHCSAGCGRTGVFVTLDFLLSILspttNHSNKIDVWNMtqdlifiiVNELRKQRISMVQNLTQYIACYEALLNYFALQK
.  |..|||||| |||| |.|||. || |    .. ...|| .         |. ||.||  ..|   ||  || |.|.|   .|
sgPPivvhcsaGiGrtGtfitldiclsrl....eevgtvdvvet........vkllrtqrafsiqtpeqyefcylavleyalelk

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 658-739 6.5e-16 53.4 In-house 215-284 (305) alignment
Range on Protein: 658-739
Range on HMM: 215-284/305.0
NSSPLLVHCSAGCGRTGVFVTLDFLLSILspttNHSNKIDVWNmtqdlifiIVNELRKQRISMVQNLTQYIACYEALLNYFA
.  ||||||||| ||||||...|  |  |    .. . .||..        ....||..|. |||.| ||  ...|| ..  
kgvpllVhCsagvgRtGvfiavdialerl....kkEevvdvfe........vlkqlRskrmkmvqtldqYvflhdaldelit

subfamily_PTPN6_pd Subfamily PTPN6 458-605 7.3e-16 53.0 In-house 74-198 (306) alignment
Range on Protein: 458-605
Range on HMM: 74-198/306.0
KNHSCKPNDYINANYLKLTQINPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSYSNHT--IKLQNTWEniCNINGCVL
|..| . .|||||||.|  . . | .|||||  |..|. |||...  .. .||. .  . | .  |   || . . ....  |...|. |   . .  .|
kepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvse..ksladYil

RVFQVKKTapqndnisqdcdlphngdltsitMAVSEPFIVYQLQYKNWLD
| ..|.|.                          .|   |.|...|.| |
Relsvskk.......................kkkkeerevfqyhfksWPd

subfamily_PTPN13_pd Subfamily PTPN13 452-564 1.7e-15 52.0 In-house 46-161 (273) alignment
Range on Protein: 452-564
Range on HMM: 46-161/273.0
MCPVDAKNHSCKPND-YINANYLKLTQINPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSysNHTIKLQN----TWEN
. |.|.     . .  ||||...|..  .  ..|||.| ||| |..|||...   |..||. . .. | .  | . || .    |...|..|    . ..
vlPydetrvklgdeggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesk..nkklkvsnrlevellk

ICNINGCVLRVFQVKKTA
. . .| |.| ..||...
vqkldgfvvralavkdse

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 656-739 2e-15 51.7 In-house 172-243 (250) alignment
Range on Protein: 656-739
Range on HMM: 172-243/250.0
TANSSPLLVHCSAGCGRTGVFVTLDFLLSILspttNHSNKIDVWNmtqdlifiIVNELRKQRISMVQNLTQYIACYEALLNYFA
 |...|..|.|||| ||.| |...| .|  |    ......||..        ... |||.|. .|. |.||. .||..|..  
qagnaPvivqCsaGvgrsGafiaidavlerl....kkekvvdvfk........vikvlrkdrphavesleqyvfvyeiilkald

subfamily_PTPRB_pd Subfamily PTPRB 462-563 2.1e-15 51.5 In-house 76-175 (293) alignment
Range on Protein: 462-563
Range on HMM: 76-175/293.0
CKPNDYINANYLKLTQINpdFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSYSNHTIKLQNTWENICNINGCVLRVFQVK
 . .|||||||..  . .   ..|||| |||.|.||||...  .|...|. |    |    | . || . . .    ... |  .  . .  |.| ....
esgsDYinanyipgynsp..refiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkie

KT
|.
ke

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 406-568 3e-15 51.0 In-house 43-171 (287) alignment
Range on Protein: 406-568
Range on HMM: 43-171/287.0
IQ--SFTKNRYSNILPYEHSRVKLPhspkppavseasttetktdksypmcpvdaknhsCKPNDYINANYLKltQINPDFKYIATQAPLPSTMDDFWKVIT
|      |||...||...  || |                                   . .||||| ...    . . ..|....|. .|. .|||.| 
iasqnkdknRltqilvpdnyrvllk.................................gehpdyinavfid..gykekkafiiaesPmfntarnfWklid

LNKVKVIISLNSDDELNLRKWDIYWNNLS---YSNHTIKLQNtwENicNINGCVLRVFQVKKTAPQND
 ..|..|. |  . | . ..   || . .   . ...|.| |  |.    .|.. | ..||..  ..|
drnvtaivmlcqekendeevcyqyWpeeksvvlGeynielln..ee..vnagyierklevknknkagd

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 459-560 3.7e-15 51.0 In-house 78-179 (298) alignment
Range on Protein: 459-560
Range on HMM: 78-179/298.0
NHSCKPNDYINANYLKLTQINPdfKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNN---LSYSNHTIKLQNTwENICNINGCVL
... .  ||||| .|.  . ..   .|||||||..|. |||...| .....|. |..  ||.  |.  || .     | . |..|... |.  ..  . |
edadeesdYiNAsflhaykgrn..afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllsk.eefadlivrkl

RVFQV
 | . 
kvskk

subfamily_PTPN6_pd Subfamily PTPN6 650-745 3.8e-15 50.7 In-house 218-304 (306) alignment
Range on Protein: 650-745
Range on HMM: 218-304/306.0
SELHLDTANSSPLLVHCSAGCGRTGVFVTLDFLLSILSPTtNHSNKIDVWNMtqdlifiiVNELRKQRISMVQNLTQYIACYEALLNYFALQKQIK
 . .| .|.. |..|||||| |||| |. .| ||.... .     .||. ..        |. .|.||  .||  .||   |.|. .|   .|...
kqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekk.gldadidiqkl........vksvreqrsglvqteqqykfvykaikkyietkkkle

subfamily_PTPN3_pd Subfamily PTPN3 592-736 4.3e-15 50.4 In-house 170-273 (280) alignment
Range on Protein: 592-736
Range on HMM: 170-273/280.0
PFIVYQLQYKNWLDSC-GVDMNDIIKLH-KVKNSLlfnpqsfitslekdvckpdliddnnselhldTANSSPLLVHCSAGCGRTGVFVTLDFLLSILspt
   . |||| .| |..   | .|....  .|..                                 .....|..|||||| |||||...|.  |...   
erkilqlqylaWpdhgvPddsadflefvervrklr...............................sgkeePvvvhCsaGigrtGvlilletalali...

tNHSNKIDVWNmtqdlifiIVNELRKQRISMVQNLTQYIACYEALLN
 ...... . .        || ..| || ..||. .||    ||.|.
.eaaepvypld........ivrtmrdqramlvqtasqykfvCeailk

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 654-739 6e-15 50.1 In-house 212-285 (297) alignment
Range on Protein: 654-739
Range on HMM: 212-285/297.0
LDTANSSPLLVHCSAGCGRTGVFVTLDfllSILSpTTNHSNKIDvwnmtqdlIFIIVNELRKQRISMVQNLTQYIACYEALLNYFA
 .. ...||||||.|| |||||..|.|   |...   .. ...|        || .|. ||..|  .||   ||   |.|.|... 
fsqnaegPllvhclaGvGrtgvlltid...svva.eakrekevd........ifglvkklrqerpylvqtkeqykfvyvavleall

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 648-738 1.4e-14 49.0 In-house 210-288 (325) alignment
Range on Protein: 648-738
Range on HMM: 210-288/325.0
NNSELHLDTANSSPLLVHCSAGCGRTGVFVTLdflLSILSPTTNHSnKIDvwnmtqdlIFIIVNELRKQRISMVQNLTQYIACYEALLNYF
 .  .. .|  |.|.||||||| ||||||..|    |.|    ..| ..|        ||  |. |||.| |||.   ||| .|||| ...
vservtantkastpilvhcsaGvGrtGvfisl...ysalakviees.rvd........ifgfvkklrkdrpsmvetvdqyiliyealveay

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 465-569 1.5e-14 48.8 In-house 79-177 (297) alignment
Range on Protein: 465-569
Range on HMM: 79-177/297.0
NDYINANYLKLTQInpdfKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLrKWDIYWNNLSYSNhTIKLQNTWENICNINGCVLRVFQVKKTA
 ||.|| ..|  .     ..|.|| | ..|..|||...  ..|..|. || |.| .  |   || . . ..   ..  . . . . .| . | ..|.| .
sDyvnasfvkgnkh....rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt.fGdvsvvllsvsereGfikrelevtkgk

PQNDN
... .
akarr

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 654-739 1.7e-14 48.4 In-house 207-280 (315) alignment
Range on Protein: 654-739
Range on HMM: 207-280/315.0
LDTANSSPLLVHCSAGCGRTGVFVTLDFLLSilspTTNHSNKIDVWNMtqdlifiiVNELRKQRISMVQNLTQYIACYEALLNYFA
 .|.. ....|||||| |||| |.||| .|       .  | |||.|.        .. .|..|| ||| . ||   |.|||. | 
hhtnsvgaivvhcsaGvGrtGtfitldavld....qaeaenaidvynf........itgvrqnrikmvqvaeqyqfiydalletfv

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 459-564 2.1e-14 48.4 In-house 68-172 (305) alignment
Range on Protein: 459-564
Range on HMM: 68-172/305.0
NHSCKPNDYINANYLKLTqiNPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSYS-NHTIKLQNTWENICNINGCVLRV
..| . .|||||.|..    .   |||..|.||..|..|||..|   ||..|. |    | .  |   || .     ..  ... . ..  .... . | 
keslddsdyinasyvdgy..krkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRk

FQVKKTA
... .  
lkisied

subfamily_PTPN3_pd Subfamily PTPN3 463-567 2.3e-14 48.0 In-house 63-169 (280) alignment
Range on Protein: 463-567
Range on HMM: 63-169/280.0
KPNDYINANYLKLTQIN--PDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSYSNHTIKLQNTWENICNINGCVLRVFQV
 ..|||||||...         .||||| ||..|. |||...  .|...|. | .  |    |   || . . . .  ... . |.  . . .||| . .
setdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvl

KKTAPQN
|... ..
kdketke

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 657-740 2.4e-14 48.1 In-house 206-278 (281) alignment
Range on Protein: 657-740
Range on HMM: 206-278/281.0
ANSSPLLVHCSAGCGRTGVFVTLDFLLSILSpttNHSNKIDVWNmtqdlifiIVNELRKQRISMVQNLTQYIACYEALLNYFAL
 .  ||..||||| ||||....|| |.. ..   .. ...|| .        .|.||||.|  ||| ..||   | |.|...  
ktkaplvihCsaGvGrtGtyialDrlvkave...aeleeldvka........vvaelrkernlmvqtvvqyefvykavldaldk

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 656-739 3.7e-14 47.7 In-house 220-291 (298) alignment
Range on Protein: 656-739
Range on HMM: 220-291/298.0
TANSSPLLVHCSAGCGRTGVFVTLDFLLSilspTTNHSNKIDVWNMtqdlifiiVNELRKQRISMVQNLTQYIACYEALLNYFA
 |  .|..|.|||| ||.| |. .| .|       ......||...        |. |||.|. .||  .||. .||| |....
qagnkpvivqCsaGvgRsGtfiaidsvle....rvkkeqvvDvfqv........vkvlRkkrpgavqteeqYvfiyeavleald

subfamily_PTPRK_pd Subfamily PTPRK 658-736 1.2e-13 45.6 In-house 209-275 (314) alignment
Range on Protein: 658-736
Range on HMM: 209-275/314.0
NSSPLLVHCSAGCGRTGVFVTLDFLLSILspttNHSNKIDVWNmtqdlifiIVNELRKQRISMVQNLTQYIACYEALLN
.  ...||||||.||||.|...| .| ..    .. . .||.|        .| .||.... ||.   ||. .|...|.
eaGrivvhCsaGaGrtGtfiaidivldmi....eregvvdvfn........avktlrsrkvnmveteeqykfiydvile

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 464-544 1.3e-13 45.6 In-house 47-124 (270) alignment
Range on Protein: 464-544
Range on HMM: 47-124/270.0
PNDYINANYLKLTQINPDfKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNlsYSNHTIKLQNTW
   ||||||..  . ..  ||||...|||.|. .||..|  .||. |. .    | . .| . || .   .....||..  
ataYinAnyvrGfdgekk.kYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpa..epkekvkledgk

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 460-563 1.8e-13 45.2 In-house 70-171 (288) alignment
Range on Protein: 460-563
Range on HMM: 70-171/288.0
HSCKPNDYINANYLKLTQINpdFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLS----YSNHTIKLQNTweniCNINGCVL
.  . .|||||.|.. .. .   ||||||.||..|..|||...  ||.. |. |..  | . .| . || .      | . |..|...     . .  ||
eeeagaDYinasyidgekkk..kkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlves....keledfvl

RVFQVKKT
| . ..|.
rklllekk

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 460-567 3.3e-13 44.2 In-house 71-175 (290) alignment
Range on Protein: 460-567
Range on HMM: 71-175/290.0
H-SCkPNDYINANYLKltQINPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNL---SYSNHTIKLQNtwENICNinGCVL
|  | .|.|||| |.|  . . . .|||||.|...|. ||||.|  .|| .|. | .  | .  |   || .    .| . .|||.|  |...|  . . 
hkDC.tneyinAcyik..gykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsiklln..eetln..eyie

RVFQVKKTAPQN
| ..||..  ..
rklevknknsag

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 457-605 5.9e-13 43.2 In-house 62-200 (301) alignment
Range on Protein: 457-605
Range on HMM: 62-200/301.0
AKNHSCKPNDYINANYLKltQINPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNL-SYSNHTIKLQNTWENICNINGCVL
 .| . . ..||||.|..   ..   |.||.|.|. .|. |||..|  .|.  |. .   .|    |   ||.|    |..  ....|  | ...   |.
kpnldlcqreyinasyid..gysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvi

RVFQVKKTAPQNdnisqdcdlphNGDLTSITMAVS--EPFIVYQLQYKNWLD
| ..|| .   |           || . .     |  ..  | |||  .| .
rqlnvkiqdgsn...........ngyierkfkvksdksswdvlqlqvtdWpq

0048076 (Phosphotyrosine protein) phosphatases II 594-736 6.5e-13 44.1 In-house 46-141 (145) alignment
Range on Protein: 594-736
Range on HMM: 46-141/145.0
IVYQLQYKNWLDSCGVDM-NDIIKLHKVKNSLLFNpqsfitslekdvckpdliddnnselhldtanSSPLLVHCSAGCGRTGVFVTLDFLLSilspttnh
 ..|..| .| | .  |. ...... .  ...| .                                 | |||||||.||||..| .. .|.        
lgiqylylpwpDhgvpdllellleflefieealke...............................ggpvlVHCsaGvgRtgtlvaaylmll........

snkidvWNMTqdlIFIIVNELRKQRISMVQNLTQYIACYEALLN
       ...   .. .....|.||  .|.|  |.. .||..| 
......lgvs...leealelvrsqrpgavpnpgqlrflyefele

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 458-543 9.4e-13 42.9 In-house 30-115 (250) alignment
Range on Protein: 458-543
Range on HMM: 30-115/250.0
KNHSCKPNDYINANYLKLTQINpdFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRkWDIYWN---NLSYSNHTIKLQNT
|... |  ||||| .|.  . .    .||||.||..|. |||.... .|...|. |..  | .   .  ||       | . |..| ..
kekgdkesdyinasflhgyder..kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaekyGdvtvsllsk

0048179 (Phosphotyrosine protein) phosphatases II 582-732 1.1e-12 43.4 In-house 48-139 (144) alignment
Range on Protein: 582-732
Range on HMM: 48-139/144.0
LtsitmavsepfiVYQLQYKNWLDSCGVDM-NDIIKLHKVKNSLlfnpqsfitslekdvckpdliddnnselhldTANSSPLLVHCSAGCGRTGVFVTLD
             ..|... .| | .  |. ...... .  ...                                ... | |||||||.||||..|...
e............giqylhlpwpDhgvpdllellleflefieea...............................leeggpvlVHCsaGvgRtgtlvaay

FLLsilspttnhsnkidVWNMTqdlIFIIVNELRKQRISMVQNLTQYIACYE
 ..              . ...   .. .....|..|  .|.|  |.. ..|
lmk..............klgls...leealalvrsrrpgavpnpgqlrfLle

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 464-563 1.5e-12 42.2 In-house 75-172 (325) alignment
Range on Protein: 464-563
Range on HMM: 75-172/325.0
PNDYINANYLKlTQINPDfKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNlRKWDIYWNNL-SYSNHTIKLQNTWENICNINGCVLRVFQVKK
  |||||.||. .... |  ..|.||||..|..|.|...   .  |.. ||  |. .  .  .|| .  . | .   |.     | .|   | ||..||.
ssdyinasylr.ddkkkd.vflaaqaPltatindlWrlvldWrcsvvvvlneldlgk.drcavywpkemgksktfGglevklrtieeisdyvhrvldvkq

T
.
v

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 655-736 1.6e-12 41.6 In-house 208-277 (439) alignment
Range on Protein: 655-736
Range on HMM: 208-277/439.0
DTANSSPLLVHCSAGCGRTGVFVTLDFLLSILspttNHSNKIDVWNmtqdlifiIVNELRKQRISMVQNLTQYIACYEALLN
|. .  |..|||||| ||||  ..||  |  |    .  ||.|.          ||. |||||  |||.| ||.  |.|.|.
dkeeygpvvvhcsagvGrtGtiialdialeql....klenkvdikg........ivkvlrkqrkqmvqalcqyvfiynavle

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 463-563 1.7e-12 42.1 In-house 74-171 (319) alignment
Range on Protein: 463-563
Range on HMM: 74-171/319.0
KPNDYINANYLKltQINPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSYSNHTiKLQNTWENICNINGCVLRVFQVKK
.  |||||...     .   |.|||||||  |..|||...  ... ... |. . |    |   ||..  . .   .|  | |.  . .. . | ....|
egsdyinasfid..gyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyG.rlivtleeeeeledyiirklklnk

T
 
k

subfamily_PTPRK_pd Subfamily PTPRK 464-609 1.7e-12 41.8 In-house 70-188 (314) alignment
Range on Protein: 464-609
Range on HMM: 70-188/314.0
PNDYINANYLKLTQinPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSYSNHTIKLQNTWENicNINGCVLRVFQVKKt
 .|||||...   .     ..|.|| ||..|. |||...  ..   |. |.   |    |   || . .     ||..    .    .  | |.|.|.| 
ssdyinaalidsyk..rpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtevygdikvelvete..llaelvvrifrvek.

apqndnisqdcdlphngdltsITMAVSEPFIVYQLQYKNWLDScGV
                     .. ...|  .| |.|. .| |  .|
.....................largqeeirevrqfqflgWpdh.dv

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 464-530 2.1e-12 41.5 In-house 58-124 (297) alignment
Range on Protein: 464-530
Range on HMM: 58-124/297.0
PNDYINANYLKLTQINPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNN
 .|||||.|. . . . |.||| .| || .|.||||.... . |.||. .    |    |   || .
erdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywps

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 657-740 4.1e-12 40.6 In-house 208-279 (315) alignment
Range on Protein: 657-740
Range on HMM: 208-279/315.0
ANSSPLLVHCSAGCGRTGVFVTLDFLLSilspTTNHSNKIDVWNmtqdlifiIVNELRKQRISMVQNLTQYIACYEALLNYFAL
 .  .|||||||| |||||....|  ..      .... .||.|        .|..||..|. .||   .|   |.|.|...  
kkefsllvhcsaGvGrtGvvisidevva....qikrtrsvdvfn........fvknlrakrpylvqteeeyafiydavledllw

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 660-739 7.5e-12 39.1 In-house 210-277 (515) alignment
Range on Protein: 660-739
Range on HMM: 210-277/515.0
SPLLVHCSAGCGRTGVFVTLDFLLSilspTTNHSNKIDVWNmtqdlifiIVNELRKQRISMVQNLTQYIACYEALLNYFA
 ||..||||| |||||....|  ..      . .. .||.|        .|. .|..|  .||   ||   |.|.|... 
hpliihcsaGvGrtGvvisidsvva....hakttrmvdvfn........fvtnirqkrpylvqtqeqyafiygavledll

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 411-531 1.1e-11 39.5 In-house 6-94 (237) alignment
Range on Protein: 411-531
Range on HMM: 6-94/237.0
KNRYSNILPYEHSRVKLPHSPKPpavseasttetktdksypmcpvdaknhsckpNDYINANYLKLTQINPDfKYIATQAPLPSTMDDFWKVITLNKVKVI
||||.||  |.|||| |  .                                   |||||.|||  .  |  ||||.| || |. ||||...  .|  ||
knrygnivaydhsrvvlkgagsg...............................sdyinatylkgfdgtpk.kyiaaqgplesscddfwqmvwqekcsvi

ISLNSDDELNLRKWDIYWNNL
. |    | |  |   || . 
vmltgliegnelkchkywpst

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 465-530 1.1e-11 39.1 In-house 72-135 (315) alignment
Range on Protein: 465-530
Range on HMM: 72-135/315.0
NDYINANYLKltQINPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNN
.||||| |.|   .. |  |||.|.||....||||...  .||  |. ..  .| .  |   || .
sdyinasyik..svdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPd

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 590-736 1.5e-11 38.7 In-house 161-293 (297) alignment
Range on Protein: 590-736
Range on HMM: 161-293/297.0
SEPFIVYQLQYKNWLDSCGV-DMNDIIKLHKVKNSLLFNPQSFITSLEKDVCkpdLIDDNNSELHLDTANSSPLLVHCSAGCGRTGVFVTLDFLLSILSp
||   |   |. .| |     |..|. ...    |       ... .|  ..   ..  .   |. .   . .|||||||| ||.|| |  | .|..|  
sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemfta...mvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklr.

ttnhSNKIdvWNmtqdlIFIIVNELRKQRISMVQNLTQYIACYEALLN
     ..|   .     .  |.. ||.||  .|| | |.  .|.| |.
....kkri..pd.....vaailsilreqrarlvqtleqfellydavlk

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 445-541 1.6e-11 38.7 In-house 60-153 (315) alignment
Range on Protein: 445-541
Range on HMM: 60-153/315.0
KTDKSYPMCPVDAK-NHSckpnDYINANYLKltQINPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWN--NLSYSNHTIKLQ
 .||| .  |.  . .||    ||.|||...    |   .|||.|.|......|||...  ...  |. |..  | . || . ||   .. | . |. ..
aydksrvqlpllendphs....dyvnanfid..GynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviyGkitvtrk





subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 460-548 1.6e-11 38.4 In-house 75-162 (305) alignment
Range on Protein: 460-548
Range on HMM: 75-162/305.0
HSCKPNDYINANYLKLTQInPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSYSNHTIKLQNTWENIC
.   | ||| |||.    | |. ..|..| ||  |.|.|| ..  |||. |. |    ||   |   ||      ....|     ||. 
dkpspsdyihanyvgcpmi.pekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvs

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 650-747 3.3e-11 37.5 In-house 201-286 (287) alignment
Range on Protein: 650-747
Range on HMM: 201-286/287.0
SELHLDTANSSPLLVHCSAGCGRTGVFVTLDFLLSILSPTTNhsnkIDVWNmtqdlifiIVNELRKQRISMVQNLTQYIACYEALLNYFALQKQIKNA
 ||  |...  ||.||...| ||.|.....  |.| |  . .    .|| .        .|  ||..| ..||   |.   ||||  |.  . |. .|
ielardasevGPlvvhddvGiGrsGillatlvlvsrledlGr....vdvaa........vvirlreyraalvqavvqlrllyealvtyyktnpqlyva

subfamily_ptpA1_pd Subfamily ptpA1 464-586 3.5e-11 37.5 In-house 74-189 (418) alignment
Range on Protein: 464-586
Range on HMM: 74-189/418.0
PNDYINANYLKLTQinPDfKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSYSNHTIKLQNTWENICNINGCVLRVFQvkkt
 .|||||||.  .   |  ..|.|| ||| |. |||...  |....|. |. . |    | | || .    ..     |  | .   .  .. | |    
gsdyinanyidgay..pk.qfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviq....

APQNDNISQDCDLPHNGDLTSIT
 |. . |...  |  .|.   ||
dpereiitrnirltfegetrdit

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 658-740 4.5e-11 37.2 In-house 191-259 (267) alignment
Range on Protein: 658-740
Range on HMM: 191-259/267.0
NSSPLLVHCSAGCGRTGVFVTLDFLLSILspttNHSNKIDvwnmtqdlIFIIVNELRKQRISMVQNLTQYIACYEALLNYfaL
 . ||.|.||.| ||.| |...|  |  .     . .  |        ||  . ..|.|||..|. . .|| ..| | .|   
gnrPlvvacsdGvGrsGtflvidsqlera....ktegvsd........ifdflrkirsqriglvdtkeryiyihellaey..a

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 465-531 4.7e-11 36.5 In-house 71-135 (515) alignment
Range on Protein: 465-531
Range on HMM: 71-135/515.0
NDYINANYLKltQINPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNL
.||.|| |..   .. |  |||.|.|.....||||...  ..|  |. ..   | .  |   || . 
sdyfnasyip..sfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdk

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 465-529 6.6e-11 36.5 In-house 65-127 (287) alignment
Range on Protein: 465-529
Range on HMM: 65-127/287.0
NDYINANYLKltQINPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWN
 |||||||.     . | ..||.|.|...|. |||...  ... ..| .  . |    |   || 
sdyinanyva..sytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywP

subfamily_PTPN9_pd Subfamily PTPN9 462-562 7.3e-11 36.6 In-house 67-166 (297) alignment
Range on Protein: 462-562
Range on HMM: 67-166/297.0
CKPNDYINANYLKLTQINPdfKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWN-NLSYSNHTIKLQNTWENICNINGCVLRVFQV
 .  ||||||..   . .    .|||| ||. |..|||...  ..| ||.      |   .|   ||. .   |..  .|. .  .. . .  . ||...
deasdyinanfvdGykqkk..afiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvlei

KK
|.
kn

subfamily_PTPN1_pd Subfamily PTPN1 464-605 7.5e-11 36.3 In-house 55-174 (290) alignment
Range on Protein: 464-605
Range on HMM: 55-174/290.0
PNDYINANYLKLTQINPdfKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSYsNHTIKLQNTWENICNINGCVLRVFQVKKT
 ||||||. ..| ...   .|| || |||.|.| ||...  .| | .. ||   | .  |   || .    .....|..|  ..  |.  . . ..|.. 
dndyinaslveleeakr..syiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgee.ekellledtklkvkliseerksyytvrll

APQNdnisqdcdlphngdltsitMAVSEPFIVYQLQYKNWLD
  .|                   .   |   ...  |  | |
elen...................lktqetreilhfhyttwpd

subfamily_PTPN23_pd Subfamily PTPN23 658-737 9.9e-11 36.0 In-house 211-279 (288) alignment
Range on Protein: 658-737
Range on HMM: 211-279/288.0
NSSPLLVHCSAGCGRTGVFVTLdflLSILSPTtNHSNKIDvwnmtqdLIFIIVNELRKQRISMVQNLTQYIACYEALLNY
   ||.|||||| ||||||  .    ...  . .. | .         |  .|. ||.||  |||. .|.  .||| |..
sktPlvvhCsaGvgRtgvfalv...yaavrel.ekgngll.......diiqvvsrlreqRrfmvqekeqlkfsyeavlea

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 645-737 1.9e-10 34.6 In-house 115-193 (440) alignment
Range on Protein: 645-737
Range on HMM: 115-193/440.0
IDDNNSElhLDTANSSPLLVHCSAGCGRTGVFVTLDfllSILSpTTNHSNKIDvwnmtqdlIFIIVNELRKQRISMVQNLTQYIACYEALLNY
|.| |     . | ..|||||||||.||||| ...|   |||   ...|..||        || ..| .|..|  |||   ||   .||.|. 
iqdvnes..qekagngpllvhcsagagrtgviiavd...silr.eakrsdqid........ifsfinsmrnnrpqmvqtpeqyafvheavleg

subfamily_PTPRN_pd Subfamily PTPRN 460-537 2.1e-10 34.8 In-house 79-155 (297) alignment
Range on Protein: 460-537
Range on HMM: 79-155/297.0
HSCKPNDYINANYLklTQINPD-FKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSYSNHT
 | . .|||||  .  .. .|    |||||.||.||. |||...  . | ||..| . .| .... . || .   . . 
asaeksdyinasai..ldhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyh

subfamily_egg_pd Subfamily egg 410-530 2.8e-10 34.4 In-house 42-129 (307) alignment
Range on Protein: 410-530
Range on HMM: 42-129/307.0
TKNRYSNILPYEHSRVKLphspkppavseasttE-------TktdksypmcpvdaknhsckpnDYINANYLKLTQINPDFkyIATQAPLPSTMDDFWKVI
.| |   .   . |||||               |                             |.| ||..|   .  .|  | .||||  |.||||...
ekarskrvhckdssrvkl...............elrrGqyld.....................dfihanrvkGkpllnef..ilaqaplkntvddfwrmv

TLNKVKVIISLNSDDELnlRKWDIYWNN
  ..|. |. |.|  |    . . || .
fqeevqyivmltsrkes..erceyywpk

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 657-739 4e-10 34.2 In-house 207-278 (307) alignment
Range on Protein: 657-739
Range on HMM: 207-278/307.0
ANSSPLLVHCSAGCGRTGVFVTLDFLLSILSPTTNhsnkidVWNMTQdlifiIVNELRKQRISMVQNLTQYIACYEALLNYFA
 .  |..|||||| ||.|  |.. ..   .    |        .| .     .|.|||.||   .|.  ||.  .  ||.|| 
ydtnpvvvhcsaGvGrsGtivaislvqdkmiaGin......ckdmkk.....lveelrsqrhyaiqteaqylylhrvlleyfl

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 465-565 7.7e-10 33.7 In-house 53-144 (284) alignment
Range on Protein: 465-565
Range on HMM: 53-144/284.0
NDYINANYLKLTQINpDfKYIATQAPLPSTMDDFWKVITLNKVKVIISLNsddelnLRKWDIYWNN---LSYSNHTIKLQNTWENICningCVLRVFQVK
 ||||| ...  | . | |||||| ||. |..|||..|   ..  |. |         |   || .     . .  .|..   |        |.| ... 
sdyinasfitGyqrk.d.kyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveesee....yvvrdiels

KTAP
. . 
edgk

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 454-513 8.3e-10 32.7 In-house 58-116 (347) alignment
Range on Protein: 454-513
Range on HMM: 58-116/347.0
PVDAKNHS-CKPNDYINANYLKLTqiNPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISL
| ..||    ... |||| ..|.   | . .|| || |||.|. ||||.... ||  ....
peksknsraddvetyinashikfd..naskeyiltqyplpdtvrdfwkmvsvtkvtqvvti

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 659-740 9.1e-10 33.0 In-house 211-280 (287) alignment
Range on Protein: 659-740
Range on HMM: 211-280/287.0
SSPLLVHCSAGCGRTGVFVTLDFLLSilspTTNHSNKIDVwnmtqdliFIIVNELRKQRISMVQNLTQYIACYEALLNYFAL
 ....||||.. ||...|.  .  .      ..    |||        | .... | |.  .||  .||.  ....|.|   
ntsivvhCsdtvGrsamfcaaattin....kckteGviDv........fqvlksqriqkpgsvqtveqykfindivleylds

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 465-565 9.6e-10 33.3 In-house 89-180 (319) alignment
Range on Protein: 465-565
Range on HMM: 89-180/319.0
NDYINANYLKLTQInPDfKYIATQAPLPSTMDDFWKVITLNKVKVIISLNsddelnLRKWDIYWNN---LSYSNHTIKLQNTWENICningCVLRVFQVK
 ||||| ...  |  .| ||||.| ||. |..|||..|   ..  |. |         |   || .     . .  .|..   |        |.| ... 
sdyinasfvtGyqr.kd.kyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetae....yvvrdiels

KTAP
. . 
edgk

subfamily_PTPRA_pd Subfamily PTPRA 463-561 9.9e-10 32.8 In-house 84-179 (330) alignment
Range on Protein: 463-561
Range on HMM: 84-179/330.0
KPNDYINANYLKLTQinPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNN---LSYSNHTIKLQNTWEnicnINGCVLRVFQ
.  ||||| ...  .     |.||.| |.  |..|||..|   |   |. |   .| .  |   || .   ..| | ....... .    ..   .| | 
eesdyinasfidGyk..ekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetv....lvdytvrkfl

VK
|.
vq

subfamily_CG7180_pd Subfamily CG7180 655-741 1.1e-09 32.3 In-house 219-293 (296) alignment
Range on Protein: 655-741
Range on HMM: 219-293/296.0
DTANSSPLLVHCSAGCGRTGVFVTLDFLLSILspttNHSNKIDVwnmtqdliFIIVNELRKQRISMVQNLTQYIACYEALLNYFALQ
.  . .|..|..| | .|.||....|  |  .    .. ...||        |  |  ||..|  .|.| ..|  .|. ||...  .
edpeegPvvvvssdGasRsGvylaidanlelv....ekeeevdv........FeavktlrrsRpqLvenveeYkyiYdvlleavlcn

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 659-739 1.2e-09 32.5 In-house 216-284 (290) alignment
Range on Protein: 659-739
Range on HMM: 216-284/290.0
SSPLLVHCSAGCGRTGVFVTLDFLLSilspTTNHSNKIDvwnmtqdlIFIIVNELRKQRISMVQNLTQYIACYEALLNYFA
  ...||||.. ||..||....  .      ..    ||        .| .....| |.  .||   ||   .. .|.|. 
ntsivvHCSdtvgrsavfcaaattin....kcktegvid........vfqvlksqRiqkpgsvqtvqqyqgifqivltyld

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 464-571 2.2e-09 31.7 In-house 66-163 (307) alignment
Range on Protein: 464-571
Range on HMM: 66-163/307.0
PNDYINANYLKlTQINPDfKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSYSNHTIKLQNtwenicniNGCVLRVFQVKKT
  ||| ||||  . |.|  |.|..| || .|. .|| ..  .||. .| |    ||   | . ||      . .   ..        |   .  . .|| 
asdyihanylg.iaikpk.kficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeap........ntisvanlgakkl

APQNDNIS
||..| | 
apdedlin

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 659-743 2.3e-09 31.4 In-house 226-298 (301) alignment
Range on Protein: 659-743
Range on HMM: 226-298/301.0
SSPLLVHCSAGCGRTGVFVTLdfllSILSPTTNHSNKIDVwnmtqdliFIIVNELRKQRISMVQNLTQYIACYEALLNYFALQKQ
 .|..||||.. .|.||....    ||          .||        | ... .|...  .|. | ||.  |...  |..|.. 
ggpvvVHCSdtVsrsGvYcsv....siglEQckaegVVdv........fqvtkavrrskpgaVtTLeqytsiydvidmylqlnst

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 658-739 3e-09 31.0 In-house 215-284 (290) alignment
Range on Protein: 658-739
Range on HMM: 215-284/290.0
NSSPLLVHCSAGCGRTGVFVTLDFLLSILSpttnHSNKIDVWNmtqdlifiIVNELRKQRISMVQNLTQYIACYEALLNYFA
 | |. |||||| |||| ||...  | ||     .  ..|. .        .|  ||. |.. ||  .||.|  |.||..  
asGpvvvhcsaGiGrtGtfvaievglqill....dGkeldlld........lvralrnsrlnsvqvdiqylalveilldlGk

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 659-741 3.2e-09 30.8 In-house 221-292 (305) alignment
Range on Protein: 659-741
Range on HMM: 221-292/305.0
SSPLLVHCSAGCGRTGVFVTLDFLLSILSpttnhSNKiDVWNMTQdlifiIVNELRKQRISMVQNLTQYIACYEALLNYFALQ
  |..|||||| ||||  |.....|  ..      || ..  | .     .|. || ||   .||  ||.  .  .||||  .
kvpivvhcsagigrtgtivaieyilekia.....enk.pcppmpe.....lvkalrdqrafsiqndvqylfihrvmlnyflek

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 658-744 3.3e-09 30.9 In-house 218-293 (305) alignment
Range on Protein: 658-744
Range on HMM: 218-293/305.0
NSSPLLVHCSAGCGRTGVFVTLDFLLSILSpttnHSNKIDvwnMTQDlifiIVNELRKQRISMVQNLTQYIACYEALLNYFALQKQI
   |. |||||| ||||  | |...|  |       ..|.    |.     |.. .|.||   .|  .||.  .. .||||  .| .
skgpivvhcsagigrtgsvvmleyildqll....agqiie...dtdk....ilqkireqrnnsiqtdaqylfvhqvilnyfrkkkll

subfamily_CG42327_pd Subfamily CG42327 455-530 1.1e-08 29.2 In-house 46-120 (319) alignment
Range on Protein: 455-530
Range on HMM: 46-120/319.0
VDAKNHSCKPNDYINANYLKLTQINPdFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNN
|  .  . . . |..|.|..  .  |   |||.|..| ..  |||...  .. .||. | .  || ...   |.  
vlqrigdddkdeyldasyvrGyddap.nsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPt

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 468-531 2.2e-08 28.2 In-house 78-139 (301) alignment
Range on Protein: 468-531
Range on HMM: 78-139/301.0
INANYLKlTQINPDfKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNL
| ||... |. .|. ..||||.||..|..||| ...  .|. |. |    | . .| . |    
ihanwip.tsGhph.rfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvk

subfamily_PTPN1_pd Subfamily PTPN1 657-736 2.3e-08 28.1 In-house 199-269 (290) alignment
Range on Protein: 657-736
Range on HMM: 199-269/290.0
ANSSPLLVHCSAGCGRTGVFVTLDFLLSILSPTTNhSNKIDVwnmTQDLIfiivnELRKQRISMVQNLTQYIACYEALLN
 .  | ..||||| ||.| |. .| .|  .  . .  . .|.    . |.     ||||.|. ..|   |    | |.|.
sdvGpavihcsaGiGrsGtfclvdtclvliekkdd.lssvdi...kkvll.....elrkyrlGliqtadqlrfsylaile

subfamily_CG42327_pd Subfamily CG42327 645-738 2.5e-08 28.0 In-house 233-315 (319) alignment
Range on Protein: 645-738
Range on HMM: 233-315/319.0
IDDNNSELHLDTANSSPLLVHCSAGCGRTGVFVTLDFLLSILSpTTNHSnkIDVWNmtqdlifiIVNELRKQRISMVQNLTQYIACYEALLNYF
|. | |       .  || |||| | ||||. .. |. .  |  ....|  .|. .        .|  .|..| | |..  ||   |  | .| 
ingnissrsgtresqGPlvvhcsdGvGrtGlviasdiairsle.eskrs..vdiPq........lvssvrrdrasavltkeqyefiykvlseya

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 458-525 2.9e-08 27.8 In-house 66-131 (305) alignment
Range on Protein: 458-525
Range on HMM: 66-131/305.0
KNHSCKPNDYINANYLKlTQINPDfKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWD
| ..  | .|| |||.  |  ||  ..| |||||  |  ||| .   .||. |. |    |   .|  
klegpwpheyihanyvs.tptnpk.rfictqaplektcadfwymclqdkveaifmlcnllekgakkcl

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 462-525 2.9e-08 27.7 In-house 66-126 (303) alignment
Range on Protein: 462-525
Range on HMM: 66-126/303.0
CKPNDYINANYLKLtqiNPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWD
     || |.||.|   . . | | || ||. |  |||..|  .|||... | .| | .    |
lsdssyihasylel...dsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggd

subfamily_PTPRN_pd Subfamily PTPRN 658-733 3.2e-08 27.6 In-house 223-287 (297) alignment
Range on Protein: 658-733
Range on HMM: 223-287/297.0
NSSPLLVHCSAGCGRTGVFVTLDFLLSILSpttNHSNKIDVwnmtqdliFIIVNELRKQRISMVQNLTQYIACYEA
 |.|..||||.|.|||||.. .|..|. |    .  ..||.           .. || ||  .|.   |.  .. |
rscpivvhcsdGaGrtGvyilidlvlnrll...kGvkeidi........aatlehlrdqrpglvktkdqfefalta

subfamily_CG7180_pd Subfamily CG7180 464-619 3.7e-08 27.4 In-house 69-208 (296) alignment
Range on Protein: 464-619
Range on HMM: 69-208/296.0
PNDYINANYLKltQINPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLrKWDIYWNNLS---YSNHTIKLQNTwENICNIngcVLRVFQV
 .||||| |        . .|| |.||  .|.|.||...  .... .. |    . .  ..  || | |   | .  ... .. ..  |.   . | |..
ksdYinavyvd..sflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqygeifveivee.kqyanl...kirtfkl

KKTapqndnisqdcdlphngdLT----SITMAVSEPFIVYQLQYKNWLD--SCGVDMNDIIKLHK
.|.                  .       .  . |  || ..|.. |    .. .  | .|.| .
tkk..................ivalteqekqvkaetRivklfqlteWeledkvPlstnalielrr

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 458-529 4.4e-08 27.4 In-house 55-122 (285) alignment
Range on Protein: 458-529
Range on HMM: 55-122/285.0
KNHSckpNDYINANYLKLTQINpDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWN
|||     ||| |.....   . .  ||.|| ||| |. |||..|  .|.  .. | .  |  . |  .|. 
knhd...rdyihaswmrmpgkd.qstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyyp

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 462-567 4.6e-08 27.0 In-house 76-181 (310) alignment
Range on Protein: 462-567
Range on HMM: 76-181/310.0
CKPNDYINANYLKLTQINPDFkyIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSYSN--HTIKLQNTWENICNINGCVLRVFQ
 . .||| |||.|   .   |  | .| ||  |. |||..|  .. . |. |    |    |   ||  |  ..    |.. |  |   ... | | |  
sryedyihanyvktnylrstf..icsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtf

VKKTAPQN
|    | .
vpdnvpvd

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 659-739 1.9e-07 25.3 In-house 203-271 (285) alignment
Range on Protein: 659-739
Range on HMM: 203-271/285.0
SSPLLVHCSAGCGRTGVFVTLDFLLSILSptTNhsNKIDvwnmtqdlIFIIVNELRKQRISMVQNLTQYIACYEALLNYFA
  |. |||||| |||  || .|.    .    |   .|.        .. || |.|  |.  ||.  |..  |  |..|| 
ekpicvhcsagvgrtatfvgidyatirim..en..pnie........mldivremramrfqavqshmqflflyvvlmeyfi

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 465-543 2.4e-07 25.1 In-house 35-114 (239) alignment
Range on Protein: 465-543
Range on HMM: 35-114/239.0
NDYINANYLKLTQINPDfKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNL--SYSNHTIKLQNT
.|||||.||.  . .|   |||||  .  .  |||...  ..  ||. |    |   .|   || .    | |  . |..|
sdyinasylrdydgspk.ayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrvtlrkt

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 465-543 2.5e-07 25.1 In-house 36-115 (239) alignment
Range on Protein: 465-543
Range on HMM: 36-115/239.0
NDYINANYLKLTQINPDfKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNL--SYSNHTIKLQNT
.|||||.||.  . .|   |||||  .  .  |||...  ..  ||. |    |   .|   || .    | |  . |..|
sdyinasylrdydgspk.ayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrvtlrkt

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 656-747 4.7e-07 23.7 In-house 197-278 (281) alignment
Range on Protein: 656-747
Range on HMM: 197-278/281.0
TANSSPLLVHCSAGCGRTGVFVTLDFLLSILsptTNHsnkidvwnMTQDLIFIIVNELR-KQRISMVQNLTQYIACYEALLNYFALQKQIKNA
 | |.| ..||||| ||.| .....  |  .    .|        .|   |  ||  ||   | . || | ||.  .. ||..    ||| . 
rarstppvihcsagvgrsgtlmaveialqsi...hsh........ftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgvaykqitee

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 659-735 6.6e-07 23.7 In-house 173-237 (239) alignment
Range on Protein: 659-735
Range on HMM: 173-237/239.0
SSPLLVHCSAGCGRTGVFVTLDFLLSilspTTNHSNKIDVWNmtqdlifiIVNELRKQRISMVQNLTQYIACYEALL
. | ..||||| |||| |. .| .|      ... . .|..|         |. .|..|  |||   ||.  . |.|
arpwvihcsagvgrtgaflvidamlr....qakkqktvdifn........yvkairedrphmvqtseqyvfihlavl

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 656-729 7.7e-07 23.6 In-house 169-230 (237) alignment
Range on Protein: 656-729
Range on HMM: 169-230/237.0
TANSSPLLVHCSAGCGRTGVFVTLDFLLSilspTTNHSNKIDVWNMtqdlifiiVNELRKQRISMVQNLTQYIA
 ..|.| ..||||| ||||.|. .| .|      ..  . .|..|         |  . ..|  ..|   ||. 
vsesgpwiihcsagvgrtgiflvidamlr....qakekkvvdiyny........vysieedrpyiiqtkdqyvf

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 659-735 7.8e-07 23.5 In-house 174-238 (239) alignment
Range on Protein: 659-735
Range on HMM: 174-238/239.0
SSPLLVHCSAGCGRTGVFVTLDFLLSilspTTNHSNKIDVWNmtqdlifiIVNELRKQRISMVQNLTQYIACYEALL
. | ..||||| |||| |. .| .|      ... . .|..|         |. .|..|  |||   ||.  . |.|
arpwvihcsagvgrtgaflvidamlr....qakkqktvdifn........yvkairedrphmvqtseqyvfihlavl

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 641-739 9.2e-07 22.9 In-house 191-277 (312) alignment
Range on Protein: 641-739
Range on HMM: 191-277/312.0
KPDLIDDNNSELHLDTANSSPLLVHCSAGCGRTGVFVTLDFLLSILspttNHSNKIDVWNmtqdlIFIIvneLRKQRISMVQNLTQYIACYEALLNYFA
 ||  |     |     .  |.. ||||| |||| .. .. ... |     |  | .| .     .|..   |||.|   |. . ||. .  ..|... 
mpdscdtalrllsavkkdkkpviahcsagvgrtgtlaliesmiaal....rhprkqnvkd.....sfvl...lrkdrarsvrvfpqyvyalrcvlefly

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 655-739 9.8e-07 22.5 In-house 214-286 (302) alignment
Range on Protein: 655-739
Range on HMM: 214-286/302.0
DTANSSPLLVHCSAGCGRTGVFVTLDFLLSILspTTNHSNKIDVwnmtqdlifiIVNELRKQRISMVQNLTQYIACYEALLNYFA
..  ......    |.|| |.|.||   .. |  ....  .|            ||. .|.|| ..|..|.||.  | ||| |. 
kikadentvivSknGaGRagafltlavavekl..qkgkepnike..........ivksiRsqRpravdslkQyvslyialllyik

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 406-607 1.1e-06 22.9 In-house 41-185 (288) alignment
Range on Protein: 406-607
Range on HMM: 41-185/288.0
IQSFTKNRYSNILPYEHSRVKLPhspkppavseasttetktdksypmcpvdaknhsCKPNDYINANYLKltQINPDFKYIATQAPLPSTMDDFWKVITLN
|.. |..|| |.   . .||||                                    |. ||.|| .     . . . | .|||| .|.. .||..  .
ianptrdryenlprcditrvkls.................................ddpdfyiaanvvs..sakykrrlicaqaPlngtieelWkmlles

KVKVIISLNSDDELNLRKWDIYWNNLSysNHTIKLQNTwenicningcvlrvfqV---KKTApqnDNISQDCDLphngDLTSITMAVSEPFIVYQLQYKN
 |. |. |.   |. ..| . |.       ......                      ||     ..| .   .     |  |.  . |. || .| ...
dveyivmlcellekGkeksaeyfPskl..Gekarigrl................ctvvkkkr...adidklvkv....sllriskegeekvivkilhlle

WLDSC
| | .
Wdddg

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 465-515 1.5e-06 21.9 In-house 76-124 (439) alignment
Range on Protein: 465-515
Range on HMM: 76-124/439.0
NDYINANYLKltQINPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNS
  ||||||.|      |  |||||.|   | ||||...  .|.  |. |  
shyinanyik..Gyyddklyiatqgpkkettddfwrlviekktvtivmltn

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 462-516 1.8e-06 22.1 In-house 54-106 (267) alignment
Range on Protein: 462-516
Range on HMM: 54-106/267.0
CKPNDYINANYLKLTQINpdFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSD
 | ..|||| |..  . .   ..|.|| ||  |. ||..||. .|| ||. |   
tkeeeyinasyvegyktk..nafivtqdplkntitdfltvihdqkvpvivlltkv

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 462-519 2.1e-06 21.5 In-house 119-174 (244) alignment
Range on Protein: 462-519
Range on HMM: 119-174/244.0
CKPNDYINANYLKLtqINPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDEL
.  | |||| ..    .    .|| || ||  |  ||||..   .|.|.. | | .| 
smgntyinasfvgc..lgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 463-520 6.7e-06 20.4 In-house 11-66 (130) alignment
Range on Protein: 463-520
Range on HMM: 11-66/130.0
KPNDYINANYLKLTQINpdFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELN
. |.||||... |..     .|. ||.||  |  ||||..    | |.. | | .| .
qgntyinasfvGllgrt..aeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 658-731 6.9e-06 20.4 In-house 133-196 (198) alignment
Range on Protein: 658-731
Range on HMM: 133-196/198.0
NSSPLLVHCSAGCGRTGVFVTLDFllSILSPTTNHSNKIDvwnmtqdLiFIIVNELRKQRISMVQNLTQYIACY
. .|..|||| | | |||||.||    . |    ..  .|       | | . . ||. |  ..  | .|   |
kdapvivhcsdgqgftgvfvaldi..gvrsheesktsvvd.......l.fevakrlrqarcgiisslqhynfiy

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 658-731 7e-06 20.3 In-house 134-197 (199) alignment
Range on Protein: 658-731
Range on HMM: 134-197/199.0
NSSPLLVHCSAGCGRTGVFVTLDFllSILSPTTNHSNKIDvwnmtqdLiFIIVNELRKQRISMVQNLTQYIACY
. .|..|||| | | |||||.||    . |    ..  .|       | | . . ||. |  ..  | .|   |
kdapvivhcsdgqgftgvfvaldi..gvrsheesktsvvd.......l.fevakrlrqarcgiisslqhynfiy

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 484-530 7.7e-06 19.5 In-house 238-281 (440) alignment
Range on Protein: 484-530
Range on HMM: 238-281/440.0
YIATQAPLPSTMDDFWKVITLNKVKVIISLNsddELNLRKWDIYWNN
.|||| || ||. |||...   ..  || ||   .|| .   |||  
fiatqmpldstvldfwrlvhdyristiimln...qlndktcsiywpv

subfamily_eak_pd Subfamily eak 462-532 8.1e-06 19.4 In-house 75-143 (332) alignment
Range on Protein: 462-532
Range on HMM: 75-143/332.0
CKPNDYINANYLKLTQINPdfKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLS
  .. ||||  ......    ||| | ..  . .  ||...  .|   |. |  | ||.| | | |. . .
lnrlGyinaslaefsevGr..kyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdkt