Gene CDKN3 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily CDKN3
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP006_AA protein Get Run
SpurP006_AA_41-212 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_CDKN3_pd Subfamily CDKN3 23-217 1.7e-118 387.4 In-house 7-201 (202) alignment 
Range on Protein: 23-217
Range on HMM: 7-201/202.0
CSSGFDSSDDDQEPVDKSPFQIDWLDLSEYGIAEKLGISGLPGCRFDDTWRSMESDINGLISQGVEDVFVLCTRGELNKYRVRRLMQEYTTAGLSVHHYP
 .|.|||||..|..|.|||.||||||||...||||||.|.||||.|||..||.|.||..|.||||||||||||||||.|||||||...|..|||.|||||
qtsefdssdeeqievekspiqidwldlsrvniaeklglsalpgckfddvrrsvekdieelksqgvedvfvlctrgelskyrvrrlldlyqqaglivhhyp

FPAGLVPSPANCMKMLEEIRINLNAGTGTLVHCFGGIGRSSLIIACLLLMLDDYMEWKDAIAKVRQLKGSRAIQTVKQYNFVSDFRKMREEYEAT
...||||..|.|.|.|||.||||.|...|||||.||.|||||.||||||.|||..|.||||.|.|.||||||||||||||..|.||...||| ..
iadglvpdiasclkileelrinlkayrktlvhcygglgrsslviaclllylddtiepkdaidklrdlkgsraiqtvkqynylsefrdkleeylss
CDKN3 Cyclin-dependent kinase inhibitor 3 (CDKN3) 24-183 3e-47 151.9 Pfam-A 9-168 (168) alignment 
Range on Protein: 24-183
Range on HMM: 9-168/168.0
SSGFDSSDDDQEPVDKSPFQIDWLDLSEYGIAEKLGISGLPGCRFDDTWRSMESDINGLISQGVEDVFVLCTRGELNKYRVRRLMQEYTTAGLSVHHYPF
.| |||||..    ...| || || ||    .. ||.  ||||.| |  | .. | . | | |..||||.|||||| ||||  |.. |   |.  ||.| 
asefdssdeepveeeqtpiqiswlslsrvncsqflglcalpgckfkdvrrnvqkdteelksygiqdvfvfctrgelskyrvpnlldlyqqygivthhhpi

PAGLVPSPANCMKMLEEIRINLNAGTGTLVHCFGGIGRSSLIIACLLLMLDDYMEWKDAI
. |  |  | |....||.   |.    ||.||.||.||| |. ||||| | | .  ..||
adggtpdiascleimeelatclknyrktlihcygglgrsclvaaclllylsdsispeqai
CDKN3 Cyclin-dependent kinase inhibitor 3 (CDKN3) 24-183 3e-47 151.9 In-house 9-168 (168) alignment 
Range on Protein: 24-183
Range on HMM: 9-168/168.0
SSGFDSSDDDQEPVDKSPFQIDWLDLSEYGIAEKLGISGLPGCRFDDTWRSMESDINGLISQGVEDVFVLCTRGELNKYRVRRLMQEYTTAGLSVHHYPF
.| |||||..    ...| || || ||    .. ||.  ||||.| |  | .. | . | | |..||||.|||||| ||||  |.. |   |.  ||.| 
asefdssdeepveeeqtpiqiswlslsrvncsqflglcalpgckfkdvrrnvqkdteelksygiqdvfvfctrgelskyrvpnlldlyqqygivthhhpi

PAGLVPSPANCMKMLEEIRINLNAGTGTLVHCFGGIGRSSLIIACLLLMLDDYMEWKDAI
. |  |  | |....||.   |.    ||.||.||.||| |. ||||| | | .  ..||
adggtpdiascleimeelatclknyrktlihcygglgrsclvaaclllylsdsispeqai
0046846 (Phosphotyrosine protein) phosphatases II 41-210 7.9e-38 125.3 In-house 2-171 (176) alignment 
Range on Protein: 41-210
Range on HMM: 2-171/176.0
PFQIDWLDLSEYGIAEKLGISGLPGCRFDDTWRSMESDINGLISQGVEDVFVLCTRGELNKYRVRRLMQEYTTAGLSVHHYPFPAGLVPSPANCMKMLEE
......|||. . | ..| ....|.. . ...|......  | ..|.. |. |... ||..... .. .|....|. ..|.|.| . ||. . ....||.
rlrllgldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellef

IRINLNAGTGTLVHCFGGIGRSSLIIACLLLMLDDYMEWKDAIAKVRQLKGSRAIQTVKQYNFVSDFRKM
||  |..|  .||||..||||. ...|..||.|.  . . .|.|.||. .  .|.|| .|| |. .| ..
irealkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefell
0037934 (Phosphotyrosine protein) phosphatases II 45-208 4.6e-25 84.0 In-house 33-238 (243) alignment 
Range on Protein: 45-208
Range on HMM: 33-238/243.0
DWLDLSEYGIAEKLGISGLPGCRfddTWRS-MESDINGLISQGVEDVFVLCTRGELNKYRVRRL----------------------------------MQ
|..... . . ..| ....|      |. . ..|... | ..|.. .  |..  ||... . ..                                   .
dyinanliyvtprliatqgPlpe...tveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldld

EYTTAGLSVHHYPFPAGLVPS-PANCMKMLEEIRI---------NLNAGTGTLVHCFGGIGRSSLIIACLLLMLD-DyMEWKDAIAKVRQLKGSRAIQTV
..|  .  .|..|.| . ||. |......|.|.|          .|. |  .|||| .|.||. ..||..|..|  . . . .|....|. .. .|.|| 
dltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllg.vdleeavkllreqRpgkavqtp

KQYNFVSDFR
 || |. .. 
sqyrflyeal
0043147 (Phosphotyrosine protein) phosphatases II 74-211 3.5e-24 80.9 In-house 32-160 (172) alignment 
Range on Protein: 74-211
Range on HMM: 32-160/172.0
SMESDINGLISQGVEDVFVLCTRgelnkyrvRRLMQEYTTAGLSVHHYPFPAGLVPSPANCMKMLEEIRI--NLNAGTGTLVHCFGGIGRSSLIIACLLL
 ...... | ..|.  .. |...          ... ..  |. ....|.| . ||...  ...|| |.   .|. |  .|||| .|.||. ...|..|.
tladfwrmlkelgithivnltel........lydpellerlgiqylylpwpDhgvpllellleflefidellalspggpvlVHCsaGvgRtgtlvaaylm

MldDYMEWKDAIAKVRQLKgSRAIQTVKQYNFVSDFRKMR
.    . . .|.| ||. . . |.|.  ||.|. .| |..
l..lglsleeavalvrekR.pgavqnpsqyrflyyfekll
0049260 (Phosphotyrosine protein) phosphatases II 74-210 6e-23 76.6 In-house 21-148 (152) alignment 
Range on Protein: 74-210
Range on HMM: 21-148/152.0
SMESDINGLISQGVEDVFVLCTRGELNKYRVRRLMqeyttaglSVHHYPFPAGLVPSPANCMKMLEEIRIN--LNAGTGTLVHCFGGIGRSSLIIACLLL
....... | ..|.  . .|... ||.|. . ...         ..|.|.| . ||. . ....| ..     |. |  .||||..|.||. ...|..|.
tladfwrmlkelgittivmltellelgklkceqyi........qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylm

MldDYMEWKDAIAKVRQLKgSRAIQTVKQYNFVSDFRKM
.    .....|.| ||. . . |...  |. |. .| |.
l..lgvsleeavalvrekR.pgavpnpgqlrflyefekl
PTEN_1 64-213 7.3e-23 76.4 In-house 45-194 (196) alignment 
Range on Protein: 64-213
Range on HMM: 45-194/196.0
PGCRFDDTWRSMESDINGLISQGVEDVFVLCTRGELnkYRVRRLMQEYTTAGLSVHHYPFPAGLVPSPANCMKMLEEIRINLNA---GTGTLVHCFGGIG
.. .. . ......| . | ..|.  |. |. . ||  .....  .|.   |....|.|..   .|| .  .......   | .   |   |||| .|.|
deglyrgslkdvaadldnlkedgitlvvnlseeeel..sgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlg

RSSLIIACLLLMLDDyMEWKDAIAKVRQLKGSRAIQTVKQYNFVSDFRKMREE
|| ...|..|. .   .  ..|.. ||.    .|... .|  ..  |.....|
RsGtvvaayLmykgk.ltadeAlelvrekRppgapnspsqerlleyfaellae
0036282 (Phosphotyrosine protein) phosphatases II 73-210 1e-22 76.1 In-house 27-168 (174) alignment 
Range on Protein: 73-210
Range on HMM: 27-168/174.0
RsmesDINGLISQGVEDVFVLCTRGELNKYRVRRLM----QEYTTAGLSVHHYPFPAGLVPSPANCMKMLEEIRINLNA--GTGTLVHCFGGIGRSSLII
.    ..  | ..|...|. |..  ||..|.. ..     . ..  |. ....|.| . ||. .   .......  |.   |  .|||| .|.||. ...
a....fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvlVHCsaGvgRtGtlv

ACLLLMLDDYMEWKDAIAKVRQLK--GSRAIQTVKQYNFVSDFRKM
|..|..   ..   ||.. ||.|.   ....||  || |. .|.|.
aaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekl
0045098 (Phosphotyrosine protein) phosphatases II 62-208 4.9e-22 74.1 In-house 33-268 (278) alignment 
Range on Protein: 62-208
Range on HMM: 33-268/278.0
GLPGCRFDDTWRS-------------------------------MESDINGLISQGVEDVFVLCTRGELN------------------------------
.|. .|. | .                                 ...... | ..|.. .  |..  ||.                              
nldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevld

-----KYRVRRL---MQEYTTAGLSVHHY-PFPAGLVPSPA---NCMKMLEEIRINLN--------------AGTGTLVHCFGGIGRSSLIIACLLLMLD
     ...|. |    ......|. ..|| |.| . |||        ..||.||  |.               |. .||||  |.||.  ..|. |..  
dytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlel

--DYMEWKDAIAKVRQLKGSRAIQTVKQYNFVSDFR
  . . . .|....|. .. .|.|.  ||.|. .| 
leggvdlleavkelrsqRpglavqnleqyrflyefl
0044763 (Phosphotyrosine protein) phosphatases II 56-211 5.6e-21 70.4 In-house 28-170 (178) alignment 
Range on Protein: 56-211
Range on HMM: 28-170/178.0
EKLGISGLPGcrfddtwrsmESDINGLISQGVEDVFVLCTRGELNkyRVRRLMQEYTTAGLSVHHYPFPAGLVPS-PANCMKMLEEIRINL-NAGTGTLV
. | ...||           ..|.. |  .|.  .  |..  ||.  ..  . . .. ||. ..|.|.| . ||. .. .....| |.  | . |  .||
pglylgslpp..........addlellkelgithivnlteelelg..flkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlV

HCFGGIGRSSLIIACLLLMLDDYmEWKDAIAKVRQLKGsrAIQTVKQYNFVSDFRKMR
||  |.||| ...|. |..  ..  . .||. ||. .   ....  |.... .| .. 
HCsaGvgRsgtlvaaylmkklgl.sleeaielvrerRp..ivpnpgqlrqLyefelrl
0042113 (Phosphotyrosine protein) phosphatases II 56-207 6e-21 70.4 In-house 52-238 (245) alignment 
Range on Protein: 56-207
Range on HMM: 52-238/245.0
EKLGISGLPGCRfddtwrSMESDINGLISQGVEDVFVLCTRGELNKY-----------------------------------RVRRLMQEYTTAGLSVHH
.|. ... |         . |  .. | ..|.. .. |..  ||..                                    .| .|   ..  .. .|.
pkfiatqgPlpe......tvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhy

YPFPAGLVPS-PANCMKMLEEIRINLN--AGTGTLVHCFGGIGRSSLIIACLLLM----LDDYMEWKDAIAKVRQLKgSRAIQTVKQYNFVSDF
.|.| . ||. ..   ..||..|  |.  ... .|||| .|.||. ..||..|..        . . .|....|. . . |.||  || |. ..
lpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqR.pgavqtpsqyrflyea
0045450 (Phosphotyrosine protein) phosphatases II 82-207 1e-20 70.1 In-house 127-299 (307) alignment 
Range on Protein: 82-207
Range on HMM: 127-299/307.0
LISQGVEDVFVLCTRGELNK-------------------------------YRVRRLMQE---YTTAGLSVHHYPF---PAGLVP-SPANCMKMLEEIRI
|  |||. .  |..  ||..                               | ||.|  .   .|  .. |.|...   | . || |.. . ...||.| 
lweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrk

NLN---AGTGTLVHCFGGIGRSSLIIACLLLMLDD-------YMEWKDAIAKVRQLKgSRAIQTVKQYNFVSDF
 |.    |. .|||| .|.||.  .||..|..          .. . .|....|. . . |.|.  || |. ..
aleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqR.pgavqnpeqyrflyea
0041856 (Phosphotyrosine protein) phosphatases II 57-213 2.8e-20 68.1 In-house 25-172 (182) alignment 
Range on Protein: 57-213
Range on HMM: 25-172/182.0
KLGISGLPGCRFDDTWRSM----ESDINGLISQGVEDVFVLCtrgelnkyRVRRLMQEYTTAGLSVHHYPFPAGLVPSpanCMKMLEEIRINLNAGTGTL
.| ...||..||  |.. .    ..... | ..|.  .  |.         ..   .... .|. ....|.| . ||.     ..|. |.. |. |  .|
nlylgslpatrfiatqgpllstvadflrmlkelgittivnlt........eelywpellerlgiqylylpwpDhgvpd...ldelldfieevleeggpvl

VHCFGGIGRSSLIIACLLLMLDDyMEWKDAIAKVRQLKgSRAIQTVKQYNFVSDFRKMREE
||| .|.||.  ..|. |..  . . . .|.. ||. . . ...|  || |. ..  .. .
VHCsaGvgRtgtlvaaylmkklg.vsleeavklvrsrR.pgmvitpnqyfflqlallelll
0048179 (Phosphotyrosine protein) phosphatases II 77-209 1.3e-19 65.8 In-house 20-142 (144) alignment 
Range on Protein: 77-209
Range on HMM: 20-142/144.0
SDINGLISQGVEDVFVLCTRGELNKYRVRrlmqeyttaGLSVHHYPFPAGLVPSP-ANCMKMLEEIRINLNAGTGTLVHCFGGIGRSSLIIACLLLMLDD
.|.  | ..|.  |. |..  | . . .          |. ..|.|.|   ||.  . . ..|| |.  |. |  .|||| .|.||. ...|. |... .
ldlellkklgittvinlteeyepeflere.........giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmkklg

yMEWKDAIAKVRQLKgSRAIQTVKQYNFVSDFRK
 . ...|.| ||.   . |...  |..|. ...|
.lsleealalvrsrr.pgavpnpgqlrfLleyek
0039614 (Phosphotyrosine protein) phosphatases II 82-207 1.9e-19 65.7 In-house 121-284 (297) alignment 
Range on Protein: 82-207
Range on HMM: 121-284/297.0
LISQGVEDVFVLCTRGELNK----------------------------YRVRRLMQEYttAGLS-----VHHYPFPAGLVP-SPANCMKMLEEIRINLN-
.  |||. .  |..  ||..                            | || |  ..   | |     ......| . || |.. ....||..|  |. 
vweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealae

--AGTGTLVHCFGGIGRSSLIIACLLLM----LDDYMEWKDAIAKVRQLKgSRAIQTVKQYNFVSDF
   |. .|||| .|.||.  .||..|..        . ...|....|. . . |.||  || |. |.
lpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqR.pgavqtpsqyrflyda
0048076 (Phosphotyrosine protein) phosphatases II 82-209 2.3e-19 64.9 In-house 25-140 (145) alignment 
Range on Protein: 82-209
Range on HMM: 25-140/145.0
LISQGVEDVFVLctrgelnkyrvRRLMQEYTTAGLSVHHYPFPAGLVPSP-ANCMKMLEEIRINLNAGTGTLVHCFGGIGRSSLIIACLLLMLDDyMEWK
| . |.  |. |            .  . ..  |. ....|.|   ||.  .  ...|| |.  |..|  .||||  |.||. ...|. |..| . . . 
lkdlgittvlnl...........tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmlllg.vsle

DAIAKVRQLKgSRAIQTVKQYNFVSDFRK
.|...||.   . |.... |..|. .| .
ealelvrsqr.pgavpnpgqlrflyefel
0049772 (Phosphotyrosine protein) phosphatases II 94-212 2.4e-19 65.7 In-house 167-280 (314) alignment 
Range on Protein: 94-212
Range on HMM: 167-280/314.0
CtrgelnkyRVRRLMQEYTTAGLSVHHYPFPAGLVPSPANCMKMLEEIRINlNAGTGTLVHCFGGIGRSS-LIIACLLLMLDDYmEWKDAIAKVRQLKG-
.        ..    . .. .|. ....|.| | .|...   ..|| |. . ..|. .|||| .|.||.  ...|..|..| ..  ...|.. ||.    
k........eelydpelferlgikylripvpDgsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRpi

---SRAIQTVKQYNFVSDFRKMRE
    ..|.. .|| |. ...... 
npnpgfieqleqyefilealleyl
0051429 (Phosphotyrosine protein) phosphatases II 76-209 2.9e-19 65.2 In-house 35-222 (272) alignment 
Range on Protein: 76-209
Range on HMM: 35-222/272.0
ESDINGLISQGVEDVFVLCTRGELNKYRVRRLMqeyttAGLSVHHYPFPAGLVPSP--------------------------------------------
. |.  | ..|.  .. |..  |.... . |.      .|. ..|.|..   .|..                                            
aadfwrlkelgiktivdLrseeErgrlkcdryw.....pgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytd

--------ANCMKMLEEIRInlnaGTGTLVHCFGGIGRSSLIIACLLLMLDDYME------------WKDAIAKVRQLKgSRAIQTVKQYNFVSDFRK
          . ..||...     |   ||||..|..|. ...|.|||.|.  .|            . .|....|.     |.||  || |. .. .
wpdhgvpqeallellellld....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqr.pgavqteeqylflyeall
0040439 (Phosphotyrosine protein) phosphatases II 74-207 9.6e-19 63.4 In-house 66-241 (249) alignment 
Range on Protein: 74-207
Range on HMM: 66-241/249.0
SMESDINGLISQGVEDVFVLCTRGELN------------------------------KYRVRRLMQE--YTTAGLSVHHYPF----PAGLVPSPANCMKM
..|.... |  .|.. .  |..  ||.                              .| || |. .  |.   . |.|...      |. ||.. ....
tvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldf

LEEIRINLN---AGTGTLVHCFGGIGRSSLIIACLLLM----LDDYMEWKDAIAKVRQLKgSRAIQTVKQYNFVSDF
.|..|  |.    |. .|||| .|.||. ..||..|..        .  ..|....|. . . |.|.  || |. ..
ieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqR.pgavqnpeqyrflyea
0040438 (Phosphotyrosine protein) phosphatases II 82-207 3.2e-18 61.5 In-house 106-271 (317) alignment 
Range on Protein: 82-207
Range on HMM: 106-271/317.0
LISQGVEDVFVLCTRGELN------------------------------KYRVRRLMQE----YTTAGLSVHHYPF-PAGLVP-SPANCMKMLEEIRINL
.  |||. .  |..  ||.                               . .|.|. |     ..  . ..||.. | . || ||  . ..||..| .|
vweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreal

NA-GTGTLVHCFGGIGRSSLIIACLLLM----LDDYMEWKDAIAKVRQLKgSRAIQTVKQYNFVSDF
.  |. .|||| .|.||.  .||..|..        . ...|....|. . . |.||  || |. |.
edpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqR.pgavqtpeqyrflyda
0051082 (Phosphotyrosine protein) phosphatases II 61-204 8.6e-18 59.8 In-house 18-145 (151) alignment 
Range on Protein: 61-204
Range on HMM: 18-145/151.0
SGLPgcrfddtwrsMESDINGLISQGVEDVFVLCTRGELNkyrvrRLMQEYTTAGLSVHHYPFPAGLVPS-PANCMKMLEEIRINLNA-GTGTLVHCFGG
|| |          .. ... | ..|.  .. |..  | .      . . .. .|. |.|.|..   .|. | .   .|| ... |.  .  .|||| .|
sggp..........ladflellkelgiktivnlrseeerg.....ycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaG

IGRSSLIIACLLLMLDdyMEWKDAIAKVRQLKGsRAIQTVKQYNFV
.||. ...|..|..|.  . . .|.. .|.  .  ..|.  |. |.
kgRTGtlvalylmllg..vsleealeeyrlkrp.gvvqpnqqflfq
0043336 (Phosphotyrosine protein) phosphatases II 82-207 1.2e-17 59.7 In-house 108-272 (278) alignment 
Range on Protein: 82-207
Range on HMM: 108-272/278.0
LISQGVEDVFVLCTRGELNK-----------------------------YRVRRL-----MQEYTTAGLSVHHYPFPAGLVP-SPANCMKMLEEIRINLN
.  .||. . .|..  ||..                             | || |        ..  .. .|....| . || |..  ...|...|  |.
vwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale

-AGTGTLVHCFGGIGRSSLIIACLLLM----LDDYMEWKDAIAKVRQLKgSRAIQTVKQYNFVSDF
  .. .|||| .|.||. ..||..||.        .   .|....|. .   |.||  || |. ..
dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqR.pgavqtpsqyrflyea
0047943 (Phosphotyrosine protein) phosphatases II 82-204 3.8e-17 58.1 In-house 97-264 (273) alignment 
Range on Protein: 82-204
Range on HMM: 97-264/273.0
LISQGVEDVFVLCTRGELNK---------------------------------YRVRRLMQEY-----TTAGLSVHHYPFPAGLVP-SPANCMKMLEEIR
.  |.|. . .|..  ||..                                 | || |. ..     .     .|....|   || |.. .....|..|
vweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvr

INLN---AGTGTLVHCFGGIGRSSLIIACLLLM----LDDYMEWKDAIAKVRQLKGSrAIQTVKQYNFV
  |.    .. ..||| .|.||.  .||..||.        .  ..|....|. .   ..||. || |.
kalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpg.mvqtpeqyrfl
0046845 (Phosphotyrosine protein) phosphatases II 84-206 9.9e-17 56.7 In-house 99-268 (284) alignment 
Range on Protein: 84-206
Range on HMM: 99-268/284.0
SQGVEDVFVLCTRGELNK-------------------------------YRVRRLMQEY---TTAGLSVHHYPF---PAGLVP-SPANCMKMLEEIRINL
 |.|. . .|..  | ..                               | ||.|. ..   |   . |.|. .   |   || ||.. ...|...|  |
eqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrell

NA---GTGTLVHCFGGIGRSSLIIACLLLMLD----D---YMEWKDAIAKVRQLKGSrAIQTVKQYNFVSD
..   |  ..||| .|.||.  .||. ||.      .    .   .|....|. .   ..||. || || .
enlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpg.mvqtleqyrfvye
0051299 (Phosphotyrosine protein) phosphatases II 84-204 2.8e-16 55.3 In-house 114-278 (288) alignment 
Range on Protein: 84-204
Range on HMM: 114-278/288.0
SQGVEDVFVLCTRGELN------------------------------KYRVRRLMQE------YTTAGLSVHHYPF----PAGLVPSPANCMKMLEEIRI
 |.|. . .|..  ||.                              .| || |. .      ..   . |.|. .      |  .||  ....|...| 
eqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrk

NLNA-GTGTLVHCFGGIGRSSLIIACLLLM----LDDYMEWKDAIAKVRQLKGSrAIQTVKQYNFV
 |.. |  ..|||  |.||.  .||..||.        ... .|....|. .   ..||. || ||
alasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpg.mvqtpeqyrfv
0038934 (Phosphotyrosine protein) phosphatases II 78-207 5.9e-16 54.1 In-house 34-172 (194) alignment 
Range on Protein: 78-207
Range on HMM: 34-172/194.0
DINGLISQGVEDVFVLCTRGELNKYRVRRLM--------QEYTTAGLSVHHYPFPA-GLVPSPANCMKMLEEIRINLNA--GTGTLVHCFGGIGRSSLII
 |..|   ..||.. ...    . . | .|         .|.. ||. ....|||  | ||| .. .. |. .   ||.  |   .||| .|.||. ...
yieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlv

ACLLLMLDDyMEWKDAIAKVRQLKGSRaIQTVKQYNFVSDF
|. |..  . |  ..||| .|. ...  |....... .  .
aaYLiyrlg.msaeeAialfrekRpga.ipnqdyleallkr
0050432 (Phosphotyrosine protein) phosphatases II 85-204 2.3e-15 52.2 In-house 131-291 (308) alignment 
Range on Protein: 85-204
Range on HMM: 131-291/308.0
QGVEDVFVLCTRGELNK---------------------------------YRVRRLMQEY--TTAGLSVHHYPF---PAGLVP-SPANCMKMLEEIRINL
|.|. . .|..  | ..                                 | || |. ..  .   . |.|. .   | . || ||. ....||..|  |
qnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl

nAGTGTLVHCFGGIGRSSLIIACLLL----MLDDYMEWKDAIAKVRQLKGSrAIQTVKQYNFV
  |  ..|||  |.||.  .||..||      .  . . .|..|.|. .   ..||. || |.
.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpg.mvqtpeqylfl
0036941 (Phosphotyrosine protein) phosphatases II 84-207 9.6e-15 50.1 In-house 100-272 (297) alignment 
Range on Protein: 84-207
Range on HMM: 100-272/297.0
SQGVEDVFVLCTRGE----------------------------------LNKYRVRRLMQEY--TTAGLSVHHYPFP---A-GLVPSPANCMKMLEEIRI
 |.|. . .|..  |                                  |. | .| |  ..  .   . |.|. ..     |. .||| .....|..| 
eqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrk

NLN---AGTGTLVHCFGGIGRSSLIIACLLLM-------LDDYMEWKDAIAKVRQLKGSrAIQTVKQYNFVSDF
 |.    |. .|||| .|.|||  .||. |..           .  ..|. |.|. .   |.||. || |. ..
vlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpg.avqtleqyrflyea
subfamily_PTPDC1_pd Subfamily PTPDC1 108-210 5.6e-13 43.7 In-house 75-174 (182) alignment 
Range on Protein: 108-210
Range on HMM: 75-174/182.0
MQEYTTAGLSVHHYPFPAGLVPSPANCMKMLEEIRINLNAGtGTLVHCFGGIGRSSLIIACLLLMLDDyMEWKDAIAKVRQlKGSRAIQTVKQYNFVSDF
..... .|. |. ....   |.|  . . .   .   |. |  . |||  | ||  ..||| |.  .. .. ..|| .||. | ...||| .| ..|..|
lealmeqgiyvynfgwkDygvasleriLdivkvvafalqeg.kvavhChaGlGrtGvliacylvyakr.ltaekaiklvrs.krpksiqtreqvelvkef

RKM
...
alf
PTPc_DSPc_SM00012 119-205 5e-11 38.1 In-house 6-100 (105) alignment 
Range on Protein: 119-205
Range on HMM: 6-100/105.0
HHYPFPAGLVPS-PANCMKMLEEIRINLNA---GTGTLVHCFGGIGRSSLIIACLLLMLDD-----YMEWKDAIAKVRQLKgSRAIQTVKQYNFVS
|..  |   ||. . . ...|.... | |.   .. ..|||. |.||.  ..|  .|. .       ..... . ..|. . ....||  || |. 
hytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqR.pgmvqteeqylfly
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 95-206 1e-09 32.9 In-house 154-273 (288) alignment 
Range on Protein: 95-206
Range on HMM: 154-273/288.0
TRGELNKYRVRRLMQEYTTAGLSVHHYPFPA---GLVP-SPANCMKMLEEIRINLNAGTGT-LVHCFGGIGRSSLIIACLLLM--L--DDYMEWKDAIAK
   ||... .|.|. | ..  | ...| . |     || | |. ...|. . .. .| ||  .|||  |.||.   ||   |.  .  .||..  ...||
eskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvak

VRQLKgSRAIQTVKQYNFVSD
.|. .    .||.||| |. .
lRkqR.allvqtlkqYefiye
subfamily_PRL_pd Subfamily PRL 110-210 2e-09 31.7 In-house 50-148 (151) alignment 
Range on Protein: 110-210
Range on HMM: 50-148/151.0
EYTTAGLSVHHYPFPAGLVPSPANCMKMLEEIRINLN--AGTGTLVHCFGGIGRSSLIIACLLlmLDDYMEWKDAIAKVRQlKGSRAIQtVKQYNFVSDF
.  ..|..|. ..|  | ||. .   . || .. . .  ...   |||  |.||. ...|  |  ... |. .||.  .|. |   ||   || .|. ..
klekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalal..ieaGmkyedavefire.krrgain.skqlkfleky

RKM
.. 
kak
subfamily_PTPMT1_pd Subfamily PTPMT1 75-209 2.2e-09 32.0 In-house 34-166 (171) alignment 
Range on Protein: 75-209
Range on HMM: 34-166/171.0
MESDINGLI-SQGVEDVFVLCTRGELNKYRvrRLMQEYTTAGLSVHHYPFPAGL-VPSPANCMKMLEEIRINLNAGTGTLVHCFGGIGRSSLIIACLLlM
..|.|. || .. |. |  |.   ||. .     ..|..  |.   ... .     |. ..  | .| |.   . |    ||| .| |||. ..|| | |
frslikeLiekenvkavvslneeyelkala..nsteewkklgveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacyl.m

LDDYMEWKDAIAKVRQLKGSRAIQTvKQYNFVSDFRK
. . .. ..|.  ... .    ... ||.. .. ...
kkeklspeeAlkalkkkRkiirlak.kqwkalqeyee
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 78-205 7.2e-09 30.0 In-house 124-257 (270) alignment 
Range on Protein: 78-205
Range on HMM: 124-257/270.0
DINGLISQGVEDVFVLCTRGELN-KYRVRRLMqEYTTAGLSVHHYPFPAGLVPSPANCMKMLEEI---RINLNAGTGTLVHCFGGIGRSSLIIA----CL
.|. | .. . . . . || .|. |   |||.  .       |  |  .. . |. . .|||...   . .|. .. .||||  |.||. ..||    . 
kikvlalseekeegyiltrlrleekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavr

LLMLDDYMEWKDAIAKVRQLKGsRAIQTVKQYNFVS
||  .  ..    |...|. .    .|...||.|. 
lLeetkkvdvlaiieelRkdRm.alvqhpeqyefly
subfamily_DSP23_pd Subfamily DSP23 133-208 7.3e-09 30.4 In-house 72-142 (148) alignment 
Range on Protein: 133-208
Range on HMM: 72-142/148.0
NCMKMLEEIRinlNAGTGTLVHCFGGIGRSSLIIACLLLMLdDYMEWKDAIAKVRQLKGSrAIQTVKQYNFVSDFR
. ....||     . .    |||  | ||.  ..|| |.     .   .|||.||.|.   ...||.| . | |. 
efvrvveeae...ekneavsvhcllgrgrtgtmlacylvke.rklaaaeaiaevrrlrpg.svetveqeklvrdye
Y_phosphatase Protein-tyrosine phosphatase 117-206 7.5e-09 30.7 Pfam-A 137-231 (235) alignment 
Range on Protein: 117-206
Range on HMM: 137-231/235.0
SVHHYPFPAGLVP-SPANCMKMLEEIRINL-NAGTGTLVHCFGGIGRSSLIIACL--LLMLDD--YMEWKDAIAKVRQLKgSRAIQTVKQYNFVSD
 .|.   |   || || . ........ .  .  . ..|||  |.||.  ..|    | .|..   .. .... ..|. .   ..|...|| |. .
qlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqR.pgmvqsleqYiflyk
Y_phosphatase Protein-tyrosine phosphatase 117-206 7.5e-09 30.7 In-house 137-231 (235) alignment 
Range on Protein: 117-206
Range on HMM: 137-231/235.0
SVHHYPFPAGLVP-SPANCMKMLEEIRINL-NAGTGTLVHCFGGIGRSSLIIACL--LLMLDD--YMEWKDAIAKVRQLKgSRAIQTVKQYNFVSD
 .|.   |   || || . ........ .  .  . ..|||  |.||.  ..|    | .|..   .. .... ..|. .   ..|...|| |. .
qlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqR.pgmvqsleqYiflyk
subfamily_PTPRB_pd Subfamily PTPRB 96-205 5.8e-08 27.1 In-house 159-278 (293) alignment 
Range on Protein: 96-205
Range on HMM: 159-278/293.0
RGELNKYRVRRLMQEYTTAGLSVHHYPFPA---GLVPSPAN-CMKMLEEIRINL---NAGTGTLVHCFGGIGRSSLIIACLLLMLD-DYMEWKDAIAKVR
  ||... .| |. | ...  .|..| | .     ||. ..  .......| ..   .. . ..|||  |.||.   ||   |. . .  .. | .. | 
eeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgiva

QLKGSR--AIQTVKQYNFVS
.|. .|   .||.||| |. 
elReeRnllvqtekqYifih
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 98-205 8e-08 26.7 In-house 143-261 (274) alignment 
Range on Protein: 98-205
Range on HMM: 143-261/274.0
ELNKYRVRRLMQEYTTAGLSVHHYPFPA---GLVPSPA-NCMKMLEEIR---INLNAG-TGTLVHCFGGIGRSSLIIACLLLML----DDYMEWKDAIAK
| |.|.||.|. .|..   ||.|| ...     .|  | . .....|..    . ||  . ..|||  ||||    || .. .     .  ..    ...
erndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcn

VRQLKGSrAIQTVKQYNFVS
.|. .|   .|| .||... 
lrldrGG.mvqtseqyelih
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 123-214 8.9e-08 26.6 In-house 196-288 (325) alignment 
Range on Protein: 123-214
Range on HMM: 196-288/325.0
FPAGLVPSPANCMKMLEEIRINLNAGTGTLVHCFGGIGRSSLIIAcLLLMLDDYMEW--KDAIAKVRQLKGSR--AIQTVKQYNFVsdFRKMREEY
.|| |..      .. | .. | .| |  ||||  |.||.   |. |  .|.  .|    |    |..|.  |   ..|| || ..  .  . | |
rpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfis.lysalakvieesrvdifgfvkklrkdrpsmvetvdqyili..yealveay
subfamily_DSP15_pd Subfamily DSP15 134-190 1.1e-07 26.0 In-house 67-119 (151) alignment 
Range on Protein: 134-190
Range on HMM: 67-119/151.0
CMKMLEEIRINlnaGTGTLVHCFGGIGRSSLIIACLLLMLDDyMEWKDAIAKVRQLK
..... . |..   . . ||||. |. ||  ...  |.   . ..|.||.  ... .
svefihkcRlk...eenvlvhClaGvsRsvtlvvaYlmtvte.lnwrdalevikaaR
subfamily_PTPN3_pd Subfamily PTPN3 124-206 1.5e-07 25.7 In-house 182-269 (280) alignment 
Range on Protein: 124-206
Range on HMM: 182-269/280.0
PAGLVPS-PANCMKMLEEIRINL-NAGTGTLVHCFGGIGRSSLIIAC-LLLMLDDYMEWKDAIAKVRQLKGSRA--IQTVKQYNFVSD
|   ||. .|. ....|..|     . . ..||| .||||. ..|.  . |.| .  |    .. ||...  ||  .||..||.|| .
pdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCe
subfamily_PTEN_pd Subfamily PTEN 47-211 2.5e-07 25.9 In-house 18-179 (184) alignment 
Range on Protein: 47-211
Range on HMM: 18-179/184.0
LDLSEYGIAEKLGISGLPGCRFDDTWRSMESDINGLISQGVEDVFVLCTRGELNKYRVRRLmqeyttaGLSVHHYPFPAGLVPSPANCMKMLEEIRINLN
|||    | |.. . | |  . . ..|   .|.  .. .  .| . .      .||  ...          |..|||     |.     ...|.|.  |.
ldLDlsyiteniiamgyPaeklealyRnsledvvkflekkhkdhykiynlrserkydskkf.......dgrvavypfdDhnppplelleeivediekwle

AGTG--TLVHCFGGIGRSSLIIACLLLMLDDYMEWKDAIAKVRQL--KGSRAIQTVKQYNFVSDFRKMR
. .     |||  | ||. ..|...||    . . ..|..   .   | .....   |  .|. ..|. 
edkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknkkgvtiPsqrRYveYyekll
DSPc Dual specificity phosphatase, catalytic domain 145-192 2.6e-07 25.6 Pfam-A 70-115 (133) alignment 
Range on Protein: 145-192
Range on HMM: 70-115/133.0
LNAGTGTLVHCFGGIGRSSLIIACLLlMLDDYMEWKDAIAKVRQLKgS
 . |   ||||  || ||  .|.. | |  . .. ..|.. |.. . |
eqkgkkvlVHCqaGisRSatliiaYl.mktknlslneAyefvkerr.s
DSPc Dual specificity phosphatase, catalytic domain 145-192 2.6e-07 25.6 In-house 70-115 (133) alignment 
Range on Protein: 145-192
Range on HMM: 70-115/133.0
LNAGTGTLVHCFGGIGRSSLIIACLLlMLDDYMEWKDAIAKVRQLKgS
 . |   ||||  || ||  .|.. | |  . .. ..|.. |.. . |
eqkgkkvlVHCqaGisRSatliiaYl.mktknlslneAyefvkerr.s
subfamily_PTPN13_pd Subfamily PTPN13 123-204 2.8e-07 25.1 In-house 176-261 (273) alignment 
Range on Protein: 123-204
Range on HMM: 176-261/273.0
FPAGLVPS-PANCMKMLEEIRINLNAGTGTLVHCFGGIGRSSLIIACL----LLMLDDYMEWKDAIAKVRQLKGsRAIQTVKQYNFV
.|   ||| .|. .... |.|   .  .  .|||  |||||  .|.      |.  |  .. |. . |.|. .    .|| .|| ||
wPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrq.gvvqtkdqyifv
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 134-207 3.2e-07 24.5 In-house 214-290 (297) alignment 
Range on Protein: 134-207
Range on HMM: 214-290/297.0
CMKMLEEIRINLNAGTGTLVHCFGGIGRSSLIIACLLLM-LDDYMEWKDAIAKVRQLKGSR--AIQTVKQYNFVSDF
 .  || .| .    . .||||  |.||| ... .  ..         |. | ...|.  |   .||..|.... |.
vflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellyda
PTPc_motif_SM00404 137-193 3.3e-07 25.3 In-house 69-122 (140) alignment 
Range on Protein: 137-193
Range on HMM: 69-122/140.0
MLEEIRINLNAGTGTLVHCFGGIGRSSLIIACLlLMLDDYMEWKDAIAKVRQLKgsR
.|. |.   . |.  ||||. |. ||  .|..  ||  . .....|.  |.. .   
vldfienaekkggkvlVHCqaGvSRSatliiaY.lmryrqlslaeayefvkerR..p
DSPc_SM00195 111-205 7.7e-07 24.1 In-house 156-255 (263) alignment 
Range on Protein: 111-205
Range on HMM: 156-255/263.0
YTTAGLSVHHYPFPAGLVP-SPANCMKMLEEIRINLNA-GTGTLVHCFGGIGRSSLIIACLLLML--DDY--MEWKDAIAKVRQLKGSrAIQTVKQYNFV
 |.    ...   |   || |. .....|....   .   . ..|||  |.||.  ...  ...   ...  .. .. . ..|. . . ..|| .|| |.
etrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpg.mvqtleqYlfi

S
 
y
PTPc_SM00194 111-205 7.7e-07 24.1 In-house 156-255 (263) alignment 
Range on Protein: 111-205
Range on HMM: 156-255/263.0
YTTAGLSVHHYPFPAGLVP-SPANCMKMLEEIRINLNA-GTGTLVHCFGGIGRSSLIIACLLLML--DDY--MEWKDAIAKVRQLKGSrAIQTVKQYNFV
 |.    ...   |   || |. .....|....   .   . ..|||  |.||.  ...  ...   ...  .. .. . ..|. . . ..|| .|| |.
etrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpg.mvqtleqYlfi

S
 
y
subfamily_Ptp69D_pd Subfamily Ptp69D 127-204 1.1e-06 23.0 In-house 196-278 (307) alignment 
Range on Protein: 127-204
Range on HMM: 196-278/307.0
LVPSP-ANCMKMLEEI-RINLNAGTGTLVHCFGGIGRSSLIIACLLLMLDDYMEWK-DAIAKVRQLKGSRA--IQTVKQYNFV
 ||      .|..|..  .. .  .  .|||  | |||....|  .|.     | | | .. |..|.  |   .|  .|| |.
kvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvfl
subfamily_PTPN6_pd Subfamily PTPN6 98-205 1.5e-06 22.4 In-house 165-290 (306) alignment 
Range on Protein: 98-205
Range on HMM: 165-290/306.0
ELNKYRVRRLMQ---EYTTAGLSVHHYPF---PAGLVPSPANCM-KMLEEIRINLNAGT-----GTLVHCFGGIGRSSL--IIACLLLM-----LDDYME
.|..| .|.|.    .  .   .|..| |   |   ||.  ... ..||... . .  .      ..|||  ||||     .| .|| .     ||  ..
sladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadid

WKDAIAKVRQLKgSRAIQTVKQYNFVS
 .... .||. . |  .|| .||.|| 
iqklvksvreqr.sglvqteqqykfvy
subfamily_CDC14_pd Subfamily CDC14 109-200 1.5e-06 22.3 In-house 227-314 (328) alignment 
Range on Protein: 109-200
Range on HMM: 227-314/328.0
QEYTTAGLSVHHYPFPAGLVPSPANCMKMleeIRINLNAGTGTLVHCFGGIGRSSLIIACLLlMLDDYMEWKDAIAKVRQLKGSRAIQTVKQ
...| ||.  .   |  | .|| |   |.   ..|  .|  .  |||  |.||   .||| | | .  .  ..||| .|  .    |   ..
kkftdaGfdhkDlffiDGstPsdaivkkf...leiaekaeGaiavhCkaGLGrtGtLiacyl.mkhyrftaaeaiawlricrPGsvigpqqk
subfamily_PTPN1_pd Subfamily PTPN1 100-204 2e-06 21.7 In-house 144-263 (290) alignment 
Range on Protein: 100-204
Range on HMM: 144-263/290.0
NKYRVRRLMQEY--T--TAGLSVHHY-PFPAGLVP-SPANCMKMLEEIRI--NLNAGTG-TLVHCFGGIGRSSL--IIACLLLMLDDYM-----EWKDAI
..|.|| |  |   |  |  .. .||  .|   || |||. .|.| ..|    |.   | ...||  |||||    .. ..|. ....      . |. .
syytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvl

AKVRQLKGSrAIQTVKQYNFV
 ..|. .    ||| .| .| 
lelrkyrlG.liqtadqlrfs
subfamily_PTPRK_pd Subfamily PTPRK 119-206 2.9e-06 21.3 In-house 179-271 (314) alignment 
Range on Protein: 119-206
Range on HMM: 179-271/314.0
HHYPFPAGLVPSPAN-CMKMLEEIRINLNAGTG-TLVHCFGGIGRSSLIIACLL-LMLDDYMEWKDAIAKVRQLKGSRA--IQTVKQYNFVSD
..  .|.  ||  |.  .|.. ..    . . | ..|||  | ||.   ||.   | . .  .  |    |..|. ..   ..| .||.|. |
qflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiyd
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 125-206 3.1e-06 21.6 In-house 191-277 (305) alignment 
Range on Protein: 125-206
Range on HMM: 191-277/305.0
AGLVPSPANCMKMLEEIRINLNAGTG--TLVHCFGGIGRSSLIIaCLLLMLDDYMEW--KDAIAKVRQLKGSR--AIQTVKQYNFVSD
 | . ...  ........ . . . |   ||||  |.||.   | .. ..|.   .    |    ..||. .|  ..|| .||.|. |
hGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfi.avdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhd
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 131-205 4.3e-06 21.0 In-house 189-269 (281) alignment 
Range on Protein: 131-205
Range on HMM: 189-269/281.0
PANCMKMLEEI-RIN-LNAGTGTLVHCFGGIGRSSLIIAC--LLLMLDDYMEWKDAIAKVRQLKGSRA--IQTVKQYNFVS
... ..  .|. ...  .  .  ..||  |.||.   ||   |.  ... .|  |  | |..|. .|   .||| ||.|| 
tkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvy
subfamily_DSP12_pd Subfamily DSP12 145-192 7.4e-06 20.4 In-house 79-125 (155) alignment 
Range on Protein: 145-192
Range on HMM: 79-125/155.0
LNAGTGTLVHCFGGIGRSSLIIACLlLMLDDYMEWKDAIAKVRQLKGS
|. .   ||||. |. ||. |..   ||  . .. ..|. .|.. | .
leeegavlvHCqagvSRSvtiviAY.lmkkeklslekAlklvkekkpe