Gene DSP10 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP10
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP009_AA protein Get Run
SpurP009_AA_346-493 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP10_pd Subfamily DSP10 345-494 2e-77 252.5 In-house 10-158 (159) alignment 
Range on Protein: 345-494
Range on HMM: 10-158/159.0
EGIPMTQILPHLYVGNEVDAANIDALRLHGISHVLNVTNSVPCFHEGeSAMRYMRIPVRDNGLINLRMHFQAALEFIEEARRRNARVLVHCHAGISRSST
|..|..|.||.|..|.|.|||..|||. ..|..|||||.|||...|. .|..|.||||.|.. .||...|..|||||||||....||||||.||||||.|
etapasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefee.ealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsat

VVIAYVMKHMNQAMSQAYQFVKNKRPIIAPNLGFVGQLMEFEQILNKMNA
|||||.|||.|.....||.|||.|||||.|||.|.|||.|||. |||..|
vviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnkska
subfamily_DSP6_pd Subfamily DSP6 350-491 5.3e-54 176.0 In-house 15-156 (158) alignment 
Range on Protein: 350-491
Range on HMM: 15-156/158.0
TQILPHLYVGNEVDAANIDALRLHGISHVLNVTNSVPCFHEGESAMRYMRIPVRDNGLINLRMHFQAALEFIEEARRRNARVLVHCHAGISRSSTVVIAY
 .|||.||.|.. ||.|...|. ..|..|||||. .| ..| .  ..|..||..|.   ||  .|  |.|||.|||.... |||||.|||||| ||..||
veilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtlay

VMKHMNQAMSQAYQFVKNKRPIIAPNLGFVGQLMEFEQILNK
.||... .. .||..||.... |.||. |.|||..||. |. 
lmkklalslndaydlvkkrksnisPnfnfmgqlldferslrl
subfamily_DSP1_pd Subfamily DSP1 348-490 2.9e-49 161.3 In-house 17-157 (163) alignment 
Range on Protein: 348-490
Range on HMM: 17-157/163.0
PMTQILPHLYVGNEVDAANIDALRLHGISHVLNVTNSVPCFHEGesAMRYMRIPVRDNGLINLRMHFQAALEFIEEARRRNARVLVHCHAGISRSSTVVI
|...||..||.| | .|.| . |. .||...|||..... ..|    ..|......|.   .. ..|. ..|||.|... | .||.||.||||||||...
PvekildfLylGsetvasnleiLkslgitailnvskeldnvfed..lfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlcl

AYVMKHMNQAMSQAYQFVKNKRPIIAPNLGFVGQLMEFEQILN
||.||. .  ...|..|||..|.|| ||.|||.||...|. | 
aylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkll
subfamily_DSP8_pd Subfamily DSP8 347-491 1.3e-47 155.3 In-house 13-156 (159) alignment 
Range on Protein: 347-491
Range on HMM: 13-156/159.0
IPMTQILPHLYVGNEVDAANIDALRLHGISHVLNVTNSVPCFHEGESAMrYMRIPVRDNGLINLRMHFQAALEFIEEARRRNARVLVHCHAGISRSSTVV
. .|.||..||.| ..|. . ..|.  |||.|||. || |  .| . .  ..|.||.|.   .|   |....|||. |.. |.|||||..||||||.||.
vgptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkesk.flrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatva

IAYVMKHMNQAMSQAYQFVKNKRPIIAPNLGFVGQLMEFEQILNK
|||.||... .. .||.|||.||| | ||| |.|||.|.|. |..
iayimktlemsldeayrfvkekrptispnlnflgqLleyekelkl
0044763 (Phosphotyrosine protein) phosphatases II 333-493 4.2e-46 152.1 In-house 7-174 (178) alignment 
Range on Protein: 333-493
Range on HMM: 7-174/178.0
HILRGGSGICPSEGIPMTQILPHLYVGNEVDAANIDALRLHGISHVLNVTNSVPCFHEGESA-------MRYMRIPVRDNGLINLRMHFQAALEFIEEAR
 .|   .|.. |..|....|||.||.|.  .|.... |. .||.|..|.|. ........ .       ..|..||. |.|  .|. ||....||||||.
vllsnleglersdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeal

-RRNARVLVHCHAGISRSSTVVIAYVMKHMNQAMSQAYQFVKNKRPiIAPNLGFVGQLMEFEQILNKMN
 ... .|||||.||..|| |.|.|| ||...  . .|...|...|| | || |.. ||.|||..|.|..
dekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllkes
PTPc_motif_SM00404 349-487 8e-43 140.7 In-house 2-139 (140) alignment 
Range on Protein: 349-487
Range on HMM: 2-139/140.0
MTQILPHLYVGNEVDAANIDALRLHGISHVLNVTNSVPCFhEGESAMRYMRIPVRDNGLINLRMHFQAALEFIEEARRRNARVLVHCHAGISRSSTVVIA
...||||||.|.. .| | . |  .||.||.|||..|.   . .| .....||..||.  .|  .....|.|||.|.... .||||| ||.||| |..||
psrilphlylgskskaqnpallkklgithvinvteevslt.kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliia

YVMKHMNQAMSQAYQFVKNKRPIIAPNLGFVGQLMEFEQ
|.|. ..  ...||.|||..|||| |||.|| ||.|.|.
YlmryrqlslaeayefvkerRpiispnlnfvrqLieyek
subfamily_Slingshot_pd Subfamily Slingshot 350-492 8.7e-42 136.4 In-house 20-160 (169) alignment 
Range on Protein: 350-492
Range on HMM: 20-160/169.0
TQILPHLYVGNEVDAANIDALRLHGISHVLNVTNSVPCFHEGEsaMRYMRIPVRDNGLINLRMHFQAALEFIEEARRRNARVLVHCHAGISRSSTVVIAY
..|  |.|.| | .|.|.. |. .|....||||. .  |....  ..|..| | |.   .|  ... . .|||.|......|||||  |.|||...||||
skifdhvylGsewnasnleelkengveyilnvtkeidnffpek..feylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviay

VMKHMNQAMSQAYQFVKNKRPIIAPNLGFVGQLMEFEQILNKM
 ||. .  . .|...||..| .| || ||. || |.| ||. .
amkeyglsleealeyvkerrsvikPnkgflkqleeyeGileas
subfamily_DSP14_pd Subfamily DSP14 348-493 4.1e-41 134.6 In-house 6-148 (157) alignment 
Range on Protein: 348-493
Range on HMM: 6-148/157.0
PMTQILPHLYVGnEVDAANIDALRLHGISHVLNVTNSVPCFHEgeSAMRYMRIPVRDNGLINLRMHFQAALEFIEEARRRNARVLVHCHAGISRSSTVVI
 ..|| |.|...  | | . ..|. ..|....|||  .|  .   . ......||.||   .|  ||. . . |||..... ..|||| ||.||| ....
alsqitpsLfls.gvaalskellkkkkitliinvtvelpntkl..kdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslcl

AYVMKHMNQAMSQAYQFVKNKRPIIAPNLGFVGQLMEFEQILNKMN
||.||. . .. .||. ||..|||| ||.||  ||...|. |.. .
aylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgks
subfamily_DSP19_pd Subfamily DSP19 347-489 1.3e-40 133.2 In-house 10-150 (152) alignment 
Range on Protein: 347-489
Range on HMM: 10-150/152.0
IPMTQILPHLYVGNEVDAANIDALRLHGISHVLNVTNSVPCFHEgeSAMRYMRIPVRDNGLINLRMHFQAALEFIEEARRRNARVLVHCHAGISRSSTVV
. .... |.||.|    ||. ..|. ..| |.|||.  ||...   . . |. |.. |.   .|  ....||.||||||. . .|||||.||.|||..||
levgeveprlylgsqdvaadkeilkekkitHilnvatgvpnvfp..kdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvv

IAYVMKHMNQAMSQAYQFVKNKRPIIAPNLGFVGQLMEFEQIL
|||.||. .  ...|.. |...|| | || ||. || |.|. |
iaylmkkeelsleealelvrearpcikPneGFikqLkeyeael
0048179 (Phosphotyrosine protein) phosphatases II 349-489 5.8e-39 128.4 In-house 4-144 (144) alignment 
Range on Protein: 349-489
Range on HMM: 4-144/144.0
MTQILPHLYVGNEVDAANIDALRLHGISHVLNVTNSVPCFHEGESAMRYMRIPVRDNGLINLRMHFQAALEFIEEARRRNARVLVHCHAGISRSSTVVIA
...|||.||.|.  .| ... |. .||..|.|.|.. .  ...   ..|...|. |.|  .|  .....|||||||.... .|||||.||..|. |.|.|
pseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaa

YVMKHMNQAMSQAYQFVKNKRPIIAPNLGFVGQLMEFEQIL
|.||...  . .|...|...||.. || |.. .|.|.|..|
ylmkklglsleealalvrsrrpgavpnpgqlrfLleyekll
DSPc Dual specificity phosphatase, catalytic domain 356-487 3.8e-38 125.3 Pfam-A 1-132 (133) alignment 
Range on Protein: 356-487
Range on HMM: 1-132/133.0
LYVGNEVDAAnIDALRLHGISHVLNVTNSVPC-FHEGESAMRYMRIPVRDNGLINLRMHFQAALEFIEEARRRNARVLVHCHAGISRSSTVVIAYVMKHM
||.|.. .|   . |  .||..|.|||..||  .   .|  .|.||||.|.   ..  ....| ||||.|.... .||||| |||||| |..||| || .
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

NQAMSQAYQFVKNKRPIIAPNLGFVGQLMEFEQ
|  ...||.|||..|..| || ||..||.|.|.
nlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 356-487 3.8e-38 125.3 In-house 1-132 (133) alignment 
Range on Protein: 356-487
Range on HMM: 1-132/133.0
LYVGNEVDAAnIDALRLHGISHVLNVTNSVPC-FHEGESAMRYMRIPVRDNGLINLRMHFQAALEFIEEARRRNARVLVHCHAGISRSSTVVIAYVMKHM
||.|.. .|   . |  .||..|.|||..||  .   .|  .|.||||.|.   ..  ....| ||||.|.... .||||| |||||| |..||| || .
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

NQAMSQAYQFVKNKRPIIAPNLGFVGQLMEFEQ
|  ...||.|||..|..| || ||..||.|.|.
nlslneAyefvkerrskispnagflrqLleyer
subfamily_DSP12_pd Subfamily DSP12 349-495 5.1e-38 124.9 In-house 2-149 (155) alignment 
Range on Protein: 349-495
Range on HMM: 2-149/155.0
MTQILPHLYVGNEVDAANIDALRLHGISHVLNVTNS-VPCFHEGESAMRYMRIPVRDNGLINLRMHFQAALEFIEEARRRNARVLVHCHAGISRSSTVVI
...||| ||.|.  .... . |.  .|.||| |..  .| ... .. ...  |...|.   ..  |.. |..|||||. ..  |||||.||.|||.|.||
vsrilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtivi

AYVMKHMNQAMSQAYQFVKNKRPIIAPNLGFVGQLMEFEQILNKMNAP
||.||. .  ...|...||.|.| | || ||. ||  ||..  |..  
AYlmkkeklslekAlklvkekkpeiepNegFleQLklfekmgckvdts
0048076 (Phosphotyrosine protein) phosphatases II 349-489 7.8e-38 124.7 In-house 4-142 (145) alignment 
Range on Protein: 349-489
Range on HMM: 4-142/145.0
MTQILPHLYVGNEVDAANIDALRLHGISHVLNVTNSVPCFHegESAMRYMRIPVRDNGLINLRMHFQAALEFIEEARRRNARVLVHCHAGISRSSTVVIA
...|||.||.|.  .| ... |. .|| .|||.|.  . .   .  ..|...|. |.|  .|  .....|||||||.... .|||||.||..|. |.|.|
pseilpglylgslptaldlellkdlgittvlnltselelle..rlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaa

YVMKHMNQAMSQAYQFVKNKRPIIAPNLGFVGQLMEFEQIL
|.|....  . .|...|...||.. || |.. .|.|||..|
ylmlllgvsleealelvrsqrpgavpnpgqlrflyefelel
0041856 (Phosphotyrosine protein) phosphatases II 341-493 1.5e-37 124.3 In-house 11-176 (182) alignment 
Range on Protein: 341-493
Range on HMM: 11-176/182.0
ICPSEGIPMTQILPHLYVGNEVD--------------AANIDALRLHGISHVLNVTnSVPCFHEGESA--MRYMRIPVRDNGLINlrmhFQAALEFIEEA
...  ......|...||.|.  .              |.... |. .||....|.| ... . | .    ..|...|. |.|  .    .. .|.||||.
lpydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.eelywpellerlgiqylylpwpDhgvpd....ldelldfieev

RRRNARVLVHCHAGISRSSTVVIAYVMKHMNQAMSQAYQFVKNKRP--IIAPNLGFVGQLMEFEQILNKMN
.... .|||||.||..|. |.|.||.||...  . .|...|...||  .| || .|. ||...| .|.|..
leeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkkt
subfamily_DSP3_pd Subfamily DSP3 350-491 1.1e-36 119.9 In-house 12-159 (162) alignment 
Range on Protein: 350-491
Range on HMM: 12-159/162.0
TQILPHLYVGNEVDAANIDALRLHGISHVLNVTNS----V---PCFHEgESAMRYMRIPVRDNGLINLRMHFQAALEFIEEARRR-NARVLVHCHAGISR
 .. |.||||.|  | . . |.  || |||| ...    |   . |.. .. ..|. ..|.|.  ..|. .|. | .||.||  . ...|||||..|.||
devypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefyk.dleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsR

SSTVVIAYVMKHMNQAMSQAYQFVKNKRPIiAPNLGFVGQLMEFEQILNK
|.|.|.||.| . . .. .| . |..|| |  || ||. ||.|... |..
satlvlayLmirrkmtlveairtvrkkRei.lPneGFlkqLaeldeelkr
subfamily_DSP15_pd Subfamily DSP15 349-488 1.9e-35 116.2 In-house 2-138 (151) alignment 
Range on Protein: 349-488
Range on HMM: 2-138/151.0
MTQILPHLYVGNEVDAANIDALRLHGISHVLNVTNSVPCFHEGesaMRYMRIPVRDNGLINLRMHFQAALEFIEEARRRNARVLVHCHAGISRSSTVVIA
....|| ||.||  |. . . |. . |.|.|.| ..   . .    ..|  |.. |    .|  .|. . ||| ..| ..  ||||| ||.||| |.|.|
iskvlpglylgnfrdskdeelLkeknithilsvhdnakkllkd...ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvva

YVMKHMNQAMSQAYQFVKNKRPIIAPNLGFVGQLMEFEQI
|.|  ..    .| ...|..| .  ||.||  ||.|.|. 
YlmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyekt
PTEN_1 333-491 5.2e-35 116.0 In-house 26-193 (196) alignment 
Range on Protein: 333-491
Range on HMM: 26-193/196.0
HILRGGSGICPSEGIPMtQILPHLYVGNEVDA-ANIDALRLHGISHVLNVTNSV-----PCFHE--GESAMRYMRIPVRDNGLINLRMHFQAALEFIEEA
.  . ..| .||....  .| ..||.|.. |. |. | |  .|| .|.|...       .. .|   .| ..| ..|..| |  .|...| .. .||| .
tsriiamgkapsrpllq.eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewl

RR--RNARVLVHCHAGISRSSTVVIAYVMKHMNQAMSQAYQFVKNKRPIIAPNLGFVGQLMEFEQILNK
..  ..  |||||.||..|| |||.|| |....  . .| ..|. ||| .||| ..  .|.|... |..
lsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaella
0043147 (Phosphotyrosine protein) phosphatases II 350-490 5.8e-35 115.9 In-house 20-161 (172) alignment 
Range on Protein: 350-490
Range on HMM: 20-161/172.0
TQILPHLYVGNEVDAANIDALRLHGISHVLNVTNS-VPCFHEGESAMRYMRIPVRDNGLInLRMHFQAALEFIEE--ARRRNARVLVHCHAGISRSSTVV
............ .| ... |. .||.|..|.|.  ... .. .. ..|...|. |.|   |  ... .||||.|  |.... .|||||.||..|. |.|
drfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlv

IAYVMKhMNQAMSQAYQFVKNKRPIIAPNLGFVGQLMEFEQILN
.|| |. ..  . .|...|..|||.. .| ..  .|..||..| 
aaylml.lglsleeavalvrekRpgavqnpsqyrflyyfeklll
0049772 (Phosphotyrosine protein) phosphatases II 348-493 1.9e-33 111.9 In-house 155-277 (314) alignment 
Range on Protein: 348-493
Range on HMM: 155-277/314.0
PmtqilphlyvgNEVDAANIDALRlhgishvlnvtnsvPCFHEGESA----MRYMRIPVRDnGLINLRMHFQAALEFIEEArRRNARVLVHCHAGISRSS
.           || .||... |.              .. ...|      ..|.|||| | |  .|  .|...||||||| ... .|||||.||..|. 
g...........neptaadlellk..............eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtg

T-VVIAYVMKHMNQAMSQAYQFVKNKRPiIAPNLGFVGQLMEFEQILNKMN
| ||.||.||...  . .|...|..||| | || ||. ||...|.||. ..
tfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefileall
0049260 (Phosphotyrosine protein) phosphatases II 349-490 9.6e-33 108.4 In-house 8-150 (152) alignment 
Range on Protein: 349-490
Range on HMM: 8-150/152.0
MTQILPHLYVGNEVDAANIDALRLHGISHVLNVTNSVPCFHEGESA-MRYMRIPVRDNGLINLRMHFQAALEFIEE-ARRRNARVLVHCHAGISRSSTVV
..........|..  | ... |. .||......|. ..  ....   ..|...|. |.|  .| .... .|.|||. |.... .|||||.||..|. |.|
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlv

IAYVMKhMNQAMSQAYQFVKNKRPIIAPNLGFVGQLMEFEQILN
.|| |. ..  . .|...|..|||.. || |.  .|.|||..|.
aaylml.lgvsleeavalvrekRpgavpnpgqlrflyefekllk
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 354-487 2.4e-32 105.5 In-house 13-145 (148) alignment 
Range on Protein: 354-487
Range on HMM: 13-145/148.0
PHLYVGNEVDAANIDALRLHGISHVLNVTNSVPCFHEGEsAMRYMRIPVRDNGLINLRMHFQAALEFIEEARRRNARVLVHCHAGISRSSTVVIAYVMKH
 .|..|.   ||...||.  |.... | |.. .   .   ...|. ....|.   .|.  |. . .|...|. .  |||||.. |.|||| .........
afLFlGskksaadlealkalgvtrivnatkerdnaldqr.gieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidf

MNQAMSQAYQFVKNKRPIIAPNLGFVGQLMEFEQ
 . .. .|...||.||. . |||||. || |.||
krvslkealalvkskrryvdpnlgfLkqLaeleq
0046846 (Phosphotyrosine protein) phosphatases II 345-490 3.3e-32 107.0 In-house 8-173 (176) alignment 
Range on Protein: 345-490
Range on HMM: 8-173/176.0
EGIPMTQILPHLYVGNEV----------DAANIDALRLHGISHVLNVTNSVPCFH---------EGESAMRYMRIPVRDNGLINLrMHFQAALEFIEEAR
.. ....|...|..|.             |.... |. .||..|.|.|. |   .         . .  ..|...|..|.|  .|  ... .||||.||.
ldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefireal

RRNARVLVHCHAGISRSSTVVIAYVMKH-MNQAMSQAYQFVKNKRP-IIAPNLGFVGQLMEFEQILN
... .|||||.|||.|. |.|.|| ... ..  . .|...|...||  . .. ... .|.|||. |.
keggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefellll
subfamily_LRR-DSP_pd Subfamily LRR-DSP 350-493 5.3e-32 104.9 In-house 121-262 (263) alignment 
Range on Protein: 350-493
Range on HMM: 121-262/263.0
TQILPHLYVGNEVDAANIDALRLHGISHV-LNVTNSVPCFHEgesAMRYMRI-PVRDNGLINLRMHFQAALEFIEEARRrNARVLVHCHAGISRSSTVVI
 .|...|..|    | |   |.  |..|. | |..  | | .    ..|. |  ..|    ..  ||.    |||| |. .  ||||| ||.|||||.||
deiidklflGgldsannksilkdlgvthillavadfePlfPk...lfkylsiddiedvdeadisqhfeetnafieeGrk.kGGvlvhcraGvsrsstlvi

AYVMKHMNQAMSQAYQFVKNKRPIIAPNLGFVGQLMEFEQILNKMN
.|.||. .  . .|. .|..||| | || ||. ||. .|. | . |
sylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklfctn
0045098 (Phosphotyrosine protein) phosphatases II 349-491 6.2e-30 99.9 In-house 22-273 (278) alignment 
Range on Protein: 349-491
Range on HMM: 22-273/278.0
MTQILPHLYVGNEV-----------------------------------------DAANIDALRLHGISHVLNVTNSVPC--------------------
. .|.|.||.||                                            |.... |. .||......|. |.                     
pseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdf

---------------------------FHEGESAMRYMRI-PVRDNGLINLR--MHFQAALEFIEEARR--------------RNARVLVHCHAGISRSS
                            .  .  .... . |. |.|  .|   ..|. .||||.||..              .. .|||||.||..|. 
tvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtG

TVVIAYVMKHM---NQAMSQAYQFVKNKRPI-IAPNLGFVGQLMEFEQILNK
|.|.|| |...   .  . .|.......||. . .||..  .|.||.. | .
tlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllelll
0036282 (Phosphotyrosine protein) phosphatases II 347-490 2.5e-29 97.6 In-house 10-170 (174) alignment 
Range on Protein: 347-490
Range on HMM: 10-170/174.0
IPMTQILPHLYVGNEVDAaNIDALRLHGISHVLNVTNSVPC-------------FHEGESAMRYMRIPVRDNGLINLRMhFQAALEFIEEARRR--NARV
. .. |.|.|..|.   | ... |. .||..|........               .. .. ..|...|. |.|  .| . .. ...|.|||. .  .  |
ldlsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpv

LVHCHAGISRSSTVVIAYVMKHMNQ-AMSQAYQFVKNKR---PIIAPNLGFVGQLMEFEQILN
||||.||..|. |.|.|| |...    . .|...|. .|   | . .. ..  .| .||..|.
lVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfeklls
subfamily_STYX_pd Subfamily STYX 349-489 1.2e-27 90.0 In-house 12-157 (166) alignment 
Range on Protein: 349-489
Range on HMM: 12-157/166.0
MTQILPHLYVGNEVDA--ANIDALRLHGISHVLNVTNSVPC-F--HEGESAMRYMRIPVRDNGLINLRMHFQAALEFIEEARRRNARVLVHCHAGISRSS
| .||| |..|    |  . .. |. |||.|.. . ... . .   . .  .||. . | || . |.  ..    |||... ..  .||||  ||||||.
mqeilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsa

TVVIAYVMKHMNQAMSQAYQFVKNKRPIIAPNLGFVGQLMEFEQIL
..||||.|. .  .  .|...|...|  |.|| ||| ||.|.| | 
alviayimetyglkyreafayvqerrfcinpnegfvsqlkeyeaiy
0037934 (Phosphotyrosine protein) phosphatases II 349-488 4.3e-27 90.6 In-house 39-240 (243) alignment 
Range on Protein: 349-488
Range on HMM: 39-240/243.0
MTQILPHLYVGNE--------VDAANIDALRLHGISHVLNVTNSV-------------------------------------------PCFHEGESAMRY
.....|.|....         ..|.... |  .||......|. |                                           .. ..    ..|
liyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihy

MRIPVRD----NGLINLRMHFQAALEFIEE-----ARRRNARVLVHCHAGISRSSTVVIAYVMKHM-NQAMSQAYQFVKNKRPI-IAPNLGFVGQLMEFE
...|. |    .   .|  ..... |||||     |. .. .|||||.||..|. |...||.|... .  . .|.......||  . .....  .|.|..
hylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeal

QI
. 
le
subfamily_MKPLT_pd Subfamily MKPLT 355-489 2.1e-26 86.4 In-house 28-160 (164) alignment 
Range on Protein: 355-489
Range on HMM: 28-160/164.0
HLYVGNEVDAANIDALRLHGISHVLNVTNSvpCFHEGESAMRYMRIPVRDNGLINLRMHFQAALEFIEEARRRNARVLVHCHAGISRSSTVVIAYVMKHM
.|| ||  .| |   |.   | |..||..   . .    .. |... | |.   .|  ... | .|. .|     ||||||  | ||||.| .|...|  
tlylGnakhatnekvlkdlkithivnvsqe..kkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLiksk

NQAMSQAYQFVKNKRPIIAPNLGFVGQLMEFEQIL
   . .||...|..| |.||| ||. || .||...
gwtlkeayeylkerrsivapnrGflkqlakfeeli
subfamily_MKPLV_pd Subfamily MKPLV 355-489 2.1e-26 86.4 In-house 28-160 (164) alignment 
Range on Protein: 355-489
Range on HMM: 28-160/164.0
HLYVGNEVDAANIDALRLHGISHVLNVTNSvpCFHEGESAMRYMRIPVRDNGLINLRMHFQAALEFIEEARRRNARVLVHCHAGISRSSTVVIAYVMKHM
.|| ||  .| |   |.   | |..||..   . .    .. |... | |.   .|  ... | .|. .|     ||||||  | ||||.| .|...|  
tlylGnakhatnekvlkdlkithivnvsqe..kkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLiksk

NQAMSQAYQFVKNKRPIIAPNLGFVGQLMEFEQIL
   . .||...|..| |.||| ||. || .||...
gwtlkeayeylkerrsivapnrGflkqlakfeeli
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 355-487 5.3e-26 84.8 In-house 9-150 (154) alignment 
Range on Protein: 355-487
Range on HMM: 9-150/154.0
HLYVGNEVDAANIDALRLHGISHVLNV-TNSVPCFHEGE------SAMRYMRIPVRDNGLINLRMHFQAALEFIEEAR--RRNARVLVHCHAGISRSSTV
.||..    | |   |.|. | ..||| . .   | . .        . |... . |.   ..  ... |.|||..|    .| .||||...|.|||...
flyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaal

VIAYVMKHMNQAMSQAYQFVKNKRPIIAPNLGFVGQLMEFEQ
.|.|.|.... ..|.|....|. |.|| || ||. ||  ||.
lisylmdklkislslalellkdsryiikPnqGflkqleifek
0042113 (Phosphotyrosine protein) phosphatases II 347-488 1.2e-25 85.7 In-house 45-241 (245) alignment 
Range on Protein: 347-488
Range on HMM: 45-241/245.0
IPMTQILPHLYVGNEVDAANID----ALRLHGISHVLNVTNSVP--------------------------------------------CFHEGESAMRYM
... .| |......   . ...     |. .||......|. ..                                              .|    ..|.
vdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyh

RIPVRDNGLINLRMHFQAALEFIEEARR--RNARVLVHCHAGISRSSTVVIAYVM-----KHMNQAMSQAYQFVKNKRPIIAPNLGFVGQLMEFEQI
..|. |.|  .|  ... .|||...|..  .| .|||||.||..|. |...|| |     |...  . .|.......|| . .....  .|.|... 
ylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
0051082 (Phosphotyrosine protein) phosphatases II 347-485 1.6e-25 84.9 In-house 6-149 (151) alignment 
Range on Protein: 347-485
Range on HMM: 6-149/151.0
IPMTQILPHLYVGNEVDAANIDALRLHGISHVLNVTNSV---PCFHEGES-AMRYMRIPVRDNGLINLRMHFQAALEFIEEARRR-NARVLVHCHAGISR
| .... ..||...   |.... |. .||....|... .    | .  ..  .....||. |.   .| ..|.|.|||.|....  |  |||||.||..|
infsyvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgR

SSTVVIAYVMKhMNQAMSQAYQFVKNKRP-IIAPNLGFVGQLMEF
. |.|..| |. ..  . .|..... ||| .. || .|. ||...
TGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfal
subfamily_STYXL1_pd Subfamily STYXL1 351-489 2.1e-25 82.8 In-house 13-153 (157) alignment 
Range on Protein: 351-489
Range on HMM: 13-153/157.0
QILPH-LYVGNEVDAANIDALRLHGISHVLNVTNSVPCFHEGESA-MRYMRIPVRDNGLINLRMHFQAALEFIEEARRRNARVLVHCHAGISRSSTVVIA
..||. ||.||. .| |    .   .  ..||..    . .| .   . ..|.| |.   .|  ... | .|||. ....  |||  . ||||| .|.||
evlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviia

YVMKHMNQAMSQAYQFVKNKRPIIAPNLGFVGQLMEFEQIL
|.| . .... .||...|. .. . || .|| || |.|. |
ylmyskkitlkkaykylkkCkenvkPnrafveqlseWekql
0040439 (Phosphotyrosine protein) phosphatases II 343-488 5.1e-25 83.9 In-house 23-244 (249) alignment 
Range on Protein: 343-488
Range on HMM: 23-244/249.0
PSEGIPMTQILPHLYVGNEVDAANIDA------------------------LRLHGISHVLNVTNSVPCF------------------------------
.    .  .||| |. .. ..|  ||                         |. .||......|. |..                               
ydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkd

-----------HEGESAMRYMRIPVRDNGLINLRMHFQAALEFIEEARR------RNARVLVHCHAGISRSSTVVIAYVM-----KHMNQAMSQAYQFVK
           ..  .  ... |.. |    ..  .|. .|.|||..|       .. .|||||.||..|. |...|| |     |. .  . .|.....
dytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllr

NKRPIIAPNLGFVGQLMEFEQI
..|| . .|...  .|.|... 
sqRpgavqnpeqyrflyealle
0045450 (Phosphotyrosine protein) phosphatases II 368-488 6.4e-24 80.7 In-house 125-302 (307) alignment 
Range on Protein: 368-488
Range on HMM: 125-302/307.0
DALRLHGISHVLNVTNSVPCF----------------------------HegESAMRYMRIPVRDN-----------------GLINLRMHFQAALEFIE
  |. .|.......|..|..                             |  .. . .....| |.                    ..  .|. .|.|||
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh..ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfie

EARR------RNARVLVHCHAGISRSSTVVIAYVMKHMN--------QAMSQAYQFVKNKRPIIAPNLGFVGQLMEFEQI
|.|.      .. .|||||.||..|. |...||.|...           . .|.......|| . .|...  .|.|... 
evrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 355-490 1.1e-21 70.5 In-house 5-142 (145) alignment 
Range on Protein: 355-490
Range on HMM: 5-142/145.0
HLYVGNEVDAANIDALRLHGISHVLNV--TNSVPCFHEGESAMRYMRIPVRDNGLINLRMHFQAALEFIEEARRRNARVLVHCHAGISRSSTVVIAYVMK
.||||  . | .. .|.  ||| ..|.  ...| . .     .  . |   |    .|  ||.   .||.  .   | |.||| ||.||| || .|..||
rlyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmk

HMNQAMSQAYQFVKNKRPIIAPNLGFVGQLMEFEQILN
. | ..|.| . |. .|    ||. |. .|...|. | 
ycnmtlseaarqvrsnrllaypnvtflknllnlekqlk
0039614 (Phosphotyrosine protein) phosphatases II 370-492 2.3e-21 72.0 In-house 121-291 (297) alignment 
Range on Protein: 370-492
Range on HMM: 121-291/297.0
LRLHGISHVLNVTNSVPC-------------------------FHEGESAM---------------RYMRIPVRDNGLINLRMHFQAALEFIEEARR---
.. .|.......|. |..                         .|..   .               ..  ..  |.|  ..  ... .||...||..   
vweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelp

RNARVLVHCHAGISRSSTVVIAYVM-----KHMNQAMSQAYQFVKNKRPIIAPNLGFVGQLMEFEQILNKM
.. .|||||.||..|. |...|| |     |. .  . .|.......|| . .....  .|..... | | 
kggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
0051429 (Phosphotyrosine protein) phosphatases II 350-489 3.5e-21 71.5 In-house 17-224 (272) alignment 
Range on Protein: 350-489
Range on HMM: 17-224/272.0
TQILPH-LYVGNEV---DAANIDALRLHGISHVLNVTNSV-----PCFHEGeSAMRYMRIPVRDNGLINLRMHF--------------------------
 ...|. || ..     .||....|. .||........ .     .|. .    .||...|. |..    ....                          
rvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdryw.pgirylhlpilddsaptilygalrvtllseellldyilrellltllls

----------------------QAALEFIEEARRrNARVLVHCHAGISRSSTVVIAYVMKhMNQA--------------MSQAYQFVKNKRPIIAPNLGF
                      .| ||..|. .. . .|||||.||..|. ||| .. .  ..                . .|.. .. .|| . .. ..
agearevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeq

VGQLMEFEQIL
. .|.|... |
ylflyeallel
0040438 (Phosphotyrosine protein) phosphatases II 373-493 5e-21 70.7 In-house 109-279 (317) alignment 
Range on Protein: 373-493
Range on HMM: 109-279/317.0
HGISHVLNVTNSVPC---------------------------FHegESAMRYMRIPVRDN----------------GLINLRMHFQAALEFIEEARRR--
.|.......|.....                           ..  .. . . ...| |.                   ..  ...  |.|.|..|.   
qgvtvivmLteleelgrekcaqYwplgetltygdftvtllseee..lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale

--NARVLVHCHAGISRSSTVVIAYVM-----KHMNQAMSQAYQFVKNKRPIIAPNLGFVGQLMEFEQILNKMN
  .  |||||.||..|. |...||.|     |...  . .|.......|| . .....  .|..... . | .
dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk
subfamily_MSG5_pd Subfamily MSG5 377-492 3.7e-20 65.7 In-house 50-163 (165) alignment 
Range on Protein: 377-492
Range on HMM: 50-163/165.0
HVLNVTNSVPCFHEGESAMRYMRIPVRDNGLINLRMhfQAALEFIEEARRRNARVLVHCHAGISRSSTVVIAYVMKHMNQAMSQAYQFVKNKRPIIAPNL
 |.||.. .. ..    |..|  |    .  | . .      . |  |. .. ..||||  |.|||.....||.||. | .. .||. .|..   |.|..
lvinvakeindlellvpavkyyhiewehdskivkdl..srltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsi

GFVGQLMEFEQILNKM
|.. ||||.| .|.| 
glifqlmewevalskk
0038934 (Phosphotyrosine protein) phosphatases II 353-491 9.7e-20 66.5 In-house 35-178 (194) alignment 
Range on Protein: 353-491
Range on HMM: 35-178/194.0
LPHLYVGNEVDAANIDALRLHGISHVLNVTNSVPCFHEGES---AMRYMRIPVRDNGLI----NLRMHFQAALEFIEEarRRNARVLVHCHAGISRSSTV
.. ||. .  |  .   |. ... .|...||. ....  |     ..|...|. | | .    .|.  .... ||..|    .  |.|||.||..|. |.
ieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflne..dpggvvaVHCkaGlgRtGtl

VIAYVMKHMNQAMSQAYQFVKNKRPIIAPNLGFVGQLMEFEQILNK
|.|| .....  . .|..... ||| . || ... .|... . |.|
vaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykelrk
0036941 (Phosphotyrosine protein) phosphatases II 372-491 1.1e-18 63.1 In-house 100-278 (297) alignment 
Range on Protein: 372-491
Range on HMM: 100-278/297.0
LHGISHVLNVTNSVPC--------FH-----------------------EGESAMRYMRIPV--------------RDNGLINLRMHFQAALEFIEEARR
 .........|. |.         ..                       ...  .|....                 .    ..  ...  |.|||..|.
eqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrk

------RNARVLVHCHAGISRSSTVVIAYVM--------KHMNQAMSQAYQFVKNKRPIIAPNLGFVGQLMEFEQILNK
      .. .|||||.||..|| |...|..|        |. .  . .|.......|| . ..|..  .| |... | |
vlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellk
subfamily_PTPMT1_pd Subfamily PTPMT1 394-489 2.5e-18 61.1 In-house 73-168 (171) alignment 
Range on Protein: 394-489
Range on HMM: 73-168/171.0
AMRYMRIPVRDNGLINLRMHFQAALEFIEEARRRNARVLVHCHAGISRSSTVVIAYVMKHMNQAMSQAYQFVKNKRPIIAPNLGFVGQLMEFEQIL
 . ...... |      . . . ..||||. . .  || |||.|| .||.|.|..|.||. .  . .| ...|.||.||  .   . .| |.|. |
gveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeekl
0043336 (Phosphotyrosine protein) phosphatases II 373-487 1.4e-17 59.5 In-house 111-274 (278) alignment 
Range on Protein: 373-487
Range on HMM: 111-274/278.0
HGISHVLNVTNSVP-------------------------------------------CFHEGESAMRYMRIPVRDNGLI-NLRMHFQAALEFIEEARRRN
.|.......|. |                                              .|    ..|  ... |.|.  .| ....   ...|  . .|
lgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsn

ARVLVHCHAGISRSSTVVIAYVM-----KHMNQAMSQAYQFVKNKRPIIAPNLGFVGQLMEFEQ
  |||||.||..|. |....|..     |. .  . .|.......|| . ... .  .| |...
gpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall
Rhodanese Rhodanese-like domain 185-297 3.9e-15 48.3 Pfam-A 10-112 (113) alignment 
Range on Protein: 185-297
Range on HMM: 10-112/113.0
RSGSVILVDIRPFLAFSRRHISGALNVNCATRfscrrlrEGKVALVDLVTSEEGKKEFQGRLDQDKEVVVYDeesqGIDNLPVNHPTSLVVSALKKEGV-
....|.|.|.|.. .... || ||.||.  .         .. .| .    .|  .| . .||.||.||||.      .|   .. ..|.   ||. |  
ekekvvllDvRspeeyakghIpgAvnvpldsl.......yprrdlffkdklaeeleesgkkldkdktvvvyc....rsgnrsggaaalllalilkelgyk

NVRLLKGGIKEFAN
||..|.||......
nvyvLdGGfeawka
0047943 (Phosphotyrosine protein) phosphatases II 403-483 2.8e-13 45.4 In-house 177-265 (273) alignment 
Range on Protein: 403-483
Range on HMM: 177-265/273.0
RDNGLINLRMHFQAALEFIEEARR---RNARVLVHCHAGISRSSTVVIAYVM-----KHMNQAMSQAYQFVKNKRPIIAPNLGFVGQLM
 |.|      ..   .|....|..   .|  |.|||.||..|. |.......     |. .  . .|.......|| . ... .  .|.
pdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfly
0051299 (Phosphotyrosine protein) phosphatases II 404-476 8.5e-12 40.6 In-house 194-272 (288) alignment 
Range on Protein: 404-476
Range on HMM: 194-272/288.0
DNGLINlrmHFQAALEFIEEARRR----NARVLVHCHAGISRSSTVVIAYVM-----KHMNQAMSQAYQFVKNKRPIIAPNL
|.|  .   .... |.|....|.     .  |.|||.||..|. |.......     |.    . .|.......|| . ...
dhgvpd...spellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp
0050432 (Phosphotyrosine protein) phosphatases II 414-475 5.1e-11 37.9 In-house 216-284 (308) alignment 
Range on Protein: 414-475
Range on HMM: 216-284/308.0
FQAALEFIEEARRR--NARVLVHCHAGISRSSTVVIAYVM-----KHMNQAMSQAYQFVKNKRPIIAPN
... |.|.|..|..  .  ..|||.||..|. |.......     |. .  . .|..... .||   ..
peilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqt
0046845 (Phosphotyrosine protein) phosphatases II 404-472 7.6e-11 37.4 In-house 177-256 (284) alignment 
Range on Protein: 404-472
Range on HMM: 177-256/284.0
DNGLINLRMHFQAALEFIEEARRR---NARVLVHCHAGISRSSTVVIAYVMKHM--------NQAMSQAYQFVKNKRPII
|.|      .... |....|....   .  ..|||.||..|. |..........        .  . .|.......||  
dhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgm
subfamily_DSP23_pd Subfamily DSP23 370-471 3.9e-09 31.3 In-house 27-127 (148) alignment 
Range on Protein: 370-471
Range on HMM: 27-127/148.0
LRLHGISHVLNVTNSVPCFHEGESAMRYMRIPVRDNGLINLRmHFQAALEFIEEARRRNARVLVHCHAGISRSSTVVIAYVMKHMNQAMSQAYQFVKNKR
|   |. ... .|.  .   |   .. ..|. . |     |    .  .. .|||  .|  | |||  |  |. |..  |..|. . | ..|   |...|
lldlgvrylvslteegrphveatpnltlvrlriddyhppale.qvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlr

PI
| 
pg
subfamily_PTPDC1_pd Subfamily PTPDC1 427-491 4.5e-09 31.0 In-house 113-177 (182) alignment 
Range on Protein: 427-491
Range on HMM: 113-177/182.0
RNARVLVHCHAGISRSSTVVIAYVMKHMNQAMSQAYQFVKNKRPIIAPNLGFVGQLMEFEQILNK
.. .| ||||||  |   .. .|.. . . . ..| ..|..|||      . |  . ||.. | .
qegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelvkefalflip
PTPc_DSPc_SM00012 415-469 7e-09 31.2 In-house 20-71 (105) alignment 
Range on Protein: 415-469
Range on HMM: 20-71/105.0
QAALEFIEEARRR------NARVLVHCHAGISRSSTVVIAYVMKHMNQAMSqayqfvknkR
.. ||.... ..       .. |.|||.||..|. |.| .... ..... .         .
dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket.........k
PTPlike_phytase Inositol hexakisphosphate 393-451 9.1e-09 30.1 Pfam-A 91-147 (149) alignment 
Range on Protein: 393-451
Range on HMM: 91-147/149.0
SAMRYMRIPVRDNGLINlRMHFQAALEFIEEArRRNARVLVHCHAGISRSSTVVIAYVM
  ..|.|||. |. . .   .. | ...|...  |.. ....|.||  |..|... . .
fgvkYvRipitdeqape.eedvDafvrliksl.prdtalvfnCqaGrgRTTtamviadL
PTPlike_phytase Inositol hexakisphosphate 393-451 9.1e-09 30.1 In-house 91-147 (149) alignment 
Range on Protein: 393-451
Range on HMM: 91-147/149.0
SAMRYMRIPVRDNGLINlRMHFQAALEFIEEArRRNARVLVHCHAGISRSSTVVIAYVM
  ..|.|||. |. . .   .. | ...|...  |.. ....|.||  |..|... . .
fgvkYvRipitdeqape.eedvDafvrliksl.prdtalvfnCqaGrgRTTtamviadL
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 358-457 2.2e-08 28.5 In-house 141-239 (307) alignment 
Range on Protein: 358-457
Range on HMM: 141-239/307.0
VGNEVDAANIDALRLHGISHVLNVTNSVPCFHEGESAMRYMR-IPVRDNGLINLRMhfqAALEFIEEARRRNARVLVHCHAGISRSSTVV-IAYVMKHMN
 .| .  ||. | .|    ...|||.    . ..  ......     |.|  .. .   .|....|  |  .  |.||| ||. || |.| |..|.  | 
apntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinl...tainlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmi

QA
. 
aG
0048567 (Phosphotyrosine protein) phosphatases II 403-470 2.7e-08 28.4 In-house 46-119 (157) alignment 
Range on Protein: 403-470
Range on HMM: 46-119/157.0
RDNGLINLRMHF---QAALEFIEEARRRNARVLVHCHAGI---SRSSTVVIAYVMKHMNQAMSQAYQFVKNKRP
.|.| .|| . .   . . .|..  . .. .. |||.||    .|. |.. .| ..|..   ..|.....  ||
fdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrp
subfamily_Laforin_pd Subfamily Laforin 395-472 3.3e-07 23.4 In-house 77-154 (183) alignment 
Range on Protein: 395-472
Range on HMM: 77-154/183.0
MRYMRIPVRDNGLINLRMHFQAALEFIEEARRRNARVLVHCHAGISRSSTVVIAYVMKHMNQAMSQAYQFVKNKRPII
. |. .|. |    .    .  |. ..     .  .| ||| ||. ||...|  ...  .. ....   |.  |||..
layiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvv
Y_phosphatase Protein-tyrosine phosphatase 415-469 3.4e-07 25.3 Pfam-A 153-216 (235) alignment 
Range on Protein: 415-469
Range on HMM: 153-216/235.0
QAALEFIEEARRRN----ARVLVHCHAGISRSSTVV-IAYVMKHMNQ----AMSQAYQFVKNKR
.. |..|.. ....    . |.||| ||..|. |.| . ........     . |. . ....|
kslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqR
Y_phosphatase Protein-tyrosine phosphatase 415-469 3.4e-07 25.3 In-house 153-216 (235) alignment 
Range on Protein: 415-469
Range on HMM: 153-216/235.0
QAALEFIEEARRRN----ARVLVHCHAGISRSSTVV-IAYVMKHMNQ----AMSQAYQFVKNKR
.. |..|.. ....    . |.||| ||..|. |.| . ........     . |. . ....|
kslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqR
DSPc_SM00195 413-497 7e-07 24.2 In-house 179-242 (263) alignment 
Range on Protein: 413-497
Range on HMM: 179-242/263.0
HFQAALEFIEEARR-RNARVLVHCHAGISRSSTVVIAYVMKHMNQAMSQayqfvknkrpiiapnlgfvgqlMEFEQILNKMNAPRS
.. . |..... ..  .. ..|||.||..|. |.| . .. .  .. ..                      .....|....   | 
svlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekk......................vdifeivkelRkqRp
PTPc_SM00194 413-497 7e-07 24.2 In-house 179-242 (263) alignment 
Range on Protein: 413-497
Range on HMM: 179-242/263.0
HFQAALEFIEEARR-RNARVLVHCHAGISRSSTVVIAYVMKHMNQAMSQayqfvknkrpiiapnlgfvgqlMEFEQILNKMNAPRS
.. . |..... ..  .. ..|||.||..|. |.| . .. .  .. ..                      .....|....   | 
svlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekk......................vdifeivkelRkqRp
subfamily_RNGTT_pd Subfamily RNGTT 375-470 7.8e-07 23.0 In-house 55-155 (189) alignment 
Range on Protein: 375-470
Range on HMM: 55-155/189.0
ISHVLNVTNSVPCFHEGES---AMRYMRIPVRDNGLINLRMHFQAALEFIEE--ARRRNARVLVHCHAGISRSSTVVIAYVMKHMNQAMSQAYQFVKNKR
.  |...||  . ... |     ..|... .. .|      . .   . .||  ... .  . |||. |  |.  ....|...... ....| .  .. |
lglvidltntsryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaR

P
|
p
subfamily_CDC14_pd Subfamily CDC14 419-470 1.3e-06 22.5 In-house 254-305 (328) alignment 
Range on Protein: 419-470
Range on HMM: 254-305/328.0
EFIEEARRRNARVLVHCHAGISRSSTVVIAYVMKHMNQAMSQAYQFVKNKRP
.|.| | . .  . |||.||. |  |.. .|.||| . . ..|  ...  ||
kfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrP
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 416-454 4e-06 20.9 In-house 216-254 (297) alignment 
Range on Protein: 416-454
Range on HMM: 216-254/297.0
AALEFIEEARRRNARVLVHCHAGISRSSTVVIAYVMKHM
  || .. .  ||| .|||| ||. ||  || . |.  .
lqleslraemprnayllvhcsaGvGrsGvvvlsdvilak