Gene DSP11 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP11
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP010_AA protein Get Run
SpurP010_AA_62-206 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP11_pd Subfamily DSP11 64-203 2.1e-68 223.7 In-house 38-177 (178) alignment
Range on Protein: 64-203
Range on HMM: 38-177/178.0
PDRFTPDDLLQKLNEMNYRMGLIIDLTATTRYYNPEIFIDRDVQYVKVFTPGHVVPPPEVVDKFTAAVSSFKEYNKDNDMIIGVHCTHGVNRTGYLVCRY
 .||||.|||.||.|.|...||.||||.|.|||... ..|..|.|.|...|||.||  |.|.||..||..|.|.|||||..|||||||||||||||.|||
ekrftpkdLleklqeknkklGLvidltntdryykkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCry

LIEREGYKPKDALKAFEEARGYPIERENYIEDLLQLSGDR
||..|||.|.||..|||||||...|||||..|| .|. |.
lidvegyepedaieafeearGhslerenylkdLkklekdk

0038934 (Phosphotyrosine protein) phosphatases II 64-218 4.6e-42 139.2 In-house 38-191 (194) alignment
Range on Protein: 64-218
Range on HMM: 38-191/194.0
PDRFTPDDLLQKLNEMNYRMGLIIDLTATTRYYNPEIFIDRDVQYVKVFTPGH-VVPPPEVVDKFTAAVSSFKeyNKDNDMIIGVHCTHGVNRTGYLVCR
  ||.|.||.. |...|...||.|||| |.|||.|| | .....|.| ..|.. .||. |....|  .|  |   |.|.. ...|||..|..|||.||..
lyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdefl..nedpggvvaVHCkaGlgRtGtlvaa

YLIEREGYKPKDALKAFEEARGYPIERENYIEDLLQLSGDRRESVRSKEFHDVYFQ
|||.| |.....|.. |.|.|.  |.. .|.|.||.  .. |..|...| ......
YLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykelrkavlapekpellle

subfamily_RNGTT_pd Subfamily RNGTT 63-212 1.1e-36 120.3 In-house 35-183 (189) alignment
Range on Protein: 63-212
Range on HMM: 35-183/189.0
IPDRFTPDDLLQKLNEMNYRMGLIIDLTATTRYYNPEIFIDRDVQYVKVFTPGHVV-PPPEVVDKFTAAVSSFKEynKDNDMIIGVHCTHGVNRTGYLVC
.  ||.|. ||. |. .....||.|||| |.|||. | . .....|||. . |. . | .| |..|   |..| .  |  . .|||||||| ||||.|..
eenrfepsmllsylktlkvklglvidltntsryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffk..knpeevigvhCthGfnRtGFliv

RYLIEREGYKPKDALKAFEEARGYPIERENYIEDLLQLSGDRRESVRSKEF
 ||.|.| .. ..|...| .||   | .|.|...||.  .| .|.. . | 
syLvekedwsveaavalFakaRppGiykedylkellrrYadveeaiaapel

0036282 (Phosphotyrosine protein) phosphatases II 71-199 2e-23 78.4 In-house 39-165 (174) alignment
Range on Protein: 71-199
Range on HMM: 39-165/174.0
DLLQKLNEMNYRMGLIIDLTATTRYYnpeiFIDRDVQYVKVFTPGHVVPPPEVVDKFTAAVSSFKEYnkDNDMIIGVHCTHGVNRTGYLVCRYLIEREGY
.... |.|.   ....|... ..|..    . . ..||... .|.| ||. .....|  .| .. .   |..  . |||..||.|||.||. ||..| ..
tvvmlleekelglykcinywpelred....lerlgiqylylpwpDhgvpdlsillefvkfveealse..dpggpvlVHCsaGvgRtGtlvaaylmlrgll

-KPKDALKAFEEAR---GYPIERENYIEDLLQL
 .. |||. . |.|   .. ........ | ..
eslvdaldlvrelRlqrpgmvqtpsQyrflyyf

0043147 (Phosphotyrosine protein) phosphatases II 64-199 2.2e-23 78.3 In-house 28-156 (172) alignment
Range on Protein: 64-199
Range on HMM: 28-156/172.0
PDRFTPDDLLQKLNEMNYRMglIIDLTatTRYYNPEIFIDRDVQYVKVFTPGHVVPPPEVVDKFTAAVSSFKeyNKDNDMIIGVHCTHGVNRTGYLVCRY
| |.| .| .. | |.. ..  |..||  ...|.|| . . ..||  .  | | ||..|....|   . ..   .....  . |||..||.|||.||. |
plrntladfwrmlkelgith..ivnlt..ellydpellerlgiqylylpwpDhgvpllellleflefidell..alspggpvlVHCsaGvgRtgtlvaay

LIErEGYKPKDALKAFEEARGYPIERENYIEDLLQL
|.. .|... .|.. . |.|.. .. ....  |...
lml.lglsleeavalvrekRpgavqnpsqyrflyyf

0041856 (Phosphotyrosine protein) phosphatases II 68-193 2.5e-22 74.8 In-house 46-160 (182) alignment
Range on Protein: 68-193
Range on HMM: 46-160/182.0
TPDDLLQKLNEMnyRMGLIIDLTatTRYYNPEIFIDRDVQYVKVFTPGHVVPPPEVVDKFTAAVSSfkeynkdNDMIIGVHCTHGVNRTGYLVCRYLIER
|. | |. | |.  . ..|..||   ..|.|| . .  .||.... |.| ||... . .|  .| .       ..  . |||..||.|||.||. ||...
tvadflrmlkel..gittivnlt..eelywpellerlgiqylylpwpDhgvpdldelldfieevle.......eggpvlVHCsaGvgRtgtlvaaylmkk

EGYKPKDALKAFEEARGYPIERENYI
 |. . .|.| . ..|   ....|..
lgvsleeavklvrsrRpgmvitpnqy

0049772 (Phosphotyrosine protein) phosphatases II 68-200 4e-22 74.8 In-house 155-270 (314) alignment
Range on Protein: 68-200
Range on HMM: 155-270/314.0
TpdDLLQKLNEMNYRmgliidltatTRYYNPEIFIDRDVQYVKVFTPGHVVPPPEVVDKFTAAVSSFkeynkDNDMIIGVHCTHGVNRTG-YLVCRYLIE
.  ...   .  ...          ...|.|| | .. ..|. . .|.. .|..| .|.| ... ..     |..  . |||..|..||| ..|. ||. 
g..neptaadlellk..........eelydpelferlgikylripvpDgsaplledfdeflefieea.....dkggpvlvHCkaGkgRtgtfvvaaylmk

REGYKPKDALKAFEEARGyPIERENYIEDLLQLS
. |. ...||. . ..|     ....|| |.|. 
llgvsleealedvrlkRp.inpnpgfieqleqye

0044763 (Phosphotyrosine protein) phosphatases II 81-198 7.5e-22 73.3 In-house 47-165 (178) alignment
Range on Protein: 81-198
Range on HMM: 47-165/178.0
YRMGLIIDLTATTRYY----NPEIFIDRDVQYVKVFTPGHVVPP-PEVVDKFTAAVSSFKEynkDNDMIIGVHCTHGVNRTGYLVCRYLIEREGYKPKDA
.  ..|..|| .....    .|. . . ..||... .|.| ||. .| ...|.... .. .   ...  . |||..||.|.|.||. ||. . |. . .|
lgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeald...ekggpvlVHCsaGvgRsgtlvaaylmkklglsleea

LKAFEEARGyPIERENYIEDLLQ
.. . |.|   ........ |..
ielvrerRp.ivpnpgqlrqLye

0049260 (Phosphotyrosine protein) phosphatases II 78-199 1.3e-21 72.3 In-house 27-145 (152) alignment
Range on Protein: 78-199
Range on HMM: 27-145/152.0
EMNYRMGLIIDLTATTRYYNPEIFIDRDVQYVKVFTPGHVVPPPEVVDKFTAAVSSFKeyNKDNDMIIGVHCTHGVNRTGYLVCRYLIErEGYKPKDALK
.| ...|  . .. |......... ..  ||  ...| | ||. . . .|   .  .   ..|..  . |||..||.||| ||. ||..  |.....|..
rmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml.lgvsleeava

AFEEARGYPIERENYIEDLLQL
 . |.| . .. ..... |.. 
lvrekRpgavpnpgqlrflyef

0048179 (Phosphotyrosine protein) phosphatases II 79-199 2e-20 68.4 In-house 26-140 (144) alignment
Range on Protein: 79-199
Range on HMM: 26-140/144.0
MNYRMGLIIDLTATtryYNPEIFIDRDVQYVKVFTPGHVVPPP-EVVDKFTAAVSSFKEynkdNDMIIGVHCTHGVNRTGYLVCRYLIEREGYKPKDALK
 ..  ...|.|| .   | || ...  .||... .|.| ||.  | ...| ... .. |    ..  . |||..||.|||.||. ||. ..|. ...||.
kklgittvinltee...yepefleregiqylhlpwpDhgvpdllellleflefieeale....eggpvlVHCsaGvgRtgtlvaaylmkklglsleeala

AFEEARGYPIERENYIEDLLQL
 . ..| . .. ..... ||..
lvrsrrpgavpnpgqlrfLley

0048076 (Phosphotyrosine protein) phosphatases II 79-198 7.1e-20 66.6 In-house 26-137 (145) alignment
Range on Protein: 79-198
Range on HMM: 26-137/145.0
MNYRMGLIIDLtattrYYNPEIFIDRDVQYVKVFTPGHVVPPP-EVVDKFTAAVSSFKEynkdNDMIIGVHCTHGVNRTGYLVCRYLIEREGYKPKDALK
 ..  .....|      ...| . . ..||. . .|.| ||.  | ...| ... .. .    ..  . |||..||.|||.||. ||. ..|. . .||.
kdlgittvlnl.....tselellerlgiqylylpwpDhgvpdllellleflefieealk....eggpvlVHCsaGvgRtgtlvaaylmlllgvsleeale

AFEEARGYPIERENYIEDLLQ
 . ..| . ........ |..
lvrsqrpgavpnpgqlrflye

PTEN_1 73-185 3.1e-19 64.6 In-house 56-173 (196) alignment
Range on Protein: 73-185
Range on HMM: 56-173/196.0
LQKLNEMNYRMG--LIIDLTATT----RYYNPEIFIDRDVQYVKVFTPGHVVPPPEvvdKFTAAVSSFKEYNKD--NDMIIGVHCTHGVNRTGYLVCRYL
.... .... .|  |...|.       | |..|.|....|.| ..  . | .|. .   .. ... ||.|. .   |  .. |||..|..|.| .|. ||
vaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapsls...elfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayL

IEREGYKPKDALKAFEEARGY
...... ...||. . |.|  
mykgkltadeAlelvrekRpp

0037934 (Phosphotyrosine protein) phosphatases II 80-198 3.7e-19 64.7 In-house 70-236 (243) alignment
Range on Protein: 80-198
Range on HMM: 70-236/243.0
NYRMGLIIDLTATT----------------------------------------RYYNPEIFIDRDVQYVKVFTPGHVVPP-PEVVDKFTAAVSSFKEY-
... . |..|| ..                                        ...... .   ...|  .  |.| ||. || . .|  .| .| |  
elgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieel

----NKDNDMIIGVHCTHGVNRTGYLVCRYLIERE-GYKPKDALKAFEEARGY-PIERENYIEDLLQ
    . |..  . |||..||.|||.|.. ||. .  |. . .|.| . | |..  .. ..... | .
lsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflye

0040439 (Phosphotyrosine protein) phosphatases II 68-198 7.7e-19 63.7 In-house 66-240 (249) alignment
Range on Protein: 68-198
Range on HMM: 66-240/249.0
TPDDLLQKLNEMNyrMGLIIDLTATTRY-------------------------------------------YNPEIFIDRDVQYVKVFtPGHVVPPPEVV
| .| .. | | .   . |..|| ....                                           |..| .  . .||..     .| | .| .
tvedfwrmlwelg..itvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp.dhgvppsfedl

DKFTAAVSSFKEYNkDNDMIIGVHCTHGVNRTGYLVCRYLI-----EREGYKPKDALKAFEEARGYPIERENYIEDLLQ
..|  || .. |.. ...  . |||..||.|||.... ||.     .. |. ...|.| . ..|.. .. ..... |..
ldfieavrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflye

0042113 (Phosphotyrosine protein) phosphatases II 68-197 3.3e-18 61.4 In-house 64-236 (245) alignment
Range on Protein: 68-197
Range on HMM: 64-236/245.0
TPDDLLQKLNEMNyrMGLIIDLTATTRYYN-----------------------------------------PEIFIDRDVQYVKVFTPGHVVPP-PEVVD
|..| .. | | .     |..|| .. .                                           .. .   ...|  .  |.| ||. .| ..
tvedfwrmlwelg..ittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllelll

KFTAAVSSFKEYnkDNDMIIGVHCTHGVNRTGYLVCRYLI-----EREGYKPKDALKAFEEARGYPIERENYIEDLL
.|  .| .. .   |..  . |||..||.|||.... ||.     .. |. . .|.| . . |.  .. ..... | 
dflefvrkalae..dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrfly

0046846 (Phosphotyrosine protein) phosphatases II 63-195 1.1e-17 59.9 In-house 30-164 (176) alignment
Range on Protein: 63-195
Range on HMM: 30-164/176.0
IPDRFTPDDLLQKLNEMnyRMGLIIDLTATT-------RYYNPEiFIDRDVQYVKVFTPGHVVPPPEVVDKFTAAVSSFKEYNkdndMIIGVHCTHGVNR
 | . |  | |. | |.  . .....||  .        .| || . . ..||  . .| | ||. | .... ... .. . .      . ||| .|..|
gplprtladflemlkel..gitavvnlteevelgrlkcpnywpe.leklgiqylhlpwpDhgvpdlelllellefirealkeg....gpvlVHCsaGigR

TGYLVCRYLIER-EGYKPKDALKAFEEARG-YPIERENYIED
|| ||. ||.|.  |... .||. . | |  . .. ..... 
tgtlvaayllelekglsveealalvreqRplgavqtpeQyrf

0040438 (Phosphotyrosine protein) phosphatases II 80-198 3.3e-17 58.2 In-house 108-270 (317) alignment
Range on Protein: 80-198
Range on HMM: 108-270/317.0
NYRMGLIIDLTATTRY----------------------YNPEIFIDRDVQYVKVFT-------------------PGHVVPP-PEVVDKFTAAVSSFKEy
... ..|. || .. .                       . ... . .... ..                     | | ||| |. . .|  || .. | 
eqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.

nkDNDMIIGVHCTHGVNRTGYLVCRYLI-----EREGYKPKDALKAFEEARGYPIERENYIEDLLQ
  |..  . |||..||.|||.... ||.     ...|. ...|.| . |.|.. .. ..... | .
..dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyd

0051082 (Phosphotyrosine protein) phosphatases II 73-190 8.8e-17 56.6 In-house 26-139 (151) alignment
Range on Protein: 73-190
Range on HMM: 26-139/151.0
LQKLneMNYRMGLIIDLTATT-RYYNPEIFIDRDVQYVKVFTPGHVVPPpeVVDKFTAAVSSFKEYNKDNDMIIGVHCTHGVNRTGYLVCRYLIErEGYK
|. |   ..    |..|. .. |.|.||.. . ..... .  ... .|.  . . | |... .........  . |||..|..||| ||. ||.  .|. 
lell..kelgiktivnlrseeergycpeylpelgievlhipildwpdpg..lplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylml.lgvs

PKDALKAFEEARGYPIERE
. .||. . . |.. .  .
leealeeyrlkrpgvvqpn

0045450 (Phosphotyrosine protein) phosphatases II 82-198 1e-15 53.7 In-house 131-298 (307) alignment
Range on Protein: 82-198
Range on HMM: 131-298/307.0
RMGLIIDLTATTRY---------------------------------------------YNPEIFIDRDVQYvkVFTPGHVVPP-PEVVDKFTAAVSSFK
. ..|..|| .. .                                             .. | .. .  .|     |.| ||| .| . .|  .| .. 
gvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhy..tgwpdhgvppsfeelldfieevrkal

EYNkDNDMIIGVHCTHGVNRTGYLVCRYLIEREG--------YKPKDALKAFEEARGYPIERENYIEDLLQ
| . ...  . |||..||.|||.... ||. | .        . . .|.| . | |.  .. ..... | .
eel.pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflye

0043336 (Phosphotyrosine protein) phosphatases II 81-195 1.7e-15 52.7 In-house 154-268 (278) alignment
Range on Protein: 81-195
Range on HMM: 154-268/278.0
YRMGLIIDLTATTRyYNPEIFIDRDVQYVKVFtpGHVVP-PPEVVDKFTAAVSSFKEynkDNDMIIGVHCTHGVNRTGYLVCRYLI-----EREGYKPKD
.    ...|. | . ...| .. . ..|...    | || ... . .|  || .. |   |..  . |||..||.|||.... ||.      . |. . .
lddytvrtlevtnl.gdgesrtvthyhylgwp..dhgvpeslsllldflkavreale...dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdlee

ALKAFEEARGYPIERENYIED
|.| . | |.  .. ..... 
avkelreqRpgavqtpsqyrf

0045098 (Phosphotyrosine protein) phosphatases II 76-187 8.2e-15 50.4 In-house 126-255 (278) alignment
Range on Protein: 76-187
Range on HMM: 126-255/278.0
LNEMNYRMGLIIDLTATTRYYNPEIFIDRDVQYVKV-FTPGHVVPPPEVVDKFTAAVSSFKEYNK-------------DNDMIIGVHCTHGVNRTGYLVC
|.|... .  ...|. |  ....| .  | |....  . | | ||. .... |  ..   .|..|             |..  . ||| .||.||| ||.
lseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlva

RYLIERE---GYKPKDALKAFEEARGY-PI
 ||. .    |. . .|.| . . |..  .
aylmlelleggvdlleavkelrsqRpglav

0039614 (Phosphotyrosine protein) phosphatases II 82-196 1.2e-14 50.0 In-house 125-281 (297) alignment
Range on Protein: 82-196
Range on HMM: 125-281/297.0
RMGLIIDLTATTRY--------------------YNPEIFIDRDVQ-----------------YVKVFTPGHVVPP-PEVVDKFTAAVSSFKEYNkDNDM
.   |. || .. .                    .. ... . ..                  .  .  | | ||| .|....|  .| .. ... ... 
gvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealael.pkgg

IIGVHCTHGVNRTGYLVCRYLI-----EREGYKPKDALKAFEEARGYPIERENYIEDL
 . |||..||.|||.... ||.     .. |. ...|.| . |.|.. .. ..... |
pvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrfl

DSPc Dual specificity phosphatase, catalytic domain 123-199 3.1e-14 48.0 Pfam-A 55-130 (133) alignment
Range on Protein: 123-199
Range on HMM: 55-130/133.0
VVDKFTAAVSSFKEYnKDNDMIIGVHCTHGVNRTGYLVCRYLIEREGYKPKDALKAFEEARGYPIERENYIEDLLQL
..... .||.  ..  ...   . |||..|..|...|...||....... ..|.....| |.   ......  ||..
iskeleeavefieka.eqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerrskispnagflrqLley

DSPc Dual specificity phosphatase, catalytic domain 123-199 3.1e-14 48.0 In-house 55-130 (133) alignment
Range on Protein: 123-199
Range on HMM: 55-130/133.0
VVDKFTAAVSSFKEYnKDNDMIIGVHCTHGVNRTGYLVCRYLIEREGYKPKDALKAFEEARGYPIERENYIEDLLQL
..... .||.  ..  ...   . |||..|..|...|...||....... ..|.....| |.   ......  ||..
iskeleeavefieka.eqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerrskispnagflrqLley

0048567 (Phosphotyrosine protein) phosphatases II 89-183 8.3e-13 43.0 In-house 21-118 (157) alignment
Range on Protein: 89-183
Range on HMM: 21-118/157.0
LTATTRYYNPEIF-IDRDVQYVKVFTPGHvVPPPEVVDKFTAAVSSFKEYNKDNDMIIGVHCTHGV---NRTGYLVCRYLIEREGYKPKDALKAFEEAR
  .....||. .| ||....|.  | .    ..  .. .|   . .| .. . ..  | |||..|     ||..|.. ||| . |. | .|.. .  .|
prlpkslynalyFsiddglvyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivr

PTPc_motif_SM00404 130-199 1.2e-12 42.9 In-house 72-137 (140) alignment
Range on Protein: 130-199
Range on HMM: 72-137/140.0
AVSSFkeynKDNDMIIGVHCTHGVNRTGYLVCRYLIEREGYKPKDALKAFEEARGYPIERENYIEDLLQL
 ....    ...   . |||..||.|...|.. ||....... ..|.....| |    ...|... |...
fiena....ekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeayefvkerRpiispnlnfvrqLiey

0046845 (Phosphotyrosine protein) phosphatases II 77-191 1.5e-11 39.7 In-house 141-261 (284) alignment
Range on Protein: 77-191
Range on HMM: 141-261/284.0
NEMNYRMGLIIDLTATTRYYNPEIFIDRDVQYVKVFtpGHVVPP-PEVVDKFTAAVSSFKEYnKDNDMIIGVHCTHGVNRTGYLVCRYLIERE-------
.|...    .. |. |   |. | .. .  .| .     | ||| || . .|  .| .. |   ...  | ||| .||.|||.... .|. .        
seevkddytvrtleltnlgytgesrtvthfhytswp..dhgvppspedlleflrlvrellen.lpgggpivVHCsaGvgRtGtfialdllleqlekegll

-GYKPKDALKAFEEARGYPIEREN
 |. . .|.| . | | . .. . 
lgvdvleavkrlreqRpgmvqtle

0051429 (Phosphotyrosine protein) phosphatases II 68-209 2.4e-11 39.3 In-house 34-269 (272) alignment
Range on Protein: 68-209
Range on HMM: 34-269/272.0
TPDDLLQKlneMNYRMGLIIDLTATT-RYYNPEIFIDRDVQYVKVFTPGHVVPPPE--------------------------------------------
|..|. .     ...   |.||. .. | ...  .   ...|. . ......|...                                            
taadfwrl...kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdw

--------VVDKFTAAVSSfkeynkdnDMIIGVHCTHGVNRTGYLVCRYLIErEGYK--------------PKDALKAFEEARGYPIE------------
         . .. ... .        .  . |||..|..||| .|. .|.  .|                . .|..   ..| . ..            
pdhgvpqeallellellld........ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeal

----------------------------RENYIEDlLQLSGDRRESVRS
                             |.|..| |.|| . .| .|.
lellrsllsvraeyllaaldaideeyGsvegYLrd.lglseeelerLre

subfamily_VSP_pd Subfamily VSP 91-184 4.7e-11 37.0 In-house 82-171 (212) alignment
Range on Protein: 91-184
Range on HMM: 82-171/212.0
ATTRYYNPEIFIDRdVqyVKVFTPGHVVPPPEVVDKFTAAVSSFKeyNKDNDMIIGVHCTHGVNRTGYLVCRYLIEREGYK-PKDALKAFEEARG
 . | |....| .| |  ... .  | ||  | . .||  |  .   .||.. .. .||  | .||| .|| .|.. | ..  |..|. | | | 
cseraydekyfnnr.v..kriliddhnvpkleellvftkevkewl..ekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrt

subfamily_PTEN_pd Subfamily PTEN 71-183 1.2e-10 36.6 In-house 49-156 (184) alignment
Range on Protein: 71-183
Range on HMM: 49-156/184.0
DLLQKLNEMNYRMGLIIDLTAtTRYYNPEIFiDRDVQYVKVftPGHVVPPPEVVDKFTAAVSSFKEynKDNDMIIGVHCTHGVNRTGYLVCRYLIEREGY
|. . |..       |..|..  |.|. . | |  |. ...    |  || |.....   .... |  .|.. .. |||  |  ||| |.. ||...  .
dvvkflekkhkdhykiynlrs.erkydskkf.dgrvavypf..dDhnppplelleeivediekwle..edkknvvvvHCkaGkGRtGvlivayllkslll

KPK-DALKAFEEAR
. . .||. |.|||
ekaeealelfaeaR

0050432 (Phosphotyrosine protein) phosphatases II 108-190 4.1e-10 34.9 In-house 202-285 (308) alignment
Range on Protein: 108-190
Range on HMM: 202-285/308.0
YVKVFTPGHVVPP-PEVVDKFTAAVSSFKeynkdNDMIIGVHCTHGVNRTGYLVCRYLI-----EREGYKPKDALKAFEEARGYPIERE
.     | | ||| || . .|  .| ..      ..  | ||| .||.||| ... .|.     .  |  . .|.| . | | . .. .
fhytnWpdhgvPpspeilldflelvrksl.....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp

subfamily_PRL_pd Subfamily PRL 95-185 7.9e-10 33.0 In-house 45-132 (151) alignment
Range on Protein: 95-185
Range on HMM: 45-132/151.0
YYNPEIFIDRDVQYVKVFTPGHVVPPPEVVDKFTAAVSsfKEYNKDNDMIIGVHCTHGVNRTGYLVCRYLIErEGYKPKDALKAFEEARGY
 |. | . ..... . .      ||| |||... . .   ........ ...|||  |. |.  ||.  ||| .| |..||..   | |  
tydteklekegievldlafddGavPpeevveeWlellk..ekfkeepkstvavhcvaGlGraPvlvalalie.aGmkyedavefirekrrg

0047943 (Phosphotyrosine protein) phosphatases II 106-191 8.2e-10 34.1 In-house 171-259 (273) alignment
Range on Protein: 106-191
Range on HMM: 171-259/273.0
VQYVKVFtpGHVVP-PPEVVDKFTAAVSSFKEYNKDNdMIIGVHCTHGVNRTGYLVCRYLI-----EREGYKPKDALKAFEEARGYPIEREN
..| .     | ||  .| . .|  .| .. |....|   . ||| .||.||| ... .|.     .. |  ...|.| . . | . .. ..
fhytgwp..dhgvppslesllefielvrkalealpsn.gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpe

0051299 (Phosphotyrosine protein) phosphatases II 108-190 2.4e-09 32.5 In-house 187-272 (288) alignment
Range on Protein: 108-190
Range on HMM: 187-272/288.0
YVKVFTPGHVVPP-PEVVDKFTAAVSSFKEynkDNDMIIGVHCTHGVNRTGYLVCRYLI-----EREGYKPKDALKAFEEARGYPIERE
.     | | ||. || . .|  .| .. .   ...  . ||| .||.||| ... .|.     ...|  . .|.| . | | . .. .
fhytnwpdhgvpdspellldflrlvrkala...sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp

PTPc_DSPc_SM00012 114-173 9.7e-09 30.7 In-house 11-70 (105) alignment
Range on Protein: 114-173
Range on HMM: 11-70/105.0
PGHVVPPPEvvDKFTAAVSSFKEYNKDND--MIIGVHCTHGVNRTGYLVCRYLIEREGYKPK
| | || .   |... .. ..|. .....    . ||| .||.|||..|. ... .  .| .
pdhgvPees..dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket

0036941 (Phosphotyrosine protein) phosphatases II 111-190 1.2e-08 30.1 In-house 176-263 (297) alignment
Range on Protein: 111-190
Range on HMM: 176-263/297.0
VFTPGHVVPP-PEVVDKFTAAVSSFKEYNKDNdMIIGVHCTHGVNRTGYLVCRYLI--------EREGYKPKDALKAFEEARGYPIERE
   | | ||. |. . .|  .| .. ..  ..   . ||| .||.|.| ... .|.        ...|. ...|.| . | |   .. .
tgwpdhgvpespaslldfielvrkvlkllpsg.gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtl

subfamily_DSP23_pd Subfamily DSP23 89-188 2.3e-08 28.8 In-house 35-130 (148) alignment
Range on Protein: 89-188
Range on HMM: 35-130/148.0
LTATTRYYNPEIFIDRDVQYVKVFTPGHVVPPPEVVDKFTAAVssfKEYNKDNDmIIGVHCTHGVNRTGYLVCRYLIEREGYKPKDALKAFEEARGYPIE
| . |   .|..    .. .|..  . .  | .| |..|   |   .| .. |.  ..|||  |  ||| ..  ||.  ..    .|.    . |   .|
lvslteegrphveatpnltlvrlriddyhppaleqvvefvrvv...eeaeekne.avsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpgsve





subfamily_PTPDC1_pd Subfamily PTPDC1 96-196 2e-07 25.6 In-house 73-168 (182) alignment
Range on Protein: 96-196
Range on HMM: 73-168/182.0
YNPEIFIDRDVQYVKVFTPGHVVPPPEVVDKFTAAVSSfkeyNKDNDmIIGVHCTHGVNRTGYLVCRYLIEREGYKPKDALKAFEEARGYPIERENYIED
|..| . .... . ..  . . |.. | .      |..      ...  ..|||  |  ||| |.. ||.  . .....|.|   . |   |.  . .| 
YdlealmeqgiyvynfgwkDygvasleriLdivkvvaf....alqeg.kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvel

L
.
v

subfamily_PTPMT1_pd Subfamily PTPMT1 105-185 6e-07 24.1 In-house 73-150 (171) alignment
Range on Protein: 105-185
Range on HMM: 73-150/171.0
DVQYVKVFTPGHVVPPPevVDKFTAAVSSFKEYNKDNDMiIGVHCTHGVNRTGYLVCRYLIEREGYKPKDALKAFEEARGY
.|..... |. .   |   ..| . .|   ... .. .  . |||  |  |.. ||  ||. .|  .|..|||| .. | .
gveqlqlatvDfteapd..leklekgvefiekvaskgkr.vYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRki

subfamily_CDC14_pd Subfamily CDC14 68-169 6.1e-07 23.6 In-house 200-290 (328) alignment
Range on Protein: 68-169
Range on HMM: 200-290/328.0
TPDDLLQKLNEMNyrMGLIIDLTATtrYYNPEIFIDRDVQYVKVFTPGHVVPPPEVVDKFTAAVSSFkeynkdnDMIIGVHCTHGVNRTGYLVCRYLIER
.|. ||.  .. |  .  .. | .    |. . | |  .... .|     .|. ..| ||.... .        .  | |||  |. ||| |.  ||...
aPeklleyfrknn..vttvvrLnkk..lYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka.......eGaiavhCkaGLGrtGtLiacylmkh

EG
 .
yr

subfamily_DSP10_pd Subfamily DSP10 81-194 1.4e-06 22.3 In-house 38-144 (159) alignment
Range on Protein: 81-194
Range on HMM: 38-144/159.0
YRMGLIIDLTATTryynPEIFIDRDVQYVKVftPGHVVPPPEVVDKFTAAVSSFKEYNKDNDMIIgVHCTHGVNRTGYLVCRYLIEREGYKPKDALKAFE
...  ....|...    |  | . ...| ..  | .     ..  .|..|.   .| .| .  .. |||  |. |   .|  ||... . . .|| |  .
lnitavlnvttsv....PnefeeealkYkri..pvsDtskqnlkqyfeealefieearkkgsrvL.vhCqaGisrsatvviaYlmkhlnlslndaykfvk

EARGYPIERENYIE
|.|       |.. 
ekrpiisPnLnfmG

subfamily_DSP12_pd Subfamily DSP12 133-193 4.1e-06 21.3 In-house 73-133 (155) alignment
Range on Protein: 133-193
Range on HMM: 73-133/155.0
SFKEYNKDNDMIIGVHCTHGVNRTGYLVCRYLIEREGYKPKDALKAFEEARGYPIERENYI
.| |   ...  . |||. || |   .|  ||. .|. . ..|||. .|..      |...
dFieealeeegavlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkpeiepNegFl

subfamily_DSP19_pd Subfamily DSP19 126-183 4.7e-06 21.0 In-house 73-130 (152) alignment
Range on Protein: 126-183
Range on HMM: 73-130/152.0
KFTAAVSSFKEYNKDNDMIIGVHCTHGVNRTGYLVCRYLIEREGYKPKDALKAFEEAR
..  ..  | |  ...| .. |||  || |.  .|  ||...|  . ..||.   |||
sylkealdFieearskdgavlvHCnAGvSRsasvviaylmkkeelsleealelvrear