Gene DSP12 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP12
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP011_AA protein Get Run
SpurP011_AA_2-150 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP12_pd Subfamily DSP12 6-158 2.1e-57 187.9 In-house 3-155 (155) alignment 
Range on Protein: 6-158
Range on HMM: 3-155/155.0
DEILPRLWLGDLQAAESERFLNDRKISHVLSLINMPI--TVPSEVAVNHKQIIIRDQPGEDLLTHLEDILAFMEDGLdpAKEGSVLVHCAMGVSRSSSAV
..|||.|.||.|.|...|..|.. ||.||||.|....    ...  |..|.| |.|.| ||.|.||.....|.|..|  ..||.|||||..|||||...|
srilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieeal..eeegavlvHCqagvSRSvtiv

IAYIMYKEKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFEAMGCQCDTTNSQFKQ
|||.|.|||..| .|||.| .|.....||.||.|||||||.|||..||.|...|.
iAYlmkkeklslekAlklvkekkpeiepNegFleQLklfekmgckvdtsnkayke
subfamily_DSP19_pd Subfamily DSP19 7-144 2e-33 109.9 In-house 14-148 (152) alignment 
Range on Protein: 7-144
Range on HMM: 14-148/152.0
EILPRLWLGDLQAAESERFLNDRKISHVLSLI-NMPITVPSEVavNHKQIIIRDQPGEDLLTHLEDILAFMEDGLDpaKEGSVLVHCAMGVSRSSSAVIA
|. |||.||  ..|.... |. .|| |.|..  ..| . |...  . ..| | |.| .|||..|...| |.|....  |.| |||||  |||||.| |||
eveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdf..tylsieilDlpetdllsylkealdFieears..kdgavlvHCnAGvSRsasvvia

YIMYKEKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFEA
|.| ||.  | .||..| ...   .||.||..||| .||
ylmkkeelsleealelvrearpcikPneGFikqLkeyea
0044763 (Phosphotyrosine protein) phosphatases II 3-148 1.3e-31 105.0 In-house 21-172 (178) alignment 
Range on Protein: 3-148
Range on HMM: 21-172/178.0
GYADEILPRLWLGDLQAAESERFLNDRKISHVLSLINM--------PITVPSEVAVNHKQIIIRDQPGEDLLTHLEDILAFMEDGLDpAKEGSVLVHCAM
 .|.||||.|.||.| .|.  ..| . .|.|...| .         .   |.|  .....| | | .  ||| |......|.|. ||  |.| ||||| .
inaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsa

GVSRSSSAVIAYIMYKEKCPLVTALKKVVDKHSqTCPNTGFMEQLKLFEAMGCQ
||.|| . |.||.|.| ...|  |.. |  . .  .|| |...||..|| . ..
GvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllk
PTPc_motif_SM00404 7-144 1.6e-29 97.6 In-house 4-139 (140) alignment 
Range on Protein: 7-144
Range on HMM: 4-139/140.0
EILPRLWLGDLQAAESERFLNDRKISHVLSLIN-MPITvPSEVAVNHKQIIIRDQPGEDLLTHLEDILAFMEDGldPAKEGSVLVHCAMGVSRSSSAVIA
.|||.|.|| ...|.....|.  .|.||..... ...|  ..  ....|| ..|.  ..|. .|. .|.|.|.    .|.|.|||||..||||| . .||
rilphlylgskskaqnpallkklgithvinvteevslt.kensgfqilqiplddnekdklskyldkvldfiena..ekkggkvlVHCqaGvSRSatliia

YIMYKEKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFEA
|.|..... |  |.. | .. .. .||..|..||  .| 
YlmryrqlslaeayefvkerRpiispnlnfvrqLieyek
subfamily_DSP1_pd Subfamily DSP1 7-144 8.4e-29 94.7 In-house 20-154 (163) alignment 
Range on Protein: 7-144
Range on HMM: 20-154/163.0
EILPRLWLGDLQAAESERFLNDRKISHVLSLINMpITVPSEVAVNHKQIIIRDQPGEDLLTHLEDILAFMEDGLdpAKEGSVLVHCAMGVSRSSSAVIAY
.||. |.||  . |   ..|.. .|...| . .. .    |   ..|.. ..|.| .|. ...|... |...    .|.| ||.||..|.||||. ..||
kildfLylGsetvasnleiLkslgitailnvske.ldnvfedlfeYkklkleDspkadislvfeeviefidevk..kknGkvlihCqaGisRsstlclay

IMYKEKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFEA
.| .... |  | . | .. |   ||.||. ||. .| 
lmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyek
0048076 (Phosphotyrosine protein) phosphatases II 2-145 8.6e-29 95.4 In-house 1-141 (145) alignment 
Range on Protein: 2-145
Range on HMM: 1-141/145.0
PGYADEILPRLWLGDLQAAESERFLNDRKISHVLSLINMPiTVPSEVAVNHKQIIIRDQPGEDLLTHLEDILAFMEDGLDPAkeGSVLVHCAMGVSRSSS
|....||||.|.||.| .|.. ..| | .| .||.| ... . ...  ... .. . | .  ||| .|...|.|.|. |.    | ||||| .||.|. .
pywpseilpglylgslptaldlellkdlgittvlnltsel.ellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgt

AVIAYIMYKEKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFEAM
 |.||.|......|  ||..|  .... .|| |....|..|| .
lvaaylmlllgvsleealelvrsqrpgavpnpgqlrflyefele
subfamily_LRR-DSP_pd Subfamily LRR-DSP 6-144 1.4e-28 93.7 In-house 121-256 (263) alignment 
Range on Protein: 6-144
Range on HMM: 121-256/263.0
DEILPRLWLGDLQAAESERFLNDRKISHV-LSLINMPITVPSEVavNHKQI-IIRDQPGEDLLTHLEDILAFMEDGldpAKEGSVLVHCAMGVSRSSSAV
|||...|.|| |..|  . .|.|  ..|. |.. ..    |      .  |  |.| .  |.  |.|.. ||.|.|    |.| |||||  ||||||..|
deiidklflGgldsannksilkdlgvthillavadfePlfPklf..kylsiddiedvdeadisqhfeetnafieeG...rkkGGvlvhcraGvsrsstlv

IAYIMYKEKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFEA
|.|.| |..  .  ||  |. | ..  ||.||..||| .|.
isylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyek
0048179 (Phosphotyrosine protein) phosphatases II 3-144 6.3e-28 92.7 In-house 2-142 (144) alignment 
Range on Protein: 3-144
Range on HMM: 2-142/144.0
GYADEILPRLWLGDLQAAESERFLNDRKISHVLSLINMPITVPSEVA-VNHKQIIIRDQPGEDLLTHLEDILAFMEDGLDpaKEGSVLVHCAMGVSRSSS
.. .||||.|.||.| .|..  .| . .|..|..|..       |.  ... .. . | .  |||..|...|.|.|. |.  ..| ||||| .||.|. .
snpseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgt

AVIAYIMYKEKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFEA
 |.||.|.|....|  ||. |  .... .|| |....|...| 
lvaaylmkklglsleealalvrsrrpgavpnpgqlrfLleyek
subfamily_DSP6_pd Subfamily DSP6 7-144 1.7e-27 89.9 In-house 16-152 (158) alignment 
Range on Protein: 7-144
Range on HMM: 16-152/158.0
EILPRLWLGDLQAAESERFLNDRKISHVLSLI-NMPITVPSEVAVNHKQIIIRDQPGEDLLTHLEDILAFMEDGLDpaKEGSVLVHCAMGVSRSSSAVIA
||||.|.||  ..|.    |.. ||..|| .  |.| .  ..  ....|| |.|.  ..| ... . ..|....    |. .|||||  |.|||   ..|
eilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidears..kkskvlvhClaGisrsvtvtla

YIMYKEKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFEA
|.| |... |  | . | ...|.  ||  ||.||. || 
ylmkklalslndaydlvkkrksnisPnfnfmgqlldfer
subfamily_DSP10_pd Subfamily DSP10 7-144 2.5e-27 89.7 In-house 16-151 (159) alignment 
Range on Protein: 7-144
Range on HMM: 16-151/159.0
EILPRLWLGDLQAAESERFLNDRKISHVLSLINMPITVPSEVAVNHKQIIIRDQPGEDLLTHLEDILAFMEDGLdpAKEGSVLVHCAMGVSRSSSAVIAY
..|| |.||. . |...  |.  .|..|| . .   .  .| |...|.| ..|.  ..| .. |. |.|.|.     |. .|||||  |.|||.. ||||
qvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieear..kkgsrvLvhCqaGisrsatvviaY

IMYKEKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFEA
.|.. .  |  | | | .| .   || .|| ||. || 
lmkhlnlslndaykfvkekrpiisPnLnfmGqLlefek
subfamily_DSP14_pd Subfamily DSP14 7-144 3.2e-27 89.4 In-house 9-142 (157) alignment 
Range on Protein: 7-144
Range on HMM: 9-142/157.0
EILPRLWLGdLQAAESERFLNDRKISHVLSLINMPITvPSEVAVNHKQIIIRDQPGEDLLTHLEDILAFMEDGldPAKEGSVLVHCAMGVSRSSSAVIAY
.| | |.|.  .|| |.. |. .||.... ..    . ..   ... .. ..|.| ..| .|.. . . .|.    .|.| .||||..||||| | ..||
qitpsLfls.gvaalskellkkkkitliinvtvelpn.tklkdiervkvpveDnpeaklakhfdevadkieev..kkkggktlvhCvaGvSRSAslclay

IMYKEKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFEA
.|  ||  |  | | | .. .. .||.|| .||  .| 
lmkyeklsLreayklvksaRpiirPNvGFwkqlidyEk
subfamily_DSP3_pd Subfamily DSP3 5-142 7.6e-26 84.7 In-house 11-153 (162) alignment 
Range on Protein: 5-142
Range on HMM: 11-153/162.0
ADEILPRLWLGDLQAAESERFLNDRKISHVLSLINMPI-------TVPSEVAVNHKQIIIRDQPGEDLLTHLEDILAFMEDGLDPaKEGSVLVHCAMGVS
.||. |.|..|| ..|. .. |.   | |||   .  .          ... ...  . ..|.|  || .. |   .|... |.  ||| |||||..|||
vdevypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsq.kegkvlvhcvvGvs

RSSSAVIAYIMYKEKCPLVTALKKVvDKHSQTCPNTGFMEQLKLF
||.  |.||.| ..|  || |...|  |. . .||.||..||. .
RsatlvlayLmirrkmtlveairtv.rkkReilPneGFlkqLael
subfamily_DSP15_pd Subfamily DSP15 6-146 3.4e-25 82.9 In-house 3-139 (151) alignment 
Range on Protein: 6-146
Range on HMM: 3-139/151.0
DEILPRLWLGDLQAAESERFLNDRKISHVLSLINMPITVPSEvaVNHKQIIIRDQPGEDLLTHLEDILAFMEDGldPAKEGSVLVHCAMGVSRSSSAVIA
...|| |.||... .. |  |....|.|.||. . .  .  .  ...| | . | |. .| .....   |. .     ||..|||||..|||||   |.|
skvlpglylgnfrdskdeelLkeknithilsvhdnakkllkd..ieYkciaasDtpsaklskffkesvefihkc..RlkeenvlvhClaGvsRsvtlvva

YIMYKEKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFEAMG
|.|   .     ||. .  . |   ||.|| .||| .| . 
YlmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyektk
0049772 (Phosphotyrosine protein) phosphatases II 49-145 4e-25 84.6 In-house 180-272 (314) alignment 
Range on Protein: 49-145
Range on HMM: 180-272/314.0
AVNHKQIIIRDqPGEDLLTHLEDILAFMEDGldpAKEGSVLVHCAMGVSRSSS-AVIAYIMYKEKCPLVTALKKVVDKHSqTCPNTGFMEQLKLFEAM
 .....| . | ....|| .....|.|.|.     |.| |||||..|..|. . .|.||.|.. ...| .||. |  |..  .|| ||.|||...| .
gikylripvpD.gsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefi
DSPc Dual specificity phosphatase, catalytic domain 12-143 1.5e-24 81.3 Pfam-A 1-131 (133) alignment 
Range on Protein: 12-143
Range on HMM: 1-131/133.0
LWLGDLQAAEsERFLNDRKISHVLSLI-NMPI-TVPSEVAVNHKQIIIRDQPGEDLLTHLEDILAFMEDGldPAKEGSVLVHCAMGVSRSSSAVIAYIMY
|.||  ..|. ...|.. .|..|.... ..|     ..   .. .| ..|.  ...  .||.. .|.|.    .|...|||||..|.||| . .|||.|.
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefieka..eqkgkkvlVHCqaGisRSatliiaYlmk

KEKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFE
.....|  |.. | .. |. .||.||. ||  .|
tknlslneAyefvkerrskispnagflrqLleye
DSPc Dual specificity phosphatase, catalytic domain 12-143 1.5e-24 81.3 In-house 1-131 (133) alignment 
Range on Protein: 12-143
Range on HMM: 1-131/133.0
LWLGDLQAAEsERFLNDRKISHVLSLI-NMPI-TVPSEVAVNHKQIIIRDQPGEDLLTHLEDILAFMEDGldPAKEGSVLVHCAMGVSRSSSAVIAYIMY
|.||  ..|. ...|.. .|..|.... ..|     ..   .. .| ..|.  ...  .||.. .|.|.    .|...|||||..|.||| . .|||.|.
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefieka..eqkgkkvlVHCqaGisRSatliiaYlmk

KEKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFE
.....|  |.. | .. |. .||.||. ||  .|
tknlslneAyefvkerrskispnagflrqLleye
0041856 (Phosphotyrosine protein) phosphatases II 5-150 2e-24 81.6 In-house 19-176 (182) alignment 
Range on Protein: 5-150
Range on HMM: 19-176/182.0
ADEILPRLWLGDLQA--------------AESERFLNDRKISHVLSLInMPITVPSEVAV---NHKQIIIRDQPGEDllthLEDILAFMEDGLDpaKEGS
 |.|...|.||.| |              |.  |.| ...|.....|   .   |...     ..... . | .  |    |...|.|.|. |.  ..| 
ldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.eelywpellerlgiqylylpwpDhgvpd....ldelldfieevle..eggp

VLVHCAMGVSRSSSAVIAYIMYKEKCPLVTALKKVVDKHS--QTCPNTGFMEQLKLFEAMGCQCD
||||| .||.|. . |.||.|.| ...|  |.| |  . .   ..|| .|..||.|.| . .. .
vlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkkt
subfamily_Slingshot_pd Subfamily Slingshot 7-145 3.1e-23 76.0 In-house 21-156 (169) alignment 
Range on Protein: 7-145
Range on HMM: 21-156/169.0
EILPRLWLGDLQAAESERFLNDRKISHVLSLINmPITVPSEVAVNHKQIIIRDQPGEDLLTHLEDILAFMEDGLdpAKEGSVLVHCAMGVSRSSSAVIAY
.|   ..||    |     |........| . .  |    .  .....| . |.. .|||.. ..   |.|     .|. .||||| ||||||.|.||||
kifdhvylGsewnasnleelkengveyilnvtk.eidnffpekfeylnirvydeeetdllkywnetykfiekak..kkgskvlvhckmGvsrsastviay

IMYKEKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFEAM
 | . .. | .||. | .. | . ||.||..||. .| .
amkeyglsleealeyvkerrsvikPnkgflkqleeyeGi
0043147 (Phosphotyrosine protein) phosphatases II 5-145 1.7e-22 75.4 In-house 19-159 (172) alignment 
Range on Protein: 5-145
Range on HMM: 19-159/172.0
ADEILPRLWLGDLQAAESERFLNDRKISHVLSLINM--PITVPSEVAVNHKQIIIRDQPGEdLLTHLEDILAFMEDGLDPAKEGSVLVHCAMGVSRSSSA
 |.... .....   |.  |.| ...|.|...| .   . .  ..  . .  . . |..   || .|...| |... |   ..| ||||| .||.|.   
pdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtl

VIAYIMYkEKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFEAM
|.||.|. ....|  |.. | .| .. ..| ... .|. || .
vaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfekl
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 12-143 2.7e-22 72.8 In-house 10-149 (154) alignment 
Range on Protein: 12-143
Range on HMM: 10-149/154.0
LWLGDLQAAESERFLNDRKISHVLSL-INMPITVPSE-------VAVNHKQIIIRDQPGEDLLTHLEDILAFMEDGLDPAKEGSVLVHCAMGVSRSSSAV
|...  .||     |. ..| ..|   | ..   . |       . ... .. . |..  |.. .|.  . |..| .   ... ||||.  |||||.. .
lyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaall

IAYIMYKEKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFE
|.|.| | | .|  ||. . |   .  ||.||..||. ||
isylmdklkislslalellkdsryiikPnqGflkqleife
subfamily_STYXL1_pd Subfamily STYXL1 3-145 2.9e-22 72.6 In-house 9-152 (157) alignment 
Range on Protein: 3-145
Range on HMM: 9-152/157.0
GYADEILP-RLWLGDLQAAESERFLNDRKISHVLSLINM--PITVPSEVAVNHKQIIIRDQPGEDLLTHLEDILAFMEDGLDpaKEGSVLVHCAMGVSRS
 |  |.|| .|.||. . | ...  .| |.  .. . .   ..    . ...  .| . |..  |||..|...  |.|.     ..  |||    |.|||
tyPvevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkk..egevvlvfsnkGisrs

SSAVIAYIMYKEKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFEAM
 ...|||.||..|  | .|.|.. . ..  .|| .|.|||. .| .
aaviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekq
subfamily_MKPLT_pd Subfamily MKPLT 11-145 1.1e-21 71.0 In-house 28-159 (164) alignment 
Range on Protein: 11-145
Range on HMM: 28-159/164.0
RLWLGDLQAAESERFLNDRKISHVLSLINMPITVPSEvAVNHKQIIIRDQPGEDLLTHLEDILAFMEDGLDPakEGSVLVHCAMGVSRSSSAVIAYIMYK
.|.||. . |..|. |.| || |.. . .      .. .|.. |. . |.. | | ..|| .  |. | .|    | ||||| .|.|||||. .|...  
tlylGnakhatnekvlkdlkithivnvsqekkdafpk.sveYlqvkvedesdeqlssfleraakfladaids..GGrvlvhcvqGksrsssvtvafLiks

EKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFEAM
..  |  | . . .. | . || ||. ||  || .
kgwtlkeayeylkerrsivapnrGflkqlakfeel
subfamily_MKPLV_pd Subfamily MKPLV 11-145 1.1e-21 71.0 In-house 28-159 (164) alignment 
Range on Protein: 11-145
Range on HMM: 28-159/164.0
RLWLGDLQAAESERFLNDRKISHVLSLINMPITVPSEvAVNHKQIIIRDQPGEDLLTHLEDILAFMEDGLDPakEGSVLVHCAMGVSRSSSAVIAYIMYK
.|.||. . |..|. |.| || |.. . .      .. .|.. |. . |.. | | ..|| .  |. | .|    | ||||| .|.|||||. .|...  
tlylGnakhatnekvlkdlkithivnvsqekkdafpk.sveYlqvkvedesdeqlssfleraakfladaids..GGrvlvhcvqGksrsssvtvafLiks

EKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFEAM
..  |  | . . .. | . || ||. ||  || .
kgwtlkeayeylkerrsivapnrGflkqlakfeel
0046846 (Phosphotyrosine protein) phosphatases II 3-145 4.3e-20 67.6 In-house 10-171 (176) alignment 
Range on Protein: 3-145
Range on HMM: 10-171/176.0
GYADEILPRLWLGDLQ----------AAESERFLNDRKISHVLSLINM--------PITVPS--EVAVNHKQIIIRDQPGEDLlTHLEDILAFMEDGLDP
.. |.|...|.||..            |.  ..| . .|..|..| ..        |   |   .. . .... ..|    || ..|...|.|... |. 
ldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealke

AkeGSVLVHCAMGVSRSSSAVIAYIMYK-EKCPLVTALKKVVDKHS-QTCPNTGFMEQLKLFEAM
   | ||||| .|..|.   |.||....    ..  ||..| .... .  .. .....|. || .
g..gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefell
subfamily_DSP8_pd Subfamily DSP8 7-143 5.8e-20 65.4 In-house 17-151 (159) alignment 
Range on Protein: 7-143
Range on HMM: 17-151/159.0
EILPRLWLGDLQAAESERFLNDRKISHVLSLINMPITVPSEVAVNHKQIIIRDQPGEDLLTHLEDILAFMEDGLdpAKEGSVLVHCAMGVSRSSSAVIAY
.||. |.||  . . || .|..  ||.|| . |  ...     ..  .. ..|.  |.||  ..  . |..     ...|.||||.  | |||.. .|||
rilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkak..sengrvlvhvlaGisrsatvaiay

IMYKEKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFE
|| . .  |  | . | .|     ||  |..||  .|
imktlemsldeayrfvkekrptispnlnflgqLleye
0036282 (Phosphotyrosine protein) phosphatases II 7-143 2.2e-19 65.2 In-house 14-166 (174) alignment 
Range on Protein: 7-143
Range on HMM: 14-166/174.0
EILPRLWLGDLQAAeSERFLNDRKISHVLSLINMPI--------------TVPSEVAVNHKQIIIRDQPGEDLLThLEDILAFMEDGLDPAKEGSVLVHC
.|.|||..|.  .|   ..| . .|..|..|..                 . ...  ...... . |    || . |.... |.|. |   ..| |||||
yitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHC

AMGVSRSSSAVIAYIMYKEKC-PLVTALKKVVDKH---SQTCPNTGFMEQLKLFE
 .||.|.   |.||.|.. .. .|| ||. |  ..   .. ... .....|  ||
saGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfe
PTEN_1 3-145 3.8e-19 64.2 In-house 40-190 (196) alignment 
Range on Protein: 3-145
Range on HMM: 40-190/196.0
GYAdEILPRLWLGDLQAAES-ERFLNDRKISHVLSLINMPITvP---------SEVAVNHKQIIIRDQPGEDLLTHLEDILAFMEDGLDPAKEGSVLVHC
..  || ..|..| |  ...  . |  ..| .|..| . . . .          .  |..... |.| .  .|  ... .  |.|  |   ... |||||
llq.eideglyrgslkdvaadldnlkedgitlvvnlseeeel.sgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHC

AMGVSRSSSAVIAYIMYKEKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFEAM
. |..||   |.|| |||.|     ||. | .| .. .||....|.|. ..|.
kaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfae
0049260 (Phosphotyrosine protein) phosphatases II 7-143 4e-19 64.3 In-house 10-146 (152) alignment 
Range on Protein: 7-143
Range on HMM: 10-146/152.0
EILPRLWLGDLQAAESERFLNDRKISHVLSLINMPITV--PSEVAVNHKQIIIRDQPGEDLLTHLEDILAFMEDGlDPAKEGSVLVHCAMGVSRSSSAVI
|... ...|.  .|.  |.| . .|.....| .         |   ..... . | .  ||  .|...| |.|      |.| |||||  ||.|.   |.
efiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlva

AYIMYkEKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFE
||.|.  ...|  |.. |  | .. .|| |....|. ||
aylml.lgvsleeavalvrekRpgavpnpgqlrflyefe
0045098 (Phosphotyrosine protein) phosphatases II 3-147 1.9e-18 62.3 In-house 20-272 (278) alignment 
Range on Protein: 3-147
Range on HMM: 20-272/278.0
GYADEILPRLWLGDLQ-----------------------------------------AAESERFLNDRKISHVLSLINM---------------------
|. .||.| |.||.|                                          .|   |.| . .|.....| .                      
gipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltyg

-----------------------------PITVPSEVAVNHK-QIIIRDQPGEDLLTHLEDILAFMEDGLD------------PAKEGSVLVHCAMGVSR
                             .   . .| . |   .   . | ...|... ..| |... |.              ..| ||||| .||.|
dftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgR

SSSAVIAYIMYKE---KCPLVTALKKVVDKHSQ-TCPNTGFMEQLKLFEAMGC
.   |.||.|..    .. |  |.|..  .  .  ..| .....|  |...  
tGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 12-143 2.5e-18 60.0 In-house 15-144 (148) alignment 
Range on Protein: 12-143
Range on HMM: 15-144/148.0
LWLGDLQAAESERFLNDRKISHVLSLINMPITVPSEVAVNHKQIIIRDQPGEDLLTHLEDILAFMEDGLDpaKEGSVLVHCAMGVSRSSSAVIAYIMYKE
|.||. . | .   |..  .... .  .    .  . .... .. ..|.| ||| .  ||| ||..   |  . . ||||. |||||||  ......  .
LFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakd..eGrrvLvhlqmGvsrssalallwlidfk

KCPLVTALKKVVDKHSQTCPNTGFMEQLKLFE
.  |  ||  | .|     || ||..||  .|
rvslkealalvkskrryvdpnlgfLkqLaele
0051082 (Phosphotyrosine protein) phosphatases II 6-140 4.1e-18 60.9 In-house 9-147 (151) alignment 
Range on Protein: 6-140
Range on HMM: 9-147/151.0
DEILPRLWLGDLQAAESERFLNDRKISHVLSLINMP-----ITVPSEVAVNHKQIIIRDQPGEDLLTHLEDILAFMEDGLDpAKEGSVLVHCAMGVSRSS
  . ..|....   |.  ..| . .|.....| . .          |  .....| | | |  .| .... .|.|.|  ||  |.| ||||| .|..|. 
syvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellld.kkngpvlvHCsaGkgRTG

SAVIAYIMYkEKCPLVTALKKVVDKHS-QTCPNTGFMEQLK
  |..|.|. ....| .||. .  |.   ..||..|. ||.
tlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlf
0037934 (Phosphotyrosine protein) phosphatases II 7-144 1.5e-17 59.4 In-house 41-239 (243) alignment 
Range on Protein: 7-144
Range on HMM: 41-239/243.0
EILPRLWLGDL--------QAAESERFLNDRKISHVLSLINMP--------------------------------------------ITVPSEVAVNHKQ
...|||.....         .|.  |.| . .|.....| .                                              .. ..   ... .
yvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhy

IIIRD----QPGEDLLTHLEDILAFMED---GLDPAKEGSVLVHCAMGVSRSSSAVIAYIMYKE-KCPLVTALKKVVDKHSQ-TCPNTGFMEQLKLFEA
. . |    .  |||| .|... .|.|.    |   ..| ||||| .||.|.   ..||.|..  ...|  |.|.. .. ..  ... .....|  ...
lpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeall
0040439 (Phosphotyrosine protein) phosphatases II 24-145 1.3e-16 56.4 In-house 72-244 (249) alignment 
Range on Protein: 24-145
Range on HMM: 72-244/249.0
RFLNDRKISHVLSLINMPIT-----------------------------------------V-PSEVAVNHKQIIIRDQPGEDLLTHLEDILAFMEDGLD
|.| . .|.....| .                                                    .  ..| . | |  ..  ..||.|.|.|  ..
rmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrk

PA----KEGSVLVHCAMGVSRSSSAVIAYIM-----YKEKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFEAM
      |.| ||||| .||.|.   ..||.|     .. . .|  |.|.. .. .. ..| .....|  ....
aleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle
0042113 (Phosphotyrosine protein) phosphatases II 7-144 2.5e-16 55.3 In-house 49-240 (245) alignment 
Range on Protein: 7-144
Range on HMM: 49-240/245.0
EILPRLWLGDLQAAESER----FLNDRKISHVLSLINMP---------------------------------------------ITVPSEVAVNHKQIII
.| |......  ..|.      .| . .|.....| .                                                . .|   ... .. .
ritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpw

RDQPGEDLLTHLEDILAFMEDGLDPAKEGSVLVHCAMGVSRSSSAVIAYIM-----YKEKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFEA
 |..  ||| .|.|.| |... |   ..| ||||| .||.|.   ..||.|     .  . .|  |.|.. .. .. ... .....|  ...
pdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall
0045450 (Phosphotyrosine protein) phosphatases II 25-145 2.8e-16 55.6 In-house 126-302 (307) alignment 
Range on Protein: 25-145
Range on HMM: 126-302/307.0
FLNDRKISHVLSLINM------------------------------------------PITV--PSEVAVNHKQIIIRDQPGEDLLTHLEDILAFMEDGL
.| . .......| .                                           ..|   ...    .....  . |. .. ...|..|.|.|  .
mlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevr

D----PAKEGSVLVHCAMGVSRSSSAVIAYIMYKEK--------CPLVTALKKVVDKHSQTCPNTGFMEQLKLFEAM
.      |.| ||||| .||.|. . ..||.|..          ..|  |.|.. .. .. ..| .....|  ....
kaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
subfamily_STYX_pd Subfamily STYX 6-145 7.1e-16 51.7 In-house 13-156 (166) alignment 
Range on Protein: 6-145
Range on HMM: 13-156/166.0
DEILPRLWLGDLQAAESER--FLNDRKISHVLSLINMP---ITVPSeVAVNH--KQIIIRDQPGEDLLTHLEDILAFMEDGLDpaKEGSVLVHCAMGVSR
.|||| |.||   ||   .   |... |.|.. . . .   .  |     .     . . |.. |... .|  . .|..| |.  | | ||||   |.||
qeilpglflgpysaamksklevlkkhgithivcirqnieanlikpn.fpdrfrylvldvadntveniirylptvkefiddslq..kggkvlvhgnagisr

SSSAVIAYIMYKEKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFEAM
|.. ||||||        .| . | ..     || ||..||| .||.
saalviayimetyglkyreafayvqerrfcinpnegfvsqlkeyeai
0040438 (Phosphotyrosine protein) phosphatases II 24-153 1.9e-14 49.1 In-house 104-282 (317) alignment 
Range on Protein: 24-153
Range on HMM: 104-282/317.0
RFLNDRKISHVLSLINMP--------------------------ITVPSEVAVNHKQIIIRDQ----------------PGEDLLTHLEDILAFMEDGLD
|.. . .......| .                            . .  .  ... .. . |                 |  ..  .....|.|.|   .
rmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavre

P--AKEGSVLVHCAMGVSRSSSAVIAYIM-----YKEKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFEAMGCQCDTTN
    ..| ||||| .||.|. . ..||.|     ..... .  |.|..  . .. ... .....|  .... ...  | 
aledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltl
0036941 (Phosphotyrosine protein) phosphatases II 28-152 2.4e-14 48.8 In-house 100-282 (297) alignment 
Range on Protein: 28-152
Range on HMM: 100-282/297.0
DRKISHVLSLINMP-------------------------ITV---------------------PSEVAVNHKQIIIRDQPGEDLLTHLEDILAFMEDGLD
. .......| .                           .|.                      ..     ... . . |  .. .. ...|.|.|  ..
eqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrk

--PA--KEGSVLVHCAMGVSRSSSAVIAYIM--------YKEKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFEAMGCQCDTT
  ..  ..| ||||| .||.|| . ..|..|        . ...... |.||. ..  . ... .....|  .... ... .|
vlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt
0051429 (Phosphotyrosine protein) phosphatases II 8-144 5.4e-13 44.7 In-house 19-222 (272) alignment 
Range on Protein: 8-144
Range on HMM: 19-222/272.0
ILPR-LWLGDLQ---AAESERFLNDRKISHVLSLINMP-------ITVPseVAVNHKQIIIRDQPGEDLLTHL---------------------------
..|. |....      |.. ..| . .|.....| .           ..    ... .. | |   .. | .                            
vkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdryw..pgirylhlpilddsaptilygalrvtllseellldyilrellltlllsa

---------------------EDILAFMEDGLDpakEGSVLVHCAMGVSRSSSAVIAYIMYkEKCP--------------LVTALKKVVDKHSQTCPNTG
                     | .|...|  ||   .| |||||. |..|.  .| ..... .  .              |  |.... ..  .  .. .
gearevmhlhytdwpdhgvpqeallellellld...ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqtee

FMEQLKLFEA
....|  ...
qylflyeall
0039614 (Phosphotyrosine protein) phosphatases II 28-147 1.4e-12 43.2 In-house 123-289 (297) alignment 
Range on Protein: 28-147
Range on HMM: 123-289/297.0
DRKISHVLSLINMP-------ITVPSEVAvNHKQIII-----------------------------------RDQPGEDLLTHLEDILAFMEDGLDPA-K
. .......| .            |.|.  ..... .                                    |    ..|..| ..| .... |  . |
eqgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpk

EGSVLVHCAMGVSRSSSAVIAYIM-----YKEKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFEAMGC
.| ||||| .||.|. . ..||.|     .. .  .  |.|..  . .. ... .....|  .... .
ggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
0038934 (Phosphotyrosine protein) phosphatases II 50-143 1.7e-12 42.9 In-house 80-173 (194) alignment 
Range on Protein: 50-143
Range on HMM: 80-173/194.0
VNHKQIIIRDQPGEDLLTHLEDILAFMEDGLDPAKEGSVLVHCAMGVSRSSSAVIAYIMYKEKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFE
. . .... |.     |  | ..| .... |.  ..| |.||| .|..|.   |.||..|. ....  |.. . .|     || ...|.|  . 
ieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkry
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 55-139 7.3e-12 38.6 In-house 52-134 (145) alignment 
Range on Protein: 55-139
Range on HMM: 52-134/145.0
IIIRDQPGEDLLTHLEDILAFMEDGLDpaKEGSVLVHCAMGVSRSSSAVIAYIMYKEKCPLVTALKKVVDKHSQTCPNTGFMEQL
|   |    ||  |....  |.. | .  .   |.|||  ||||| .  .|..|   .  |  | ..|  .  ...||  |. .|
itaedlesydlsqhfdevtdfidkgke..egagvfvhcmagvsrsvtvsvaflmkycnmtlseaarqvrsnrllaypnvtflknl
subfamily_MSG5_pd Subfamily MSG5 84-145 4.3e-10 33.0 In-house 98-159 (165) alignment 
Range on Protein: 84-145
Range on HMM: 98-159/165.0
KEGSVLVHCAMGVSRSSSAVIAYIMYKEKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFEAM
|.  .||||  |.|||.| ..||||   .  |  | .|.  .  .  |. |.. ||  .|..
krkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmeweva
0043336 (Phosphotyrosine protein) phosphatases II 26-144 4.9e-10 34.8 In-house 108-274 (278) alignment 
Range on Protein: 26-144
Range on HMM: 108-274/278.0
LNDRKISHVLSLINMP----------------------------------------ITV-PSEVAVNHKQIIIRDQPGEDLLTHLEDILAFMEDGLDP--
. . .......| .                                          .|   .     . ..   . |  .. ..|...| |... ..   
vwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale

AKEGSVLVHCAMGVSRSSSAVIAYIM-----YKEKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFEA
 ..| |||||  ||.|.   ...|..     .  . .|  |.|..  .  . ...  ....|  ...
dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall
subfamily_PTPMT1_pd Subfamily PTPMT1 49-144 6.9e-10 33.6 In-house 73-166 (171) alignment 
Range on Protein: 49-144
Range on HMM: 73-166/171.0
AVNHKQIIIRDQPGEDLLTHLEDILAFMEDGLDpaKEGSVLVHCAMGVSRSSSAVIAYIMYKEKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFEA
 |.. |. . |  ..  | .||. . |.|.  .  |  .| |||  | .||.. |..|.|.|||. . .||| . .| ...  ..  ...|. .| 
gveqlqlatvDfteapdleklekgvefiekvas..kgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyee
0051299 (Phosphotyrosine protein) phosphatases II 32-125 9.6e-09 30.6 In-house 164-264 (288) alignment 
Range on Protein: 32-125
Range on HMM: 164-264/288.0
SHVLSLINMPITVPSEVAVNHKQIIIRDQPGEDLLTHLEDILAFMEDGLDP--AKEGSVLVHCAMGVSRSSSAVIAYIM-----YKEKCPLVTALKKVVD
 ..| . |. .. ...   . ...   . |  .  ...|..|.|...  .   ...| |.|||  ||.|.   ......     ..... .  |.|..  
vrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlre

K
.
q
0047943 (Phosphotyrosine protein) phosphatases II 54-139 2.1e-08 29.4 In-house 170-264 (273) alignment 
Range on Protein: 54-139
Range on HMM: 170-264/273.0
QIIIRDQPGEDLLTHLEDILAFMEDGLD---PA-KEGSVLVHCAMGVSRSSSAVIAYIM-----YKEKCPLVTALKKVVDKHSQTCPNTGFMEQL
..   . |  .  ..||..| |.|.  .    . ..| |.|||  ||.|. . ......     .. .  .  |.|.. ..     ..  ....|
hfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl
0046845 (Phosphotyrosine protein) phosphatases II 46-125 4.5e-08 28.3 In-house 161-252 (284) alignment 
Range on Protein: 46-125
Range on HMM: 161-252/284.0
SEVAVNHKQIIIRDQPGEDLLTHLEDILAFMEDGLDP----AKEGSVLVHCAMGVSRSSSAVIAYIMYKE--------KCPLVTALKKVVDK
..  . .... . . |  .  ...||.|.|...  .      ..| ..|||  ||.|.   ........         ....  |.|.. ..
tgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreq
0050432 (Phosphotyrosine protein) phosphatases II 53-122 6.7e-08 27.7 In-house 200-274 (308) alignment 
Range on Protein: 53-122
Range on HMM: 200-274/308.0
KQIIIRDQPGEDLLTHLEDILAFMEDGLDPAKEGSVLVHCAMGVSRSSSAVIAYIM-----YKEKCPLVTALKKV
...   . |  .  ...|..|.|.|   .  ..| ..|||  ||.|.   ......     .. .. .  |.||.
thfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkkl
subfamily_PTPDC1_pd Subfamily PTPDC1 83-143 5.9e-06 20.8 In-house 112-172 (182) alignment 
Range on Protein: 83-143
Range on HMM: 112-172/182.0
AKEGSVLVHCAMGVSRSSSAVIAYIMYKEKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFE
 .|| | |||  |  |    . .|..|...     |.|.| .| ...    . .| .| |.
lqegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelvkefa
PTPc_DSPc_SM00012 63-111 6.6e-06 21.6 In-house 20-65 (105) alignment 
Range on Protein: 63-111
Range on HMM: 20-65/105.0
EDLLTHLEDILAFMEDGLDpakEGSVLVHCAMGVSRSSSAVIAYIMYKE
...|..|...  ....  .   ...|.|||  ||.|.   | ..|... 
dsilellravkknknkses...skpvvVhCsaGvgRtgtfvaldillqq
subfamily_DSP23_pd Subfamily DSP23 21-121 7.8e-06 20.6 In-house 22-120 (148) alignment 
Range on Protein: 21-121
Range on HMM: 22-120/148.0
ESERFLNDRKISHVLSLIN-MPITVPSEVAVNHKQIIIRDQPGeDLLTHLEDILAFMEDGldPAKEGSVLVHCAMGVSRSSSAVIAYIMYKEKCPLVTAL
.  |.| |  . ...|| .  .  | .  ..  ... | |      |  .....  .|.    .|. .| |||..|  |. . .  |.. ..|     |.
dqyrylldlgvrylvslteegrphveatpnltlvrlriddyhp.paleqvvefvrvveea..eekneavsvhcllgrgrtgtmlacylvkerklaaaeai

KK
 .
ae