Gene DSP15 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP15
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP013_AA protein Get Run
SpurP013_AA_2-146 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP15_pd Subfamily DSP15 4-154 2.1e-76 249.2 In-house 1-151 (151) alignment 
Range on Protein: 4-154
Range on HMM: 1-151/151.0
GMSEVLKGVFVGNFRDSKDETQLGNNNITHILSIHDNAKPIRPDKEYLCFSADDAPGQNLIQFFSESNNFIHKCRLEGGNVLIHCLAGVSRSVTLTVAYM
|.|.||.|...|||||||||..|...|||||||.|||||....|.||.|..|.|.|...| .||.||..|||||||...|||.||||||||||||.|||.
giskvlpglylgnfrdskdeelLkeknithilsvhdnakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYl

MTVTDYKWEDCLRAVKTCRTVAHPNFGFQRQLQEYEYSKLAEYKEDIRLKF
||||...|.|.|...|..|.||.|||||.|||.|||..||.||..... .|
mtvtelnwrdalevikaaRsvanPnfGfkrqlkeyektklkeyrkqlkeef
PTPc_motif_SM00404 5-139 7.5e-37 121.3 In-house 2-138 (140) alignment 
Range on Protein: 5-139
Range on HMM: 2-138/140.0
MSEVLKGVFVGNFRDSKDETQLGNNNITHILSIHDNAKP--IRPDKEYLCFSADDAPGQNLIQFFSESNNFIHKCRLEGGNVLIHCLAGVSRSVTLTVAY
.|..|.....|. ...... .| ...|||.... .. .     .....|.   ||   ..| ..... ..||.... .||.||.|| ||||||.||..||
psrilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaY

MMTVTDYKWEDCLRAVKTCRTVAHPNFGFQRQLQEYE
.|.   .........||  |    ||..| |||.|||
lmryrqlslaeayefvkerRpiispnlnfvrqLieye
subfamily_DSP19_pd Subfamily DSP19 6-142 6.4e-36 118.0 In-house 13-150 (152) alignment 
Range on Protein: 6-142
Range on HMM: 13-150/152.0
SEVLKGVFVGNFRDSKDETQLGNNNITHILSIHDNAKPI-RPDKEYLCFSADDAPGQNLIQFFSESNNFIHKCRLEGGNVLIHCLAGVSRSVTLTVAYMM
.|| . ...|     .|...| ...|||||..  . . .   | .||. .  | | ..|.....|. .||.. | . | ||.|| ||||||... .||.|
geveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylm

TVTDYKWEDCLRAVKTCRTVAHPNFGFQRQLQEYEYSK
. .. . |..|. |.. |  ..|| ||..||.||| ..
kkeelsleealelvrearpcikPneGFikqLkeyeael
0044763 (Phosphotyrosine protein) phosphatases II 3-141 7.6e-35 115.5 In-house 21-169 (178) alignment 
Range on Protein: 3-141
Range on HMM: 21-169/178.0
NGMSEVLKGVFVGNFRDSKDETQLGNNNITHILSIHDNAKPIRP----------DKEYLCFSADDAPGQNLIQFFSESNNFIHKCR-LEGGNVLIHCLAG
...||.| |...|.. ...|  .| ...||||... ..  . ..          . .||..  .| . ..|...| |  .||....  .||.||.|| ||
inaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaG

VSRSVTLTVAYMMTVTDYKWEDCLRAVKTCRTvAHPNFGFQRQLQEYEYS
|.|| || .||.| . .. .|.... |. .|  . ||.|..|||.|.|  
vgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelr
subfamily_DSP12_pd Subfamily DSP12 5-144 4e-34 112.3 In-house 2-145 (155) alignment 
Range on Protein: 5-144
Range on HMM: 2-145/155.0
MSEVLKGVFVGNFRDSKDETQLGNNNITHILSIHDNAK---PIRPDKE-YLCFSADDAPGQNLIQFFSESNNFIHKCRLEGGNVLIHCLAGVSRSVTLTV
.|..|.|...|. .. ..|..| . .|||.||.  ..     ... |  ..   ..| | ....... | ..||.... |.|.||.|| ||||||||. .
vsrilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtivi

AYMMTVTDYKWEDCLRAVKTCRTVAHPNFGFQRQLQEYEYSKLA
||.|  .. . |. |..||. .  ..|| ||..||. .| ..  
AYlmkkeklslekAlklvkekkpeiepNegFleQLklfekmgck
0048076 (Phosphotyrosine protein) phosphatases II 4-140 1.6e-32 107.6 In-house 3-140 (145) alignment 
Range on Protein: 4-140
Range on HMM: 3-140/145.0
GMSEVLKGVFVGNFRDSKDETQLGNNNITHILSI-HDNAKPIRPDKEYLCFSADDAPGQNLIQFFSESNNFIHKCRLEGGNVLIHCLAGVSRSVTLTVAY
..||.| |...|.. . .|  .| ...||..|.. ..   . | . .||... .| . ..|.... |  .||.... |||.||.|| |||.|. || .||
wpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaay

MMTVTDYKWEDCLRAVKTCRTVAHPNFGFQRQLQEYEY
.|   .. .|..|. |...|  | ||.|..|.|.|.|.
lmlllgvsleealelvrsqrpgavpnpgqlrflyefel
DSPc Dual specificity phosphatase, catalytic domain 12-139 1.6e-32 107.1 Pfam-A 1-131 (133) alignment 
Range on Protein: 12-139
Range on HMM: 1-131/133.0
VFVGNFRDSKdETQLGNNNITHILSIHDNAKP----IRPDKEYLCFSADDAPGQNLIQFFSESNNFIHKCRLEGGNVLIHCLAGVSRSVTLTVAYMMTVT
...|.  ... ...| ...||..... .. .       ...|||.   .|   ... ....|. .||.|.. .|..||.|| ||.||| ||..||.|.  
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

DYKWEDCLRAVKTCRTVAHPNFGFQRQLQEYE
 .. ......||  |    ||.||.||| |||
nlslneAyefvkerrskispnagflrqLleye
DSPc Dual specificity phosphatase, catalytic domain 12-139 1.6e-32 107.1 In-house 1-131 (133) alignment 
Range on Protein: 12-139
Range on HMM: 1-131/133.0
VFVGNFRDSKdETQLGNNNITHILSIHDNAKP----IRPDKEYLCFSADDAPGQNLIQFFSESNNFIHKCRLEGGNVLIHCLAGVSRSVTLTVAYMMTVT
...|.  ... ...| ...||..... .. .       ...|||.   .|   ... ....|. .||.|.. .|..||.|| ||.||| ||..||.|.  
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

DYKWEDCLRAVKTCRTVAHPNFGFQRQLQEYE
 .. ......||  |    ||.||.||| |||
nlslneAyefvkerrskispnagflrqLleye
0048179 (Phosphotyrosine protein) phosphatases II 3-139 2.4e-32 107.0 In-house 2-141 (144) alignment 
Range on Protein: 3-139
Range on HMM: 2-141/144.0
NGMSEVLKGVFVGNFRDSKDETQLGNNNITHILSIH---DNAKPIRPDKEYLCFSADDAPGQNLIQFFSESNNFIHKCRLEGGNVLIHCLAGVSRSVTLT
. .||.| |...|.. ...|  .| ...||.....    ... ..|.  .||... .| .  .|.... |  .||.... |||.||.|| |||.|. || 
snpseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlv

VAYMMTVTDYKWEDCLRAVKTCRTVAHPNFGFQRQLQEYE
.||.| . .. .|..|. |...|  |.||.|. |.|.|||
aaylmkklglsleealalvrsrrpgavpnpgqlrfLleye
subfamily_LRR-DSP_pd Subfamily LRR-DSP 6-140 7.3e-32 104.5 In-house 121-256 (263) alignment 
Range on Protein: 6-140
Range on HMM: 121-256/263.0
SEVLKGVFVGNFRDSKDETQLGNNNITHILSIHDNAKPIRPDK-EYLCF-SADDAPGQNLIQFFSESNNFIHKCRLEGGnVLIHCLAGVSRSVTLTVAYM
.|.....|.|    ..... | ....||||    . .|. |.   ||    ..|..  .. |.| | | ||.. | .|| ||.|| |||||| ||...|.
deiidklflGgldsannksilkdlgvthillavadfePlfPklfkylsiddiedvdeadisqhfeetnafieeGrkkGG.vlvhcraGvsrsstlvisyl

MTVTDYKWEDCLRAVKTCRTVAHPNFGFQRQLQEYEY
|     |... |  |.  |.  .|| ||. ||. || 
mkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyek
subfamily_DSP10_pd Subfamily DSP10 4-140 8.4e-32 104.2 In-house 13-151 (159) alignment 
Range on Protein: 4-140
Range on HMM: 13-151/159.0
GMSEVLKGVFVGNFRDSKDETQLGNNNITHILSIHDNAkPIRPDK---EYLCFSADDAPGQNLIQFFSESNNFIHKCRLEGGNVLIHCLAGVSRSVTLTV
 .|.||  .|.|. .|..|.. | . |||..| .  .  |   ..   .|    . |.  ||| | | |. .||.. | .| .||.|| ||.|||.|...
pasqvlpfLflGsekdaadldaldrlnitavlnvttsv.PnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvvi

AYMMTVTDYKWEDCLRAVKTCRTVAHPNFGFQRQLQEYEY
||.|. .. . .|  . ||..|..  ||..|  || |.| 
aYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefek
subfamily_DSP1_pd Subfamily DSP1 8-145 4.5e-31 102.1 In-house 21-159 (163) alignment 
Range on Protein: 8-145
Range on HMM: 21-159/163.0
VLKGVFVGNFRDSKDETQLGNNNITHILSIHDNAKPIRPD-KEYLCFSADDAPGQNLIQFFSESNNFIHKCRLEGGNVLIHCLAGVSRSVTLTVAYMMTV
.|  ...|   .. .  .| ...||.|| .  . . . .|  || .   .| | ... . |.|  .||.... ..| ||||| ||.||| || .||.|. 
ildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlclaylmkt

TDYKWEDCLRAVKTCRTVAHPNFGFQRQLQEYEYSKLAE
. .. |.    ||  |.. .||.||..|| .|| . |.|
krvsleeafdfvkqrRsiisPnagFvlqLlnyekkllle
subfamily_DSP14_pd Subfamily DSP14 4-141 7.8e-31 101.1 In-house 6-143 (157) alignment 
Range on Protein: 4-141
Range on HMM: 6-143/157.0
GMSEVLKGVFVGnFRDSKDETQLGNNNITHILSIH-DNAKPIRPDKEYLCFSADDAPGQNLIQFFSESNNFIHKCRLEGGNVLIHCLAGVSRSVTLTVAY
..|.. .  |..  . ......| ...||.|. .  .  ..  .| |..   ..|.| ..| ..| |  . |.. . .||..|.|| |||||| .|..||
alsqitpsLfls.gvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclay

MMTVTDYKWEDCLRAVKTCRTVAHPNFGFQRQLQEYEYS
.|       ..  ..||..| . .|| || .||..||  
lmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkk
subfamily_DSP6_pd Subfamily DSP6 7-140 8.3e-31 100.6 In-house 16-152 (158) alignment 
Range on Protein: 7-140
Range on HMM: 16-152/158.0
EVLKGVFVGNFRDSKDETQLGNNNITHILSIHDNAKPIRP---DKEYLCFSADDAPGQNLIQFFSESNNFIHKCRLEGGNVLIHCLAGVSRSVTLTVAYM
|.|. ...|. .|...   | . .| ..| .  |   .     . .||  ...|   ||| .|| |. .|| . | .  .||.|||||.|||||.|.||.
eilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtlayl

MTVTDYKWEDCLRAVKTCRTVAHPNFGFQRQLQEYEY
|  . .  .|    ||. ..   ||| |  || ..| 
mkklalslndaydlvkkrksnisPnfnfmgqlldfer
0043147 (Phosphotyrosine protein) phosphatases II 7-142 1.3e-30 101.8 In-house 21-160 (172) alignment 
Range on Protein: 7-142
Range on HMM: 21-160/172.0
EVLKGVFVGNFRDSKDETQLGNNNITHILSIHD----NAKPIRPDKEYLCFSADDAPGQnLIQFFSESNNFIHK--CRLEGGNVLIHCLAGVSRSVTLTV
... . ..... ....  .| ...||||... .      .  | . .||... .| . . |.... |  .||..  .. .|| ||.|| |||.|..|| .
rfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlva

AYMMTvTDYKWEDCLRAVKTCRTVAHPNFGFQRQLQEYEYSK
||.|   ....|.... |...|  | .|....|.|...|   
aylml.lglsleeavalvrekRpgavqnpsqyrflyyfekll
0049772 (Phosphotyrosine protein) phosphatases II 16-176 1.2e-29 99.4 In-house 156-308 (314) alignment 
Range on Protein: 16-176
Range on HMM: 156-308/314.0
NFRDSKDETQLGnnnithilSIHD-NAKPIRPDKEYLCFSADDaPGQNLIQFFSESNNFIHKCrLEGGNVLIHCLAGVSRSVT-LTVAYMMTVTDYKWED
|. . .|  .|         .... . .. |.  .||..  .| ....|...| |  .||...  .||.||.|| ||..|. | ...||.|   .. .|.
neptaadlellk........eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvslee

CLRAVKTCRTvAHPNFGFQRQLQEYEYSKLA-EYKEDIRLKFPEYSPEEDIKKMQALLEKYHQE
.|. |. .|. ..||.|| .||..||.   | ... .  .||.|| .|.  ...| | .....|
aledvrlkRp.inpnpgfieqleqyefilealleylkflkkfyeyleenlldglqllisellke
0041856 (Phosphotyrosine protein) phosphatases II 4-144 1.7e-29 98.1 In-house 18-174 (182) alignment 
Range on Protein: 4-144
Range on HMM: 18-174/182.0
GMSEVLKGVFVGNFRD--------------SKDETQLGNNNITHILSIHdnA------KPIRPDKEYLCFSADDAPGQNliqfFSESNNFIHKCRLEGGN
...... ....|....               .. ..| ...||.|...          .  |   .||... .| .  .    ..| ..||.... |||.
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..eelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeggp

VLIHCLAGVSRSVTLTVAYMMTVTDYKWEDCLRAVKTCRT--VAHPNFGFQRQLQEYEYSKLA
||.|| |||.|. || .||.| . .. .|.... |. .|   | .||..| .||...|. .| 
vlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllk
PTEN_1 5-145 2.6e-28 94.2 In-house 41-194 (196) alignment 
Range on Protein: 5-145
Range on HMM: 41-194/196.0
MSEVLKGVFVGNFRDS-KDETQLGNNNITHILSIHDNAKP----------IRPDKEYLCFSADDAPGQNLIQFFSESNNFIHKCRL--EGGNVLIHCLAG
..|. .|...|. .|  .|  .|. ..||....  .  .           .. . ||| |. .| . ..| ..| . ..||. ...  .|..||.|| ||
lqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaG

VSRSVTLTVAYMMTVTDYKWEDCLRAVKTCRTVAHPNFGFQRQLQEYEYSKLAE
..||.|.  ||.|    .  .. |. |. .|....|| ..|..|.||... |||
lgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaellae
subfamily_DSP8_pd Subfamily DSP8 4-140 2.5e-27 89.4 In-house 14-152 (159) alignment 
Range on Protein: 4-140
Range on HMM: 14-152/159.0
GMSEVLKGVFVGNFRDSKDETQLGNNNITHILSIH--DNAKPIRPDKEYLCFSADDAPGQNLIQFFSESNNFIHKCRLEGGNVLIHCLAGVSRSVTLTVA
|. ..|| ...|  .|. .|. | ...|...| .   . ..   .....|     |    .|...| .| .|| |.. | |.||.|.||| ||| |. .|
gptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaia

YMMTVTDYKWEDCLRAVKTCRTVAHPNFGFQRQLQEYEY
|.|   . . ... | ||  |..  ||. |. || ||| 
yimktlemsldeayrfvkekrptispnlnflgqLleyek
subfamily_DSP3_pd Subfamily DSP3 5-140 4e-27 88.9 In-house 11-155 (162) alignment 
Range on Protein: 5-140
Range on HMM: 11-155/162.0
MSEVLKGVFVGNFRDSKDETQLGNNNITHILSIHDN-AKPI-------R-PDKEYLCFSADDAPGQNLIQFFSESNNFIHKCRL-EGGNVLIHCLAGVSR
. || ....||.   .||...| .  |||.|   .   . .       .  . .|| . .||.|  .| ..|... .||..    . | ||.|| .||||
vdevypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsR

SVTLTVAYMMTVTDYKWEDCLRAVKTCRTVaHPNFGFQRQLQEYEY
| || .||.| . . .  . .|.|.. |..  || || .||.|.. 
satlvlayLmirrkmtlveairtvrkkRei.lPneGFlkqLaelde
0049260 (Phosphotyrosine protein) phosphatases II 9-139 2.3e-26 87.7 In-house 12-146 (152) alignment 
Range on Protein: 9-139
Range on HMM: 12-146/152.0
LKGVFVGNFRDSKDETQLGNNNITHILSIHDNAKP----IRPDKEYLCFSADDAPGQNLIQFFSESNNFIHK-CRLEGGNVLIHCLAGVSRSVTLTVAYM
. . ..|.   ...  .| ...||.|... .             .||..  .| . ..|.|.. . . ||.| .. .||.||.|| |||.|. || .||.
iatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaayl

MTvTDYKWEDCLRAVKTCRTVAHPNFGFQRQLQEYE
|   ....|.... |...| .| ||.|. |.|.|.|
ml.lgvsleeavalvrekRpgavpnpgqlrflyefe
subfamily_STYX_pd Subfamily STYX 4-147 4.5e-26 84.9 In-house 11-162 (166) alignment 
Range on Protein: 4-147
Range on HMM: 11-162/166.0
GMSEVLKGVFVGNFRDSKD--ETQLGNNNITHILSIHDNA--KPIRPD----KEYLCFSADDAPGQNLIQFFSESNNFIHKCRLEGGNVLIHCLAGVSRS
 | |.| |.|.| .  ..     .| .. ||||. | .|   . |.|.      || .   |.. .|.|... .  .|| ..  .||.||.|  ||.|||
emqeilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrs

VTLTVAYMMTVTDYKWEDCLRAVKTCRTVAHPNFGFQRQLQEYEYSKLAEYK
 .| .||.|     |. .. . |.  |    || || .||.|||   ||...
aalviayimetyglkyreafayvqerrfcinpnegfvsqlkeyeaiylaklt
0037934 (Phosphotyrosine protein) phosphatases II 5-140 2.1e-25 85.2 In-house 39-239 (243) alignment 
Range on Protein: 5-140
Range on HMM: 39-239/243.0
MSEVLKGVFVGNF--------RDSKDETQLGNNNITHILSIHD----------------------------------------------NAKPIRPDKEY
...|.........        .. ..   | ...||.|... .                                                .. | .  |
liyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihy

LCFSADD----APGQNLIQFFSESNNFIHK-----CRLEGGNVLIHCLAGVSRSVTLTVAYMMTVT-DYKWEDCLRAVKTCRTV-AHPNFGFQRQLQEYE
....  |       ..|..|..| ..||..     .. .|| ||.|| |||.|. || .||.|    .. .|.... ....|   | ..... |.|.|..
hylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeal

Y
.
l
subfamily_MKPLT_pd Subfamily MKPLT 10-140 3.4e-25 82.5 In-house 27-158 (164) alignment 
Range on Protein: 10-140
Range on HMM: 27-158/164.0
KGVFVGNFRDSKDETQLGNNNITHILSIHDNAKPIRPD-KEYLCFSADDAPGQNLIQFFSESNNFIHKCRLEGGNVLIHCLAGVSRSVTLTVAYMMTVTD
. .. ||  ....|. | . .||||. .  . |   |   |||  . .| . ..|..|.   ..|. .    || ||.||  |.||| . |||....   
dtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskg

YKWEDCLRAVKTCRTVAHPNFGFQRQLQEYEY
.  ..    .|  |... || || .|| ..| 
wtlkeayeylkerrsivapnrGflkqlakfee
subfamily_MKPLV_pd Subfamily MKPLV 10-140 3.4e-25 82.5 In-house 27-158 (164) alignment 
Range on Protein: 10-140
Range on HMM: 27-158/164.0
KGVFVGNFRDSKDETQLGNNNITHILSIHDNAKPIRPD-KEYLCFSADDAPGQNLIQFFSESNNFIHKCRLEGGNVLIHCLAGVSRSVTLTVAYMMTVTD
. .. ||  ....|. | . .||||. .  . |   |   |||  . .| . ..|..|.   ..|. .    || ||.||  |.||| . |||....   
dtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskg

YKWEDCLRAVKTCRTVAHPNFGFQRQLQEYEY
.  ..    .|  |... || || .|| ..| 
wtlkeayeylkerrsivapnrGflkqlakfee
0046846 (Phosphotyrosine protein) phosphatases II 3-140 9.4e-25 82.8 In-house 10-170 (176) alignment 
Range on Protein: 3-140
Range on HMM: 10-170/176.0
NGMSEVLKGVFVGNFR----------DSKDETQLGNNNITHILSIHDN------------AKPIRPDKEYLCFSADDAPGQNLiQFFSESNNFIHKCRLE
....... ....|..             ..  .| ...||..... .                 ... .||..  .|    .| . . |  .||.... |
ldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealke

GGNVLIHCLAGVSRSVTLTVAYMMTV-TDYKWEDCLRAVKTCRT-VAHPNFGFQRQLQEYEY
||.||.|| ||..|. || .||..    ....|..|. |. .|   | ..... |.|.|.|.
ggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefel
subfamily_Slingshot_pd Subfamily Slingshot 6-140 1.4e-24 80.4 In-house 20-155 (169) alignment 
Range on Protein: 6-140
Range on HMM: 20-155/169.0
SEVLKGVFVGNFRDSKDETQLGNNNITHILSIHDNAKPIRPDK-EYLCFSADDAPGQNLIQFFSESNNFIHKCRLEGGNVLIHCLAGVSRSVTLTVAYMM
|.. . |..|   .. .  .| .|....|| .  . .   |.| |||  .  | . ..|.... |. .||.|.. .| .||.||  ||||| .  .|| |
skifdhvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviayam

TVTDYKWEDCLRAVKTCRTVAHPNFGFQRQLQEYEY
   ... |..|. ||  |.|..|| || .||.||| 
keyglsleealeyvkerrsvikPnkgflkqleeyeG
0045098 (Phosphotyrosine protein) phosphatases II 5-143 1.5e-24 82.3 In-house 22-272 (278) alignment 
Range on Protein: 5-143
Range on HMM: 22-272/278.0
MSEVLKGVFVGNFR-----------------------------------------DSKDETQLGNNNITHILSI--------------------------
.||.. ....||.                                           ...  .| ...||.|...                          
pseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdf

---------------------------HDNAKPIRPDKEYLCFSADDAPGQNLIQFFSESNNFIHKCRL--------------EGGNVLIHCLAGVSRSV
                           .|. .       ||..   ..| ......| |  .||....               .|| ||.|| |||.|. 
tvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtG

TLTVAYMMTVT---DYKWEDCLRAVKTCRTV-AHPNFGFQRQLQEYEYSKL
|| .||.|       . ...... ....|   | .|....|.| |...  |
tlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 12-141 3.2e-22 72.6 In-house 15-146 (148) alignment 
Range on Protein: 12-141
Range on HMM: 15-146/148.0
VFVGNFRDSKDETQLGNNNITHILSIHDNAKPIRPDK--EYLCFSADDAPGQNLIQFFSESNNFIHKCRLEGGNVLIHCLAGVSRSVTLTVAYMMTVTDY
.|.|. .   |  .| . ..|.| .   . . .  ..  |||  . || | ..| ..| .  .|..| . ||. ||.|.  |||||  |......   . 
LFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfkrv

KWEDCLRAVKTCRTVAHPNFGFQRQLQEYEYS
  .. | .||  |   .|| || .||.|.| .
slkealalvkskrryvdpnlgfLkqLaeleqa
0036282 (Phosphotyrosine protein) phosphatases II 4-139 4.2e-22 74.1 In-house 11-166 (174) alignment 
Range on Protein: 4-139
Range on HMM: 11-166/174.0
GMSEVLKGVFVGNFRDSkDETQLGNNNITHILSIHDNAK----------------PIRPDKEYLCFSADDAPGQNLIQfFSESNNFIHKCRLE--GGNVL
..|........|..  . .  .| ...||....  .                   . | . .||..  .|    .| . . |  .|......|  || ||
dlsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvl

IHCLAGVSRSVTLTVAYMMTVTDY-KWEDCLRAVKTCR---TVAHPNFGFQRQLQEYE
.|| |||.|. || .||.| .  . . .| |. |...|     . ..... |.|...|
VHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfe
0045450 (Phosphotyrosine protein) phosphatases II 26-140 6.6e-22 74.1 In-house 127-301 (307) alignment 
Range on Protein: 26-140
Range on HMM: 127-301/307.0
LGNNNITHILSIHDNAKP-----------------------------IRPDKEYLCFSADDA-----------------PGQNLIQFFSESNNFIHKCRL
| ....|.|... .                                 . ..  ....   |                  |.... ..|.|  .||...| 
lweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrk

------EGGNVLIHCLAGVSRSVTLTVAYMMTVTD--------YKWEDCLRAVKTCRTVAHPNFGFQRQLQEYEY
      .|| ||.|| |||.|. |. .||.| .          . ...... .. .|  | .|... |.|.|...
aleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeall
0040439 (Phosphotyrosine protein) phosphatases II 25-140 1e-21 73.1 In-house 73-243 (249) alignment 
Range on Protein: 25-140
Range on HMM: 73-243/249.0
QLGNNNITHILSIHDNAK--------------------------------------------PIRPDKEYLCFSADDAPGQNLIQFFSESNNFIHKCRL-
.| ...||.|... .                                                  .. ..|..   | | ... ..|..  .||...|  
mlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrka

-----EGGNVLIHCLAGVSRSVTLTVAYMM-----TVTDYKWEDCLRAVKTCRTVAHPNFGFQRQLQEYEY
     .|| ||.|| |||.|. |. .||.|     .  ..  |.... ....|  | .|... |.|.|...
leelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeall
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 48-139 7e-21 67.8 In-house 47-138 (145) alignment 
Range on Protein: 48-139
Range on HMM: 47-138/145.0
KEYLCFSADDAPGQNLIQFFSESNNFIHKCRLEGGNVLIHCLAGVSRSVTLTVAYMMTVTDYKWEDCLRAVKTCRTVAHPNFGFQRQLQEYE
 | |  .|.|    .| | | |  .|| | . ||  |..||.||||||||..||..|   .    .  | |.. |  | ||  | ..| . |
ieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkycnmtlseaarqvrsnrllaypnvtflknllnle
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 11-141 7.6e-21 68.0 In-house 9-151 (154) alignment 
Range on Protein: 11-141
Range on HMM: 9-151/154.0
GVFVGNFRDSKDETQLGNNNITHILSIHDNAKPIRPDK----------EYLCFSADDAPGQNLIQFFSESNNFIHKCR--LEGGNVLIHCLAGVSRSVTL
 .... |  . .  .| ..||..|| .    . . .|.          |||     | . ...|. .. . .||..    .| ..||.|. .||||| .|
flyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaal

TVAYMMTVTDYKWEDCLRAVKTCRTVAHPNFGFQRQLQEYEYS
 ..|.|      .  .|  .| .| . .|| || .||. .|  
lisylmdklkislslalellkdsryiikPnqGflkqleifeke
0042113 (Phosphotyrosine protein) phosphatases II 7-140 2.2e-20 68.6 In-house 49-240 (245) alignment 
Range on Protein: 7-140
Range on HMM: 49-240/245.0
EVLKGVFVGNFRDSKDET----QLGNNNITHILSIHD-----------------------------------------------NAKPIRPDKEYLCFSA
.. ........  ...      .| ...||.|... .                                                 .. | .  |.... 
ritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpw

DDAPGQNLIQFFSESNNFIHKCRL--EGGNVLIHCLAGVSRSVTLTVAYMM-----TVTDYKWEDCLRAVKTCRTVAHPNFGFQRQLQEYEY
.| .  .|.. . .  .|..|..   ..| ||.|| |||.|. |. .||.|     .  .. .|.... .. .|  | ..... |.|.|...
pdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall
0040438 (Phosphotyrosine protein) phosphatases II 28-144 3.1e-19 64.8 In-house 108-277 (317) alignment 
Range on Protein: 28-144
Range on HMM: 108-277/317.0
NNNITHILSIHDNAKP----------------------------IRPDKEYLCFSADDA----------------PGQNLIQFFSESNNFIHKCRLE---
....|.|... .   .                              .. .....   |                 | ... . ...  .|....|     
eqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealed

-GGNVLIHCLAGVSRSVTLTVAYMM-----TVTDYKWEDCLRAVKTCRTVAHPNFGFQRQLQEYEYSKLA
 || ||.|| |||.|. |. .||.|     .  .. .|.... .. .|  | ..... |.| ....  | 
pggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylk
subfamily_STYXL1_pd Subfamily STYXL1 8-142 1.1e-18 61.0 In-house 14-153 (157) alignment 
Range on Protein: 8-142
Range on HMM: 14-153/157.0
VLK-GVFVGNFRDSKDETQLGNNNITHILSIHDNAKPIRP---D-KEYLCFSADDAPGQNLIQFFSESNNFIHKCRLEGGNVLIHCLAGVSRSVTLTVAY
||   ...||........   .  .   . .  .|...     |  . |  . .| .  .|.....|  .||.| . ||  ||.    |.|||... .||
vlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiay

MMTVTDYKWEDCLRAVKTCRTVAHPNFGFQRQLQEYEYSK
.|   . . ....  .| |.   .|| .|  ||.|.| . 
lmyskkitlkkaykylkkCkenvkPnrafveqlseWekql
0051082 (Phosphotyrosine protein) phosphatases II 5-138 4.2e-18 60.8 In-house 8-149 (151) alignment 
Range on Protein: 5-138
Range on HMM: 8-149/151.0
MSEVLKGVFVGNFRDSKDETQLGNNNITHILSIHDNA---KPIRP----DKEYLCFSADDAPGQNLIQFFSESNNFIHKCRLE-GGNVLIHCLAGVSRSV
.| |  |......  . .  .| ...|..|... .     .  ..    . |.|..  .| | ..| ..| . ..|.....   .|.||.|| ||..|. 
fsyvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTG

TLTVAYMMTvTDYKWEDCLRAVKTCRT-VAHPNFGFQRQLQEY
|| ..|.|   .. .|..|. .. .|. |  || .|. ||...
tlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfal
0039614 (Phosphotyrosine protein) phosphatases II 27-144 5.1e-18 61.0 In-house 167-290 (297) alignment 
Range on Protein: 27-144
Range on HMM: 167-290/297.0
GNNNITHILSIHdnAKPIRPDKEYLCFSADDAPGQNLIQFFSESNNFIHKCRL---EGGNVLIHCLAGVSRSVTLTVAYMM-----TVTDYKWEDCLRAV
.. .....   .   .. |  . .....  |    .... . |  .......    .|| ||.|| |||.|. |. .||.|     .  .. ...... .
dgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkel

KTCRTVAHPNFGFQRQLQEYEYSKLA
. .|  | ..... |.|.....  | 
reqRpgavqtpsqyrflydallellk
0038934 (Phosphotyrosine protein) phosphatases II 45-139 5.9e-17 57.4 In-house 77-173 (194) alignment 
Range on Protein: 45-139
Range on HMM: 77-173/194.0
RPDKEYLCFSADD---APGQNLIQFFSESNNFIHKcRLEGGNVLIHCLAGVSRSVTLTVAYMMTVTDYKWEDCLRAVKTCRTVAHPNFGFQRQLQEYE
. . ||| .   |   .| ..... | .  ..... . .|| |..|| ||..|. || .||.. . ... |.... .. .|  | || .. ..|... 
kagieylklpfpddgtvPsleillrfldlvdefln.edpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkry
0036941 (Phosphotyrosine protein) phosphatases II 48-145 7.6e-16 53.7 In-house 168-279 (297) alignment 
Range on Protein: 48-145
Range on HMM: 168-279/297.0
KEYLCFSADDAPGQNLIQFFSESNNFIHKCRL------EGGNVLIHCLAGVSRSVTLTVAYMM--------TVTDYKWEDCLRAVKTCRTVAHPNFGFQR
..   |   . |  .. . ...  .||...|       .|| ||.|| |||.|| |. .|..|        .   .   .... ....|  | ..... |
rtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyr

QLQEYEYSKLAE
.| |...  |  
flyeallellkk
0051429 (Phosphotyrosine protein) phosphatases II 12-144 1e-15 53.6 In-house 24-226 (272) alignment 
Range on Protein: 12-144
Range on HMM: 24-226/272.0
VFVGNFR---DSKDETQLGNNNITHILSIHDNA-------KPIRPDKEYLCFSADDAPGQNLIQFF----------------------------------
.. ...    . .|  .| ...|..|... .          .  |. .||...  |   .   ...                                  
lyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevm

--------------SESNNFIHKCRLeGGNVLIHCLAGVSRSVTLTVAYMMTvTDYK--------------WEDCLRAVKTCRTVAHPNFGFQRQLQEYE
              ..  .... ..  ||.||.|| ||..|. |. .....   .                .|.... .. .|  |... .. ..|.|..
hlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeal

YSKLA
   | 
lellr
0043336 (Phosphotyrosine protein) phosphatases II 26-139 1.7e-14 49.4 In-house 154-273 (278) alignment 
Range on Protein: 26-139
Range on HMM: 154-273/278.0
LGNNNITHILSIHDNAKPIRPDKEYLCFSADDAPGQ-NLIQFFSESNNFIHKCRLEGGNVLIHCLAGVSRSVTLTVAYMM-----TVTDYKWEDCLRAVK
|..  ....   .   .. |    | ...  |     .| ....  . ...... ..| ||.|| |||.|. |. ..|..     .   .  |.... ..
lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelr

TCRTVAHPNFGFQRQLQEYE
..|  | ... . |.| |..
eqRpgavqtpsqyrflyeal
subfamily_PTPMT1_pd Subfamily PTPMT1 64-141 1.4e-12 42.4 In-house 90-167 (171) alignment 
Range on Protein: 64-141
Range on HMM: 90-167/171.0
IQFFSESNNFIHKCRLEGGNVLIHCLAGVSRSVTLTVAYMMTVTDYKWEDCLRAVKTCRTVAHPNFGFQRQLQEYEYS
..  ... .||.| . .|  | .|| || .|| ||  .|.|. .  . |. |.|.|..|   . .   ...||||| .
leklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeek
0047943 (Phosphotyrosine protein) phosphatases II 23-137 1.5e-12 43.0 In-house 144-266 (273) alignment 
Range on Protein: 23-137
Range on HMM: 144-266/273.0
ETQLGNNNITHILSIHDNAKPIRPDKEYLCFSADDAPGQNLIQFFSESNNFIHKCRL---EGGNVLIHCLAGVSRSVTLTVAYMM-----TVTDYKWEDC
|.. ..  ....   . . .  |  . .....  |      .. . |  ....|..    ..| |..|| |||.|. |. .....     .      ...
eetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvlea

LRAVKTCRTVAHPNFGFQRQLQE
.. ....|  . ... . |.| |
vkllrsqRpgmvqtpeqyrflye
subfamily_MSG5_pd Subfamily MSG5 68-140 1.1e-11 38.2 In-house 86-158 (165) alignment 
Range on Protein: 68-140
Range on HMM: 86-158/165.0
SESNNFIHKCRLEGGNVLIHCLAGVSRSVTLTVAYMMTVTDYKWEDCLRAVKTCRTVAHPNFGFQRQLQEYEY
|.  . ||  . ..  .|.||  |.||| .| |||.|   .   .|.   .|.      |..|.  || |.| 
srltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmewev
0050432 (Phosphotyrosine protein) phosphatases II 48-129 8e-11 37.3 In-house 200-285 (308) alignment 
Range on Protein: 48-129
Range on HMM: 200-285/308.0
KEYLCFSADDAPG----QNLIQFFSESNNFIhkcrlEGGNVLIHCLAGVSRSVTLTVAYMM-----TVTDYKWEDCLRAVKTCRTVAHPNF
. . . .  |       . |..|. . ....     .||....|| |||.|. |. .....     .     ...... ....|  . ...
thfhytnWpdhgvPpspeilldflelvrksl.....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp
0051299 (Phosphotyrosine protein) phosphatases II 30-129 1.3e-10 36.7 In-house 163-272 (288) alignment 
Range on Protein: 30-129
Range on HMM: 163-272/288.0
NITHILSIHD----NAKPIRPDKEYLCFSADDAPGQN-LIQFFSESNNFIHKCRLEGGNVLIHCLAGVSRSVTLTVAYMM-----TVTDYKWEDCLRAVK
 ....   .       .  |  . . ...  |    . . ....  . ......  || |..|| |||.|. |. .....     .     ... .. ..
tvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlr

TCRTVAHPNF
..|  . ...
eqRpgmvqtp
0048567 (Phosphotyrosine protein) phosphatases II 43-132 1.3e-10 35.9 In-house 32-130 (157) alignment 
Range on Protein: 43-132
Range on HMM: 32-130/157.0
PIRPDK--EYLCFSADDAPGQ--NLIQFFSESNNFIHKCRLEGGNVLIHCLAGV---SRSVTLTVAYMMTVTDYKWEDCLRAVKTCR--TVAHPNFGFQ
..  |    |. | .|. |     |..|.   |.|.. ..|.|. . .|| ||    .|..||  .|.. . ..  |.... .. .|   | ..  .. 
yFsiddglvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasyl
0046845 (Phosphotyrosine protein) phosphatases II 41-128 3e-10 35.4 In-house 161-259 (284) alignment 
Range on Protein: 41-128
Range on HMM: 161-259/284.0
AKPIRPDKEYLCF--SADDAP--GQNLIQFFSESNNFIHKcRLEGGNVLIHCLAGVSRSVTLTVAYMMTVT--------DYKWEDCLRAVKTCRTVAHPN
 .. |  . . ..    ...|   ..|..|. . .... . .  || ...|| |||.|. |. .....            .  ..... ....|  .  .
tgesrtvthfhytswpdhgvppspedlleflrlvrellen.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqt
PTPc_DSPc_SM00012 54-124 8.6e-10 34.1 In-house 19-82 (105) alignment 
Range on Protein: 54-124
Range on HMM: 19-82/105.0
SaddapgQNLIQFFSESNNFIHKCRLeGGNVLIHCLAGVSRSVTLTVAYMMTVTDYKWEDCLRAVKTCRTV
|      ....... . ... .|.   ...|..|| |||.|. |.......    .|.....   .... .
s......dsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkel
subfamily_DSP11_pd Subfamily DSP11 59-124 7.6e-07 23.2 In-house 93-159 (178) alignment 
Range on Protein: 59-124
Range on HMM: 93-159/178.0
PGQNLIQFF-SESNNFIHKCRLEGGNVLIHCLAGVSRSVTLTVAYMMTVTDYKWEDCLRAVKTCRTV
| ..|.. | .. ..|..|.  ..  . .||  || |.  |   |.. |..|. || ..| ...|  
pkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGh
subfamily_CDC14_pd Subfamily CDC14 72-123 2.3e-06 21.7 In-house 254-305 (328) alignment 
Range on Protein: 72-123
Range on HMM: 254-305/328.0
NFIHKCRLEGGNVLIHCLAGVSRSVTLTVAYMMTVTDYKWEDCLRAVKTCRT
.|.. .    |.. .|| ||. |  ||  .|.|    .  ....  .. || 
kfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrP
Y_phosphatase Protein-tyrosine phosphatase 72-139 7.6e-06 20.9 Pfam-A 157-227 (235) alignment 
Range on Protein: 72-139
Range on HMM: 157-227/235.0
NFIHKCRLEG----GNVLIHCLAGVSRSVTLTVAYMMTVTDYKwEDCLRAVKTCRTVAHPNFGFQRQLQEYE
..|.|.. .     |.|..|| |||.|. |. .. ..     . |...  ....... .  .|   .|..|.
dlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqlea.eeevdvlqivkelRkqRpgmvqsleqYi
Y_phosphatase Protein-tyrosine phosphatase 72-139 7.6e-06 20.9 In-house 157-227 (235) alignment 
Range on Protein: 72-139
Range on HMM: 157-227/235.0
NFIHKCRLEG----GNVLIHCLAGVSRSVTLTVAYMMTVTDYKwEDCLRAVKTCRTVAHPNFGFQRQLQEYE
..|.|.. .     |.|..|| |||.|. |. .. ..     . |...  ....... .  .|   .|..|.
dlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqlea.eeevdvlqivkelRkqRpgmvqsleqYi