Gene DSP6 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP6
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP019_AA protein Get Run
SpurP019_AA_182-326 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP6_pd Subfamily DSP6 181-327 3.5e-82 267.6 In-house 10-157 (158) alignment 
Range on Protein: 181-327
Range on HMM: 10-157/158.0
DNRYPAQILPYLYLGTKQDCENFELFSKLRIRYVLNVTPNIPNCFEDNG-IKYMQIPIMDHWSQNLAAFFPEAIEFIDEARRAKSGILVHCLAGVSRSVT
....|..|||.||||...|..|.|...||.|.||||||.|.||.||..| .||.||||.||.|||||.|||||||||||||..||..|||||||.|||||
eaefpveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvt

VTVAYLMQKLCLSLNDAYDFVKERKSNISPNFNFMGQLKDFEQKLSTS
||.||||.||.||||||||.||.|||||||||||||||.|||..|..|
vtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldferslrls
subfamily_DSP10_pd Subfamily DSP10 180-327 4e-61 199.5 In-house 9-156 (159) alignment 
Range on Protein: 180-327
Range on HMM: 9-156/159.0
LDNRYPAQILPYLYLGTKQDCENFELFSKLRIRYVLNVTPNIPNCFEDNGIKYMQIPIMDHWSQNLAAFFPEAIEFIDEARRAKSGILVHCLAGVSRSVT
...   .|.||.|.|| ..| .. ... .|.| .|||||...|| ||....||..||. |  .|||   | ||.|||.|||.  | .|||| ||.|||.|
ietapasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsat

VTVAYLMQKLCLSLNDAYDFVKERKSNISPNFNFMGQLKDFEQKLSTS
|..||||..| |||||||.||||... ||||.||||||..||..|. |
vviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnks
subfamily_DSP8_pd Subfamily DSP8 182-326 1.6e-45 148.5 In-house 12-156 (159) alignment 
Range on Protein: 182-326
Range on HMM: 12-156/159.0
NRYPAQILPYLYLGTKQDCENFELFSKLRIRYVLNVTPNIPNCFEDNGIKYMQIPIMDHWSQNLAAFFPEAIEFIDEARRAKSGILVHCLAGVSRSVTVT
.  | .||..||||...|  . ||.||| | ||||.  . |.  | .  |....|. |. . .|  .|....|||| |..... .|||.||| ||| || 
dvgptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatva

VAYLMQKLCLSLNDAYDFVKERKSNISPNFNFMGQLKDFEQKLST
.||.|..| .||..|| ||||..  ||||.||.||| ..|..| .
iayimktlemsldeayrfvkekrptispnlnflgqLleyekelkl
PTPc_motif_SM00404 185-323 1.8e-45 149.3 In-house 2-140 (140) alignment 
Range on Protein: 185-323
Range on HMM: 2-140/140.0
PAQILPYLYLGTKQDCENFELFSKLRIRYVLNVTPNIPNCFEDNGIKYMQIPIMDHWSQNLAAFFPEAIEFIDEARRAKSGILVHCLAGVSRSVTVTVAY
| .|||.||||.|.. .| .| .||.|..|.||| ....  |..|....|||..|. ...|.........||..|.. .  .|||| ||||||.|...||
psrilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaY

LMQKLCLSLNDAYDFVKERKSNISPNFNFMGQLKDFEQK
||..  |||..||.|||||...||||.||. || ..|.|
lmryrqlslaeayefvkerRpiispnlnfvrqLieyekk
subfamily_DSP1_pd Subfamily DSP1 183-326 1.4e-44 146.1 In-house 14-158 (163) alignment 
Range on Protein: 183-326
Range on HMM: 14-158/163.0
RY-PAQ-ILPYLYLGTKQDCENFELFSKLRIRYVLNVTPNIPNCFEDnGIKYMQIPIMDHWSQNLAAFFPEAIEFIDEARRAKSGILVHCLAGVSRSVTV
 | | . ||..||||....  | |. ..|.|  .|||. ...| |||   .|..... |. .... . | |.||||||.....  .|.|| ||.||| |.
lydPvekildfLylGsetvasnleiLkslgitailnvskeldnvfed.lfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstl

TVAYLMQKLCLSLNDAYDFVKERKSNISPNFNFMGQLKDFEQKLST
 .||||..  .||..|.||||.|.| ||||..|..||...|.|| .
claylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekklll
0044763 (Phosphotyrosine protein) phosphatases II 173-324 2.5e-42 139.9 In-house 11-170 (178) alignment 
Range on Protein: 173-324
Range on HMM: 11-170/178.0
LVQAETPLDNRYPAQILPYLYLGTKQDCENFELFSKLRIRYVLNVTPN--------IPNCFEDNGIKYMQIPIMDHWSQNLAAFFPEAIEFIDEAR-RAK
 .. .   |. .. .|||.||||.  . ...||. .| |....|.|..        .|  .|..||.|..||| ||  ..| ..|.|..|||.||. . .
nleglersdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekg

SGILVHCLAGVSRSVTVTVAYLMQKLCLSLNDAYDFVKERKSnISPNFNFMGQLKDFEQKL
. .|||| |||.|| |. .|||| || |||..|...|.||.. |.||.... ||..||..|
gpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrl
DSPc Dual specificity phosphatase, catalytic domain 192-323 2.6e-42 138.8 Pfam-A 1-133 (133) alignment 
Range on Protein: 192-323
Range on HMM: 1-133/133.0
LYLGTKQDCEnFELFSKLRIRYVLNVTPNIPN--CFEDNGIKYMQIPIMDHWSQNLAAFFPEAIEFIDEARRAKSGILVHCLAGVSRSVTVTVAYLMQKL
||||.|.. .  .| .|| | .|.||| ..||  ..... |.|..||..|...........||.|||..|.. .  .|||| ||.||| |...||||.. 
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

CLSLNDAYDFVKERKSNISPNFNFMGQLKDFEQK
.||||.||.|||||.|.||||..|..|| ..|.|
nlslneAyefvkerrskispnagflrqLleyerk
DSPc Dual specificity phosphatase, catalytic domain 192-323 2.6e-42 138.8 In-house 1-133 (133) alignment 
Range on Protein: 192-323
Range on HMM: 1-133/133.0
LYLGTKQDCEnFELFSKLRIRYVLNVTPNIPN--CFEDNGIKYMQIPIMDHWSQNLAAFFPEAIEFIDEARRAKSGILVHCLAGVSRSVTVTVAYLMQKL
||||.|.. .  .| .|| | .|.||| ..||  ..... |.|..||..|...........||.|||..|.. .  .|||| ||.||| |...||||.. 
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

CLSLNDAYDFVKERKSNISPNFNFMGQLKDFEQK
.||||.||.|||||.|.||||..|..|| ..|.|
nlslneAyefvkerrskispnagflrqLleyerk
subfamily_DSP19_pd Subfamily DSP19 186-324 6.1e-39 127.8 In-house 13-150 (152) alignment 
Range on Protein: 186-324
Range on HMM: 13-150/152.0
AQILPYLYLGTKQDCENFELFSKLRIRYVLNVTPNIPNCFEDNgIKYMQIPIMDHWSQNLAAFFPEAIEFIDEARRAKSGILVHCLAGVSRSVTVTVAYL
... |.|||| ..  .. | ... .| ..|||. ..||.| .. ..|..|.|.|.  ..| ....||..||.|||...  .|||| ||||||..| .|||
geveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkd.ftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviayl

MQKLCLSLNDAYDFVKERKSNISPNFNFMGQLKDFEQKL
|.|  |||..|.. |.| . .|.||  |. |||..|..|
mkkeelsleealelvrearpcikPneGFikqLkeyeael
subfamily_Slingshot_pd Subfamily Slingshot 184-327 5e-38 124.1 In-house 18-160 (169) alignment 
Range on Protein: 184-327
Range on HMM: 18-160/169.0
YPAQILPYLYLGTKQDCENFELFSKLRIRYVLNVTPNIPNCFEDNgIKYMQIPIMDHWSQNLAAFFPEAIEFIDEARRAKSGILVHCLAGVSRSVTVTVA
 ...|  ..|||.  .  |.| ... ...|.|||| .| | |... ..|..| ..|. ...| ... |. .||..|....| .||||  ||||| .. .|
saskifdhvylGsewnasnleelkengveyilnvtkeidnffpek.feylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastvia

YLMQKLCLSLNDAYDFVKERKSNISPNFNFMGQLKDFEQKLSTS
| |..  |||..|...||||.| | || .|. ||. .|  |..|
yamkeyglsleealeyvkerrsvikPnkgflkqleeyeGileas
0048076 (Phosphotyrosine protein) phosphatases II 184-324 2.8e-37 122.9 In-house 3-142 (145) alignment 
Range on Protein: 184-324
Range on HMM: 3-142/145.0
YPAQILPYLYLGTKQDCENFELFSKLRIRYVLNVTPNIPNCFeDNGIKYMQIPIMDHWSQNLAAFFPEAIEFIDEARRAKSGILVHCLAGVSRSVTVTVA
.|..|||.||||   . ...||. .| |..|||.|....... ..||.|...|. ||  ..|.....|..|||.||....  .|||| |||.|. |. .|
wpseilpglylgslptaldlellkdlgittvlnltselelle.rlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaa

YLMQKLCLSLNDAYDFVKERKSNISPNFNFMGQLKDFEQKL
||| .| .|| .|...|... ... ||.... .|..||..|
ylmlllgvsleealelvrsqrpgavpnpgqlrflyefelel
subfamily_DSP12_pd Subfamily DSP12 187-323 7.7e-37 121.1 In-house 4-142 (155) alignment 
Range on Protein: 187-323
Range on HMM: 4-142/155.0
QILPYLYLGTKQDCENFELFSKLRIRYVLNVTPN-IPNCFEDNGIKY-MQIPIMDHWSQNLAAFFPEAIEFIDEARRAKSGILVHCLAGVSRSVTVTVAY
.||| ||||. .. .. || ..| |  || |. . .|.  ...| ..  .|.|.|. ....  ...||..||.||.  .  .|||| ||||||||. .||
rilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAY

LMQKLCLSLNDAYDFVKERKSNISPNFNFMGQLKDFEQK
||.|  |||..|...||| |..|.|| .|. ||| ||. 
lmkkeklslekAlklvkekkpeiepNegFleQLklfekm
0048179 (Phosphotyrosine protein) phosphatases II 184-324 8.9e-37 121.3 In-house 3-144 (144) alignment 
Range on Protein: 184-324
Range on HMM: 3-144/144.0
YPAQILPYLYLGTKQDCENFELFSKLRIRYVLNVTPN-IPNCFEDNGIKYMQIPIMDHWSQNLAAFFPEAIEFIDEARRAKSGILVHCLAGVSRSVTVTV
.|..|||.||||   . ...||. || |..|.|.|..  |...|..||.|...|. ||   .|.....|..|||.||.. .  .|||| |||.|. |. .
npseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlva

AYLMQKLCLSLNDAYDFVKERKSNISPNFNFMGQLKDFEQKL
|||| || |||..|...|..| ... ||.... .|...|..|
aylmkklglsleealalvrsrrpgavpnpgqlrfLleyekll
subfamily_DSP14_pd Subfamily DSP14 186-326 1.2e-36 120.0 In-house 8-146 (157) alignment 
Range on Protein: 186-326
Range on HMM: 8-146/157.0
AQILPYLYLGtKQDCENFELFSKLRIRYVLNVTPNIPNcFEDNGIKYMQIPIMDHWSQNLAAFFPEAIEFIDEARRAKSGILVHCLAGVSRSVTVTVAYL
.|| |.|.|.  . . . ||..| .|  ..|||...||  . ..|.....|. |. ...||..| |... |.|.....  .|||| |||||| ....|||
sqitpsLfls.gvaalskellkkkkitliinvtvelpn.tklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclayl

MQKLCLSLNDAYDFVKERKSNISPNFNFMGQLKDFEQKLST
|.  .|||..||  ||.... |.||  |  || |.|.||  
mkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkg
subfamily_DSP15_pd Subfamily DSP15 187-323 8.3e-36 117.3 In-house 4-138 (151) alignment 
Range on Protein: 187-323
Range on HMM: 4-138/151.0
QILPYLYLGTKQDCENFELFSKLRIRYVLNVTPNIPNCFEDngIKYMQIPIMDHWSQNLAAFFPEAIEFIDEARRAKSGILVHCLAGVSRSVTVTVAYLM
..|| ||||  .| .. || .. .|  .|.|  |  ....|  |.|  |.. |  |..|  || |..||| ..|  . ..|||||||||||||..|||||
kvlpglylgnfrdskdeelLkeknithilsvhdnakkllkd..ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlm

QKLCLSLNDAYDFVKERKSNISPNFNFMGQLKDFEQK
  . |. .|| ...|...|   ||| |  |||..|..
tvtelnwrdalevikaaRsvanPnfGfkrqlkeyekt
0043147 (Phosphotyrosine protein) phosphatases II 184-324 9.9e-36 118.4 In-house 18-160 (172) alignment 
Range on Protein: 184-324
Range on HMM: 18-160/172.0
YPAQILPYLYLGTKQDCENFELFSKLRIRYVLNVTPN--IPNCFEDNGIKYMQIPIMDHWSQnLAAFFPEAIEFIDE--ARRAKSGILVHCLAGVSRSVT
 | .........   . ...... .| |....|.|.   .| ..|..||.|. .|. ||. . |.....|..|||||  |.. .  .|||| |||.|..|
ipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgt

VTVAYLMQkLCLSLNDAYDFVKERKSNISPNFNFMGQLKDFEQKL
. .||||. |.||| .|...|.|.......|.... .|..||..|
lvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfekll
0041856 (Phosphotyrosine protein) phosphatases II 181-324 3.1e-34 113.5 In-house 15-172 (182) alignment 
Range on Protein: 181-324
Range on HMM: 15-172/182.0
DNRYPAQILPYLYLGTKQD--------------CENFELFSKLRIRYVLNVTPNI--PNCFEDNGIKYMQIPIMDHWSQNlaafFPEAIEFIDEARRAKS
 .|.. .|...||||   .               ...... .|.|....|.|.    |. .|..||.|...|. ||   .    ..|...||.|... . 
hsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd....ldelldfieevleegg

GILVHCLAGVSRSVTVTVAYLMQKLCLSLNDAYDFVKERKS--NISPNFNFMGQLKDFEQKL
 .|||| |||.|. |. .|||| || .|| .|...|..|..   |.||..|. ||. .| .|
pvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallelll
0049772 (Phosphotyrosine protein) phosphatases II 204-324 8e-34 113.2 In-house 167-273 (314) alignment 
Range on Protein: 204-324
Range on HMM: 167-273/314.0
ElfsklriryvlnvtPNI--PNCFEDNGIKYMQIPIMDhWSQNLAAFFPEAIEFIDEArRAKSGILVHCLAGVSRSVT-VTVAYLMQKLCLSLNDAYDFV
.              . .  |. ||..||||..||. | .|..| ..|.|..|||.|| .... .|||| ||..|. | |..|||| .| .||..|...|
k..............eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedv

KERKSnISPNFNFMGQLKDFEQKL
... . |.||..|. ||...|..|
rlkRp.inpnpgfieqleqyefil
0046846 (Phosphotyrosine protein) phosphatases II 179-324 4.3e-33 109.9 In-house 6-172 (176) alignment 
Range on Protein: 179-324
Range on HMM: 6-172/176.0
PLDNRYPAQILPYLYLGTKQ----------DCENFELFSKLRIRYVLNVT----------PNIPNCFEDNGIKYMQIPIMDHWSQNLaAFFPEAIEFIDE
. .. .. .|...|.|| .             ...|.. .|.|..|.|.|          ||... .|..||.|...|. ||.  .| . ..|..|||.|
lgldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefire

ARRAKSGILVHCLAGVSRSVTVTVAYLMQK-LCLSLNDAYDFVKERKS-NISPNFNFMGQLKDFEQKL
|....  .|||| ||..|. |. .|||...  .||...|...|.|... .. ...... .|..||..|
alkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefelll
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 183-323 2.8e-31 102.0 In-house 5-146 (148) alignment 
Range on Protein: 183-323
Range on HMM: 5-146/148.0
RYPAQILP-YLYLGTKQDCENFELFSKLRIRYVLNVTPNIPNCFEDNGIKYMQIPIMDHWSQNLAAFFPEAIEFIDEARRAKSGILVHCLAGVSRSVTVT
..|..| . .|.|| |.   ..|   .| .  . | | . .| ... ||.|..... |.  ..| |.|...|.|...|. .   .|||.  |||||  ..
tfpseikdafLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssala

VAYLMQKLCLSLNDAYDFVKERKSNISPNFNFMGQLKDFEQK
...|..    ||..|...||...  . ||  |. || ..||.
llwlidfkrvslkealalvkskrryvdpnlgfLkqLaeleqa
PTEN_1 154-325 3.9e-31 103.4 In-house 9-192 (196) alignment 
Range on Protein: 154-325
Range on HMM: 9-192/196.0
SDECSLTDLGFDRLKIETTLVQAETPLDNR-YPAQILPYLYLGTKQDC-ENFELFSKLRIRYVLNVTPNIPN--------CFEDNGIKYMQIPIMDHWSQ
|..... .  . .|.. |. ..| .   .| .. .| . ||.|   |  .... . .  |. |.|...  ..         |...|..| ..||.||. .
skknlalptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgap

NLAAFFPEAIEFIDEARRAKS--GILVHCLAGVSRSVTVTVAYLMQKLCLSLNDAYDFVKERKSNISPNFNFMGQLKDFEQKLS
.|. .| .. .||. ......   .|||| ||..||.||  ||||.|  |. ..| ..|.|. ....||  .. .|. ....| 
slselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaell
0049260 (Phosphotyrosine protein) phosphatases II 185-324 5.2e-31 102.8 In-house 8-149 (152) alignment 
Range on Protein: 185-324
Range on HMM: 8-149/152.0
PAQILPYLYLGTKQDCENFELFSKLRIRYVLNVTPNIPN--CFEDNGIKYMQIPIMDHWSQNLAAFFPEAIEFIDE-ARRAKSGILVHCLAGVSRSVTVT
| ........|     ...... .| |......|   ..  ......|.|...|. ||. ..|. .......||.. |.. .  .|||| |||.|. |. 
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlv

VAYLMQkLCLSLNDAYDFVKERKSNISPNFNFMGQLKDFEQKL
.||||  | .|| .|...|.|..... ||.... .|..||..|
aaylml.lgvsleeavalvrekRpgavpnpgqlrflyefekll
subfamily_LRR-DSP_pd Subfamily LRR-DSP 175-326 1.5e-30 100.2 In-house 110-260 (263) alignment 
Range on Protein: 175-326
Range on HMM: 110-260/263.0
QAETPLDNRYPAQILPYLYLGTKQDCENFELFSKLRIRYVLNVTPNIPNCFEDnGIKYMQI-PIMDHWSQNLAAFFPEAIEFIDEARRaKSGILVHCLAG
.    |    | .|.. |.||...   |  .. .| . ..|    ..   | .   ||. |  | |    ..  .| |   ||.| |. | |.|||| ||
eslitlvssvPdeiidklflGgldsannksilkdlgvthillavadfePlfPk.lfkylsiddiedvdeadisqhfeetnafieeGrk.kGGvlvhcraG

VSRSVTVTVAYLMQKLCLSLNDAYDFVKERKSNISPNFNFMGQLKDFEQKLST
|||| |....|||.|  | ...|.|.|......| ||  |. ||| .|.||..
vsrsstlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklfc
0036282 (Phosphotyrosine protein) phosphatases II 188-325 8.8e-30 99.1 In-house 15-170 (174) alignment 
Range on Protein: 188-325
Range on HMM: 15-170/174.0
ILPYLYLGTKQDCeNFELFSKLRIRYVLNVTPNIP--------------NCFEDNGIKYMQIPIMDHWSQNLAAfFPEAIEFIDEARRA--KSGILVHCL
|.|.|..|    . ..|.. .|.|..|..... ..              . .|..||.|...|. ||   .|.  . |...|..||.    .  .|||| 
itprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCs

AGVSRSVTVTVAYLMQKLCL-SLNDAYDFVKERK---SNISPNFNFMGQLKDFEQKLS
|||.|. |. .|||| .. | || ||.|.|.|..   ... ...... .| .||..||
aGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfeklls
subfamily_MKPLT_pd Subfamily MKPLT 183-322 7e-29 94.5 In-house 19-158 (164) alignment 
Range on Protein: 183-322
Range on HMM: 19-158/164.0
RYPAQILP-YLYLGTKQDCENFELFSKLRIRYVLNVTPNIPNCFEdNGIKYMQIPIMDHWSQNLAAFFPEAIEFIDEARRAKSGILVHCLAGVSRSVTVT
 ||. .|.  ||||  .. .| ..  .| | ...||. .  . |  . ..|.|. . |   ..|..|.  | .|. .|  .   .||||  |.||| .||
iypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafp.ksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvt

VAYLMQKLCLSLNDAYDFVKERKSNISPNFNFMGQLKDFEQ
||.|..     |..||...|||.| ..||  |. ||  ||.
vafLikskgwtlkeayeylkerrsivapnrGflkqlakfee
subfamily_MKPLV_pd Subfamily MKPLV 183-322 7e-29 94.5 In-house 19-158 (164) alignment 
Range on Protein: 183-322
Range on HMM: 19-158/164.0
RYPAQILP-YLYLGTKQDCENFELFSKLRIRYVLNVTPNIPNCFEdNGIKYMQIPIMDHWSQNLAAFFPEAIEFIDEARRAKSGILVHCLAGVSRSVTVT
 ||. .|.  ||||  .. .| ..  .| | ...||. .  . |  . ..|.|. . |   ..|..|.  | .|. .|  .   .||||  |.||| .||
iypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafp.ksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvt

VAYLMQKLCLSLNDAYDFVKERKSNISPNFNFMGQLKDFEQ
||.|..     |..||...|||.| ..||  |. ||  ||.
vafLikskgwtlkeayeylkerrsivapnrGflkqlakfee
subfamily_STYXL1_pd Subfamily STYXL1 183-325 1.3e-28 93.2 In-house 9-154 (157) alignment 
Range on Protein: 183-325
Range on HMM: 9-154/157.0
RYPAQILP-YLYLGTKQDCENFELFSKLRIRYVLNVTPNIPNCFE---DnGIKYMQIPIMDHWSQNLAAFFPEAIEFIDEARRAKSGILVHCLAGVSRSV
 || ..||  ||||. ... | ..   |... ..||. .  . ..   |   | ..|.. |.   .|  .. ||..||.. .. .. .||    |.|||.
tyPvevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvad.vakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsa

TVTVAYLMQKLCLSLNDAYDFVKERKSNISPNFNFMGQLKDFEQKLS
.| .|||| .  ..|..||...|. |.|. || .|. ||...|..|.
aviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekqll
subfamily_DSP3_pd Subfamily DSP3 187-325 1.6e-28 93.4 In-house 13-158 (162) alignment 
Range on Protein: 187-325
Range on HMM: 13-158/162.0
QILPYLYLGTKQDCENFELFSKLRIRYVLNVTPN-------IPNCFEDNGIKYMQIPIMDHWSQNLAAFFPEAIEFIDEARRA-KSGILVHCLAGVSRSV
.. | ||.| ..  .. . . || | .||| .          .. ..| .|||. ... |  . .| ..| .| .|||||    .. .|||| .||||| 
evypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsa

TVTVAYLMQKLCLSLNDAYDFVKERKsNISPNFNFMGQLKDFEQKLS
|. .|||| .  ..|..|   |.... .| ||  |. ||......|.
tlvlayLmirrkmtlveairtvrkkR.eilPneGFlkqLaeldeelk
0045098 (Phosphotyrosine protein) phosphatases II 175-324 2.3e-28 94.8 In-house 12-271 (278) alignment 
Range on Protein: 175-324
Range on HMM: 12-271/278.0
QAETPLDNRYPAQILPYLYLGTKQ-----------------------------------------DCENFELFSKLRIRYVLNVTPNI------------
. |  |   .| .|.|.|||| .                                             ..... .|.|......|. .            
efefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp

------------------------------------PNCFEDNGIKYMQI-PIMDHWSQNLA--AFFPEAIEFIDEARR--------------AKSGILV
                                    .. .| .|...... |. || . .|   ..| |..|||.||..               .  .||
eggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlV

HCLAGVSRSVTVTVAYLMQKL---CLSLNDAYDFVKERKSN-ISPNFNFMGQLKDFEQKL
|| |||.|. |. .|||| .|    ..| .|........ . . .|.... .| .|...|
HCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllel
0037934 (Phosphotyrosine protein) phosphatases II 181-323 1.5e-26 88.9 In-house 13-240 (243) alignment 
Range on Protein: 181-323
Range on HMM: 13-240/243.0
DNRYP----------------------AQILPYLYLGTK--------QDCENFELFSKLRIRYVLNVTPNI-----------------------------
.|||.                       ...|.|...           . ...... .|.|......|. .                             
knrysdilpydhsrvklegsdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseeh

---------------PNCFEDNGIKYMQIPIMDH---W-SQNLAAFFPEAIEFIDE-----ARRAKSGILVHCLAGVSRSVTVTVAYLMQKL-CLSLNDA
               .. .. ..|.|...|. ||      ..| .|. |..|||.|     |.  .. .|||| |||.|. |. .|||| .| ...| .|
lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleea

YDFVKERKSN-ISPNFNFMGQLKDFEQK
.....|.... . ...... .| .....
vkllreqRpgkavqtpsqyrflyealle
0051082 (Phosphotyrosine protein) phosphatases II 187-320 1.3e-25 85.2 In-house 10-149 (151) alignment 
Range on Protein: 187-320
Range on HMM: 10-149/151.0
QILPYLYLGTKQDCENFELFSKLRIRYVLNVTP-----NIPNCFEDNGIKYMQIPIMDHWSQNLAAFFPEAIEFIDEARRA-KSGILVHCLAGVSRSVTV
.. ..||..     ...||. .| |....|...     . |. ....||....|||.|.. ..|  .|....||......  .  .|||| ||..|. |.
yvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtl

TVAYLMQkLCLSLNDAYDFVKERKS-NISPNFNFMGQLKDF
 ..|||  | .||..|.......    . ||  |. ||...
valylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfal
0042113 (Phosphotyrosine protein) phosphatases II 187-323 2.1e-25 85.0 In-house 49-241 (245) alignment 
Range on Protein: 187-323
Range on HMM: 49-241/245.0
QILPYLYLGTKQDCENFE----LFSKLRIRYVLNVTPNI---------------------------------------------PNCFEDNGIKYMQIPI
.| | ....     |..|    .. .|.|......|.                                               .. .. ..| |...|.
ritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpw

MDHWSQNLAAFFPEAIEFIDEARR--AKSGILVHCLAGVSRSVTVTVAYLM-----QKLCLSLNDAYDFVKERKSNISPNFNFMGQLKDFEQK
 ||   .| . . ...||...|..  ..  .|||| |||.|. |. .||||       |..|| .|........... ...... .| .....
pdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 191-324 2.3e-25 82.7 In-house 9-152 (154) alignment 
Range on Protein: 191-324
Range on HMM: 9-152/154.0
YLYLGTKQDCENFELFSKLRIRYVLNVTPNIPNCFEDN--------GIKYMQIPIMDHWSQNLAAFFPEAIEFIDEAR--RAKSGILVHCLAGVSRSVTV
.||... . . |  .. . .|. .|||   |.| | |.         |.|... . |.  ...   .  | ||||.|     ....|||. .||||| ..
flyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaal

TVAYLMQKLCLSLNDAYDFVKERKSNISPNFNFMGQLKDFEQKL
 ..|||.|| .||  |. ..|. .  |.||  |. ||. ||..|
lisylmdklkislslalellkdsryiikPnqGflkqleifekel
0040439 (Phosphotyrosine protein) phosphatases II 201-323 6.4e-25 83.6 In-house 69-244 (249) alignment 
Range on Protein: 201-323
Range on HMM: 69-244/249.0
ENFELFSKLRIRYVLNVTPNIPNC------------------------------------------FEDNGIKYMQIPIMDHWSQNLAAFFPEAIEFIDE
 ..... .|.|......|.  ..                                            ... .....|.. |   ...  .|.....||..
dfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfiea

ARR------AKSGILVHCLAGVSRSVTVTVAYLM-----QKLCLSLNDAYDFVKERKSNISPNFNFMGQLKDFEQK
.|        .. .|||| |||.|. |. .||||      .|...| .|........... .|.... .| .....
vrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle
0038934 (Phosphotyrosine protein) phosphatases II 177-326 1.7e-24 82.0 In-house 24-178 (194) alignment 
Range on Protein: 177-326
Range on HMM: 24-178/194.0
ETPLDNRYPAQILPYLYLGTKQDCENFELFsKLRIRYVLNVTPNI----PNCFEDNGIKYMQIPIMDHWS----QNLAAFFPEAIEFIDEarRAKSGILV
 .||....  .| ... .. .  .. ..|. . ....|...| .     |. ||..||.|...|..|...    ..|  |.  . ||..|   ..  ..|
kvPlsgsldkyieelyrfspedlvrylkll.nvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflne..dpggvvaV

HCLAGVSRSVTVTVAYLMQKLCLSLNDAYDFVKERKSNISPNFNFMGQLKDFEQKLST
|| ||..|. |. .|||...|..|...|.....|.. .. || ... .|  . . |  
HCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykelrk
0045450 (Phosphotyrosine protein) phosphatases II 183-324 3.3e-24 81.6 In-house 60-303 (307) alignment 
Range on Protein: 183-324
Range on HMM: 60-303/307.0
RYPA-----------------------------QILPYLYLGTKQDCENF---------------ELFSKLRIRYVLNVTPNIPNCF-------------
||.                               . ..|.|..   . .|               ... ..........|. ... .             
rykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegee

--------------EDNGIKYMQIPIMDH-----------------WSQNLAAFFPEAIEFIDEARR------AKSGILVHCLAGVSRSVTVTVAYLMQK
              ...|........ |.                   ...  .| |...||.|.|.       .. .|||| |||.|. |. .|||| .
ltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlr

LC--------LSLNDAYDFVKERKSNISPNFNFMGQLKDFEQKL
.         ..| .|.....|..... .|.... .| .....|
qlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
0039614 (Phosphotyrosine protein) phosphatases II 203-324 1.5e-22 75.9 In-house 118-288 (297) alignment 
Range on Protein: 203-324
Range on HMM: 118-288/297.0
FELFSKLRIRYVLNVTPNIPN------------------------CFEDNGIK-----------------YMQIPIMDHWSQNLAAFFPEAIEFIDEARR
.... ..........|. ...                        .....|..                 .  ... ||   .... . |..|...||..
wrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvreala

---AKSGILVHCLAGVSRSVTVTVAYLM-----QKLCLSLNDAYDFVKERKSNISPNFNFMGQLKDFEQKL
    .  .|||| |||.|. |. .||||      . .... .|.....|..... ...... .| |....|
elpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallel
0040438 (Phosphotyrosine protein) phosphatases II 203-324 1.6e-22 75.6 In-house 103-275 (317) alignment 
Range on Protein: 203-324
Range on HMM: 103-275/317.0
FELFSKLRIRYVLNVTPNI--------------------------PNCFEDNGIKYMQIPIMDH----------------WSQNLAAFFPEAIEFIDEAR
.... ..........|.                             ...|..||.. .... |.                  ...   . . ..|....|
wrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavr

RA----KSGILVHCLAGVSRSVTVTVAYLM-----QKLCLSLNDAYDFVKERKSNISPNFNFMGQLKDFEQKL
.|    .. .|||| |||.|. |. .||||     .. .... .|.....|..... ...... .| |.....
ealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalley
subfamily_STYX_pd Subfamily STYX 187-322 1.6e-21 70.1 In-house 14-155 (166) alignment 
Range on Protein: 187-322
Range on HMM: 14-155/166.0
QILPYLYLGTKQDCE--NFELFSKLRIRYVLNVTPNIPNCF----EDNGIKYMQIPIMDHWSQNLAAFFPEAIEFIDEARRAKSGILVHCLAGVSRSVTV
.||| |.||    .    .| . |  | ... .  ||   .     .. ..|. . . |   .|.  ..|.  ||||.. .    .|||  ||.||| ..
eilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaal

TVAYLMQKLCLSLNDAYDFVKERKSNISPNFNFMGQLKDFEQ
 .||.|.   |   .|. .|.||.  |.||  |. |||..| 
viayimetyglkyreafayvqerrfcinpnegfvsqlkeyea
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 226-324 4.2e-21 68.6 In-house 43-141 (145) alignment 
Range on Protein: 226-324
Range on HMM: 43-141/145.0
EDNGIKYMQIPIMDHWSQNLAAFFPEAIEFIDEARRAKSGILVHCLAGVSRSVTVTVAYLMQKLCLSLNDAYDFVKERKSNISPNFNFMGQLKDFEQKL
  . |. . |   |  | .|.  | |  .|||  .   .|..|||.|||||||||.||.||.   ..| .|   |. ..    || .|. .| ..|..|
ksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkycnmtlseaarqvrsnrllaypnvtflknllnlekql
0051429 (Phosphotyrosine protein) phosphatases II 186-324 5.8e-20 67.5 In-house 17-224 (272) alignment 
Range on Protein: 186-324
Range on HMM: 17-224/272.0
AQILPYLYLGTKQ----DCENFELFSKLRIRYVLNVTPNI-----PNCFEDNGIKYMQIPIMDHWSQNLAAFF---------------------------
 ...| ... . .    ....|. . .|.|........       .  ..  ||.|...||.|.  .    ..                           
rvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsa

---------------------PEAIEFIDEARRaKSGILVHCLAGVSRSVTVTVAYLMQkLCLS--------------LNDAYDFVKERKSNISPNFNFM
                      . .|.... .. .  .|||| ||..|. || ...|.  | .|              | .|.. ....  .. ..  ..
gearevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqy

GQLKDFEQKL
 .| .....|
lflyeallel
subfamily_MSG5_pd Subfamily MSG5 209-326 2.1e-19 63.2 In-house 46-162 (165) alignment 
Range on Protein: 209-326
Range on HMM: 46-162/165.0
LRIRYVLNVTPNIPNC-FEDNGIKYMQIPiMDHWSQnLAAFFPEAIEFIDEARRAKSGILVHCLAGVSRSVTVTVAYLMQKLCLSLNDAYDFVKERKSNI
| .  |.||. .|..  .    .||  |   .| |. ..  ...  . |  |.  .  |||||  |.||| .. |||.|.   |||.|||| .| .  .|
lsfdlvinvakeindlellvpavkyyhie.wehdsk.ivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddi

SPNFNFMGQLKDFEQKLST
||.. .. || ..|  ||.
spsiglifqlmewevalsk
subfamily_PTPMT1_pd Subfamily PTPMT1 213-324 1.1e-18 62.3 In-house 57-168 (171) alignment 
Range on Protein: 213-324
Range on HMM: 57-168/171.0
YVLNVTPNIPNCFEDNGIKYMQIPIMDHWSQNLAAFFPEAIEFIDEARRAKSGILVHCLAGVSRSVTVTVAYLMQKLCLSLNDAYDFVKERKSNISPNFN
| |..  |  . .. .|....|....|.  .   .   ...|||.. .  .. . ||| || .|| |.  .|||.|  ||...| ...|.... |  . .
yelkalansteewkklgveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakk

FMGQLKDFEQKL
 . .|. .|.||
qwkalqeyeekl
0043336 (Phosphotyrosine protein) phosphatases II 209-322 8.5e-18 60.2 In-house 156-274 (278) alignment 
Range on Protein: 209-322
Range on HMM: 156-274/278.0
LRIRYVLNVTP-NIPNCFEDNGIKYMQIPimDHWSQ-NLAAFFPEAIEFIDEARRAKSGILVHCLAGVSRSVTVTVAYLM-----QKLCLSLNDAYDFVK
  ....|.||.   ..... ... |. .|  ||    .|. ..    ....  .  .. .|||| |||.|. |. ..||.       ....| .|.....
dytvrtlevtnlgdgesrtvthyhylgwp..dhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelr

ERKSNISPNFNFMGQLKDFEQ
|.. .. ...... .| ....
eqRpgavqtpsqyrflyeall
0036941 (Phosphotyrosine protein) phosphatases II 186-324 2.3e-17 58.7 In-house 20-276 (297) alignment 
Range on Protein: 186-324
Range on HMM: 20-276/297.0
AQILPYLYLGTKQDCENFELFS----------------------------------------------------------KLRIRYVLNVTPNIPNCF--
 ..||.|.||..   .. |  .                                                          ..... ....|. ... .  
eellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrek

--------------------------------------------EDNGIKYMQIPIMDHWSQNLAAFFPEAIEFIDEARR------AKSGILVHCLAGVS
                                            ...  . ... ...    ..   . . ..||...|.       .. .|||| |||.
caqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvg

RSVTVTVAYLM--------QKLCLSLNDAYDFVKERKSNISPNFNFMGQLKDFEQKL
|| |. .|.||           .... .|. ...|.. .. ...... .| .....|
RsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallel
0047943 (Phosphotyrosine protein) phosphatases II 210-317 4.1e-14 48.1 In-house 150-264 (273) alignment 
Range on Protein: 210-317
Range on HMM: 150-264/273.0
RIRYVLNVTP-NIPNCFEDNGIKYMQIPimDHWSQNLAAFFPEAIEFIDEARR---AKSGILVHCLAGVSRSVTVTVAYLM-----QKLCLSLNDAYDFV
 . ..| .|. . ..... . . |. .|  ||      . . | ||....|..    .. ..||| |||.|. |. ...|.      . .... .|. ..
ytvrtleltnlgtgesrtvthfhytgwp..dhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkll

KERKSNISPNFNFMGQL
.... .. ...... .|
rsqRpgmvqtpeqyrfl
Rhodanese Rhodanese-like domain 26-140 1.3e-12 40.2 Pfam-A 5-112 (113) alignment 
Range on Protein: 26-140
Range on HMM: 5-112/113.0
VQEQVLSGQVLLMDYRPNSAFCRAHIEGALNVCLPGIllrrlQKGNLSLKCLIQGDEGKDLFVKMASKVPLILYDenssNINANSDTPFVL-LLRRLKEV
..|.  ...|.|.| |. ... . ||.||.||.|. .     .. . .       .| ...  |  .. . ..|.    .  ..| . . | |   |||.
lkellekekvvllDvRspeeyakghIpgAvnvpldsl.....yprrdlffkdklaeeleesgkkldkdktvvvyc....rsgnrsggaaalllalilkel

GY-RVSYLRGGFSEFYR
|| .|..|.|||.....
gyknvyvLdGGfeawka
0051299 (Phosphotyrosine protein) phosphatases II 212-312 9.2e-12 40.5 In-house 164-273 (288) alignment 
Range on Protein: 212-312
Range on HMM: 164-273/288.0
RYVLNVTP-----NIPNCFEDNGIKYMQIPimDHWSQNLAAFFPEAIEFIDEARRA-KSGILVHCLAGVSRSVTVTVAYLM-----QKLCLSLNDAYDFV
 ..| ||.        .... . . |...|  ||   . .  . . ......|... .. ..||| |||.|. |. ...|.     .. .... .|. ..
vrtlevtnldlldgdgesrtvthfhytnwp..dhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrl

KERKSNISPNFN
.|.. .. ....
reqRpgmvqtpe
0046845 (Phosphotyrosine protein) phosphatases II 207-309 1.3e-11 39.9 In-house 145-258 (284) alignment 
Range on Protein: 207-309
Range on HMM: 145-258/284.0
SKLRIRYVLNVTPN--IPNCFEDNGIKYMQIPimDHWSQNLAAFFPEAIEFIDEARRA---KSGILVHCLAGVSRSVTVTVAYLMQKL--------CLSL
 .  ....| .|..    . .. . . |...|  ||     .. . | .....|....   .. |.||| |||.|. |. ...|. ..        ....
kddytvrtleltnlgytgesrtvthfhytswp..dhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdv

NDAYDFVKERKSNISP
 .|. ...|.. .   
leavkrlreqRpgmvq
0050432 (Phosphotyrosine protein) phosphatases II 214-311 3.6e-10 35.1 In-house 185-285 (308) alignment 
Range on Protein: 214-311
Range on HMM: 185-285/308.0
VLNVTP-NIPNCFEDNGIKYMQIPimDHWSQNLAAFFPEAIEFIDEARrAKSGILVHCLAGVSRSVTVTVAYLM-----QKLCLSLNDAYDFVKERKSNI
.| .|. . .. .. . . |.  |  ||   . .. . . .|.... .  .. |.||| |||.|. |. ...|.     .. .... .|. ...|.. . 
tleltnlgdgesrtvthfhytnWp..dhgvPpspeilldflelvrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgm

SPNF
 ...
vqtp
subfamily_Laforin_pd Subfamily Laforin 212-325 1.4e-08 27.8 In-house 59-173 (183) alignment 
Range on Protein: 212-325
Range on HMM: 59-173/183.0
RYVLNVTPNIPNCFEDNGIKYMQIPIMDHWSQNLAAFFPEAIEFIDEARRAKSGILVHCLAGVSRSVTVTVAYLMQKLCLSLNDA-YDFVKERKSNISPN
||  |.   . . . ..|. |. .|. |  ...    .|.|. ..         . ||| ||| || .. . .|.  |  ||.   | ..  |      .
rynenlpitlkklykeeglayiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvvyide

FNFMGQLKDFEQKLS
  ..   ||| ||..
ealiraekdfiqkfg
subfamily_RNGTT_pd Subfamily RNGTT 173-307 4.6e-08 27.0 In-house 18-158 (189) alignment 
Range on Protein: 173-307
Range on HMM: 18-158/189.0
LVQAETPLDNRYPAQILPYLYLGTKQDCENFELFsKLRIRYVLNVTPNIP----NCFEDNGIKYMQIPIMDHWSQNLAAFFPEAIEFIDE--ARRAKSGI
..   ||| .||  ..       ..  .. ...  | ....|...| . .    . .|..||||... .  .  .  |    | |. ..|  ...... |
flpfktplskrydddlaeenrfepsmllsylktl.kvklglvidltntsryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkknpeevi

LVHCLAGVSRSVTVTVAYLMQKLCLSLNDAYD-FVKERKSNI
 |||  |  |.  . |.||..| . |...| . | | |.  |
gvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGi
subfamily_DSP23_pd Subfamily DSP23 202-303 4.9e-07 24.5 In-house 23-124 (148) alignment 
Range on Protein: 202-303
Range on HMM: 23-124/148.0
NFELFSKLRIRYVLNVTPNIPNCFE-DNGIKYMQIPIMDHWSQNLAAfFPEAIEFIDEARRAKSGILVHCLAGVSRSVTVTVAYLMQKLCLSLNDAYDFV
... .  | .||.. .| . .   |   .. .... | |.    |     | .. ..||   .  . |||| |  |. |.   ||...  |.  .|   |
qyrylldlgvrylvslteegrphveatpnltlvrlriddyhppaleq.vvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaev

KER
...
rrl
PTPc_DSPc_SM00012 250-299 6.7e-07 24.8 In-house 20-78 (105) alignment 
Range on Protein: 250-299
Range on HMM: 20-78/105.0
PEAIEFIDEARRAKS------GILVHCLAGVSRSVTVTVAYLMQKLCLSL---NDAYDF
 . .|.... .. |.       ..||| |||.|. |....... . . .     | ...
dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqi
0048567 (Phosphotyrosine protein) phosphatases II 244-309 7.9e-07 23.6 In-house 55-123 (157) alignment 
Range on Protein: 244-309
Range on HMM: 55-123/157.0
NLAAFFPEAIEFIDEARRAKSGILVHCLAGV---SRSVTVTVAYLMQKLCLSLNDAYDFVKERKSNISP
 |  |.  . .|..  . |.  | ||| ||    .|..|.  .||. .| .. ..|.....    .. |
ilyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvp
subfamily_PTEN_pd Subfamily PTEN 228-304 1.6e-06 23.2 In-house 78-156 (184) alignment 
Range on Protein: 228-304
Range on HMM: 78-156/184.0
NGIKYMQIPIMDHWSQNLA---AFFPEAIEFIDEARraKSGILVHCLAGVSRSVTVTVAYLMQKLCLSLN-DAYDFVKERK
   . ...|. || . .|    ..  .. ....| .  |  . ||| ||  |. ...||||...| |. . .| .. .| .
fdgrvavypfdDhnppplelleeivediekwleedk..knvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaR
subfamily_PTPDC1_pd Subfamily PTPDC1 223-323 2.2e-06 22.2 In-house 76-174 (182) alignment 
Range on Protein: 223-323
Range on HMM: 76-174/182.0
NCFEDNGIKYMQIPIMDHWSQNLAAFFpEAIEFIDEARRAKsGILVHCLAGVSRSVTVTVAYLMQKLCLSLNDAYDFVKERKSNISPNFNFMGQLKDFEQ
. . ..|| ...... |. .. |   . . .  .. | . .  . ||| ||  |   .  .||. .  |. ..| ..|......     . .  .|.|..
ealmeqgiyvynfgwkDygvasleriL.divkvvafalqeg.kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelvkefal

K
 
f
subfamily_DSP11_pd Subfamily DSP11 174-306 4.9e-06 20.5 In-house 21-159 (178) alignment 
Range on Protein: 174-306
Range on HMM: 21-159/178.0
VQAETPLDNRYPAQILPYLYLGTKQDCENFELfSKLRIRYVLNVTPN----IPNCFEDNGIKYMQIPIMDHW--SQNLAAFFPEAI-EFIDEARRAKSGI
.   |||.... ...     ...|.  |. .   . ..  |...|       .. ..|.|.||... .  |   ...|.  | ||. ||...    .. |
iafktPlkesfdkkveeekrftpkdLleklqe.knkklGLvidltntdryykkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkli

LVHCLAGVSRSVTVTVAYLMQKLCLSLNDAYDFVKERKSN
 |||  || |.  .   ||...  .. .|| .  .| .  
gvhCthGvnrtGyliCrylidvegyepedaieafeearGh
Y_phosphatase Protein-tyrosine phosphatase 250-299 6.1e-06 21.2 Pfam-A 153-208 (235) alignment 
Range on Protein: 250-299
Range on HMM: 153-208/235.0
PEAIEFIDEARRAK----SGILVHCLAGVSRSVTVTVAYLMQKLCLS--LNDAYDF
 . ...|.. .. |    . ..||| |||.|. |. .. .. . . .    | ...
kslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqi
Y_phosphatase Protein-tyrosine phosphatase 250-299 6.1e-06 21.2 In-house 153-208 (235) alignment 
Range on Protein: 250-299
Range on HMM: 153-208/235.0
PEAIEFIDEARRAK----SGILVHCLAGVSRSVTVTVAYLMQKLCLS--LNDAYDF
 . ...|.. .. |    . ..||| |||.|. |. .. .. . . .    | ...
kslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqi
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 251-294 6.9e-06 20.3 In-house 197-241 (307) alignment 
Range on Protein: 251-294
Range on HMM: 197-241/307.0
EAIEFIDEARRAKSGILVHCLAGVSRSVT-VTVAYLMQKLCLSLN
 ||....  |  .  ..||| ||| || | |.......|.    |
tainlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGin