Gene PTPMT1 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily PTPMT1
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP024_AA protein Get Run
SpurP024_AA_24-177 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPMT1_pd Subfamily PTPMT1 8-177 1.1e-79 260.8 In-house 1-171 (171) alignment 
Range on Protein: 8-177
Range on HMM: 1-171/171.0
FYPTLYWNVFMKNVTSRNWYDRIDSTVILGALPFRSYIDQL-KEENVKGVISLNEDHELRRHAPTVEEWKNHGIEHLQLPTVDFTEAPSLEYLERGVEFI
|||||..||.......||||||||.|||||||||||.|..| ..||||.|.||||..||...| ..||||..|.|.|||.||||||||.|| ||.|||||
fyPtllynvlvekaskrnwydriDdtvilGalPfrslikeLiekenvkavvslneeyelkalansteewkklgveqlqlatvDfteapdleklekgvefi

QQHANDGSSVYVHCKAGRTRSATLVGCYLMMMNHCTPQEAQTFMEAKRPHILLKDRHFRALYRYYDKHVKK
...|..|..|||||||||.||||||.||||......|.||......||..|.|......||..|..|...|
ekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeekllsk
0044763 (Phosphotyrosine protein) phosphatases II 9-175 1.8e-38 127.3 In-house 5-171 (178) alignment 
Range on Protein: 9-175
Range on HMM: 5-171/178.0
YPTLYWNVFMKNVTSRNWYDRIDSTVILGALPFRSYIDQLKEENVKGVISLNEDHELRRHAPTVEEWKNHGIEHLQLPTVDFTEAPSLEYLERGVEFIQQ
.. | .|. . . .  .....|.  ..||.||  .....|||.... ...|.|. || ..    . ....||..|..|..|... ..||.... ||||..
trvllsnleglersdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefiee

HA-NDGSSVYVHCKAGRTRSATLVGCYLMMMNHCTPQEAQTFMEAKRPhILLKDRHFRALYRYYDKHV
.  ..|. |.|||.||. ||.||| .|||........||  .. ..|| |   . . | ||... .. 
aldekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrll
0046846 (Phosphotyrosine protein) phosphatases II 19-176 3.1e-37 123.4 In-house 4-174 (176) alignment 
Range on Protein: 19-176
Range on HMM: 4-174/176.0
KNVTSRNWYDRIDSTVILGALP----------FRSYIDQLKEENVKGVISLNEDHELRRH--APTVEEWKNHGIEHLQLPTVDFTEAPSlEYLERGVEFI
.  . ....|.|.  .|||..|          . .....|||.... |..|.|..|| |.  .   .|....||..|.||..|..  .. |.|.. .|||
rllgldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefi

QQHANDGSSVYVHCKAGRTRSATLVGCYLMMM-NHCTPQEAQTFMEAKRP-HILLKDRHFRALYRYYDKHVK
... ..|  |.|||.||. |..||| .||..  .. ...||  .. ..|| ...  . . | ||... .. |
realkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefellllk
PTEN_1 14-174 3.2e-33 110.2 In-house 20-191 (196) alignment 
Range on Protein: 14-174
Range on HMM: 20-191/196.0
WNVFMKN--------VTSRNWYDRIDSTVILGALPFR-SYIDQLKEENVKGVISLNEDHELrrH--APTVEEWKNHGIEHLQLPTVDFTEAPSLEYLERG
..... .          ||. ...|| ....| |..  .. |.|||... .|..|.|. ||  .    . ||....|.|.|..|  |..  .  | ..  
ldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeel..sgrsydleeffksgveylhfpieDhgapslselfdic

VEFIQQHA--NDGSSVYVHCKAGRTRSATLVGCYLMMMNHCTPQEAQTFMEAKRPHILLKDRHFRALYRYYDKH
..||..    ..|  |.||||||..||.|.| .|||  .  |..||  .. .|||.. .  .. ..| .|... 
ksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfael
0038934 (Phosphotyrosine protein) phosphatases II 24-182 1e-32 108.7 In-house 29-184 (194) alignment 
Range on Protein: 24-182
Range on HMM: 29-184/194.0
RNWYDRIDSTVILGALPFRSYIDQLKEeNVKGVISLNEDhelrRHAPTVEEWKNHGIEHLQLPTVDFTEAPSLEYLERGVEFIQQHAN--DGSSVYVHCK
 .....|.... ..   . .|...|.. ..  ||.|...     .   .||....|||.|.||..|. ..|||| | | ....... |   |  |.||||
gsldkyieelyrfspedlvrylkllnv.klglvidltnt....eryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCk

AGRTRSATLVGCYLMMMNHCTPQEAQTFMEAKRPHILLKDRHFRALYRYYDKHVKKARPNK
||. |..|||..||.........||  ... |||... .   ..||...|.   |......
aGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykelrkavlape
0048076 (Phosphotyrosine protein) phosphatases II 25-173 3.3e-32 106.5 In-house 2-141 (145) alignment 
Range on Protein: 25-173
Range on HMM: 2-141/145.0
NWYDRIDSTVILGALPFRSYIDQLKEENVKGVISLnedhelrrhAPTVEEWKNHGIEHLQLPTVDFTEAPSLEYLERGVEFIQQHANDGSSVYVHCKAGR
.|...|.  . || ||  . ...||. ... |..|         ... | ....||..|.||. |... ..||.|.. .|||... ..|  |.|||.||.
ywpseilpglylgslptaldlellkdlgittvlnl.........tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGv

TRSATLVGCYLMMMNHCTPQEAQTFMEAKRPHILLKDRHFRALYRYYDK
 |..|||..|||........||  .. ..||..   . ..| ||... .
gRtgtlvaaylmlllgvsleealelvrsqrpgavpnpgqlrflyefele
0048179 (Phosphotyrosine protein) phosphatases II 25-172 5.8e-32 105.7 In-house 2-142 (144) alignment 
Range on Protein: 25-172
Range on HMM: 2-142/144.0
NWYDRIDSTVILGALPFRSYIDQLKEENVKGVISLNEDHelrrhapTVEEWKNHGIEHLQLPTVDFTEAPSLEYLERGVEFIQQHANDGSSVYVHCKAGR
.....|.. . || ||. . ...||. ... ||.|.|..         |.....||..|.||. |.   ..||.|.. .|||... ..|  |.|||.||.
snpseilpglylgslptaldlellkklgittvinlteey.......epefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGv

TRSATLVGCYLMMMNHCTPQEAQTFMEAKRPHILLKDRHFRALYRYYD
 |..||| .|||........||  .. ..||..   . ..| |..|..
gRtgtlvaaylmkklglsleealalvrsrrpgavpnpgqlrfLleyek
0036282 (Phosphotyrosine protein) phosphatases II 29-170 1.6e-30 101.5 In-house 14-165 (174) alignment 
Range on Protein: 29-170
Range on HMM: 14-165/174.0
RIDSTVILGALPFRsYIDQLKEENVKGVISLNEDHELRRHAP------TVEEWKNHGIEHLQLPTVDFTEAPSLEyLERGVEFIQQHAND--GSSVYVHC
.| . .|.|. |.. ....|||.... |..|.| .|| ..        . | ....||..|.||..|... .. . |.. |.|.... ..  |  |.|||
yitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHC

KAGRTRSATLVGCYLMMMNHC-TPQEAQTFMEAKR---PHILLKDRHFRALYRY
.||. |..|||..|||..... ....|  .. ..|   |..   . ..| || .
saGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyf
0051082 (Phosphotyrosine protein) phosphatases II 26-171 3.5e-30 100.0 In-house 7-149 (151) alignment 
Range on Protein: 26-171
Range on HMM: 7-149/151.0
WYDRIDSTVILGALPFRSYIDQLKEENVKGVISLNEDHELRrhaPTVEEWKNHGIEHLQLPTVDFTEAPSLEYLERGVEFIQQHAND-GSSVYVHCKAGR
.. .... ..... |   ....|||...| ...|....|        | ....|||.|..| .|... .  ....  .||... ... .  |.|||.||.
nfsyvtgglyrsggpladflellkelgiktivnlrseeerg...ycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGk

TRSATLVGCYLMMmNHCTPQEAQTFMEAKRPHILLKDRHFRALYRYY
 |..|||..|||.  .....||  .. .|||..     .|. .....
gRTGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfal
0041856 (Phosphotyrosine protein) phosphatases II 17-169 1.5e-29 98.3 In-house 11-165 (182) alignment 
Range on Protein: 17-169
Range on HMM: 11-165/182.0
FMKNVTSrnWYDRIDSTVILGALPF--------------RSYIDQLKEENVKGVISLNedhelrRHAPTVEEWKNHGIEHLQLPTVDFTEAPsleyLERG
.. . .   ..|.|   ..||.||.               .....|||.... ...|.       .    |.....||..|.||  |..  .    |.  
lpydhsr..dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt......eelywpellerlgiqylylpwpDhgvpd....ldel

VEFIQQHANDGSSVYVHCKAGRTRSATLVGCYLMMMNHCTPQEAQTFMEAKRPHILLKDRHFRALYR
..||..  ..|  |.|||.||. |..|||..|||. ......||  ..  .||..     ... |..
ldfieevleeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflql
0045098 (Phosphotyrosine protein) phosphatases II 7-176 3e-29 97.7 In-house 19-273 (278) alignment 
Range on Protein: 7-176
Range on HMM: 19-273/278.0
LFYPTLYWNVFMKNVTSRNWYDRI--------------------DSTVILGALP----FRSYIDQLKEENVKGVISLNEDHELRRHA-------------
|..|  ...  . .  ..|.|  |                    . . |. . |    . .....|.|.... ...|.| .|| |               
lgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggslty

---------------------------PTVEEWKNHGIEHLQLPTVDFTEAPSLE---YLERGVEFIQQHAN--------------DGSSVYVHCKAGRT
                              |.....|..||......  ..|||.   .. . .|||... .              .|  |.|||.||  
gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvg

RSATLVGCYLMMMN---HCTPQEAQTFMEAKRPH-ILLKDRHFRALYRYYDKHVK
|..|||..|||. .   .....|| ...  .||. ..    ..| ||..  ....
RtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllelll
0043147 (Phosphotyrosine protein) phosphatases II 25-172 3.9e-29 97.0 In-house 17-158 (172) alignment 
Range on Protein: 25-172
Range on HMM: 17-158/172.0
NWYDRIDSTVILGALPFRSYIDQLKEENVKGVISLNEDhelrrhAPTVEEWKNHGIEHLQLPTVDFTEApSLEYLERGVEFIQQ--HANDGSSVYVHCKA
 . ||.  |  ..  .. .....|||.... ...|.|         . |  . .||..| ||  |..   .||.|.. .|||..  . ..|  |.|||.|
yipdrfiatqgplrntladfwrmlkelgithivnltel......lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsa

GRTRSATLVGCYLMMmNHCTPQEAQTFMEAKRPHILLKDRHFRALYRYYD
|  |..||| .|||.  .....||  .. .|||..   . . | || . .
GvgRtgtlvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfek
0049772 (Phosphotyrosine protein) phosphatases II 25-174 1.7e-28 95.7 In-house 114-273 (314) alignment 
Range on Protein: 25-174
Range on HMM: 114-273/314.0
NWYDRIDSTVILG-----------------------------ALPFRSYIDQLKeenvkgvislnedhelrRHAPTVEEWKNHGIEHLQLPTVDfTEAPS
 ... ... .| .                             ..|  .....||                 .     | ....||..|..|. |  .||.
vlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgngneptaadlellk.................eelydpelferlgikylripvpD.gsapl

LEYLERGVEFIQQHaNDGSSVYVHCKAGRTRSAT-LVGCYLMMMNHCTPQEAQTFMEAKRPhILLKDRHFRALYRYYDKH
||.... .|||... ..|. |.||||||. |..| .| .|||. ......||  .. .||| |  ... .. | .|. ..
ledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefil
0049260 (Phosphotyrosine protein) phosphatases II 30-172 1.2e-27 91.9 In-house 11-147 (152) alignment 
Range on Protein: 30-172
Range on HMM: 11-147/152.0
IDSTVILGALPFRSYIDQLKEENVKGVISLNEDHElrrhapTVEEWKNHGIEHLQLPTVDFTEAPSLEYLERGVEFIQQ-HANDGSSVYVHCKAGRTRSA
.  |  .|  .. .....||| ... ...|.|..|        ... ...|..|.||. |..  .. ..|.  ..||..   ..|  |.|||.||  |..
fiatqgpgpntladfwrmlkelgittivmltelle......lgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtg

TLVGCYLMMmNHCTPQEAQTFMEAKRPHILLKDRHFRALYRYYD
||| .|||. ......||  .. .|||..     . | || ...
tlvaaylml.lgvsleeavalvrekRpgavpnpgqlrflyefek
PTPc_motif_SM00404 29-173 3.2e-27 90.1 In-house 4-140 (140) alignment 
Range on Protein: 29-173
Range on HMM: 4-140/140.0
RIDSTVILGALPFRSYIDQLKEENVKGVISLNEDHELRrhaptveeWKNHGIEHLQLPTVDFTEAPSLEYLERGVEFIQQHANDGSSVYVHCKAGRTRSA
||   ..|| ..  .  ..||. ... ||.. |  .|.         .| |...||.|  | .... ..||.. ..||.. ...| .|.|||.|| .|||
rilphlylgskskaqnpallkklgithvinvteevslt........kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSa

TLVGCYLMMMNHCTPQEAQTFMEAKRPHILLKDRHFRALYRYYDK
||. .|||. .... .||  |.. .||.|  . ...| |. |..|
tliiaYlmryrqlslaeayefvkerRpiispnlnfvrqLieyekk
DSPc Dual specificity phosphatase, catalytic domain 36-172 3.7e-27 89.8 Pfam-A 3-132 (133) alignment 
Range on Protein: 36-172
Range on HMM: 3-132/133.0
LGALPFRSyIDQLKEENVKGVISLNEDHELRrhaptvEEWKNHGIEHLQLPTVDFTEAPSLEYLERGVEFIQQHANDGSSVYVHCKAGRTRSATLVGCYL
||. .  |  ..|.. ... ||.. .  . .       . |.  ||.|..|  |.||.   ..||. ||||.. ...| .|.|||.|| .|||||. .||
lgskstas.lalleklgitlvinvtkevpnn......naikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYl

MMMNHCTPQEAQTFMEAKRPHILLKDRHFRALYRYYD
|. .... .||  |.. .|..|  .... | |. |..
mktknlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 36-172 3.7e-27 89.8 In-house 3-132 (133) alignment 
Range on Protein: 36-172
Range on HMM: 3-132/133.0
LGALPFRSyIDQLKEENVKGVISLNEDHELRrhaptvEEWKNHGIEHLQLPTVDFTEAPSLEYLERGVEFIQQHANDGSSVYVHCKAGRTRSATLVGCYL
||. .  |  ..|.. ... ||.. .  . .       . |.  ||.|..|  |.||.   ..||. ||||.. ...| .|.|||.|| .|||||. .||
lgskstas.lalleklgitlvinvtkevpnn......naikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYl

MMMNHCTPQEAQTFMEAKRPHILLKDRHFRALYRYYD
|. .... .||  |.. .|..|  .... | |. |..
mktknlslneAyefvkerrskispnagflrqLleyer
0042113 (Phosphotyrosine protein) phosphatases II 24-171 1.1e-26 89.2 In-house 12-239 (245) alignment 
Range on Protein: 24-171
Range on HMM: 12-239/245.0
RNWY--------------------------------DRIDSTVILGALPFRSYID----QLKEENVKGVISLNEDHELRRH-------------------
.|.|                                .||  ..|... | .. ..    .|.|.... ...|.|..|| |.                   
knrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftv

------------------APTVEEWKNHGIEHLQLPTVDFTEAPSLEYLERGVEFIQQHAN--DGSSVYVHCKAGRTRSATLVGCYLM-----MMNHCTP
                   .. . .. ..| ...||  |......||.|.. .||.... .  ..  |.|||.||. |..|....|||          ..
tllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsl

QEAQTFMEAKRPHILLKDRHFRALYRYY
.||  ..  .||..   . ..| ||.. 
eeavkelrsqRpgavqtpsqyrflyeal
0037934 (Phosphotyrosine protein) phosphatases II 27-172 2.8e-26 88.0 In-house 39-239 (243) alignment 
Range on Protein: 27-172
Range on HMM: 39-239/243.0
YDRIDSTVILGALPFRS--------YIDQLKEENVKGVISLNEDHELRRHA------------------------------------PTVEEWKNHGIEH
. ..  ..|.. .|  .        ... |.|.... ...|.|. || |                                      .  .... ..| .
liyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihy

LQLPTVDF----TEAPSLEYLERGVEFIQQ-----HANDGSSVYVHCKAGRTRSATLVGCYLMMMN-HCTPQEAQTFMEAKRPH-ILLKDRHFRALYRYY
..||  |.    . .. |..|.   |||..     ....|. |.|||.||. |..||. .|||... .....||  .. ..||. .     ..| ||...
hylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeal

D
 
l
0039614 (Phosphotyrosine protein) phosphatases II 26-177 1.1e-22 76.4 In-house 61-291 (297) alignment 
Range on Protein: 26-177
Range on HMM: 61-291/297.0
WY----------------------------------DRIDSTVILGALPFRSY----IDQLKEENVKGVISLNEDHELRRHA----------------PT
.|                                  |... ..|.   |  .     .  ..|..|. ...|..  || |.                  .
rykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtl

VEEWKNHGIEHLQLPT-----------------VDFTEAPSLEYLERGVEFIQQHAN---DGSSVYVHCKAGRTRSATLVGCYLM-----MMNHCTPQEA
... ...|. . .|.                   |..  ||||.| . .|..... .   .|  |.|||.||  |..|....|||        . ...||
lkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvlea

QTFMEAKRPHILLKDRHFRALYRYYDKHVKK
  ..  .||..   . ..| ||..  ...|.
vkelreqRpgavqtpsqyrflydallellkr
0040438 (Phosphotyrosine protein) phosphatases II 31-176 1.4e-21 72.6 In-house 85-277 (317) alignment 
Range on Protein: 31-176
Range on HMM: 85-277/317.0
DSTVILGALPFRS----YIDQLKEENVKGVISLNEDHELRR------------------HAPTVEEWKNHGIEHLQLPT-------------------VD
  . |.   |  .    ..  ..|..|. ...|.|  || |                  .  ...| ...||....|.                     |
krkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpd

FTEAPSLEYLERGVEFIQQHAND-GSSVYVHCKAGRTRSATLVGCYLM-----MMNHCTPQEAQTFMEAKRPHILLKDRHFRALYRYYDKHVK
..  ||.. | . .|..... .| |. | |||.||  |..|....|||       ......||  .. ..||..     ..| ||..  ...|
hgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylk
0045450 (Phosphotyrosine protein) phosphatases II 38-172 2.3e-21 72.3 In-house 113-301 (307) alignment 
Range on Protein: 38-172
Range on HMM: 113-301/307.0
ALPFRSY----IDQLKEENVKGVISLNEDHELRRH-------------------APTVEE-----------------WKNHGIEHLQLPTV---DFTEAP
  |  .     . .|.|..|. ...|.|. || |                      ...|                  .. .... ...     |..  |
qgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpp

SLEYLERGVEFIQQHAN---DGSSVYVHCKAGRTRSATLVGCYLMMMNH--------CTPQEAQTFMEAKRPHILLKDRHFRALYRYYD
|.| | . .| .... .   .|. |.|||.||  |..|....|||. ..        ....||  .. ..||..     ..| ||..  
sfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeall
0051429 (Phosphotyrosine protein) phosphatases II 34-173 3.5e-21 71.5 In-house 24-223 (272) alignment 
Range on Protein: 34-173
Range on HMM: 24-223/272.0
VILGALP---FRSYIDQLKEENVKGVISLNEDHELRRhAPTVEEWknHGIEHLQLPTVDFTEAPSLEYL-------------------------------
..... |       ...|||...| ...| ...|. |  ..  .|  .||..|.||..|... . | .                                
lyrsggplpltaadfwrlkelgiktivdLrseeErgr.lkcdryw..pgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagear

-----------------ERGVEFIQQHANdGSSVYVHCKAGRTRSATLVGCYLMMmNHCT--------------PQEAQTFMEAKRPHILLKDRHFRALY
                 |  .|.... .. |  |.|||.||. |..|.| ..|..    .              ..||   . |.||..   . ... ||
evmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylfly

RYYDK
... .
ealle
0040439 (Phosphotyrosine protein) phosphatases II 33-172 4.2e-21 71.1 In-house 55-243 (249) alignment 
Range on Protein: 33-172
Range on HMM: 55-243/249.0
TVILGALPF----RSYIDQLKEENVKGVISLNEDHELRRHA---------------------------------------PTVEEWKNHGIEHLQLPtvD
..|.   |      .....|.|.... ...|... || |                                          . |. . ..| .. .|  |
rfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp..d

FTEAPSLEYLERGVEFIQQHAN---DGSSVYVHCKAGRTRSATLVGCYLM-----MMNHCTPQEAQTFMEAKRPHILLKDRHFRALYRYYD
.   ||.| | . .| .... .   .|. |.|||.||  |..|....|||       .. ...||  ..  .||..   . ..| ||..  
hgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeall
subfamily_DSP12_pd Subfamily DSP12 28-178 1.1e-20 68.6 In-house 3-147 (155) alignment 
Range on Protein: 28-178
Range on HMM: 3-147/155.0
DRIDSTVILGALPFRSYIDQLKEENVKGVISLNEDHElrrhapTVEEWKNHGIEHLQLPTVDFTEAPSLEYLERGVEFIQQHANDGSSVYVHCKAGRTRS
.||.  . || |.   . ..||| ... |.|. . .         .. |.  ....... .|  |.. |..|.. |.||..  ... .|.|||.||  ||
srilpglylggleavqeeellkelkithvlsvikeel......pehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRS

ATLVGCYLMMMNHCTPQEAQTFMEAKRPHILLKDRHFRALYRYYDKHVKKA
.|.|  |||  ...  ..|  ....|.|.|   .   . |  ..   .|  
vtiviAYlmkkeklslekAlklvkekkpeiepNegFleQLklfekmgckvd
0043336 (Phosphotyrosine protein) phosphatases II 31-171 1e-19 66.6 In-house 87-273 (278) alignment 
Range on Protein: 31-171
Range on HMM: 87-273/278.0
DSTVILGALPFRSY----IDQLKEENVKGVISLNEDHELRRHA--------------------------------------PTVEEWKNHGIEHLQLPtv
  ..|.   |  .     .  ..|..|. ...|.|. || |                                         . |. . ... .|  |  
prkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp..

DFTEAPSLEYLERGVEFIQQHAN-DGSSVYVHCKAGRTRSATLVGCYLM-----MMNHCTPQEAQTFMEAKRPHILLKDRHFRALYRYY
|..  .||. | . ....... . ... |.|||.||  |..|....||.        . ...||  ..  .||...  . ..| ||.. 
dhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeal
0047943 (Phosphotyrosine protein) phosphatases II 43-170 6e-18 60.7 In-house 92-267 (273) alignment 
Range on Protein: 43-170
Range on HMM: 92-267/273.0
SYIDQLKEENVKGVISLNEDHELRR------HAPTVEE-W--------------------------------KNHGIEHLQLPTV-DFTEAPSLEYLERG
.... ..|.||. ...|.|..|| |        ....| .                                . . . |.. ..  |.   ||||.| . 
dfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllef

VEFIQQHAN---DGSSVYVHCKAGRTRSATLVGCYLM-----MMNHCTPQEAQTFMEAKRPHILLKDRHFRALYRY
.|..... .   ... |.|||.||  |..|.. ..|.     . .  .. ||  ..  .||..     ..| ||..
ielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyea
0048567 (Phosphotyrosine protein) phosphatases II 55-170 1.9e-17 58.0 In-house 3-134 (157) alignment 
Range on Protein: 55-170
Range on HMM: 3-134/157.0
GVISLNEDHELRRHAPTVEEWKNHGIEHLQLPT----------VDF---TEAPSLEYLERGVEFIQQHANDGSSVYVHCKAGR---TRSATLVGCYLMMM
 ...|.|. . |  . .. .....  . |.. .           ||   . |   ..  .  .|...  . |  ..||||||.   .|.|||.||||.. 
engdlieiipdrlyfallprlpkslynalyFsiddglvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilh

NHCTPQEAQTFMEAKRPHILLKDRHFRALYRY
.. ||.||  ..   ||....   .  .|. |
lgftpeeaiaplrivrpgsvpfrdasyllsly
0036941 (Phosphotyrosine protein) phosphatases II 44-177 3.4e-17 58.1 In-house 70-279 (297) alignment 
Range on Protein: 44-177
Range on HMM: 70-279/297.0
YIDQL------------------------KEENVKGVISLNEDHELRR-----HAPTV-----------------------------------EEWKNHG
|.|                           |.||. ...|.|. || |       |.                                    .. . . 
yvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrt

IEHLQLPTVDFTEAPS-LEYLERGVEFIQQHAN---DGSSVYVHCKAGRTRSATLVGCYLM--------MMNHCTPQEAQTFMEAKRPHILLKDRHFRAL
. |.. .. .   .|.  ..| . .|..... .   .|. |.|||.||  ||.|.....||        . . ... ||  ..  .||..     ..| |
vthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrfl

YRYYDKHVKK
|..  ...||
yeallellkk
0050432 (Phosphotyrosine protein) phosphatases II 43-176 4.7e-17 57.7 In-house 123-300 (308) alignment 
Range on Protein: 43-176
Range on HMM: 123-300/308.0
SYIDQLKEENVKGVISLNEDHELRRH------APTV---------------------------------EEWKNHGIEHLQLPTV-DFTEAPSLEYLERG
...  . |.||. .. |.. .|  |        ...                                 .. . . . |.. ..  |.   ||.| | . 
dFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldf

VEFIQQHAnDGSSVYVHCKAGRTRSATLVGCYLM-----MMNHCTPQEAQTFMEAKRPHILLKDRHFRALYRYYDKHVK
.|.....  .|. ..|||.||  |..|.. ..|.     . ......||  ..  .||.      ... |||.  ...|
lelvrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylk
subfamily_DSP14_pd Subfamily DSP14 72-177 9.3e-17 55.4 In-house 42-147 (157) alignment 
Range on Protein: 72-177
Range on HMM: 42-147/157.0
VEEWKNHGIEHLQLPTVDFTEAPSLEYLERGVEFIQQHANDGSSVYVHCKAGRTRSATLVGCYLMMMNHCTPQEAQTFMEAKRPHILLKDRHFRALYRYY
. . | ..||....|  | .||   ..... .. |..  ..|  . |||.||. |||.|.  |||  .. . .|| . ....|| |      .. | .| 
lpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylmkyeklsLreayklvksaRpiirPNvGFwkqlidyE

DKHVKK
 |  .|
kklkgk
subfamily_Laforin_pd Subfamily Laforin 26-164 9.5e-17 54.5 In-house 10-161 (183) alignment 
Range on Protein: 26-164
Range on HMM: 10-161/183.0
WYDRIDSTVILGALP-FRSYIDQLKEENVKGVISLNEDHELRRHAPTVEE------------WKNHGIEHLQLPTVDFTEAPSLEYLERGVEFIQQHAND
 | .|   . ||. |  .... .||.| .  ||||. .... ...  ..             .|. |. .. ||| |..    .| | ..| ...   ..
hyskileniwlgscprlvehvidlksegitavislqtesdivknssgiyrynenlpitlkklykeeglayiwlptedlstesrvenlpqavyllhallek

GSSVYVHCKAGRTRSATLVGCYLMMMNHCTPQEAQTFMEAKRPHILLKDRHF
|  |||||.||  ||...|  .|. . . . .  | |. |||| . . .. .
ghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvvyideeal
subfamily_DSP1_pd Subfamily DSP1 31-175 2.4e-16 54.2 In-house 22-156 (163) alignment 
Range on Protein: 31-175
Range on HMM: 22-156/163.0
DSTVILGALPFRSYIDQLKEENVKGVIslNEDHELRRHAPTveewknhGIEHLQLPTVDFTEAPSLEYLERGVEFIQQHANDGSSVYVHCKAGRTRSATL
   . ||.    |  ..||....  ..  |  .||  . ..         |. .|.  | ..|   ...|. .|||..  . .  |..||.||  ||.||
ldfLylGsetvasnleiLkslgitail..nvskeldnvfed.......lfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstl

VGCYLMMMNHCTPQEAQTFMEAKRPHILLKDRHFRALYrYYDKHV
.  |||. .... .|| .|.  .|. |       . |   |.|..
claylmktkrvsleeafdfvkqrRsiisPnagFvlqLl.nyekkl
subfamily_DSP19_pd Subfamily DSP19 78-170 2.8e-16 54.2 In-house 54-146 (152) alignment 
Range on Protein: 78-170
Range on HMM: 54-146/152.0
HGIEHLQLPTVDFTEAPSLEYLERGVEFIQQHANDGSSVYVHCKAGRTRSATLVGCYLMMMNHCTPQEAQTFMEAKRPHILLKDRHFRALYRY
. .. |... .|  |.  |.||.. ..||..  .    |.|||.||. |||..|  |||  .. . .|| . . ..|| |   .  .. | .|
kdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylmkkeelsleealelvrearpcikPneGFikqLkey
subfamily_DSP10_pd Subfamily DSP10 74-157 4e-16 53.3 In-house 53-136 (159) alignment 
Range on Protein: 74-157
Range on HMM: 53-136/159.0
EWKNHGIEHLQLPTVDFTEAPSLEYLERGVEFIQQHANDGSSVYVHCKAGRTRSATLVGCYLMMMNHCTPQEAQTFMEAKRPHI
|........ ..|  | ..    .| |  .|||..  . ||.| |||.||  ||||.|  |||   . . ..|  |.. ||| |
efeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvviaYlmkhlnlslndaykfvkekrpii
subfamily_CDC14_pd Subfamily CDC14 42-159 2.5e-15 51.2 In-house 202-309 (328) alignment 
Range on Protein: 42-159
Range on HMM: 202-309/328.0
RSYIDQLKEENVKGVISLNEDhelrrhAPTVEEWKNHGIEHLQLPTVDFTeAPSLEYLERGVEFIQQHandGSSVYVHCKAGRTRSATLVGCYLMMMNHC
 ....  ...||. |. ||..          ......|..|  |  .| .  || . ... .| ...      .. ||||||  |  ||..||||   . 
eklleyfrknnvttvvrLnkk......lYdakkftdaGfdhkDlffiDGs.tPsdaivkkfleiaeka...eGaiavhCkaGLGrtGtLiacylmkhyrf

TPQEAQTFMEAKRPHILL
| .|| ...   ||  ..
taaeaiawlricrPGsvi
subfamily_DSP3_pd Subfamily DSP3 69-155 3.1e-15 50.2 In-house 52-139 (162) alignment 
Range on Protein: 69-155
Range on HMM: 52-139/162.0
APTVEEWKNHGIEHLQLPTVDFTEAPSLEYLERGVEFIQQHAND-GSSVYVHCKAGRTRSATLVGCYLMMMNHCTPQEAQTFMEAKRP
    | .|. .|..| |.  |. |.   .| |. ..||..  ..  . |.|||..|  ||||||  |||.... | .|| . ...|| 
dtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkRe
0046845 (Phosphotyrosine protein) phosphatases II 44-174 4.9e-15 51.1 In-house 93-273 (284) alignment 
Range on Protein: 44-174
Range on HMM: 93-273/284.0
YIDQLKEENVKGVISLNEDHELRRH-----APTVE---------------------------------EWKNHGIEHLQL---PtvDFTEAPSLEYLERG
.   . |.||. ...|.| .|  |       |. .                                 . . . . |..    |  |.   ||.| | . 
FwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswp..dhgvppspedllef

VEFIQQHAND---GSSVYVHCKAGRTRSATLVGCYLMMMN--------HCTPQEAQTFMEAKRPHILLKDRHFRALYRYYDKH
....... ..   |. . |||.||  |..|.. ..|..          .....||  ..  .||.      ..| .|..   .
lrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealley
0051299 (Phosphotyrosine protein) phosphatases II 43-170 6.9e-15 50.7 In-house 107-281 (288) alignment 
Range on Protein: 43-170
Range on HMM: 107-281/288.0
SYIDQLKEENVKGVISLNEDHELRRHA-------------------------------------------PTVEEWKNHGIEHLQLPtvDFTEAPSLEYL
..   . |.||. ...|.. .|| |                                             .. |. . . . ... |  |.   .|.| |
dFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwp..dhgvpdspell

ERGVEFIQQH-ANDGSSVYVHCKAGRTRSATLVGCYLM-----MMNHCTPQEAQTFMEAKRPHILLKDRHFRALYRY
 . ....... |..|. |.|||.||  |..|.. ..|.       ..... ||  ..  .||..     ..| .|..
ldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyea
subfamily_DSP8_pd Subfamily DSP8 39-173 8.8e-15 48.6 In-house 22-152 (159) alignment 
Range on Protein: 39-173
Range on HMM: 22-152/159.0
LPFRSYIDQLKEENVKGvISLNEDHELRRHAPTVEEWKNHGieHLQLPTVDFTEAPSLEYLERGVEFIQQHANDGSSVYVHCKAGRTRSATLVGCYLMMM
| . |  | |.|| ..  . ..    . .. |..|| |.     |..|  |  .   |..... ||||..  .  ..| ||. ||. ||||.. .|.| .
lylGsqkdvlseellsk.lgisyvlnasnscpkleelkesk..flrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaiayimkt

NHCTPQEAQTFMEAKRPHIlLKDRHFRALYRYYDK
 . . .|| .|.  ||| |  ..  |      |.|
lemsldeayrfvkekrpti.spnlnflgqLleyek
subfamily_DSP15_pd Subfamily DSP15 43-156 1.1e-14 48.8 In-house 18-121 (151) alignment 
Range on Protein: 43-156
Range on HMM: 18-121/151.0
SYIDQLKEENVKGVISLNEdhelrrhaptVEEWKNHGIEHLQLPTVDFTEAPSLEYLERGVEFIQQHANDGSSVYVHCKAGRTRSATLVGCYLMMMNHCT
.  ..|||.|.  ..|...           ..   . ||.. ..  | ..|   ....  |||| .    . .|.||| ||  ||.|||  ||| . .  
kdeelLkeknithilsvhd..........nakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmtvteln

PQEAQTFMEAKRPH
 ..| ....|.|  
wrdalevikaaRsv
subfamily_DSP6_pd Subfamily DSP6 32-157 1.3e-14 48.0 In-house 19-137 (158) alignment 
Range on Protein: 32-157
Range on HMM: 19-137/158.0
STVILGALPFRSYIDQLKEENVKGVISLNEDheLrrhaPT-VEewKNHGIEHLQLPTVDFTEAPSLEYLERGVEFIQQHANDGSSVYVHCKAGRTRSATL
... ||.    | .. ||. ..| |. . ..  |    |   |  ... ...||.|  |  ..   ...   .|||..  .. |.| ||| || .|| |.
pllylGsakdasnlevlkklkikyvlnvtsn..l....pnkfe..esgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtv

VGCYLMMMNHCTPQEAQTFMEAKRPHI
. .|||  .... ..|  ........|
tlaylmkklalslndaydlvkkrksni
subfamily_Slingshot_pd Subfamily Slingshot 29-170 7.9e-14 45.4 In-house 21-153 (169) alignment 
Range on Protein: 29-170
Range on HMM: 21-153/169.0
RIDSTVILGALPFRSYIDQLKEENVKGVISLNEdhElrrhaptVEEWKNHGIEHLQLPTVDFTEAPSLEYLERGVEFIQQHANDGSSVYVHCKAGRTRSA
.|   | ||.    | ...|||..|. .. . .  |       .... .. .|.|..   |  |.  |.| ..  .||..  ..||.| |||| | .|||
kifdhvylGsewnasnleelkengveyilnvtk..e.......idnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsa

TLVGCYLMMMNHCTPQEAQTFMEAKRPHILLKDRHFRALYRY
. |  | |   ... .|| .... .|  |   .  .. |  |
stviayamkeyglsleealeyvkerrsvikPnkgflkqleey
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 31-170 9.6e-14 45.1 In-house 12-143 (148) alignment 
Range on Protein: 31-170
Range on HMM: 12-143/148.0
DSTVILGALPFRSYIDQLKEENVKGVISLNEDHELRRHAPtveewknhGIEHLQLPTVDFTEAPSLEYLERGVEFIQQHANDGSSVYVHCKAGRTRSATL
|. . ||. .. . ...||. .|  ... .....              |||.|...  |  .     . |  ..|.... ..|  | ||.. |. ||. |
dafLFlGskksaadlealkalgvtrivnatkerdnaldqr........gieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssal

VGCYLMMMNHCTPQEAQTFMEAKRPHILLKDRHFRALYRY
.  .|. ... . .||  ... ||...  .  . . |. .
allwlidfkrvslkealalvkskrryvdpnlgfLkqLael
subfamily_PTPDC1_pd Subfamily PTPDC1 45-162 1.7e-13 45.4 In-house 39-163 (182) alignment 
Range on Protein: 45-162
Range on HMM: 39-163/182.0
IDQLKEENVKGVISLNEDHELRR---------HAPTVEEWKNHGIEHLQLPTVDFTeAPSLEYLERGVEFIQQHANDGsSVYVHCKAGRTRSATLVGCYL
.|..||. .| || |.|. |             .   |.....|| . ...  |.  ..||| .   |  ...  ..|  | ||| ||. |   |. |||
ldkfkesgikavinLqekgehasCGagleesGfsYdlealmeqgiyvynfgwkDyg.vasleriLdivkvvafalqeg.kvavhChaGlGrtGvliacyl

MMMNHCTPQEAQTFMEAKRPHILLKDR
. ... |...| ... .|||. .    
vyakrltaekaiklvrskrpksiqtre
subfamily_STYXL1_pd Subfamily STYXL1 52-157 2e-12 40.6 In-house 37-136 (157) alignment 
Range on Protein: 52-157
Range on HMM: 37-136/157.0
NVKGVISLNEDHELrrhapTVEEWKNhGIEHLQLPTVDFTEAPSLEYLERGVEFIQQHANDGSSVYVHCKAGRTRSATLVGCYLMMMNHCTPQEAQTFME
 ||... .  | .       .. ...   . |...  |  ||  || |.. |.||..| ..|. | |  . | .|||... .|||  .. | ..| ....
kvkahvnvsmdadk.....liagvad.vakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiaylmyskkitlkkaykylk

AKRPHI
  .. .
kCkenv
subfamily_RNGTT_pd Subfamily RNGTT 50-180 4.3e-12 40.1 In-house 52-181 (189) alignment 
Range on Protein: 50-180
Range on HMM: 52-181/189.0
EENVKGVISLNEDHELRrhapTVEEWKNHGIEHLQLPTVDFTEAPSLEYLERGVEFIQQHA--NDGSSVYVHCKAGRTRSATLVGCYLMMMNHCTPQEAQ
....  || | ...       . || ...||.. .| .    |||. |  ..  . ....   |  . . |||. |  |.  |. .||.  ...  ..| 
kvklglvidltntsryY....dkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaav

TFMEAKRPHILLKDRHFRALYRYYDKHVK-KARP
.     ||  . |. . . |.| |..  .  | |
alFakaRppGiykedylkellrrYadveeaiaap
subfamily_LRR-DSP_pd Subfamily LRR-DSP 92-173 9.4e-12 38.6 In-house 177-256 (263) alignment 
Range on Protein: 92-173
Range on HMM: 177-256/263.0
EAPSLEYLERGVEFIQQHANDGsSVYVHCKAGRTRSATLVGCYLMMMNHCTPQEAQTFMEAKRPHILLKdRHFRALYRYYDK
||    ..|.   ||..  . |  | |||.|| .||.||| .|||. .. . .||  ..  |||.|    . |.   . |.|
eadisqhfeetnafieeGrkkG.GvlvhcraGvsrsstlvisylmkkqrlkfkealdlvikkrpriqPn.pGfkdqlkkyek
subfamily_MKPLT_pd Subfamily MKPLT 34-156 1.4e-11 38.2 In-house 23-142 (164) alignment 
Range on Protein: 34-156
Range on HMM: 23-142/164.0
VILGALPFRSYIDQLKEENVkgVISLNEDHELRRHAPTVEEWKnHGIEHLQLPTVDFTEAPSLEYLERGVEFIQQHANDGSSVYVHCKAGRTRSATLVGC
|.|    ..   .. ..|.|  .  |. .| .     . . .  . .|.||. . | ..    ..|||  .|. .  . |  |.|||  |..||..    
vvledtlylGnakhatnekv..lkdlkithivnvsqekkdafp.ksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtva

YLMMMNHCTPQEAQTFMEAKRPH
.|.  .  | .||  ..  .|  
fLikskgwtlkeayeylkerrsi
subfamily_MKPLV_pd Subfamily MKPLV 34-156 1.4e-11 38.2 In-house 23-142 (164) alignment 
Range on Protein: 34-156
Range on HMM: 23-142/164.0
VILGALPFRSYIDQLKEENVkgVISLNEDHELRRHAPTVEEWKnHGIEHLQLPTVDFTEAPSLEYLERGVEFIQQHANDGSSVYVHCKAGRTRSATLVGC
|.|    ..   .. ..|.|  .  |. .| .     . . .  . .|.||. . | ..    ..|||  .|. .  . |  |.|||  |..||..    
vvledtlylGnakhatnekv..lkdlkithivnvsqekkdafp.ksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtva

YLMMMNHCTPQEAQTFMEAKRPH
.|.  .  | .||  ..  .|  
fLikskgwtlkeayeylkerrsi
subfamily_DSP23_pd Subfamily DSP23 48-156 1.7e-10 35.7 In-house 27-127 (148) alignment 
Range on Protein: 48-156
Range on HMM: 27-127/148.0
LKEENVKGVISLNEdhelrRHAPTVEEWKNHGIEHLQLPtvDFTeAPSLEYLERGVEFIQQHANDGSSVYVHCKAGRTRSATLVGCYLMMMNHCTPQEAQ
| .  |. ..|| |     .  | ||   |  . .|...  |..  |.|| ... |. ...  . . .| |||  || |. |.. |||. ... .  || 
lldlgvrylvslte.....egrphveatpnltlvrlrid..dyh.ppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeai

TFMEAKRPH
. .  .|| 
aevrrlrpg
subfamily_PTEN_pd Subfamily PTEN 90-155 6.1e-10 34.4 In-house 89-157 (184) alignment 
Range on Protein: 90-155
Range on HMM: 89-157/184.0
FTEAPSLEYLERGVEFIQQHA--NDGSSVYVHCKAGRTRSATLVGCYLMMMNHCTPQ-EAQTFMEAKRP
  ..|.|| ||. || |...   ..   | ||||||. |. .|. .||. ..... . || .. ...| 
DhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRt
PTPc_DSPc_SM00012 74-165 1.1e-09 33.8 In-house 9-97 (105) alignment 
Range on Protein: 74-165
Range on HMM: 9-97/105.0
EWKNHgiehlQLPTVDfteAPSLEYLERGVEFIQQHANdGSSVYVHCKAGRTRSATLVGCYLMMMNHCTPQ-EA-----QTFMEAKRPHILLKDRHFR
.|..|     ..|.      . ||.|.   .. ..... ...| |||.||  |..|.|  ......... . |         .  .||.    .. . 
gwpdh.....gvPees...dsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqyl
subfamily_STYX_pd Subfamily STYX 41-170 2.8e-09 30.3 In-house 28-153 (166) alignment 
Range on Protein: 41-170
Range on HMM: 28-153/166.0
FRSYIDQLKEENVKGVISLNEDHELRRHAPTVEEwknhGIEHLQLPTVDFTEAPSLEYLERGVEFIQQHANDGSSVYVHCKAGRTRSATLVGCYLMMMNH
 .| ...||.. .  .. . .. |     |  ..     . .| |   | |    . || .  |||..  . |  | || .|| .|||.|| .|.|    
mksklevlkkhgithivcirqnieanlikpnfpd....rfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalviayimetyg

CTPQEAQTFMEAKRPHILLKDRHFRALYRY
   .|| .... .|  |  ..   . |  |
lkyreafayvqerrfcinpnegfvsqlkey
subfamily_DSP11_pd Subfamily DSP11 72-170 3.4e-09 30.8 In-house 72-173 (178) alignment 
Range on Protein: 72-170
Range on HMM: 72-173/178.0
VEEWKNHGIEHLQLPTVDFtEAPSLEYLERG----VEFIQQHANDGSSVYVHCKAGRTRSATLVGCYLMMMNHCTPQEAQTFMEAKRPHILLKDRHFRAL
 .|....|...|.| ..   | |. | ...      ||......... . |||  |  |.  |.  ||. ..   |..|   .|  | | | .. . ..|
kkeltdegvkylklncpGh.evpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhslerenylkdL

YRY
.. 
kkl
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 75-170 1.4e-08 28.0 In-house 42-137 (145) alignment 
Range on Protein: 75-170
Range on HMM: 42-137/145.0
WKNHGIEHLQLPTVDFTEAPSLEYLERGVEFIQQHANDGSSVYVHCKAGRTRSATLVGCYLMMMNHCTPQEAQTFMEAKRPHILLKDRHFRALYRY
 |.. || | . . |.      ....   .||..  ..|. |.||| || .|| |.   .||     |  ||   ....|       . ...|.. 
lksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkycnmtlseaarqvrsnrllaypnvtflknllnl
subfamily_Auxilin_pd Subfamily Auxilin 110-168 1.4e-07 24.4 In-house 99-158 (166) alignment 
Range on Protein: 110-168
Range on HMM: 99-158/166.0
ANDGSSVYVHCKAGRTRSATLVGCYLMMMNH-CTPQEAQTFMEAKRPHILLKDRHFRALY
..  . | |||| ||. ||.||. .|. ..   .|..| ... .||  | |.. ..| |.
kdpknvvvvhckDGraasavlvsallvfcrllsepesavrlfsvkrlpiglspsekryle
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 80-168 2e-07 24.5 In-house 56-146 (154) alignment 
Range on Protein: 80-168
Range on HMM: 56-146/154.0
IEHLQLPTVDFTEAPSLEYLERGVEFIQQHA--NDGSSVYVHCKAGRTRSATLVGCYLMMMNHCTPQEAQTFMEAKRPHILLKDRHFRALY
||.|.|   | ..   .| |..  |||..     . . | ||...| .|||.|.  |||   . .  .|  ..   |. |       . | 
ieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaallisylmdklkislslalellkdsryiikPnqGflkqle
Y_phosphatase Protein-tyrosine phosphatase 72-154 3.6e-07 25.2 Pfam-A 140-216 (235) alignment 
Range on Protein: 72-154
Range on HMM: 140-216/235.0
VEEWKNHGIEHLQLPTVDFTEAPSLEYlergvefiqqhANDGSSVYVHCKAGRTRSATLVGCYLMMMNHCT-----PQEAQTFMEAKR
...|..||.   . . .|. ..   .            ... ..| |||.||  |..|.|   .....  .       ..   . ..|
ytnWpdhgvpespkslldlirkveksk...........eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqR
Y_phosphatase Protein-tyrosine phosphatase 72-154 3.6e-07 25.2 In-house 140-216 (235) alignment 
Range on Protein: 72-154
Range on HMM: 140-216/235.0
VEEWKNHGIEHLQLPTVDFTEAPSLEYlergvefiqqhANDGSSVYVHCKAGRTRSATLVGCYLMMMNHCT-----PQEAQTFMEAKR
...|..||.   . . .|. ..   .            ... ..| |||.||  |..|.|   .....  .       ..   . ..|
ytnWpdhgvpespkslldlirkveksk...........eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqR
subfamily_PRL_pd Subfamily PRL 42-169 5.2e-07 23.8 In-house 24-144 (151) alignment 
Range on Protein: 42-169
Range on HMM: 24-144/151.0
RSYIDQLKEENVKGVISLNEDhelrrhAPTVEEWKNHGIEHLQLPTVDfTEAPSLEYLERGVEFIQQH--ANDGSSVYVHCKAGRTRSATLVGCYLMmMN
 ..|..||.|.|| |.   |       .  .|. ...||| |.|.  |   .|. | .|. .| ....   . .|.| ||| ||  |.  ||   |.  .
ekfieelkkeevktvvrvcep......tydteklekegievldlafdd.GavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalali.ea

HCTPQEAQTFMEAKRPHILlKDRHFRALYR
  ....|  |.  ||   .   . .. | .
Gmkyedavefirekrrgai.nskqlkflek
DSPc_SM00195 68-145 7.2e-07 24.2 In-house 161-227 (263) alignment 
Range on Protein: 68-145
Range on HMM: 161-227/263.0
HAPTVEEWKNHGIEHLQLPTVDFTEAPSLEYLERgvefiqqhandGSSVYVHCKAGRTRSATLVGCYLMMMNHCTPQE
.   ...|..||. . . ..... .|   .. .             . . |||.||  |..|.|   ... . .. ..
tqyqyknWpdhgvpdstksvlellravkksksts...........sgpivVhCsaGvgRtgtfvtidiilskleeekk
PTPc_SM00194 68-145 7.2e-07 24.2 In-house 161-227 (263) alignment 
Range on Protein: 68-145
Range on HMM: 161-227/263.0
HAPTVEEWKNHGIEHLQLPTVDFTEAPSLEYLERgvefiqqhandGSSVYVHCKAGRTRSATLVGCYLMMMNHCTPQE
.   ...|..||. . . ..... .|   .. .             . . |||.||  |..|.|   ... . .. ..
tqyqyknWpdhgvpdstksvlellravkksksts...........sgpivVhCsaGvgRtgtfvtidiilskleeekk
DSPn Dual specificity protein phosphatase, N-terminal half 116-156 1.4e-06 19.0 Pfam-A 70-113 (141) alignment 
Range on Protein: 116-156
Range on HMM: 70-113/141.0
VYVHCK---AGRTRSATLVGCYLMMMNHCTPQEAQTFMEAKRPH
... ..     |...|.|.|.|...... .|.||   .|.. |.
ivlytsldekkranaalLigaYavivlklspeealkplesveps
Y_phosphatase2 Tyrosine phosphatase family 99-167 6.8e-06 18.0 Pfam-A 79-145 (165) alignment 
Range on Protein: 99-167
Range on HMM: 79-145/165.0
LERGVEFIQQHANdgSSVYVHCKAGRTRSATLVGCYLMMMNHCTPQEAQTFMEAKRPHILLKDRHFRAL
|.. .... ...|    |..||| |. | ....||   ... .. .  . .    ...    |..| . 
lkkalklllnken..ypvllhckrGkhrtglvigclRklqkWslasilnEyrrFsgskkrivdeefien