Gene RNGTT in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily RNGTT
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP025_AA protein Get Run
SpurP025_AA_12-181 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_RNGTT_pd Subfamily RNGTT 5-191 5.5e-94 307.2 In-house 1-188 (189) alignment 
Range on Protein: 5-191
Range on HMM: 1-188/189.0
PERWLNCPRKGTLIAGKFLPFKTPLGPKYNDSIPEENRFDTSMLFAYMNSRQVKLGWVFDLTNTNRFYDKDEIEKNGARHIKLPCRGRGECPSKEQTSLF
|||||||||||.|||.|||||||||...|.|...|||||..|||..|.....||||.|.|||||.|.|||.|.||.|....|| |.|.||.|..||.. |
PerWlnCPrkgkliaekflpfktplskrydddlaeenrfepsmllsylktlkvklglvidltntsryYdkeelekegikyvklqcagkgeaPeaeqvkef

IQMCST-NCKNPDQIIGVHCTHGYNRTGFLICAYLVETLDWSVDAAVSLFAQGRPPGIYKGDYIQELFDRYGDVSEAPPPPDLPDWCV
|..... ..|||...||||||||.|||||||..||||. ||||.|||.|||. |||||||.||..||..||.||.||...|.|||||.
iklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiykedylkellrrYadveeaiaapelpdwcl
mRNA_cap_enzyme mRNA capping enzyme, catalytic domain 261-447 6.6e-63 201.2 Pfam-A 1-192 (192) alignment 
Range on Protein: 261-447
Range on HMM: 1-192/192.0
QPVSMDRNNINFLKKNYYWVSWKADGIRYMMLIDGPgEVYLFDRDHVVFSAPHLSFPNRKG-----PHRDTLVDGEMIIDTVDGKSVARYLIYDIIKYWG
||||..|.|...||...| ||.||||.|...||.   ||||.|||. |.  ..| ||...       | .||.|||..|||| .... |||||||... |
qpvslsrenlkllkqkdYyvseKaDGlRvlllitkk.evylidrdnevylvenlkfplklekekekvhhgtllDGElvidtveeeqklryliyDilaing

KPVGGCDFGWRRRCIQDEIIAPREVE-LQKGSIDRMREPFGIREKPFWDITSSKKILDGSFSQELMHETDGLIFQPHKDPYIPGRCDLILKWK
. |  ...  |  ... ||| ||. | |... |.   ||| .| | |...  ..|.|. .. ..|.||.||||||. ..||..||.. .||||
elvserplskRleilkkeiikpraeeklkthiiktelepfkvrlksfilllalekllskkkikklsheiDGLIfqsvdtpYvagrdknllKWK
0038934 (Phosphotyrosine protein) phosphatases II 4-193 4.4e-58 191.4 In-house 2-192 (194) alignment 
Range on Protein: 4-193
Range on HMM: 2-192/194.0
VPERWLNCPRKGTLIAGKFLPFKTPLGPKYNDSIPEENRFDTSMLFAYMNSRQVKLGWVFDLTNTNRFYDKDEIEKNGARHIKLPCRGRGECPSKEQTSL
.|.|||...| |..| |.|..||.||   ... |.|..||. ..|. |.....||||.| |||||.|.||..|.||.| ...|||. ..|..|| |..  
lPdrwlkyervgdiitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillr

FIQMCSTN-CKNPDQIIGVHCTHGYNRTGFLICAYLVETLDWSVDAAVSLFAQGRPPGIYKGDYIQELFDRYGDVSEAPPPPDLPDWCVGA
|.... .   ..|.....|||..|..|||.|..|||...|..|...|. ||.. ||..|.. ||...|. ||... .|. .|. |....  
fldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykelrkavlapekpellled
subfamily_DSP11_pd Subfamily DSP11 4-173 1.9e-43 142.4 In-house 1-173 (178) alignment 
Range on Protein: 4-173
Range on HMM: 1-173/178.0
VPERWLNCPRKGTLIAG-KFLPFKTPLGPKYNDSIPEENRFDTSMLFAYMNSRQVKLGWVFDLTNTNRFYDKDEIEKNGARHIKLPCRGRGEcPSKEQTS
||.|| .    |. | | .|..|||||  .... ..||.|| .. |.  ..... ||| | |||||.|.|.|.|....| .. || | |.   |..|  .
vPdrwkkykpvgdkiegtrfiafktPlkesfdkkveeekrftpkdLleklqeknkklGLvidltntdryykkkeltdegvkylklncpGhev.pkeelvk

LFIQMCST---NCKNPDQIIGVHCTHGYNRTGFLICAYLVETLDWSVDAAVSLFAQGRPPGIYKGDYIQELFDR
 |... .    ..|. |..|||||||| ||||.||| ||... ... . |.. | . |   . . .|...| ..
kfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhslerenylkdLkkl
mRNA_cap_C mRNA capping enzyme, C-terminal domain 451-547 1.5e-30 95.0 Pfam-A 2-104 (105) alignment 
Range on Protein: 451-547
Range on HMM: 2-104/105.0
LNSVDFRIKVTVVKREGCIPETLGLL-FVGGQQQPF----GQMKITKDLKQYDNKIIECSYNN-KKGWQFMRERTDKSFPNGYKTAVAVCQSIQNPVTKD
||.|||..|..  ...| ..|. |.| .| |....|     ..|...|.|....||.||.... |. |.|.|.|.||| ||...|| .|..||...|||.
lntvDfllklekeeedglLeeekgkldyveggsdefitakekeklksdekelkgkIvEcklddkkgrWkflriRkDKsepNsistaekvlksiednvtke

FLM
 |.
eLl
0049772 (Phosphotyrosine protein) phosphatases II 47-174 2.3e-21 72.3 In-house 167-269 (314) alignment 
Range on Protein: 47-174
Range on HMM: 167-269/314.0
MlfaymnsrqvklgwvfdltntNRFYDKDEIEKNGARHIKLPCRGrGECPSKEQTSLFIQMCSTNckNPDQIIGVHCTHGYNRTG-FLICAYLVETLDWS
                      .. ||..  |..| ... .|. . |..|. |.   |.... ..  ...  . |||..| .||| |...|||.  |..|
k.....................eelydpelferlgikylripvpD.gsaplledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllgvs

VDAAVSLFAQGRPpgIYKGDYIQELFDRY
.. |.. . . ||  |.  .   | ...|
leealedvrlkRp..inpnpgfieqleqy
0049260 (Phosphotyrosine protein) phosphatases II 58-174 2.7e-21 71.3 In-house 31-146 (152) alignment 
Range on Protein: 58-174
Range on HMM: 31-146/152.0
KLGWVFDLTNTNRFYDKDEIEKNGARHIKLPCRGRGECPSKEQTSLFIQMCSTNCKNPDQIIGVHCTHGYNRTGFLICAYLVEtLDWSVDAAVSLFAQGR
.||    .. |...... . .... ... ||.   | ... .    .....   .....  . |||..| .|||.|..|||.. |..|.. ||.|. . |
elgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.lgvsleeavalvrekR

PPGIYKGDYIQELFDRY
| ...  .... |....
pgavpnpgqlrflyefe
0044763 (Phosphotyrosine protein) phosphatases II 56-172 4.8e-21 70.6 In-house 46-165 (178) alignment 
Range on Protein: 56-172
Range on HMM: 46-165/178.0
QVKLGWVFDLTNTNRFY----DKDEIEKNGARHIKLPCRGRGECPSKEQTSLFIQMCSTNCKNPDQIIGVHCTHGYNRTGFLICAYLVETLDWSVDAAVS
. ... . .||.. . .    |.   |..| .....|. . |.... |..  |.... .  ....  . |||..|..|.| |..|||. .|..|...|..
elgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaie

LFAQGRPpGIYKGDYIQELFD
|. . || ...  .... | .
lvrerRp.ivpnpgqlrqLye
0036282 (Phosphotyrosine protein) phosphatases II 14-172 7.2e-21 70.1 In-house 11-164 (174) alignment 
Range on Protein: 14-172
Range on HMM: 11-164/174.0
KGTLIAGKFLPFKTPLGpkyndSIPEENRFDTSMLFAYMNSRQVKLGWVFDLTNTnrfyDKDEIEKNGARHIKLPCRGRGECPSKEqTSLFIQMCSTNCK
... | .... .. ||       ...  ... .... ...... .|.........    ...  |..| ....||. ..|. .. .    |.. . . ..
dlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....lredlerlgiqylylpwpDhgvpdlsi.llefvkfveeals

N-PDQIIGVHCTHGYNRTGFLICAYLVETLDW-SVDAAVSLFAQGR---PPGIYKGDYIQELFD
. |.  . |||..| .|||.|..|||.... . |.. |..|... |   |....  .... | .
edpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyy
PTEN_1 2-170 1.8e-20 68.6 In-house 13-184 (196) alignment 
Range on Protein: 2-170
Range on HMM: 13-184/196.0
LAVPERWLNCPRKGTLIAGKFLPFKTPLGPKYNDSIPEENRFDTSMLFAYMNSRQVKLGWVFDLTNTN--RFYDKDEIEKNGARHIKLPCRGRGECPSKE
|| |...|....  . | ... .. .||  .. ..  .... | ....  . .. . | . ...   .  | ||..| .|.| .....| .  | ..  |
lalptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslse

QTSLFIQMCSTNCKNP-DQIIGVHCTHGYNRTGFLICAYLVETLDWSVDAAVSLFAQGRPPGIYKGDYIQEL
      .. .   ..|   .. |||..| .|.|....|||...  ...| |..|... ||||     . ..|
lfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerl
0043147 (Phosphotyrosine protein) phosphatases II 20-170 3.4e-20 67.9 In-house 20-153 (172) alignment 
Range on Protein: 20-170
Range on HMM: 20-153/172.0
GKFLPFKTPlgpkyndsipeeNRFDTSMLFAYMNSRQVKLgwVFDLTntNRFYDKDEIEKNGARHIKLPCRGRGECpSKEQTSLFIQMCST-NCKNPDQI
 .|...  |             |..... .... ......  ...||  ...||..  |..| ... ||.   | . . |.   |.. . .  ...|.  
drfiatqgp............lrntladfwrmlkelgith..ivnlt..ellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggp

IGVHCTHGYNRTGFLICAYLVEtLDWSVDAAVSLFAQGRPPGIYKGDYIQEL
. |||..| .|||.|..|||.. |..|.. ||.|. . || ...  .... |
vlVHCsaGvgRtgtlvaaylml.lglsleeavalvrekRpgavqnpsqyrfl
0041856 (Phosphotyrosine protein) phosphatases II 56-162 8.1e-20 66.6 In-house 56-155 (182) alignment 
Range on Protein: 56-162
Range on HMM: 56-155/182.0
QVKLGWVFDLTntNRFYDKDEIEKNGARHIKLPCRGRGECPsKEQTSLFIQMCSTncknPDQIIGVHCTHGYNRTGFLICAYLVETLDWSVDAAVSLFAQ
. . ... .||  .. |. .. |..| ....||. . | ..  ...  ||...      ..  . |||..| .|||.|..|||...|..|.. ||.|. .
elgittivnlt..eelywpellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrs

GRPPGIY
 || .. 
rRpgmvi
0048179 (Phosphotyrosine protein) phosphatases II 52-172 2e-19 65.2 In-house 23-139 (144) alignment 
Range on Protein: 52-172
Range on HMM: 23-139/144.0
MNSRQVKLGWVFDLTNTnrfYDKDEIEKNGARHIKLPCRGRGECPSKEQTSLFIQMCSTNCKnPDQIIGVHCTHGYNRTGFLICAYLVETLDWSVDAAVS
 . .. ....|..||..   |.... |..| ....||. ..|  .. |.   |.... .  . ..  . |||..|..|||.|..|||. .|..|.. |. 
ellkklgittvinltee...yepefleregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylmkklglsleeala

LFAQGRPPGIYKGDYIQELFD
|. . || ...  .... | .
lvrsrrpgavpnpgqlrfLle
0048076 (Phosphotyrosine protein) phosphatases II 54-174 2.2e-19 65.0 In-house 25-139 (145) alignment 
Range on Protein: 54-174
Range on HMM: 25-139/145.0
SRQVKLGWVFDLtntnrFYDKDEIEKNGARHIKLPCRGRGECPSKEQTSLFIQMCSTNCKNPdQIIGVHCTHGYNRTGFLICAYLVETLDWSVDAAVSLF
 .. ....|..|      ....  |..| ... ||. ..|. .. |.   |.... .  |..   . |||..|..|||.|..|||. .|..|.. |. |.
lkdlgittvlnl.....tselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmlllgvsleealelv

AQGRPPGIYKGDYIQELFDRY
 . || ...  .... |.. .
rsqrpgavpnpgqlrflyefe
0040439 (Phosphotyrosine protein) phosphatases II 56-170 6.3e-18 60.7 In-house 76-238 (249) alignment 
Range on Protein: 56-170
Range on HMM: 76-238/249.0
QVKLGWVFDLTNTNRF-------------------------------------------YDKDEIEKNGARHIKLPcrGRGECPSKEQTSLFIQMCSTNC
. . . . .||.. ..                                           ||..... .. .....|    | .|| |..  ||... . .
elgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp..dhgvppsfedlldfieavrkal

KN--PDQIIGVHCTHGYNRTGFLICAYLV-----ETLDWSVDAAVSLFAQGRPPGIYKGDYIQEL
..  ..  . |||..| .|||..|.|||.     ..|..... ||.|. . || ...  .... |
eelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrfl
0051082 (Phosphotyrosine protein) phosphatases II 55-161 1.3e-17 59.2 In-house 30-136 (151) alignment 
Range on Protein: 55-161
Range on HMM: 30-136/151.0
RQVKLGWVFDLTNTN-RFYDKDEIEKNGARHIKLPCRGRGECPSKEQTSLFIQMCSTNCKNPDQIIGVHCTHGYNRTGFLICAYLVEtLDWSVDAAVSLF
.. .. ....|...  | |...  ...| ... .|. .  . .  . .  .... .   ..... . |||..| .|||.|...||.  |..|...|.. .
kelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylml.lgvsleealeey

AQGRPPGI
 . ||  .
rlkrpgvv
0040438 (Phosphotyrosine protein) phosphatases II 56-178 2.2e-17 58.8 In-house 108-283 (317) alignment 
Range on Protein: 56-178
Range on HMM: 108-283/317.0
QVKLGWVFDLTNTNRFYD----------------------KDEIEKNGARHIKLPCRGR------------------GECP-SKEQTSLFIQMCSTNCKN
. ... .  ||..  . .                      ..|.|..|  . .|.. .                   . .| | ..   |.... .....
eqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealed

PDQIIGVHCTHGYNRTGFLICAYLV-----ETLDWSVDAAVSLFAQGRPPGIYKGD-------YIQELFDRYGDVS
|.  . |||..| .|||..|.|||.     .. ...|. ||  . . || ...  .       ...|.. |..   
pggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltle
0037934 (Phosphotyrosine protein) phosphatases II 54-164 2e-16 55.7 In-house 69-228 (243) alignment 
Range on Protein: 54-164
Range on HMM: 69-228/243.0
SRQvKLGWVFDLTNTN----------------------------------------RFYDKDEIEKNGARHIKLPCRGRGECPSKEQTSLFIQMCSTN--
 .. . ... .||..                                         . .| |. .... ..  ||  . |  .| |.   |.... .   
wel.gitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefie

------CKNPDQIIGVHCTHGYNRTGFLICAYLVETL-DWSVDAAVSLFAQGRPP-GIYKG
      . ...  . |||..| .||| ||.|||. .| ..... || |. . ||  ..   
ellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtp
0042113 (Phosphotyrosine protein) phosphatases II 56-168 6.9e-15 50.6 In-house 74-233 (245) alignment 
Range on Protein: 56-168
Range on HMM: 74-233/245.0
QVKLGWVFDLTNTNRFYD-----------------------------------------KDEIEKNGARHIKLPCRGRGECPSKEQTSLFIQMCSTNCK-
. ..  ...||..  .                                           .|  .... ..  ||. . |.... |.   |.... . .. 
elgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae

NPDQIIGVHCTHGYNRTGFLICAYLV-----ETLDWSVDAAVSLFAQGRPPGIYKGDYIQ
...  . |||..| .||| .|.|||.     ..|..|.. ||  . . ||  .   ....
dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyr
0046846 (Phosphotyrosine protein) phosphatases II 56-160 1.4e-14 49.8 In-house 45-154 (176) alignment 
Range on Protein: 56-160
Range on HMM: 45-154/176.0
QVKLGWVFDLTNT------NRFYDKDEIEKNGARHIKLPCRGRGECPSkEQTSLFIQMCSTNCKNPdQIIGVHCTHGYNRTGFLICAYLVET-LDWSVDA
. . . |..||.       . ... .|.||.| ... || .  | ... |.   ..... .  |.  . . ||| .| .||| |..|||.|.  ..||. 
elgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllelekglsvee

AVSLFAQGRPPG
|..|. . ||.|
alalvreqRplg
0045098 (Phosphotyrosine protein) phosphatases II 53-165 3.1e-14 48.5 In-house 127-259 (278) alignment 
Range on Protein: 53-165
Range on HMM: 127-259/278.0
NSRQVKLGWVFDLTNTNRFYDKDEIEKNGARHIKLPCRGRGECPSKEQTSLFIQMCS--TNCKN--------------PDQIIGVHCTHGYNRTGFLICA
.  ...  .. .|. || .. . ..|..| .|.....   ...|| . .. |....    .. .              ..  . ||| .| .||| |..|
seevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaa

YLVETL---DWSVDAAVSLFAQGRPP-GIYKGD
||. .|    .... ||. . . ||   .   .
ylmlelleggvdlleavkelrsqRpglavqnle
0045450 (Phosphotyrosine protein) phosphatases II 58-168 8.4e-14 47.5 In-house 131-294 (307) alignment 
Range on Protein: 58-168
Range on HMM: 131-294/307.0
KLGWVFDLTNTN-------------------------RFYDKDEIEKNGARHIKLPCR------------------GRGECPSKEQTSLFIQMCSTNCKN
. . . .||..                          ....... ..   |.... .                   . | .|| |..  ||... . ...
gvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkalee

--PDQIIGVHCTHGYNRTGFLICAYLVETLD--------WSVDAAVSLFAQGRPPGIYKGDYIQ
  ..  . |||..| .||| .|.|||. ..         .... ||.|. . || ..   ....
lpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyr
0043336 (Phosphotyrosine protein) phosphatases II 59-163 3.1e-13 45.3 In-house 156-262 (278) alignment 
Range on Protein: 59-163
Range on HMM: 156-262/278.0
LGWVFDLTNTNrFYDKDEIEKNGARHIKLPcrGRGECPSKEQTSLFIQMCSTNCKNPDQIIGVHCTHGYNRTGFLICAYLV-----ETLDWSVDAAVSLF
  .|..|. ||  .|. . . ..  ... |    | ..| ..   |...  . .....  . |||..| .||| .|..||.      .. .... ||. .
dytvrtlevtn.lgdgesrtvthyhylgwp..dhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkel

AQGRPPGIYK
 . ||  .  
reqRpgavqt
0051429 (Phosphotyrosine protein) phosphatases II 49-175 6.5e-13 44.5 In-house 38-229 (272) alignment 
Range on Protein: 49-175
Range on HMM: 38-229/272.0
FAYMnsRQVKLGWVFDLTNTNRFYDKD-EIEKNGARHIKLPCRGRGECPSK-------------------------------------------------
|...  .. ..  ..||....     . . .  |.|.. ||. .... .                                                   
fwrl..kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgv

--EQTSLFIQMCSTncknpDQIIGVHCTHGYNRTGFLICAYLVEtLDWS--------------VDAAVSLFAQGRPPGIYKGD-------YIQELFDRYG
  |.   ..... .     .. . |||..| .|||......|.  |..|              ...||.   . ||  .   .       ...||.... 
pqeallellellld.....ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrsll
DSPc Dual specificity phosphatase, catalytic domain 61-170 1.8e-12 42.3 Pfam-A 21-127 (133) alignment 
Range on Protein: 61-170
Range on HMM: 21-127/133.0
WVFDLTNTNR-FydkDEIEKNGARHIKLPCRGrgecPSKEQTSLFIQMCST---NCKNPDQIIGVHCTHGYNRTGFLICAYLVETLDWSVDAAVSLFAQG
 |...|....      .|.|.  .....| .      .....| .......   ....  . . |||..|..|.. ||.||| .|  .|.. |.... . 
lvinvtkevpnn...naikkseieylripved....etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvker

RpPGIYKG-DYIQEL
| . | .   ....|
r.skispnagflrqL
DSPc Dual specificity phosphatase, catalytic domain 61-170 1.8e-12 42.3 In-house 21-127 (133) alignment 
Range on Protein: 61-170
Range on HMM: 21-127/133.0
WVFDLTNTNR-FydkDEIEKNGARHIKLPCRGrgecPSKEQTSLFIQMCST---NCKNPDQIIGVHCTHGYNRTGFLICAYLVETLDWSVDAAVSLFAQG
 |...|....      .|.|.  .....| .      .....| .......   ....  . . |||..|..|.. ||.||| .|  .|.. |.... . 
lvinvtkevpnn...naikkseieylripved....etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvker

RpPGIYKG-DYIQEL
| . | .   ....|
r.skispnagflrqL
0039614 (Phosphotyrosine protein) phosphatases II 58-167 1.9e-12 42.8 In-house 125-278 (297) alignment 
Range on Protein: 58-167
Range on HMM: 125-278/297.0
KLGWVFDLTNTNRF--------------------YDKDEIEKNGARHIKLPC-----------------RGRGECPSKEQTSLFIQMCSTNCKN--PDQI
.   .  ||...                      . .......|  . .|.                     | .|| |.   |.... . ...  ..  
gvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggp

IGVHCTHGYNRTGFLICAYLV-----ETLDWSVDAAVSLFAQGRPPGIYKGDYI
. |||..| .||| .|.|||.     .. ...|. ||. . . || ..   ...
vlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqy
0048567 (Phosphotyrosine protein) phosphatases II 74-165 2.5e-11 38.2 In-house 62-126 (157) alignment 
Range on Protein: 74-165
Range on HMM: 62-126/157.0
KdeiekngarhiklpcrgrgecpskeqtslfI----QmcstNCKNPDQIIGVHCTHGY---NRTGFLICAYLVETLDWSVDAAVSLFAQGRPPGIYKGD
|                              .    .     ... .. | |||..|.    ||..||..||.  |... . |. .... ||. ..  |
k..............................lnkflk....ilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrd
PTPc_motif_SM00404 111-171 6.7e-11 37.2 In-house 75-135 (140) alignment 
Range on Protein: 111-171
Range on HMM: 75-135/140.0
NCKNPDQIIGVHCTHGYNRTGFLICAYLVETLDWSVDAAVSLFAQGRpPGIYKG-DYIQELF
|...  . . |||..|..|.. ||.||| ..  .|...|.... . | | | .   ....|.
naekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeayefvkerR.piispnlnfvrqLi
subfamily_CDC14_pd Subfamily CDC14 16-158 1.2e-10 35.8 In-house 174-305 (328) alignment 
Range on Protein: 16-158
Range on HMM: 174-305/328.0
TLIAGKFLPFKTPlgpKYNDSipEENRF---DTSMLFAYMNSRQVKLgwVFDLTNTnrFYDKDEIEKNGARHIKLPCRgRGECPSKEQTSLFIQMCSTNc
... .||| .  |   . .    .|...       |. |.....|.   |  | .    ||. . ...|  |  |     | .||..    |.... .  
wivPdkflalagP...hnksk..ledgyplhaPeklleyfrknnvtt..vvrLnkk..lYdakkftdaGfdhkDlffi.DGstPsdaivkkfleiaeka.

knpDQIIGVHCTHGYNRTGFLICAYLVETLDWSVDAAVSLFAQGRP
   .  | |||  |  ||| || .||...   .   |.. .   ||
...eGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrP
0046845 (Phosphotyrosine protein) phosphatases II 65-162 6.7e-10 34.3 In-house 153-258 (284) alignment 
Range on Protein: 65-162
Range on HMM: 153-258/284.0
LTNTNRFYDKDEIEKNGARHIKLPcrGRGECPSKEQTSLFIQMCSTNCK--NPDQIIGVHCTHGYNRTGFLICAYLVETL--------DWSVDAAVSLFA
|. ||  |.. ... .   ... |   .| .|| |.   |.... . ..  ...  | ||| .| .||| .|...|. ..         ..|  ||. . 
leltnlgytgesrtvthfhytswp..dhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlr

QGRPPGIY
. ||  . 
eqRpgmvq
subfamily_PTPDC1_pd Subfamily PTPDC1 72-168 2.6e-09 31.8 In-house 73-166 (182) alignment 
Range on Protein: 72-168
Range on HMM: 73-166/182.0
YDKDEIEKNGARHIKLPCRGRGECPSkEQTSLFIQMCSTNCKNPdqIIGVHCTHGYNRTGFLICAYLVETLDWSVDAAVSLFAQGRPPGIYKGDYIQ
||.... ..|  . ... .  | ..  |.    ... .  ...    ..|||  |  ||| ||..||| . . . . |..|  . ||  |.  . ..
YdlealmeqgiyvynfgwkDygvasl.eriLdivkvvafalqeg..kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqve
0047943 (Phosphotyrosine protein) phosphatases II 94-162 2.8e-09 32.3 In-house 181-256 (273) alignment 
Range on Protein: 94-162
Range on HMM: 181-256/273.0
ECPSKEQTSLFIQMCSTNCKN--PDQIIGVHCTHGYNRTGFLICAYLV-----ETLDWSVDAAVSLFAQGRPPGIY
 .|| |.   ||... . ...   .  . ||| .| .||| .|...|.     ..  ..|. || |. . || ...
vppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvq
0051299 (Phosphotyrosine protein) phosphatases II 91-161 6.6e-09 31.1 In-house 194-269 (288) alignment 
Range on Protein: 91-161
Range on HMM: 194-269/288.0
GRGECPSKEQTSLFIQMCSTNCKNPDQIIGVHCTHGYNRTGFLICAYLV-----ETLDWSVDAAVSLFAQGRPPGI
  |  .| |.   |.... . .....  . ||| .| .||| .|...|.     ..  ..|  ||  . . ||  .
dhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmv
0050432 (Phosphotyrosine protein) phosphatases II 95-161 1.1e-08 30.2 In-house 212-282 (308) alignment 
Range on Protein: 95-161
Range on HMM: 212-282/308.0
CPS-KEQTSLFIQMCSTNCknPDQIIGVHCTHGYNRTGFLICAYLV-----ETLDWSVDAAVSLFAQGRPPGI
.|.  |.   |.... . .  |.  | ||| .| .||| .|...|.     ..  ..|  ||  . . ||  .
vPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmv
0036941 (Phosphotyrosine protein) phosphatases II 100-160 5.3e-08 28.0 In-house 189-259 (297) alignment 
Range on Protein: 100-160
Range on HMM: 189-259/297.0
QTSLFIQMCSTNCKN--PDQIIGVHCTHGYNRTGFLICAYLV--------ETLDWSVDAAVSLFAQGRPPG
.   ||... . .|.  ..  . ||| .| .|.| .|.|.|.        ..  ...  ||  . . ||  
slldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpga
subfamily_PRL_pd Subfamily PRL 70-152 2.1e-07 25.1 In-house 44-125 (151) alignment 
Range on Protein: 70-152
Range on HMM: 44-125/151.0
RFYDKDEIEKNGARHIKLPCRgRGECPSKEQTSLFIQMCSTN-CKNPDQIIGVHCTHGYNRTGFLICAYLVETlDWSVDAAVSL
  ||....||.| . . |.    |  |..|    ..... .. ...|.....|||  |  |.  |..  |.|.   . . ||..
ptydteklekegievldlafd.dGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalaliea.Gmkyedavef
subfamily_PTEN_pd Subfamily PTEN 113-157 2.5e-07 25.9 In-house 111-156 (184) alignment 
Range on Protein: 113-157
Range on HMM: 111-156/184.0
KNPDQIIGVHCTHGYNRTGFLICAYLVETLDWSVD-AAVSLFAQGR
....... |||  |  ||| ||.|||...| ..    |..|||. |
edkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaR
subfamily_DSP23_pd Subfamily DSP23 95-161 4.8e-07 24.5 In-house 64-129 (148) alignment 
Range on Protein: 95-161
Range on HMM: 64-129/148.0
CPSKEQTSLFIQMCStNCKNPDQIIGVHCTHGYNRTGFLICAYLVETLDWSVDAAVSLFAQGRPPGI
 |. ||   |...   . .. .. ..|||  |. ||| ..  |||   . .   |..   . ||  .
ppaleqvvefvrvve.eaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpgsv
DNA_ligase_A_M ATP dependent DNA ligase domain 273-339 1.3e-06 17.0 Pfam-A 17-87 (202) alignment 
Range on Protein: 273-339
Range on HMM: 17-87/202.0
LkKNYYWVSWKADGIRymMLID-GPGEVYLFDRDHVVFSA--PHL-SFPNR--KGPHRDTLVDGEMII-DTVDG
| .....|..| ||.|  . ..   .||.|. |    ..|  | |  . ..  .  ... ..|||... |.  |
l.egafiveeKyDGeR..vqvhkdgdevkllSRrgkditakkpellkalkeaflkdvksvildGElvavdketg
subfamily_DSP12_pd Subfamily DSP12 100-158 1.5e-06 22.7 In-house 70-124 (155) alignment 
Range on Protein: 100-158
Range on HMM: 70-124/155.0
QTSLFIQMCStnckNPDQIIGVHCTHGYNRTGFLICAYLVETLDWSVDAAVSLFAQGRP
..  ||. .     . .. . |||. |  |   .. |||. . ..|.. |..|  . .|
eavdFieeal....eeegavlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkp
subfamily_PTPMT1_pd Subfamily PTPMT1 75-158 4.9e-06 21.1 In-house 67-149 (171) alignment 
Range on Protein: 75-158
Range on HMM: 67-149/171.0
DEIEKNGARHIKLPCRGRGECPSKEQTSLFIQMCSTNCKNpDQIIGVHCTHGYNRTGFLICAYLVETLDWSVDAAVSLFAQGRP
.| .|.|  ...|.     | |. |. .  ... .   ..  . . |||  |  |.. |. .||. .  .| . |..  .. |.
eewkklgveqlqlatvDfteapdleklekgvefiekvask.gkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRk