Gene STYX in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily STYX
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP027_AA protein Get Run
SpurP027_AA_0-141 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_STYX_pd Subfamily STYX 1-142 1.1e-88 288.5 In-house 14-155 (166) alignment 
Range on Protein: 1-142
Range on HMM: 14-155/166.0
EILPGLYLGPYAAAQRSKLPVLLEHGITHVLCIRQAPEATIIKPNFPDRFRYLVLDVADNCMENIIRHIPTVKGFIDSCLQSGGRILVHGNAGISRSAAL
||||||.||||.||..|||.|| .|||||..||||..||..|||||||||||||||||||..|||||..||||.|||..||.||..||||||||||||||
eilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaal

VIGYLMETYGLKYRIAYRYVQEKRFCISVNDGFASQLKVFKI
||.|.|||||||||.|..||||.||||..|.||.||||....
viayimetyglkyreafayvqerrfcinpnegfvsqlkeyea
PTPc_motif_SM00404 1-140 1.5e-34 113.9 In-house 4-137 (140) alignment 
Range on Protein: 1-140
Range on HMM: 4-137/140.0
EILPGLYLGPYAAAQrsKLPVLLEHGITHVLCIRQAPEATiikpNFPDRFRYLVLDVADNCMENIIRHIPTVKGFIDSCLQSGGRILVHGNAGISRSAAL
.|||.|||| . .||  ....| ..|||||... .  ..|    .   .|..| ... ||  ... .... |. ||... ..||..|||  ||.||||.|
rilphlylgskskaq..npallkklgithvinvteevslt....kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatl

VIGYLMETYGLKYRIAYRYVQEKRFCISVNDGFASQLKVF
.| |||....|... ||..|.|.| .|| | .|  ||  .
iiaYlmryrqlslaeayefvkerRpiispnlnfvrqLiey
subfamily_DSP19_pd Subfamily DSP19 2-140 4.4e-34 112.0 In-house 15-146 (152) alignment 
Range on Protein: 2-140
Range on HMM: 15-146/152.0
ILPGLYLGPYAAAQRSKlpVLLEHGITHVLCIrqapeATIIKPNFPDRFRYLVLDVADNCMENIIRHIPTVKGFIDSCLQSGGRILVHGNAGISRSAALV
. | ||||   .|. ..   | |..|||.| .     || ..  ||. | || ... |.  .......... .||.. ... |..||| |||.||||..|
veprlylgsqdvaadke..ilkekkitHilnv.....atgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvv

IGYLMETYGLKYRIAYRYVQEKRFCISVNDGFASQLKVF
|.|||..  |... |...|.|.| ||. |.||. ||| .
iaylmkkeelsleealelvrearpcikPneGFikqLkey
subfamily_DSP1_pd Subfamily DSP1 2-141 2.7e-33 109.4 In-house 21-153 (163) alignment 
Range on Protein: 2-141
Range on HMM: 21-153/163.0
ILPGLYLGPYAAAqrSKLPVLLEHGITHVLCIRQApeatiIKPNFPDRFRYLVLDVADNCMENIIRHIPTVKGFIDSCLQSGGRILVHGNAGISRSAALV
||. ||||    |  |.| .| ..|||..| . .      ..  |.| |.|  | . |. ...|  .. .|  |||.. ...|..|.| .||||||..|.
ildfLylGsetva..snleiLkslgitailnvske.....ldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlc

IGYLMETYGLKYRIAYRYVQEKRFCISVNDGFASQLKVFK
. |||.|  ...  |. .|...| .|| | ||  ||. ..
laylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnye
DSPc Dual specificity phosphatase, catalytic domain 6-140 1.8e-32 107.0 Pfam-A 1-130 (133) alignment 
Range on Protein: 6-140
Range on HMM: 1-130/133.0
LYLGPYAAAQrskLPVLLEHGITHVL-CIRQAPEATIIKPNFPDRFRYLVLDvadNCMENIIRHIPTVKGFIDSCLQSGGRILVHGNAGISRSAALVIGY
|||| . .|.   |..| ..|||.|. .... |..  ||..  ...|. | |   .  ..| .... .. ||... |.|...||| .|||||||.|.| |
lylgskstas...lalleklgitlvinvtkevpnnnaikkseieylripved...etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaY

LMETYGLKYRIAYRYVQEKRFCISVNDGFASQLKVF
||.|..|... ||..|.|.| .|| |.||  ||  .
lmktknlslneAyefvkerrskispnagflrqLley
DSPc Dual specificity phosphatase, catalytic domain 6-140 1.8e-32 107.0 In-house 1-130 (133) alignment 
Range on Protein: 6-140
Range on HMM: 1-130/133.0
LYLGPYAAAQrskLPVLLEHGITHVL-CIRQAPEATIIKPNFPDRFRYLVLDvadNCMENIIRHIPTVKGFIDSCLQSGGRILVHGNAGISRSAALVIGY
|||| . .|.   |..| ..|||.|. .... |..  ||..  ...|. | |   .  ..| .... .. ||... |.|...||| .|||||||.|.| |
lylgskstas...lalleklgitlvinvtkevpnnnaikkseieylripved...etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaY

LMETYGLKYRIAYRYVQEKRFCISVNDGFASQLKVF
||.|..|... ||..|.|.| .|| |.||  ||  .
lmktknlslneAyefvkerrskispnagflrqLley
0044763 (Phosphotyrosine protein) phosphatases II 1-140 2.8e-32 107.2 In-house 25-166 (178) alignment 
Range on Protein: 1-140
Range on HMM: 25-166/178.0
EILPGLYLGPYAAAqrSKLPVLLEHGITHVLCIRQAPEATIIK--PNFPDR--FRYLVLDVADNCMENIIRHIPTVKGFIDSCL-QSGGRILVHGNAGIS
|||||||||.. .|  . |. | |.||||......  |   .|  | .|..  ..|| . . |..  ....|.. .  ||...| ..||..||| .||..
eilpglylgslppa..ddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvg

RSAALVIGYLMETYGLKYRIAYRYVQEKRFcISVNDGFASQLKVF
||..||. ||| ..|| .  |...|.|.|. |. |.|.  ||. |
RsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyef
subfamily_DSP12_pd Subfamily DSP12 1-141 4.3e-32 105.7 In-house 4-140 (155) alignment 
Range on Protein: 1-141
Range on HMM: 4-140/155.0
EILPGLYLGPYAAAQRSklPVLLEHGITHVLCIRQAPE-ATIIKPNFPDrfrYLVLDVADNCMENIIRHIPTVKGFIDSCLQSGGRILVHGNAGISRSAA
.||||||||  .|.|.   . | | .||||| . . .     .|..  .   .. ....|.  |.|..|....  ||...|. .| .||| .||.|||..
rilpglylggleavqee..ellkelkithvlsvikeelpehklkkgkvs...tkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvt

LVIGYLMETYGLKYRIAYRYVQEKRFCISVNDGFASQLKVFK
.|| ||| ...|.   |.. |.||.  |. |.|| .|||.|.
iviAYlmkkeklslekAlklvkekkpeiepNegFleQLklfe
0048076 (Phosphotyrosine protein) phosphatases II 1-140 7.1e-31 102.2 In-house 6-138 (145) alignment 
Range on Protein: 1-140
Range on HMM: 6-138/145.0
EILPGLYLGPYAAAQRskLPVLLEHGITHVLCIrqapeATIIKPNFPDRFRYLVLDVADNCMENIIRHIPTVKGFIDSCLQSGGRILVHGNAGISRSAAL
|||||||||.. .|..  |. | ..|||.||..     .. ..  ..  ..|| |.. |..  .........  ||...|..||..||| .||..|...|
eilpglylgslptald..lellkdlgittvlnl.....tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtl

VIGYLMETYGLKYRIAYRYVQEKRFCISVNDGFASQLKVF
|. ||| ..|. .  |...|...|...  |.|.  .|. |
vaaylmlllgvsleealelvrsqrpgavpnpgqlrflyef
0048179 (Phosphotyrosine protein) phosphatases II 1-140 2.4e-30 100.5 In-house 6-140 (144) alignment 
Range on Protein: 1-140
Range on HMM: 6-140/144.0
EILPGLYLGPYAAAQRskLPVLLEHGITHVLCIRQAPEATIIKPNfpdRFRYLVLDVADNCMENIIRHIPTVKGFIDSCLQSGGRILVHGNAGISRSAAL
|||||||||.. .|..  |. | ..|||.|....   | .  ...    ..|| |.. |..  ... .....  ||...|..||..||| .||..|...|
eilpglylgslptald..lellkklgittvinlteeyepeflere...giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtl

VIGYLMETYGLKYRIAYRYVQEKRFCISVNDGFASQLKVF
|. ||| ..|| .  |...|...|...  |.|.  .|. .
vaaylmkklglsleealalvrsrrpgavpnpgqlrfLley
subfamily_LRR-DSP_pd Subfamily LRR-DSP 1-140 1.3e-29 97.1 In-house 122-254 (263) alignment 
Range on Protein: 1-140
Range on HMM: 122-254/263.0
EILPGLYLGPYAAAQRSklPVLLEHGITHV-LCIRQapeatiIKPNFPDRFRYLVL-DVADNCMENIIRHIPTVKGFIDSCLQSGGrILVHGNAGISRSA
||...|.||   .|.    ..| . |.||. |.. .      ..| ||. |.||.. |. |    .| .|   .  ||..  ..|| .|||  ||.|||.
eiidklflGgldsannk..silkdlgvthillavad......fePlfPklfkylsiddiedvdeadisqhfeetnafieeGrkkGG.vlvhcraGvsrss

ALVIGYLMETYGLKYRIAYRYVQEKRFCISVNDGFASQLKVF
.||| |||    ||.. |.  |..||  |  | ||  ||| .
tlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkky
subfamily_DSP15_pd Subfamily DSP15 1-141 2.3e-28 93.2 In-house 4-136 (151) alignment 
Range on Protein: 1-141
Range on HMM: 4-136/151.0
EILPGLYLGPYAAAQRSKLpvLLEHGITHVLCIRQapeatIIKPNFPDrFRYLVLDVADNCMENIIRHIPTVKGFIDSCLQSGGRILVHGNAGISRSAAL
..||||||| .  .. ..|  | |. |||.| . .       |. ..| ..|... ..|    .. ...     || .|   .. .|||  ||.|||. |
kvlpglylgnfrdskdeel..Lkeknithilsvhd.....nakkllkd.ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtl

VIGYLMETYGLKYRIAYRYVQEKRFCISVNDGFASQLKVFK
|. |||    |..| | . ....|..   | || .|||...
vvaYlmtvtelnwrdalevikaaRsvanPnfGfkrqlkeye
0046846 (Phosphotyrosine protein) phosphatases II 2-140 8.8e-27 89.4 In-house 15-168 (176) alignment 
Range on Protein: 2-140
Range on HMM: 15-168/176.0
ILPGLYLGPYAAA--------QRSKLPVLLEHGITHVLCIRQAPEATIIK-PNFPDR-----FRYLVLDVADNCMENIiRHIPTVKGFIDSCLQSGGRIL
|...|.||.. .|          . |  |.|.|||.|... .  |   .| ||....     ..||.|.. |..  .. ......  ||...|..||..|
inanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkeggpvl

VHGNAGISRSAALVIGYLMET-YGLKYRIAYRYVQEKRF-CISVNDGFASQLKVF
||  |||.|...||. ||.|. .||..  |...|.|.|. ..  ....  .|. |
VHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyef
subfamily_DSP10_pd Subfamily DSP10 1-140 1e-26 87.7 In-house 16-149 (159) alignment 
Range on Protein: 1-140
Range on HMM: 16-149/159.0
EILPGLYLGPYAAAQRSKlpVLLEHGITHVLCIRQAPEATIIKpnfpDRFRYLVLDVADNCMENIIRHIPTVKGFIDSCLQSGGRILVHGNAGISRSAAL
..|| |.||    |.  .  .| ...||.|| . .    .  .    . ..|  ..| |.  .|. ..      ||.   ..| |.||| .|||||||..
qvlpfLflGsekdaadld..aldrlnitavlnvttsvPnefee....ealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatv

VIGYLMETYGLKYRIAYRYVQEKRFCISVNDGFASQLKVF
||.|||.  .|. . ||..|.|||  || | .|  ||. |
viaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlef
subfamily_DSP6_pd Subfamily DSP6 1-140 2.2e-26 86.2 In-house 16-150 (158) alignment 
Range on Protein: 1-140
Range on HMM: 16-150/158.0
EILPGLYLGPYAAAqrSKLPVLLEHGITHVLCIRQAPEATIIKPnfpDRFRYLVLDVADNCMENIIRHIPTVKGFIDSCLQSGGRILVHGNAGISRSAAL
|||| ||||   .|  |.| || ...| .|| . .  . .  .    . ..|| . . |. ..|. ...|    |||   ..   .|||  |||||| ..
eilpllylGsakda..snlevlkklkikyvlnvtsnlpnkfees...gelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtv

VIGYLMETYGLKYRIAYRYVQEKRFCISVNDGFASQLKVF
.. |||... |    || .|....  || |  |  ||. |
tlaylmkklalslndaydlvkkrksnisPnfnfmgqlldf
0041856 (Phosphotyrosine protein) phosphatases II 1-140 2.4e-26 87.9 In-house 21-168 (182) alignment 
Range on Protein: 1-140
Range on HMM: 21-168/182.0
EILPGLYLGPYAAAQ------------RSKLPVLLEHGITHVLCIRqapeatiIKPNFPDR-----FRYLVLDVADNCMENiirhIPTVKGFIDSCLQSG
.|...||||.. | .             . |. | |.|||......         . .|..     ..|| | . |..  .    ....  ||. .|..|
yInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.......eelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeg

GRILVHGNAGISRSAALVIGYLMETYGLKYRIAYRYVQEKRF--CISVNDGFASQLKVF
|..||| .||..|...||. |||...|. .. |...|...|.  .|. | .|  ||...
gpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlall
subfamily_Slingshot_pd Subfamily Slingshot 4-141 2.5e-26 86.1 In-house 24-154 (169) alignment 
Range on Protein: 4-141
Range on HMM: 24-154/169.0
PGLYLGPYAAAqrSKLPVLLEHGITHVLCIRQApeatiIKPNFPDRFRYLVLDVADNCMENIIRHIPTVKGFIDSCLQSGGRILVHGNAGISRSAALVIG
  .|||    |  |.|  | |.|....| . .      |.  ||..|.|| . | |.  ......  .   ||. . ..| ..|||   |.||||. || 
dhvylGsewna..snleelkengveyilnvtke.....idnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastvia

YLMETYGLKYRIAYRYVQEKRFCISVNDGFASQLKVFK
| | .|||..  |..||.|.| .|  |.|| .||....
yamkeyglsleealeyvkerrsvikPnkgflkqleeye
0043147 (Phosphotyrosine protein) phosphatases II 8-140 5.9e-26 86.6 In-house 26-156 (172) alignment 
Range on Protein: 8-140
Range on HMM: 26-156/172.0
LGPYAAAQRSKLPVLLEHGITHVLCIRqaPEATIIKPNFPDRFRYLVLDVADNCMEnIIRHIPTVKGFIDS--CLQSGGRILVHGNAGISRSAALVIGYL
.||.     . .  | |.||||....   .. .. .. ..  ..|| | . |..   ...... .  |||.  .|..||..|||  ||..|...||. ||
qgplrntladfwrmlkelgithivnlt..ellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaayl

MEtYGLKYRIAYRYVQEKRFCISVNDGFASQLKVF
|. .||..  |...|.|||.... |...  .|. |
ml.lglsleeavalvrekRpgavqnpsqyrflyyf
subfamily_DSP3_pd Subfamily DSP3 1-139 7.7e-26 84.7 In-house 13-152 (162) alignment 
Range on Protein: 1-139
Range on HMM: 13-152/162.0
EILPGLYLGPYAAAQRSKlpVLLEHGITHVLCIRQAPE-ATIIKPNFPD--RFRYLVLDVADNCMENIIRHIPTVKGFIDSCLQS-GGRILVHGNAGISR
|. |.||.|  |.|.  .   | . ||||||   ..    .  ...| .   ..|| |.| |. . .. ..  |.  |||. |..  |..||| ..|.||
evypklyvgdeavakdks..kLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsR

SAALVIGYLMETYGLKYRIAYRYVQEKRfCISVNDGFASQLKV
||.||. ||| .  ..   | | |..|| .|  |.||  ||. 
satlvlayLmirrkmtlveairtvrkkR.eilPneGFlkqLae
subfamily_DSP8_pd Subfamily DSP8 2-138 1.3e-25 83.9 In-house 18-148 (159) alignment 
Range on Protein: 2-138
Range on HMM: 18-148/159.0
ILPGLYLGPYAAAQRSKlpVLLEHGITHVLCIrqapEATIIKPNFPDRFRYLVLDVADNCMENIIRHIPTVKGFIDSCLQSGGRILVHGNAGISRSAALV
||. ||||    .  ..  .| . ||..|| .    . . .|...    ..| . | |.  |...  ...   ||| . .. ||.|||  |||||||...
ilknlylGsqkdvlsee..llsklgisyvlna....snscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatva

IGYLMETYGLKYRIAYRYVQEKRFCISVNDGFASQLK
|.|.| |  ...  |||.|.|||  || |  |  || 
iayimktlemsldeayrfvkekrptispnlnflgqLl
0049260 (Phosphotyrosine protein) phosphatases II 8-139 1.1e-24 82.3 In-house 15-144 (152) alignment 
Range on Protein: 8-139
Range on HMM: 15-144/152.0
LGPYAAAQRSKLPVLLEHGITHVLCIRQAPEatIIKPNFPDRFRYLVLDVADNCMENIIRHIPTVKGFIDS-CLQSGGRILVHGNAGISRSAALVIGYLM
.||.     . .  | |.|||..... .  |  . |. ..  ..|| | . |..  ... ... .  ||.  .|..||..|||  ||..|...||. |||
qgpgpntladfwrmlkelgittivmltelle..lgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylm

EtYGLKYRIAYRYVQEKRFCISVNDGFASQLKV
. .|...  |...|.||| ..  | |.  .|. 
l.lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_DSP14_pd Subfamily DSP14 1-140 1.4e-24 80.9 In-house 9-140 (157) alignment 
Range on Protein: 1-140
Range on HMM: 9-140/157.0
EILPGLYLGPYAAAQRSKlpvLLEHGITHVLCIRQapeaTIIKPNFPDrFRYLVLDVADNCMENIIRHIPTVKGFIDSCLQSGGRILVHGNAGISRSAAL
.| | |.|. .|| ....   | ...||... . .     . .....| .... . |.||  ... .|  .|   |..  ..||..|||  ||.||||.|
qitpsLflsgvaalskel...lkkkkitliinvtv....elpntklkd.iervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAsl

VIGYLMETYGLKYRIAYRYVQEKRFCISVNDGFASQLKVF
.. |||..  |  | ||..|...|  |. | || .||  .
claylmkyeklsLreayklvksaRpiirPNvGFwkqlidy
0049772 (Phosphotyrosine protein) phosphatases II 40-141 4.6e-24 81.1 In-house 168-270 (314) alignment 
Range on Protein: 40-141
Range on HMM: 168-270/314.0
TII--KPNFPDR-FRYLVLDVADnCMENIIRHIPTVKGFIDSClQSGGRILVHGNAGISRSA-ALVIGYLMETYGLKYRIAYRYVQEKRFcISVNDGFAS
...  .. |... ..|| ..| |   ........ .  ||... . ||..||| .||..|.. ..|..|||  .|. .. |...|..||. |. |.||  
eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfie

QLKVFK
||. . 
qleqye
subfamily_MKPLT_pd Subfamily MKPLT 6-141 1.7e-23 76.9 In-house 29-157 (164) alignment 
Range on Protein: 6-141
Range on HMM: 29-157/164.0
LYLGPYAAAQRSKlpVLLEHGITHVLCIRQApeatiIKPNFPDRFRYLVLDVADNCMENIIRHIPTVKGFIDSCLQSGGRILVHGNAGISRSAALVIGYL
||||    |.  |  || .  |||.. . |       | .||  . || ..| |.  |... ..  .. |. . ..||||.||| . | |||..  . .|
lylGnakhatnek..vlkdlkithivnvsqe.....kkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafL

METYGLKYRIAYRYVQEKRFCISVNDGFASQLKVFK
..  |  .. || |..|.| ... | ||  ||  |.
ikskgwtlkeayeylkerrsivapnrGflkqlakfe
subfamily_MKPLV_pd Subfamily MKPLV 6-141 1.7e-23 76.9 In-house 29-157 (164) alignment 
Range on Protein: 6-141
Range on HMM: 29-157/164.0
LYLGPYAAAQRSKlpVLLEHGITHVLCIRQApeatiIKPNFPDRFRYLVLDVADNCMENIIRHIPTVKGFIDSCLQSGGRILVHGNAGISRSAALVIGYL
||||    |.  |  || .  |||.. . |       | .||  . || ..| |.  |... ..  .. |. . ..||||.||| . | |||..  . .|
lylGnakhatnek..vlkdlkithivnvsqe.....kkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafL

METYGLKYRIAYRYVQEKRFCISVNDGFASQLKVFK
..  |  .. || |..|.| ... | ||  ||  |.
ikskgwtlkeayeylkerrsivapnrGflkqlakfe
0040439 (Phosphotyrosine protein) phosphatases II 2-140 3.2e-22 74.8 In-house 32-241 (249) alignment 
Range on Protein: 2-140
Range on HMM: 32-241/249.0
ILPGLYLGPYAAAQRSKLP----------------------VLLEHGITHVLCIRQAPEATIIKP-----------------------------------
|||||.|. |  |   ...                       | |.|||.......  |   .|                                    
ilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtlel

---NFPDRFRYLVLDVADNCMENIIRHIPTVKGFIDSCLQ------SGGRILVHGNAGISRSAALVIGYLM-----ETYGLKYRIAYRYVQEKRFCISVN
    ... ...|.. . |    ..  .....  ||. ...      .||..||| .||..|...... |||     ...|. .  |.......|...  |
tnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqn

DGFASQLKVF
...  .|  .
peqyrflyea
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 7-141 7.8e-22 71.3 In-house 11-149 (154) alignment 
Range on Protein: 7-141
Range on HMM: 11-149/154.0
YLGPYAAAQrSKLpVLLEHGITHVLCIRQAPEATIIKP--NFPD--RFRYLVLDVADNCMENIIRHIPTVKGFIDSCL--QSGGRILVHGNAGISRSAAL
|.. . ||   ||  | .. |...| .    .    .   .  |   . || |.. |.   .||...  .  |||. .     ...||| ..|.||||||
yissfdaal.nkl.dlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaal

VIGYLMETYGLKYRIAYRYVQEKRFCISVNDGFASQLKVFK
.|.|||.   . .  |.  ... |. |. | ||  ||..|.
lisylmdklkislslalellkdsryiikPnqGflkqleife
0045098 (Phosphotyrosine protein) phosphatases II 5-140 9.5e-22 73.1 In-house 28-267 (278) alignment 
Range on Protein: 5-140
Range on HMM: 28-267/278.0
GLYLGPYA---------------------------------------AAQRSKLPVLLEHGITHVLCIRQAPEA--------------------------
.||||...                                           . .  | |.|||..... .  |                           
alylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtlls

---------------------TIIKPNFPDRFRYLVLDVADNCMENIIRHIPTVKGFIDSCLQ--------------SGGRILVHGNAGISRSAALVIGY
                     . .....   . ||  .  .   ..|....  .  ||...|.              |||..||| .||..|...||. |
eevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaay

LMETY---GLKYRIAYRYVQEKRFC-ISVNDGFASQLKVF
|| ..   |. .  |.......| . .  | ..  .|  |
lmlelleggvdlleavkelrsqRpglavqnleqyrflyef
0036282 (Phosphotyrosine protein) phosphatases II 2-139 3e-21 71.3 In-house 15-164 (174) alignment 
Range on Protein: 2-139
Range on HMM: 15-164/174.0
ILPGLYLGPYAAAqrsKLPVLLEHGITHVLCIRQAPEAT----------IIKPNFPDRFRYLVLDVADNCMENIIRhIPTVKGFIDSCLQS--GGRILVH
|.|.|..| . .|    .. | |.|||.|.. ..  |              .   .  ..|| | . |... ..   . ..  |....|..  || .|||
itprliagqgpla...fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVH

GNAGISRSAALVIGYLMETYGL-KYRIAYRYVQEKR---FCISVNDGFASQLKV
 .||..|...||. |||....| ... |...|.|.|    ..  ....  .|  
CsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyy
0045450 (Phosphotyrosine protein) phosphatases II 21-138 1.3e-20 69.8 In-house 126-297 (307) alignment 
Range on Protein: 21-138
Range on HMM: 126-297/307.0
VLLEHGITHVLCIRQAPEA-----------------------TIIKPNFPDRFRYLVLDVADN-----------------CMENIIRHIPTVKGFIDSCL
 | |.|.|.......  |                        | .. .  | . ...| | |.                    ..  .. ..  ||. ..
mlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevr

Q------SGGRILVHGNAGISRSAALVIGYLMETYG--------LKYRIAYRYVQEKRFCISVNDGFASQLK
.      .||..||| .||..|...... ||| ...        . .. |.....|.| ..  | ..  .| 
kaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrfly
0037934 (Phosphotyrosine protein) phosphatases II 16-139 3.1e-20 68.2 In-house 62-236 (243) alignment 
Range on Protein: 16-139
Range on HMM: 62-236/243.0
RSKLPVLLEHGITHVLCIRQAPEATII----------------------------------------KPNFPDRFRYLVLDVAD----NCMENIIRHIPT
 | .  | |.|||.......  | . .                                        .. .   ..|. | . |    . .|......  
asfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldflde

VKGFIDS-----CLQSGGRILVHGNAGISRSAALVIGYLMETY-GLKYRIAYRYVQEKRFC-ISVNDGFASQLKV
|. ||..     .| |||..|||  ||..|...|.. ||| .. |. .  |.....|.|.. .  . ..  .|  
vrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflye
0051082 (Phosphotyrosine protein) phosphatases II 2-139 5.7e-20 66.9 In-house 11-148 (151) alignment 
Range on Protein: 2-139
Range on HMM: 11-148/151.0
ILPGLYLGPYAAAqrSKLPVLLEHGITHVLCIRQAPEATIIKPNFPD-RFRYLVLDVADNCMENIIRHIPTVKGFIDSCLQS-GGRILVHGNAGISRSAA
. .|||.. .  |    |. | |.||......|. .|    .  .|.  ...| . . |..  ..  ....|. |.. .|.  .| .||| .||..|...
vtgglyrsggpla..dflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGt

LVIGYLMEtYGLKYRIAYRYVQEKRF-CISVNDGFASQLKV
||. |||  .|. .  |......||. ..  |..|  ||..
lvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfa
0042113 (Phosphotyrosine protein) phosphatases II 4-139 1.5e-19 65.8 In-house 52-237 (245) alignment 
Range on Protein: 4-139
Range on HMM: 52-237/245.0
PGLYLGPYAAAQrsKLP----VLLEHGITHVLCIRQAPEATI-----------------------------------------IKPNFPDRFRYLVLDVA
|..... . ...   ..     | |.|||.......  |                                             ..     ..|. |.. 
pkfiatqgPlpe..tvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwp

DNCMENIIRHIPTVKGFIDSCLQ--SGGRILVHGNAGISRSAALVIGYLM-----ETYGLKYRIAYRYVQEKRFCISVNDGFASQLKV
|... ......  .  |....|.  |.|..||| .||..|...... |||     ...|.    |.......| ..  ....  .|  
dhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflye
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 6-138 2.8e-19 63.1 In-house 15-141 (148) alignment 
Range on Protein: 6-138
Range on HMM: 15-141/148.0
LYLGPYAaaQRSKLPVLLEHGITHVLCIRQaPEATIIKPNfpdRFRYLVLDVADNCMENIIRHIPTVKGFIDSCLQSGGRILVHGNAGISRSAALVIGYL
|.||     . ..| .| . |.|..    .     ..        .|| . ..|.  |..    ...  |..   . |.|.||| . |.|||.||.. .|
LFlGskk..saadlealkalgvtrivnatk.erdnaldqr...gieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwl

METYGLKYRIAYRYVQEKRFCISVNDGFASQLK
...     . |. .|..||  .  | || .|| 
idfkrvslkealalvkskrryvdpnlgfLkqLa
subfamily_STYXL1_pd Subfamily STYXL1 1-139 5.8e-19 61.8 In-house 13-148 (157) alignment 
Range on Protein: 1-139
Range on HMM: 13-148/157.0
EILPG-LYLGPYAAAQRSKLPVLLEhgITHVLCIRQapEATIIKPNFPDRFRYLVLDVADNCMENIIRHIPTVKGFIDSCLQSGGRILVHGNAGISRSAA
|.||| |||| |  ||  ..   |   .  .. . .  .|  .    .|  . | ..| |.   ... ..  .  ||..  ..|  .|| .| |||||||
evlPgklylGnykqaqnpaikkdlk..vkahvnvsm..dadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaa

LVIGYLMETYGLKYRIAYRYVQEKRFCISVNDGFASQLKV
..|.|||  . .... || |... .  .  | .| .||. 
viiaylmyskkitlkkaykylkkCkenvkPnrafveqlse
0040438 (Phosphotyrosine protein) phosphatases II 21-139 1.4e-17 59.4 In-house 105-270 (317) alignment 
Range on Protein: 21-139
Range on HMM: 105-270/317.0
VLLEHGITHVLCIRQAPEA----------------------TIIKPNFPDRFRYLVLDVADN----------------CMENIIRHIPTVKGFIDSCLQS
 . |.|.|..... .  |                       |...    . . ...| | |.                   ..  .. ..  |.. . ..
mvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrea

----GGRILVHGNAGISRSAALVIGYLM-----ETYGLKYRIAYRYVQEKRFCISVNDGFASQLKV
    || .||| .||..|...... |||     ...|. .  |.....|.| ..  . ..  .|  
ledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyd
0039614 (Phosphotyrosine protein) phosphatases II 21-138 1.5e-17 59.5 In-house 120-282 (297) alignment 
Range on Protein: 21-138
Range on HMM: 120-282/297.0
VLLEHGITHVLCIRQAPEA--------------------TIIKPNFPDRFR-----------------YLVLDVADNCMENIIRHIPTVKGFIDSCLQ--
 . |.|.|..... .  |                     | .|    | .                  .....  |..  ......  .  .....|.  
mvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealael

-SGGRILVHGNAGISRSAALVIGYLM-----ETYGLKYRIAYRYVQEKRFCISVNDGFASQLK
 .||..||| .||..|...... |||     ...|. .  |.....|.| ..  ....  .| 
pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrfly
0051429 (Phosphotyrosine protein) phosphatases II 17-138 2e-17 59.2 In-house 36-218 (272) alignment 
Range on Protein: 17-138
Range on HMM: 36-218/272.0
SKLPVLLEHGITHVLCIRQAPEATIIK-PNFPDRFRYLVLDVADNCMENIIRHI----------------------------------------------
  .. | |.||......|.  |    | . ..  .|||.|.. |.. . |  .                                               
adfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgv

--PTVKGFIDSCLQsGGRILVHGNAGISRSAALVIGYLMEtYGLK--------------YRIAYRYVQEKRFCISVNDGFASQLK
   ... ... .|. ||..||| .||..|.. .|  .|.  .|.               .. |.......| ..  ....  .| 
pqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylfly
PTEN_1 2-137 3.8e-17 57.7 In-house 44-184 (196) alignment 
Range on Protein: 2-137
Range on HMM: 44-184/196.0
ILPGLYLGPYAAAQRsKLPVLLEHGITHVLCIRQAPEA----TIIKPNFPDRFRYLVLDVADNCMENIIRHIPTVKGFIDSCLQ--SGGRILVHGNAGIS
| .|||.|..  ...  |  | |.|||.|..    .|        .  |  ...|| ... |    .. ...  .| ||...|.  .|. .|||  ||..
ideglyrgslkdvaa.dldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlg

RSAALVIGYLMETYGLKYRIAYRYVQEKRFCISVNDGFASQL
||. .|. |||....| .. | ..|.||| ....| ..  .|
RsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerl
0036941 (Phosphotyrosine protein) phosphatases II 2-138 1e-15 53.3 In-house 22-270 (297) alignment 
Range on Protein: 2-138
Range on HMM: 22-270/297.0
ILPGLYLGPYAAAQRSKLP--------------------------------------------------------VLLEHGITHVLCIRQAPEATIIK--
.|| |.||.. .|.. .                                                           ..|...|..... .  |   .|  
llpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekca

---PNF---------------------PDRFRYLVLDVAD----------------NCMENIIRHIPTVKGFIDSCLQ------SGGRILVHGNAGISRS
   |.                       | . . .| | |                    ..  .. ..  ||. ...      |||..||| .||..||
qywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRs

AALVIGYLM--------ETYGLKYRIAYRYVQEKRFCISVNDGFASQLK
..... .||        ...|. .  |.... |.|...  . ..  .| 
gtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrfly
0043336 (Phosphotyrosine protein) phosphatases II 21-138 1.1e-14 50.0 In-house 107-270 (278) alignment 
Range on Protein: 21-138
Range on HMM: 107-270/278.0
VLLEHGITHVLCIRQAPEATI----------------------------------------IKPNFPDRFRYLVLDVADNCME-NIIRHIPTVKGFIDSC
 . |.|.|.......  |                                            ...     .|  |.. |..   ..  ..  .| ... .
mvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreal

LQSGGRILVHGNAGISRSAALVIGYLM-----ETYGLKYRIAYRYVQEKRFCISVNDGFASQLK
  |.| .||| .||..|...... ||.      ..|. .  |.....|.|...  .. .  .| 
edsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrfly
0038934 (Phosphotyrosine protein) phosphatases II 62-140 9.6e-13 43.7 In-house 96-172 (194) alignment 
Range on Protein: 62-140
Range on HMM: 96-172/194.0
MENIIRHIPTVKGFIDSclQSGGRILVHGNAGISRSAALVIGYLMETYGLKYRIAYRYVQEKRFCISVNDGFASQLKVF
.|.. | .  |. |..   ..|| ..||  ||..|.. ||. ||....|.... |.....|||  .  | .. ..| ..
leillrfldlvdeflne..dpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkr
subfamily_PTPMT1_pd Subfamily PTPMT1 53-140 1.2e-12 42.6 In-house 77-164 (171) alignment 
Range on Protein: 53-140
Range on HMM: 77-164/171.0
LVLDVADNCMENIIRHIPTVKGFIDSCLQSGGRILVHGNAGISRSAALVIGYLMETYGLKYRIAYRYVQEKRFCISVNDGFASQLKVF
| | . |   .  . ..     ||..  ..| |. || .|| .|||.||. ||| .. |.   | .....||  | ...   ..|. .
lqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqey
subfamily_MSG5_pd Subfamily MSG5 63-138 2.9e-12 40.0 In-house 79-154 (165) alignment 
Range on Protein: 63-138
Range on HMM: 79-154/165.0
ENIIRHIPTVKGFIDSCLQSGGRILVHGNAGISRSAALVIGYLMETYGLKYRIAYRYVQEKRFCISVNDGFASQLK
 .|.. ....   | .    . .|||| . |.||||.|.. |.|  |.|  | ||  .. .   || . |.  || 
skivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlm
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 14-135 2e-11 37.2 In-house 12-132 (145) alignment 
Range on Protein: 14-135
Range on HMM: 12-132/145.0
AQRSKLPVLLEHGITHVLCIRqAPEATIIKPNFPDRFRYLVLDVADNCMENIIRHIPTVKGFIDSCLQSGGRILVHGNAGISRSAALVIGYLMETYGLKY
 . ...|.| | ||. .. .  | ..   .    . .  |..   |    .. .|.  |  |||   . |  ..||  ||.||| .. . .||   ..  
lhandvptlqelgisrivnma.agslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkycnmtl

RIAYRYVQEKRFCISVNDGFAS
  | | |. .|.    |  |  
seaarqvrsnrllaypnvtflk
subfamily_Laforin_pd Subfamily Laforin 40-127 1.2e-10 34.6 In-house 67-154 (183) alignment 
Range on Protein: 40-127
Range on HMM: 67-154/183.0
TIIKPNFPDRFRYLVLDVADNCMENIIRHIPTVKGFIDSCLQSGGRILVHGNAGISRSAALVIGYLMETYGLKYRIAYRYVQEKRFCI
|..|    . . |. | . |   |. .. .|    .. . |. | .. || |||. ||.|.| |.|.   | . .    ..  || ..
tlkklykeeglayiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvv
0047943 (Phosphotyrosine protein) phosphatases II 24-132 1.8e-10 36.2 In-house 99-259 (273) alignment 
Range on Protein: 24-132
Range on HMM: 99-259/273.0
EHGITHVLCIRQAPEATIIKPN--FPDRF------------------------------------------RYLVLDVADNCMENIIRHIPTVKGFIDSC
|...... .. .  |   .|    .|.                                             .....  |..    . .. .   .....
eqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrka

LQ---SGGRILVHGNAGISRSAALVIGYLM-----ETYGLKYRIAYRYVQEKRFCISVNDG
|.   |.| ..|| .||..|...... .|.     ...|. .  |.......|...  .  
lealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpe
0051299 (Phosphotyrosine protein) phosphatases II 24-128 1.5e-09 33.2 In-house 114-269 (288) alignment 
Range on Protein: 24-128
Range on HMM: 114-269/288.0
EHGITHVLCIRQAPEATI---------------------------------------------IKPNFPDRFRYLVLDVADNCMEN-IIRHIPTVKGFID
|...... .. .  |                                                 . .      . ...  |... . .   .  .. ...
eqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrk

SCLQSGGRILVHGNAGISRSAALVIGYLM-----ETYGLKYRIAYRYVQEKRFCIS
.. ..|| ..|| .||..|...... .|.     ...|. .  |.... |.|... 
alasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmv
0046845 (Phosphotyrosine protein) phosphatases II 62-126 1.9e-08 29.5 In-house 184-255 (284) alignment 
Range on Protein: 62-126
Range on HMM: 184-255/284.0
MENIIRHIPTVKGFIDScLQSGGRILVHGNAGISRSAALVIGYLMETY--------GLKYRIAYRYVQEKRFC
.|.... . .|. .... | .|| |.||  ||..|...... .|. ..        |. .  |.... |.|..
pedlleflrlvrellen.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpg
0050432 (Phosphotyrosine protein) phosphatases II 69-126 2.5e-08 29.1 In-house 216-280 (308) alignment 
Range on Protein: 69-126
Range on HMM: 216-280/308.0
IPTVKGFIDSCLQ--SGGRILVHGNAGISRSAALVIGYLM-----ETYGLKYRIAYRYVQEKRFC
.  .  |.. . .  .|| |.|| .||..|...... .|.     ...|. .  |.... |.| .
peilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpg
subfamily_CDC14_pd Subfamily CDC14 72-114 1.2e-06 22.6 In-house 252-294 (328) alignment 
Range on Protein: 72-114
Range on HMM: 252-294/328.0
VKGFIDSCLQSGGRILVHGNAGISRSAALVIGYLMETYGLKYR
|| |.. . .. | | ||  ||. |  .|.  |||..|..   
vkkfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaa
DAGAT Diacylglycerol acyltransferase 25-110 3.1e-06 12.3 Pfam-A 72-155 (297) alignment 
Range on Protein: 25-110
Range on HMM: 72-155/297.0
HGITHVLC-IRQAPEATIIKPNFPdRFRYLVLDVADNCMENIIRHIPTVKGFIDSCLQSGGRILVHGNAGisRSAALVIGYLMETYG
|||  |   .  | .|| .|. || . |. .  .| . .  . |.| .. |.|..  .|   .| ... |  |. .||.|   |.. 
hgilsvgafvalatdatgvkekfp.girfnlatLagqfrtpfrreillllGlievsresieyvLdkeekG..ravvlvvGGaeeale
0048567 (Phosphotyrosine protein) phosphatases II 64-124 5.5e-06 20.8 In-house 55-118 (157) alignment 
Range on Protein: 64-124
Range on HMM: 55-118/157.0
NIIRHIPTVKGFIDSCLQSGGRILVHGNAGI---SRSAALVIGYLMETYGLKYRIAYRYVQEKR
 ..| |  .. |....   |..| ||  ||    .|.| |.  ||.  .|.  . |.....  |
ilyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivr