Gene MTMR14 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Myotubularin
Subfamily MTMR14
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP032_AA protein Get Run
SpurP032_AA_232-393 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_MTMR14_pd Subfamily MTMR14 41-397 7e-179 586.2 In-house 1-355 (357) alignment 
Range on Protein: 41-397
Range on HMM: 1-355/357.0
RKCLALFAKDYKYSVILNSNGELCGHYPGKLVILEYMLGaDGQVGERDHVESMYDVTKLREIMCRSRFARCRERFVMPVILCDGKHICRSATLSGGPEIY
.|...|...||..||| |.|||||..||.||.||||.|| .|. ||...|||.|||..|||.......||||||||.||||.|||.||||||||  .|||
kkveellkrdyslsvidntnGelcsrypvkllileyelg.egsegekelvesaydvqrlrelltkakyarcrerfvvpvilldgknicrsatlsvaaeiy

GRSGFNYLFSGGESAELD--DEETMTSLSRspstSSNDWPLFDRYRGQDIKLLKMLQVTAVCDLMLENKKVKFGVNVTSSEKVDKEHRYADFCLLSLPYP
||||.|||.||||.|. |  |||..|. ..    ..... |.||.|..||||||.|.|....|||.|.||||.|..|.||||.|||.||.||.|||||||
grsGlnylasggeeadadkedeelitaked....qaeeqalldrvrksdikllktlkvklivdlmvekkkvkyglavsssekadkekrykdftllslPyP

GCEFFKDFRDNGFNGINLFFDWSQDFVDADLSIPDRVATSTGIDWHMYRQWDLVKITQNYLKLLLFLIK-DGDSGVLVHCISGWDRTPLFISLLRLSLWA
|.||||.|||| ..  |||..|.||.|||.|.|||..|.|..|||..|..||||..||||||||| ..| |.|||.||||||||||||||.|||||||||
GveffkkfrdnkysaknlfynWkqdevdaelniPdklaasvdidwseykkWdlvaltqnylklllkyvkededsGllvhcisGWdrtPlfvsllrlslWa

DCKAHANLSAAEILYLTIAYDWLLYGHNLCDRLGKGEDVFFFCFNFLKHITSDDFSLLQR
|.. |..|||||.||||.||||.|.||.|.||| |||...||||..||.|||..||.|. 
dglihqslsaaellyltvaydWflfghqlpdrlkkgeeilffcfdvlkfitseefsilet
0040695 (Phosphotyrosine protein) phosphatases II 40-395 3.7e-48 158.2 In-house 14-318 (388) alignment 
Range on Protein: 40-395
Range on HMM: 14-318/388.0
ERKCLAL-FAKDYKYSVILNSNGELCGHYPGKLVileymlgadgqvgerdhvesmydVTKLREIMCRSRFARCRERFVMPVILC----DGKHICRSATLS
.|..  | .  |. . .|.|.|.|||..||..||                       | |  .  .  |.||.|... .||..     .|....||... 
lrelkrlglgldlwrisivNenyelcpsYPallv.......................VPksisdellkrvarfrskgriPvlsyrhpnngavllRssqpl

GgpeiygrsgfnylfsggesaelddeetmtslsrspSTSSNDWPLFDRYRGQDIKLLKMLQVTAVCDLMlenKKVKFGVNVTSSEKVDKEHRYADFCLLS
.                                   ... ...  .........|||. |..  ..||.   .|... .|......|..|..|... |..
v...................................glllsrsledeklleailkllpnlskllivdlr...pklnalanralgggvenedaypnaelif

LPYPGCEFFKDfrdngfnginlffdWSQDFVDADLSIPDRVatSTGIDWHMYRQWDLVKITQNYLKLLLFLIKDGDSGVLVHCISGWDRTPLFISLLRLS
|..|.......              . |...|| |..||    .  . .. .. .||.|.......|.. |...|.|.|||||..|||||....||..|.
lnipnihvvre..............slqklldaclnvpdsl..nllslleesgwldliklilelavlivklldlgnssvlvhcsdgwdrtsqlssLaqll

LWADckaHANLSAAEILyltIAYDWLLYGHNLCDRLGKGED---------------------------VFFFCFNFLKHITSDDFSLL
|...   .  |    .|   |...||..|| ..|||| .|.                           .|.|....|....   .| .
ldPy...YRTleGFqvL...iekeWlsfghkfadRlghleseidskefsPvFllFLdcvwqLlrqfPtaFeFnerlLlfLadhlyscr
subfamily_MTMR3_pd Subfamily MTMR3 309-376 7.8e-10 31.1 In-house 268-329 (442) alignment 
Range on Protein: 309-376
Range on HMM: 268-329/442.0
GDSGVLVHCISGWDRTPLFISLLRLSLwaDcKAHANLSAAEILyltIAYDWLLYGHNLCDRLGKGEDV
    |||||  |||||.  ..| .| |  | . .  |   ..|   .  .|| .|| . || | ||.|
egrpvlvhCsdGWdrttqivalaklll..d.pyyrtleGfkvl...vereWldfGhkfadrcghgenv
0051429 (Phosphotyrosine protein) phosphatases II 263-340 1.2e-09 33.7 In-house 102-180 (272) alignment 
Range on Protein: 263-340
Range on HMM: 102-180/272.0
DFVDADLSIPD--RVATSTGIDWHMYRQWDLVKITQNYLKLLLFLIKDgDSGVLVHCISGWDRTPLFISLLRLSLWADCK
|..   | .       ..  . . .|..|    . |..|. || |. | .  ||||| .|.||| ... ||.| |  .  
dyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvallllllgvsle
subfamily_MTMR1_pd Subfamily MTMR1 306-375 2.6e-09 28.9 In-house 208-271 (389) alignment 
Range on Protein: 306-375
Range on HMM: 208-271/389.0
IKDGDSGVLVHCISGWDRTPLFISLLRLSLwaDCkAHANLSAAEILyltIAYDWLLYGHNLCDRLGKGED
..   . |||||  |||||  ..||  | |  |   .  ..  |.|   |. .|| .||.. .|||.|..
vetektsvlvhcsdGWDRtaqltsLamlll..Ds.yyRtieGfevl...iekeWlsfGHkfkeRlghgdk
0051082 (Phosphotyrosine protein) phosphatases II 205-334 7.3e-09 30.9 In-house 30-116 (151) alignment 
Range on Protein: 205-334
Range on HMM: 30-116/151.0
ENKKVKFGVNVTSSEKVDKEHRYAD---FCLLSLPYPGCEFFKdfrdngfnginlffdwsqdfvdadlsipdrvatstgidwhmyrqwdLVKITQNYLKL
.. ..|  ||..| |  .....|     . .| .|...  ...                                              |  ... .|..
kelgiktivnlrseeergycpeylpelgievlhipildwpdpg..............................................lplsfdavlef

LLFLIKDGDSGVLVHCISGWDRTPLFISLLRLS
| .|.....  ||||| .|..|| ... |... 
lellldkkngpvlvHCsaGkgRTGtlvalylml
Myotub-related Myotubularin-like phosphatase domain 302-373 2.8e-08 25.9 Pfam-A 223-288 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 302-373 2.8e-08 25.9 In-house 223-288 (353) alignment
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 302-385 4.5e-08 24.6 In-house 214-279 (404) alignment 
Range on Protein: 302-385
Range on HMM: 214-279/404.0
LLFLIKDGDSGVLVHCISGWDRTPLFISLLRLslWADCkAHANLSAAEILyltIAYDWLLYGHNLCDRLGKgedvfffcfnflK
.. ||..  | |||||. |||||.   || .|   .|   . .... ..|   |  .|| .||   .| |.            .
iveliekekssvlvhcsdgwDrtsqlsslsql..lldp.yyrtiegFivl...iekewlsfGhkfaqRigq............t
0044763 (Phosphotyrosine protein) phosphatases II 186-331 5e-08 28.3 In-house 39-131 (178) alignment 
Range on Protein: 186-331
Range on HMM: 39-131/178.0
QDIKLLKMLQVTAVCDLMLENKKVKFGVNVTSSEKVDkehryadfcllslpypgceffkdfrdngfnginlffdwsqdfvdadlsipdrvatstgIDWHM
.|..||| | .|....|  |    ... .    |. .                                                          | .. 
ddlellkelgithivnlteelelgflkcdpywpeeag..........................................................iqylh

Y-----RQWDLVKITQNYLKLLLFLIKDGDSGVLVHCISGWDRTPLFISLL
.        || ..... ....  .... .. |||||  |..|..... . 
ipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaay
0049772 (Phosphotyrosine protein) phosphatases II 273-336 1.1e-07 27.4 In-house 173-240 (314) alignment 
Range on Protein: 273-336
Range on HMM: 173-240/314.0
DRVATSTGIDWHMYRQWDLVKITQNYLKLLLFLIKD--GDSGVLVHCISGWDRTP--LFISLLRLSLW
.   . .|| .. .  .|    . .... .| .|..   .. ||||| .|..||.  ... .| . |.
pelferlgikylripvpDgsaplledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkllg
subfamily_MTMR6_pd Subfamily MTMR6 306-372 3.1e-07 22.0 In-house 219-279 (397) alignment 
Range on Protein: 306-372
Range on HMM: 219-279/397.0
IKDGDSGVLVHCISGWDRTPLFISLLRLSLwaDcKAHANLSAAEILyltIAYDWLLYGHNLCDRLGK
... .  |||||  |||||   .||  | |  | . .  .    .|   |  .|| .|| . .| |.
vaeegasvlvhcsdGwdrtaqvcslaslll..d.pyyrtikGflvl...iekewlsfGhkfsercGl
0043147 (Phosphotyrosine protein) phosphatases II 185-333 3.9e-07 25.5 In-house 34-123 (172) alignment 
Range on Protein: 185-333
Range on HMM: 34-123/172.0
GQDIKLLKMLQVTAVCDLMlENkkvkfgvnvtssekvdkehryadfcllslpypgceffkdfrdngfnginlffdwsqdfvdadlSIPDRVATSTGIDWH
 .....|| |..|.. .|. |                                                                  .    . .|| ..
adfwrmlkelgithivnlt.el...............................................................lydpellerlgiqyl

MYRQWDLVKITQNYLKLLLFLIKD-----GDSGVLVHCISGWDRTPLFISLLRL
 .   |    . ..|  .| .|..      .  |||||  |..||.... .. .
ylpwpDhgvpllellleflefidellalspggpvlVHCsaGvgRtgtlvaaylm
subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 305-372 5.4e-07 20.7 In-house 229-289 (405) alignment 
Range on Protein: 305-372
Range on HMM: 229-289/405.0
LIKDGDSgVLVHCISGWDRTPLFISLLRLSLWADCKAhanLSAAEILyltIAYDWLLYGHNLCDRLGK
||  |.| .||||  ||||||   || .. |    ..   .   ..|   |  .|| .||..  |||.
lilkgns.ilvhcsdgwdrtpqitsltqilldpyyrt...ivgfqvl...iekewlsfghkfslrlgh
0048179 (Phosphotyrosine protein) phosphatases II 186-334 7.4e-07 24.5 In-house 20-107 (144) alignment 
Range on Protein: 186-334
Range on HMM: 20-107/144.0
QDIKLLKMLQVTAVCDLMLENKKVKFGVNvtssekvdkehryadfcllslpypgceffkdfrdngfnginlffdwsqdfvdadlsipdrvatstGIDWHM
.|..||| |..|.|..|. |  .  ....                                                                 || .. 
ldlellkklgittvinlteeyepeflere.................................................................giqylh

YRQWDLVKITQ-NYLKLLLFLIKDG---DSGVLVHCISGWDRTPLFISLLRLS
.   |    .  ..|  .| .|..    .  |||||  | .||.... . .. 
lpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk
0049260 (Phosphotyrosine protein) phosphatases II 230-333 9.5e-07 24.1 In-house 55-112 (152) alignment 
Range on Protein: 230-333
Range on HMM: 55-112/152.0
FcllslpypgceffkdfrdngfnginlffdwsqdfvdadlsipdrvaTSTGIDWHMYRQWDLVKITQNYLKLLLFLIKDGDSGVLVHCISGWDRTPLFIS
.                                              .   . |  .  .||  . .  |... .|..| .  |||||  | .||.... 
i..............................................qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlva

LLRL
.. .
aylm
0048076 (Phosphotyrosine protein) phosphatases II 274-334 2.5e-06 22.8 In-house 41-105 (145) alignment 
Range on Protein: 274-334
Range on HMM: 41-105/145.0
RVATSTGIDWHMYRQWDLV-----KITQNYLKLLLFLIKDGdSGVLVHCISGWDRTPLFISLLRLS
.  . .|| .. .  .|       .. .. |...  ..|.|   |||||  | .||.... .  . 
ellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylml
0043336 (Phosphotyrosine protein) phosphatases II 282-334 2.7e-06 22.5 In-house 182-234 (278) alignment 
Range on Protein: 282-334
Range on HMM: 182-234/278.0
DWHMYRQWDLVKITQNYLKLLLFLIKDGDSGVLVHCISGWDRTPLFISLLRLS
.|  .   . ... ...|| ..  ..| .. |||||  | .|| .|| |..| 
gwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialylll
0042113 (Phosphotyrosine protein) phosphatases II 282-336 2.8e-06 22.4 In-house 147-202 (245) alignment 
Range on Protein: 282-336
Range on HMM: 147-202/245.0
DWHMYRQWDLVKITQNYLKLLLFLIK-DGDSGVLVHCISGWDRTPLFISLLRLSLW
.|  .   ||... .. |....  .. |..  |||||  | .|| .|| ....  .
pwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleq
0045098 (Phosphotyrosine protein) phosphatases II 276-336 3.3e-06 22.2 In-house 151-232 (278) alignment 
Range on Protein: 276-336
Range on HMM: 151-232/278.0
ATSTGIDWHMYRQWD--------LVKITQNYLKLLLFLIK-------------DGDSGVLVHCISGWDRTPLFISLLRLSLW
 .| |. .. |  |.        ..|  ...|. ..  .|             |..  |||||  |..||  .. .  .   
lesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlel
0040439 (Phosphotyrosine protein) phosphatases II 282-334 3.8e-06 22.2 In-house 149-203 (249) alignment 
Range on Protein: 282-334
Range on HMM: 149-203/249.0
DWHMYRQWDLVKITQNYLKLLLFLIK--DGDSGVLVHCISGWDRTPLFISLLRLS
||. .   . .... .......  ..  . .. |||||  | .||..|| .. . 
dwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylml
Resistin Resistin 404-452 5.9e-06 13.1 Pfam-A 22-70 (89) alignment 
Range on Protein: 404-452
Range on HMM: 22-70/89.0
LHRPESTKQTIIQSATSPVAVPRSCRRSSADLAKSTSSACGSWQIISGT
|. |.. ..|.     .  .   || .. . .. . .||||||.| ..|
ledPkairktlsCvsvkssgklasCPaglvvtgCaCgsaCGsWdireet
0046846 (Phosphotyrosine protein) phosphatases II 251-335 7.6e-06 21.3 In-house 77-134 (176) alignment 
Range on Protein: 251-335
Range on HMM: 77-134/176.0
FnginlffdwsqdfvdadlsipdrvaTSTGIDWHMYRQWDLvKITQNYLKLLLFLIKDGdSGVLVHCISGWDRTPLFISLLRLSL
.                         .   ..|  .   || .. .. |...   .|.|   |||||  |  ||.... .. | |
i.........................qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllel