Gene MTMR3 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Myotubularin
Subfamily MTMR3
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP033_AA protein Get Run
SpurP033_AA_170-594 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_MTMR3_pd Subfamily MTMR3 141-589 1.7e-230 758.3 In-house 1-441 (442) alignment 
Range on Protein: 141-589
Range on HMM: 1-441/442.0
SFHAWCFDHiqEHREPDGfepgvcFLEGSSKVTHCKFGTEIDRQGFDLKKAWRIFD-NSDFKYCTTYPTQHIVPKEIEDDAMKKSINFRTSKRFPSVVWR
..|||....  |..|.||      ||. ...|...|. .|..|.|||||.||||.| |||||.|..||...||||.|.||..||...||..||.|.||||
ayhawklee..eekerdg......fllraasvaeeklkeeverlGfdlkeawrisdvnsdfklCssyPkklivPksitdddlkkvasfrslkrlPavvwr

HKGNGAVIARCSQPAVGWLGWRSEEDERFMSAILDACAMDDPRKNKKSCHSNGYVksEQYRVTDDQDEM--RRGEYERSNQSKTILIIDARSYAAAFANR
||.||||.||||||.|||||||..|||....|| .|||.|...|.|....|||..  ....|.|..|..  ...|.......|..||.|||||.||||||
hkkngavlarcsqPevgwlgWrnaedekllkaiakacaldagekakgeklsngka..kkkdvsdaldaeadaseeeslaeekkkllivdarsytaafanr

AKGGGCEYPEYYTCCDIEFMGLANIHSVRKSFNTVHALCSnNSLDQTTWLSNLEATKWLQNLSMLLKAAIKVVTAVDQEARPVIVHCSDGWDRTPQIVAL
|||||||..|||..|...|.||||||.||||||...||.| .| |...|||.||.||||||||.|||||.|||.|||.|.|||.||||||||||.|||||
akgGGceleeyypncevvflglanihavrksfnslralls.qspdesnwlsalektkWlqnlsvllkaavkvveavdkegrpvlvhCsdGWdrttqival

AEIMLDPYYRTMQGFQALVEREWLDFGHKFADRCGHRPGQDDANERCPVFLQWLDCIHQLLRQYPTAFEFNETFLVKLVQHTYSCLFGTFLCNSLKARLK
|...|||||||..||..|||||||||||||||||||.. .|||||||||||||||..||| ||.||.|||||.||||||||||||||||||.|| |.| .
akllldpyyrtleGfkvlvereWldfGhkfadrcghgenvddanercPvflqwldavhqlqrqfPtsfefneaflvklvqhtysclfGtflansekeree

NSIKERTCSVWSLIVVEGNKYRNFLYDPKTYKVLYPTCNIRELDLWIAVYLS
...||||.|||||.... ..|||.||..||..||.|....|||.|| .|||.
ekvkertlsvWsllrakekeyrnllykekteavllpavsvrelklwsevyle
0040695 (Phosphotyrosine protein) phosphatases II 178-590 2.3e-138 455.0 In-house 14-385 (388) alignment 
Range on Protein: 178-590
Range on HMM: 14-385/388.0
GTEIDRQGFDLKKAWRIFDNSDFKYCTTYPTQHIVPKEIEDDAMKKSINFRTSKRFPSVVWRHKGNGAVIARCSQPAVGWLGWRSEEDERFMSAILDACA
  |. |.|..|.    .. |.....|..|| . .|||.|.|. .|....||  .|.| ...||. ||||. |.||| ||.|..|| |||....|||... 
lrelkrlglgldlwrisivNenyelcpsYPallvVPksisdellkrvarfrskgriPvlsyrhpnngavllRssqplvglllsrsledeklleailkllp

mddprknkkschsngyvkseqyrvtddqdemrrgeyersnQSKTILIIDARSYAAAFANRAKGGGCEYPEYYTCCDIEFMGLANIHSVRKSFNTVHALCs
                                        .....||.|.|... |.||||.|||.|. ..|..... |... ||| ||.|....  .| 
........................................nlskllivdlrpklnalanralgggvenedaypnaeliflnipnihvvreslqklldac.

NNSLDQTTWLSNLEATKWLQNLSMLLKAAIKVVTAVDQEARPVIVHCSDGWDRTPQIVALAEIMLDPYYRTMQGFQALVEREWLDFGHKFADRCGHRPGQ
 |. | . .|| || ..||. ....|..|. .|  .|..  .|.||||||||||.|...||...|||||||. ||| |.|.||| ||||||||.|| ...
lnvpdslnllslleesgwldliklilelavlivklldlgnssvlvhcsdgwdrtsqlssLaqllldPyYRTleGFqvLiekeWlsfghkfadRlghlese

DDANERCPVFLQWLDCIHQLLRQYPTAFEFNETFLVKLVQHTYSCLFGTFLCNSLKARLKNSIKERTCSVWSLIVVEGNKYRNFLYDPKTYKVLYPTCNI
.| .|..||||..|||..|||||.||||||||..|. |..|.|||.|||||.|| | ||..|. |||.|.||....  ....|.|||| .. ||.| ...
idskefsPvFllFLdcvwqLlrqfPtaFeFnerlLlfLadhlyscrfgtFlfnsekerlelsvsertlslwsyllsrkseflnplYdpsslevllpslsv

RELDLWIAVYLSE
..| ||. .||  
ldlllWleyylrw
Myotub-related Myotubularin-like phosphatase domain 137-537 4.3e-134 439.7 Pfam-A 2-352 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 137-537 4.3e-134 439.7 In-house 2-352 (353) alignment
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 179-589 5.1e-122 399.9 In-house 23-401 (404) alignment 
Range on Protein: 179-589
Range on HMM: 23-401/404.0
TEIDRQGFDLKKAWRIFD-NSDFKYCTTYPTQHIVPKEIEDDAMKKSINFRTSKRFPSVVWRHKGNGAVIARCSQPAVGWLGWRSEEDERFMSAILDACA
 |  |.|.  .  ||| . |||.. | ||| . .||..| |. .||...||. .|.| ..|||. ....|.|.||| ||  . ||||||... .|  |..
eEykRlgikseseWriskinsdyelcetYPkllvvPesisDeelkkvasfRskgRiPvlswrhrsknstitRssqplvGltksrseedEklinsirkakt

MDDprknkkschsngyvkseqyrvtddqdemrrgeyersnqskTILIIDARSYAAAFANRAKGGGCEYPEYYTCCDIEFMGLANIHSVRKSFNTVHALCS
. .                                        |..|.|||..| | ||.||| |.|  . |. |.|||....|||..|.|.. .. ...
qle........................................tlyildarpkanavansakgagyedisryenceieflnienihelreslkklkkavn

NNSLDQTTWLSNLEATKWLQNLSMLLKAAIKVVTAVDQEARPVIVHCSDGWDRTPQIVALAEIMLDPYYRTMQGFQALVEREWLDFGHKFADRCGHRPGQ
..  ... |||.|| ..||.... ||... ..|. ...|  .|.||||||||||.|...|....|||||||..||. |.|.|||.||||||.|.|.. ..
siiekeknwlselessrWldhiklllegskriveliekekssvlvhcsdgwDrtsqlsslsqllldpyyrtiegFivliekewlsfGhkfaqRigqttek

dDANERCPVFLQWLDCIHQLLRQYPTAFEFNETFLVKLVQHTYSCLFGTFLCNSLKARLKNSIKERTCSVWSLIVVEGNKYRNFLY---DPKTYKVLYPT
 . .|| |.|||..||..||..|.|| ||||| ||.|.... ||| |||||..| | | .| ... | |.|.|.  . ..| | ||   . ....    .
.ssdersPiflqFidcvyqltkqfptsFeFnekflikildalyscrfgtFLydsekeRqqnnlaketvslWalleankseylnplyilekkeqkenitss

C-----NIRELDLWIAVYLS
.     .|... ||   || 
essssadikliklWseyylr
subfamily_MTMR1_pd Subfamily MTMR1 302-589 7.8e-111 363.1 In-house 99-385 (389) alignment 
Range on Protein: 302-589
Range on HMM: 99-385/389.0
TDDQDEMRRgEYERSNQSKTILIIDARSYAAAFANRAKGGGCEYPEYYTCCDIEFMGLANIHSVRKSFNTVHALCSNNsLDQTTWLSNLEATKWLQNLSM
..|.  ..    |  .||. .||.|||| ..|.||.|||.| |  |.|. ... |. ..|||.||.|.. ...|.  | .|.. |||.||.||||.....
kedekylqa.ileanaqsekllildarssvnavankakgkgyeseeaYknaelifldihnihvvReslkklkelvlpn.vddkkwlsalestkWlehikl

LLKAAIKVVTAVDQEARPVIVHCSDGWDRTPQIVALAEIMLDPYYRTMQGFQALVEREWLDFGHKFADRCGHRPGQDDANERCPVFLQWLDCIHQLLRQY
.|..|.|.|..|..|.  |.|||||||||| |...|| ..||.||||..||. |.|.||| |||||..| ||   .   .|| |||||..||..|| ||.
ilagavkivekvetektsvlvhcsdGWDRtaqltsLamlllDsyyRtieGfevliekeWlsfGHkfkeRlghgdknssdaersPvFlqfiDcvwqltrqf

PTAFEFNETFLVKLVQHTYSCLFGTFLCNSLKARLKNSIKERTCSVWSLIVVEGNKYRNFLYDPK-TYKVLYPTCNIRELDLWIAVYLS
||||||||.||. |..| |||||||||.|| |.| |...||.| |.|| .  . ....| ||... . |||||.. .|.|.||   || 
ptAFefneefLitlldhlysclfGtflfnsekervkekvkektvslwsyvnsskeeftnplyaeelekkvlypkaslrrlelWkeyylr
subfamily_MTMR6_pd Subfamily MTMR6 284-588 8.8e-93 303.7 In-house 91-393 (397) alignment 
Range on Protein: 284-588
Range on HMM: 91-393/397.0
NKKSCHSNGYVKSEQYRVTDDQDEMRRgEYERSNQSKTILIIDARSYAAAFANRAKGGGCEYPEYYTCCDIEFMGLANIHSVRKSFNTVHALCSNNSLDQ
... | .   .   . | ..|.  ..    .  ..|... ..|.|    |.||.|.| | |  . |. . ..|.|. ||| .|.| . .   . ..| ..
eaaicrcsqplsgfsarcledekllea.irkanpnsellyvvdtrpklnalankaagkGyenednysnikfqfvgienihvmreslqkllevvelksksv

TTWLSNLEATKWLQNLSMLLKAAIKVVTAVDQEARPVIVHCSDGWDRTPQIVALAEIMLDPYYRTMQGFQALVEREWLDFGHKFADRCGHRpgQDDANER
. .|| ||...||. .  .|.|.| .  || .|   |.|||||||||| |...||...|||||||..||. |.|.||| ||||| .|||.   ..|. | 
seflsglessgwlkhikavldasifiakavaeegasvlvhcsdGwdrtaqvcslasllldpyyrtikGflvliekewlsfGhkfsercGll..dedskev

CPVFLQWLDCIHQLLRQYPTAFEFNETFLVKLVQHTYSCLFGTFLCNSLKARLKNSIKERTCSVWSLIVVEGNKYRNFLYDPKTY-KVLYPTCNIRELDL
 |.|.|.|.|. |||.|.|.||||||.||..| .| ||| |||||.|. |.| .. .|||| |.|. .. . ..| | ||...|  .|| |  .  .|.|
sPiftqflecvwqlleqfpkafefnerfllelhdhvyscqfGtflgncekdrrdlklkertkslwayllerkddylnplykaetekevlkpdtapaalkl

WIAVYL
| |.| 
wralyn
subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 279-588 8.9e-75 243.9 In-house 90-402 (405) alignment 
Range on Protein: 279-588
Range on HMM: 90-402/405.0
DDPRKNKK-SCHSNGYVKSEQYRVTDdqDEMRRGEYERSNQSKTILIIDARSYAAAFANRAKGGGCEYPEYYTCCDIEFMGLANIHSVRKSFNTVH-ALC
 ||  |   |  |.  |  |. |. .  ||.   .   |  |||. .||||    |.|| |.| | |    |  | . || . ||| .|||.. .  |. 
kdpssnasisrcsqplvgierarcpe..delycsslalsapsktlylidarpklnaiantangagfenihnypncklvfmnipnihvirksleklvlamk

S-NNSLDQT-----TWLSNLEATKWLQNLSMLLKAAIKVVTAVdQEARPVIVHCSDGWDRTPQIVALAEIMLDPYYRTMQGFQALVEREWLDFGHKFADR
|     |.|      .   .| | |.  .  .|.||      .      ..||||||||||||| .|..|.|||||||..||| |.|.||| |||||. |
ssardkdhtestdmrfwgyieetgwishiksileaatfsaeli.lkgnsilvhcsdgwdrtpqitsltqilldpyyrtivgfqvliekewlsfghkfslr

CGHRPGQDdaNERCPVFLQWLDCIHQLLRQYPTAFEFNETFLVKLVQHTYSCLFGTFLCNSLKARLKNSIKERTCSVWSLIVVEGNKYRNFLYDPKTYKV
 || ||..  .|| |.| |.|||  ||| |.|  |||  ..|. . .  .|| .|||| |  | |... .| .| |.|| . .. ||. |  |.|.  . 
lghlpgne..eerspifqqfldccfqllsqfpllfeftpslllfisdnihsckygtflnncekdrvqdqvktktisiwsevnlnvnkflnpyynpqdiqs

LYPTCNIRELDLWIAVYL
. |    | |.|| |.|.
ikpklysrclelwkacym
subfamily_MTMR9_pd Subfamily MTMR9 320-589 1e-73 240.7 In-house 120-391 (393) alignment 
Range on Protein: 320-589
Range on HMM: 120-391/393.0
KTILIIDARSYAAAFANRAKGGGCEYPEYYTCCDIEFMGLANIHSVRKSFNTVHALCSNNSLDQTTWLSNLEATKWLQNLSMLLKAAIKVVTAVDQEARP
|  ||.| ||  || ..|.|||| |  . |.    .   |....|. .|.  .   ||...|..  .||.||...||...  ||.|| .|....|.|  |
kkGlivdtrsksaaenarskgggietevkysqwkkasrslesvasiqdslaklleacsdaglstdkflsrleksgwlsqvadlleaalvvaqcldeegap

VIVHCSDGWDRTPQIVALAEIMLDPYYRTMQGFQALVEREWLDFGHKFADRCGHRPGQD-DANERCPVFLQWLDCIHQLLRQYPTAFEFNETFLVKLVQH
|.|| ..| | | |...|| ..|||..||..||.||.||||.  || || |. .   ..  .... |||| .|||..|.|.|.| .|||||..|. | .|
vvvhgeeGlDatlqvtsLaqlildpdaRtvrgfealiereWiqaGHPFasRaskvaaketkkklsgpvfllFLDcvyqilsqfpasFEFneelLillfeh

TYSCLFGTFLCNSLKARLKNSIKERTCSVWSLIVVEG--NKYRNFLYDPkTYKVLYPTCNIRELDLWIAVYLS
.||. ||||||.. . | .. .|..| |.|| .  .   ... | ||.. . .|. |  .   | ||  .|| 
syssqfgtflcdneaerkelklkkktvslwsyvnrpeklkqflnplyea.naeviwpsvapqslelWselylr
subfamily_MTMR5_pd Subfamily MTMR5 190-584 1.7e-73 240.1 In-house 29-476 (483) alignment 
Range on Protein: 190-584
Range on HMM: 29-476/483.0
KAWRIFD-NSDFKYCTTYPTQHIVPKEIEDDAMKKSINFRTSKRFPSVVWRHKGNGAVIARCSQP----AVGWLG---------------WRSEEDERFM
. .||   |.... | .||   .||.|..||....  .    .|.| |.|||. |.|.. | ...     || |                 .| | |...
gkfrisevNkkytvcrsYPalivvPsevsddsiarvakcfrqnRlPvvtWrhernkalLiRsggfeskgvvgllksantqgsstsessessksleqekyl

SAILDACAMDDPRKNKKS------CHSNGYVKSEQYRVTDDQDEMRRGEYERSNQSKTILIIDA---RS-------YAA--AFANRAKGGGCEYpEYYTC
.|.. . ..  . . ..|       . .  ..... ...  ..... .. ....| ..   .     ..        ||  .. ....  . .  | ...
kavvnevsklsalalnsslevslsvlasssssdkraalsteknaldisksdkasqggkgatlkennakeskklrarkaaLYvlgeksqlknvks.evdsk

CDIEFMGLANIHSVRKSFNTVHALCSNNSL----DQTTWLSNLEATKWLQNLSMLLKAAIKVVTAVDQEARPVIVHCSDGWDRTPQIVALAEIMLDPYYR
...  . | .|  |..||. .   |. .      .....|. .|.  ||| .| ||. .  ||  .| .   |.|   |||| | |...||...||||||
aefipvelveirqvkasfkkllraClpstaveeaesqsFlksvedseWlqqissllqlsgavvdlldlqgssvlvslEdGwdvtaqvsslaqllldpyYR

TMQGFQALVEREWLDFGHKFADRCGHRPGQDDAnERCPVFLQWLDCIHQLLRQYPTAFEFNETFLVKLVQHTYSCLFGTFLCNSLKARLKNSI-------
|..||..|||.||| |||.|..|. . . .  .    |||||.|||.||. ||.|.|||||. .|  |  |  |. | ||| .| . ||....       
tleGFkvLveKEWLafGHrFtkrsnqtlsaqss.gfaPvFlqFLDcvhqvsrqfPlafefndfylkflayhsvsnrfrtfllDseyerlesgllyeekae

---KERTCSVWSLIVVEGNK---YRNFLYDPKTYKVLYPTCNIRELDLWI
   |. . |||  |  . ..   . ||||.|.  .|| |..|. .|..| 
krakkagksvwdyidrqhkrspifynflyspdesevlrPssnvsslkvWd
subfamily_MTMR10_pd Subfamily MTMR10 359-543 7.8e-55 178.2 In-house 123-310 (380) alignment 
Range on Protein: 359-543
Range on HMM: 123-310/380.0
LANIHSVRKSFNTVHALCSNNSLD-----QTTWLSNLEATKWLQNLSMLLKAAIKVVTAVDQEARPVIVHCSDGWDRTPQIVALAEIMLDPYYRTMQGFQ
|..|. | |... ...|| ...       .  |||.|| |.||.  ...|. |...| .| .. |.||.  |.| |    .  || .||||.|||..|||
lpsiqdvqkaylklreLcvidtseefvtlddkwlssLektrWLayvrlclstasdavktvvekkrsvilqesegrDlscvvaSLaqlmldphyrtisGfq

ALVEREWLDFGHKFADRCGHRPGQDDANErcPVFLQWLDCIHQLLRQYPTAFEFNETFLVKLVQHTYSCLFGTFLCNSLKARLKNSIKER
 |...||   ||.| ||.||   ......  ||||  ||| .|||.|.|..|||.||||..|. ...|..|.|||.|| ..|||.. .  
sliqkewvaaghpfldrlghikpsekses..pvfllFldcvdqlleqfpseFeFtetfLialwdsshsgifltflfnseeqrlkavvsss
subfamily_pats1_pd Subfamily pats1 351-481 2.5e-26 84.2 In-house 335-467 (691) alignment 
Range on Protein: 351-481
Range on HMM: 335-467/691.0
CCDIEFMGLANIHSVRKSFNTVHA--LCSNNSLDqtTWlSNLEATKWLQNLSMLLKAAIKVVTAVDQEARPVIVHCSDGWDRTPQI---VALAEIMLDPY
 ..|.|. |   . |.. |. .    |  ..| |   | ...|  ||. .. .||.||.|| . .|.    ..   .|. . . ..    .|| ...||.
ssniiflslPtrekveerffdllqsilsldgsdd..ew.keieeskwvdsvkllleaavkvsnlldeGssvllknsidsPlieldlasisslaqvlsdPf

YRTMQGFQALVEREWLDFGHKFADRCGHRPGQDDAN
|||. ||. |.|.|||..|. |.... |.  .|  |
yrtldGfkvliekewlsyGfPfskinyhkesddlnn
subfamily_MTMR1_pd Subfamily MTMR1 178-277 1.9e-24 78.7 In-house 13-113 (389) alignment 
Range on Protein: 178-277
Range on HMM: 13-113/389.0
GTEIDRQGFDLKKAWRIFD-NSDFKYCTTYPTQHIVPKEIEDDAMKKSINFRTSKRFPSVVWRHKGNGAVIARCSQPAVGWLGWRSEEDERFMSAILDAC
 .|..|.|   .|.||| . |.... | |||.  .||| ..|. .||. .||  .|.|...| .| |.|||.|.||| ||  | ||.|||....|||.| 
eaelerlgllneklWritklnkkyelcdtYpavlvvpkvvsdedlkkvaafrskgRlPvlswlnkenqavilrasqplvGlsgkrskedekylqailean

A
|
a
FYVE FYVE zinc finger 1090-1152 8.3e-23 70.1 Pfam-A 3-67 (69) alignment 
Range on Protein: 1090-1152
Range on HMM: 3-67/69.0
WIPDHAVSHCSLCNSRFNLVVRKHHCRNCGQIFCATCSNFFIAIP--REQLYQPQRVCQPCHQRL
| .|.....|. |...|.|. |.||||.||...|..||. ... .  ...  ...|||. |...|
wvddaeakkCeiCakkFsltrrrhhCrlCGkvvCskCsskrvekleeesaeekevrvCkeCleel
subfamily_MTMR9_pd Subfamily MTMR9 189-276 3.4e-22 71.1 In-house 31-119 (393) alignment 
Range on Protein: 189-276
Range on HMM: 31-119/393.0
KKAWRIF-DNSDFKYCTTYPTQHIVPKEIEDDAMKKSINFRTSKRFPSVVWRHKGNGAVIARCSQPAVGWLGWRSEEDERFMSAILDAC
...|||   | .|| |..||.. |||| |.|...|.| .||   |||   ..|| ..||. |.||| .|  | | .|||... ..| . 
sdewRissvNknfkvcasypesvivPkaiddeelkasaafreggrfPvLsylhketkavllrssqplcgssgkrckedekllnlvlkkl
subfamily_pats1_pd Subfamily pats1 484-565 2.2e-21 67.9 In-house 553-634 (691) alignment 
Range on Protein: 484-565
Range on HMM: 553-634/691.0
CPVFLQWLDCIHQLLRQYPTAFEFNETFLVKLVQHTYSCLFGTFLCNSLKARLKNSIKERTCSVWSLIVVEGNKYRNFLYDP
 |.|.|.|| . || ...|. ||||| .|. ||....|  ||.||..  | .  . . .|. |.||.|  .  .. |.|| .
sPifvqfldlvwqlqkefPfhfefneslllllvkesfssrfGnflyseakrdserkvlkrsksiwsfinqnksrfinllykh
subfamily_MTMR6_pd Subfamily MTMR6 178-277 1.2e-16 53.0 In-house 25-123 (397) alignment 
Range on Protein: 178-277
Range on HMM: 25-123/397.0
GTEIDRQGFDlKKAWRIFD-NSDFKYCTTYPTQHIVPKEIEDDAMKKSINFRTSKRFPSVVWRHKGNGAVIARCSQPAVGWLGwRSEEDERFMSAILDAC
 .|. |.|   ...| . | | |.. | |||..  |||... . .  |  ||. .|.| . . || | | | |||||  |    |..|||... || .| 
kaeytrmgvp.nekwtltdlnkdyelcdtyprelyvPksatkevlvgsskfrskgrlPvlsylhkeneaaicrcsqplsgfsa.rcledeklleairkan

A
.
p
subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 177-272 9.9e-14 42.9 In-house 28-123 (405) alignment 
Range on Protein: 177-272
Range on HMM: 28-123/405.0
FGTEIDRQGfDLKKAWRIFD-NSDFKYCTTYPTQHIVPKEIEDDAMKKSINFRTSKRFPSVVWRHKGNGAVIARCSQPAVGWLGWRSEEDERFMSAI
|  .|| .  . .  |.. . | ..| |..|..  .| .   |  ..| . ||.  | ||. |.     | |.||||| ||    |  ||| . |..
fniyideen.ssncywkvtsinkeykmcssyssslvvlskaldkdlekifsfrskgripslswkdpssnasisrcsqplvgierarcpedelycssl
PTPc_DSPc_SM00012 407-514 1.7e-10 36.4 In-house 23-99 (105) alignment 
Range on Protein: 407-514
Range on HMM: 23-99/105.0
IKVVTAVD-------QeARPVIVHCSDGWDRTPQIVALAEIMLDPYYRTmqgfqalverewldfghkfadrcghrpgqddanercpVFLQWLDCIHQLLR
.... ||.       . . ||.||||.|..|| ..|||. .. . ...|                                      ..........| .
lellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqleket.....................................kevdifqivkelrk

QYPTAFEFNETFLVK
| |......| .|. 
qRpgmvqteeqylfl
subfamily_pats1_pd Subfamily pats1 180-249 2.6e-09 28.0 In-house 14-82 (691) alignment 
Range on Protein: 180-249
Range on HMM: 14-82/691.0
EIDRQGFDLKKAWRIFDNSDFKYCTTYPTQHIVPKEIEDDAMKKSINfRTSKRFPSVVWRHKGNGAVIAR
| .| . || | ||. .  . . .. || . .||| . |. .. ..  ..| ..| . | .. | ... |
egqrlkldldkdwrvveflsrdlseiyPkrilvPklvsdellvsyvr.krsskiPvlswsnqnnksslfr
0051429 (Phosphotyrosine protein) phosphatases II 393-452 5.9e-08 28.2 In-house 128-177 (272) alignment 
Range on Protein: 393-452
Range on HMM: 128-177/272.0
TKWLQNLSMLlKAAIKVVTAVDQeARPVIVHCSDGWDRTPQIVALAEIMLDpyyrtmqgF
| |.       .| .... .. .  .||.|||| |.|||  .|||  ..|.        .
tdwpdhgvpq.eallellellld.ggpvlvHCsaGkdRTGtvvallllllg........v
subfamily_MTMR14_pd Subfamily MTMR14 402-473 1.8e-07 22.3 In-house 255-330 (357) alignment 
Range on Protein: 402-473
Range on HMM: 255-330/357.0
LLKAAIKVVtaVDQEARPVIVHCSDGWDRTPQIVALAEIMLDPYYRTMQGFQA------LVEREWLDFGHKFADRCGH
 ||. .| |   ..|   ..|||  ||||||  |.|  . |    .  | ..|       |  .|. |||...||  .
ylklllkyv..kededsGllvhcisGWdrtPlfvsllrlslWadglihqslsaaellyltvaydWflfghqlpdrlkk
0045098 (Phosphotyrosine protein) phosphatases II 397-466 2.5e-07 25.9 In-house 172-266 (278) alignment 
Range on Protein: 397-466
Range on HMM: 172-266/278.0
QNLSMLLKAAIKVVTAVDQ--------------EARPVIVHCSDGWDRTPQIVAlAEIMLDP------------YYRTMQGFQALVEREWLDFGHK
..... .  ... . .. .              .  ||.|||| |..||  .|| | .||.             ..|.. ...|.   |.. | ..
lpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlva.aylmlelleggvdlleavkelrsqRpglavqnleqyrflye
0051082 (Phosphotyrosine protein) phosphatases II 383-442 5.4e-07 24.9 In-house 72-117 (151) alignment 
Range on Protein: 383-442
Range on HMM: 72-117/151.0
QttwlsnleatkwlqnLSMLLKAAIKVVTAVDQE-ARPVIVHCSDGWDRTPQIVALAEIML
.               |.....|..... ....    ||.|||| |..||  .|||  ..|
g...............lplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmll
0049772 (Phosphotyrosine protein) phosphatases II 402-442 9.1e-07 24.4 In-house 198-237 (314) alignment 
Range on Protein: 402-442
Range on HMM: 198-237/314.0
LLKAAIKVVTAVdQEARPVIVHCSDGWDRTPQIVALAEIML
 ........ .. .. .||.|||..|..||.  |..| .|.
dfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmk
0044763 (Phosphotyrosine protein) phosphatases II 398-438 1.1e-06 23.9 In-house 90-131 (178) alignment 
Range on Protein: 398-438
Range on HMM: 90-131/178.0
NLSMLLKAAIKVVTAVD-QEARPVIVHCSDGWDRTPQIVALA
.|.  . .... . ..  .. .||.|||| |..|.. .||. 
dllehflefvefieealdekggpvlVHCsaGvgRsgtlvaay
0043336 (Phosphotyrosine protein) phosphatases II 389-440 1.2e-06 23.7 In-house 182-233 (278) alignment 
Range on Protein: 389-440
Range on HMM: 182-233/278.0
NLEATKWLQNLSMLLKAAIKVVTAVDQEARPVIVHCSDGWDRTPQIVALAEI
.    ..  .||.||.   .| .|.. .  ||.||||.| .||  ..||  .
gwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyll
0048076 (Phosphotyrosine protein) phosphatases II 397-439 1.6e-06 23.4 In-house 61-103 (145) alignment 
Range on Protein: 397-439
Range on HMM: 61-103/145.0
QNLSMLLKAAIKVVTAVDQEARPVIVHCSDGWDRTPQIVALAE
..|. || .... . .. .| .||.|||| | .||. .||.  
pdllellleflefieealkeggpvlVHCsaGvgRtgtlvaayl
0039614 (Phosphotyrosine protein) phosphatases II 394-440 1.8e-06 23.1 In-house 192-245 (297) alignment 
Range on Protein: 394-440
Range on HMM: 192-245/297.0
KWLQNLSM-LLKAAIKVVTAVDQ------EARPVIVHCSDGWDRTPQIVALAEI
.|  .    .|.  .... .|..      . .||.||||.| .||  ..|.  .
gwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylm
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 404-441 2.1e-06 22.0 In-house 196-233 (307) alignment 
Range on Protein: 404-441
Range on HMM: 196-233/307.0
KAAIKVVTAVDQEARPVIVHCSDGWDRTPQIVALAEIM
 .|| .. ||  .  ||.|||| |  |.  |||.. ..
ltainlleavrydtnpvvvhcsaGvGrsGtivaislvq
0049260 (Phosphotyrosine protein) phosphatases II 397-448 2.6e-06 22.7 In-house 68-115 (152) alignment 
Range on Protein: 397-448
Range on HMM: 68-115/152.0
QNLSMLLKAAIKVVTA-VDQEARPVIVHCSDGWDRTPQIVALAEIMldpyyRT
..||.||. .....     ..  ||.|||| | .||. .||.  ..     . 
pdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.....lg
0048179 (Phosphotyrosine protein) phosphatases II 397-440 2.6e-06 22.8 In-house 63-106 (144) alignment 
Range on Protein: 397-440
Range on HMM: 63-106/144.0
QNLSMLLKAAIKVVTAVDQEARPVIVHCSDGWDRTPQIVALAEI
 .|. || .... . .. .| .||.|||| | .||. .||.  .
pdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylm
0040439 (Phosphotyrosine protein) phosphatases II 402-440 4.8e-06 21.8 In-house 158-202 (249) alignment 
Range on Protein: 402-440
Range on HMM: 158-202/249.0
LLKAAIKVVTAVDQ------EARPVIVHCSDGWDRTPQIVALAEI
 .. ... . ||..      .  ||.||||.| .||. ..|.  .
sfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylm
0043147 (Phosphotyrosine protein) phosphatases II 403-447 4.8e-06 21.9 In-house 84-125 (172) alignment 
Range on Protein: 403-447
Range on HMM: 84-125/172.0
LKAAIKVVTA--VDQEARPVIVHCSDGWDRTPQIVALAEIMldpyyR
|  ... .    . ..  ||.|||| |..||. .||.  ..     .
lleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.....l
subfamily_MTMR10_pd Subfamily MTMR10 195-252 6.4e-06 17.2 In-house 30-86 (380) alignment 
Range on Protein: 195-252
Range on HMM: 30-86/380.0
FDNSDFKYCTTYPTQHIVPKEIEDDAMKKSINFRTSKRFPSVVWRHkGNGAVIARCSQ
  |  |. ..|.|.. .||. ..|. ... ..  .  |||  || | ..||.  |.|.
lknelfaaaqtlPqyfvvpnslsdsdverlsrhykesRfplwvwsh.akgaallrlsa
0051299 (Phosphotyrosine protein) phosphatases II 395-440 6.8e-06 21.2 In-house 197-242 (288) alignment 
Range on Protein: 395-440
Range on HMM: 197-242/288.0
WLQNLSMLLKAAIKVVTAVDQEARPVIVHCSDGWDRTPQIVALAEI
. .....||.   .| .|  .   ||.||||.| .||  ..||  .
vpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdll
0036282 (Phosphotyrosine protein) phosphatases II 399-443 7e-06 21.4 In-house 85-130 (174) alignment 
Range on Protein: 399-443
Range on HMM: 85-130/174.0
LSMlLKAAIKVVTAVDQE--ARPVIVHCSDGWDRTPQIVALAEIMLD
||. |  ..| |  . .|   .||.|||| | .||. .||.  ..  
lsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrg