Gene MTMR5-1 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Myotubularin
Subfamily MTMR5
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP034_AA protein Get Run
SpurP034_AA_693-848 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
SBF2 Myotubularin protein 75-315 8.8e-83 266.3 Pfam-A 9-225 (225) alignment 
Range on Protein: 75-315
Range on HMM: 9-225/225.0
NFEGHRNLVNNSARRLEVLRTCINFIFENKILDARRLFPAVMRSLKSRVARQALLHELELHVNKNRAMLEPQQFSMVVRLINAALQEDSHSEEFSLSMDF
 .| ... |.||||||||||.||..||.||||.|....|||.|.|||. ||.|| .|||.||..|||.|. ||| .||||.|.|||.||...| ..   .
ivektkstvensarrlEvlrnCisyiFdnkileakKslpAvlralkskaaRlalceelekhvqqnravLdhqqFDlvvrlmNkaLqddsakdeygvaaal

LPLISAFCRKLCPGIIQFAYTVTQDHPVFASHAFWETAFYADVEKNIQSLYVTpdntptyekkdvsqsfndafaagpDASGSSASSAAANGLITSAERSP
||| |||||||..|..|||||. |||||.... |||..|| .|.|.|..|| .                        . | |. ..  .. |....|.| 
lplssafcRKLsegvsqfaYtcvqdHpvWknqqFWeatfyqevqkaikelyle........................kkseskkkkktesslskkeeksa

LDIAAEQLRLQPNMNHDAREEAKSNEESIVYSQAVHYANRM
|.|||.|||..|..... ..|  ..||| |||||.|.|||.
leiaadqlrkwptlskekqkelvkkeestvysqaihfanrl
subfamily_MTMR5_pd Subfamily MTMR5 692-892 5.2e-68 222.0 In-house 2-184 (483) alignment 
Range on Protein: 692-892
Range on HMM: 2-184/483.0
VEKLAERQYVQDYTRLGLGLLgNGAisrPRVGDmFKISEVNSKFEVSRSYPALIVVPSVLSDDSIRRLAKCHRHGRLPAITWRHQRTKGLLIRSSGFHGK
|||||||.|||||.|||||.| |||   ...|. |.|||||.|..|.||||||||||| .|||||.|.|||.|..|||..||||.|.|.|||||.||..|
veklaerayvqdykRlGlgal.nga...skrgk.frisevNkkytvcrsYPalivvPsevsddsiarvakcfrqnRlPvvtWrhernkalLiRsggfesk

GVMGMIKSAQTQGSSTSESSGSSKSLEQEKYLSAIVLNTPYGSAHKSDslVSLNSILPPTNSGETPDGTPTISPRkgthgtgtllqRGFLRSSGGQKAYT
||.|..|||.||||||||||.|||||||||||.|.| .... ||....  .||...|. ..| ...| ....|..           ...|..| ..||..
gvvgllksantqgsstsessessksleqekylkavvnevsklsalaln..sslevslsvlasssssdkraalste...........knaldisksdkasq

G
|
g
0040695 (Phosphotyrosine protein) phosphatases II 691-831 8.6e-24 78.0 In-house 4-113 (388) alignment 
Range on Protein: 691-831
Range on HMM: 4-113/388.0
TVEKLAERQYVQDYTRLGLGLlgngaisrprvgDMFKISEVNSKFEVSRSYPALIVVPSVLSDDSIRRLAKCHRHGRLPAITWRHQRTKGLLIRSSGFHG
..|   .. ......||||||            |...|| ||...|...|||||.|||. .||. ..| |.. ..||.|....||.... .|.||| ...
leegwslydilrelkrlglgl............dlwrisivNenyelcpsYPallvVPksisdellkrvarfrskgriPvlsyrhpnngavllRssqplv

kgvmgmiksaqtqgsstseSSGSSKSLEQEKYLSAIVLNTP
                   .   |.|||.||.|.||.  .|
...................glllsrsledeklleailkllp
Myotub-related Myotubularin-like phosphatase domain 692-826 1.8e-23 75.8 Pfam-A 18-122 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 692-826 1.8e-23 75.8 In-house 18-122 (353) alignment
subfamily_MTMR3_pd Subfamily MTMR3 722-786 4.8e-17 54.9 In-house 40-104 (442) alignment 
Range on Protein: 722-786
Range on HMM: 40-104/442.0
VGDMFKISEVNSKFEVSRSYPALIVVPSVLSDDSIRRLAKCHRHGRLPAITWRHQRTKGLLIRSS
. ....||.|||.|.. .|||  ..||....||.... |.    .||||. |||.... .|.|.|
lkeawrisdvnsdfklCssyPkklivPksitdddlkkvasfrslkrlPavvwrhkkngavlarcs
subfamily_MTMR9_pd Subfamily MTMR9 722-786 1.9e-15 48.9 In-house 30-94 (393) alignment 
Range on Protein: 722-786
Range on HMM: 30-94/393.0
VGDMFKISEVNSKFEVSRSYPALIVVPSVLSDDSIRRLAKCHRHGRLPAITWRHQRTKGLLIRSS
. | ..||.|| .|.|  |||. ..||  ..|....  |.  ..||.| ....|..||  |.|||
asdewRissvNknfkvcasypesvivPkaiddeelkasaafreggrfPvLsylhketkavllrss
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 725-787 2.5e-15 48.6 In-house 35-97 (404) alignment 
Range on Protein: 725-787
Range on HMM: 35-97/404.0
MFKISEVNSKFEVSRSYPALIVVPSVLSDDSIRRLAKCHRHGRLPAITWRHQRTKGLLIRSSG
 ..||..||..|.. .|| |.|||. .||. . . |.   .||.|...|||. ..  ..||| 
eWriskinsdyelcetYPkllvvPesisDeelkkvasfRskgRiPvlswrhrsknstitRssq
subfamily_MTMR1_pd Subfamily MTMR1 725-789 2e-14 45.7 In-house 26-90 (389) alignment 
Range on Protein: 725-789
Range on HMM: 26-90/389.0
MFKISEVNSKFEVSRSYPALIVVPSVLSDDSIRRLAKCHRHGRLPAITWRHQRTKGLLIRSSGFH
...|...|.|.|.. .|||..|||.| ||. ... |. . .|||| ..| .....  ..|.|   
lWritklnkkyelcdtYpavlvvpkvvsdedlkkvaafrskgRlPvlswlnkenqavilrasqpl
GRAM GRAM domain 432-513 1.6e-11 35.0 Pfam-A 5-68 (69) alignment 
Range on Protein: 432-513
Range on HMM: 5-68/69.0
KPTFLPGEEKVMEGLRGYLVLDgreegqggvmggptLLPAEGAVFLTTYRIIFKGTPIDMQAceqvVTRSFPVSALVKEKKI
|.  ||.|||. . .. ||  .              ..|..|...||.||.||.. . | ..    |....|.... . .|.
ktfklppeEkllddyaCylsts..............kgpvqGrlYlTnyrliFrSdklddsk....vvvvipladikrveks
subfamily_MTMR10_pd Subfamily MTMR10 721-786 7.7e-09 26.8 In-house 21-86 (380) alignment 
Range on Protein: 721-786
Range on HMM: 21-86/380.0
RVGDMFKISEVNSKFEVSRSYPALIVVPSVLSDDSIRRLAKCHRHGRLPAITWRHQRTKGLLIRSS
 | | .. . .| .|..  ..|  .|||  |||. ..|| . .. .| |  .| | ... ||. | 
tvsdaivvllknelfaaaqtlPqyfvvpnslsdsdverlsrhykesRfplwvwshakgaallrlsa
subfamily_MTMR6_pd Subfamily MTMR6 725-786 1.8e-06 19.5 In-house 37-98 (397) alignment 
Range on Protein: 725-786
Range on HMM: 37-98/397.0
MFKISEVNSKFEVSRSYPALIVVPSVLSDDSIRRLAKCHRHGRLPAITWRHQRTKGLLIRSS
 ......| ..|.  .||  ..||.  . . .   .|   .|||| ... |....  . |.|
kwtltdlnkdyelcdtyprelyvPksatkevlvgsskfrskgrlPvlsylhkeneaaicrcs