Gene OCA in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family OCA
Subfamily OCA
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP039_AA protein Get Run
SpurP039_AA_20-330 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0051429 (Phosphotyrosine protein) phosphatases II 21-330 1.5e-36 121.8 In-house 1-269 (272) alignment 
Range on Protein: 21-330
Range on HMM: 1-269/272.0
LPIETLPNLRRVDSRGR------LYRSSRQDLLSRADTERLNDLGIRSVLDFRSKSEYKAASGDKIFDqnssileviipkgqssakgicdvstkpvkmky
||.... | | |.  ||      ||||..   |. || .|| .|||....|.|| .|...   |.                                   
lplsgyiNardvggygrvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywp................................

lkaiknkeaptldgcnsthhsaitrkrflldffkfHFVWTVFNRIPLYKRLFSLVYLIVDILFRTHFRYFIRYF--------AKETlnPAGLLSTYIDMI
                                   .. . ... .. .    .. .| | .|. ... ..| ..        |.|.  .  .. .|.|..
...................................girylhlpilddsaptilygalrvtllseellldyilrellltlllsagea..revmhlhytdwp

ELSGAQ--ICLALRILSDpaNLPAMVNCAHGKDRTGIVIAMVLSLLGKSDDYIAEEYALSEIGLDPIRSRVHQEIVER--------------TNMDESFT
  . .|  .. .|..| |  . | .| |..||||||.|.|..|.||| |.. |...|.|....|....... .                    .. .|..
dhgvpqeallellellld..ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrsll

HAKRETMDGLLQYIHKTYSTVPNYLESIGFGREDQEKLLQ
....|...  |..|...| .| .||...|.. |..|.| .
svraeyllaaldaideeyGsvegYLrdlglseeelerLre
subfamily_OCA_pd Subfamily OCA 133-330 4e-23 72.2 In-house 88-274 (282) alignment 
Range on Protein: 133-330
Range on HMM: 88-274/282.0
HHSAITRKRFLLDFFKFHFVWTVFNRIP-LYKRLFSLVYLIVDILFRTHFryFIRYFAKETLNPAGLLSTYIDmielsGAQICLALR-ILSDPANLPAMV
|. .   .|.|.| |   ..  . |..  .  .| ... | .| .| |||  | |     ...  .|...| |      ..|.  || .|....||| ..
hkdtsvgrrylfdvfskelirhignqvniiitilavmfllpidkifgthf..fprlyslvpprnfslveeykd.....kpvisgllrlllpeeenlpfLi

ncahgkDRTGIVIAMVLSLLGKSDDYIAeEY-ALSEIGLDPIRSRVHQEIVERTNMD-ESFTHAKRETMDGLLQYiHKTYSTVPNYLESIGFGREDQEKL
      ||.|.  |..|.  . ... || .. | |||.|  .| .| ...... |.  | . .||..|. ..|.   | |...  |||.|||  ||||.|
......drlglktaliLdaeeveretia.dflasseiklvslrnevlkdlldndnyavelscqaktdtvlkvLrk.dkkygstsiyleyigFtledqesl

LQ
 .
ks
0051082 (Phosphotyrosine protein) phosphatases II 23-265 7.8e-17 56.7 In-house 2-132 (151) alignment 
Range on Protein: 23-265
Range on HMM: 2-132/151.0
IETLPNLRRVDSRgrLYRSSRQdllSRADTERLNDLGIRSVLDFRSKSEYKaaSGDKIFDQNSsileviipkgqssakgicdvstkpvkmkylkaiknke
.....|...|...  ||||.     . .. | | .|||......||. |..     ... ...                                     
lsdyinfsyvtgg..lyrsggp...ladflellkelgiktivnlrseeerg..ycpeylpelg.....................................

aptldgcnsthhsaitrkrflldffkfhfvwtvfnriplY-------------KrlfslvylivdilfrthfryfiryfaketlnpagllstyidmIELS
                                                     .                                          ..||
.......................................ievlhipildwpdpg..........................................lpls

GAQICLALRILSDPANLPAMVNCAHGKDRTGIVIAMVLSLLGKSDDYIAEEYALSE
 ...  .|..| |. | |  | | .||.|||...|..| ||| | . . ||| |. 
fdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllgvsleealeeyrlkr
Y_phosphatase3 Tyrosine phosphatase family 191-265 2.3e-16 55.3 Pfam-A 91-164 (164) alignment 
Range on Protein: 191-265
Range on HMM: 91-164/164.0
ETLNPAGLLSTYIDMIELSGAQICLALRILSDPANlPAMVNCAHGKDRTGIVIAMVLSLLGKSDDYIAEEYALSE
.. . . . ..| ...| . ...  .|..| .... |....|..||||||.|.|..||||| ... ||..|.|..
aeeaeeamaeayreiledekkayrkvlealaeeeg.pvlfHCtaGKDRTGvvaalllsllgvdeetiaaDYlltn
Y_phosphatase3 Tyrosine phosphatase family 35-83 1.2e-09 33.4 Pfam-A 18-65 (164) alignment 
Range on Protein: 35-83
Range on HMM: 18-65/164.0
RGRLYRSSRQDLLSRADTERLNDLGIRSVLDFRSKSEYKAAsGDKIFDQ
.|.||||.. . |. || ..|..|||. |.|.||..| ...  ||. ..
pgvlyRSaalsklteadlaaLaelgiktvvDLRseeEveke.pdklpeg
Y_phosphatase3C Tyrosine phosphatase family C-terminal region 284-328 7.6e-09 25.0 Pfam-A 15-63 (68) alignment 
Range on Protein: 284-328
Range on HMM: 15-63/68.0
NMDE---SFTHAKRETMDGLLQYIHKTYSTVPNYL-ESIGFGREDQEKL
. .|   ..  ...|.... |. | ..| .| .|| | .|. .||.|.|
adrealrpllgvreeyleaaldtideryGsvegYLeeaLGlseedierL
0049772 (Phosphotyrosine protein) phosphatases II 209-264 1.3e-08 30.4 In-house 195-253 (314) alignment 
Range on Protein: 209-264
Range on HMM: 195-253/314.0
SGAQICLALRILSD-PANLPAMVNCAHGKDRTG--IVIAMVLSLLGKSDDYIAEEYALS
. ...  .|... . ... |  | |..||.|||  .|.|....||| | . . |.. | 
lledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlk
0042113 (Phosphotyrosine protein) phosphatases II 205-261 1.7e-07 26.4 In-house 163-218 (245) alignment 
Range on Protein: 205-261
Range on HMM: 163-218/245.0
MielsgaqICLALRILSDPANLPAMVNCAHGKDRTGIVIAMVL------SLLGKSDDYIAEEY
.       . .....|....| | .| | .|..||| .||. |      ..|| | . . .|.
f.......lefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkel
Y_phosphatase2 Tyrosine phosphatase family 206-263 3.2e-07 22.3 Pfam-A 72-129 (165) alignment 
Range on Protein: 206-263
Range on HMM: 72-129/165.0
IELSGAQICLALRILSDPANLPAMVNCAHGKDRTGIVIAMVLSLLGKSDDYIAEEYAL
.|.   ..  ||..| . .| | .. | .|| |||.||...  | . |   | .|| .
veiksdllkkalklllnkenypvllhckrGkhrtglvigclRklqkWslasilnEyrr
0044763 (Phosphotyrosine protein) phosphatases II 27-249 2.9e-06 22.6 In-house 21-134 (178) alignment 
Range on Protein: 27-249
Range on HMM: 21-134/178.0
PNLRRVDSRgrLYRSSRQDllsRADTERLNDLGIRSVLDFRSKSEYKAASGDKIFDQNSSileviipkgqssakgicdvstkpvkmkylkaiknkeaptl
.|. ... .  ||..|  .    .| | | .|||........  |.   . |. . .. .                                        
inaseilpg..lylgslpp...addlellkelgithivnlteelelgflkcdpywpeeag........................................

dgcnsthhsaitrkrflldffkfhfvwtvfnriP--------------LYKRLFSLVYLIVDILfrthfryfiryfaketlnpagllstyidmielsgaq
                                                |.. .. .| .| ..|                                    
.................................iqylhipipDhgvpdllehflefvefieeal....................................

iclalrilsDPANLPAMVNCAHGKDRTGIVIAMVLSL
         |. . |  | | .|..|.| ..|. | .
.........dekggpvlVHCsaGvgRsgtlvaaylmk
subfamily_OCA_pd Subfamily OCA 36-74 4.7e-06 16.2 In-house 24-62 (282) alignment 
Range on Protein: 36-74
Range on HMM: 24-62/282.0
GRLYRSSRQDLLSRADTERLNDLGIRSVLDFRSKSEYKA
| ||||.. | ..  |   . .|||.|..| | . ||. 
gllyrsaktdyvtakdkslflqlgiksiidirgekeyrk
DUF2393 Protein of unknown function (DUF2393) 151-217 7.3e-06 12.0 Pfam-A 3-68 (149) alignment 
Range on Protein: 151-217
Range on HMM: 3-68/149.0
FVWTVFNRIPLYKRLFSLVYLIVDILFRTHFRYFIRYFAKETLNPAGLLSTYIDMIElSGAQICLAL
||  .|  |...|.|. |...|..|.. . . .|.... ......| |  |..  .  .. .|   .
fvlllflsilqkkklvlllliiasiilillvyifgykvldkytkkaeltltsnkrls.ysesiyvdg